Updated on 2025/11/18

写真a

 
HASEBE Yuichi
 
Organization
Graduate School of Medicine Nagoya University-MENARD Collaborative Research Chair Industry-Academia Collaborative Chair Designated Lecturer
Title
Designated Lecturer

Degree 1

  1. 博士（生物資源科学） （ 2005.3   日本大学 ） 

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Papers 32

  1. Localization of collagen type 5 in the papillary dermis and its role in maintaining stem cell functions. Reviewed Open Access

    Hasebe Y, Hasegawa S, Date Y, Nakata S, Yagami A, Iwata Y, Sugiura K, Akamatsu H.

    Journal of Dermatological Science   Vol. 89 ( 2 ) page： 205 - 207   2018.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    Research Background
    Stem cells in the skin have a long history of investigation compared to those in other tissues. Indeed, culturing methods of artificial epidermis were already established, and application to regenerative therapy (e.g. those against severe burn) has been started. As for other deeper skin tissues than the epidermis, including the dermis, subcutaneous adipose, and hair follicles, regeneration mechanisms of each tissue remain largely unknown, although existence of stem cells was reported. To achieve generation of the skin tissue including these lower layers in vitro, it is necessary to conduct research further on the stem cells in the dermis, subcutaneous adipose, and hair follicles and answering questions one by one should lead to innovation of technologies in wound treatment, drug development, and skin health and cosmetics.
    We have been studying stem cells in the skin by isolating from skin tissues and culturing in vitro as well as generating 3D reconstructed epidermis, and showed the age-related changes and the role of stem cells in wound healing (Akamatsu et al., 2016; Iwata et al., 2017). In this study, we focused on the dermal stem cells, which had been less examined compared to other stem cells in the skin, to understand the maintenance and generation mechanisms of the dermis.

    Research Results
    The dermis is constituted of the upper papillary and lower reticular dermis. The papillary dermis has thin collagen fibers and is a sparse and soft tissue, on the other hand, the reticular dermis is composed of dense and solid tissue made up of thicker collagen fibers. We focused on these histological differences between the papillary and reticular dermis, and examined in detail cells and characteristics of collagen fibers in each layer. It was found that stem cells (CD271-positive cells) were mostly localized in the papillary layer. In addition, collagen type 5 was found to be highly expressed around the dermal stem cells, indicating that the dermal stem cells were localized in a collagen type 5-rich area of the papillary dermis.
    Collagen type 5 was known to function in angiogenesis (Hering et al., 1983) and wound healing (Cuttle et al., 2005), but its effect on stem cells had not been studied. To understand the effect of collagen type 5 and the dermal stem cells, we cultured dermal stem cells with or without collagen type 5, and found that the stem cells required collagen type 5 to maintain their number, indicating that collagen type 5 plays an important role in maintaining an undifferentiated state of the dermal stem cells.
    The skin is exposed to various kinds of external stress, such as the ultraviolet and physical stimuli, and therefore required to have a high potential of tissue regeneration. In the dermis, the stem cells, which are required for regeneration, were found to be localized in the papillary dermis, and the papillary dermis is thought to be the site of regeneration where new dermal cells and constituents are supplied. It was also suggested that collagen type 5 functions to maintain the dermal stem cells.

    DOI： 10.1016/j.jdermsci.2017.10.005

    Open Access

    Web of Science

    PubMed

  2. Analysis of cell characterization using cell surface markers in the dermis. Reviewed

    Hasebe Y, Hasegawa S, Hashimoto N, Toyoda M, Matsumoto K, Umezawa A, Yagami A, Matsunaga K, Mizutani H, Nakata S, Akamatsu H.

    J Dermatol Sci.   Vol. 62 ( 2 ) page： 98-106   2011

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1046/j.1365-2842.1997.00557.x

  3. Formation of rat hepatocyte spheroids on agarose. Reviewed

    Hasebe Y, Okumura N, Koh T, Kazama H, Watanabe G, Seki T, Ariga T.

