Updated on 2021/10/19

写真a

 
TERAKURA Seitaro
 
Organization
Nagoya University Hospital Hematology Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 医学博士 ( 2006.5   名古屋大学 ) 

Research Interests 1

  1. Gene-modified immune-cell therapy

Research Areas 1

  1. Others / Others  / 腫瘍免疫

Current Research Project and SDGs 1

  1. キメラ抗原レセプターを遺伝子導入したリンパ球細胞の作 成方法の至適化

Research History 6

  1. 名古屋大学医学部附属病院 病院助教

    2014.4

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    Country:Japan

  2. 名古屋大学医学部附属病院 医員

    2011.10 - 2014.3

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    Country:Japan

  3. Fred Hutchinson Cancer Research Center, visiting fellow

    2008.9 - 2011.8

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    Country:Japan

  4. 名古屋大学大学院医学系研究科 COE研究員

    2006.6 - 2008.3

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    Country:Japan

  5. 名古屋第一赤十字病院 血液内科

    1999.4 - 2003.3

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    Country:Japan

  6. 名古屋第一赤十字病院 嘱託研修医

    1997.4 - 1999.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2003.4 - 2006.5

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1991.4 - 1997.3

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    Country: Japan

Professional Memberships 3

  1. 日本内科学会

  2. 日本血液学会

  3. 日本造血細胞移植学会

 

Papers 73

  1. Altered effect of killer immunoglobulin-like receptor-ligand mismatch by graft versus host disease prophylaxis in cord blood transplantation

    Yokoyama Hisayuki, Hirayama Masahiro, Takahashi Yoshiyuki, Uchida Naoyuki, Tanaka Masatsugu, Onizuka Makoto, Ozawa Yukiyasu, Onai Daishi, Katsuoka Yuna, Wake Atsushi, Sawa Masashi, Kobayashi Hikaru, Maruyama Yumiko, Ozeki Kazutaka, Kimura Takafumi, Kanda Junya, Fukuda Takahiro, Atsuta Yoshiko, Terakura Seitaro, Morishima Satoko

    BONE MARROW TRANSPLANTATION     2021.9

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  2. Impact of HLA disparity on the risk of overall mortality in patients with grade II-IV acute GVHD on behalf of the HLA Working Group of Japan Society for Hematopoietic Cell Transplantation

    Fuji Shigeo, Hakoda Akitoshi, Kanda Junya, Murata Makoto, Terakura Seitaro, Inamoto Yoshihiro, Uchida Naoyuki, Toya Takashi, Eto Tetsuya, Nakamae Hirohisa, Ikegame Kazuhiro, Tanaka Masatsugu, Kawakita Toshiro, Kondo Tadakazu, Miyamoto Toshihiro, Fukuda Takahiro, Ichinohe Tatsuo, Kimura Takafumi, Atsuta Yoshiko, Shintani Ayumi, Morishima Satoko

    BONE MARROW TRANSPLANTATION     2021.9

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  3. Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells.

    Okuno S, Adachi Y, Terakura S, Julamanee J, Sakai T, Umemura K, Miyao K, Goto T, Murase A, Shimada K, Nishida T, Murata M, Kiyoi H

    Journal of immunology (Baltimore, Md. : 1950)     2021.6

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    Language:English  

    DOI: 10.4049/jimmunol.2000768

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  4. Off-the-shelf bone marrow-derived mesenchymal stem cell treatment for acute graft-versus-host disease: real-world evidence

    Murata Makoto, Terakura Seitaro, Wake Atsushi, Miyao Kotaro, Ikegame Kazuhiro, Uchida Naoyuki, Kataoka Keisuke, Miyamoto Toshihiro, Onizuka Makoto, Eto Tetsuya, Doki Noriko, Ota Shuichi, Sato Maho, Hashii Yoshiko, Ichinohe Tatsuo, Fukuda Takahiro, Atsuta Yoshiko, Okamoto Shinichiro, Teshima Takanori

    BONE MARROW TRANSPLANTATION     2021.5

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  5. Low-dose antithymocyte globulin inhibits chronic graft-versus-host disease in peripheral blood stem cell transplantation from unrelated donors

    Shiratori Souichi, Sugita Junichi, Fuji Shigeo, Aoki Jun, Sawa Masashi, Ozawa Yukiyasu, Hashimoto Daigo, Matsuoka Ken-ichi, Imada Kazunori, Doki Noriko, Ashida Takashi, Ueda Yasunori, Tanaka Masatsugu, Sawayama Yasushi, Ichinohe Tatsuo, Terakura Seitaro, Morishima Satoko, Atsuta Yoshiko, Fukuda Takahiro, Teshima Takanori

    BONE MARROW TRANSPLANTATION     2021.5

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  6. Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival.

