Updated on 2021/10/19

写真a

 
OHGAMI Nobutaka
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor

Degree 1

  1. 薬学博士 ( 2001.3   熊本大学 ) 

Research Interests 4

  1. 重金属

  2. 騒音

  3. 聴覚

  4. 神経変性疾患

Research Areas 1

  1. Others / Others  / 環境衛生学、衛生化学

Education 2

  1. Kumamoto University   Graduate School, Division of Pharmaceutical Sciences

    - 2001.3

      More details

    Country: Japan

  2. Kumamoto University   Faculty of Pharmaceutical Science

    - 1996.3

      More details

    Country: Japan

Professional Memberships 3

  1. 日本衛生学会   評議員

    2013.4

  2. 日本産業衛生学会

  3. 日本神経科学学会

 

Papers 62

  1. Development of an efficient remediation system with a low cost after identification of water pollutants including phenolic compounds in a tannery built-up area in Bangladesh

    Yuan Tian, Tazaki Akira, Hashimoto Kazunori, Al Hossain M. M. Aeorangajeb, Kurniasari Fitri, Ohgami Nobutaka, Aoki Masayo, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    CHEMOSPHERE   Vol. 280   page: 130959   2021.10

     More details

  2. Reply. Invited Reviewed

    Kagawa T, Tazaki A, Xu H, Ohgami N, Kato M.

    J Allergy Clin Immunol   Vol. 148 ( 2 ) page: 655 - 656   2021.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaci.2021.05.025

    Web of Science

    PubMed

  3. Development of an efficient remediation system with a low cost after identification of water pollutants including phenolic compounds in a tannery built-up area in Bangladesh. Reviewed International coauthorship

    Yuan T, Tazaki A, Hashimoto K, Al Hossain MMA, Kurniasari F, Ohgami N, Aoki M, Ahsan N, Akhand AA, Kato M.

    Chemosphere     2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.chemosphere.2021

  4. Intranasal levels of lead as an exacerbation factor for allergic rhinitis in humans and mice. Reviewed

    Xu H, Ohgami N, Sakashita M, Ogi K, Hashimoto K, Tazaki A, Tong K, Aoki M, Fujieda S, Kato M.

    J Allergy Clin Immunol   Vol. 148 ( 1 ) page: 139 - 147   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaci.2021.03.019

  5. Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome. Reviewed

    Ohgami N, Iizuka A, Hirai H, Yajima I, Iida M, Shimada A, Tsuzuki T, Jijiwa M, Asai N, Takahashi M, Kato M.

    J Biol Chem   Vol. 296   page: 100389   2021.2

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2021.100389

  6. Hair graying with aging in mice carrying oncogenic RET Reviewed International coauthorship

    Iida Machiko, Tazaki Akira, Yajima Ichiro, Ohgami Nobutaka, Taguchi Nobuhiko, Goto Yuji, Kumasaka Mayuko Y., Prevost-Blondel Armelle, Kono Michihiro, Akiyama Masashi, Takahashi Masahide, Kato Masashi

    AGING CELL   Vol. 19 ( 11 )   2020.11

  7. Increased levels of renal damage biomarkers caused by excess exposure to trivalent chromium in workers in tanneries

    Tsuchiyama Tomoyuki, Tazaki Akira, Al Hossain M. M. Aeorangajeb, Yajima Ichiro, Ahsan Nazmul, Akhand Anwarul Azim, Hashimoto Kazunori, Ohgami Nobutaka, Kato Masashi

    ENVIRONMENTAL RESEARCH   Vol. 188   page: 109770   2020.9

     More details

  8. Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water

    Kato Masashi, Ohgami Nobutaka, Ohnuma Shoko, Hashimoto Kazunori, Tazaki Akira, Xu Huadong, Kondo-Ida Lisa, Yuan Tian, Tsuchiyama Tomoyuki, He Tingchao, Kurniasari Fitri, Gu Yishuo, Chen Wei, Deng Yuqi, Komuro Kanako, Tong Keming, Yajima Ichiro

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 25 ( 1 ) page: 16   2020.5

     More details

  9. A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule

    Ohgami Nobutaka, He Tingchao, Oshino-Negishi Reina, Gu Yishuo, Li Xiang, Kato Masashi

    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES   Vol. 83 ( 5 ) page: 215 - 218   2020.3

  10. A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin

    Iida Machiko, Tazaki Akira, Deng Yuqi, Chen Wei, Yajima Ichiro, Kondo-Ida Lisa, Hashimoto Kazunori, Ohgami Nobutaka, Kato Masashi

    CHEMOSPHERE   Vol. 235   page: 713 - 718   2019.11

  11. Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise

    Negishi-Oshino Reina, Ohgami Nobutaka, He Tingchao, Li Xiang, Kato Masashi, Kobayashi Masayoshi, Gu Yishuo, Komuro Kanako, Angelidis Charalampos E.

