研究者詳細 - 久島　周

論文 - 久島　周

分割表示 >> ／全件表示 117 件中 1 - 117 件目

Copy Number Variations and Human Well-Being: Integrating Psychiatric, Physical, and Socioeconomic Perspectives 招待有り査読有り

Itaru Kushima, Masahiro Nakatochi, Norio Ozak

Biological psychiatry 2024年12月

Whole-genome sequencing analysis of Japanese autism spectrum disorder trios 査読有り

Furukawa, S; Kushima, I; Kato, H; Kimura, H; Nawa, Y; Aleksic, B; Banno, M; Yamamoto, M; Uematsu, M; Nagasaki, Y; Ogi, T; Ozaki, N; Ikeda, M

PSYCHIATRY AND CLINICAL NEUROSCIENCES 79 巻 ( 3 ) 頁： 87 - 97 2025年3月

Copy number variations in RNF216 and postsynaptic membrane-associated genes are associated with bipolar disorder: a case-control study in the Japanese population 査読有り

Nakatochi, M; Kushima, I; Aleksic, B; Kimura, H; Kato, H; Inada, T; Torii, Y; Takahashi, N; Yamamoto, M; Iwamoto, K; Nawa, Y; Iritani, S; Iwata, N; Saito, T; Ninomiya, K; Okochi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Fujimoto, M; Miura, K; Ohi, K; Shioiri, T; Kitaichi, K; Itokawa, M; Arai, M; Miyashita, M; Toriumi, K; Takahashi, T; Suzuki, M; Kato, TA; Kanba, S; Horikawa, H; Kasai, K; Ikegame, T; Jinde, S; Kato, T; Kakiuchi, C; Yamagata, B; Nio, S; Kunii, Y; Yabe, H; Okamura, Y; Tadaka, S; Fumihiko, U; Obara, T; Yamamoto, Y; Arioka, Y; Mori, D; Ikeda, M; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 79 巻 ( 1 ) 頁： 12 - 20 2025年1月

Treatment-resistant schizophrenia with 22q11.2 deletion and additional genetic defects 査読有り

Furukawa, S; Arafuka, S; Kato, H; Ogi, T; Ozaki, N; Ikeda, M; Kushima, I

NEUROPSYCHOPHARMACOLOGY REPORTS 44 巻 ( 4 ) 頁： 847 - 851 2024年12月

Generation of induced pluripotent stem cells from a schizophrenia patient with heterozygous 1q21.1 deletion 査読有り

Okumura, H; Hayashi, Y; Arioka, Y; Kushima, I; Mori, D; Ozaki, N

STEM CELL RESEARCH 81 巻 2024年12月

Inconsistent embryo selection across polygenic score methods 査読有り

Namba, S; Akiyama, M; Hamanoue, H; Kato, K; Kawashima, M; Kushima, I; Matsuda, K; Nakatochi, M; Ogishima, S; Sonehara, K; Suzuki, K; Takata, A; Tamiya, G; Tanikawa, C; Yamamoto, K; Yamamoto, N; BioBank Japan Project; Ozaki, N; Okada, Y

NATURE HUMAN BEHAVIOUR 8 巻 ( 12 ) 頁： 2264 - 2267 2024年12月

Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice 査読有り

Mori, D; Ikeda, R; Sawahata, M; Yamaguchi, S; Kodama, A; Hirao, T; Arioka, Y; Okumura, H; Inami, C; Suzuki, T; Hayashi, Y; Kato, H; Nawa, Y; Miyata, S; Kimura, H; Kushima, I; Aleksic, B; Mizoguchi, H; Nagai, T; Nakazawa, T; Hashimoto, R; Kaibuchi, K; Kume, K; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY 14 巻 ( 1 ) 2024年3月

Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction 査読有り

Ishikawa, M; Yamamoto, Y; Wulaer, B; Kunisawa, K; Fujigaki, H; Ando, T; Kimura, H; Kushima, I; Arioka, Y; Torii, Y; Mouri, A; Ozaki, N; Nabeshima, T; Saito, K

FEBS JOURNAL 291 巻 ( 5 ) 頁： 945 - 964 2024年3月

Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case-control study 査読有り

Lo, TY; Kushima, I; Kimura, H; Aleksic, B; Okada, T; Kato, H; Inada, T; Nawa, Y; Torii, Y; Yamamoto, M; Kimura, R; Funabiki, Y; Kosaka, H; Numata, S; Kasai, K; Sasaki, T; Yokoyama, S; Munesue, T; Hashimoto, R; Yasuda, Y; Fujimoto, M; Usami, M; Itokawa, M; Arai, M; Ohi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Yamasue, H; Iwata, N; Ikeda, M; Ozaki, N

Neuropsychopharmacology Reports 44 巻 ( 1 ) 頁： 42 - 50 2024年3月

Mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence 査読有り

Aoi, T; Tanaka, A; Furuhashi, K; Ikeya, M; Shimizu, A; Arioka, Y; Kushima, I; Ozaki, N; Maruyama, S

NAGOYA JOURNAL OF MEDICAL SCIENCE 85 巻 ( 4 ) 頁： 682 - 690 2023年11月

Case reports of two siblings with autism spectrum disorder and 15q13.3 deletions 査読有り

Furukawa, S; Kushima, I; Aleksic, B; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS 43 巻 ( 3 ) 頁： 462 - 466 2023年9月

De novo MCM6 variants in neurodevelopmental disorders: a recognizable phenotype related to zinc binding residues 査読有り

Smits, DJ; Schot, R; Popescu, CA; Dias, KR; Ades, L; Briere, LC; Sweetser, DA; Kushima, I; Aleksic, B; Khan, S; Karageorgou, V; Ordonez, N; Sleutels, FJGT; van der Kaay, DCM; Van Mol, C; Van Esch, H; Bertoli-Avella, AM; Roscioli, T; Mancini, GMS

HUMAN GENETICS 142 巻 ( 7 ) 頁： 949 - 964 2023年7月

Structural aging of human neurons is opposite of the changes in schizophrenia 査読有り

Mizutani, R; Saiga, R; Yamamoto, Y; Uesugi, M; Takeuchi, A; Uesugi, K; Terada, Y; Suzuki, Y; De Andrade, V; De Carlo, F; Takekoshi, S; Inomoto, C; Nakamura, N; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Oshima, K; Itokawa, M; Arai, M

