Faculty Profiles - MIYATA Seiko

Association of sleep-wake state discrepancy and depressive symptoms with restorative sleep in patients with depression. Open Access

Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Noda A, Ozaki N, Ikeda M

Sleep medicine Vol. 127 page： 166 - 169 2025.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Sleep Medicine

Objective: One of the common symptoms of mood disorders is insomnia, and the recovery processes can be negatively impacted by a lack of restorative sleep. Although factors related to restorative sleep in healthy subjects have been investigated, evaluations of these factors in patients with depression have been rarely done. Patients with depression are known to have sleep-wake state discrepancy, which can further influence their restorative sleep beyond that associated with depressive symptoms. Thus, we investigated restorative sleep in depressed patients in our current study, and attempted to identify associated factors, with a particular focus on sleep-wake state discrepancy. Methods: In the 91 participants evaluated in this cross-sectional study, all subjects filled out questionnaires on their symptoms prior to undergoing polysomnography (PSG). Sleep duration and restorative sleep were evaluated on the morning after the PSG. The association between restorative sleep and various factors was then examined using multiple regression analysis. Results: A negative association with restorative sleep was found through multiple regression analysis for depressive symptoms (β = −0.055, p = 0.007), daytime sleepiness (β = −0.106, p = 0.020), and overestimation of wake after sleep onset (β = −0.006, p = 0.030). Conclusions: By subjectively and objectively assessing sleep, addressing depressive symptoms, and implementing appropriate sleep hygiene, clinicians could be able to improve restorative sleep in depressed patients.

DOI： 10.1016/j.sleep.2025.01.021

MR Imaging Indices for Brain Interstitial Fluid Dynamics and the Effects of Orexin Antagonists on Sleep

Taoka Toshiaki, Iwamoto Kunihiro, Miyata Seiko, Ito Rintaro, Nakamichi Rei, Nakane Toshiki, Okada Ippei, Ichikawa Kazushige, Kan Hirohito, Kamagata Koji, Kikuta Junko, Aoki Shigeki, Fujimoto Akihiro, Kogo Yuki, Ichinose Nobuyasu, Naganawa Shinji, Ozaki Norio

Magnetic Resonance in Medical Sciences Vol. advpub ( 0 ) 2025.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Magnetic Resonance in Medicine

Purpose: The purpose of this study was to assess the extent to which improvement in sleep with lemborexant contributed to changes in interstitial fluid dynamics.Methods: The 3 methods including diffusion tensor image analysis along the perivascular space (DTI-ALPS), dynamic contrast-enhanced method to assess tissue vascular permeability (Ktrans), and choroid plexus volume (CPV) were used. Correlations between these imaging indices and sleep parameters (latency to persistent sleep [LPS], wake after sleep onset [WASO], total sleep time [TST], and sleep efficiency [SE]) were evaluated using Pearson correlation analysis. Additionally, multiple regression analysis and linear mixed model analysis were employed to assess the relationship between baseline sleep status and imaging parameter changes. MRI and sleep assessments were performed before treatment initiation (week 0, w0) and at 12 weeks after lemborexant administration (week 12, w12).Results: The ALPS-index was inversely correlated with LPS and positively correlated with TST and SE at w0. In multiple regression analysis, ALPS-index was lower when sleep parameters other than LPS were poor at w0. A linear mixed model analysis suggested that poor sleep status in LPS and SE at w0 may have an effect on greater ALPS-index. In the evaluation of Ktrans measurement, the single regression analysis showed a statistically significant correlation between the reduction in Ktrans and the shortening in LPS. Examination of CPV and sleep parameters showed a significant negative correlation between TST and CPV at w0 and w12. Multiple regression analysis also showed that TST of w12 had a significant effect on CPV at w12.Conclusion: Our results suggested that poor sleep status is related to the greater change of ALPS-index and CPV improvement after lemborexant administration may be related to in part to sleep parameter improvement.

DOI： 10.2463/mrms.mp.2024-0176

Sleep Deprivation Elevates Resting and Exercise Blood Pressures and Augments Pressor Response at Exercise Onset.

Hori A, Su X, Sagasaki S, Saito R, Suijo K, Miyata S, Hasegawa D, Mizuno M, Hotta N

Medicine and science in sports and exercise 2024.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Medicine and Science in Sports and Exercise

Purpose: Sleep deprivation and elevated blood pressure (BP) increase the risk of cardiovascular diseases. However, the effects of sleep deprivation on BP response, especially at exercise onset remain unclear. We aimed to elucidate the effects of experimental sleep deprivation (ESD) on resting and exercise BPs, including that at exercise onset, and investigate whether a night-time nap during ESD changes the ESD-altered BP. Methods: Twelve healthy young men underwent 2-min submaximal isometric elbow flexion (IEF) exercise to measure BP after 7 days of normal sleep (control trial), 24-h ESD (ESD trial), and ESD with a 2-h night-time nap (ESD+NAP trial), which were randomly performed. Results: ESD significantly elevated the mean arterial pressure (MAP) at rest (85.8 ± 8.0 to 93.3 ± 5.1 mmHg, P = 0.003) and at the last minute of IEF (116.9 ± 13.0 to 126.2 ± 11.8 mmHg, P = 0.003) compared with that observed in the control trial. At IEF onset (the initial 15 s), ESD significantly elevated the MAP (88.7 ± 12.6 to 103.1 ± 8.8 mmHg, P < 0.001) and augmented the MAP responsiveness from baseline, compared with that observed in the control trial (Δ2.9 ± 11.4 to Δ9.8 ± 6.6 mmHg, P = 0.017). The MAP responsiveness in the ESD+NAP trial (Δ7.3 ± 5.2 mmHg) was not significantly different from that in the control trial (P = 0.165) and the ESD trial (P = 0.129). Conclusions: ESD significantly elevated both resting BP and the BP during submaximal isometric exercise and significantly augmented the initial pressor response to the exercise. A 2-h night-time nap during ESD appears to be insufficient to completely attenuate ESD-induced augmented pressor responses.

DOI： 10.1249/MSS.0000000000003640

Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice. Open Access

Mori D, Ikeda R, Sawahata M, Yamaguchi S, Kodama A, Hirao T, Arioka Y, Okumura H, Inami C, Suzuki T, Hayashi Y, Kato H, Nawa Y, Miyata S, Kimura H, Kushima I, Aleksic B, Mizoguchi H, Nagai T, Nakazawa T, Hashimoto R, Kaibuchi K, Kume K, Yamada K, Ozaki N

Translational psychiatry Vol. 14 ( 1 ) page： 138 2024.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Translational Psychiatry

Whole genome analysis has identified rare copy number variations (CNV) that are strongly involved in the pathogenesis of psychiatric disorders, and 3q29 deletion has been found to have the largest effect size. The 3q29 deletion mice model (3q29-del mice) has been established as a good pathological model for schizophrenia based on phenotypic analysis; however, circadian rhythm and sleep, which are also closely related to neuropsychiatric disorders, have not been investigated. In this study, our aims were to reevaluate the pathogenesis of 3q29-del by recreating model mice and analyzing their behavior and to identify novel new insights into the temporal activity and temperature fluctuations of the mouse model using a recently developed small implantable accelerometer chip, Nano-tag. We generated 3q29-del mice using genome editing technology and reevaluated common behavioral phenotypes. We next implanted Nano-tag in the abdominal cavity of mice for continuous measurements of long-time activity and body temperature. Our model mice exhibited weight loss similar to that of other mice reported previously. A general behavioral battery test in the model mice revealed phenotypes similar to those observed in mouse models of schizophrenia, including increased rearing frequency. Intraperitoneal implantation of Nano-tag, a miniature acceleration sensor, resulted in hypersensitive and rapid increases in the activity and body temperature of 3q29-del mice upon switching to lights-off condition. Similar to the 3q29-del mice reported previously, these mice are a promising model animals for schizophrenia. Successive quantitative analysis may provide results that could help in treating sleep disorders closely associated with neuropsychiatric disorders.