    Julamanee J, Terakura S, Umemura K, Adachi Y, Miyao K, Okuno S, Takagi E, Sakai T, Koyama D, Goto T, Hanajiri R, Hudecek M, Steinberger P, Leitner J, Nishida T, Murata M, Kiyoi H

    Molecular therapy : the journal of the American Society of Gene Therapy     2021.5

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    Language:English  

    DOI: 10.1016/j.ymthe.2021.04.038

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  7. Comparison of Transplantation Outcomes after Foscarnet and Ganciclovir Administration as First-Line Anti-Cytomegalovirus Preemptive Therapy

    Miyao Kotaro, Terakura Seitaro, Ozawa Yukiyasu, Sawa Masashi, Kohno Akio, Kasahara Senji, Iida Hiroatsu, Ino Kazuko, Kusumoto Shigeru, Kasai Masanobu, Takami Akiyoshi, Kurahashi Shingo, Kajiguchi Tomohiro, Morishita Takanobu, Nishida Tetsuya, Murata Makoto

    TRANSPLANTATION AND CELLULAR THERAPY   Vol. 27 ( 4 ) page: 342.e1 - 342.e10   2021.4

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  8. Single Cord Blood Transplantation Versus Unmanipulated Haploidentical Transplantation for Adults with Acute Myeloid Leukemia in Complete Remission

    Konuma Takaaki, Kanda Junya, Yamasaki Satoshi, Harada Kaito, Shimomura Yoshimitsu, Terakura Seitaro, Mizuno Shohei, Uchida Naoyuki, Tanaka Masatsugu, Doki Noriko, Ozawa Yukiyasu, Nakamae Hirohisa, Sawa Masashi, Matsuoka Ken-ichi, Morishige Satoshi, Maruyama Yumiko, Ikegame Kazuhiro, Kimura Takafumi, Kanda Yoshinobu, Ichinohe Tatsuo, Atsuta Yoshiko, Yanada Masamitsu

    TRANSPLANTATION AND CELLULAR THERAPY   Vol. 27 ( 4 ) page: 334.e1 - 334.e11   2021.4

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  9. Effect of methotrexate dose in graft-versus-host disease prophylaxis after single-unit cord blood transplantation in adult acute myeloid leukemia

    Terakura Seitaro, Kuwatsuka Yachiyo, Sugita Junichi, Takahashi Satoshi, Ozawa Yukiyasu, Ozeki Kazutaka, Yoshioka Satoshi, Nakamae Hirohisa, Kawakita Toshiro, Sawa Masashi, Morishige Satoshi, Najima Yuho, Katsuoka Yuna, Sakaida Emiko, Kouzai Yasuji, Kimura Takafumi, Ichinohe Tatsuo, Fukuda Takahiro, Atsuta Yoshiko, Murata Makoto, Teshima Takanori

    INTERNATIONAL JOURNAL OF HEMATOLOGY     2021.2

  10. Comparison of immunosuppressant regimens in salvage cord blood transplantation for graft failure after allogeneic hematopoietic stem cell transplantation

    Harada Kaito, Fuji Shigeo, Seo Sachiko, Uchida Naoyuki, Kawakita Toshiro, Yano Shingo, Ozawa Yukiyasu, Yoshioka Satoshi, Onishi Yasushi, Noguchi Yuma, Onizuka Makoto, Matsuhashi Yoshiko, Kimura Takafumi, Ichinohe Tatsuo, Atsuta Yoshiko, Terakura Seitaro, Nakasone Hideki

    BONE MARROW TRANSPLANTATION   Vol. 56 ( 2 ) page: 400 - 410   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-020-00999-9

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  11. A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin

    Nishida Tetsuya, Kobayashi Takeshi, Sawa Masashi, Masuda Shinichi, Shibasaki Yasuhiko, Goto Tatsunori, Fukuhara Noriko, Fujii Nobuharu, Ikegame Kazuhiro, Sugita Junichi, Ikeda Takashi, Kuwatsuka Yachiyo, Suzuki Ritsuro, Najima Yuho, Doki Noriko, Kato Tomonori, Inagaki Yuichiro, Utsu Yoshikazu, Aotsuka Nobuyuki, Masuko Masayoshi, Terakura Seitaro, Onishi Yasushi, Maeda Yoshinobu, Okada Masaya, Teshima Takanori, Murata Makoto

    ANNALS OF HEMATOLOGY     2021.1

  12. Effect of cytomegalovirus reactivation with or without acute graft-versus-host disease on the risk of nonrelapse mortality.

    Akahoshi Y, Kimura SI, Inamoto Y, Seo S, Muranushi H, Shimizu H, Ozawa Y, Tanaka M, Uchida N, Kanda Y, Katayama Y, Shiratori S, Ota S, Matsuoka KI, Onizuka M, Fukuda T, Atsuta Y, Murata M, Terakura S, Nakasone H

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     2020.12

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  13. Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation

    Goto Tatsunori, Murata Makoto, Nishida Tetsuya, Terakura Seitaro, Kamoshita Sonoko, Ishikawa Yuichi, Ushijima Yoko, Adachi Yoshiya, Suzuki Satoshi, Kato Katsuyoshi, Hirakawa Akihiro, Nishiwaki Satoshi, Nishio Nobuhiro, Takahashi Yoshiyuki, Kodera Yoshihisa, Matsushita Tadashi, Kiyoi Hitoshi