    ARCHIVES OF TOXICOLOGY   Vol. 93 ( 11 ) page: 3219 - 3228   2019.11

  12. Histological analysis of the skin of Abca1-deleted mice: A potential model for dry skin

    Deng Yuqi, Ohgami Nobutaka, Iida Machiko, Tazaki Akira, Intoh Atsushi, Kondo-Ida Lisa, Lu Rui, Tsuzuki Toyonori, Yokoyama Shinji, Kato Masashi

    EUROPEAN JOURNAL OF DERMATOLOGY   Vol. 29 ( 5 ) page: 549 - 551   2019.9

     More details

  13. Chromium-mediated hyperpigmentation of skin in male tannery workers in Bangladesh

    Al Hossain M. M. Aeorangajeb, Yajima Ichiro, Tazaki Akira, Xu Huadong, Saheduzzaman Md, Ohgami Nobutaka, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    CHEMOSPHERE   Vol. 229   page: 611 - 617   2019.8

  14. Hearing loss in humans drinking tube well water with high levels of iron in arsenic-polluted area

    He Tingchao, Ohgami Nobutaka, Li Xiang, Yajima Ichiro, Negishi-Oshino Reina, Kato Yoko, Ohgami Kyoko, Xu Huadong, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 9028   2019.6

     More details

  15. cVEMP correlated with imbalance in a mouse model of vestibular disorder

    Negishi-Oshino Reina, Ohgami Nobutaka, He Tingchao, Ohgami Kyoko, Li Xiang, Kato Masashi

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 24 ( 1 )   2019.6

  16. Adsorption of molybdenum by melanin

    Chen Wei, Hashimoto Kazunori, Omata Yasuhiro, Ohgami Nobutaka, Tazaki Akira, Deng Yuqi, Kondo-Ida Lisa, Intoh Atsushi, Kato Masashi

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 24 ( 1 ) page: 36   2019.5

     More details

  17. Inhibition of mast cell degranulation by melanin

    Kawamoto Yoshiyuki, Kondo Hiromoto, Hasegawa Mari, Kurimoto Chiharu, Ishii Yuuki, Kato Chihiro, Botei Taishi, Shinya Muneshige, Murate Takashi, Ueno Yuki, Kawabe Masao, Goto Yuko, Yamamoto Ryohei, Iida Machiko, Yajima Ichiro, Ohgami Nobutaka, Kato Masashi, Takeda Kozue

    BIOCHEMICAL PHARMACOLOGY   Vol. 163   page: 178 - 193   2019.5

     More details

  18. Improvement of balance in young adults by a sound component at 100 Hz in music

    Xu Huadong, Ohgami Nobutaka, He Tingchao, Hashimoto Kazunori, Tazaki Akira, Ohgami Kyoko, Takeda Kozue, Kato Masashi

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 16894   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-35244-3

    Web of Science

    PubMed

  19. A disadvantageous effect of adsorption of barium by melanin on transforming activity.

    Omata Y, Yoshinaga M, Yajima I, Ohgami N, Hashimoto K, Higashimura K, Tazaki A, Kato M

    Chemosphere   Vol. 210   page: 384-391   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.chemosphere.2018.07.022

    PubMed

  20. Arsenic level in toenails is associated with hearing loss in humans

    Li Xiang, Ohgami Nobutaka, Yajima Ichiro, Xu Huadong, Iida Machiko, Oshino Reina, Ninomiya Hiromasa, Shen Dandan, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    PLOS ONE   Vol. 13 ( 7 ) page: e0198743   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0198743

    Web of Science

    PubMed

  21. Increased expression level of Hsp70 in the inner ears of mice by exposure to low frequency noise

    Ninomiya Hiromasa, Ohgami Nobutaka, Oshino Reina, Kato Masashi, Ohgami Kyoko, Li Xiang, Shen Dandan, Iida Machiko, Yajima Ichiro, Angelidis Charalampos E., Adachi Hiroaki, Katsuno Masahisa, Sobue Gen, Kato Masashi