DOI： 10.1038/s41398-023-02679-w

Assessment of cognitive function and sleep-wake rhythms in community-dwelling older adults. Open Access

Okuda M, Noda A, Iwamoto K, Hishikawa N, Miyata S, Yasuma F, Taoka T, Ozaki N, Suhr JA, Miyazaki S

Sleep and biological rhythms Vol. 22 ( 1 ) page： 137 - 145 2024.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Sleep and Biological Rhythms

Disruption of the circadian rhythm and sleep–wake cycles is a consequence of aging and is associated with the cognitive decline and many neurodegenerative conditions. We investigated the bedtime, wake-up time, sleep timing (midpoint between bedtime and wake-up time), and sleep timing standard deviation (SD) using the actigraphy among 80 consecutive volunteers aged ≥ 60 years. Global cognitive function and executive function of detailed cognitive domains were evaluated using the mini-mental state examination (MMSE) and Wisconsin card sorting test (WCST) and subjective daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). The category achievement (CA), total errors (TE), perseverative errors of Nelson (PEN), non-perseverative errors (NPE), and difficulties in maintaining set (DMS) on the WCST were significantly correlated with sleep timing SD (CA: r = − 0.276, p = 0.013, TE: r = 0.311, p = 0.005, PEN: r = 0.241, p = 0.032, NPE: r = 0.250, p = 0.025, DMS: r = 0.235, p = 0.036), but not with the MMSE score. Multiple regression analyses with the stepwise forward selection method including age, ESS score, bedtime, sleep timing, and sleep timing SD, revealed that the ESS score, and sleep timing SD were significant factors related to CA on the WCST (ESS score: β = − 0.322, p = 0.004; sleep timing SD: β = − 0.250, p = 0.022). Assessment of sleep–wake rhythms, daytime sleepiness, and cognitive function using the MMSE and WCST is valuable for the prediction of cognitive decline in the geriatric population.

DOI： 10.1007/s41105-023-00491-z

Assessing the Real-World, Long-Term Impact of Lemborexant on Sleep Quality in a Home-Based Clinical Study. Open Access

Miyata S, Iwamoto K, Okada I, Fujimoto A, Kogo Y, Mori D, Amano M, Matsuyama N, Nishida K, Ando M, Taoka T, Naganawa S, Ozaki N

Nature and science of sleep Vol. 16 page： 291 - 303 2024

Language：English Publishing type：Research paper (scientific journal) Publisher：Nature and Science of Sleep

Purpose: Both subjective and objective evaluations are essential for the treatment of insomnia. Lemborexant has been shown to be effective in the long-term based solely on a subjective basis, and no long-term objective measures have been evaluated under natural sleep conditions. Small, lightweight sleep electroencephalogram (EEG) monitor was used, instead of polysomnography, to objectively evaluate sleep at home 4 and 12 weeks after lemborexant treatment. Patients and Methods: Adults and elderly subjects with insomnia disorder, per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, were enrolled in this open-label, single-arm, single-center trial. Objective and subjective measures of sleep were prospectively assessed. Sleep disturbance, excessive sleepiness, and depressive symptoms were assessed using questionnaires. Results: A total of 45 subjects were screened, of which 33 were enrolled. Paired t-tests were conducted to evaluate changes in sleep variables and compared with the baseline; subjects showed significant improvements in objective sleep efficiency (SE) and subjective sleep parameters at weeks 4 and 12 following treatment with lemborexant. When baseline values were taken into account, a repeated-multivariate analysis of variance (MANOVA) revealed statistically significant changes in the objective measures. Sleep disturbance, excessive sleepiness, and depressive symptoms improved after three months of lemborexant treatment. Conclusion: Furthermore, lemborexant therapy improved nocturnal sleep, when measured objectively using sleep EEG monitoring at home, and improved daytime sleepiness and depressive symptoms in older adults with insomnia disorder.

DOI： 10.2147/NSS.S448871

LPS and its relationship with subjective-objective discrepancies of sleep onset latency in patients with psychiatric disorders.

Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Ando M, Noda A, Ozaki N

Scientific reports Vol. 13 ( 1 ) page： 22637 2023.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports

Subjective–objective discrepancies in sleep onset latency (SOL), which is often observed among psychiatric patients, is attributed partly to the definition of sleep onset. Recently, instead of SOL, latency to persistent sleep (LPS), which is defined as the duration from turning out the light to the first consecutive minutes of non-wakefulness, has been utilized in pharmacological studies. This study aimed to determine the non-awake time in LPS that is most consistent with subjective sleep onset among patients with psychiatric disorders. We calculated the length of non-awake time in 30-s segments from lights-out to 0.5–60 min. The root mean square error was then calculated to determine the most appropriate length. The analysis of 149 patients with psychiatric disorders showed that the optimal non-awake time in LPS was 12 min. On the other hands, when comorbid with moderate or severe obstructive sleep apnea (OSA), the optimal length was 19.5 min. This study indicates that 12 min should be the best fit for the LPS non-awake time in patients with psychiatric disorders. When there is comorbidity with OSA, however, a longer duration should be considered. Measuring LPS minimizes discrepancies in SOL and provides important clinical information.

