Updated on 2021/04/21

写真a

 
TAOKA Toshiaki
 
Organization
Graduate School of Medicine Department of Innovative Biomedical Visualization (iBMV) Industry-Academia Collaborative Chair Designated professor
Title
Designated professor

Degree 1

  1. 博士(医学) ( 1999.2   奈良県立医科大学 ) 

Current Research Project and SDGs 2

  1. 神経領域の拡散画像

  2. Imaging for glymphatic system

Research History 17

  1. Graduate School of Medicine, Nagoya University   Department of Innovative Biomedical Visualization (iBMV)   Professor

    2019.10

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    Country:Japan

  2. Nagoya University   Graduate School of Medicine Industry-Academia Cooperative Research Course   Designated professor

    2019.10

  3. Nagoya University Hospital   Department of Radiology   Associate professor of hospital

    2015.4 - 2019.9

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    Country:Japan

  4. Nagoya University Hospital   Department of Radiology   Associate professor of hospital

    2015.4 - 2019.9

  5. 奈良県立医科大学准教授(中央放射線部)

    2007.10 - 2015.3

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    Country:Japan

  6. Nara Medical University

    2007.10 - 2015.3

  7. 奈良県立医科大学講師(中央放射線部)

    2006.7 - 2007.9

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    Country:Japan

  8. 奈良県立医科大学学内講師(中央放射線部)

    2005.1 - 2006.6

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    Country:Japan

  9. 奈良県立医科大学助手(中央放射線部)

    2004.4 - 2004.12

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    Country:Japan

  10. 奈良県立医科大学助手(放射線医学)

    2002.6 - 2004.3

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    Country:Japan

  11. University of Iowa, Visiting researcher

    1999.7 - 2000.9

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    Country:United States

  12. 奈良県立医科大学助手(腫瘍放射線医学)

    1998.7 - 2002.5

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    Country:Japan

  13. 奈良県立奈良病院医長(放射線科)

    1997.4 - 1998.6

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    Country:Japan

  14. 奈良県立奈良病院医員(放射線科)

    1993.6 - 1997.3

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    Country:Japan

  15. 奈良県立医科大学助手(放射線医学)

    1992.7 - 1993.5

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    Country:Japan

  16. 奈良県立医科大学附属病院非常勤医員(放射線科)

    1991.5 - 1992.6

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    Country:Japan

  17. 奈良県立医科大学附属病院臨床研修医(放射線科)

    1989.5 - 1991.4

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    Country:Japan

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Education 1

  1. Nara Medical University   Faculty of Medicine

    1982.4 - 1989.3

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    Country: Japan

Professional Memberships 10

  1. International Society for Magnetic Resonance in Medicine   Annual Meeting Program Committee

    2012.11 - 2015.10

  2. Radiological Society of North America   Education Exhibits Committee

    2012.5 - 2018.12

  3. 日本神経放射線学会会員   評議員

    2012.2

  4. 日本医学放射線学会   代議員

    2010.4

  5. 日本磁気共鳴医学会会員   代議員

    2009.4

  6. 日本神経放射線学会会員

  7. 日本磁気共鳴医学会会員

  8. 日本医学放射線学会

  9. Radiological Society of North America

  10. International Society for Magnetic Resonance in Medicine

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Committee Memberships 8

  1. Radiological Society of North America Education Exhibits Committee   Member  

    2012.5 - 2018.12   

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    Committee type:Academic society

  2. International Society for Magnetic Resonance in Medicine, Annual Meeting Program Committee   member  

    2012.11 - 2015.5   

  3. 日本脳ドック学会-脳ドックのガイドライン検証・改訂委員会-無症候性脳梗塞,白質病変のMRI診断の標準化小委員会   委員  

    2005.10 - 2008.9   

  4.   MRI-QCコアメンバー  

    2007.7 - 2012.9   

  5. International Society for Magnetic Resonance in Medicine, Annual Meeting Program Committee   member  

    2012.11 - 2015.5   

  6. 国際磁気共鳴医学会プログラム委員会   委員  

    2012.11 - 2015.5   

  7. Radiological Society of North America Education Exhibits Committee   Member  

    2012.5 - 2018.12   

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    Committee type:Academic society

  8. 北米放射線学会学術展示委員会   委員  

    2012.5 - 2018.12   

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    Committee type:Academic society

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Awards 18

  1. Certificate of Merit, RSNA2019

    2019.12   The Radiological Society of North America  

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  2. Most Often Cited Paper Award, Japanese Journal of Radiology

    2019.4   Japan Radiological Societ  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  3. 教育展示優秀賞

    2018.4   日本医学放射線学会  

    田岡 俊昭

  4. Excellent Reviewer Award

    2017.4   「Japanese Journal of Radiology」誌  

    田岡 俊昭

  5. Best Invited Editor賞

    2016.4   「臨床画像」誌  

    田岡 俊昭

  6. 日本神経放射線学会優秀発表賞

    2016.2   日本神経放射線学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  7. 優秀発表賞

    2016.2   日本神経放射線学会  

    田岡 俊昭

  8. Certificate of Merit, RSNA2015

    2015.11   The Radiological Society of North America  

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  9. Certificate of Merit

    2015.11   北米放射線学会  

    田岡 俊昭

  10. MRMS Most Outstanding Reviewer

    2014.9  

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    Country:Japan

  11. 日本医学放射線学会Bronze Medal賞

    2009.4   日本医学放射線学会  

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    Country:Japan

  12. Certificate of Merit

    2008.11   RSNA  

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    Country:Japan

  13. 奈良県立医科大学中島佐一学術奨励賞

    2008.7   奈良県立医科大学  

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    Country:Japan

  14. 日本神経放射線学会加藤賞

    2007.2   日本神経放射線学会  

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    Country:Japan

  15. 日本神経放射線学会優秀発表賞

    2005.2   日本神経放射線学会  

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    Country:Japan

  16. 日本神経放射線学会優秀発表賞

    2003.2   日本神経放射線学会  

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    Country:Japan

  17. 日本神経放射線学会優秀発表賞

    2002.2   日本神経放射線学会  

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    Country:Japan

  18. 日本神経放射線学会優秀発表賞

    1999.2   日本神経放射線学会  

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    Country:Japan

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Papers 169

  1. Diffusion analysis of fluid dynamics with incremental strength of motion proving gradient (DANDYISM) to evaluate cerebrospinal fluid dynamics

    Taoka Toshiaki, Kawai Hisashi, Nakane Toshiki, Abe Takashi, Nakamichi Rei, Ito Rintaro, Sato Yuki, Sakai Mayuko, Naganawa Shinji

    JAPANESE JOURNAL OF RADIOLOGY   Vol. 39 ( 4 ) page: 315 - 323   2021.4

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    Publishing type:Research paper (scientific journal)   Publisher:Japanese Journal of Radiology  

    DOI: 10.1007/s11604-020-01075-4

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  2. Associations among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image along the Perivascular Space (DTI-ALPS) in Patients with Parkinson's Disease

    Chen Hsiu-Ling, Chen Pei-Chin, Lu Cheng-Hsien, Tsai Nai-Wen, Yu Chiun-Chieh, Chou Kun-Hsien, Lai Yun-Ru, Taoka Toshiaki, Lin Wei-Che

    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY   Vol. 2021   page: 4034509   2021.2

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    Publishing type:Research paper (scientific journal)   Publisher:Oxidative Medicine and Cellular Longevity  

    DOI: 10.1155/2021/4034509

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  3. Relationship between Time-dependent Signal Changes in Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space.

    Naganawa S, Ito R, Nakamichi R, Kawamura M, Taoka T, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021.1

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    Publishing type:Research paper (scientific journal)   Publisher:日本磁気共鳴医学会  

    <p>Purpose: To investigate the association between signal changes over time in perivenous cystic structures near the superior sagittal sinus and leakage of a gadolinium-based contrast agent (GBCA) into the subarachnoid space in patients with suspected endolymphatic hydrops.</p><p>Methods: Fifty-one cystic structures in 27 cases were evaluated. The signal intensity of the cystic structures was measured on 3D real inversion recovery (3D-real IR) images obtained at pre-, and at 10 min, 4 hrs and 24 hrs post-intravenous administration (IV) of GBCA. Signal enhancement of the cystic structures from the pre-contrast images at each time point was compared in subjects with leakage (positive) versus those without leakage (negative) using an ANOVA. Fisher's exact probability test was used to compare the maximum contrast-enhanced time point between positive and negative groups. We used 5% as a threshold to determine statistical significance.</p><p>Results: In leakage positive subjects, mean signal enhancement of the cysts was significantly greater at 4 and 24 hrs compared to 10 min. However, although there was a trend of an increase from 4 to 24 hrs, the difference was not significant. In the leakage negative group, mean signal enhancement of the cysts was significantly higher at 4 hrs compared to 10 min and 24 hrs. There was no significant difference between 10 min and 24 hrs. In the positive group, the maximum signal increase was found in 10/38 and 28/38 cysts at 4 and 24 hrs after IV-GBCA, respectively. In the leakage negative group, the maximum signal increase was found in 10/13 and 3/13 cysts at 4 and 24 hrs, respectively (<i>P</i> = 0.0019).</p><p>Conclusion: There was an association between signal changes over time after IV-GBCA in perivenous cystic structures and leakage of GBCA. Further research to clarify the impact of cystic structures on the function of the waste clearance system of the brain is warranted.</p>

    DOI: 10.2463/mrms.mp.2020-0138

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  4. Evaluating the Effect of Arterial Pulsation on Cerebrospinal Fluid Motion in the Sylvian Fissure of Patients with Middle Cerebral Artery Occlusion Using Low b-value Diffusion-weighted Imaging.

    Taoka T, Kawai H, Nakane T, Abe T, Nakamichi R, Ito R, Sasaki Y, Nishida A, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021.1

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    Publishing type:Research paper (scientific journal)   Publisher:日本磁気共鳴医学会  

    <p>Purpose: Decrease in signal of the cerebrospinal fluid (CSF) on low b-value diffusion weighted image (DWI) due to non-uniform flow can provide additional information regarding CSF motion. The purpose of the current study was to evaluate whether arterial pulsations constitute the driving force of CSF motion.</p><p>Methods: We evaluated the CSF signals within the Sylvian fissure on low b-value DWI in 19 patients with unilateral middle cerebral artery (MCA) occlusion. DWI with b-value of 500 s/mm<sup>2</sup> was evaluated for a decrease in CSF signal within the Sylvian fissure including the Sylvian vallecula and lower, middle, and higher Sylvian fissures and graded as follows: the same as contralateral side; smaller signal decrease than that on contralateral side; and no signal decrease. MR angiography (MRA) findings of MCA were graded as follows: the same as contralateral, lower signal than contralateral signal, and no signal. In 15 patients, regional cerebral blood flow (rCBF) was evaluated using single-photon emission computed tomography (SPECT) studies and graded as >90%, 90%–70%, and <70% rCBF compared to contralateral. The correlations between the gradings were evaluated using G likelihood-ratio test.</p><p>Results: There was no statistically significant correlation between the MRA and low b-value DWI gradings of CSF in all areas. There were statistically significant correlations between the decreases in CBF on SPECT and CSF signals in the middle Sylvian fissure.</p><p>Conclusion: The driving force of CSF pulsation in the Sylvian sinus may be related to the pulsations of the cerebral hemisphere rather than direct arterial pulsations.</p>

    DOI: 10.2463/mrms.mp.2020-0121

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  5. Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

    Taoka Toshiaki, Naganawa Shinji

    JAPANESE JOURNAL OF RADIOLOGY   Vol. 39 ( 1 ) page: 1 - 14   2021.1

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    Publishing type:Research paper (scientific journal)   Publisher:Japanese Journal of Radiology  

    DOI: 10.1007/s11604-020-01017-0

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  6. Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting

    Naganawa Shinji, Ito Rintaro, Kato Yutaka, Kawai Hisashi, Taoka Toshiaki, Yoshida Tadao, Maruyama Katsuya, Murata Katsutoshi, Koerzdoerfer Gregor, Pfeuffer Josef, Nittka Mathias, Sone Michihiko

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 20 ( 1 ) page: 91 - 98   2021

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    Publishing type:Research paper (scientific journal)   Publisher:Magnetic Resonance in Medical Sciences  

