Papers - OSAKADA Fumitaka
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Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state.
Watanabe K, Yamano M, Miyamoto J, Ohue-Kitano R, Masujima Y, Sasahara D, Mouri Y, Kono N, Inuki S, Osakada F, Nagaoka K, Aoki J, Sugiura Y, Ohno H, Kondoh E, Kimura I
Cell reports Vol. 44 ( 3 ) page： 115433 2025.3
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Nishimura, M; Kodera, T; Adachi, S; Sato, AY; Takeuchi, RF; Nonaka, H; Hamachi, I; Osakada, F
NEUROSCIENCE RESEARCH Vol. 212 page： 20 - 30 2025.3
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Bridge protein-mediated viral targeting of cells expressing endogenous μ-opioid G protein-coupled receptors in the mouse and monkey brain.
Kamaguchi R, Amemori S, Amemori KI, Osakada F
Neuroscience research 2025.2
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Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats.
Takizawa M, Miyazaki S, Tsuchida H, Nagae M, Seki S, Hirabayashi M, Osakada F, Inoue N, Tsukamura H, Uenoyama Y
The Journal of reproduction and development 2025.1
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Iwata, M; Kawabata, R; Morimoto, N; Takeuchi, RF; Sakaguchi, T; Irie, T; Osakada, F
FRONTIERS IN VIROLOGY Vol. 4 2024.4
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Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention. Reviewed
Mai Takakura, Yu Hong Lam, Reiko Nakagawa, Man Yung Ng, Xinyue Hu, Priyanshu Bhargava, Abdalla G Alia, Yuzhe Gu, Zigao Wang, Takeshi Ota, Yoko Kimura, Nao Morimoto, Fumitaka Osakada, Ah Young Lee, Danny Leung, Tomoyuki Miyashita, Juan Du, Hiroyuki Okuno, Yukinori Hirano
Proceedings of the National Academy of Sciences of the United States of America Vol. 120 ( 36 ) page： e2304851120 2023.8
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Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids
Kodera Tomoki, Takeuchi Ryosuke F., Takahashi Sara, Suzuki Keiichiro, Kassai Hidetoshi, Aiba Atsu, Shiozawa Seiji, Okano Hideyuki, Osakada Fumitaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 657 page： 119 - 127 2023.5
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Generation and Application of Engineered Rabies Viral Vectors for Neural Circuit Research Invited Reviewed
Yamaguchi M*, Iwata M*, Kamaguchi R*, Osakada F
Vectorology for Optogenetics and Chemogenetics page： 51 - 75 2023.2
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[Interdisciplinary approaches to brain organoid biology].
Kodera T, Osakada F
Nihon yakurigaku zasshi. Folia pharmacologica Japonica Vol. 158 ( 1 ) page： 64 - 70 2023
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Fast z-focus controlling and multiplexing strategies for multiplane two-photon imaging of neural dynamics
Ito Kei N., Isobe Keisuke, Osakada Fumitaka
NEUROSCIENCE RESEARCH Vol. 179 page： 15 - 23 2022.6
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Monosynaptic rabies virus tracing from projection-targeted single neurons
Masaki Yuji, Yamaguchi Masahiro, Takeuchi Ryosuke F., Osakada Fumitaka
NEUROSCIENCE RESEARCH Vol. 178 page： 20 - 32 2022.5
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Temporally multiplexed dual-plane imaging of neural activity with four-dimensional precision
Onda Masanari, Takeuchi Ryosuke F., Isobe Keisuke, Suzuki Toshiaki, Masaki Yuji, Morimoto Nao, Osakada Fumitaka
NEUROSCIENCE RESEARCH Vol. 171 page： 9 - 18 2021.10
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Cell type- and layer-specific convergence in core and shell neurons of the dorsal lateral geniculate nucleus
Okigawa Sayumi, Yamaguchi Masahiro, Ito Kei N., Takeuchi Ryosuke F., Morimoto Nao, Osakada Fumitaka
JOURNAL OF COMPARATIVE NEUROLOGY Vol. 529 ( 8 ) page： 2099 - 2124 2021.6