    HEARING RESEARCH   Vol. 363   page: 49-54   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.heares.2018.02.006

    Web of Science

    PubMed

  22. A comprehensive study including monitoring, assessment of health effects and development of a remediation method for chromium pollution

    Yoshinaga Masafumi, Ninomiya Hiromasa, Al Hossain M. M. Aeorangajeb, Sudo Makoto, Akhand Anwarul Azim, Ahsan Nazmul, Alim Md. Abdul, Khalequzzaman Md., Iida Machiko, Yajima Ichiro, Ohgami Nobutaka, Kato Masashi

    CHEMOSPHERE   Vol. 201   page: 667 - 675   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.chemosphere.2018.03.026

    Web of Science

    PubMed

  23. Impairment of extra-high frequency auditory thresholds in subjects with elevated levels of fasting blood glucose.

    Das A, Sumit AF, Ahsan N, Kato M, Ohgami N, Akhand AA

    Journal of otology   Vol. 13 ( 1 ) page: 29-35   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.joto.2017.10.003

    PubMed

  24. Manganese in toenails is associated with hearing loss at high frequencies in humans

    Ohgami Nobutaka, Li Xiang, Yajima Ichiro, Oshino Reina, Ohgami Kyoko, Kato Yoko, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    BIOMARKERS   Vol. 23 ( 6 ) page: 533-539   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/1354750X.2018.1458153

    Web of Science

    PubMed

  25. Manganese-Mediated Decrease in Levels of c-RET and Tyrosine Hydroxylase Expression In Vitro

    Kumasaka Mayuko Y., Yajima Ichiro, Ohgami Nobutaka, Ninomiya Hiromasa, Iida Machiko, Li Xiang, Oshino Reina, Tanihata Hiroko, Yoshinaga Masafumi, Kato Masashi

    NEUROTOXICITY RESEARCH   Vol. 32 ( 4 ) page: 661-670   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12640-017-9783-0

    Web of Science

    PubMed

  26. Arsenic-mediated hyperpigmentation in skin via NF-kappa B/endothelin-1 signaling in an originally developed hairless mouse model

    Yajima Ichiro, Kumasaka Mayuko Y., Iida Machiko, Oshino Reina, Tanihata Hiroko, Al Hossain Aeorangajeb, Ohgami Nobutaka, Kato Masashi

    ARCHIVES OF TOXICOLOGY   Vol. 91 ( 11 ) page: 3507-3516   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00204-017-1975-0

    Web of Science

    PubMed

  27. Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice. Reviewed

    Li X, Ohgami N, Omata Y, Yajima I, Iida M, Oshino R, Ohnuma S, Ahsan N, Akhand AA, Kato M.

    Sci Rep   Vol. 7 ( 1 ) page: 6844   2017.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-06096-0.

  28. Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice

    Li Xiang, Ohgami Nobutaka, Omata Yasuhiro, Yajima Ichiro, Iida Machiko, Oshino Reina, Ohnuma Shoko, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 6844   2017.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-06096-0

    Web of Science

    PubMed

  29. EXPOSURE TO DIPHTHERIA TOXIN IMPAIRS BOTH INNER AND OUTER DURING THE JUVENILE PERIOD HAIR CELLS IN C57BL/6 MICE

    Konishi Hiroyuki, Ohgami Nobutaka, Matsushita Aika, Kondo Yuki, Aoyama Yuki, Kobayashi Masaaki, Nagai Taku, Ugawa Shinya, Yamada Akiyofumi, Kato Masashi, Kiyama Hiroshi

    NEUROSCIENCE   Vol. 351   page: 15-23   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuroscience.2017.03.028

    Web of Science

    PubMed

  30. Arsenic-mediated hyperpigmentation in skin via NF-kappa B/endothelin-1 signaling in an originally developed hairless mouse model. Reviewed

    Yajima I, Kumasaka MY, Iida M, Oshino R, Tanihata H, Al Hossain A, Ohgami N, Kato M.

    Arch Toxicol   Vol. 91 ( 11 ) page: 3507-3516   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  31. Amelioration of arsenic-induced toxic effects in mice by dietary supplementation of Syzygium cumini leaf extract

    Barai Milan, Ahsan Nazmul, Paul Nilanjana, Hossain Khaled, Rashid Mohammad Abdur, Kato Masashi, Ohgami Nobutaka, Akhand Anwarul Azim

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page: 167-177   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.79.2.167

    Web of Science

    PubMed

  32. Risk assessment of neonatal exposure to low frequency noise based on balance in mice. Reviewed

    Ohgami N, Oshino R, Ninomiya H, Li X, Kato M, Yajima I, Kato M.