    <p>Purpose: To evaluate the feasibility for the detection of slight contrast effects after intravenous administration of single dose gadolinium-based contrast agent (IV-SD-GBCA), the time course of the GBCA distribution up to 24 h was examined in various fluid spaces and brain parenchyma using 3D-real IR imaging and MR fingerprinting (MRF).</p><p>Methods: Twenty-four patients with a suspicion of endolymphatic hydrops were scanned at pre-administration and at 10 min, 4 and 24 h post-IV-SD-GBCA. 3D-real IR images and MRF at the level of the internal auditory canal were obtained. The signal intensity on the 3D-real IR image of the cerebrospinal fluid (CSF) in the cerebellopontine angle cistern (CPA), Sylvian fissure (Syl), lateral ventricle (LV), and cochlear perilymph (CPL) was measured. The T<sub>1</sub> and T<sub>2</sub> values of cerebellar gray (GM) and white matter (WM) were measured using MRF. Each averaged value at the various time points was compared using an analysis of variance.</p><p>Results: The signal intensity on the 3D-real IR image in each CSF region peaked at 4 h, and was decreased significantly by 24 h (<i>P</i>< 0.05). All patients had a maximum signal intensity at 4 h in the CPA, and Syl. The mean CPL signal intensity peaked at 4 h and decreased significantly by 24 h (<i>P</i> < 0.05). All patients but two had a maximum signal intensity at 4 h. Regarding the T<sub>1</sub> value in the cerebellar WM and GM, the T<sub>1</sub> value at 10 min post-IV-GBCA was significantly decreased compared to the pre-contrast scan, but no significant difference was observed at the other time points. There was no significant change in T<sub>2</sub> in the gray or white matter at any of the time points.</p><p>Conclusion: Time course of GBCA after IV-SD-GBCA could be evaluated by 3D-real IR imaging in CSF spaces and in the brain by MRF.</p>

    DOI: 10.2463/mrms.mp.2020-0030

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  7. ISMRM2020における富樫かおり先生のGold Medal受賞と長縄慎二先生のSenior Fellow選出を記念して

    黒田 輝, 小畠 隆行, 三木 幸雄, 田岡 俊昭

    日本磁気共鳴医学会雑誌   Vol. 41 ( 1 ) page: 1 - 4   2021

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    Publishing type:Research paper (scientific journal)   Publisher:日本磁気共鳴医学会  

    <p> 2020年8月にウェブ開催されたISMRM(国際磁気共鳴医学会)において,京都大学の富樫かおり先生がGold Medalを受賞され,名古屋大学の長縄慎二先生がSenior Fellowに選出されました.同じ年の大会で日本人が同時に2名選出されることは初めてのことであり,MRI研究における日本の大きなプレゼンスを示す出来事でもありました.</p><p> この度,この快挙を記念して,お二人とご縁の深い先生方からの特別寄稿をいただきましたので,ここに掲載させて頂きます.</p>

    DOI: 10.2463/jjmrm.2020-1724

  8. The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging.

    Naganawa S, Taoka T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2020.11

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    Publishing type:Research paper (scientific journal)   Publisher:日本磁気共鳴医学会  

    <p>The central nervous system (CNS) was previously thought to be the only organ system lacking lymphatic vessels to remove waste products from the interstitial space. Recently, based on the results from animal experiments, the glymphatic system was hypothesized. In this hypothesis, cerebrospinal fluid (CSF) enters the periarterial spaces, enters the interstitial space of the brain parenchyma via aquaporin-4 (AQP4) channels in the astrocyte end feet, and then exits through the perivenous space, thereby clearing waste products. From the perivenous space, the interstitial fluid drains into the subarachnoid space and meningeal lymphatics of the parasagittal dura. It has been reported that the glymphatic system is particularly active during sleep. Impairment of glymphatic system function might be a cause of various neurodegenerative diseases such as Alzheimer's disease, normal pressure hydrocephalus, glaucoma, and others. Meningeal lymphatics regulate immunity in the CNS. Many researchers have attempted to visualize the function and structure of the glymphatic system and meningeal lymphatics <i>in vivo</i> using MR imaging. In this review, we aim to summarize these <i>in vivo</i> MR imaging studies and discuss the significance, current limitations, and future directions. We also discuss the significance of the perivenous cyst formation along the superior sagittal sinus, which is recently discovered in the downstream of the glymphatic system.</p>

    DOI: 10.2463/mrms.rev.2020-0122

    PubMed

  9. Increased Dendritic Orientation Dispersion in the Left Occipital Gyrus is Associated with Atypical Visual Processing in Adults with Autism Spectrum Disorder

    Matsuoka Kiwamu, Makinodan Manabu, Kitamura Soichiro, Takahashi Masato, Yoshikawa Hiroaki, Yasuno Fumihiko, Ishida Rio, Kishimoto Naoko, Yasuda Yuka, Hashimoto Ryota, Taoka Toshiaki, Miyasaka Toshiteru, Kichikawa Kimihiko, Kishimoto Toshifumi

    CEREBRAL CORTEX   Vol. 30 ( 11 ) page: 5617 - 5625   2020.11

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    Publishing type:Research paper (scientific journal)   Publisher:Cerebral Cortex  

    DOI: 10.1093/cercor/bhaa121

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  10. Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective

    Taoka Toshiaki, Naganawa Shinji

    KOREAN JOURNAL OF RADIOLOGY   Vol. 21 ( 11 ) page: 1199 - 1209   2020.11

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    Publishing type:Research paper (scientific journal)   Publisher:Korean Journal of Radiology  

    DOI: 10.3348/kjr.2020.0042

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  11. Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    FRONTIERS IN AGING NEUROSCIENCE   Vol. 12   page: 592469   2020.10

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    Publishing type:Research paper (scientific journal)   Publisher:Frontiers in Aging Neuroscience  

    DOI: 10.3389/fnagi.2020.592469

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  12. Change of White Matter Integrity in Children With Hematopoietic Stem Cell Transplantation

    Sakaguchi Yoko, Natsume Jun, Kidokoro Hiroyuki, Tanaka Masaharu, Okai Yu, Ito Yuji, Yamamoto Hiroyuki, Ohno Atsuko, Nakata Tomohiko, Nakane Toshiki, Kawai Hisashi, Taoka Toshiaki, Muramatsu Hideki, Naganawa Shinji, Takahashi Yoshiyuki

    PEDIATRIC NEUROLOGY   Vol. 111   page: 78 - 84   2020.10

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    Publishing type:Research paper (scientific journal)   Publisher:Pediatric Neurology  

    DOI: 10.1016/j.pediatrneurol.2020.06.008

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  13. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis

    Choy Shao Wei, Bagarinao Epifanio, Watanabe Hirohisa, Ho Eric Tatt Wei, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    HUMAN BRAIN MAPPING   Vol. 41 ( 12 ) page: 3198 - 3211   2020.8

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    Publishing type:Research paper (scientific journal)   Publisher:Human Brain Mapping  

    DOI: 10.1002/hbm.25008

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  14. Relationship between Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space around the Cortical Veins after Intravenous Administration.

    Naganawa S, Ito R, Nakamichi R, Kawamura M, Kawai H, Taoka T, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2020.7

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    Publishing type:Research paper (scientific journal)   Publisher:日本磁気共鳴医学会  

    <p>Purpose: The purpose of this retrospective study was to investigate the relationship between the number and size of cystic structures around the cortical veins near the superior sagittal sinus and the leakage of gadolinium-based contrast agent (GBCA) around the cortical veins.</p><p>Methods: Of 190 patients (91 male and 99 female), that were scanned at 4 h after an intravenous injection of GBCA as a diagnostic examination for endolymphatic hydrops, 6 patients with GBCA leakage were younger than the previously proposed threshold age of 37.3 years for leakage. Six age-matched patients without leakage were also included for reference. In addition, we included 8 cases without leakage that were older than the hypothesized threshold of 37.3 years, as well as 8 age-matched patients with GBCA leakage into the cerebrospinal fluid space. The number of cysts was counted and the sizes were measured in these 28 patients (age: 32–60 years old, 13 men and 15 women).</p><p>Results: The mean number of cysts surrounding the cortical veins in the parasagittal region was 4.29 ± 1.77 vs. 1.79 ± 1.05 (<i>P</i> = 0.0001) in the subjects with and without GBCA leakage, respectively. The mean size of the largest cysts was at 8.89 ± 3.49 mm vs. 5.69 ± 2.29 (<i>P</i> = 0.009) in the subjects with and without GBCA leakage, respectively.</p><p>Conclusion: The number and size of the perivenous cystic structures near the superior sagittal sinus is greater in subjects with GBCA leakage into the subarachnoid space compared with those without leakage. Future research regarding the histological and functional details of these parasagittal cystic structures is needed.</p>

    DOI: 10.2463/mrms.mp.2020-0062

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  15. Steroid-responsive recurrent tumefactive demyelination with multiple petechial hemorrhages along non-displaced medullary veins

    Tsuboi Takashi, Harada Yumiko, Suzuki Masashi, Ando Takashi, Atsuta Naoki, Ohka Fumiharu, Takeuchi Kazuhito, Taoka Toshiaki, Ohba Shigeo, Nakaguro Masato, Abe Masato, Nakashima Ichiro, Yoshida Mari, Katsuno Masahisa

    CLINICAL NEUROLOGY AND NEUROSURGERY   Vol. 193   page: 105764   2020.6

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    Publishing type:Research paper (scientific journal)   Publisher:Clinical Neurology and Neurosurgery  

    DOI: 10.1016/j.clineuro.2020.105764

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  16. White matter microstructural changes in tuberous sclerosis: Evaluation by neurite orientation dispersion and density imaging (NODDI) and diffusion tensor images

    Taoka Toshiaki, Aida Noriko, Fujii Yuta, Ichikawa Kazushi, Kawai Hisashi, Nakane Toshiki, Ito Rintaro, Naganawa Shinji

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 436   2020.1

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    Publishing type:Research paper (scientific journal)   Publisher:Scientific Reports  

    DOI: 10.1038/s41598-019-57306-w

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  17. Glymphatic imaging using MRI

    Taoka Toshiaki, Naganawa Shinji

    JOURNAL OF MAGNETIC RESONANCE IMAGING   Vol. 51 ( 1 ) page: 11 - 24   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jmri.26892

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  18. Comprehensive Evaluation of B<sub>1</sub><sup>+</sup>-corrected FISP-based Magnetic Resonance Fingerprinting: Accuracy, Repeatability and Reproducibility of T<sub>1</sub> and T<sub>2</sub> Relaxation Times for ISMRM/NIST System Phantom and Volunteers.

    Kato Y, Ichikawa K, Okudaira K, Taoka T, Kawaguchi H, Murata K, Maruyama K, Koerzdoerfer G, Pfeuffer J, Nittka M, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 3 ) page: 168 - 175   2020

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    DOI: 10.2463/mrms.mp.2019-0016

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  19. The Space between the Pial Sheath and the Cortical Venous Wall May Connect to the Meningeal Lymphatics.

    Naganawa S, Ito R, Taoka T, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 1 ) page: 1 - 4   2020

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    DOI: 10.2463/mrms.bc.2019-0099

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  20. Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting.

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 2 ) page: 141 - 146   2020

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    DOI: 10.2463/mrms.mp.2019-0048

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  21. Confirmation of Age-dependence in the Leakage of Contrast Medium around the Cortical Veins into Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agent

    Naganawa Shinji, Ito Rintaro, Kawai Hisashi, Taoka Toshiaki, Yoshida Tadao, Sone Michihiko

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 19 ( 4 ) page: 375 - 381   2020

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    <p>Purpose: It has been reported previously that intravenously administered gadolinium-based contrast agent (GBCA) leaks into the subarachnoid space around the cortical veins at 4 h after injection in all old people over 37 years, but not in younger people up to 37 years of age in 3D-real IR images. The purpose of this study was to investigate whether there was a strict threshold of 37 years of age for the leakage of the GBCA into the subarachnoid space.</p><p>Methods: The subjects included 190 patients, that were scanned for 3D-real IR images at 4 hours after intravenous injection of GBCA as a diagnostic test for endolymphatic hydrops. The patient's age ranged from 14 to 81 years. Two experienced neuroradiologists evaluated the images to determine whether the GBCA leakage around the cortical veins was positive or negative. Any discrepancies between the two observers were discussed and a consensus was obtained.</p><p>A Mann–Whitney <i>U</i> test and receiver operating characteristic (ROC) curve analysis were used to compare the positive and the negative group and to set the age cut-off value for the prediction of GBCA leakage.</p><p>Results: The GBCA leakage around the cortical veins was negative in 35 patients and positive in 155 patients. The average age was 33 ± 11 years in the negative group, and 55 ± 12 years in the positive group (<i>P</i> < 0.01). In the ROC analysis for the age and leakage of the GBCA, an area under the curve was 0.905 and the cut-off age was 37.317 years (sensitivity of 0.942 and specificity of 0.771).</p><p>Conclusion: Intravenously administered GBCA leaks into the subarachnoid space around the cortical veins in most patients over 37 years of age. However, it should be noted that it can be found occasionally in patients under 37 years of age.</p>

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  22. Computer-assisted cognitive remediation therapy for patients with schizophrenia induces microstructural changes in cerebellar regions involved in cognitive functions

    Matsuoka Kiwamu, Morimoto Tsubasa, Matsuda Yasuhiro, Yasuno Fumihiko, Taoka Toshiaki, Miyasaka Toshiteru, Yoshikawa Hiroaki, Takahashi Masato, Kitamura Soichiro, Kichikawa Kimihiko, Kishimoto Toshifumi

    PSYCHIATRY RESEARCH-NEUROIMAGING   Vol. 292   page: 41 - 46   2019.10

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    DOI: 10.1016/j.pscychresns.2019.09.001

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  23. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Ozaki Norio, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Sobue Gen

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 11352   2019.8

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    DOI: 10.1038/s41598-019-47922-x

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  24. Increased signal intensity of low-concentration gadolinium contrast agent by longer repetition time in heavily T-2-weighted-3D-FLAIR

    Kato Yutaka, Bokura Kiminori, Taoka Toshiaki, Naganawa Shinji

    JAPANESE JOURNAL OF RADIOLOGY   Vol. 37 ( 5 ) page: 431 - 435   2019.5

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    DOI: 10.1007/s11604-019-00828-0

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  25. Can low b value diffusion weighted imaging evaluate the character of cerebrospinal fluid dynamics?