    STEM CELLS TRANSLATIONAL MEDICINE     2020.12

  14. Comparison of reduced-intensity/toxicity conditioning regimens for umbilical cord blood transplantation for lymphoid malignancies

    Imahashi Nobuhiko, Terakura Seitaro, Kondo Eisei, Kako Shinichi, Uchida Naoyuki, Kobayashi Hikaru, Inamoto Yoshihiro, Sakai Hitoshi, Tanaka Masatsugu, Ishikawa Jun, Kozai Yasuji, Matsuoka Ken-ichi, Kimura Takafumi, Fukuda Takahiro, Atsuta Yoshiko, Kanda Junya

    BONE MARROW TRANSPLANTATION   Vol. 55 ( 11 ) page: 2098 - 2108   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-020-0905-6

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  15. Safety and efficacy of anti-programmed cell death-1 monoclonal antibodies before and after allogeneic hematopoietic cell transplantation for relapsed or refractory Hodgkin lymphoma: a multicenter retrospective study

    Ito Ayumu, Kim Sung-Won, Matsuoka Ken-ichi, Kawakita Toshiro, Tanaka Takashi, Inamoto Yoshihiro, Toubai Tomomi, Fujiwara Shin-ichiro, Fukaya Masafumi, Kondo Tadakazu, Sugita Junichi, Nara Miho, Katsuoka Yuna, Imai Yosuke, Nakazawa Hideyuki, Kawashima Ichiro, Sakai Rika, Ishii Arata, Onizuka Makoto, Takemura Tomonari, Terakura Seitaro, Iida Hiroatsu, Nakamae Mika, Higuchi Kohei, Tamura Shinobu, Yoshioka Satoshi, Togitani Kazuto, Kawano Noriaki, Suzuki Ritsuro, Suzumiya Junji, Izutsu Koji, Teshima Takanori, Fukuda Takahiro

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 112 ( 5 ) page: 674 - 689   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-020-02960-4

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  16. Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity

    Sakai Toshiyasu, Terakura Seitaro, Miyao Kotaro, Okuno Shingo, Adachi Yoshitaka, Umemura Koji, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Leitner Judith, Steinberger Peter, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

    MOLECULAR THERAPY-ONCOLYTICS   Vol. 18   page: 613 - 622   2020.9

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    DOI: 10.1016/j.omto.2020.08.014

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  17. Updated Comparison of 7/8 HLA Allele-Matched Unrelated Bone Marrow Transplantation and Single-Unit Umbilical Cord Blood Transplantation as Alternative Donors in Adults with Acute Leukemia.

    Miyao K, Terakura S, Kimura F, Konuma T, Miyamura K, Yanada M, Kako S, Morhishima S, Uchida N, Toya T, Ozawa Y, Fukuda T, Tanaka M, Sawa M, Takada S, Yoshida S, Kimura T, Ichinohe T, Atsuta Y, Kanda J, Donor/Source Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation     2020.8

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    DOI: 10.1016/j.bbmt.2020.08.001

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  18. Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells

    Tange Naoyuki, Hayakawa Fumihiko, Yasuda Takahiko, Odaira Koya, Yamamoto Hideyuki, Hirano Daiki, Sakai Toshiyasu, Terakura Seitaro, Tsuzuki Shinobu, Kiyoi Hitoshi

    BIOMEDICINE & PHARMACOTHERAPY   Vol. 128   page: 110330   2020.8

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    DOI: 10.1016/j.biopha.2020.110330

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  19. Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome.

    Terakura S, Nishida T, Sawa M, Kato T, Miyao K, Ozawa Y, Goto T, Kohno A, Ozeki K, Onishi Y, Fukuhara N, Fujii N, Yokoyama H, Kasai M, Iida H, Kanemura N, Endo T, Ago H, Onizuka M, Iyama S, Nawa Y, Nakamae M, Nagata Y, Kurahashi S, Tomiya Y, Yanagisawa A, Suzuki R, Kuwatsuka Y, Atsuta Y, Miyamura K, Murata M, Nagoya Blood and Marrow Transplantation Group.

    Bone marrow transplantation     2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-020-0859-8

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  20. Analysis of glutathione S-transferase and cytochrome P450 gene polymorphism in recipients of dose-adjusted busulfan-cyclophosphamide conditioning

    Terakura Seitaro, Onizuka Makoto, Fukumoto Mariko, Kuwatsuka Yachiyo, Kohno Akio, Ozawa Yukiyasu, Miyamura Koichi, Inagaki Yuichiro, Sawa Masashi, Atsuta Yoshiko, Suzuki Ritsuro, Naoe Tomoki, Morishita Yoshihisa, Murata Makoto

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 111 ( 1 ) page: 84 - 92   2020.1

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    DOI: 10.1007/s12185-019-02741-8

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  21. Prospective Phase 2 Study of Umbilical Cord Blood Transplantation in Adult Acute Leukemia and Myelodysplastic Syndrome