DOI： 10.1038/s41598-023-49261-4

Comparison of Polysomnography, Single-Channel Electroencephalogram, Fitbit, and Sleep Logs in Patients With Psychiatric Disorders: Cross-Sectional Study. Open Access

Kawai K, Iwamoto K, Miyata S, Okada I, Fujishiro H, Noda A, Nakagome K, Ozaki N, Ikeda M

Journal of medical Internet research Vol. 25 ( 1 ) page： e51336 2023.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Medical Internet Research

Background: Sleep disturbances are core symptoms of psychiatric disorders. Although various sleep measures have been developed to assess sleep patterns and quality of sleep, the concordance of these measures in patients with psychiatric disorders remains relatively elusive. Objective: This study aims to examine the degree of agreement among 3 sleep recording methods and the consistency between subjective and objective sleep measures, with a specific focus on recently developed devices in a population of individuals with psychiatric disorders. Methods: We analyzed 62 participants for this cross-sectional study, all having data for polysomnography (PSG), Zmachine, Fitbit, and sleep logs. Participants completed questionnaires on their symptoms and estimated sleep duration the morning after the overnight sleep assessment. The interclass correlation coefficients (ICCs) were calculated to evaluate the consistency between sleep parameters obtained from each instrument. Additionally, Bland-Altman plots were used to visually show differences and limits of agreement for sleep parameters measured by PSG, Zmachine, Fitbit, and sleep logs. Results: The findings indicated a moderate agreement between PSG and Zmachine data for total sleep time (ICC=0.46; P<.001), wake after sleep onset (ICC=0.39; P=.002), and sleep efficiency (ICC=0.40; P=.006). In contrast, Fitbit demonstrated notable disagreement with PSG (total sleep time: ICC=0.08; wake after sleep onset: ICC=0.18; sleep efficiency: ICC=0.10) and exhibited particularly large discrepancies from the sleep logs (total sleep time: ICC=–0.01; wake after sleep onset: ICC=0.05; sleep efficiency: ICC=–0.02). Furthermore, subjective and objective concordance among PSG, Zmachine, and sleep logs appeared to be influenced by the severity of the depressive symptoms and obstructive sleep apnea, while these associations were not observed between the Fitbit and other sleep instruments. Conclusions: Our study results suggest that Fitbit accuracy is reduced in the presence of comorbid clinical symptoms. Although user-friendly, Fitbit has limitations that should be considered when assessing sleep in patients with psychiatric disorders.

DOI： 10.2196/51336

Evaluating sleep-wake rhythm using a wearable device in patients with mental disorders.

Assessment of cognitive function and sleep-wake rhythms in community-dwelling older adults

Okuda Masato, Noda Akiko, Iwamoto Kunihiro, Hishikawa Nozomi, Miyata Seiko, Yasuma Fumihiko, Taoka Toshiaki, Ozaki Norio, Suhr Julie A., Miyazaki Soichiro

SLEEP AND BIOLOGICAL RHYTHMS 2023.9

Late-onset depressive disorder and psychiatric-onset of prodromal dementia with Lewy bodies

Fujishiro Hiroshige, Torii Youta, Miyata Seiko, Iwamoto Kunihiro

Suicide Prevention and Crisis Intervention Vol. 43 ( 2 ) page： 81 - 89 2023.9

Miyata S, Iwamoto K, Ozaki N

Psychiatry and clinical neurosciences Vol. 77 ( 8 ) page： 419 - 419 2023.8

LONG-TERM EFFICACY OF LEMBOREXANT ON OBJECTIVE SLEEP MEASURES IN CLINICAL PRACTICE

Miyata Seiko, Iwamoto Kunihiro, Okada Ippei, Fujimoto Akihiro, Kogo Yuki, Amano Manabu, Matsuyama Nao, Ozaki Norio

SLEEP Vol. 46 2023.5

Temporal trajectories of proposed biomarkers in psychiatric-onset prodromal dementia with Lewy bodies: a case report.

Fujishiro H, Arafuka S, Ogasawara K, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society Vol. 23 ( 1 ) page： 196 - 200 2023.1

Feasibility of a wrist-worn wearable device for estimating mental health status in patients with mental illness. Open Access

Nakagome K, Makinodan M, Uratani M, Kato M, Ozaki N, Miyata S, Iwamoto K, Hashimoto N, Toyomaki A, Mishima K, Ogasawara M, Takeshima M, Minato K, Fukami T, Oba M, Takeda K, Oi H

Frontiers in psychiatry Vol. 14 page： 1189765 2023

Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers in Psychiatry

Object: Real-world data from wearable devices has the potential to understand mental health status in everyday life. We aimed to investigate the feasibility of estimating mental health status using a wrist-worn wearable device (Fitbit Sense) that measures movement using a 3D accelerometer and optical pulse photoplethysmography (PPG). Methods: Participants were 110 patients with mental illnesses from different diagnostic groups. The study was undertaken between 1 October 2020 and 31 March 2021. Participants wore a Fitbit Sense on their wrist and also completed the State–Trait Anxiety Inventory (STAI), Positive and Negative Affect Schedule (PANAS), and EuroQol 5 dimensions 5-level (EQ-5D-5L) during the study period. To determine heart rate (HR) variability (HRV), we calculated the sdnn (standard deviation of the normal-to-normal interval), coefficient of variation of R-R intervals, and mean HR separately for each sleep stage and the daytime. The association between mental health status and HR and HRV was analyzed. Results: The following significant correlations were found in the wake after sleep onset stage within 3 days of mental health status assessment: sdnn, HR and STAI scores, HR and PANAS scores, HR and EQ-5D-5L scores. The association between mental health status and HR and HRV was stronger the closer the temporal distance between mental health status assessment and HR measurement. Conclusion: A wrist-worn wearable device that measures PPG signals was feasible for use with patients with mental illness. Resting state HR and HRV could be used as an objective assessment of mental health status within a few days of measurement.

DOI： 10.3389/fpsyt.2023.1189765

Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems.

Okada I, Miyata S, Iwamoto K, Fujishiro H, Noda A, Ozaki N

Sleep & breathing = Schlaf & Atmung Vol. 26 ( 4 ) page： 1983 - 1991 2022.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Sleep and Breathing

Purpose: Patients with psychiatric disorders often complain of sleep disturbances and are frequently suspected of obstructive sleep apnea (OSA). However, data regarding sleep problems evaluated by attended polysomnography (PSG) remain limited in this population. We analyzed the results of attended PSG from psychiatric patients with sleep-related problems to determine the prevalence and features of sleep disorders among this population. Methods: We retrospectively investigated the attended PSG results of patients with psychiatric disorders: major depressive disorder, bipolar disorder, neurodevelopmental disorder, schizophrenia, neurocognitive disorder, anxiety disorder, somatic symptom disorder. Results: Of 264 patients, 158 men (60%), mean age was 47 ± 19.9 years. More than half of the patients with major depressive disorder (62%), bipolar disorder (70%), schizophrenia (58%), neurocognitive disorders (55%), and somatic symptom disorder (56%) had OSA. Among the psychiatric patients with OSA, 62% of these patients had moderate to severe OSA. The risk factors for OSA were snoring, male, age, and body mass index. The presence of OSA was not associated with the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale score, or benzodiazepine, antipsychotic, or antidepressant use. Other sleep disorders were insomnia (19%), central disorders of hypersomnia (8%), restless legs syndrome/periodic limb movement of sleep (8%), rapid eye movement sleep behavior disorder (7%), and central sleep apnea syndrome (3%). Conclusions: PSG revealed that moderate to severe OSA was common in psychiatric patients with or without snoring. Subjective symptoms and psychotropics did not predict OSA. Therefore, PSG is needed to reveal sleep conditions in patients with psychiatric disorders.