    Taoka T, Naganawa S, Kawai H, Nakane T, Murata K

    Japanese journal of radiology   Vol. 37 ( 2 ) page: 135-144   2019.2

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    DOI: 10.1007/s11604-018-0790-8

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  26. Improved 3D-real Inversion Recovery: A Robust Imaging Technique for Endolymphatic Hydrops after Intravenous Administration of Gadolinium

    Naganawa Shinji, Kawai Hisashi, Taoka Toshiaki, Sone Michihiko

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 18 ( 1 ) page: 105-108   2019

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    DOI: 10.2463/mrms.bc.2017-0158

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  27. Inter-individual Comparison of Gadobutrol and Gadoteridol Tissue Time-intensity Profiles for Dynamic Susceptibility Contrast Perfusion MR Imaging

    Yamada Masahiro, Taoka Toshiaki, Kawaguchi Ai, Yasuda Kenji, Niinomi Yasushi, Ohashi Yoichi, Okuda Takahito, Naganawa Shinji

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 18 ( 1 ) page: 75-81   2019

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    DOI: 10.2463/mrms.mp.2017-0172

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  28. Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging.

    Naganawa S, Nakane T, Kawai H, Taoka T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.11

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  29. PREDICTION OF INTRACRANIAL ARTERIAL STENOSIS PROGRESSION IN PATIENTS WITH MOYAMOYA VASCULOPATHY: CONTRAST-ENHANCED HIGH-RESOLUTION MAGNETIC RESONANCE VESSELWALL IMAGING

    Muraoka S., Araki Y., Taoka T., Kawai H., Okamoto S., Uda K., Ota S., Naganawa S., Wakabayashi T.

    INTERNATIONAL JOURNAL OF STROKE   Vol. 13   page: 32-32   2018.10

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  30. Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy

    Hara Kazuhiro, Watanabe Hirohisa, Bagarinao Epifanio, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Tsuboi Takashi, Ito Mizuki, Atsuta Naoki, Niwa Hisayoshi, Taoka Toshiaki, Maesawa Satoshi, Naganawa Shinji, Katsuno Masahisa, Sobue Gen

    JOURNAL OF NEUROLOGY   Vol. 265 ( 9 ) page: 2079-2087   2018.9

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    DOI: 10.1007/s00415-018-8923-7

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  31. Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain Observations by Dynamic MRI and Effect of Circadian Rhythm on Tissue Gadolinium Concentrations

    Taoka Toshiaki, Jost Gregor, Frenzel Thomas, Naganawa Shinji, Pietsch Hubertus

    INVESTIGATIVE RADIOLOGY   Vol. 53 ( 9 ) page: 529-534   2018.9

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    DOI: 10.1097/RLI.0000000000000473

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  32. Prediction of Intracranial Arterial Stenosis Progression in Patients with Moyamoya Vasculopathy: Contrast-Enhanced High-Resolution Magnetic Resonance Vessel Wall Imaging

    Muraoka Shinsuke, Araki Yoshio, Taoka Toshiaki, Kawai Hisashi, Okamoto Sho, Uda Kenji, Ota Shinji, Naganawa Shinji, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   Vol. 116   page: E1114-E1121   2018.8

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    DOI: 10.1016/j.wneu.2018.05.181

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  33. A guide to identification and selection of axial planes in magnetic resonance imaging of the brain

    Otake Shoichiro, Taoka Toshiaki, Maeda Masayuki, Yuh William T. C.

    NEURORADIOLOGY JOURNAL   Vol. 31 ( 4 ) page: 336-344   2018.8

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    DOI: 10.1177/1971400918769911

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  34. Imaging Differences between Neuromyelitis Optica Spectrum Disorders and Multiple Sclerosis: A Multi-Institutional Study in Japan Reviewed

    H. Tatekawa, S. Sakamoto, M. Hori, Y. Kaichi, A. Kunimatsu, K. Akazawa, T. Miyasaka, H. Oba, T. Okubo, K. Hasuo, K. Yamada, T. Taoka, S. Doishita, T. Shimono, Y. Miki

    American Journal of Neuroradiology   Vol. 39 ( 7 ) page: 1239 - 1247   2018.7

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    DOI: 10.3174/ajnr.A5663

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  35. Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial

    Morimoto Tsubasa, Matsuda Yasuhiro, Matsuoka Kiwamu, Yasuno Fumihiko, Ikebuchi Emi, Kameda Hiroyuki, Taoka Toshiaki, Miyasaka Toshiteru, Kichikawa Kimihiko, Kishimoto Toshifumi

    BMC PSYCHIATRY   Vol. 18 ( 1 ) page: 83   2018.3

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    DOI: 10.1186/s12888-018-1667-1

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  36. Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain.

    Taoka T, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.1

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    DOI: 10.2463/mrms.rev.2017-0116

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  37. Differences in Signal Intensity and Enhancement on MR Images of the Perivascular Spaces in the Basal Ganglia versus Those in White Matter.

    Naganawa S, Nakane T, Kawai H, Taoka T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.1

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    DOI: 10.2463/mrms.mp.2017-0137

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  38. Single-stage Coil Embolization for Kissing Aneurysms of the Internal Carotid Artery Using Enterprise Stent: Three Cases Reports Reviewed

    Takeshi Wada, Katsutoshi Takayama, Toshiaki Taoka, Kaoru Myouchin, Hiroyuki Nakagawa, Ichiro Nakagawa, Toshiteru Miyasaka, Shinichiro Kurokawa, Kimihiko Kichikawa

    Journal of Neuroendovascular Therapy   Vol. 12 ( 1 ) page: 6   2018

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    DOI: 10.5797/jnet.oa.2017-0017

  39. Appearance of the Organum Vasculosum of the Lamina Terminalis on Contrast-enhanced MR Imaging.

    Naganawa S, Taoka T, Kawai H, Yamazaki M, Suzuki K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2017.9

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    DOI: 10.2463/mrms.mp.2017-0088

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  40. Diffusion tensor tractography in the preoperative precise identification of the course of facial nerve in a meningioma of the cerebellopontine angle - Technical implications

    d'Almeida Goncalo Neto, Marques Luis Sousa, Escada Pedro, Taoka Toshiaki, Pereira Pedro Goncalves

    INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT   Vol. 9   page: 58-60   2017.9

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    DOI: 10.1016/j.inat.2017.03.010

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  41. Efficacy and safety of non-suture dural closure using a novel dural substitute consisting of polyglycolic acid felt and fibrin glue to prevent cerebrospinal fluid leakage-A non-controlled, open-label, multicenterclinical trial-

    Terasaka Shunsuke, Taoka Toshiaki, Kuroda Satoshi, Mikuni Nobutaka, Nishi Toru, Nakase Hiroyuki, Fujii Yukihiko, Hayashi Yasuhiko, Murata Jun-ichi, Kikuta Ken-ichiro, Kuroiwa Toshihiko, Shimokawa Sachie, Houkin Kiyohiro

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE   Vol. 28 ( 5 ) page: 69   2017.5

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    DOI: 10.1007/s10856-017-5877-8

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  42. Carotid Artery Stenting Investigation of Plaque Protrusion Incidence and Prognosis Reviewed

    Masashi Kotsugi, Katsutoshi Takayama, Kaoru Myouchin, Takeshi Wada, Ichiro Nakagawa, Hiroyuki Nakagawa, Toshiaki Taoka, Shinichiro Kurokawa, Hiroyuki Nakase, Kimihiko Kichikawa

    JACC-CARDIOVASCULAR INTERVENTIONS   Vol. 10 ( 8 ) page: 824 - 831   2017.4

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    OBJECTIVES This study sought to clarify the incidence and prognosis of PP in carotid artery stenting (CAS).
    BACKGROUND Projections thought to be plaque may be observed inside the stent on angiography or intravascular ultrasound (IVUS) during CAS. Known as plaque protrusion (PP), the incidence and prognosis of this complication are unclear.
    METHODS A total of 354 consecutive carotid atherosclerotic stenoses in 328 patients (285 men, 43 women; age range 51 to 97 years [mean age 73.6 years]; 158 symptomatic cases; stenosis rate, 50% to 99% [mean 81.0%]) who underwent CAS under IVUS between October 2007 and March 2016 were retrospectively analyzed. PP was defined as plaque seen inside the stent lumen on both digital subtraction angiography and IVUS. The incidence and prognosis (rate of stroke within 30 post-operative days) of PP and the rate of ischemic lesions on the treated side on diffusion-weighted imaging performed within 48 post-operative hours within the PP group were investigated.
    RESULTS PP was observed in 9 cases (2.6%). Ischemic stroke occurred in 6 of 9 PP cases (66.7%; 1 major, 5 minor). Ischemic lesions were observed on diffusion-weighted imaging in 8 of 9 cases (88.9%). PP was strongly associated with perioperative ischemic stroke. A significant increase in PP susceptibility was observed with open-cell stent use and unstable plaque.
    CONCLUSIONS The incidence of PP in CAS was 2.6%, with a high risk of ischemic complications if PP was observed. The present findings indicate the necessity of appropriate device selection to avoid PP. (C) 2017 by the American College of Cardiology Foundation.

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  43. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Reviewed

    Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F, Kishimoto T, Naganawa S

    Japanese journal of radiology     2017.2

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    DOI: 10.1007/s11604-017-0617-z

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  44. Lack of Contrast Enhancement in a Giant Perivascular Space of the Basal Ganglion on Delayed FLAIR Images: Implications for the Glymphatic System. Reviewed

    Naganawa S, Nakane T, Kawai H, Taoka T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2017.1

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    DOI: 10.2463/mrms.ci.2016-0114

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  45. Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia. Reviewed

    Naganawa S, Nakane T, Kawai H, Taoka T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 16 ( 1 ) page: 61-65   2017.1

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    DOI: 10.2463/mrms.mp.2016-0039

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  46. Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders. Reviewed

    Taoka T, Fukusumi A, Miyasaka T, Kawai H, Nakane T, Kichikawa K, Naganawa S

    Radiographics : a review publication of the Radiological Society of North America, Inc   Vol. 37 ( 1 ) page: 281-297   2017.1

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    DOI: 10.1148/rg.2017160061

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  47. Revisiting Current Golden Rules in Managing Acute Ischemic Stroke: Evaluation of New Strategies to Further Improve Treatment Selection and Outcome Reviewed

    William T. C. Yuh, Matthew David Alexander, Toshihiro Ueda, Masayuki Maeda, Toshiaki Taoka, Kei Yamada, Norman J. Beauchamp

    AMERICAN JOURNAL OF ROENTGENOLOGY   Vol. 208 ( 1 ) page: 32 - 41   2017.1

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    OBJECTIVE. Advanced stroke imaging has generated much excitement for the early diagnosis of acute ischemic stroke (AIS) and facilitation of intervention. However, its therapeutic impact has not matched its diagnostic utility; most notably, lacking significant contributions to recent major AIS clinical trials. It is time to reexamine the fundamental hypotheses from the enormous body of imaging research on which clinical practices are based and reassess the current standard clinical and imaging strategies, or golden rules, established over decades for AIS. In this article, we will investigate a possible new window of opportunity in managing AIS through a better understanding of the following: first, the potential limitations of the golden rules; second, the significance of imaging-based parenchymal hypoperfusion (i.e., lower-thannormal relative cerebral blood flow [rCBF] may not be indicative of ischemia); third, the other critical factors (e.g., rCBF, collateral circulation, variable therapeutic window, chronicity of occlusion) that reflect more individual ischemic injury for optimal treatment selection; and, fourth, the need for penumbra validation in successfully reperfused patients (not in untreated patients).
    CONCLUSION. Individual variations in the therapeutic window, ischemic injury (rCBF), and chronicity of vascular lesion development have not been comprehensively incorporated in the standard algorithms used to manage AIS. The current established imaging parameters have not been consistently validated with successfully reperfused patients and rCBF to quantitatively distinguish between oligemia and ischemia and between penumbra and infarct core within ischemic tissue. A novel paradigm incorporating rCBF values or indirectly incorporating relative rCBF values with higher statistically powered imaging studies to more reliably assess the severity of ischemic injury and differentiate reversibility from viability within the area of imaging-based parenchymal hypoperfusion may provide a more personalized approach to treatment, including no treatment of infarction core, to further enhance outcomes.