    Hepatol Res.   Vol. 32 ( 2 ) page： 89-95   2005

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.hepres.2005.03.012

  4. Plasminogen activator/plasmin system regulates formation of the hepatocyte spheroids. Reviewed

    Hasebe Y, Akao M, Okumura N, Izumi T, Koh T, Seki T, Ariga T.

    Biochem Biophys Res Commun.   Vol. 308 ( 4 ) page： 852-7   2003

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/0961203314520840

  5. Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF-β1. Reviewed

    Ohgo S, Hasegawa S, Hasebe Y, Mizutani H, Nakata S, Akamatsu H.

    Exp Dermatol.   Vol. 22 ( 11 ) page： 769   2013

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/exd.12256

  6. Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis. Reviewed

    Ohgo S, Hasegawa S, Hasebe Y, Mizutani H, Nakata S, Akamatsu H.

    Exp Dermatol.   Vol. 24 ( 7 ) page： 552   2015

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/exd.12701

  7. A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture. Reviewed

    Okumura N, Koh T, Hasebe Y, Seki T, Ariga T.

    J Biol Chem.   Vol. 284 ( 24 ) page： 16553-61   2009

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1074/jbc.M109.011452

  8. Dermal CD271+ Cells are Closely Associated with Regeneration of the Dermis in the Wound Healing Process. Reviewed Open Access

    Iwata Y, Hasebe Y, Hasegawa S, Nakata S, Yagami A, Matsunaga K, Sugiura K, Akamatsu H.

    Acta Derm Venereol.     2017

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2340/00015555-2624

    Open Access

    PubMed

  9. Plasminogen activator-plasmin system potentiates the proliferation of hepatocytes in primary culture. Reviewed Open Access

    Akao M, Hasebe Y, Okumura N, Hagiwara H, Seki T, Ariga T.

    Thromb Res.   Vol. 107 ( 3-4 ) page： 169-74   2002

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2188/jea.16.64

    Open Access

  10. Age-related changes of p75 neurotrophin receptor-positive adipose-derived stem cells. Reviewed

    Yamada T, Akamatsu H, Hasegawa S, Yamamoto N, Yoshimura T, Hasebe Y, Inoue Y, Mizutani H, Uzawa T, Matsunaga K, Nakata S.

    J Dermatol Sci.   Vol. 58 ( 1 ) page： 36   2010

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jdermsci.2010.02.003

  11. Site-Specific Expression of HOXA Genes in Skin and its Effect on Skin Elasticity.

    Okuno R, Hasegawa S, Hasebe Y, Kawagishi-Hotta M, Yamada T, Ishii Y, Arima M, Iwata Y, Sugiura K, Akamatsu H

    The Journal of investigative dermatology   Vol. 145 ( 11 ) page： 2789 - 2797.e6   2025.11

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    Language：English  

    DOI： 10.1016/j.jid.2025.04.005

    PubMed

  12. Three-dimensional cultured human skin model replicating a human facial shape enables personalized assessment of UVB damage in various facial areas.

    Miyachi K, Yamada T, Siraishi T, Igarashi T, Okuno R, Hasebe Y, Hirose O, Hasegawa S

    Journal of dermatological science     2025.10

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    Language：English  

    DOI： 10.1016/j.jdermsci.2025.10.002

    PubMed

  13. Genome-wide association studies in the Japanese population identified genetic loci and target gene associated with epidermal turnover

    Okuno, R; Inoue, Y; Hasebe, Y; Igarashi, T; Kawagishi-Hotta, M; Yamada, T; Hasegawa, S

    EXPERIMENTAL DERMATOLOGY   Vol. 32 ( 10 ) page： 1856 - 1863   2023.10

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  14. A genome-wide association study identified a genetic variant associated with hair thinning in Japanese women

    Okuno, R; Igarashi, T; Hasebe, Y; Kawagishi-Hotta, M; Hasegawa, S

    JOURNAL OF COSMETIC DERMATOLOGY   Vol. 22 ( 9 ) page： 2616 - 2618   2023.9

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  15. Senescent cell removal mechanism and stem cells in the skin