    Front Behav Neurosci   Vol. 11 ( 30 )   2017.2

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fnbeh.2017.00030

  33. Impairments of Inner Ears Caused by Physical Environmental Stresses.

    Ohgami N, Oshino R, Ninomiya H, Li X, Kato M

    Nihon eiseigaku zasshi. Japanese journal of hygiene   Vol. 72 ( 1 ) page: 38-42   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1265/jjh.72.38

    PubMed

  34. Arsenic levels in cutaneous appendicular organs are correlated with digitally evaluated hyperpigmented skin of the forehead but not the sole in Bangladesh residents. Reviewed

    Yajima I, Ahsan N, Akhand AA, Al Hossain MA, Yoshinaga M, Ohgami N, Iida M, Oshino R, Naito M, Wakai K, Kato M.

    J Expo Sci Environ Epidemiol     page: In press   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/jes.2016.70

  35. Manganese-mediated acceleration of age-related hearing loss in mice. Reviewed

    Ohgami N, Yajima I, Iida M, Li X, Oshino R, Kumasaka MY, Kato M.

    Scientific Reports   Vol. 6   page: 36306   2016.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep36306

  36. Epidemiological analysis of the association between hearing and barium in humans. Reviewed

    Ohgami N, Mitsumatsu Y, Ahsan N, Akhand AA, Li X, Iida M, Yajima I, Naito M, Wakai K, Ohnuma S, Kato M.

    J Expo Sci Environ Epidemiol.   Vol. 26 ( 5 ) page: 488-493   2016.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  37. Reply to the commentary "To Gorelenkova Miller and Mieyal (2015): Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases" by Mieyal JJ. Reviewed

    Kato M, Ninomiya H, Maeda M, Ilmiawati C, Al Hossain MM, Yoshinaga M, Ohgami N.

    Arch Toxicol   Vol. 90 ( 6 ) page: 1523-1524   2016.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00204-016-1705-z

  38. Transcription factor LSF (TFCP2) inhibits melanoma growth Reviewed

    Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki T, Inoue Y, Fukushima S, Ihn H, Kyoya M, Ohashi H, Kawakami T, Bennett DC, Kato M

    Oncotarget   Vol. 7 ( 3 ) page: 2379-2390   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.6230

  39. Arsenite-mediated promotion of anchorage-independent growth of HaCaT cells through placental growth factor. Reviewed

    Yajima I, Kumasaka MY, Ohnuma S, Ohgami N, Naito H, Shekhar HU, Omata Y, Kato M.

    J Invest Dermatol.   Vol. 135 ( 4 ) page: 1147-1156   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  40. Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood. Reviewed

    Ohgami N, Yamanoshita O, Thang ND, Yajima I, Nakano C, Wenting W, Ohnuma S, Kato M.

    Environ Pollut.   Vol. 206   page: 456-460   2015

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  41. Commentary to Krishna et al. (2014): Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water

    Arch Toxicol   Vol. 88 ( 5 ) page: 1185-1186   2014

     More details

    Language:English  

  42. Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice

    Ohgami N, Ida-Eto M, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M

    Neurobiology of Aging   Vol. 33 ( 3 ) page: 626.e25-626.e34   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  43. Exposure to low-dose barium by drinking water causes hearing loss in mice

    Ohgami N, Hori S, Ohgami K, Tamura H, Tsuzuki T, Ohnuma S, Kato M

    NeuroToxicology   Vol. 33   page: 1276-1283   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  44. Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing

    Ida-Eto M, Ohgami N, Iida M, Yajima I, Kumasaka MY, Takaiwa K, Kimitsuki T, Sone M, Nakashima T, Tsuzuki T, Komune S, Yanagisawa M, Kato M

    J Biol Chem   Vol. 286 ( 34 ) page: 29621-29626   2011

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  45. Effects of light smoking on extra-high-frequency auditory thresholds in young adults. Reviewed

    Ohgami N, Kondo T, Kato M.

    Toxicol Ind Health.   Vol. 27 ( 2 ) page: 143-147   2011

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  46. c-Ret-mediated hearing loss in mice with Hirschsprung disease

    Proc Natl Acad Sci USA   Vol. 107 ( 29 ) page: 13051-13056   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  47. Zinc finger protein 28 as a novel melanoma-related molecule. Reviewed

    Yajima I, Kumasaka M, Thang ND, Yanagishita T, Ohgami N, Kallenberg D, Naito Y, Yoshikawa T, Sakashita N, Kato M.