DOI： 10.1007/s11325-022-02566-6

Web of Science

FLUID study: study protocol for an open-label, single-centre pilot study to investigate the efFect of Lemborexant on sleep management in Japanese sUbjects aged 50 years and older with Insomnia Disorder. Open Access

Polysomnographic characteristics and predictors of positional obstructive sleep apnea in Japanese elderly. Open Access

Miyata S, Otake H, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N

Sleep and biological rhythms Vol. 20 ( 3 ) page： 403 - 411 2022.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Sleep and Biological Rhythms

Sleep problems and obstructive sleep apnea (OSA) increase with age and disturb life in old age. Positional therapy is one option to treat OSA, but the differences in clinical pathophysiology between elderly and other age groups have not been fully investigated. We explored the pathophysiological features of sleep apnea, factors that are independently associated with positional OSA and the prevalence in elderly patients. We studied demographic and polysomnographic data of 85 elderly individuals with OSA (age ≥ 65 years) and 124 non-elderly patients with OSA (age, 20–64 years). The Amsterdam Positional OSA Classification (APOC) was used to evaluate positional OSA. Body mass index (BMI) and Epworth sleepiness scale were both significantly lower in the elderly group than in the non-elderly group, although apnea/hypopnea index (AHI) did not differ between groups. OSA severity affected total sleep time, sleep efficiency, and waking after sleep onset more in the elderly than in the non-elderly. AHI in the lateral position was significantly lower in elderly than in non-elderly, although AHI in the supine position was almost the same between two groups. The distribution of APOC 1 and 2 (lateral sleep effective) was significantly higher in the elderly than in the non-elderly. Relative factors such as BMI, rate of hypopnea, and lowest SpO2 associated with positional OSA in non-elderly groups did not differ significantly among APOC subgroups in elderly patients. Our findings are suggesting that characteristics of the positional OSA is different between elderly and younger-age OSA patients.

DOI： 10.1007/s41105-022-00385-6

A Study of Factors Causing Sleep State Misperception in Patients with Depression. Open Access

Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Noda A, Ozaki N

Nature and science of sleep Vol. 14 page： 1273 - 1283 2022

Language：English Publishing type：Research paper (scientific journal) Publisher：Nature and Science of Sleep

Purpose: Sleep state misperception, which is the discrepancy between subjective and objective sleep, is often observed in patients with depression. This phenomenon may delay the remission of depression. Previous studies have focused on the total sleep time (TST) misperception, with many of these studies using actigraphy. Thus, our study investigated depressed patients with the exploratory aim of clarifying factors associated with the sleep state misperception including the wake after sleep onset (WASO) misperception, with their objective sleep additionally evaluated by polysomnography (PSG). Patients and Methods: We conducted a cross-sectional study. Before undergoing overnight PSG monitoring, 40 patients with depression completed questionnaires that included the Beck Depression Inventory (BDI), Epworth sleepiness scale, Temperament and Character Inventory, and the Pittsburgh sleep quality index. Patients were also asked to estimate their subjective sleep duration after they woke up in the morning. Based on this data, we calculated the misperception using the following formula: subjective sleep duration minus objective sleep duration. We compared each factor between negative and positive misperception groups and the multiple regression analysis was performed for TST and WASO misperception, respectively. Results: Although sleep architectures, age, severity of depression and obstructive sleep apnea (OSA) exhibited differences in underestimating or overestimating the WASO, only sex differences were associated with underestimating or overestimating their total sleep time (TST). Moreover, BDI, the severity of OSA, sleep architectures (N1% and N2%), and benzodiazepine (BZD) use were significantly correlated with WASO misperception, whereas only OSA severity was significantly correlated with TST misperception. A subsequent multiple regression analysis demonstrated the BDI was independently correlated with the WASO misperception (β=0.341, p=0.049). Conclusion: In clinical practice, interventions especially for OSA, and the reduction of depressive symptoms are an important method for improving patient sleep perception. Moreover, current results suggest that BZD prescriptions should be avoided as well.

DOI： 10.2147/NSS.S366774

Okada I, Iwamoto K, Miyata S, Fujimoto A, Tanaka M, Amano M, Matsuyama N, Taoka T, Naganawa S, Ozaki N

BMJ open Vol. 11 ( 11 ) page： e054885 2021.11

Language：English Publishing type：Research paper (scientific journal) Publisher：BMJ Open

Introduction Bidirectional associations have been reported between sleep disturbance and both cognitive impairment, including Alzheimer’s disease and amyloid beta-peptide (Aβ) accumulation. These relationships can be explained by the glymphatic system, which acts as a garbage drainage system in the brain. As interstitial fluid dynamics are suggested to increase during sleep, clearance of Aβ can be influenced by sleep disturbance or deprivation. We hypothesised that using lemborexant, an orexin receptor antagonist, to improve sleep quality would also improve the function of the glymphatic system. We plan to examine the effect of lemborexant on sleep quality and the glymphatic system among patients with insomnia disorder. Methods and analysis This pilot study is designed as an open-label, single-arm, single-centre trial. Thirty patients aged 50 years and over with insomnia will be recruited. The participants will take lemborexant (5 mg) at bedtime for 12 weeks and undergo a home-based sleep study at baseline and weeks 4 and 12, as well as MRI examinations to evaluate the glymphatic system at baseline and week 12. The primary outcome will be changes in objective sleep parameters as evaluated using a sleep monitoring system. The secondary outcomes will be changes in subjective sleep parameters. The relationships between changes in sleep parameters and the glymphatic system will be evaluated using diffusion tensor image analysis along the perivascular space, which is called the ALPS-index. Sleep parameters and the ALPS-index will be analysed using a paired t-test or Pearson’s correlation coefficient. Ethics and dissemination The study protocol was approved by Nagoya University Certified Review Board. The findings from this research will be published in peer-reviewed journals and be presented at local, national and international conferences.

DOI： 10.1136/bmjopen-2021-054885

Performance of an ambulatory electroencephalogram sleep monitor in patients with psychiatric disorders.

Miyata S, Iwamoto K, Banno M, Eguchi J, Kaneko S, Noda A, Ozaki N

Journal of sleep research Vol. 30 ( 4 ) page： e13273 2021.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Sleep Research

Key clinical symptoms observed among individuals with psychiatric disorders include difficulty falling asleep or maintaining sleep, poor sleep quality and nightmares. Those suffering from sleep disorders often present with symptoms of discontent with regard to sleep quality, timing and quantity, and these symptoms have an adverse impact on function and quality of life. A minimally invasive technique would be preferable in patients with psychiatric disorders, who tend to be sensitive to environmental change. Accordingly, we evaluated the performance of Zmachine Insight Plus, an ambulatory electroencephalography sleep monitor, in patients with psychiatric disorders. One hundred and three patients undergoing polysomnography were enrolled in this study. Zmachine Insight Plus was performed simultaneously with polysomnography. Total sleep time, sleep efficiency, wake after sleep onset, rapid eye movement (REM) sleep, light sleep (stages N1 and N2) and deep sleep (stage N3) were assessed. Total sleep time, sleep efficiency, wake after sleep onset, REM sleep duration and non-REM sleep duration of Zmachine Insight Plus showed a significant correlation with those of polysomnography. Lower sleep efficiency and increased frequency of waking after sleep onset, the arousal index and the apnea–hypopnea index on polysomnography were significantly associated with the difference in sleep parameters between the two methods. Among patients with psychiatric disorders who are sensitive to environmental change, Zmachine Insight Plus would be a useful technique to objectively evaluate sleep quality.