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Efficient and robust induction of retinal pigment epithelium cells by tankyrase inhibition regardless of the differentiation propensity of human induced pluripotent stem cells
Ito Arisa, Ye Ke, Onda Masanari, Morimoto Nao, Osakada Fumitaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 552 page： 66 - 72 2021.5
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Reproducible production and image-based quality evaluation of retinal pigment epithelium sheets from human induced pluripotent stem cells
Ye Ke, Takemoto Yuto, Ito Arisa, Onda Masanari, Morimoto Nao, Mandai Michiko, Takahashi Masayo, Kato Ryuji, Osakada Fumitaka
SCIENTIFIC REPORTS Vol. 10 ( 1 ) page： 14387 2020.9
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Multiplex Neural Circuit Tracing With G-Deleted Rabies Viral Vectors
Suzuki Toshiaki, Morimoto Nao, Akaike Akinori, Osakada Fumitaka
FRONTIERS IN NEURAL CIRCUITS Vol. 13 page： 77 2020.1
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[Circuit mechanisms of spatial perception and visuomotor integration].
Takeuchi RF, Osakada F
Nihon yakurigaku zasshi. Folia pharmacologica Japonica Vol. 155 ( 2 ) page： 99 - 106 2020
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[Preface].
Osakada F, Sakamoto K
Nihon yakurigaku zasshi. Folia pharmacologica Japonica Vol. 155 ( 2 ) page： 80 2020
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Role of dynamic nuclear deformation on genomic architecture reorganization
Seirin-Lee Sungrim, Osakada Fumitaka, Takeda Junichi, Tashiro Satoshi, Kobayashi Ryo, Yamamoto Takashi, Ochiai Hiroshi
PLOS COMPUTATIONAL BIOLOGY Vol. 15 ( 9 ) page： e1007289 2019.9
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Tracing of Afferent Connections in the Zebrafish Cerebellum Using Recombinant Rabies Virus
Dohaku Ryuji, Yamaguchi Masahiro, Yamamoto Naoyuki, Shimizu Takashi, Osakada Fumitaka, Hibi Masahiko
FRONTIERS IN NEURAL CIRCUITS Vol. 13 page： 30 2019.4
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Intersectional monosynaptic tracing for dissecting subtype-specific organization of GABAergic interneuron inputs
Yetman Michael J., Washburn Eric, Hyun Jung Ho, Osakada Fumitaka, Hayano Yasufumi, Zeng Hongkui, Callaway Edward M., Kwon Hyung-Bae, Taniguchi Hiroki
NATURE NEUROSCIENCE Vol. 22 ( 3 ) page： 492 - + 2019.3
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Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping
Padmanabhan Krishnan, Osakada Fumitaka, Tarabrina Anna, Kizer Erin, Callaway Edward M., Gage Fred H., Sejnowski Terrence J.
FRONTIERS IN NEUROANATOMY Vol. 12 page： 115 2019.1
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[Cell-type-specific targeting strategies for elucidating neural circuits and pathophysiological mechanisms in the marmoset brain].
Hara T, Osakada F
Nihon yakurigaku zasshi. Folia pharmacologica Japonica Vol. 153 ( 5 ) page： 210 - 218 2019
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The Cutting Edge of Retinal Circuit Research
Osakada Fumitaka, Koike Chieko
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN Vol. 138 ( 5 ) page： 667 - 668 2018.5
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Viral and Electrophysiological Approaches for Elucidating the Structure and Function of Retinal Circuits
Onda Masanari, Sansawa Kouki, Osakada Fumitaka
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN Vol. 138 ( 5 ) page： 669 - 678 2018.5
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[The Cutting Edge of Retinal Circuit Research].
Osakada F, Koike C
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Vol. 138 ( 5 ) page： 667 - 668 2018
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[Viral and Electrophysiological Approaches for Elucidating the Structure and Function of Retinal Circuits].