    J Dermatol Sci.   Vol. 55 ( 1 ) page: 68-70   2009

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  48. Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Reviewed

    Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F.

    Dev Cell.   Vol. 17 ( 2 ) page: 199-209   2009

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  49. Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development. Reviewed

    Kato M, Ohgami N, Kawamoto Y, Tsuzuki T, Hossain K, Yanagishita T, Ohshima Y, Tsuboi H, Yamanoshita O, Matsumoto Y, Takahashi M, Nakashima I.

    J Invest Dermatol.   Vol. 127 ( 5 ) page: 1244-1249   2007

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  50. Novel hairless RET-transgenic mouse line with melanocytic nevi and anagen hair follicles. Reviewed

    Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Kato Y, Ohno T, Hossain K, Iftakhar-E-Khuda I, Ohgami N, Isobe K, Takahashi M, Nakashima I.

    J Invest Dermatol.   Vol. 126 ( 11 ) page: 2547-2550   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  51. Cholesterol sensing, trafficking, and esterification. Reviewed

    Chang TY, Chang CC, Ohgami N, Yamauchi Y.

    Annu Rev Cell Dev Biol.   Vol. 22   page: 129-157   2006

     More details

    Authorship:Lead author   Language:English  

  52. Roles of endogenously synthesized sterols in the endocytic pathway. Reviewed

    Sugii S, Lin S, Ohgami N, Ohashi M, Chang CC, Chang TY.

    J Biol Chem   Vol. 281 ( 32 ) page: 23191-23206   2006

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  53. Niemann-Pick type C disease and intracellular cholesterol trafficking. Reviewed

    Chang TY, Reid PC, Sugii S, Ohgami N, Cruz JC, Chang CC.

    J Biol Chem   Vol. 280 ( 22 ) page: 20917-20920   2005

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  54. Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. Reviewed

    Ohgami N, Ko DC, Thomas M, Scott MP, Chang CC, Chang TY.

    Proc Natl Acad Sci U S A.   Vol. 101 ( 34 ) page: 12473-12478   2004

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  55. Biotinylated theta-toxin derivative as a probe to examine intracellular cholesterol-rich domains in normal and Niemann-Pick type C1 cells. Reviewed

    Sugii S, Reid PC, Ohgami N, Shimada Y, Maue RA, Ninomiya H, Ohno-Iwashita Y, Chang TY.

    J Lipid Res.   Vol. 44 ( 5 ) page: 1033-1041   2003

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  56. CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes. Reviewed

    Kuniyasu A, Ohgami N, Hayashi S, Miyazaki A, Horiuchi S, Nakayama H.

    FEBS Lett.   Vol. 537   page: 85-90   2003

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  57. Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol. Reviewed

    Sugii S, Reid PC, Ohgami N, Du H, Chang TY.

    J Biol Chem.   Vol. 278 ( 29 ) page: 27180-27189   2003

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  58. Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines. Reviewed

    Cruz JC, Thomas M, Wong E, Ohgami N, Sugii S, Curphey T, Chang CC, Chang TY.

    J Lipid Res.   Vol. 43 ( 8 ) page: 1341-1347   2002

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  59. CD36, serves as a receptor for advanced glycation endproducts (AGE). Reviewed

    Ohgami N, Nagai R, Ikemoto M, Arai H, Miyazaki A, Hakamata H, Horiuchi S, Nakayama H.

    J Diabetes Complications.   Vol. 16 ( 1 ) page: 56-59   2002

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  60. Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products. Reviewed

    Ohgami N, Nagai R, Miyazaki A, Ikemoto M, Arai H, Horiuchi S, Nakayama H.

    J Biol Chem.   Vol. 276 ( 16 ) page: 13348-13355   2001

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  61. Cd36, a member of the class b scavenger receptor family, as a receptor for advanced glycation end products. Reviewed

    Ohgami N, Nagai R, Ikemoto M, Arai H, Kuniyasu A, Horiuchi S, Nakayama H.

    J Biol Chem.   Vol. 276 ( 5 ) page: 3195-3202   2001

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  62. Glibenclamide acts as an inhibitor of acyl-CoA:cholesterol acyltransferase enzyme. Reviewed

    Ohgami N, Kuniyasu A, Furukawa K, Miyazaki A, Hakamata H, Horiuchi S, Nakayama H.