    Terakura Seitaro, Nishida Tetsuya, Sawa Masashi, Kato Tomonori, Miyao Kotaro, Ozawa Yukiyasu, Kohno Akio, Onishi Yasushi, Fukuhara Noriko, Kasai Masanobu, Fujii Nobuharu, Yokoyama Hisayuki, Iida Hiroatsu, Kanemura Nobuhiro, Fujieda Atsushi, Ago Hiroatsu, Tsutsumi Yutaka, Nakamura Fumihiko, Yago Kazuhiro, Moriuchi Yukiyoshi, Ota Shuichi, Ohashi Haruhiko, Yanagisawa Atsumi, Suzuki Ritsuro, Kuwatsuka Yachiyo, Atsuta Yoshiko, Miyamura Koichi, Murata Makoto

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   Vol. 26 ( 1 ) page: 139 - 144   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2019.09.021

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  22. Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation

    Kamoshita Sonoko, Murata Makoto, Koyama Daisuke, Julamanee Jakrawadee, Okuno Shingo, Takagi Erina, Miyao Kotaro, Goto Tatsunori, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 111 ( 1 ) page: 112 - 119   2020.1

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    DOI: 10.1007/s12185-019-02739-2

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  23. Analysis of glutathione S-transferase and cytochrome P450 gene polymorphism in recipients of dose-adjusted busulfan-cyclophosphamide conditioning (vol 74, pg 238, 2019)

    Terakura Seitaro, Onizuka Makoto, Fukumoto Mariko, Kuwatsuka Yachiyo, Kohno Akio, Ozawa Yukiyasu, Miyamura Koichi, Inagaki Yuichiro, Sawa Masashi, Atsuta Yoshiko, Suzuki Ritsuro, Naoe Tomoki, Morishita Yoshihisa, Murata Makoto

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 111 ( 1 ) page: 159 - 160   2020.1

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    DOI: 10.1007/s12185-019-02783-y

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  24. Randomised controlled trial of conditioning regimen for cord blood transplantation for adult myeloid malignancies comparing high-dose cytarabine/cyclophosphamide/total body irradiation with versus without G-CSF priming: G-CONCORD study protocol.

    Terakura S, Konuma T, Tanaka M, Ozawa Y, Onizuka M, Nanno S, Onishi Y, Aotsuka N, Kondo T, Kawakita T, Kato J, Kobayashi T, Nishida T, Yamaguchi T, Kuwatsuka Y, Takahashi S

    BMJ open   Vol. 10 ( 12 ) page: e040467   2020

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    DOI: 10.1136/bmjopen-2020-040467

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  25. Phase I Study of Cord Blood Transplantation with Intra-Bone Marrow Injection of Mesenchymal Stem Cells

    Goto Tatsunori, Murata Makoto, Nishida Tetsuya, Terakura Seitaro, Kamoshita Sonoko, Ishikawa Yuichi, Ushijima Yoko, Adachi Yoshiya, Kato Katsuyoshi, Hirakawa Akihiro, Nishiwaki Satoshi, Nishio Nobuhiro, Takahashi Yoshiyuki, Kodera Yoshihisa, Matsushita Tadashi, Kiyoi Hitoshi

    BLOOD   Vol. 134   2019.11

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    Language:Japanese  

    DOI: 10.1182/blood-2019-122101

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  26. Prospective Evaluation of Alternative Donor from Unrelated Volunteer Donor and Cord Blood in Adult Acute Leukemia and Myelodysplastic Syndrome: No Difference between Unrelated Donor and Cord Blood

    Terakura Seitaro, Nishida Tetsuya, Sawa Masashi, Kato Tomonori, Miyao Kotaro, Ozawa Yukiyasu, Goto Tatsunori, Kohno Akio, Ozeki Kazutaka, Onishi Yasushi, Fukuhara Noriko, Fujii Nobuharu, Yokoyama Hisayuki, Kasai Masanobu, Iida Hiroatsu, Kanemura Nobuhiro, Endo Tomoyuki, Ago Hiroatsu, Onizuka Makoto, Iyama Satoshi, Nawa Yuichiro, Nakamae Mika, Nagata Yasuyuki, Kurahashi Shingo, Tomiya Yasuo, Yanagisawa Atsumi, Suzuki Ritsuro, Kuwatsuka Yachiyo, Atsuta Yoshiko, Miyamura Koichi, Murata Makoto

    BLOOD   Vol. 134   2019.11

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    Language:Japanese  

    DOI: 10.1182/blood-2019-124634

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  27. Enhanced effector responses of regenerated CAR-T cells derived from genome edited iPSCs

    Ueda Tatsuki, Iriguchi Shoichi, Kawai Yohei, Minagawa Atsutaka, Miyoshi Hiroyuki, Terakura Seitaro, Uemura Yasushi, Woltjen Knut, Kodama Yuzo, Seno Hiroshi, Hitoshi Yasumichi, Nakatsura Tetsuya, Tamada Koji, Kaneko Shin

    CANCER RESEARCH   Vol. 79 ( 13 )   2019.7

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    DOI: 10.1158/1538-7445.SABCS18-1432

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  28. Impacts of thymoglobulin in patients with acute leukemia in remission undergoing allogeneic HSCT from different donors.