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  48. Improved HYDROPS: Imaging of Endolymphatic Hydrops after Intravenous Administration of Gadolinium

    Naganawa Shinji, Kawai Hisashi, Taoka Toshiaki, Sone Michihiko

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 16 ( 4 ) page: 357-361   2017

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    DOI: 10.2463/mrms.tn.2016-0126

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  49. Structures Showing Negative Correlations of Signal Intensity with Postnatal Age on T-1-weighted Imaging of the Brain of Newborns and Infants

    Hori Saeka, Taoka Toshiaki, Ochi Tomoko, Miyasaka Toshiteru, Sakamoto Masahiko, Takayama Katsutoshi, Wada Takeshi, Myochin Kaoru, Takahashi Yukihiro, Kichikawa Kimihiko

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 16 ( 4 ) page: 333-339   2017

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    DOI: 10.2463/mrms.mp.2015-0168

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  50. Diffusion Tensor Imaging in Dementia Reviewed

    Taoka Toshiaki

    Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias     page: 117 - 128   2017

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    DOI: 10.1007/978-4-431-55133-1_5

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  51. Application of histogram analysis for the evaluation of vascular permeability in glioma by the K2 parameter obtained with the dynamic susceptibility contrast method: Comparisons with Ktrans obtained with the dynamic contrast enhance method and cerebral blood volume. Reviewed

    Taoka T, Kawai H, Nakane T, Hori S, Ochi T, Miyasaka T, Sakamoto M, Kichikawa K, Naganawa S

    Magnetic resonance imaging   Vol. 34 ( 7 ) page: 896-901   2016.9

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    DOI: 10.1016/j.mri.2016.04.020

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  52. Advantages of Diffusion Tensor Tractography of Facial Nerve in Vestibular Schwannomas Surgeries: A Multicenter Study Reviewed

    Gon{\c{c } }alo Almeida, Pedro Pereira, Luis Marques, Pedro Escada, Kimihiko Kichikawa, Shinji Naganawa, Toshiaki Taoka

    Journal of Neurological Surgery Part B: Skull Base   Vol. 77 ( S 02 )   2016.9

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    DOI: 10.1055/s-0036-1592566

  53. Cochlear Lymph Fluid Signal Increase in Patients with Otosclerosis after Intravenous Administration of Gadodiamide. Reviewed

    Naganawa S, Kawai H, Taoka T, Suzuki K, Iwano S, Satake H, Sone M, Ikeda M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 15 ( 3 ) page: 308-15   2016.7

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    DOI: 10.2463/mrms.mp.2015-0121

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  54. Diffusion tensor studies and voxel-based morphometry of the temporal lobe to determine the cognitive prognosis in cases of Alzheimer's disease and mild cognitive impairment: Do white matter changes precede gray matter changes? Reviewed

    Taoka T, Yasuno F, Morikawa M, Inoue M, Kiuchi K, Kitamura S, Matsuoka K, Kishimoto T, Kichikawa K, Naganawa S

    SpringerPlus   Vol. 5 ( 1 ) page: 1023   2016.7

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    DOI: 10.1186/s40064-016-2692-5

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  55. Visualization of Middle Ear Ossicles in Elder Subjects with Ultra-short Echo Time MR Imaging. Reviewed

    Naganawa S, Nakane T, Kawai H, Taoka T, Suzuki K, Iwano S, Satake H, Grodzki D

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2016.3

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    DOI: 10.2463/mrms.mp.2015-0171

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  56. Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model

    Taoka Toshiaki, Fujioka Masayuki, Kashiwagi Yuto, Obata Atsushi, Rokugawa Takemi, Hori Masaaki, Masutani Yoshitaka, Aoki Shigeki, Naganawa Shinji, Abe Kohji

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   Vol. 25 ( 3 ) page: 610-617   2016.3

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    DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.028

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  57. Progress in magnetic resonance diffusion image Reviewed

    Toshiaki Taoka

    Japanese Journal of Neurosurgery   Vol. 25 ( 5 ) page: 402 - 410   2016

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    Diffusion of water is based on the principle that water molecules show random motion. In diffusion studies on magnetic resonance imaging using a motion proving gradient, a signal decrease which is caused by molecular diffusion in the tissue provides information about tissue structure and physiological status. Diffusion-weighted images play a very important role in brain related diagnosis, especially for acute infarctions, and have become an essential tool in clinical practice. Diffusion tensor imaging using the Gaussian distribution model also has made strides in evaluating anisotropic water diffusion in the white matter in which water diffusion is restricted by macromolecules, membrane, and myelin. Diffusion tensor imaging is based on a mathematical model of an ellipsoid. Thus principal directions of diffusion and the magnitude of diffusion along those directions can be calculated. Diffusion tensor tractography is an innovative application of the diffusion tensor method which can access the pathways of neuronal fibers. However, neuronal tissue is a highly heterogeneous structure on various scales and the Gaussian distribution has only been adapted for free diffusion in a fluid that is uniform and sufficiently large. Complicated wall structures exist in the neuronal tissue, and the Gaussian distribution model does not reflect the existence of a large number of compartments and nerve tracts, particularly in the central nervous system. Therefore, instead of a simple Gaussian distribution model, measurement of the probability distribution of a detailed water molecule is necessary. One method is q-space imaging (QSI). QSI is performed by measuring a large amount of diffusion encoding and can provide the probability density function of individual water molecules. Although QSI is theoretically superior to conventional Gaussian distribution analysis, one limitation of QSI is the long acquisition time due to the large sampling number. The concept of kurtosis is another method to evaluate non-Gaussianity. Kurtosis is a quantity that reflects a gap between the diffusion distribution of a water molecule in vivo and the Gaussian distribution, and can be calculated from datasets of relatively few diffusion encoding elements compared to QSI. Thus, a rather short acquisition time is required for kurtosis. Recently, other innovative applications of non-Gaussian diffusion have been introduced including neurite orientation dispersion and density imaging (NODDI) which is a model-based diffusion technique that allows for the quantification of specific microstructural features directly related to neuronal morphology. These novel techniques will provide useful information on tissue microstructure not only in the scientific research but also in the clinical practice.

    DOI: 10.7887/jcns.25.402

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  58. Enterprise Stent-assisted Cerebral Aneurysm Coiling: Can Antiplatelet Therapy be Terminated after Neointima Formation with the Enterprise Stent? Reviewed

    Katsutoshi Takayama, Toshiaki Taoka, Kaoru Myouchin, Takeshi Wada, Hiroyuki Nakagawa, Ichiro Nakagawa, Toshiteru Miyasaka, Masahiko Sakamoto, Shinichiro Kurokawa, Kimihiko Kichikawa

    Journal of Neuroendovascular Therapy   Vol. 10 ( 4 ) page: 201   2016

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    DOI: 10.5797/jnet.oa.2016-0052

  59. Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model Reviewed

    Taoka T, Fujioka M, Kashiwagi Y, Obata A, Rokugawa T, Hori M, Masutani Y, Aoki S, Naganawa S, Abe K.

    J Stroke Cerebrovasc Dis.     2015.12

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    DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.028.

  60. Heavily T2-Weighted 3D-FLAIR Improves the Detection of Cochlear Lymph Fluid Signal Abnormalities in Patients with Sudden Sensorineural Hearing Loss. Reviewed

    Naganawa S, Kawai H, Taoka T, Suzuki K, Iwano S, Satake H, Sone M, Ikeda M.

    Magn Reson Med Sci.     2015.11

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    DOI: 10.2463/mrms.mp.2015-0065

  61. Dural Thickening of the Internal Auditory Canal in Patients With Spontaneous Intracranial Hypotension Syndrome. Reviewed

    Hori S, Taoka T, Miyasaka T, Ochi T, Sakamoto M, Wada T, Myochin K, Takayama K, Kichikawa K.

        2015.11

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    DOI: 10.1097/RCT.0000000000000342

  62. A case of meningococcal meningitis with multiple cerebellar microbleeds detected by susceptibility-weighted imaging.

    Miyazaki K, Fukushima H, Kogeichi Y, Watanabe T, Norimoto K, Taoka T, Okuchi K.

    BMC Med Imaging.     2015.10

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    DOI: 10.1186/s12880-015-0090-z

  63. Characteristic Mill findings of upper limb muscle involvement in myotonic dystrophy type 1 Reviewed

    K. Sugie, M. Sugie, T. Taoka, Y. Tonomura, A. Kumazawa, T. Izumi, S. Ueno, K. Kichikawa

    NEUROMUSCULAR DISORDERS   Vol. 25   page: S272 - S272   2015.10

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    DOI: 10.1016/j.nmd.2015.06.312

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  64. Utility of High-b-Value Diffusion-Weighted Magnetic Resonance Imaging in Evaluating Reversible Medial Longitudinal Fasciculus Syndrome Caused by Acute Brainstem Ischemia.

    Miki Y, Fujioka M, Taoka T, Tanaka H, Chitoku S, Matsuyama T, Tanaka S

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   Vol. 24 ( 6 ) page: e157-9   2015.6

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    DOI: 10.1016/j.jstrokecerebrovasdis.2015.03.002

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  65. Characteristic MRI Findings of upper Limb Muscle Involvement in Myotonic Dystrophy Type 1 Reviewed

    Sugie K, Sugie M, Taoka T, Tonomura Y, Kumazawa A, Izumi T, Kichikawa K, Ueno S.

    PLoS One.   Vol. 10 ( 4 ) page: e0125051   2015.4

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    DOI: 10.1371/journal.pone.0125051.

  66. "Cerebellar peduncle quarter notes" formed by the superior and middle cerebellar peduncles: comparison with a diffusion tensor study of spinocerebellar degeneration.

    Ochi T, Taoka T, Miyasaka T, Wada T, Sakamoto M, Hori S, Kichikawa K

    Japanese journal of radiology   Vol. 33 ( 4 ) page: 210-5   2015.4

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    DOI: 10.1007/s11604-015-0409-2

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  67. Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of stroke recurrence and longitudinal progression of white matter lesions and silent brain infarcts on MRI (CEREBRAL study): rationale, design, and methodology.

    Yamano S, Horii M, Takami T, Sakuma M, Morimoto T, Okada S, Taoka T, Kichikawa K, Sasamura H, Itoh H, Furuya Y, Ueno S, Imamura T, Sugiyama S, Ogawa H, Saito Y

    International journal of stroke : official journal of the International Stroke Society   Vol. 10 ( 3 ) page: 452-6   2015.4

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    DOI: 10.1111/ijs.12085

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  68. Characteristic MRI Findings of upper Limb Muscle Involvement in Myotonic Dystrophy Type 1 Reviewed

    Kazuma Sugie, Miho Sugie, Toshio Taoka, Yasuyo Tonomura, Aya Kumazawa, Tesseki Izumi, Kimihiko Kichikawa, Satoshi Ueno

    PLOS ONE   Vol. 10 ( 4 ) page: e0125051   2015.4

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    The objective of our study was to evaluate the relation between muscle MRI findings and upper limb weakness with grip myotonia in patients with myotonic dystrophy type 1 (DM1). Seventeen patients with DM1 were evaluated by manual muscle strength testing and muscle MRI of the upper limbs. Many DM1 patients presenting with decreased grasping power frequently showed high intensity signals in the flexor digitorum profundus (FDP) muscles on T1-weighted imaging. Patients presenting with upper limb weakness frequently also showed high intensity signals in the flexor pollicis longus, abductor pollicis longus, and extensor pollicis muscles. Disturbances of the distal muscles of the upper limbs were predominant in all DM1 patients. Some DM1 patients with a prolonged disease duration showed involvement of not only distal muscles but also proximal muscles in the upper limbs. Muscle involvement of the upper limbs on MRI strongly correlated positively with the disease duration or the numbers of CTG repeats. To our knowledge, this is the first study to provide a detailed description of the distribution and severity of affected muscles of the upper limbs on MRI in patients with DM1. We conclude that muscle MRI findings are very useful for identifying affected muscles and predicting the risk of muscle weakness in the upper limbs of DM1 patients.

    DOI: 10.1371/journal.pone.0125051

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    PubMed

  69. A magnetic resonance imaging technique to evaluate tumor-brain adhesion in meningioma: brain-surface motion imaging.

    Yamada S, Taoka T, Nakagawa I, Nishimura F, Motoyama Y, Park YS, Nakase H, Kichikawa K

    World neurosurgery   Vol. 83 ( 1 ) page: 102-7   2015.1

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    DOI: 10.1016/j.wneu.2013.02.015

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  70. Time course of axial and radial diffusion kurtosis of white matter infarctions: period of pseudonormalization.

    Taoka T, Fujioka M, Sakamoto M, Miyasaka T, Akashi T, Ochi T, Hori S, Uchikoshi M, Xu J, Kichikawa K

    AJNR. American journal of neuroradiology   Vol. 35 ( 8 ) page: 1509-14   2014.8

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    DOI: 10.3174/ajnr.A3908

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  71. Comparison of brain 3.0-T with 1.5-T MRI in patients with multiple sclerosis: a 6-month follow-up study.

    Kataoka H, Kiriyama T, Taoka T, Oba N, Takewa M, Eura N, Syobatake R, Kobayashi Y, Kumazawa M, Izumi T, Furiya Y, Aoyama N, Kichikawa K, Ueno S

    Clinical neurology and neurosurgery   Vol. 121   page: 55-8   2014.6

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    DOI: 10.1016/j.clineuro.2014.03.018

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  72. Long-term treatment outcomes after intravascular ultrasound evaluation and stent placement for atherosclerotic subclavian artery obstructive lesions.