    Ogata, Y; Yamada, T; Sanada, A; Hasebe, Y; Matsusue, M; Hirose, O; Noba, S; Sakaida, T; Yashiro, Y; Hasegawa, S

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 143 ( 5 ) page： S249 - S249   2023.5

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  16. Melanin accumulation in dermal stem cells deteriorates their exosome-mediated skin basement membrane construction in solar lentigo

    Miyachi, K; Yamada, T; Sanada, A; Inoue, Y; Hasebe, Y; Arima, M; Iwata, Y; Hasegawa, S; Sugiura, K; Akamatsu, H

    EXPERIMENTAL DERMATOLOGY   Vol. 31 ( 12 ) page： 1881 - 1890   2022.12

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  17. Identification of mitochondrial genetic variants associated with human corneocyte size in Japanese women

    Inoue, Y; Igarashi, T; Hasebe, Y; Kawagishi-Hotta, M; Okuno, R; Yamada, T; Hasegawa, S

    EXPERIMENTAL DERMATOLOGY   Vol. 31 ( 12 ) page： 1944 - 1948   2022.12

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  18. Genome-wide association studies in Japanese women identified genetic loci associated with wrinkles and sagging Open Access

    Okuno, R; Inoue, Y; Hasebe, Y; Igarashi, T; Kawagishi-Hotta, M; Yamada, T; Hasegawa, S

    EXPERIMENTAL DERMATOLOGY   Vol. 31 ( 9 ) page： 1411 - 1420   2022.9

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  19. Analysis of the effect of daily stress on the skin and search for genetic loci involved in the perceived stress of an individual.

    Inoue Y, Hasebe Y, Igarashi T, Kawagishi-Hotta M, Okuno R, Yamada T, Hasegawa S

    Skin health and disease   Vol. 2 ( 3 ) page： e110   2022.9

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    Language：English  

    DOI： 10.1002/ski2.110

    PubMed

  20. Enhanced Type I Collagen Synthesis in Fibroblasts by Dermal Stem/Progenitor Cell-Derived Exosomes Open Access

    Sanada, A; Yamada, T; Hasegawa, S; Ishii, Y; Hasebe, Y; Iwata, Y; Arima, M; Sugiura, K; Akamatsu, H

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 45 ( 7 ) page： 872 - 880   2022.7

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  21. Increase in inhibin beta A/Activin-A expression in the human epidermis and the suppression of epidermal stem/progenitor cell proliferation with aging

    Kawagishi-Hotta, M; Hasegawa, S; Hasebe, Y; Inoue, Y; Okuno, R; Arima, M; Iwata, Y; Sugiura, K; Akamatsu, H

    JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 106 ( 3 ) page： 150 - 158   2022.6

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  22. Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin Reviewed Open Access

    Kawagishi-Hotta, M; Hasegawa, S; Inoue, Y; Hasebe, Y; Arima, M; Iwata, Y; Sugiura, K; Akamatsu, H

    REGENERATIVE THERAPY   Vol. 18   page： 191 - 201   2021.12

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  23. Search for genetic loci involved in the constitution and skin type of a Japanese women using a genome-wide association study Reviewed

    Inoue, Y; Hasebe, Y; Igarashi, T; Kawagishi-Hotta, M; Okuno, R; Yamada, T; Hasegawa, S

    EXPERIMENTAL DERMATOLOGY   Vol. 30 ( 12 ) page： 1787 - 1793   2021.12

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  24. Establishment of Three Types of Immortalized Human Skin Stem Cell Lines Derived from the Single Donor Reviewed Open Access

    Inoue, Y; Hasegawa, S; Hasebe, Y; Kawagishi-Hotta, M; Okuno, R; Yamada, T; Adachi, H; Miyachi, K; Ishii, Y; Sugiura, K; Akamatsu, H

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 44 ( 10 ) page： 1403 - 1412   2021.10

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  25. Senescent cell removal via JAG1-NOTCH1 signalling in the epidermis Reviewed