    Wakamatsu M, Terakura S, Ohashi K, Fukuda T, Ozawa Y, Kanamori H, Sawa M, Uchida N, Ota S, Matsushita A, Kanda Y, Nakamae H, Ichinohe T, Kato K, Murata M, Atsuta Y, Teshima T, GVHD Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    Blood advances   Vol. 3 ( 2 ) page: 105-115   2019.1

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    DOI: 10.1182/bloodadvances.2018025643

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  29. [Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient].

    Harada Y, Murata M, Matsumoto A, Kato D, Yagi T, Yaguchi T, Yoshikawa T, Takeichi T, Akiyama M, Yamaguchi Y, Koyama D, Terakura S, Nishida T, Kiyoi H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 60 ( 12 ) page: 1641-1646   2019

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    DOI: 10.11406/rinketsu.60.1641

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  30. Quantitative Assessment of T Cell Clonotypes in Human Acute Graft-versus-Host Disease Tissues.

    Koyama D, Murata M, Hanajiri R, Akashi T, Okuno S, Kamoshita S, Julamanee J, Takagi E, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation     2018.10

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    DOI: 10.1016/j.bbmt.2018.10.012

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  31. Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia

    Hattori Hikaru, Ishikawa Yuichi, Kawashima Naomi, Akashi Akimi, Yamaguchi Yohei, Harada Yasuhiko, Hirano Daiki, Adachi Yoshiya, Miyao Kotaro, Ushijima Yoko, Terakura Seitaro, Nishida Tetsuya, Matsushita Tadashi, Kiyoi Hitoshi

    PLOS ONE   Vol. 13 ( 10 ) page: e0204850   2018.10

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    DOI: 10.1371/journal.pone.0204850

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  32. Generation of CAR-iPS-T cells expressing CD8 beta

    Ueda Tatsuki, Iriguchi Shoichi, Kawai Yohei, Minagawa Atsutaka, Miyoshi Hiroyuki, Terakura Seitaro, Uemura Yasushi, Woltjen Knut, Kodama Yuzo, Seno Hiroshi, Hitoshi Yasumichi, Nakatsura Tetsuya, Tamada Koji, Kaneko Shin

    CANCER RESEARCH   Vol. 78 ( 13 )   2018.7

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    DOI: 10.1158/1538-7445.AM2018-2550

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  33. Introduction of Genetically Modified CD3 zeta Improves Proliferation and Persistence of Antigen-Specific CTLs

    Miyao Kotaro, Terakura Seitaro, Okuno Shingo, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Sakemura Reona, Koyama Daisuke, Goto Tatsunori, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

    CANCER IMMUNOLOGY RESEARCH   Vol. 6 ( 6 ) page: 733 - 744   2018.6

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    DOI: 10.1158/2326-6066.CIR-17-0538

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  34. Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol

    Goto Tatsunori, Murata Makoto, Terakura Seitaro, Nishida Tetsuya, Adachi Yoshiya, Ushijima Yoko, Shimada Kazuyuki, Ishikawa Yuichi, Hayakawa Fumihiko, Nishio Nobuhiro, Nishiwaki Satoshi, Hirakawa Akihiro, Kato Katsuyoshi, Takahashi Yoshiyuki, Kiyoi Hitoshi

    MEDICINE   Vol. 97 ( 17 ) page: e0449   2018.4

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    DOI: 10.1097/MD.0000000000010449

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  35. High Incidence of Extensive Chronic Gvhd in Patients with the REG3A Rs7588571 Non-GG Genotype

    Murata Makoto, Koyama Daisuke, Hanajiri Ryo, Okuno Shingo, Kamoshita Sonoko, Julamanee Jakrawadee, Takagi Erina, Hirano Daiki, Miyao Kotaro, Sakemura Reona, Goto Tatsunori, Hayakawa Fumihiko, Seto Aika, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   Vol. 24 ( 3 ) page: S192-S193   2018.3

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  36. Intrabone single unit cord blood transplantation for hematological malignancies

    Murata Makoto, Maeda Yoshinobu, Masuko Masayoshi, Fukuhara Noriko, Nishida Tetsuya, Terakura Seitaro, Ishikawa Yuichi, Tanimoto Mitsune, Shibasaki Yasuhiko, Suzuki Ritsuro, Kodera Yoshihisa, Kiyoi Hitoshi, Naoe Tomoki

    CANCER SCIENCE   Vol. 109   page: 757-757   2018.1

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  37. iPSC-based CAR-T therapy targeting for GPC3

    Ueda Tatsuki, Irigchi Shoich, Kawai Youhei, Minagawa Atsutaka, Miyoshi Hiroyuki, Terakura Seitaro, Uemura Yasushi, Woltjen Knut, Kodama Yuzo, Tamada Koji, Nakatsura Tetsuya, Seno Hiroshi, Kaneko Shin

    CANCER SCIENCE   Vol. 109   page: 294-294   2018.1

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  38. [MonoMAC syndrome patient developing myelodysplastic syndrome following persistent EBV infection].