    Wada T, Takayama K, Taoka T, Nakagawa H, Myouchin K, Miyasaka T, Akashi T, Sakamoto M, Kichikawa K

    The neuroradiology journal   Vol. 27 ( 2 ) page: 213-21   2014.4

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  73. Cerebellar dentate nucleus in progressive supranuclear palsy.

    Sawa N, Kataoka H, Kiriyama T, Izumi T, Taoka T, Kichikawa K, Ueno S

    Clinical neurology and neurosurgery   Vol. 118   page: 32-6   2014.3

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    DOI: 10.1016/j.clineuro.2013.12.011

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  74. Decision-making deficit of a patient with axonal damage after traumatic brain injury.

    Yasuno F, Matsuoka K, Kitamura S, Kiuchi K, Kosaka J, Okada K, Tanaka S, Shinkai T, Taoka T, Kishimoto T

    Brain and cognition   Vol. 84 ( 1 ) page: 63-8   2014.2

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    DOI: 10.1016/j.bandc.2013.11.005

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  75. Gray and white matter changes in subjective cognitive impairment, amnestic mild cognitive impairment and Alzheimer's disease: a voxel-based analysis study.

    Kiuchi K, Kitamura S, Taoka T, Yasuno F, Tanimura M, Matsuoka K, Ikawa D, Toritsuka M, Hashimoto K, Makinodan M, Kosaka J, Morikawa M, Kichikawa K, Kishimoto T

    PloS one   Vol. 9 ( 8 ) page: e104007   2014

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    DOI: 10.1371/journal.pone.0104007

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  76. Comparison between two separate injections and a single injection of double-dose contrast medium for contrast-enhanced MR imaging of metastatic brain tumors.

    Ochi T, Taoka T, Matsuda R, Sakamoto M, Akashi T, Tamamoto T, Sugimoto T, Sakaguchi H, Hasegawa M, Nakase H, Kichikawa K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 13 ( 4 ) page: 221-9   2014

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    DOI: 10.2463/mrms.2013-0068

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  77. A mismatch between the abnormalities in diffusion- and susceptibility-weighted magnetic resonance imaging may represent an acute ischemic penumbra with misery perfusion.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   Vol. 22 ( 8 ) page: 1428-31   2013.11

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    DOI: 10.1016/j.jstrokecerebrovasdis.2012.12.009

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  78. Longitudinal white matter changes in Alzheimer's disease: a tractography-based analysis study.

    Kitamura S, Kiuchi K, Taoka T, Hashimoto K, Ueda S, Yasuno F, Morikawa M, Kichikawa K, Kishimoto T

    Brain research   Vol. 1515   page: 12-8   2013.6

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    DOI: 10.1016/j.brainres.2013.03.052

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  79. The use of susceptibility-weighted imaging as an indicator of retrograde leptomeningeal venous drainage and venous congestion with dural arteriovenous fistula: diagnosis and follow-up after treatment.

    Nakagawa I, Taoka T, Wada T, Nakagawa H, Sakamoto M, Kichikawa K, Hironaka Y, Motoyama Y, Park YS, Nakase H

    Neurosurgery   Vol. 72 ( 1 ) page: 47-54; discussion 55   2013.1

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    DOI: 10.1227/NEU.0b013e318276f7cc

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  80. Carotid Wallstent placement difficulties encountered in carotid artery stenting.

    Myouchin K, Takayama K, Taoka T, Nakagawa H, Wada T, Sakamoto M, Iwasaki S, Kurokawa S, Kichikawa K

    SpringerPlus   Vol. 2   page: 468   2013

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    DOI: 10.1186/2193-1801-2-468

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  81. Obstacles encountered during transradial angiography from after Radial Artery puncture to the aortic arch.

    Iwasaki S, Yokoyama K, Furuichi K, Okada H, Ohkura A, Ide K, Takayama K, Taoka T, Kichikawa K

    SpringerPlus   Vol. 2   page: 365   2013

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    DOI: 10.1186/2193-1801-2-365

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  82. Unilateral oculomotor nerve palsy as an initial presentation of bilateral chronic subdural hematoma: case report.

    Matsuda R, Hironaka Y, Kawai H, Park YS, Taoka T, Nakase H

    Neurologia medico-chirurgica   Vol. 53 ( 9 ) page: 616-9   2013

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  83. Accuracy for predicting adhesion between meningioma and the brain by using brain surface motion imaging: comparison between single and double acquisition methods.

    Taoka T, Yamada S, Sakamoto M, Akashi T, Miyasaka T, Ochi T, Wada T, Uchikoshi M, Nakase H, Kichikawa K

    Neuroradiology   Vol. 54 ( 12 ) page: 1313-20   2012.12

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    DOI: 10.1007/s00234-012-1054-4

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  84. Effect of cilostazol in preventing restenosis after carotid artery stenting using the carotid wallstent: a multicenter retrospective study.

    Takayama K, Taoka T, Nakagawa H, Myouchin K, Wada T, Sakamoto M, Furuichi K, Iwasaki S, Kurokawa S, Kichikawa K

    AJNR. American journal of neuroradiology   Vol. 33 ( 11 ) page: 2167-70   2012.12

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    DOI: 10.3174/ajnr.A3127

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  85. Brain structural changes and neuropsychological impairments in male polydipsic schizophrenia.

    Nagashima T, Inoue M, Kitamura S, Kiuchi K, Kosaka J, Okada K, Kishimoto N, Taoka T, Kichikawa K, Kishimoto T

    BMC psychiatry   Vol. 12   page: 210   2012.11

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    DOI: 10.1186/1471-244X-12-210

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  86. Application of susceptibility weighted imaging (SWI) for evaluation of draining veins of arteriovenous malformation: utility of magnitude images.

    Miyasaka T, Taoka T, Nakagawa H, Wada T, Takayama K, Myochin K, Sakamoto M, Ochi T, Akashi T, Kichikawa K

    Neuroradiology   Vol. 54 ( 11 ) page: 1221-7   2012.11

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    DOI: 10.1007/s00234-012-1029-5

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  87. Branching pattern of lenticulostriate arteries observed by MR angiography at 3.0 T.

    Akashi T, Taoka T, Ochi T, Miyasaka T, Wada T, Sakamoto M, Takewa M, Kichikawa K

    Japanese journal of radiology   Vol. 30 ( 4 ) page: 331-5   2012.5

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    DOI: 10.1007/s11604-012-0058-7

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  88. Diffuse vascular injury: convergent-type hemorrhage in the supratentorial white matter on susceptibility-weighted image in cases of severe traumatic brain damage.

    Iwamura A, Taoka T, Fukusumi A, Sakamoto M, Miyasaka T, Ochi T, Akashi T, Okuchi K, Kichikawa K

    Neuroradiology   Vol. 54 ( 4 ) page: 335-43   2012.4

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    DOI: 10.1007/s00234-011-0892-9

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  89. Comparison of computed tomography myelography and radioisotope cisternography to detect cerebrospinal fluid leakage in spontaneous intracranial hypotension.

    Hashizume K, Watanabe K, Kawaguchi M, Taoka T, Shinkai T, Furuya H

    Spine   Vol. 37 ( 4 ) page: E237-42   2012.2

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    DOI: 10.1097/BRS.0b013e31822e606a

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  90. Visualizing non-Gaussian diffusion: clinical application of q-space imaging and diffusional kurtosis imaging of the brain and spine.

    Hori M, Fukunaga I, Masutani Y, Taoka T, Kamagata K, Suzuki Y, Aoki S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 11 ( 4 ) page: 221-33   2012

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  91. Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study.

    Kitamura S, Morikawa M, Kiuchi K, Taoka T, Fukusumi M, Kichikawa K, Kishimoto T

    BMC research notes   Vol. 4   page: 378   2011.10

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    DOI: 10.1186/1756-0500-4-378

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  92. Usefulness of contrast-enhanced magnetic resonance angiography for follow-up of coil embolization with the enterprise stent for cerebral aneurysms.

    Takayama K, Taoka T, Nakagawa H, Myouchin K, Wada T, Sakamoto M, Fukusumi A, Iwasaki S, Kurokawa S, Kichikawa K

    Journal of computer assisted tomography   Vol. 35 ( 5 ) page: 568-72   2011.9

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    DOI: 10.1097/RCT.0b013e31822bd498

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  93. White matter changes in dementia with Lewy bodies and Alzheimer's disease: a tractography-based study.

    Kiuchi K, Morikawa M, Taoka T, Kitamura S, Nagashima T, Makinodan M, Nakagawa K, Fukusumi M, Ikeshita K, Inoue M, Kichikawa K, Kishimoto T

    Journal of psychiatric research   Vol. 45 ( 8 ) page: 1095-100   2011.8

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    DOI: 10.1016/j.jpsychires.2011.01.011

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  94. Transient hyperintensity in the subthalamic nucleus and globus pallidus of newborns on T1-weighted images.

    Taoka T, Aida N, Ochi T, Takahashi Y, Akashi T, Miyasaka T, Iwamura A, Sakamoto M, Kichikawa K

    AJNR. American journal of neuroradiology   Vol. 32 ( 6 ) page: 1130-7   2011.6

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    DOI: 10.3174/ajnr.A2451

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  95. Characteristic neuroimaging in patients with tumefactive demyelinating lesions exceeding 30 mm.

    Kiriyama T, Kataoka H, Taoka T, Tonomura Y, Terashima M, Morikawa M, Tanizawa E, Kawahara M, Furiya Y, Sugie K, Kichikawa K, Ueno S

    Journal of neuroimaging : official journal of the American Society of Neuroimaging   Vol. 21 ( 2 ) page: e69-77   2011.4

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    DOI: 10.1111/j.1552-6569.2010.00502.x

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  96. Initial experience of carotid artery stenting using the Carotid WALLSTENT and FilterWire EZ in Japan.

    Takayama K, Taoka T, Nakagawa H, Myouchin K, Wada T, Miyasaka T, Sakamoto M, Fukusumi A, Iwasaki S, Kimura R, Kurokawa S, Kichikawa K

    Japanese journal of radiology   Vol. 29 ( 1 ) page: 51-8   2011.1

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    DOI: 10.1007/s11604-010-0518-x

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  97. Serial neuroimaging in tolosa-hunt syndrome with acute bilateral complete ophthalmoplegia.

    Sugie K, Morikawa M, Taoka T, Hirano M, Ueno S

    Journal of neuroimaging : official journal of the American Society of Neuroimaging   Vol. 21 ( 1 ) page: 79-82   2011.1

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    DOI: 10.1111/j.1552-6569.2009.00381.x

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  98. Hyperintense dentate nucleus on unenhanced T1-weighted MR images is associated with a history of brain irradiation.

    Kasahara S, Miki Y, Kanagaki M, Yamamoto A, Mori N, Sawada T, Taoka T, Okada T, Togashi K

    Radiology   Vol. 258 ( 1 ) page: 222-8   2011.1

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    DOI: 10.1148/radiol.10100508

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  99. Discrepancy in T1 and T2 shortening of the globus pallidus in hepatic insufficiency: evaluation by susceptibility-weighted imaging.

    Ochi T, Taoka T, Akashi T, Sakamoto M, Miyasaka T, Wada T, Nakagawa H, Takehana K, Tatsuno K, Kichikawa K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 10 ( 2 ) page: 79-83   2011

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  100. Brain surface motion imaging to predict adhesions between meningiomas and the brain surface.

    Taoka T, Yamada S, Yamatani Y, Akashi T, Miyasaka T, Emura T, Nakase H, Kichikawa K

    Neuroradiology   Vol. 52 ( 11 ) page: 1003-10   2010.11

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    DOI: 10.1007/s00234-010-0671-z

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  101. Biphasic paraneoplastic brainstem encephalitis associated with anti-Ri antibody.

    Tesseki K, Kataoka H, Terashima M, Kawahara M, Taoka T, Tanaka K, Ueno S

    Journal of neuro-oncology   Vol. 100 ( 1 ) page: 141-3   2010.10

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    DOI: 10.1007/s11060-010-0135-7

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  102. Anatomical evaluation of the dural sinuses in the region of the torcular herophili using three dimensional CT venography.

    Fukusumi A, Okudera T, Takahashi S, Taoka T, Sakamoto M, Nakagawa H, Takayama K, Kichikawa K, Iwasaki S

    Academic radiology   Vol. 17 ( 9 ) page: 1103-11   2010.9

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    DOI: 10.1016/j.acra.2010.04.020

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  103. Hepatocellular carcinoma of the iliac bone with unknown primary.

    Takahama J, Taoka T, Marugami N, Anai H, Kitano S, Kichikawa K, Nonomura A

    Skeletal radiology   Vol. 39 ( 7 ) page: 721-4   2010.7

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    DOI: 10.1007/s00256-010-0891-7

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  104. Artery-to-artery embolism with a mobile mural thrombus due to rotational vertebral artery occlusion.