    Biochem Biophys Res Commun.   Vol. 277 ( 2 ) page: 417-422   2000

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Books 1

  1. 色素細胞(第2版)

    山本博章, 大神信孝, 矢嶋伊知朗, 加藤昌志( Role: Joint author)

    慶応義塾大学出版会  2015 

     More details

    Language:Japanese

Research Project for Joint Research, Competitive Funding, etc. 4

  1. 低周波騒音に対する健康リスク評価と防御法の開発

    2015.10 - 2016.9

    JSTマッチングプランナープログラム 

    大神信孝

      More details

    Grant type:Competitive

  2. ロコモティブ症候群の予防化合物の探索

    2012.10 - 2013.9

    JST A-STEP FSステージ探索タイプ  

    大神信孝

      More details

    Grant type:Competitive

  3. 難聴予防化合物の作用機序の解析-難聴予防食品の開発に向けて-

    2010.10 - 2011.9

    JST A-STEP FSステージ探索タイプ  

    大神信孝

      More details

    Grant type:Competitive

  4. 難聴予防化合物の探索―加齢性難聴予防食品の開発に向けてー

    2009.10 - 2010.9

    JST A-STEP FSステージ探索タイプ  

    大神信孝

      More details

    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. 平衡感覚障害を誘導する有害元素の特定と予防法の開発

    Grant number:20K21708  2020.7 - 2023.3

    科学研究費助成事業  挑戦的研究(萌芽)

    大神 信孝, 橋本 和宜, 杉本 賢文

      More details

    Authorship:Principal investigator 

    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

    有害元素の曝露は難聴(内耳のコルチ器の障害)のリスクを増大させる事が報告されているが、平衡感覚 (内耳の前庭)への影響は不明な点が多い。本研究は、疫学研究と前庭の機能解析や元素イメージング等で評価する実験研究の融合により、ヒトとマウスで平衡感覚障害を誘発する有害元素を特定し、予防法を提案する。

  2. 前庭に影響する新規物理的環境因子のリスク評価と予知・予防法の開発

    Grant number:20H03929  2020.4 - 2025.3

    科学研究費助成事業  基盤研究(B)

    大神 信孝, 橋本 和宜, 加藤 正史

      More details

    Authorship:Principal investigator 

    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

    本研究で解析する環境物理因子は、従来、健康リスク評価法や予防技術も確立されていなかった。代表者らの予備検討により、環境物理因子をマウスに曝露すると前庭がダメージを受け、平衡感覚障害が誘発される事が明らかになり、科学的なエビデンスに基づくリスク評価を実施する事が可能になった。本研究は、マウスを対象にしたリスク評価を用いて、予知・予防法を開発すると共に、ヒトで有効性を検証する。

  3. 宇宙の閉鎖空間を想定した物理的ストレスの複合的影響の解析と防御法の開発

    2018.4 - 2020.3

    科学研究費補助金  新学術領域研究

      More details

    Authorship:Principal investigator 

  4. 宇宙の閉鎖空間を想定した物理的ストレスによる内耳障害のリスク評価と防御法の開発

    2016.4 - 2018.3

    科学研究費補助金  新学術領域研究

      More details

    Authorship:Principal investigator 

  5. 新規環境因子が誘発する難聴の発症機序の解析と予防法の開発

    2016.4 - 2018.3

    科学研究費補助金  基盤研究(C)

    大神信孝

      More details

    Authorship:Principal investigator 

  6. 新規聴力制御分子を標的にした、騒音性難聴の解析と予防法の開発

    2013.4 - 2017.3

    科学研究費補助金  基盤研究(C)

    大神信孝

      More details

    Authorship:Principal investigator 

  7. 新規難聴モデルマウスを用いた、環境ストレスに対する内耳の防御機構の解析

    2011.4 - 2013.3

    科学研究費補助金  若手研究(B)

    大神信孝

      More details

    Authorship:Principal investigator 

  8. 環境ストレスに対する内耳機能保護因子の解析と加齢性難聴の予防・治療薬の開発

    2008.4 - 2010.3

    科学研究費補助金  若手研究(B)

    大神信孝

      More details

    Authorship:Principal investigator 

  9. 小児先天性疾患、ニーマンピックC病及びヒルシュスプリング病の発症機序の解析

    2006.4 - 2008.3

    科学研究費補助金  若手研究(B)

    大神信孝

      More details

    Authorship:Principal investigator 

▼display all