DOI： 10.1111/jsr.13273

Web of Science

Consideration for daily preventive measures to lead a healthy and comfortable life

Effects of age and sex on eye movement characteristics. Open Access

Takahashi J, Miura K, Morita K, Fujimoto M, Miyata S, Okazaki K, Matsumoto J, Hasegawa N, Hirano Y, Yamamori H, Yasuda Y, Makinodan M, Kasai K, Ozaki N, Onitsuka T, Hashimoto R

Neuropsychopharmacology reports Vol. 41 ( 2 ) page： 152 - 158 2021.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Neuropsychopharmacology Reports

Abnormal eye movements are often associated with psychiatric disorders. Eye movements are sensorimotor functions of the brain, and aging and sex would affect their characteristics. A precise understanding of normal eye movements is required to distinguish disease-related abnormalities from natural differences associated with aging or sex. To date, there is no multicohort study examining age-related dependency and sex effects of eye movements in healthy, normal individuals using large samples to ensure the robustness and reproducibility of the results. In this study, we aimed to provide findings showing the impact of age and sex on eye movement measures. The present study used eye movement measures of more than seven hundred healthy individuals from three large independent cohorts. We herein evaluated eye movement measures quantified by using a set of standard eye movement tests that have been utilized for the examination of patients with schizophrenia. We assessed the statistical significance of the effects of age and sex and its reproducibility across cohorts. We found that 4-18 out of 35 eye movement measures were significantly correlated with age, depending on the cohort, and that 10 of those, which are related to the fixation and motor control of smooth pursuit and saccades, showed high reproducibility. On the other hand, the effects of sex, if any, were less reproducible. The present results suggest that we should take age into account when we evaluate abnormalities in eye movements.

DOI： 10.1002/npr2.12163

Sleep fragmentation and working memory in healthy adults. Open Access

Okuda M, Noda A, Mabuchi S, Iwamoto K, Banno M, Miyata S, Yasuma F, Ozaki N

Sleep science (Sao Paulo, Brazil) Vol. 14 ( Spec 2 ) page： 111 - 117 2021.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Sleep Science

Introduction: Sleep is essential for performing cognitive function in humans. We have hypothesized that sleep fragmentation compared to sleep efficiency may have a negative impact on the working memory. Material and Methods: Twenty-eight healthy adults (18 males and 10 females; mean age 27.8±15.5 years) were enrolled in this study. We measured the total sleep time (TST), sleep efficiency, %stage wakefulness (W), %stage rapid eye movement (REM), %stage N1, %stage N2, %stage N3, wake after sleep onset (WASO), and arousal index using polysomnography. Working memory, executive function, and sustained attention of three domains of cognitive function were evaluated with the number of back task (N-back task), Wisconsin card sorting test (WCST), and continuous performance test-identical pairs (CPT-IP), respectively. Results: The percentage of correct answers on the 2-back task was significantly correlated with %stage REM, %stage N1, and %stage N2 (%stage REM: r=0.505, p=0.006; %stage N1: r=-0.637, p<0.001; %stage N2: r=0.670, p<0.001), and multiple regression analysis including the stepwise forward selection method revealed that %stage N2 was the most significant factor (%stage N2: β=0.670, p<0.001). The percentage of correct answers on the 2-back task was also significantly correlated with TST, sleep efficiency, WASO, and arousal index (TST: r=0.492, p=0.008; sleep efficiency: r=0.622, p<0.001; WASO: r=-0.721, p<0.001; arousal index: r=-0.656, p<0.001), and WASO was the significant factor (β=-2.086, p=0.007). The WCST category achievement and CPT-IP d-prime score were correlated with none of the sleep variables. Conclusion: Increased WASO and a decrease in %stage N2 were associated with worse working memory.

DOI： 10.5935/1984-0063.20200088

Effects of long sleep time and irregular sleep-wake rhythm on cognitive function in older people. Open Access

Okuda M, Noda A, Iwamoto K, Nakashima H, Takeda K, Miyata S, Yasuma F, Ozaki N, Shimouchi A

Scientific reports Vol. 11 ( 1 ) page： 7039 2021.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports

Sleep disturbances and cognitive decline are common in older adults. We aimed to investigate the effects of the total sleep time (TST) and sleep–wake rhythm on executive function and working memory in older adults. In 63 older participants, we measured the TST, wake after sleep onset (WASO), and sleep timing (midpoint between bedtime and wake-up time) using actigraphy. Executive function was evaluated with the trail making test B (TMT-B) and Wisconsin card sorting test (WCST). The number of back task (N-back task) was used to measure working memory. Participants with a TST ≥ 8 h had a significantly lower percentage of correct answers (% correct) on the 1-back task than those with a TST < 8 h. The % correct on the 1-back task was significantly correlated with the TST, WASO, and sleep timing. Multiple regression analyses revealed that the TST and sleep timing were significant factors of the % correct on the 1-back task. The TMT-B score was significantly correlated with the sleep timing. Category achievement on the WCST was significantly correlated with the standard deviation of the sleep timing. Therefore, a long sleep time and an irregular sleep–wake rhythm could have adverse effects on executive function and working memory in older people.

DOI： 10.1038/s41598-021-85817-y

The Society of Heating, Air-Conditioning and Sanitary Engineers of Japan, Chubu, Vol. 22 ( 0 ) page： 77 - 80 2021

Patient characteristics affecting accurate detection of sleep apnea using a bed sheet-type portable monitor

Miyata Seiko, Otake Hironao, Ando Motoo, Okuda Masato, Fujishiro Hiroshige, Iwamoto Kunihiro, Noda Akiko, Sone Michihiko, Ozaki Norio

SLEEP AND BREATHING Vol. 24 ( 2 ) page： 783 - 790 2020.6

SLEEP MONITORING WITH A SINGLE CHANNEL EEG RECORDER IN PATIENTS WITH PSYCHIATRIC DISORDERS

Miyata S., Iwamoto K., Banno M., Ito Y., Noda A., Ozaki N.

SLEEP Vol. 43 page： A220 - A221 2020.4

Effects of sleep-disordered breathing and hypertension on cognitive function in elderly adults

Kato Kazuko, Noda Akiko, Yasuma Fumihiko, Matsubara Yuka, Miyata Seiko, Iwamoto Kunihiro, Miyazaki Soichiro, Ozaki Norio

CLINICAL AND EXPERIMENTAL HYPERTENSION Vol. 42 ( 3 ) page： 250 - 256 2020

認知症と睡眠障害

宮田聖子

日本臨牀 Vol. 78 page： 567 - 571 2020

高齢者の不眠、過眠、薬物療法が運転に及ぼす影響と指導法を教えてください

宮田聖子

老年医学 Vol. 58 page： 433 - 436 2020

Clinical profiles of late-onset psychiatric patients exhibiting incidental REM sleep without atonia

Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Torii Youta, Iritani Shuji, Ozaki Norio

JOURNAL OF NEURAL TRANSMISSION Vol. 126 ( 8 ) page： 1095 - 1104 2019.8

CUFF-LESS BLOOD PRESSURE MONITORING DURING SLEEP

Noda A., Mita Y., Miyata S., Ando M., Okumura T.