    Saito K, Hirano M, Taoka T, Nakagawa H, Kitauchi T, Tanizawa E, Yoshida K, Sakurai Y, Tamura K, Nakase H, Yoshioka A, Sakaki T, Kichikawa K, Ueno S

    Journal of neuroimaging : official journal of the American Society of Neuroimaging   Vol. 20 ( 3 ) page: 284-6   2010.7

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    DOI: 10.1111/j.1552-6569.2008.00309.x

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  105. Magnetic resonance plaque imaging to predict the occurrence of the slow-flow phenomenon in carotid artery stenting procedures.

    Sakamoto M, Taoka T, Nakagawa H, Takayama K, Wada T, Myouchin K, Akashi T, Miyasaka T, Fukusumi A, Iwasaki S, Kichikawa K

    Neuroradiology   Vol. 52 ( 4 ) page: 275-83   2010.4

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    DOI: 10.1007/s00234-009-0623-7

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  106. Uncinate fasciculus-correlated cognition in Alzheimer's disease: a diffusion tensor imaging study by tractography.

    Morikawa M, Kiuchi K, Taoka T, Nagauchi K, Kichikawa K, Kishimoto T

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society   Vol. 10 ( 1 ) page: 15-20   2010.3

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    DOI: 10.1111/j.1479-8301.2010.00312.x

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  107. Magnetic resonance angiography with midsagittal saturation for the assessment of blood flow from superficial temporal artery-to-middle cerebral artery bypass.

    Akashi T, Taoka T, Miyasaka T, Myochin K, Sakamoto M, Takayama K, Nakagawa H, Kichikawa K

    Journal of computer assisted tomography   Vol. 34 ( 1 ) page: 89-92   2010.1

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    DOI: 10.1097/RCT.0b013e3181ac914e

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  108. Juvenile Bow Hunter's Stroke without Hemodynamic Changes.

    Saito K, Hirano M, Taoka T, Nakagawa H, Kitauchi T, Ikeda M, Tanizawa E, Kichikawa K, Ueno S

    Clinical medicine insights. Case reports   Vol. 3   page: 1-4   2010

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  109. Carotid artery stenosis with intraluminal thrombus discovered during carotid artery stenting.

    Takayama K, Taoka T, Nakagawa H, Miyasaka T, Myouchin K, Wada T, Sakamoto M, Akashi T, Kichikawa K

    Japanese journal of radiology   Vol. 27 ( 9 ) page: 367-70   2009.11

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    DOI: 10.1007/s11604-009-0348-x

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  110. Superior clinical impact of FDG-PET compared to MRI for the follow-up of a patient with sacral lymphoma.

    Yamamoto Y, Taoka T, Nakamine H

    Journal of clinical and experimental hematopathology : JCEH   Vol. 49 ( 2 ) page: 109-15   2009.11

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  111. Prototype of foot-controlled image-scrolling device for the picture archiving and communication system display interface.

    Taoka T, Takahama J, Nishimoto Y, Miura S, Takewa M, Kubota Y, Kichikawa K

    Journal of computer assisted tomography   Vol. 33 ( 6 ) page: 978-80   2009.11

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    DOI: 10.1097/RCT.0b013e31819d98da

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  112. Fractional anisotropy--threshold dependence in tract-based diffusion tensor analysis: evaluation of the uncinate fasciculus in Alzheimer disease.

    Taoka T, Morikawa M, Akashi T, Miyasaka T, Nakagawa H, Kiuchi K, Kishimoto T, Kichikawa K

    AJNR. American journal of neuroradiology   Vol. 30 ( 9 ) page: 1700-3   2009.10

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    DOI: 10.3174/ajnr.A1698

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  113. Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer's disease: a diffusion tensor tractography study.

    Kiuchi K, Morikawa M, Taoka T, Nagashima T, Yamauchi T, Makinodan M, Norimoto K, Hashimoto K, Kosaka J, Inoue Y, Inoue M, Kichikawa K, Kishimoto T

    Brain research   Vol. 1287   page: 184-91   2009.9

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    DOI: 10.1016/j.brainres.2009.06.052

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  114. Early contrast-enhanced magnetic resonance imaging with fluid-attenuated inversion recovery in multiple sclerosis.

    Kataoka H, Taoka T, Ueno S

    Journal of neuroimaging : official journal of the American Society of Neuroimaging   Vol. 19 ( 3 ) page: 246-9   2009.7

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    DOI: 10.1111/j.1552-6569.2008.00315.x

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  115. Reduced N-acetylaspartate in the basal ganglia of a patient with anti-NMDA receptor encephalitis.

    Kataoka H, Dalmau J, Taoka T, Ueno S

    Movement disorders : official journal of the Movement Disorder Society   Vol. 24 ( 5 ) page: 784-6   2009.4

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    DOI: 10.1002/mds.22167

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  116. "Sukeroku sign" and "dent internal-capsule sign"--identification guide for targeting the subthalamic nucleus for placement of deep brain stimulation electrodes.

    Taoka T, Hirabayashi H, Nakagawa H, Sakamoto M, Kitano S, Takahama J, Marugami N, Takayama K, Akashi T, Miyasaka T, Iwasaki S, Kurita N, Sakaki T, Kichikawa K

    Neuroradiology   Vol. 51 ( 1 ) page: 11-6   2009.1

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    DOI: 10.1007/s00234-008-0451-1

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  117. Prominent signal intensity of T1/T2 prolongation in subcortical white matter of the anterior temporal region on conventional screening MRI of late preterm infants with normal development.

    Wuttikul C, Taoka T, Akashi T, Nakagawa H, Miyasaka T, Sakamoto M, Takayama K, Wada T, Kitano S, Takahama J, Marugami N, Kichikawa K

    Magnetic resonance imaging   Vol. 26 ( 10 ) page: 1374-80   2008.12

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    DOI: 10.1016/j.mri.2008.04.014

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  118. Discriminating between silent cerebral infarction and deep white matter hyperintensity using combinations of three types of magnetic resonance images: a multicenter observer performance study.

    Sasaki M, Hirai T, Taoka T, Higano S, Wakabayashi C, Matsusue E, Ida M

    Neuroradiology   Vol. 50 ( 9 ) page: 753-8   2008.9

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    DOI: 10.1007/s00234-008-0406-6

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  119. Diffusion tensor tractography of the Meyer loop in cases of temporal lobe resection for temporal lobe epilepsy: correlation between postsurgical visual field defect and anterior limit of Meyer loop on tractography.

    Taoka T, Sakamoto M, Nakagawa H, Nakase H, Iwasaki S, Takayama K, Taoka K, Hoshida T, Sakaki T, Kichikawa K

    AJNR. American journal of neuroradiology   Vol. 29 ( 7 ) page: 1329-34   2008.8

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    DOI: 10.3174/ajnr.A1101

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  120. Initial experience of using the filter protection device during carotid artery stenting in Japan.

    Takayama K, Nakagawa H, Iwasaki S, Taoka T, Miyasaka T, Myouchin K, Wada T, Sakamoto M, Fukusumi A, Nakagawa I, Kurokawa S, Kichikawa K

    Radiation medicine   Vol. 26 ( 6 ) page: 348-54   2008.7

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    DOI: 10.1007/s11604-008-0239-6

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  121. Multiple cerebral aneurysms associated with Takayasu arteritis successfully treated with coil embolization.

    Takayama K, Nakagawa H, Iwasaki S, Taoka T, Myouchin K, Wada T, Sakamoto M, Fukusumi A, Kurokawa S, Kichikawa K

    Radiation medicine   Vol. 26 ( 1 ) page: 33-8   2008.1

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    DOI: 10.1007/s11604-007-0184-9

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  122. Cerebral Sinus and Venous Thrombosis Associated with von Willebrand Factor, Independently of Factor VIII.

    Terashima M, Kataoka H, Horikawa H, Nakagawa H, Taoka T, Matsumoto M, Saito K, Kichikawa K, Ueno S

    Clinical medicine. Case reports   Vol. 1   page: 29-32   2008

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  123. Signal changes of superior cerebellar peduncle on fluid-attenuated inversion recovery in progressive supranuclear palsy.

    Kataoka H, Tonomura Y, Taoka T, Ueno S

    Parkinsonism & related disorders   Vol. 14 ( 1 ) page: 63-5   2008

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    DOI: 10.1016/j.parkreldis.2007.03.001

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  124. A case of infantile Alexander disease diagnosed by magnetic resonance imaging and genetic analysis.

    Sakakibara T, Takahashi Y, Fukuda K, Inoue T, Kurosawa T, Nishikubo T, Shima M, Taoka T, Aida N, Tsujino S, Kanazawa N, Yoshioka A

    Brain & development   Vol. 29 ( 8 ) page: 525-8   2007.9

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    DOI: 10.1016/j.braindev.2007.02.002

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  125. Diffusivity and diffusion anisotropy of cerebellar peduncles in cases of spinocerebellar degenerative disease.

    Taoka T, Kin T, Nakagawa H, Hirano M, Sakamoto M, Wada T, Takayama K, Wuttikul C, Iwasaki S, Ueno S, Kichikawa K

    NeuroImage   Vol. 37 ( 2 ) page: 387-93   2007.8

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    DOI: 10.1016/j.neuroimage.2007.05.028

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  126. Cerebral hemorrhage with angiographic extravasation immediately after carotid artery stenting.

    Takayama K, Nakagawa H, Iwasaki S, Taoka T, Wada T, Myouchin K, Sakamoto M, Fukusumi A, Kichikawa K

    Radiation medicine   Vol. 25 ( 7 ) page: 359-63   2007.8

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    DOI: 10.1007/s11604-007-0147-1

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  127. Parasagittal Arachnoid Markings on the Inner Skull on Three-Dimensional CT: Relation between Hydrocephalus and Arachnoid Granules.

    Taoka T, Ida Y, Nakagawa H, Iwasaki S, Sakamoto M, Fukusumi A, Takayama K, Wada T, Myochin K, Wuttikul C, Kichikawa K

    The neuroradiology journal   Vol. 20 ( 3 ) page: 259-64   2007.6

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  128. Successful percutaneous transluminal angioplasty and stenting for symptomatic intracranial vertebral artery stenosis using intravascular ultrasound virtual histology.

    Takayama K, Taoka T, Nakagawa H, Myouchin K, Wada T, Sakamoto M, Fukusumi A, Iwasaki S, Kurokawa S, Kichikawa K

    Radiation medicine   Vol. 25 ( 5 ) page: 243-6   2007.6

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    DOI: 10.1007/s11604-007-0127-5

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  129. Treatable fluctuating Parkinsonism and dementia in a patient with a dural arteriovenous fistula.

    Kajitani M, Yagura H, Kawahara M, Hirano M, Ueno S, Fujimoto K, Sakaki T, Taoka T, Nakagawa H, Kichikawa K

    Movement disorders : official journal of the Movement Disorder Society   Vol. 22 ( 3 ) page: 437-9   2007.2

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    DOI: 10.1002/mds.21194

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  130. Extensive neuroimaging of a transient lesion in the splenium of the corpus callosum.

    Shimizu H, Kataoka H, Yagura H, Hirano M, Taoka T, Ueno S

    European journal of neurology : the official journal of the European Federation of Neurological Societies   Vol. 14 ( 1 ) page: e37-9   2007.1

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    DOI: 10.1111/j.1468-1331.2006.01504.x

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  131. Displacement of the facial nerve course by vestibular schwannoma: preoperative visualization using diffusion tensor tractography.

    Taoka T, Hirabayashi H, Nakagawa H, Sakamoto M, Myochin K, Hirohashi S, Iwasaki S, Sakaki T, Kichikawa K

    Journal of magnetic resonance imaging : JMRI   Vol. 24 ( 5 ) page: 1005-10   2006.11

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    DOI: 10.1002/jmri.20725

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  132. Global and region-specific analyses of apparent diffusion coefficient in dentatorubral-pallidoluysian atrophy.

    Kin T, Hirano M, Taoka T, Furiya Y, Kataoka H, Kichikawa K, Ueno S

    AJNR. American journal of neuroradiology   Vol. 27 ( 7 ) page: 1463-6   2006.8

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  133. Evaluation of arteriosclerotic changes in the intracranial carotid artery using the calcium score obtained on plain cranial computed tomography scan: Correlation with angiographic changes and clinical outcome.

    Taoka T, Iwasaki S, Nakagawa H, Sakamoto M, Fukusumi A, Takayama K, Wada T, Myochin K, Hirohashi S, Kichikawa K

    Journal of computer assisted tomography   Vol. 30 ( 4 ) page: 624-8   2006.7

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  134. White matter T2 hyperintensity development and clinical deterioration after status epilepticus in a patient with dentatorubral-pallidoluysian atrophy.

    Takamure M, Hirano M, Taoka T, Ueno S

    Clinical neurology and neurosurgery   Vol. 108 ( 5 ) page: 482-5   2006.7

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    DOI: 10.1016/j.clineuro.2005.01.011

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  135. Serial therapy-induced changes in tumor shape in cervical cancer and their impact on assessing tumor volume and treatment response.