PLOS ONE 18 巻 ( 6 ) 2023年6月

The clinical and molecular spectrum of the KDM6B-related neurodevelopmental disorder 査読有り

Rots, D; Jakub, TE; Keung, C; Lisenka, VELM; Banka, S; Pfundt, R; de Vries, BBA; van Jaarsveld, RH; Hopman, SMJ; van Binsbergen, E; Valenzuela, I; Hempel, M; Bierhals, T; Kortüm, F; Lecoquierre, F; Goldenberg, A; Hertz, JM; Andersen, CB; Kibaek, M; Prijoles, EJ; Stevenson, RE; Everman, DB; Patterson, WG; Meng, LY; Gijavanekar, C; De Dios, K; Lakhani, S; Levy, T; Wagner, M; Wieczorek, D; Benke, PJ; Garcia, MSL; Perrier, R; Sousa, SB; Almeida, PM; Simoes, MJ; Isidor, B; Deb, W; Schmanski, AA; Abdul-Rahman, O; Philippe, C; Bruel, AL; Faivre, L; Vitobello, A; Thauvin, C; Smits, JJ; Garavelli, L; Caraffi, SG; Peluso, F; Davis-Keppen, L; Platt, D; Royer, E; Leeuwen, L; Sinnema, M; Stegmann, APA; Stumpel, CTRM; Tiller, GE; Bosch, DSDLGM; Potgieter, ST; Joss, S; Splitt, M; Holden, S; Prapa, M; Foulds, N; Douzgou, S; Puura, K; Waltes, R; Chiocchetti, AG; Freitag, CM; Satterstrom, FK; De Rubeis, S; Buxbaum, J; Gelb, BD; Branko, A; Kushima, I; Howe, J; Scherer, SW; Arado, A; Baldo, C; Patat, O; Benedicte, D; Lopergolo, D; Santorelli, FM; Haack, TB; Dufke, A; Bertrand, M; Falb, RJ; Riess, A; Krieg, P; Spranger, S; Bedeschi, MF; Iascone, M; Josephi-Taylor, S; Roscioli, T; Buckley, MF; Liebelt, J; Dagli, AI; Aten, E; Hurst, ACE; Hicks, A; Suri, M; Aliu, E; Naik, S; Sidlow, R; Coursimault, J; Nicolas, G; Küpper, H; Petit, F; Ibrahim, V; Top, D; Di Cara, F; Louie, RJ; Stolerman, E; Brunner, HG; Vissers, LELM; Kramer, JM; Kleefstra, T

AMERICAN JOURNAL OF HUMAN GENETICS 110 巻 ( 6 ) 頁： 963 - 978 2023年6月

Clinical characterization of patients with schizophrenia and 16p13.11 duplication: A case series 査読有り

Kimura, H; Kushima, I; Banno, M; Inada, T; Yoshimi, A; Aleksic, B; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS 43 巻 ( 2 ) 頁： 267 - 271 2023年6月

Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems 査読有り

Ito, T; Yoshida, M; Aida, T; Kushima, I; Hiramatsu, Y; Ono, M; Yoshimi, A; Tanaka, K; Ozaki, N; Noda, Y

JOURNAL OF NEUROCHEMISTRY 165 巻 ( 2 ) 頁： 211 - 229 2023年4月

The genetic architecture of schizophrenia: review of large-scale genetic studies 査読有り

Kato, H; Kimura, H; Kushima, I; Takahashi, N; Aleksic, B; Ozaki, N

JOURNAL OF HUMAN GENETICS 68 巻 ( 3 ) 頁： 175 - 182 2023年3月

A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells 査読有り

Ohgidani, M; Kushima, I; Inamine, S; Kyuragi, S; Sagata, N; Nakao, T; Kanba, S; Ozaki, N; Kato, TA

PSYCHIATRY AND CLINICAL NEUROSCIENCES 77 巻 ( 2 ) 頁： 128 - 130 2023年2月

Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: a case series 査読有り

Lo, TY; Kushima, I; Aleksic, B; Yoshimi, A; Someya, T; Watanabe, Y; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 77 巻 ( 1 ) 頁： 57 - 59 2023年1月

X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization 査読有り

Kushima, I; Aleksic, B; Kimura, H; Nakatochi, M; Lo, T; Ikeda, M; Arai, M; Hashimoto, R; Numata, S; Okamura, Y; Obara, T; Inada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 76 巻 ( 12 ) 頁： 667 - 673 2022年12月

Turner syndrome presenting with idiopathic regression: A case report 査読有り

Mizobuchi, K; Kushima, I; Kato, H; Miyajima, M; Kimura, H; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 76 巻 ( 12 ) 頁： 680 - 682 2022年12月

Establishment of induced pluripotent stem cells from a patient with 16p13.11 duplication and VPS13B deletion 査読有り

Okumura, H; Arioka, Y; Kushima, I; Mori, D; Ozaki, N

STEM CELL RESEARCH 64 巻 2022年10月

Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder 査読有り

Kushima, I; Nakatochi, M; Aleksic, B; Okada, T; Kimura, H; Kato, H; Morikawa, M; Inada, T; Ishizuka, K; Torii, Y; Nakamura, Y; Tanaka, S; Imaeda, M; Takahashi, N; Yamamoto, M; Iwamoto, K; Nawa, Y; Ogawa, N; Iritani, S; Hayashi, Y; Lo, TY; Otgonbayar, G; Furuta, S; Iwata, N; Ikeda, M; Saito, T; Ninomiya, K; Okochi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Fujimoto, M; Miura, K; Itokawa, M; Arai, M; Miyashita, M; Toriumi, K; Ohi, K; Shioiri, T; Kitaichi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Sasaki, T; Tochigi, M; Nishimura, F; Yamasue, H; Kuwabara, H; Wakuda, T; Kato, TA; Kanba, S; Horikawa, H; Usami, M; Kodaira, M; Watanabe, K; Yoshikawa, T; Toyota, T; Yokoyama, S; Munesue, T; Kimura, R; Funabiki, Y; Kosaka, H; Jung, MY; Kasai, K; Ikegame, T; Jinde, S; Numata, S; Kinoshita, M; Kato, T; Kakiuchi, C; Yamakawa, K; Suzuki, T; Hashimoto, N; Ishikawa, S; Yamagata, B; Nio, S; Murai, T; Son, S; Kunii, Y; Yabe, H; Inagaki, M; Goto, Y; Okumura, Y; Ito, T; Arioka, Y; Mori, D; Ozaki, N