Onda M, Sansawa K, Osakada F
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Vol. 138 ( 5 ) page： 669 - 678 2018
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Development of Cellular and Tissue-based Products for Retinal Regenerative Medicine
Osakada Fumitaka
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN Vol. 137 ( 1 ) page： 23 - 29 2017.1
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Development of Cellular and Tissue-based Products for Retinal Regenerative Medicine.
Osakada F
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Vol. 137 ( 1 ) page： 23 - 29 2017
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Toward understanding structure and function of neural circuits in the visual system.
Onda M, Osakada F
Nihon yakurigaku zasshi. Folia pharmacologica Japonica Vol. 149 ( 6 ) page： 274 - 280 2017
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新規手法が切り拓く神経回路研究の新時代
小坂田文隆
化学と生物 Vol. 53 ( 10 ) page： 673-680 2015.9
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神経回路の構造と機能を明らかにする新規G欠損狂犬病ウイルストレーシング法
小坂田文隆
日本薬理学雑誌 Vol. 146 ( 2 ) page： 98-105 (J-STAGE) 2015.8
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A dedicated circuit links direction-selective retinal ganglion cells to the primary visual cortex. Reviewed
Cruz-Martín A, El-Danaf RN, Osakada F, Sriram B, Dhande OS, Nguyen PL, Callaway EM, Ghosh A, Huberman AD
Nature Vol. 507 page： 358-361 2014.3
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Design and generation of recombinant rabies virus vectors. Reviewed
Osakada F, Callaway EM
Nature protocols Vol. 8 page： 1583-1601 2013.8
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Imaging light responses of retinal ganglion cells in the living mouse eye. Reviewed
Yin L, Geng Y, Osakada F, Sharma R, Cetin AH, Callaway EM, Williams DR, Merigan WH
Journal of neurophysiology Vol. 109 page： 2415-2421 2013.5
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iPS細胞を用いた網膜変性疾患の病態解析と創薬研究
小坂田文隆
ファルマシア Vol. 48 ( 9 ) page： 842-846 2012.9
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Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Reviewed
West EL, Gonzalez-Cordero A, Hippert C, Osakada F, Martinez-Barbera JP, Pearson RA, Sowden JC, Takahashi M, Ali RR
Stem cells Vol. 30 ( 7 ) page： 1424-1435 2012.7
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New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits. Reviewed
Osakada F, Mori T, Cetin AH, Marshel JH, Virgen B, Callaway EM
Neuron Vol. 71 ( 4 ) page： 617-631 2011.8
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Neural induction and patterning in mammalian pluripotent stem cells. Reviewed
Osakada F, Takahashi M
CNS & neurological disorders drug targets Vol. 10 page： 419-432 2011.6
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Modeling retinal degeneration using patient-specific induced pluripotent stem cells. Reviewed
Jin ZB, Okamoto S, Osakada F, Homma K, Assawachananont J, Hirami Y, Iwata T, Takahashi M
PloS one Vol. 6 page： e17084 2011.2
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Nuclear reprogramming to treat retinal degenerative diseases Reviewed
Osakada F
Inflammation and Regeneration Vol. 31 page： 33-49 2011.1
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網膜神経細胞死の再生・分化を制御する因子
赤池昭紀, 久米利明, 泉安彦, 小坂田文隆
日本薬理学雑誌 Vol. 135 ( 4 ) page： 142-145 2010.4
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In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. Reviewed
Osakada F, Jin ZB, Hirami Y, Ikeda H, Danjyo T, Watanabe K, Sasai Y, Takahashi M
Journal of cell science Vol. 122 ( 17 ) page： 3169-3179 2009.9
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ヒトES細胞・iPS細胞の分化誘導技術の開発―眼疾患への治療応用の可能性―
小坂田文隆, 高橋政代
iPS細胞の産業的応用技術 page： 169-179 2009.9