    Mayr NA, Yuh WT, Taoka T, Wang JZ, Wu DH, Montebello JF, Meeks SL, Paulino AC, Magnotta VA, Adli M, Sorosky JI, Knopp MV, Buatti JM

    AJR. American journal of roentgenology   Vol. 187 ( 1 ) page: 65-72   2006.7

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    DOI: 10.2214/AJR.05.0039

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  136. Pituitary stalk compression by the dorsum sellae: possible cause for late childhood onset growth disorders.

    Taoka T, Iwasaki S, Okamoto S, Sakamoto M, Nakagawa H, Otake S, Fujioka M, Hirohashi S, Kichikawa K

    Magnetic resonance imaging   Vol. 24 ( 5 ) page: 651-6   2006.6

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    DOI: 10.1016/j.mri.2005.12.015

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  137. Diffusion anisotropy and diffusivity of white matter tracts within the temporal stem in Alzheimer disease: evaluation of the "tract of interest" by diffusion tensor tractography.

    Taoka T, Iwasaki S, Sakamoto M, Nakagawa H, Fukusumi A, Myochin K, Hirohashi S, Hoshida T, Kichikawa K

    AJNR. American journal of neuroradiology   Vol. 27 ( 5 ) page: 1040-5   2006.5

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  138. Diffusion tensor imaging in cases with visual field defect after anterior temporal lobectomy.

    Taoka T, Sakamoto M, Iwasaki S, Nakagawa H, Fukusumi A, Hirohashi S, Taoka K, Kichikawa K, Hoshida T, Sakaki T

    AJNR. American journal of neuroradiology   Vol. 26 ( 4 ) page: 797-803   2005.4

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  139. Evaluation of extraocular muscles using dynamic contrast enhanced MRI in patients with chronic thyroid orbitopathy.

    Taoka T, Sakamoto M, Nakagawa H, Fukusumi A, Iwasaki S, Taoka K, Kichikawa K

    Journal of computer assisted tomography   Vol. 29 ( 1 ) page: 115-20   2005.1

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  140. Proton MR spectroscopy of adult-onset dentatorubral-pallidoluysian atrophy.

    Kin T, Hirano M, Taoka T, Takamure M, Furiya Y, Kichikawa K, Ueno S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 4 ( 3 ) page: 123-7   2005

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  141. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion.

    Tada H, Takanashi J, Barkovich AJ, Oba H, Maeda M, Tsukahara H, Suzuki M, Yamamoto T, Shimono T, Ichiyama T, Taoka T, Sohma O, Yoshikawa H, Kohno Y

    Neurology   Vol. 63 ( 10 ) page: 1854-8   2004.11

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  142. Paradoxical parasellar high signals resembling shunt diseases on routine 3D time-of-flight MR angiography of the brain: mechanism for the signals and differential diagnosis from shunt diseases.

    Sakamoto M, Taoka T, Iwasaki S, Nakagawa H, Fukusumi A, Takayama K, Wada T, Kichikawa K

    Magnetic resonance imaging   Vol. 22 ( 9 ) page: 1289-93   2004.11

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    DOI: 10.1016/j.mri.2004.08.004

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  143. Retinotopy with coordinates of lateral occipital cortex in humans.

    Kaido T, Hoshida T, Taoka T, Sakaki T

    Journal of neurosurgery   Vol. 101 ( 1 ) page: 114-8   2004.7

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    DOI: 10.3171/jns.2004.101.1.0114

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  144. Distinguishing between anterior cerebral artery and middle cerebral artery perfusion by color-coded perfusion direction mapping with arterial spin labeling.

    Taoka T, Iwasaki S, Nakagawa H, Fukusumi A, Hirohashi S, Sakamoto M, Kichikawa K, Murata K

    AJNR. American journal of neuroradiology   Vol. 25 ( 2 ) page: 248-51   2004.2

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  145. Signal characteristics of FLAIR related to water content: comparison with conventional spin echo imaging in infarcted rat brain.

    Taoka T, Fujioka M, Matsuo Y, Notoya M, Iwasaki S, Fukusumi A, Nakagawa H, Sakamoto M, Kichikawa K, Ohishi H

    Magnetic resonance imaging   Vol. 22 ( 2 ) page: 221-7   2004.2

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    DOI: 10.1016/j.mri.2003.09.004

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  146. Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration.

    Annals of neurology   Vol. 54 ( 6 ) page: 732-47   2003.12

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    DOI: 10.1002/ana.10751

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  147. Vasogenic edema and VEGF expression in a rat two-vein occlusion model.

    Kimura R, Nakase H, Sakaki T, Taoka T, Tsuji T

    Acta neurochirurgica. Supplement   Vol. 86   page: 213-7   2003

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  148. [Evaluation of appearance with high-speed CE-3dMRDSA in brain].

    Doi T, Nogi A, Taoka T, Hirohashi S

    Nihon Hoshasen Gijutsu Gakkai zasshi   Vol. 58 ( 12 ) page: 1615-21   2002.12

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  149. Method and timing of tumor volume measurement for outcome prediction in cervical cancer using magnetic resonance imaging.

    Mayr NA, Taoka T, Yuh WT, Denning LM, Zhen WK, Paulino AC, Gaston RC, Sorosky JI, Meeks SL, Walker JL, Mannel RS, Buatti JM

    International journal of radiation oncology, biology, physics   Vol. 52 ( 1 ) page: 14-22   2002.1

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  150. Palmaz stent deployment for subclavian and brachiocephalic arterial occlusive disease. Factors predictive of restenosis.

    Nakagawa H, Kichikawa K, Takayama K, Sakamoto M, Wada T, Taoka T, Fukusumi A, Iwasaki S, Uchida H, Sakaki T

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences   Vol. 7 ( Suppl 1 ) page: 49-52   2001.12

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  151. Detection of early venous filling in gliomas on MRI: preliminary study by 2D time-resolved dynamic contrast-enhanced MR angiography with echo-sharing technique.

    Sakamoto M, Taoka T, Iwasaki S, Fukusumi A, Nakagawa H, Hirohashi S, Takayama K, Wada T, Kichikawa K, Uchida H, Ohishi H, Murata K, Okamoto J

    Magnetic resonance imaging   Vol. 19 ( 9 ) page: 1193-201   2001.11

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  152. Factors influencing visualization of vertebral metastases on MR imaging versus bone scintigraphy.

    Taoka T, Mayr NA, Lee HJ, Yuh WT, Simonson TM, Rezai K, Berbaum KS

    AJR. American journal of roentgenology   Vol. 176 ( 6 ) page: 1525-30   2001.6

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    DOI: 10.2214/ajr.176.6.1761525

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  153. Sulcal hyperintensity on fluid-attenuated inversion recovery mr images in patients without apparent cerebrospinal fluid abnormality.

    Taoka T, Yuh WT, White ML, Quets JP, Maley JE, Ueda T

    AJR. American journal of roentgenology   Vol. 176 ( 2 ) page: 519-24   2001.2

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    DOI: 10.2214/ajr.176.2.1760519

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  154. MR imaging of pituitary morphology in idiopathic intracranial hypertension.

    Yuh WT, Zhu M, Taoka T, Quets JP, Maley JE, Muhonen MG, Schuster ME, Kardon RH

    Journal of magnetic resonance imaging : JMRI   Vol. 12 ( 6 ) page: 808-13   2000.12

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  155. Magnetic resonance imaging in the assessment of radiation response in cervical cancer: regarding Hatano K et al. IJROBP 1999; 45:399-344.

    Mayr NA, Taoka T, Yuh WT, Zhen WK, Paulino AC, Sorosky JI, Buatti JM

    International journal of radiation oncology, biology, physics   Vol. 48 ( 3 ) page: 910-2   2000.10

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  156. Functional magnetic resonance imaging using iron oxide particles in characterizing head and neck adenopathy.

    Hoffman HT, Quets J, Toshiaki T, Funk GF, McCulloch TM, Graham SM, Robinson RA, Schuster ME, Yuh WT

    The Laryngoscope   Vol. 110 ( 9 ) page: 1425-30   2000.9

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    DOI: 10.1097/00005537-200009000-00002

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  157. Enhancement pattern of normal extraocular muscles in dynamic contrast-enhanced MR imaging with fat suppression.

    Taoka T, Iwasaki S, Uchida H, Fukusumi A, Kichikawa K, Nakagawa H, Takayama K, Sakamoto M, Ohishi H

    Acta radiologica (Stockholm, Sweden : 1987)   Vol. 41 ( 3 ) page: 211-6   2000.5

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  158. Hippocampal damage in the human brain after cardiac arrest.

    Fujioka M, Nishio K, Miyamoto S, Hiramatsu KI, Sakaki T, Okuchi K, Taoka T, Fujioka S

    Cerebrovascular diseases (Basel, Switzerland)   Vol. 10 ( 1 ) page: 2-7   2000.1

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    DOI: 16018

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  159. Imaging helps identify who benefits from stroke intervention.

    Yuh WT, Taoka T, Ueda T, Chaloupka JC

    Diagnostic imaging   Vol. 21 ( 12 ) page: 77-82   1999.12

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  160. Current and future imaging of acute cerebral ischemia: assessment of tissue viability by perfusion imaging.

    Ueda T, Yuh WT, Maley JE, Otake S, Quets JP, Taoka T, Hahn PY, White ML

    Journal of computer assisted tomography   Vol. 23 Suppl 1   page: S3-7   1999.11

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  161. The need for objective assessment of the new imaging techniques and understanding the expanding roles of stroke imaging.

    Yuh WT, Ueda T, White M, Schuster ME, Taoka T

    AJNR. American journal of neuroradiology   Vol. 20 ( 10 ) page: 1779-84   1999.11

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  162. Clinical application of perfusion and diffusion MR imaging in acute ischemic stroke.

    Ueda T, Yuh WT, Taoka T

    Journal of magnetic resonance imaging : JMRI   Vol. 10 ( 3 ) page: 305-9   1999.9

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  163. Secondary change in the substantia nigra induced by incomplete infarct and minor hemorrhage in the basal ganglia due to traumatic middle cerebral arterial dissection.

    Fujioka M, Maeda Y, Okuchi K, Kagoshima T, Taoka T

    Stroke; a journal of cerebral circulation   Vol. 30 ( 9 ) page: 1975-7   1999.9

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  164. Novel brain ischemic change on MRI. Delayed ischemic hyperintensity on T1-weighted images and selective neuronal death in the caudoputamen of rats after brief focal ischemia.

    Fujioka M, Taoka T, Matsuo Y, Hiramatsu KI, Sakaki T

    Stroke; a journal of cerebral circulation   Vol. 30 ( 5 ) page: 1043-6   1999.5

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  165. Age correlation of the time lag in signal change on EPI-fMRI.

    Taoka T, Iwasaki S, Uchida H, Fukusumi A, Nakagawa H, Kichikawa K, Takayama K, Yoshioka T, Takewa M, Ohishi H

    Journal of computer assisted tomography   Vol. 22 ( 4 ) page: 514-7   1998.7

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  166. Normal myelination of anatomic nerve fiber bundles: MR analysis.

    Nakagawa H, Iwasaki S, Kichikawa K, Fukusumi A, Taoka T, Ohishi H, Uchida H

    AJNR. American journal of neuroradiology   Vol. 19 ( 6 ) page: 1129-36   1998.6

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  167. Long-term palliative treatment of hepatocellular carcinoma extending into the portal vein and bile duct by chemoembolization and metallic stenting.

    Yoshioka T, Uchida H, Kitano S, Makutani S, Maeda M, Taoka T, Ohishi H

    Cardiovascular and interventional radiology   Vol. 20 ( 5 ) page: 390-3   1997.9

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  168. Cine-magnetic resonance imaging evaluation of communication between middle cranial fossa arachnoid cysts and cisterns.

    Eguchi T, Taoka T, Nikaido Y, Shiomi K, Fujimoto T, Otsuka H, Takeuchi H

    Neurologia medico-chirurgica   Vol. 36 ( 6 ) page: 353-7   1996.6

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  169. Fast fluid-attenuated inversion recovery (FAST-FLAIR) of ischemic lesions in the brain: comparison with T2-weighted turbo SE.

    Taoka T, Iwasaki S, Nakagawa H, Fukusumi A, Kitano S, Yoshioka T, Ohishi H, Uchida H, Nakanishi S, Hirai A

    Radiation medicine   Vol. 14 ( 3 ) page: 127-31   1996.5

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▼display all

Books 4

  1. 頭部画像診断の勘ドコロNEO

    田岡 俊昭( Role: Joint author)

    メジカルビュー社  2021  ( ISBN:9784758316132

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  2. Neuroimaging Diagnosis for Alzheimer’s Disease and Other Dementias

    Toshiaki Taoka( Role: Contributor ,  Diffusion Tensor Imaging in Dementia)

    Springer Japan  2017 

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    Responsible for pages:117-128   Language:English Book type:Scholarly book

  3. "Movement Disorders" in "Geriatric Imaging"

    Guglielmi G, Peh, WCG.; Guermazi, A eds( Role: Sole author)

    Springer-Verlag  2013 

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    Language:English

  4. Chapter 11:"Imaging and tissue characterization of atherosclerotic carotid plaque using MR imaging" in "Neurovascular Imaging"

    Takahashi, S Ed( Role: Sole author)

    Springer-Verlag  2010 

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    Language:English

MISC 3

  1. Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model Reviewed

    Taoka T, Fujioka M, Kashiwagi Y, Obata A, Rokugawa T, Hori M, Masutani Y, Aoki S, Naganawa S, Abe K

    J Stroke Cerebrovasc Dis.     2015.12

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    DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.028.