BIOLOGICAL PSYCHIATRY 92 巻 ( 5 ) 頁： 362 - 374 2022年9月

Contribution of copy number variations to the risk of severe eating disorders 査読有り

Kushima, I; Imaeda, M; Tanaka, S; Kato, H; Oya-Ito, T; Nakatochi, M; Aleksic, B; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 76 巻 ( 9 ) 頁： 423 - 428 2022年9月

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism 招待有り査読有り

Nature Genetics 2022年9月

Case series of four psychiatric patients with copy number variations in the neurexin 1 gene

Kushima, I; Inada, T; Ohi, K; Egawa, J; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS 1 巻 ( 3 ) 2022年9月

Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes 査読有り

Kimura, H; Nakatochi, M; Aleksic, B; Guevara, J; Toyama, M; Hayashi, Y; Kato, H; Kushima, I; Morikawa, M; Ishizuka, K; Okada, T; Tsurusaki, Y; Fujita, A; Miyake, N; Ogi, T; Takata, A; Matsumoto, N; Buxbaum, J; Ozaki, N; Sebat, J

TRANSLATIONAL PSYCHIATRY 12 巻 ( 1 ) 2022年7月

Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype

Yoshikawa, A; Kushima, I; Miyashita, M; Suzuki, K; Iino, K; Toriumi, K; Horiuchi, Y; Kawaji, H; Ozaki, N; Itokawa, M; Arai, M

PLOS ONE 17 巻 ( 7 ) 2022年7月

Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients 査読有り

Nawa, Y; Kushima, I; Aleksic, B; Yamamoto, M; Kimura, H; Banno, M; Hashimoto, R; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 76 巻 ( 7 ) 頁： 338 - 339 2022年7月

Psychiatric patients with a de novo 17q12 deletion: Two case reports 査読有り

Kushima, I; Uematsu, M; Ishizuka, K; Aleksic, B; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 76 巻 ( 7 ) 頁： 345 - 347 2022年7月

Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia

Chen, CH; Cheng, MC; Hu, TM; Ping, LY; Kushima, I; Aleksic, B

PSYCHIATRIC GENETICS 32 巻 ( 3 ) 頁： 125 - 130 2022年6月

Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder

Furuta, S; Aleksic, B; Nawa, Y; Kimura, H; Kushima, I; Ishizuka, K; Kato, H; Toyama, M; Arioka, Y; Mori, D; Morikawa, M; Inada, T; Ozaki, N

NAGOYA JOURNAL OF MEDICAL SCIENCE 84 巻 ( 2 ) 頁： 260 - 268 2022年5月

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial

Yamasue, H; Kojima, M; Kuwabara, H; Kuroda, M; Matsumoto, K; Kanai, C; Inada, N; Owada, K; Ochi, K; Ono, N; Benner, S; Wakuda, T; Kameno, Y; Inoue, J; Harada, T; Tsuchiya, K; Umemura, K; Yamauchi, A; Ogawa, N; Kushima, I; Ozaki, N; Suyama, S; Saito, T; Uemura, Y; Hamada, J; Kano, Y; Honda, N; Kikuchi, S; Seto, M; Tomita, H; Miyoshi, N; Matsumoto, M; Kawaguchi, Y; Kanai, K; Ikeda, M; Nakamura, I; Isomura, S; Hirano, Y; Onitsuka, T; Kosaka, H; Okada, T

BRAIN 145 巻 ( 2 ) 頁： 490 - 499 2022年4月

Case report of a female with bipolar disorder and MBD5 deletion

Kushima, I; Lo, T; Aleksic, B; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 76 巻 ( 4 ) 頁： 127 - 128 2022年4月

Variable psychiatric manifestations in patients with 16p11.2 duplication: a case series of 4 patients. 査読有り

Psychiatry Clin Neurosci. 2022年3月

Variable psychiatric manifestations in patients with 16p11.2 duplication: a case series of 4 patients

Hayashi, Y; Kushima, I; Aleksic, B; Senaha, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 76 巻 ( 3 ) 頁： 86 - 88 2022年3月

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder

Wang, CY; Horigane, S; Wakamori, M; Ueda, S; Kawabata, T; Fujii, H; Kushima, I; Kimura, H; Ishizuka, K; Nakamura, Y; Iwayama, Y; Ikeda, M; Iwata, N; Okada, T; Aleksic, B; Mori, D; Yoshida, T; Bito, H; Yoshikawa, T; Takemoto-Kimura, S; Ozaki, N

TRANSLATIONAL PSYCHIATRY 12 巻 ( 1 ) 2022年2月

Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population

Lo, T; Kushima, I; Aleksic, B; Kato, H; Nawa, Y; Hayashi, Y; Otgonbayar, G; Kimura, H; Arioka, Y; Mori, D; Ozaki, N

INTERNATIONAL REVIEW OF PSYCHIATRY 34 巻 ( 2 ) 頁： 154 - 167 2022年2月

Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with NBEA deletion

Kato, H; Kushima, I; Yoshimi, A; Ishizuka, K; Kimura, H; Aleksic, B; Takahashi, N; Okada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 76 巻 ( 1 ) 頁： 36 - 38 2022年1月

Trends in big data analyses by multicenter collaborative translational research in psychiatry

Onitsuka, T; Hirano, Y; Nemoto, K; Hashimoto, N; Kushima, I; Koshiyama, D; Koeda, M; Takahashi, T; Noda, Y; Matsumoto, J; Miura, K; Nakazawa, T; Hikida, T; Kasai, K; Ozaki, N; Hashimoto, R