    Yoshioka, H; Yamada, T; Hasegawa, S; Miyachi, K; Ishii, Y; Hasebe, Y; Inoue, Y; Tanaka, H; Iwata, Y; Arima, M; Sugiura, K; Akamatsu, H

    EXPERIMENTAL DERMATOLOGY   Vol. 30 ( 9 ) page： 1268 - 1278   2021.9

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  26. Gremlin 2 increased in the skin with age as a senescence-associated secretory phenotype factor Reviewed

    Kawagishi-Hotta, M; Hasegawa, S; Hasebe, Y; Sugiura, K; Akamatsu, H

    JOURNAL OF DERMATOLOGY   Vol. 47 ( 12 ) page： 1457 - 1458   2020.12

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  27. Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis Reviewed Open Access

    Kawagishi-Hotta, M; Hasegawa, S; Igarashi, T; Date, Y; Ishii, Y; Inoue, Y; Hasebe, Y; Yamada, T; Arima, M; Iwata, Y; Kobayashi, T; Nakata, S; Sugiura, K; Akamatsu, H

    REGENERATIVE THERAPY   Vol. 11   page： 324 - 330   2019.12

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  28. ENDOGENOUS DERMAL STEM CELLS AS BIOMARKERS FOR SKIN WOUND HEALING Reviewed

    Iwata, Y; Akamatsu, H; Hasebe, Y; Hasegawa, S; Nakata, S; Sugiura, K

    WOUND REPAIR AND REGENERATION   Vol. 27 ( 5 ) page： A1 - A1   2019.9

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    Language：Japanese  

    Web of Science

  29. CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration

    Yamada Takaaki, Hasegawa Seiji, Hasebe Yuichi, Kawagishi-Hotta Mika, Arima Masaru, Iwata Yohei, Kobayashi Tsukane, Numata Shigeki, Yamamoto Naoki, Nakata Satoru, Sugiura Kazumitsu, Akamatsu Hirohiko

    ARCHIVES OF DERMATOLOGICAL RESEARCH   Vol. 311 ( 1 ) page： 55 - 62   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00403-018-1880-2

    Web of Science

    PubMed

  30. Extracellular proteoglycan decorin maintains human hair follicle stem cells

    Miyachi Katsuma, Yamada Takaaki, Kawagishi-Hotta Mika, Hasebe Yuichi, Date Yasushi, Hasegawa Seiji, Arima Masaru, Iwata Yohei, Kobayashi Tsukane, Numata Shigeki, Yamamoto Naoki, Nakata Satoru, Sugiura Kazumitsu, Akamatsu Hirohiko

    JOURNAL OF DERMATOLOGY   Vol. 45 ( 12 ) page： 1403 - 1410   2018.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.14678

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    PubMed

  31. Skin-resident stem cells and wound healing.

    Iwata Y, Akamatsu H, Hasebe Y, Hasegawa S, Sugiura K

    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology   Vol. 40 ( 1 ) page： 1 - 11   2017

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.2177/jsci.40.1

    PubMed

  32. Dermal CD271(+) Cells are Closely Associated with Regeneration of the Dermis in the Wound Healing Process Open Access

    Iwata Yohei, Hasebe Yuichi, Hasegawa Seiji, Nakata Satoru, Yagami Akiko, Matsunaga Kayoko, Sugiura Kazumitsu, Akamatsu Hirohiko

    ACTA DERMATO-VENEREOLOGICA   Vol. 97 ( 5 ) page： 593-600   2017.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2340/00015555-2624

    Open Access

    Web of Science

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Books 3

  1. FRAGRANCE JOURNAL

    長谷部祐一（ Role： Sole author）

    フレグランスジャーナル社  2016.9 

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    Total pages：6   Language：Japanese

  2. Geriatric Medicine

    （ Role： Joint author）

    2015 

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    Language：Japanese

  3. FRAGRANCE JOURNAL

    （ Role： Joint author）

    2013.9 

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    Language：Japanese

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