JOURNAL OF HYPERTENSION Vol. 37 page： E254 - E254 2019.7

Effect of Valvular Regurgitation on Left Ventricular Function in Middle-aged and Elderly

MIYATA Seiko, NODA Akiko

Journal of Clinical Physiology Vol. 49 ( 2 ) page： 89 - 96 2019.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Clinical Physiology

Background: Valvular regurgitation, a degenerative condition, increases in prevalence with age. Its impact on left ventricular (LV) function in the elderly remains unclear, however.Objective: The purpose of this study was to characterize the relationship between LV function and valvular regurgitation in middle-aged and elderly.Methods: Echocardiography was performed to assess LV systolic and diastolic function in 98 community-dwelling middle-aged and older adults. Mitral regurgitation (MR) and aortic regurgitation (AR) were qualitatively graded from absent or trivial to severe.Results: The LV ejection fraction was significantly higher and the deceleration time at the mitral level during rapid filling significantly longer in the MR group than in the non-MR group. The ratio of early diastolic wave peak velocity to mitral annular early diastolic peak velocity was significantly greater in the AR group than in the non-AR group.Conclusions: Both MR and AR may play an important role in change in LV systolic and diastolic function, even in cases of mild regurgitation, in middle-aged and elderly.

DOI： 10.34363/jocp.49.2_89

Delayed sleep/wake rhythm and excessive daytime sleepiness correlate with decreased daytime brain activity during cognitive task in university students

EFFECTS OF AROMATHERAPY ON SLEEP AND COGNITIVE FUNCTION IN THE ELDERLY

Noda Akiko, Funaki Narumi, Hirashita Rie, Nakashima Honoka, Mita Yasuaki, Masato Okuda, Miyata Seiko, Iwamoto Kunihiro, Ozaki Norio, Urakami Katsuya

SLEEP Vol. 42 page： . 2019.4

DIFFERENCES IN SLEEP DURATION AND QUALITY BETWEEN WEEKDAYS AND WEEKENDS IN JAPANESE ADULTS

Miyata Seiko, Iwamoto Kunihiro, Ando Motoo, Ito Yuki, Noda Aiko, Ozaki Norio

SLEEP Vol. 42 page： . 2019.4

Miyata Seiko, Noda Akiko, Kawai Sayumi, Honda Kumiko, Iwamoto Kunihiro, Ozaki Norio, Miyazaki Soichiro, Kondo Takaharu

BIOLOGICAL RHYTHM RESEARCH Vol. 50 ( 2 ) page： 171 - 179 2019.3

Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder.

Shishido E, Ogawa S, Miyata S, Yamamoto M, Inada T, Ozaki N

Neuropsychopharmacology reports 2019.2

今月の特集1 発症を予測する臨床検査-先制医療で5疾病に立ち向かう! 精神疾患の先制医療

宮田聖子, 尾崎紀夫

臨床検査 Vol. 63 ( 1 ) page： 37 - 41 2019.1

Very low frequency component of heart rate variability as a marker for therapeutic efficacy in patients with obstructive sleep apnea: Preliminary study Open Access

Noda Akiko, Hayano Junichiro, Ito Nami, Miyata Seiko, Yasuma Fumihiko, Yasuda Yoshinari

JOURNAL OF RESEARCH IN MEDICAL SCIENCES Vol. 24 ( 1 ) page： 84 2019

Relationship between Sleep and Lipid Metabolism

MIYATA Seiko, NODA Akiko, IWAMOTO Kunihiro, OZAKI Norio

Oleoscience Vol. 19 ( 7 ) page： 285 - 290 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Oil Chemists' Society

Sleep plays an important role in metabolic regulation and insomnia disorder, short sleep and long sleep are also related with dyslipidemia. Among them especially, numerous evidence suggests that sleep disordered breathing is closely associated with dyslipidemia, hypertension and diabetes, and increases the risk of cardiovascular disease. In addition, in recent years, studies that elucidate the molecular mechanism of dyslipidemia due to sleep disorder by a mass spectrometer is increasing. The relationship between severity and lipid species profile in patients with obstructive sleep apnea has been reported, and the previous study revealed a significant overall shift in lipid metabolism, with higher levels of phospholipids under sleep-restricted conditions. Comprehensive analysis of lipid metabolites using a mass spectrometry further the understanding of sleep/wake regulation and the associated metabolic processes, and will be vital to identify robust biomarkers for disease states and drug efficacy. In this paper, we review epidemiological and mass spectrometric studies on the relationship between sleep and dyslipidemia.

DOI： 10.5650/oleoscience.19.285

Chapter 3: Clinical examination for sleep disorders

Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infrared spectroscopy study

Tsuruta Yoshiyuki, Iwamoto Kunihiro, Banno Masahiro, Kawano Naoko, Kohmura Kunihiro, Miyata Seiko, Fujishiro Hiroshige, Noda Yukihiro, Noda Akiko, Iritani Shuji, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 33 ( 6 ) page： e2678 2018.11

The effect of short sleep on lipid metabolism in Japanese university students

Miyata S., Noda A., Iwamoto K., Fujishiro H., Taguchi R., Ozaki N.

JOURNAL OF SLEEP RESEARCH Vol. 27 page： . 2018.9

Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.

Matsuoka H, Miyata S, Okumura N, Watanabe T, Hashimoto K, Nagahara M, Kato K, Sobue S, Takeda K, Ichihara M, Iwamoto T, Noda A

Clinical and experimental hypertension (New York, N.Y. : 1993) page： 1-5 2018.6

Early diagnosis of Lewy body disease in patients with late-onset psychiatric disorders using clinical history of rapid eye movement sleep behavior disorder and [I-123]-metaiodobenzylguanidine cardiac scintigraphy

Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Torii Youta, Iritani Shuji, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 72 ( 6 ) page： 423-434 2018.6

BENEFICIAL EFFECTS OF POSITIONAL THERAPY ON COGNITIVE FUNCTION IN ELDERLY PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

Noda A., Miyata S., Iwamoto K., Ozaki N.

SLEEP Vol. 41 page： A209 - A209 2018.4

睡眠覚醒制御系を用いた精神障害の分類システム構築

宮田聖子

精神医学 Vol. 60 page： 33 - 41 2018

Effects of lower limb vibrations in the supine position on autonomic activity in healthy adults Reviewed

Noda A, Tsukano S, Miyata S, Inoue S, Honda K, Yasuma F

Br J Res Vol. 4 page： 34 2017.12

POLYSOMNOGRAPHIC AND MORPHOLOGICAL CHARACTERISTICS IN ELDERLY PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

Miyata S., Otake H., Noda A., Okuda M., Ando M., Fujishiro H., Iwamoto K., Ozaki N.