PSYCHIATRY AND CLINICAL NEUROSCIENCES 76 巻 ( 1 ) 頁： 1 - 14 2022年1月

Case report of a female with bipolar disorder and MBD5 deletion. 査読有り

Psychiatry Clin Neurosci. 2022年

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. 査読有り

Transl Psychiatry 2022年

Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder 査読有り

Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki

Biological Psychiatry 2022年

Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels

Toyama, M; Takasaki, Y; Branko, A; Kimura, H; Kato, H; Nawa, Y; Kushima, I; Ishizuka, K; Shimamura, T; Ogi, T; Ozaki, N

PLOS ONE 17 巻 ( 5 ) 2022年

AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity

Iino, K; Toriumi, K; Agarie, R; Miyashita, M; Suzuki, K; Horiuchi, Y; Niizato, K; Oshima, K; Imai, A; Nagase, Y; Kushima, I; Koike, S; Ikegame, T; Jinde, S; Nagata, E; Washizuka, S; Miyata, T; Takizawa, S; Hashimoto, R; Kasai, K; Ozaki, N; Itokawa, M; Arai, M

FRONTIERS IN GENETICS 12 巻 2021年12月

Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures

Saiga, R; Uesugi, M; Takeuchi, A; Uesugi, K; Suzuki, Y; Takekoshi, S; Inomoto, C; Nakamura, N; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Oshima, K; Itokawa, M; Arai, M; Mizutani, R

SCIENTIFIC REPORTS 11 巻 ( 1 ) 2021年6月

Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress

Yoshikawa, A; Kushima, I; Miyashita, M; Toriumi, K; Suzuki, K; Horiuchi, Y; Kawaji, H; Takizawa, S; Ozaki, N; Itokawa, M; Arai, M

TRANSLATIONAL PSYCHIATRY 11 巻 ( 1 ) 2021年5月

Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders

Saito, R; Miyoshi, C; Koebis, M; Kushima, I; Nakao, K; Mori, D; Ozaki, N; Funato, H; Yanagisawa, M; Aiba, A

MOLECULAR BRAIN 14 巻 ( 1 ) 2021年4月

Resequencing and association analysis of GAP43 with autism spectrum disorder and schizophrenia in a Japanese population 査読有り

Arta, RK; Watanabe, Y; Inoue, E; Nawa, Y; Morikawa, R; Egawa, J; Kushima, I; Igeta, H; Hoya, S; Sugimoto, A; Tanra, AJ; Ozaki, N; Someya, T

RESEARCH IN AUTISM SPECTRUM DISORDERS 82 巻 2021年4月

Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons 査読有り

Hada, K; Wulaer, B; Nagai, T; Itoh, N; Sawahata, M; Sobue, A; Mizoguchi, H; Mori, D; Kushima, I; Nabeshima, T; Ozaki, N; Yamada, K

MOLECULAR BRAIN 14 巻 ( 1 ) 2021年1月

Structural diverseness of neurons between brain areas and between cases 査読有り

TRANSLATIONAL PSYCHIATRY 11 巻 ( 1 ) 2021年1月

Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies 査読有り

Nakatochi, M; Kushima, I; Ozaki, N

JOURNAL OF HUMAN GENETICS 66 巻 ( 1 ) 頁： 25 - 37 2021年1月

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons 査読有り

Arioka, Y; Shishido, E; Kushima, I; Suzuki, T; Saito, R; Aiba, A; Mori, D; Ozaki, N

EBIOMEDICINE 63 巻 2021年1月

Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder 査読有り

Kato, H; Kushima, I; Mori, D; Yoshimi, A; Aleksic, B; Nawa, Y; Toyama, M; Furuta, S; Yu, YJ; Ishizuka, K; Kimura, H; Arioka, Y; Tsujimura, K; Morikawa, M; Okada, T; Inada, T; Nakatochi, M; Shinjo, K; Kondo, Y; Kaibuchi, K; Funabiki, Y; Kimura, R; Suzuki, T; Yamakawa, K; Ikeda, M; Iwata, N; Takahashi, T; Suzuki, M; Okahisa, Y; Takaki, M; Egawa, J; Someya, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY 10 巻 ( 1 ) 2020年12月

Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice 査読有り

Noda, Y; Uchida, M; Mouri, A; Yamada, S; Goto, S; Kitagaki, S; Mamiya, T; Kushima, I; Arioka, Y; Ozaki, N; Yoshimi, A

EUROPEAN NEUROPSYCHOPHARMACOLOGY 41 巻頁： 92 - 105 2020年12月

Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites 査読有り

Yamamoto, M; Bagarinao, E; Kushima, I; Takahashi, T; Sasabayashi, D; Inada, T; Suzuki, M; Iidaka, T; Ozaki, N

PLOS ONE 15 巻 ( 11 ) 2020年11月

Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility 査読有り

Nawa, Y; Kimura, H; Mori, D; Kato, H; Toyama, M; Furuta, S; Yu, YJ; Ishizuka, K; Kushima, I; Aleksic, B; Arioka, Y; Morikawa, M; Okada, T; Inada, T; Kaibuchi, K; Ikeda, M; Iwata, N; Suzuki, M; Okahisa, Y; Egawa, J; Someya, T; Nishimura, F; Sasaki, T; Ozaki, N

HUMAN GENOME VARIATION 7 巻 ( 1 ) 2020年11月

Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia 査読有り

Ishizuka, K; Yoshida, T; Kawabata, T; Imai, A; Mori, H; Kimura, H; Inada, T; Okahisa, Y; Egawa, J; Usami, M; Kushima, I; Morikawa, M; Okada, T; Ikeda, M; Branko, A; Mori, D; Someya, T; Iwata, N; Ozaki, N

JOURNAL OF NEURODEVELOPMENTAL DISORDERS 12 巻 ( 1 ) 2020年9月

The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study 査読有り

Torii, Y; Iritani, S; Sekiguchi, H; Habuchi, C; Fujishiro, H; Kushima, I; Kawakami, I; Itokawa, M; Arai, M; Hayashida, S; Masaki, K; Kira, J; Kawashima, K; Ozaki, N

SCHIZOPHRENIA RESEARCH 223 巻頁： 356 - 358 2020年9月

Morphological alteration of myelin-oligodendrocytes in a schizophrenic patient with 22q11.2 deletion syndrome: An autopsy study