  2. Characteristic MRI Findings of upper Limb Muscle Involvement in Myotonic Dystrophy Type 1 Reviewed

    Sugie K, Sugie M, Taoka T, Tonomura Y, Kumazawa A, Izumi T, Kichikawa K, Ueno S

    PLoS One.   Vol. 10 ( 4 ) page: e0125051   2015.4

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    DOI: 10.1371/journal.pone.0125051.

  3. Characteristic MRI Findings of upper Limb Muscle Involvement in Myotonic Dystrophy Type 1

    Kazuma Sugie, Miho Sugie, Toshio Taoka, Yasuyo Tonomura, Aya Kumazawa, Tesseki Izumi, Kimihiko Kichikawa, Satoshi Ueno

    PLOS ONE   Vol. 10 ( 4 ) page: e0125051   2015.4

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:PUBLIC LIBRARY SCIENCE  

    The objective of our study was to evaluate the relation between muscle MRI findings and upper limb weakness with grip myotonia in patients with myotonic dystrophy type 1 (DM1). Seventeen patients with DM1 were evaluated by manual muscle strength testing and muscle MRI of the upper limbs. Many DM1 patients presenting with decreased grasping power frequently showed high intensity signals in the flexor digitorum profundus (FDP) muscles on T1-weighted imaging. Patients presenting with upper limb weakness frequently also showed high intensity signals in the flexor pollicis longus, abductor pollicis longus, and extensor pollicis muscles. Disturbances of the distal muscles of the upper limbs were predominant in all DM1 patients. Some DM1 patients with a prolonged disease duration showed involvement of not only distal muscles but also proximal muscles in the upper limbs. Muscle involvement of the upper limbs on MRI strongly correlated positively with the disease duration or the numbers of CTG repeats. To our knowledge, this is the first study to provide a detailed description of the distribution and severity of affected muscles of the upper limbs on MRI in patients with DM1. We conclude that muscle MRI findings are very useful for identifying affected muscles and predicting the risk of muscle weakness in the upper limbs of DM1 patients.

    DOI: 10.1371/journal.pone.0125051

    Web of Science

    PubMed

KAKENHI (Grants-in-Aid for Scientific Research) 12

  1. In vivo investigation of neuroinflammation of AD with PET molecular imaging

    Grant number:19H03590  2019.4 - 2022.3

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    Authorship:Coinvestigator(s) 

  2. 血液脳関門透過性の再定義に向けて

    Grant number:18K19510  2018.6 - 2021.3

    挑戦的研究(萌芽)

    長縄 慎二

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    今回の研究課題の目的である ”血液脳関門透過性の再定義に向けて” を進めるために、近年、我々が開発した液体中の極微量のガドリニウム造影剤への感度をさらに高めた新規パルスシーケンスの臨床応用を進めてきた。
    パルスシークエンスパラメーターの最適化として、繰り返し時間の延長と反転時間の最適化、フリップアングルの増加などを施行し、それらにより、従来よりも半分の時間で、同等のコントラストノイズ比を達成するimproved-HYDROPS(i-HYDROPS)法とi-HYDROPSの技術を応用しつつ、さらに造影後のParadoxycal signal decreaseを防ぐための3D-real IR法も用いて、臨床例で脳脊髄液と迷路リンパ液の造影効果を検討してきている。
    臨床経験の増加とともに、ガドリニウム造影剤静注後4時間にて、脳表の皮質静脈から脳脊髄液へのガドリニウム造影剤の漏れがLabbe静脈周囲や頭頂部皮質静脈周囲に多くみられること、そしてその漏出の程度は、37歳以降に急速に目立つようになり、年齢と相関することを前年度、世界で初めて見出した。さらに今年度は、症例を追加して、例外は一定数あるもののROC解析を行うと、37.3歳が漏出のカットオフ値として適切であることを論文化した(Magn Reson Med Sci. 2020 Feb 6. doi: 10.2463/mrms.mp.2019-0182. )。
    さらにGlymphatic systemの評価のためにT1, T2などの磁気共鳴画像パラメーターを高速に定量するMR fingerprintingを用いた静注後のガドリニウム造影剤の小脳内での分布についての臨床データの収集を行って論文化を果たした(Magn Reson Med Sci, accepted)。
    新規のパルスシーケンス開発(i-HYDROPS, i-3D-real IR)とその利用がうまく進んだため、予想以上に成果を上げることが出来た。液体中の低濃度ガドリニウム造影剤の検出感度に優れたパルスシーケンスを初期より開発し、利用できたことにより、データのばらつきは小さくなった。当初より目標としてきた、脳実質の高精度の定量技術(MR fingerprinting)によって、脳実質におけるガドリニウム造影剤の分布も検討ができている。
    特に静注ガドリニウム造影剤による内耳や脳の老廃物排泄機構と血液脳関門の解析に有用となるガドリニウム造影剤が漏出する部位について、我々が以前発見した内耳神経末端や迷路、視神経周囲、三叉神経周囲、前眼房、脳室周囲器官(Circumventricular organ; CVO)のなかの終板脈管器官(Organum vasculosum of Lamina terminalis; OVLT)に加えて、Labbe静脈や頭頂部の皮質静脈などの様々な皮質静脈から脳脊髄液への漏れを我々の方法で示せたことに加えて、漏れの年齢依存性の詳細を明らかにできたことは意義が極めて大きい。
    今年度までで上記を達成できたので、今後は臨床例でのガドリニウム造影剤の様々な生理的、病理的タイミングでの静脈内投与における定量的な撮像データを蓄積することが重要となる。さらには当初は予備的な課題と考えていた睡眠との関連も検討する余地が出てきた。このように様々な角度から進展しており概ね順調と判断する。脳脊髄液についての詳細も、脳槽や脳室の各部位におけるガドリニウム造影剤の分布の違いや、部位ごとの年令による影響も日本磁気共鳴医学会で2019年、熊本で発表できた。これについても論文化を進めている。
    我々が見出すことができた静注後のガドリニウム造影剤が脳脊髄液にリークするポイントが多数あることは上記でも述べたが、そのリークする程度と年齢の相関についても昨年度の初期発表に続いて、より詳細はカットオフ値を報告することができた。
    今後は、さらに症例を増やして性別、疾患状態、睡眠や水負荷などの生理的状態などと漏れの関係を複合的に検討することにより、血液脳脊髄液関門の状態をダイナミックに評価することができる。それらを評価することで、内耳や脳の老廃物排泄機構に影響を与える諸因子を考察することができ、老廃物排泄機構の実態解明にさらに迫ることができる。血液脳脊髄液関門の状態という医学全体に広がる重要事項の理解に革新を起こすことが本課題の目的であるので、脳実質用の高精度定量技術のMR fingerprintingも辞書データを脳脊髄液用に変更することも開発が終了しており、さらには実質と脳脊髄液を同時に評価する撮像技術の臨床応用も進める予定である。
    Glymphatic systemは睡眠時に活発に活動することが知られており、今後、さらにヒトで、ガドリニウム造影剤を静注投与するタイミングを睡眠時無呼吸症候群に対する治療の前と後に設定することで血液迷路関門の状態のダイナミックな変化を観察することも計画している。
    ヒトにおいても健常者でのガドリニウム造影剤投与を新たに開発したMR fingerprintingと我々の高感度新規パルスシーケンスを用いて行って初期論文も出版したが、さらに症例を増やしてより詳細な検討をすることが近々の目標である。
    また造影剤を使用するまでもなく、血管周囲腔内に貯留している液体の成分の日内変動を観察することも試みる予定でデータは蓄積しつつある。ヒトにとって大きな問題である神経変性疾患の謎と薬学全体に影響する血液迷路関門の謎に複数の面からできるだけさらに迫るつもりである。

  3. Development of new dimensional clinical neuroimaging method based on the waste clearance system of inner ear

    Grant number:17H04259  2017.4 - 2020.3

    Naganawa Shinji

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    We have developed new MR pulse sequences that have extremely high sensitivity to low concentration gadolinium based contrast agent. Then we applied them to the patients with the suspicion of endolymphatic hydrops in the inner ear. We found and reported that the leakage of gadolinium to cerebrospinal fluid around cortical veins in the patients older than 37-years-old. As we accumulate many patients' data, we experienced some exceptional cases who shows leakage from younger period. Also we experienced the subjects without leakage in oldr subjects. We exnamined 190 cases, finally, we could find the cut-off value of 37.3-years-old from the receiver operating curve analysis. We have published this result on the journal "Magnetic Resonance in Medical Sciences". These results are gathering many attentions from neuroscience community as the objective biomaker of brain aging.

  4. Evaluation of glymphatic system in the human brain using diffusion MR images and application to Alzheimer's disease.

    Grant number:17K10397  2017.4 - 2020.3

    Taoka Toshiaki

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    In the current study, we hypothesized that diffusivity limited to the direction of perivascular space correlates with activity of the Glymphatic system. We developed a method called "diffusion tensor image analysis along the perivascular space (DTI-ALPS)" as a method to evaluate the movement of water molecules in deep white matter from diffusion tensor images. In this method, the diffusivity in the perivascular space in the white matter outside the lateral ventricle was evaluated using the ratio to the diffusivity in the orthogonal direction(ALPS index). In the evaluation of Alzheimer's disease cases, the ALPS index was significantly inversely correlated with the MMSE score. This suggests that the ALPS index may be an index that reflects the function of the Glymphatic system.

  5. depelopment of low invasive imaging evaluation for human glymphatic system

    Grant number:16K10312  2016.4 - 2020.3

    Kawai Hisashi

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    We were able to indicate the leakage of Gadolinium-based contrast agent (GBCA) into the subarachnoid space around the cortical veins with MRI obtained after intravenous injection of GBCA.And intravenously administered GBCA leaks into the subarachnoid space around the cortical veins in most patients over 37 years of age. However, it should be noted that it can be found occasionally in patients under 37 years of age.

  6. Neuroprotective effects of ADAMTS13 against delayed brain ischemia after subarachnoid hemorrhage

    Grant number:26462170  2014.4 - 2018.3

    Fujioka Masayuki

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    ADAMTS13 cleaves VWF and reduces its prothrombotic and proinflammatory functions. Thus, ADAMTS13 protects the brain against acute ischemia by ameliorating post-ischemic brain hypoperfusion and inflammation. We studied the effect of ADAMTS13 on delayed cerebral ischemia after aneurysmal SAH. We evaluated the mice SAH model with 7.0 Tesla MRI and histology. The effects of ADAMTS13 on delayed cerebral microthrombi, cerebral vasospasm, neuronal inflammation, and neuronal death in the cerebral cortex and hippocampus were analyzed over time after SAH by comparing the groups with and without ADAMTS13 administration. ADAMTS13 significantly reduced microthrombosis, neuroinflammation and degenerative neurons, and improved neurological performance in SAH models. Our study with ADAMTS13 knockout mice signified neuroprotective effects of ADAMTS13 in SAH models. ADAMTS13 could provide a novel therapeutic approach for delayed cerebral ischemia after SAH as well as for acute ischemic stroke.

  7. 非正規分布拡散画像(拡散尖度画像)によるアルツハイマー病の病期診断および予後予測

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  8. 非正規分布拡散画像(拡散尖度画像)によるアルツハイマー病の病期診断および予後予測

    2014.4 - 2017.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Competitive

  9. Non Gaussian diffusion images for Alzheimer's disease

    Grant number:26461834  2014.4 - 2017.3

    Toshiaki Taoka

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    Authorship:Principal investigator 

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    We analyzed cases of Alzheimer’s disease cases using Non-Gaussian diffusion images. The cases were also clinically evaluated including MMSE score and divided into Alzheimer’s disease group, mild cognitive impairment group and subjective cognitive impairment group. By using 3T MR imager, we acquired Non-Gaussian diffusion images and generated diffusion kurtosis images (DKI). DKI showed the decreased diffusion kurtosis in the uncinated fascicles in correlation with severity of the Alzheimer’s disease. That may indicate abnormality in the microstructure of the white matter in the uncinated fascicles which is a part of limbic system.

  10. 拡散テンソル線維路解析とサポートベクトルマシンによるアルツハイマー病の早期診断

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  11. 統合失調症患者におけるニューレグリン1機能の多角的解析

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(C)

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  12. アルツハイマー病での辺縁系回路の拡散テンソル異常―臨床症状・予後との関連―

    2008.4 - 2011.3

    科学研究費補助金  基盤研究(C)

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Teaching Experience (Off-campus) 1

  1. 2015.4 - 2016.3 Nara Medical University)