    Yamamoto H, Hattori H, Takagi E, Morishita T, Ishikawa Y, Terakura S, Nishida T, Ito Y, Murata M, Kiyoi H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 59 ( 3 ) page: 315-322   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.11406/rinketsu.59.315

    PubMed

  39. Efficacy and safety of autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia: A study protocol for a multicenter exploratory prospective study (Auto-Ph17 study)

    Nishiwaki Satoshi, Sugiura Isamu, Miyata Yasuhiko, Saito Shigeki, Sawa Masashi, Nishida Tetsuya, Miyamura Koichi, Kuwatsuka Yachiyo, Kohno Akio, Yuge Masaaki, Kasai Masanobu, Iida Hiroatsu, Kurahashi Shingo, Osaki Masahide, Goto Tatsunori, Terakura Seitaro, Murata Makoto, Nishikawa Hiroyoshi, Kiyoi Hitoshi

    MEDICINE   Vol. 96 ( 52 ) page: e9568   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MD.0000000000009568

    Web of Science

    PubMed

  40. The activated conformation of integrin beta(7) is a novel multiple myeloma-specific target for CAR T cell therapy

    Hosen Naoki, Matsunaga Yukiko, Hasegawa Kana, Matsuno Hiroshi, Nakamura Yuki, Makita Mio, Watanabe Kouki, Yoshida Mikako, Satoh Kei, Morimoto Soyoko, Fujiki Fumihiro, Nakajima Hiroko, Nakata Jun, Nishida Sumiyuki, Tsuboi Akihiro, Oka Yoshihiro, Manabe Masahiro, Ichihara Hiroyoshi, Aoyama Yasutaka, Mugitani Atsuko, Nakao Takafumi, Hino Masayuki, Uchibori Ryosuke, Ozawa Keiya, Baba Yoshihiro, Terakura Seitaro, Wada Naoki, Morii Eiichi, Nishimura Junichi, Takeda Kiyoshi, Oji Yusuke, Sugiyama Haruo, Takagi Junichi, Kumanogoh Atsushi

    NATURE MEDICINE   Vol. 23 ( 12 ) page: 1436 - +   2017.12

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  41. The activated conformation of integrin β(7) is a novel multiple myeloma-specific target for CAR T cell therapy. Reviewed

    Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, Terakura S, Wada N, Morii E, Nishimura J, Takeda K, Oji Y, Sugiyama H, Takagi J, Kumanogoh A.

    Nature Medicine   Vol. 23 ( 12 ) page: 1436-1443   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/nm.4431.

  42. High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype. Reviewed

    Koyama D, Murata M, Hanajiri R, Okuno S, Kamoshita S, Julamanee J, Takagi E, Hirano D, Miyao K, Sakemura R, Goto T, Hayakawa F, Seto A, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H.

    PLoS One.   Vol. 12 ( 9 ) page: e0185213   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1371/journal.pone.0185213. eCollection 2017.

  43. Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS. Reviewed

    Tawara I, Kageyama S, Miyahara Y, Fujiwara H, Nishida T, Akatsuka Y, Ikeda H, Tanimoto K, Terakura S, Murata M, Inaguma Y, Masuya M, Inoue N, Kidokoro T, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J, Naoe T, Emi N, Yasukawa M, Katayama N, Shiku H.

      Vol. 130 ( 18 ) page: 1985-1994   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1182/blood-2017-06-791202.

  44. Phase II study of intrabone single unit cord blood transplantation for hematological malignancies. Reviewed

    Murata M, Maeda Y, Masuko M, Onishi Y, Endo T, Terakura S, Ishikawa Y, Iriyama C, Ushijima Y, Goto T, Fujii N, Tanimoto M, Kobayashi H, Shibasaki Y, Fukuhara N, Inamoto Y, Suzuki R, Kodera Y, Matsushita T, Kiyoi H, Naoe T, Nishida T.

    Cancer Science   Vol. 108 ( 8 ) page: 1634-1639   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/cas.13291.

  45. GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia. Reviewed

    Terakura S, Kuwatsuka Y, Yamasaki S, Wake A, Kanda J, Inamoto Y, Mizuta S, Yamaguchi T, Uchida N, Kouzai Y, Aotsuka N, Ogawa H, Kanamori H, Nishiwaki K, Miyakoshi S, Onizuka M, Amano I, Fukuda T, Ichinohe T, Atsuta Y, Murata M, Teshima T.

    Bone Marrow Transplant.   Vol. 52 ( 9 ) page: 1261-1267   2017.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bmt.2017.116.

  46. Increase of bone marrow macrophages and CD8(+) T lymphocytes predict graft failure after allogeneic bone marrow or cord blood transplantation. Reviewed

    Kawashima N, Terakura S, Nishiwaki S, Koyama D, Ozawa Y, Ito M, Miyamura K.

    Bone Marrow Transplant.   Vol. 52 ( 8 ) page: 1164-1170   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/bmt.2017.58.

  47. Impact of T-cell chimerism on relapse after cord blood transplantation for hematological malignancies: Nagoya Blood and Marrow Transplantation Group study

    Yokohata E., Kuwatsuka Y., Ohashi H., Terakura S., Kawashima N., Seto A., Kurahashi S., Ozawa Y., Goto T., Imahashi N., Nishida T., Miyao K., Sakemura R., Kato T., Sawa M., Kohno A., Sao H., Iida H., Kiyoi H., Naoe T., Miyamura K., Murata M.