Torii, Y; Iritani, S; Marui, T; Sekiguchi, H; Habuchi, C; Fujishiro, H; Kushima, I; Oshima, K; Niizato, K; Hayashida, S; Masaki, K; Kira, J; Yoshida, M; Ozaki, N

SCHIZOPHRENIA RESEARCH 223 巻頁： 353 - 355 2020年9月

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial 査読有り

Yamasue, H; Okada, T; Munesue, T; Kuroda, M; Fujioka, T; Uno, Y; Matsumoto, K; Kuwabara, H; Mori, D; Okamoto, Y; Yoshimura, Y; Kawakubo, Y; Arioka, Y; Kojima, M; Yuhi, T; Owada, K; Yassin, W; Kushima, I; Benner, S; Ogawa, N; Eriguchi, Y; Kawano, N; Uemura, Y; Yamamoto, M; Kano, Y; Kasai, K; Higashida, H; Ozaki, N; Kosaka, H

MOLECULAR PSYCHIATRY 25 巻 ( 8 ) 頁： 1849 - 1858 2020年8月

ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk 査読有り

Sekiguchi, M; Sobue, A; Kushima, I; Wang, CY; Arioka, Y; Kato, H; Kodama, A; Kubo, H; Ito, N; Sawahata, M; Hada, K; Ikeda, R; Shinno, M; Mizukoshi, C; Tsujimura, K; Yoshimi, A; Ishizuka, K; Takasaki, Y; Kimura, H; Xing, JR; Yu, YJ; Yamamoto, M; Okada, T; Shishido, E; Inada, T; Nakatochi, M; Takano, T; Kuroda, K; Amano, M; Aleksic, B; Yamomoto, T; Sakuma, T; Aida, T; Tanaka, K; Hashimoto, R; Arai, M; Ikeda, M; Iwata, N; Shimamura, T; Nagai, T; Nabeshima, T; Kaibuchi, K; Yamada, K; Mori, D; Ozaki, N

TRANSLATIONAL PSYCHIATRY 10 巻 ( 1 ) 2020年7月

A recurrentPJA1variant in trigonocephaly and neurodevelopmental disorders 査読有り

Suzuki, T; Suzuki, T; Raveau, M; Miyake, N; Sudo, G; Tsurusaki, Y; Watanabe, T; Sugaya, Y; Tatsukawa, T; Mazaki, E; Shimohata, A; Kushima, I; Aleksic, B; Shiino, T; Toyota, T; Iwayama, Y; Nakaoka, K; Ohmori, I; Sasaki, A; Watanabe, K; Hirose, S; Kaneko, S; Inoue, Y; Yoshikawa, T; Ozaki, N; Kano, M; Shimoji, T; Matsumoto, N; Yamakawa, K

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY 7 巻 ( 7 ) 頁： 1117 - 1131 2020年7月

Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia 査読有り

Sawahata, M; Mori, D; Arioka, Y; Kubo, H; Kushima, I; Kitagawa, K; Sobue, A; Shishido, E; Sekiguchi, M; Kodama, A; Ikeda, R; Aleksic, B; Kimura, H; Ishizuka, K; Nagai, T; Kaibuchi, K; Nabeshima, T; Yamada, K; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 74 巻 ( 5 ) 頁： 318 - 327 2020年5月

Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons 査読有り

Arioka, Y; Shishido, E; Kushima, I; Mori, D; Ozaki, N

SCIENTIFIC REPORTS 10 巻 ( 1 ) 2020年4月

Cutting-edge morphological studies of post-mortem brains of patients with schizophrenia and potential applications of X-ray nanotomography (nano-CT)

Itokawa, M; Oshima, K; Arai, M; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Saiga, R; Mizutani, R

PSYCHIATRY AND CLINICAL NEUROSCIENCES 74 巻 ( 3 ) 頁： 176 - 182 2020年3月

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

Saito, R; Koebis, M; Nagai, T; Shimizu, K; Liao, J; Wulaer, B; Sugaya, Y; Nagahama, K; Uesaka, N; Kushima, I; Mori, D; Maruyama, K; Nakao, K; Kurihara, H; Yamada, K; Kano, M; Fukada, Y; Ozaki, N; Aiba, A

TRANSLATIONAL PSYCHIATRY 10 巻 ( 1 ) 2020年2月

Characterization of a schizophrenia patient with a rare RELN deletion by combining genomic and patient-derived cell analyses

Arioka, Y; Hirata, A; Kushima, I; Aleksic, B; Mori, D; Ozaki, N

SCHIZOPHRENIA RESEARCH 216 巻頁： 511 - 515 2020年2月

Polygenic risk scores in schizophrenia with clinically significant copy number variants

Taniguchi, S; Ninomiya, K; Kushima, I; Saito, T; Shimasaki, A; Sakusabe, T; Momozawa, Y; Kubo, M; Kamatani, Y; Ozaki, N; Ikeda, M; Iwata, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 74 巻 ( 1 ) 頁： 35 - 39 2020年1月

A network of networks approach for modeling interconnected brain tissue-specific networks

Kawakubo, H; Matsui, Y; Kushima, I; Ozaki, N; Shimamura, T

BIOINFORMATICS 35 巻 ( 17 ) 頁： 3092 - 3101 2019年9月

In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of PCDH15 and RELN

Ishii, T; Ishikawa, M; Fujimori, K; Maeda, T; Kushima, I; Arioka, Y; Mori, D; Nakatake, Y; Yamagata, B; Nio, S; Kato, TA; Yang, N; Wernig, M; Kanba, S; Mimura, M; Ozaki, N; Okano, H

ENEURO 6 巻 ( 5 ) 2019年9月

Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect

Ikeda, M; Takahashi, A; Kamatanim, Y; Momozawa, Y; Saito, T; Kondo, K; Shimasaki, A; Kawase, K; Sakusabe, T; Iwayama, Y; Toyota, T; Wakudas, T; Kikuchi, M; Kanahara, N; Yamamori, H; Yasuda, Y; Watanabe, Y; Hoya, S; Aleksic, B; Kushima, I; Arai, H; Takaki, M; Hattori, K; Kurrugi, H; Okahisa, Y; Ohnuma, T; Ozaki, N; Someya, T; Hashimotovs, R; Yoshikawa, T; Kubo, M; Iwata, N