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Detection of localized retinal malfunction in retinal degeneration model using a multielectrode array system. Reviewed
Homma K, Osakada F, Hirami Y, Jin ZB, Mandai M, Takahashi M
Journal of neuroscience research Vol. 87 page： 2175-2182 2009.7
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Stepwise differentiation of pluripotent stem cells into retinal cells. Reviewed
Osakada F, Ikeda H, Sasai Y, Takahashi M
Nature protocols Vol. 4 page： 811-824 2009
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ES細胞からの神経分化誘導
小坂田文隆, 高橋政代
培養細胞実験ハンドブック page： 291-296 2008.12
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網膜における幹細胞生物学--発生・再生・エイジング (あゆみ 再生医療とアンチエイジング)
小坂田文隆, 高橋政代
医学のあゆみ Vol. 224 ( 7 ) page： 511-517 2008.2
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Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Reviewed
Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, Akaike A, Sasai Y, Takahashi M
Nature biotechnology Vol. 26 ( 2 ) page： 215-224 2008.2
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成体網膜の再生機構における Wnt シグナルの役割
小坂田文隆, 赤池昭紀, 高橋政代
眼薬理 = Japanese journal of ocular pharmacology Vol. 21 ( 1 ) page： 84-86 2007.8
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ミューラーグリアが網膜を再生する (特集 中枢神経の機能再生--細胞治療と人工臓器)
小坂田文隆
メディカルバイオ Vol. 4 ( 5 ) page： 30-35 2007.7
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幹細胞技術の現状と展望(9)中枢神経系における幹細胞治療--網膜再生をめざして
小坂田文隆, 高橋政代
蛋白質核酸酵素 Vol. 52 ( 5 ) page： 470-477 2007.5
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Wnt signaling promotes regeneration in the retina of adult mammals. Reviewed
Osakada F, Ooto S, Akagi T, Mandai M, Akaike A, Takahashi M
The Journal of neuroscience Vol. 27 page： 4210-4219 2007.4
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Neural conversion of ES cells by an inductive activity on human amniotic membrane matrix. Reviewed
Ueno M, Matsumura M, Watanabe K, Nakamura T, Osakada F, Takahashi M, Kawasaki H, Kinoshita S, Sasai Y
Proceedings of the National Academy of Sciences of the United States of America Vol. 103 ( 25 ) page： 9554-9559 2006.6
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体性幹細胞を用いた網膜再生
小坂田文隆, 高橋政代
実験医学 Vol. 24 ( 2 ) page： 256-264 2006.1
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ビタミンE類縁体の神経保護作用
小坂田文隆, 久米利明, 赤池昭紀
医学のあゆみ Vol. 215 ( 8 ) page： 705-706 2005.11
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Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Reviewed
Ikeda H, Osakada F, Watanabe K, Mizuseki K, Haraguchi T, Miyoshi H, Kamiya D, Honda Y, Sasai N, Yoshimura N, Takahashi M, Sasai Y
Proceedings of the National Academy of Sciences of the United States of America Vol. 102 ( 32 ) page： 11331-11336 2005.8
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Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Reviewed
Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A
Neuropharmacology Vol. 47 page： 904-915 2004.11
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Serofendic acid, a sulfur-containing diterpenoid derived from fetal calf serum, attenuates reactive oxygen species-induced oxidative stress in cultured striatal neurons. Reviewed
Osakada F, Kawato Y, Kume T, Katsuki H, Sugimoto H, Akaike A
The Journal of pharmacology and experimental therapeutics Vol. 311 page： 51-59 2004.10
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Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum. Reviewed
Kume T, Asai N, Nishikawa H, Mano N, Terauchi T, Taguchi R, Shirakawa H, Osakada F, Mori H, Asakawa N, Yonaga M, Nishizawa Y, Sugimoto H, Shimohama S, Katsuki H, Kaneko S, Akaike A
Proceedings of the National Academy of Sciences of the United States of America Vol. 99 ( 5 ) page： 3288-3293 2002.3