    BONE MARROW TRANSPLANTATION   Vol. 52 ( 4 ) page: 612-614   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bmt.2016.323

    Web of Science

  48. Malignant lymphoma with cardiac involvement.

    Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 58 ( 3 ) page: 239-242   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.11406/rinketsu.58.239

    PubMed

  49. Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil. Reviewed

    Terakura S, Wake A, Inamoto Y, Murata M, Sakai R, Yamaguchi T, Takahashi S, Uchida N, Onishi Y, Ohashi K, Ozawa Y, Kanamori H, Yamaguchi H, Fukuda T, Ichinohe T, Takanashi M, Atsuta Y, Teshima T.

    Bone Marrow Transplant.     2016.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bmt.2016.255.

  50. Impact of graft-versus-host disease on outcomes after unrelated cord blood transplantation. Reviewed

    Kanda J, Morishima Y, Terakura S, Wake A, Uchida N, Takahashi S, Ono Y, Onishi Y, Kanamori H, Aotsuka N, Ozawa Y, Ogawa H, Sakura T, Ohashi K, Ichinohe T, Kato K, Atsuta Y, Teshima T, Murata M.

    Leukemia.     2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/leu.2016.288.

  51. Programmed Death-Ligand 1 on Antigen-presenting Cells Facilitates the Induction of Antigen-specific Cytotoxic T Lymphocytes: Application to Adoptive T-Cell Immunotherapy. Reviewed

    Goto T, Nishida T, Takagi E, Miyao K, Koyama D, Sakemura R, Hanajiri R, Watanabe K, Imahashi N, Terakura S, Murata M, Kiyoi H.

    J Immunother.     2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CJI.0000000000000136.

  52. A Tet-On Inducible System for Controlling CD19-Chimeric Antigen Receptor Expression upon Drug Administration. Reviewed

    Sakemura R, Terakura S, Watanabe K, Julamanee J, Takagi E, Miyao K, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H.

    Cancer Immunol Res.     2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/2326-6066.CIR-16-0043.

  53. Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection. Reviewed

    Hanajiri R, Murata M, Sugimoto K, Murase M, Sakemura R, Goto T, Watanabe K, Imahashi N, Terakura S, Ohashi H, Akatsuka Y, Kurahashi S, Miyamura K, Kiyoi H, Nishida T, Naoe T.

    Bone Marrow Transplant.   Vol. 50 ( 9 ) page: 1187-1194   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bmt.2015.119.

    PubMed

  54. Cutaneous macrophage infiltration in acute GvHD. Reviewed

    Terakura S, Martin PJ, Shulman HM, Storer BE.

    Bone Marrow Transplant.   Vol. 50 ( 8 ) page: 1135-1137   2015.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bmt.2015.114.

    PubMed

  55. Chimerism status after unrelated donor bone marrow transplantation with fludarabine-melphalan conditioning is affected by the melphalan dose and is predictive of relapse. Reviewed

    Imahashi N, Ohashi H, Terakura S, Miyao K, Sakemura R, Kato T, Sawa M, Yokohata E, Kurahashi S, Ozawa Y, Nishida T, Kiyoi H, Watamoto K, Kohno A, Kasai M, Kato C, Iida H, Naoe T, Miyamura K, Murata M; Nagoya Blood and Marrow Transplantation Group.

    Annals of Hematology   Vol. 94 ( 7 ) page: 1139-1148   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-015-2312-4.

    PubMed

  56. Simple and efficient generation of virus-specific T cells for adoptive therapy using anti-4-1BB antibody. Reviewed

    Imahashi N, Nishida T, Goto T, Terakura S, Watanabe K, Hanajiri R, Sakemura R, Imai M, Kiyoi H, Naoe T, Murata M.

    J Immunother   Vol. 38 ( 2 ) page: 62-70   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  57. Comparison of outcomes of 8/8 and 7/8 allele-matched unrelated BMT and single unit CBT in adults with acute leukemia Reviewed

    Terakura S, Atsuta Y, Tsukada N, Kobayashi T, Tanaka M, Kanda J, Najima Y, Fukuda T, Uchida N, Takahashi S, Nagamura-Inoue T, Morishima Y, Miyamura K; Japan Society for Hematopoietic Cell Transplantation.

    Biol Blood Marrow Transplant.     2015

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2015.10.006.

    PubMed

  58. Target antigen density governs the efficacy of anti-CD20-CD28-CD3 ζ chimeric antigen receptor-modified effector CD8+ T cells. Reviewed

    Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M.

    The Journal of Immunology   Vol. 194 ( 3 ) page: 911-920   2014.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1402346.

    PubMed

  59. Comparison of cord blood transplantation with unrelated bone marrow transplantation in patients older than fifty years. Reviewed

    Tanaka M, Miyamura K, Terakura S, Imai K, Uchida N, Ago H, Sakura T, Eto T, Ohashi K, Fukuda T, Taniguchi S, Mori S, Nagamura-Inoue T, Atsuta Y, Okamoto S.