SCHIZOPHRENIA BULLETIN 45 巻 ( 4 ) 頁： 824 - 834 2019年7月

Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism

Owada, K; Okada, T; Munesue, T; Kuroda, M; Fujioka, T; Uno, Y; Matsumoto, K; Kuwabara, H; Mori, D; Okamoto, Y; Yoshimura, Y; Kawakubo, Y; Arioka, Y; Kojima, M; Yuhi, T; Yassin, W; Kushima, I; Benner, S; Ogawa, N; Kawano, N; Eriguchi, Y; Uemura, Y; Yamamoto, M; Kano, Y; Kasai, K; Higashida, H; Ozaki, N; Kosaka, H; Yamasue, H

BRAIN 142 巻頁： 2127 - 2136 2019年7月

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

Yoshimi, A; Yamada, S; Kunimoto, S; Aleksic, B; Hirakawa, A; Ohashi, M; Matsumoto, Y; Hada, K; Itoh, N; Arioka, Y; Kimura, H; Kushima, I; Nakamura, Y; Shiino, T; Mori, D; Tanaka, S; Hamada, S; Noda, Y; Nagai, T; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY 9 巻 2019年4月

Three-dimensional alteration of neurites in schizophrenia

Mizutani, R; Saiga, R; Takeuchi, A; Uesugi, K; Terada, Y; Suzuki, Y; De Andrade, V; De Carlo, F; Takekoshi, S; Inomoto, C; Nakamura, N; Kushima, I; Iritani, S; Ozaki, N; Ide, S; Ikeda, K; Oshima, K; Itokawa, M; Arai, M

TRANSLATIONAL PSYCHIATRY 9 巻 2019年2月

A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY

Kimura, H; Ishizuka, K; Wang, CY; Kushima, I; Morikawa, M; Uno, Y; Okada, T; Inanda, T; Aleksic, B; Mori, D; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY 29 巻頁： S1014 - S1014 2019年

Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability

Kunisawa, K; Shimizu, T; Kushima, I; Aleksic, B; Mori, D; Osanai, Y; Kobayashi, K; Taylor, AM; Bhat, MA; Hayashi, A; Baba, H; Ozaki, N; Ikenaka, K

JOURNAL OF NEUROCHEMISTRY 147 巻 ( 3 ) 頁： 395 - 408 2018年11月

Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia

Ishizuka, K; Kimura, H; Kushima, I; Inada, T; Okahisa, Y; Ikeda, M; Iwata, N; Mori, D; Aleksic, B; Ozaki, N

PSYCHIATRIC GENETICS 28 巻 ( 5 ) 頁： 90 - 93 2018年10月

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights 査読有り

Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Okada, T; Uno, Y; Morikawa, M; Ishizuka, K; Shiino, T; Kimura, H; Arioka, Y; Yoshimi, A; Takasaki, Y; Yu, Y; Nakamura, Y; Yamamoto, M; Iidaka, T; Iritani, S; Inada, T; Ogawa, N; Shishido, E; Torii, Y; Kawano, N; Omura, Y; Yoshikawa, T; Uchiyama, T; Yamamoto, T; Ikeda, M; Hashimoto, R; Yamamori, H; Yasuda, Y; Someya, T; Watanabe, Y; Egawa, J; Nunokawa, A; Itokawa, M; Arai, M; Miyashita, M; Kobori, A; Suzuki, M; Takahashi, T; Usami, M; Kodaira, M; Watanabe, K; Sasaki, T; Kuwabara, H; Tochigi, M; Nishimura, F; Yamasue, H; Eriguchi, Y; Benner, S; Kojima, M; Yassin, W; Munesue, T; Yokoyama, S; Kimura, R; Funabiki, Y; Kosaka, H; Ishitobi, M; Ohmori, T; Numata, S; Yoshikawa, T; Toyota, T; Yamakawa, K; Suzuki, T; Inoue, Y; Nakaoka, K; Goto, YI; Inagaki, M; Hashimoto, N; Kusumi, I; Son, S; Murai, T; Ikegame, T; Okada, N; Kasai, K; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N

CELL REPORTS 24 巻 ( 11 ) 頁： 2838 - 2856 2018年9月

Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia

Yamamoto, M; Kushima, I; Suzuki, R; Branko, A; Kawano, N; Inada, T; Iidaka, T; Ozaki, N

PSYCHIATRY RESEARCH-NEUROIMAGING 278 巻頁： 35 - 41 2018年8月

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

Sobue, A; Kushima, I; Nagai, T; Shan, W; Kohno, T; Aleksic, B; Aoyama, Y; Mori, D; Arioka, Y; Kawano, N; Yamamoto, M; Hattori, M; Nabeshima, T; Yamada, K; Ozaki, N

SCIENTIFIC REPORTS 8 巻 2018年8月

Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient

Arioka, Y; Kushima, I; Mori, D; Ozaki, N

STEM CELL RESEARCH 31 巻頁： 240 - 243 2018年8月

Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant

Arioka, Y; Shishido, E; Kubo, H; Kushima, I; Yoshimi, A; Kimura, H; Ishizuka, K; Aleksic, B; Maeda, T; Ishikawa, M; Kuzumaki, N; Okano, H; Mori, D; Ozaki, N

TRANSLATIONAL PSYCHIATRY 8 巻 2018年7月

Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion

Arioka, Y; Kushima, I; Kubo, H; Mori, D; Ozaki, N

STEM CELL RESEARCH 30 巻頁： 81 - 84 2018年7月

Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion. 査読有り

Arioka Y, Kushima I, Kubo H, Mori D, Ozaki N.