SLEEP MEDICINE Vol. 40 page： E228-E229 2017.12

Influence of sleep duration on cortical oxygenation in elderly individuals Reviewed

Kato K, Miyata S, Ando M, Matsuoka H, Yasuma F, Iwamoto K, Kawano N, Banno M, Ozaki N, Noda A

Psychiatry Clin Neurosci Vol. 71 page： 44-51 2017.11

Nitric Oxide Plasma Level as a Barometer of Endothelial Dysfunction in Factory Workers

Miyata Seiko, Noda Akiko, Hara Yuki, Ueyama Jun, Kitaichi Kiyoyuki, Kondo Takaaki, Koike Yasuo

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES Vol. 125 ( 10 ) page： 684-689 2017.11

Beneficial effects of CPAP treatment on endothelial function in patients with mild to moderate obstructive sleep apnea. Reviewed

4. Miyata S, Noda A, Yasuda Y, Kojima MS, Tsukano S, Sugiura T, Koike Y, Otake H

Cardiovasc Disord Med Vol. 2 page： 1-4 2017.5

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Reviewed

5. Fujishiro H, Okuda M, Iwamoto K, Miyata S, Otake H, Noda A, Iritani S, Ozaki N

Int J Geriatr Psychiatry Vol. 32 page： 397-406 2017.4

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series

Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Otake Hironao, Noda Akiko, Iritani Shuji, Ozaki Norio

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Vol. 32 ( 4 ) page： 397-406 2017.4

EFFECTS OF SLEEP DISORDER AND PHYSICAL ACTIVITY ON COGNITIVE FUNCTION IN OLDER ADULTS

Noda A., Miyata S., Iwamoto K., Ozaki N.

SLEEP Vol. 40 page： A314 - A314 2017.4

Influence of sleep duration on cortical oxygenation in elderly individuals

Kato Kazuko, Miyata Seiko, Ando Motoo, Matsuoka Hiroki, Yasuma Fumihiko, Iwamoto Kunihiro, Kawano Naoko, Banno Masahiro, Ozaki Norio, Noda Akiko

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 71 ( 1 ) page： 44-51 2017.1

NODA Akiko, MIYATA Seiko

Japanese Journal of Medical Technology Vol. 66 ( J-STAGE-2 ) page： 95 - 105 2017

第3章睡眠検査.認知症予防のための検査特集第6部その他の検査 Reviewed

野田明子, 宮田聖子

医学検査 Vol. 66 page： 95 - 105 2017

睡眠検査 Reviewed

宮田聖子

医学検査 Vol. 66 page： 95 - 105 2017

Endomyocardial radial strain rate imaging during dobutamine stress echocardiography for the evaluation of contractile reserve in patients with dilated cardiomyopathy Reviewed

Minoshima M, Noda A, Kobayashi M, Miyata S, Hirashiki A, Okumura T, Izawa H, Ishii H, Kondo T, Murohara T

J Clin Ultrasound ( 44 ) page： 555-560 2016.11

Masked hypertension and morning blood pressure surge in patients with obstructive sleep apnea syndrome Reviewed

Miyata S, Noda A, Otake H, Yasuda Y.

J Sleep Disor: Treat Care Vol. 5 page： 1 2016.2

The effect of habitual physical training on left ventricular function during exercise by three-dimensional echocardiography Reviewed

Kojima MS, Noda A, Miyata S, Kojima J, Hara Y, Minoshima M, Matsushita T, Murohara T

Echocardiography Vol. 32 page： 1670-1675 2015.11

Impaired cortical oxygenation is related to mood disturbance resulting from three nights of sleep restriction. Reviewed

Miyata S, Noda A, Iwamoto K, Kawano N, Banno M, Tsuruta Y, Noda Y, Ozaki N.

Sleep Biol Rhythms 2015.7

The effect of habitual physical training on left ventricular function during exercise by three-dimensional echocardiography Reviewed

Kojima MS, Noda A, Miyata S, Kojima J, Hara Y, Minoshima M, Matsushita T, Murohara T

Echocardiography 2015.3

Smoking acutely impaired endothelial function in healthy college students

Miyata Seiko, Noda Akiko, Ito Yuki, Iizuka Ryo, Shimokata Kaoru

ACTA CARDIOLOGICA Vol. 70 ( 3 ) page： 282 - 285 2015

The effects of acute treatment with paroxetine, amitriptyline, and placebo on equilibrium function in healthy subjects: A double-blind crossover trial. Reviewed

Miyata S, Noda A, Iwamoto K, Takahashi M, Hara Y, Kojima J, Iidaka T, Ozaki N.

Int J Psy Clin Pract. Vol. 18 ( 1 ) page： 32-36 2014

Effects of a custom-made pillow on sleep and blood pressure circadian rhythm Reviewed

MiyataS, Noda A

J Hypertens Vol. 3 page： 183 2014

睡眠ポリグラフ検査における心電図モニターの役割

宮田聖子, 野田明子

睡眠医療 Vol. 7 page： 406 - 410 2014

Effects of Aged Garlic Extract on Left Ventricular Diastolic Function and Fibrosis in a Rat Hypertension Model

Hara Yuki, Noda Akiko, Miyata Seiko, Minoshima Makoto, Sugiurai Mari, Kojima Jun, Takeo Masafumi, Furukawa Mayuko, Cheng Xian Wu, Nagata Kohzo, Murohara Toyoaki

EXPERIMENTAL ANIMALS Vol. 62 ( 4 ) page： 305-310 2013.10

Disproportionate change of blood flow between the upper limbs and the lower limbs in healthy young adults during recovery from exercise. Reviewed

Miyata S, Noda A, Nishikimi N, Yamada A, Murohara T, Komori K.

Gazzetta Medica Italiana. Vol. 172 ( 3 ) page： 131-136 2013

Comparison of oxygen desaturation patterns in children and adults with sleep-disordered breathing. Reviewed

Hara Y, Noda A, Miyata S, Otake H, Yasuda Y, Okuda M, Koike Y, Nakata S, Nakashima T.

Am J Otolaryngol. Vol. 34 ( 5 ) page： 537-540 2013

Poor sleep quality impaired cognitive performance in older adults. Reviewed

Miyata S, Noda A, Iwamoto K, Kawano N, Okuda M, Ozaki N.

J Sleep Res Vol. 22 ( 5 ) page： 535-541 2013

Effect of Aged Garlic Extract on Left Ventricular Diastolic Function and Fibrosis in Rats Model of Hypertension. Reviewed

Hara Y, Noda A, Miyata S, Minoshima M, Sugiura M, Kojima J, Otake M, Furukawa M, Cheng XW, Nagata K, Murohara T.

Exp Animal. Vol. 62 page： 305-310 2013

Therapeutic strategies for sleep apnea in patients with hypertension and heart failure Reviewed

Noda A, Miyata S, Yasuda Y

Pulmonary Medicine Vol. 2013 page： 814169 2013

Therapeutic strategies for sleep apnea in hypertension and heart failure. Open Access

Noda A, Miyata S, Yasuda Y

Pulmonary medicine Vol. 2013 page： 814169 2013

心房細動と睡眠呼吸障害

宮田聖子, 野田明子

睡眠医療 Vol. 7 page： 272 - 275 2013

Rapid eye movement (REM) sleep: New research

Noda A.