Stem Cell Res. 2018年5月

Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder

Takata, A; Miyake, N; Tsurusaki, Y; Fukai, R; Miyatake, S; Koshimizu, E; Kushima, I; Okada, T; Morikawa, M; Uno, Y; Ishizuka, K; Nakamura, K; Tsujii, M; Yoshikawa, T; Toyota, T; Okamoto, N; Hiraki, Y; Hashimoto, R; Yasuda, Y; Saitoh, S; Ohashi, K; Sakai, Y; Ohga, S; Hara, T; Kato, M; Nakamura, K; Ito, A; Seiwa, C; Shirahata, E; Osaka, H; Matsumoto, A; Takeshita, S; Tohyama, J; Saikusa, T; Matsuishi, T; Nakamura, T; Tsuboi, T; Kato, T; Suzuki, T; Saitsu, H; Nakashima, M; Mizuguchi, T; Tanaka, F; Mori, N; Ozaki, N; Matsumoto, N

CELL REPORTS 22 巻 ( 3 ) 頁： 734 - 747 2018年1月

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

Yu, YJ; Lin, YN; Takasaki, Y; Wang, CY; Kimura, H; Xing, JR; Ishizuka, K; Toyama, M; Kushima, I; Mori, D; Arioka, Y; Uno, Y; Shiino, T; Nakamura, Y; Okada, T; Morikawa, M; Ikeda, M; Iwata, N; Okahisa, Y; Takaki, M; Sakamoto, S; Someya, T; Egawa, J; Usami, M; Kodaira, M; Yoshimi, A; Oya-Ito, T; Aleksic, B; Ohno, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY 8 巻 2018年1月

IDENTIFICATION OF RARE DISRUPTIVE VARIANTS IN VOLTAGE-GATED CHANNEL GENES (CACNA1C, CACNA1D, CACNA1S, CACNA1I) IN JAPANESE SAMPLES OF SCHIZOPHRENIA AND AUTISM SPECTRUM DISORDER USING ION TORRENT PGM PLATFORM

Wang, C; Kimura, H; Xing, J; Ishizuka, K; Kushima, I; Arioka, Y; Yoshimi, A; Nakamura, Y; Shiino, Y; Oya, Y; Takasaki, Y; Aleksic, B; Mori, D; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY 27 巻頁： S341 - S342 2017年10月

MUTATION SCREENING OF THE PCDH15 GENE IN PATIENTS SUFFERING FROM AUTISM SPECTRUM DISORDERS AND SCHIZOPHRENIA

Ishizuka, K; Wang, CY; Kimura, H; Xing, JR; Kushima, I; Arioka, Y; Yoshimi, A; Nakamura, Y; Oya-Ito, T; Takasaki, Y; Uno, Y; Okada, T; Mori, D; Aleksic, B; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY 27 巻頁： S162 - S163 2017年10月

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

Lim, ET; Uddin, M; De Rubeis, S; Chan, Y; Kamumbu, AS; Zhang, XC; D'Gama, AM; Kim, SN; Hill, RS; Goldberg, AP; Poultney, C; Minshew, NJ; Kushima, I; Aleksic, B; Ozaki, N; Parellada, M; Arango, C; Penzol, MJ; Carracedo, A; Kolevzon, A; Hultman, CM; Weiss, LA; Fromer, M; Chiocchetti, AG; Freitag, CM; Church, GM; Scherer, SW; Buxbaum, JD; Walsh, CA

NATURE NEUROSCIENCE 20 巻 ( 9 ) 頁： 1217 - + 2017年9月

A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility

Kimura, H; Fujita, Y; Kawabata, T; Ishizuka, K; Wang, C; Iwayama, Y; Okahisa, Y; Kushima, I; Morikawa, M; Uno, Y; Okada, T; Ikeda, M; Inada, T; Branko, A; Mori, D; Yoshikawa, T; Iwata, N; Nakamura, H; Yamashita, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY 7 巻 2017年8月

Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders

Ishizuka, K; Fujita, Y; Kawabata, T; Kimura, H; Iwayama, Y; Inada, T; Okahisa, Y; Egawa, J; Usami, M; Kushima, I; Uno, Y; Okada, T; Ikeda, M; Aleksic, B; Mori, D; Someya, T; Yoshikawa, T; Iwata, N; Nakamura, H; Yamashita, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY 7 巻 2017年8月

High-resolution copy number variation analysis of schizophrenia in Japan 査読有り

Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N.

Molecular Psychiatry 22 巻 ( 3 ) 頁： 430-440 2017年3月

High-resolution copy number variation analysis of schizophrenia in Japan

Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Shiino, T; Yoshimi, A; Kimura, H; Takasaki, Y; Wang, C; Xing, J; Ishizuka, K; Oya-Ito, T; Nakamura, Y; Arioka, Y; Maeda, T; Yamamoto, M; Yoshida, M; Noma, H; Hamada, S; Morikawa, M; Uno, Y; Okada, T; Iidaka, T; Iritani, S; Yamamoto, T; Miyashita, M; Kobori, A; Arai, M; Itokawa, M; Cheng, MC; Chuang, YA; Chen, CH; Suzuki, M; Takahashi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Watanabe, Y; Nunokawa, A; Someya, T; Ikeda, M; Toyota, T; Yoshikawa, T; Numata, S; Ohmori, T; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N

MOLECULAR PSYCHIATRY 22 巻 ( 3 ) 頁： 430 - 440 2017年3月

Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders. 査読有り

Ishizuka K, Tabata H, Ito H, Kushima I, Noda M, Yoshimi A, Usami M, Watanabe K, Morikawa M, Uno Y, Okada T, Mori D, Aleksic B, Ozaki N, Nagata KI.

J Neurosci Res. 2017年

Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility. 査読有り

Kimura H, Kushima I, Yohimi A, Aleksic B, Ozaki N.

Int J Neuropsychopharmacol. 2017年

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders. 査読有り

Isles AR, Ingason A, Lowther C, Walters J, Gawlick M, Stöber G, Rees E, Martin J, Little RB, Potter H, Georgieva L, Pizzo L, Ozaki N, Aleksic B, Kushima I, Ikeda M, Iwata N, Levinson DF, Gejman PV, Shi J, Sanders AR, Duan J, Willis J, Sisodiya S, Costain G, Werge TM, Degenhardt F, Giegling I, Rujescu D, Hreidarsson SJ, Saemundsen E, Ahn JW, Ogilvie C, Girirajan SD, Stefansson H, Stefansson K, O'Donovan MC, Owen MJ, Bassett A, Kirov G.