Rapid Eye Movement Sleep: New Research page： 73-83 2012.3

The effects of the prone position on the physiological function in healthy students. Reviewed

Miyata S, Noda A, Fujii Y, Maekawa A, Okuda M, Nakazaki C, Otake H, Nakata S, Yasuma F, Koike Y, Shimokata K, Nakashima T, Hinohara S.

Open Gen Intern Med J. Vol. 5 page： 9-12 2012

The effects of the prone position on the physiological function in healthy students. Reviewed

Miyata S, Noda A, Fujii Y, Maekawa A, Okuda M, Nakazaki C, Otake H, Nakata S, Yasuma F, Koike Y, Shimokata K, Nakashima T, Hinohara S

Open Gen Intern Med J Vol. 5 page： 9-12 2012

RELATIONSHIP BETWEEN SLEEP DURATION AND CARDIO-ANKLE VASCULAR INDEX IN HEALTHY YOUNG ADULTS

Noda A., Miyata S.

SLEEP Vol. 35 page： A317 - A317 2012

The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic syndrome in an aged Japanese population: Results from the KING Study

Nakatochi Masahiro, Miyata Seiko, Tanimura Daisuke, Izawa Hideo, Asano Hiroyuki, Murase Yosuke, Kato Ryuji, Ichihara Sahoko, Naruse Keiko, Matsubara Tatsuaki, Honda Hiroyuki, Yokota Mitsuhiro

DIABETES RESEARCH AND CLINICAL PRACTICE Vol. 92 ( 3 ) page： e61 - 5 2011.6

Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Open Access

Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M

European journal of human genetics : EJHG Vol. 19 ( 3 ) page： 262 - 9 2011.3

Monitoring sleep-wake rhythm with actigraphy in patients on CPAP therapy. Reviewed

Otake M, Miyata S, Noda A, Koike Y, Hara Y, Sugiura M, Minoshima M, Kojima J, Nakata S, Nakashima T.

Respiration Vol. 82 page： 136-141 2011

Monitoring Sleep-Wake Rhythm with Actigraphy in Patients on Continuous Positive Airway Pressure Therapy Open Access

Otake Masafumi, Miyata Seiko, Noda Akiko, Koike Yasuo, Hara Yuki, Sugiura Mari, Minoshima Makoto, Kojima Jun, Nakata Seiichi, Nakashima Tsutomu

RESPIRATION Vol. 82 ( 2 ) page： 136 - 41 2011

ONE NIGHT SLEEP RESTRICTION IMPAIRS THE CORTICAL OXYGENATION RESPONSES

Miyata S., Noda A., Ito M., Iwamoto K., Ozaki N.

EUROPEAN PSYCHIATRY Vol. 26 page： . 2011

Relation of polymorphisms of the adiponectin gene to components of metabolic syndrome in a population-based study in Japan

Tanimura D., Shibata R., Izawa H., Asano H., Hirashiki A., Miyata S., Nakatochi M., Naruse K., Matsubara T., Yokota M.

EUROPEAN HEART JOURNAL Vol. 31 page： 1006-1006 2010.9

健常成人における熟成にんにくの血管内皮機能へ及ぼす影響

宮田聖子, 野田明子, 永井万由佳, 大嶽正文, 上山純, 古池保雄

日本臨床生理学会雑誌 = Japanese journal of applied physiology Vol. 40 ( 2 ) page： 103 - 108 2010.4

Insufficient sleep impairs driving performance and cognitive function. Reviewed

Miyata S, Noda A, Ozaki N, Hara Y, Minoshima M, Iwamoto K, Takahashi M, Iidaka T, Koike Y

Neurosci Lett Vol. 469 page： 229-233 2010

EFFECT OF SLEEP DISORDER ON CARDIOVASCULAR FUNCTION IN THE ELDERLY

Nakazaki C., Noda A., Yamada S., Miyata S., Koike Y.

SLEEP Vol. 33 page： A353 - A354 2010

SLEEP FRAGMENTATION AND HYPOXIA IMPAIR ENDOTHELIAL FUNCTION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME

Noda A., Miyata S., Nakazaki C., Nakata S., Koike Y.

SLEEP Vol. 33 page： A118 - A118 2010

Sleep and lifestyle habits in morning and evening types of human circadian rhythm. Reviewed

Sukegawa M, Noda A, Morishita Y, Ohi H, Miyata S, Honda K, Maeno N, Ozaki N, Koike Y

Biological Rhythm Research Vol. 40 page： 121-127 2009

Impact of microarousal associated with increased negative esophageal pressure in sleep-disordered breathing. Reviewed

Sukegawa M, Noda A, Yasuda Y, Nakata S, Sugiura T, Miyata S, Honda K, Hasegawa Y, Nakashima T, Koike Y

Sleep Breath Vol. 13 page： 369-373 2009

Aortic Pressure Augmentation as a Marker of Cardiovascular Risk in Obstructive Sleep Apnea Syndrome

NODA Akiko, NAKATA Seiichi, FUKATSU Hiroshi, YASUDA Yoshinari, MIYAO Etsuko, MIYATA Seiko, YASUMA Fumihiko, MUROHARA Toyoaki, YOKOTA Mitsuhiro, KOIKE Yasuo

Hypertens Res Vol. 31 ( 6 ) page： 1109 - 1114 2008.6

Evaluation of left ventricular function in healthy subjects during exercise using three-dimensional echocardiography

SUGIURA Mari, NODA Akiko, GOTOH Yumi, MINOSHIMA Makoto, HARA Yuki, MIYATA Seiko, ITOH Rieko, IINO Shigeo, NAGATA Kohzou, KOIKE Yasuo

Choonpa Igaku Vol. 35 ( 4 ) page： 409 - 414 2008.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Ultrasonics in Medicine

Purpose: Three-dimensional (3D) echocardiography is useful for the accurate evaluation of left ventricular (LV) function, but its reliability during exercise remains unclear. We conducted an investigation to determine whether 3D echocardiography was practicable for evaluating LV function during exercise. Subjects and Methods: We studied 18 healthy subjects (12 males, 6 females: 22.7±1.8 years). All subjects underwent supine bicycle ergometer exercise tests. We compared stroke volume index (SVI, stroke volume / body surface area), cardiac index (CI, cardiac output / body surface area), and LV ejection fraction (LVEF) during exercise using pulsed wave Doppler (PWD) and two-dimensional (2D) and 3D echocardiography. The inter-observer and intra-observer variations were measured repeatedly during exercise. Results: The SVI and CI measured by 3D echocardiography continued to increase during exercise, and these were accompanied by heart rate elevation. The inter-observer and intra-observer variations in LV volume measured by 3D echocardiography were better than those for PWD and 2D echocardiography. We could evaluate the dyssynchrony at maximum exercise using 3D echocardiography. Conclusion: 3D echocardiography is a reproducible tool that could feasibly be used for the evaluation of LV function during exercise.

DOI： 10.3179/jjmu.35.409