PLoS Genet. 12 巻 ( 5 ) 頁： e1005993 2016年5月

Contribution of autosomal rare and de novo variants to sex differences in autism 査読有り国際共著

Mahmoud Koko, F Kyle Satterstrom; Autism Sequencing Consortium; APEX consortium; Varun Warrier, Hilary Martin

Am J Hum Genet 112 巻 ( 3 ) 頁： 599 - 614 2025年3月

Association Analysis of Rare CNTN5 Variants With Autism Spectrum Disorder in a Japanese Population 査読有り

Hadi, AF; Arta, RK; Kushima, I; Egawa, J; Watanabe, Y; Ozaki, N; Someya, T

NEUROPSYCHOPHARMACOLOGY REPORTS 45 巻 ( 1 ) 2025年3月

Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data-Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders 査読有り

Yasuda, Y; Ito, S; Matsumoto, J; Okada, N; Onitsuka, T; Ikeda, M; Kushima, I; Sumiyoshi, C; Fukunaga, M; Nemoto, K; Miura, K; Hashimoto, N; Ohi, K; Takahashi, T; Sasabayashi, D; Koeda, M; Yamamori, H; Fujimoto, M; Takano, H; Hasegawa, N; Narita, H; Yamamoto, M; Tha, KK; Kikuchi, M; Kamishikiryo, T; Itai, E; Okubo, Y; Tateno, A; Nakamura, M; Kubota, M; Igarashi, H; Hirano, Y; Okada, G; Miyata, J; Numata, S; Abe, O; Yoshimura, R; Nakagawa, S; Yamasue, H; Ozaki, N; Kasai, K; Hashimoto, R

NEUROPSYCHOPHARMACOLOGY REPORTS 45 巻 ( 1 ) 2025年3月

Molecular diagnosis of 405 individuals with autism spectrum disorder 査読有り

Miyake, N; Tsurusaki, Y; Fukai, R; Kushima, I; Okamoto, N; Ohashi, K; Nakamura, K; Hashimoto, R; Hiraki, Y; Son, S; Kato, M; Sakai, Y; Osaka, H; Deguchi, K; Matsuishi, T; Takeshita, S; Fattal-Valevski, A; Ekhilevitch, N; Tohyama, J; Yap, P; Keng, WT; Kobayashi, H; Takubo, K; Okada, T; Saitoh, S; Yasuda, Y; Murai, T; Nakamura, K; Ohga, S; Matsumoto, A; Inoue, K; Saikusa, T; Hershkovitz, T; Kobayashi, Y; Morikawa, M; Ito, A; Hara, T; Uno, Y; Seiwa, C; Ishizuka, K; Shirahata, E; Fujita, A; Koshimizu, E; Miyatake, S; Takata, A; Mizuguchi, T; Ozaki, N; Matsumoto, N

EUROPEAN JOURNAL OF HUMAN GENETICS 32 巻 ( 12 ) 頁： 1551 - 1558 2024年12月

Analysis of human neuronal cells carrying ASTN2 deletion associated with psychiatric disorders 査読有り

Hayashi, Y; Okumura, H; Arioka, Y; Kushima, I; Mori, D; Lo, TY; Otgonbayar, G; Kato, H; Nawa, Y; Kimura, H; Aleksic, B; Ozaki, N

TRANSLATIONAL PSYCHIATRY 14 巻 ( 1 ) 2024年6月

Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature 査読有り

Mori, D; Inami, C; Ikeda, R; Sawahata, M; Urata, S; Yamaguchi, ST; Kobayashi, Y; Fujita, K; Arioka, Y; Okumura, H; Kushima, I; Kodama, A; Suzuki, T; Hirao, T; Yoshimi, A; Sobue, A; Ito, T; Noda, Y; Mizoguchi, H; Nagai, T; Kaibuchi, K; Okabe, S; Nishiguchi, K; Kume, K; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY 14 巻 ( 1 ) 2024年5月

Oxytocin-induced increases in cytokines and clinical effect on the core social features of autism: Analyses of RCT datasets 査読有り

Wakuda, T; Benner, S; Uemura, Y; Nishimura, T; Kojima, M; Kuroda, M; Matsumoto, K; Kanai, C; Inada, N; Harada, T; Kameno, Y; Munesue, T; Inoue, J; Umemura, K; Yamauchi, A; Ogawa, N; Kushima, I; Suyama, S; Saito, T; Hamada, J; Kano, Y; Honda, N; Kikuchi, S; Seto, M; Tomita, H; Miyoshi, N; Matsumoto, M; Kawaguchi, Y; Kanai, K; Ikeda, M; Nakamura, I; Isomura, S; Hirano, Y; Onitsuka, T; Ozaki, N; Kosaka, H; Okada, T; Kuwabara, H; Yamasue, H

BRAIN BEHAVIOR AND IMMUNITY 118 巻頁： 398 - 407 2024年5月

Trends in big data analyses by multicenter collaborative translational research in psychiatry. 招待有り査読有り

Psychiatry Clin Neurosci. 2022年1月

Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with NBEA deletion. 査読有り

Psychiatry Clin Neurosci. 2022年1月

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial. 査読有り

Brain 2022年

Psychiatric patients with a de novo 17q12 deletion: two case reports. 査読有り

Kushima I, Uematsu M, Ishizuka K, Aleksic B, Ozaki N.

Psychiatry Clin Neurosci. 2022年

Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia. 査読有り国際共著

Psychiatr Genet. 2022年

Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients. 査読有り

Nawa Y, Kushima I, Aleksic B, Yamamoto M, Kimura H, Banno M, Hashimoto R, Ozaki N.

Psychiatry Clin Neurosci. 2022年

AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity. 査読有り

Front Genet. 2021年12月

Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures. 査読有り

Sci Rep. 2021年6月

Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress. 査読有り

Transl Psychiatry 2021年5月

Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders. 査読有り

Mol Brain. 2021年4月

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial. 査読有り

Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H.

Mol Psychiatry. 2018年6月

Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia. 査読有り

Yamamoto M, Kushima I, Suzuki R, Branko A, Kawano N, Inada T, Iidaka T, Ozaki N.

Psychiatry Res Neuroimaging. 2018年6月

Single-neuron and genetic correlates of autistic behavior in macaque. 査読有り

Yoshida K, Go Y, Kushima I, Toyoda A, Fujiyama A, Imai H, Saito N, Iriki A, Ozaki N, Isoda M.

Sci Adv. 2 巻 ( 9 ) 頁： e1600558 2016年9月

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