    Biol Blood Marrow Transplant.   Vol. 21 ( 3 ) page: 517-525   2014.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2014.11.685.

    PubMed

  60. Dexamethasone palmitate ameliorates macrophages-rich graft-versus-host disease by inhibiting macrophage functions. Reviewed

    Nishiwaki S, Nakayama T, Murata M, Nishida T, Terakura S, Saito S, Kato T, Mizuno H, Imahashi N, Seto A, Ozawa Y, Miyamura K, Ito M, Takeshita K, Kato H, Toyokuni S, Nagao K, Ueda R, Naoe T.

    PLoS One     2014.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0096252.

    PubMed

  61. Successful unrelated cord blood transplantation for adult acquired aplastic anemia using reduced intensity conditioning without ATG. Reviewed

    Terakura S, Nishida T, Inamoto Y, Ohashi H, Naoe T, Murata M.

    Immunol Lett.   Vol. 160 ( 1 ) page: 99-101   2014.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.imlet.2014.01.013.

    PubMed

  62. Unrelated cord blood transplantation vs related transplantation with HLA 1-antigen mismatch in the graft-versus-host direction. Reviewed

    Kanda J, Ichinohe T, Kato S, Uchida N, Terakura S, Fukuda T, Hidaka M, Ueda Y, Kondo T, Taniguchi S, Takahashi S, Nagamura-Inoue T, Tanaka J, Atsuta Y, Miyamura K, Kanda Y; Donor/Source Working Group and HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    Leukemia   Vol. 27 ( 2 ) page: 286-294   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/leu.2012.203.

    PubMed

  63. Phase II study of dose-modified busulfan by real-time targeting in allogeneic hematopoietic stem cell transplantation for myeloid malignancy. Reviewed

    Kuwatsuka Y, Kohno A, Terakura S, Saito S, Shimada K, Yasuda T, Inamoto Y, Miyamura K, Sawa M, Murata M, Karasuno T, Taniguchi S, Nagafuji K, Atsuta Y, Suzuki R, Fukumoto M, Naoe T, Morishita Y; Nagoya Blood and Marrow Transplantation Group.

    Cancer Science   Vol. 103 ( 9 ) page: 1688-1694   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1349-7006.2012.02342.x.

    PubMed

  64. Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells. Reviewed

    Terakura S, Yamamoto TN, Gardner RA, Turtle CJ, Jensen MC, Riddell SR.

    Blood   Vol. 119 ( 1 ) page: 72-82   2011.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2011-07-366419.

    PubMed

  65. A prospective dose-finding trial using a modified continual reassessment method for optimization of fludarabine plus melphalan conditioning for marrow transplantation from unrelated donors in patients with hematopoietic malignancies. Reviewed

    Terakura S, Atsuta Y, Sawa M, Ohashi H, Kato T, Nishiwaki S, Imahashi N, Yasuda T, Murata M, Miyamura K, Suzuki R, Naoe T, Ito T, Morishita Y; Nagoya Blood and Marrow Transplantation Group.

    Annals of Oncology   Vol. 22 ( 8 ) page: 1865-1871   2011.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/annonc/mdq673.

    PubMed

  66. CTL clones isolated from an HLA-Cw-mismatched bone marrow transplant recipient with acute graft-versus-host disease. Reviewed

    Sugimoto K, Murata M, Terakura S, Naoe T.

    The Journal of Immunology   Vol. 183 ( 9 ) page: 5991-5998   2009.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.0804310.

    PubMed

  67. Impact of macrophage infiltration of skin lesions on survival after allogeneic stem cell transplantation: a clue to refractory graft-versus-host disease. Reviewed

    Nishiwaki S, Terakura S, Ito M, Goto T, Seto A, Watanabe K, Yanagisawa M, Imahashi N, Tsukamoto S, Shimba M, Ozawa Y, Miyamura K.

    Blood   Vol. 114 ( 14 ) page: 3113-3116   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2009-03-209635.

    PubMed

  68. A single minor histocompatibility antigen encoded by UGT2B17 and presented by human leukocyte antigen-A*2902 and -B*4403. Reviewed

    Terakura S, Murata M, Warren EH, Sette A, Sidney J, Naoe T, Riddell SR.

    Transplantation.   Vol. 83 ( 9 ) page: 1242-1248   2007.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  69. Hematopoietic engraftment in recipients of unrelated donor umbilical cord blood is affected by the CD34+ and CD8+ cell doses. Reviewed

    Terakura S, Azuma E, Murata M, Kumamoto T, Hirayama M, Atsuta Y, Kodera Y, Yazaki M, Naoe T, Kato K.

    Biol Blood Marrow Transplant.   Vol. 13 ( 7 ) page: 822-830   2007.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2007.03.006

    PubMed

  70. Short-term methotrexate could reduce early immune reactions and improve outcomes in umbilical cord blood transplantation for adults. Reviewed

    Narimatsu H, Terakura S, Matsuo K, Oba T, Uchida T, Iida H, Hamaguchi M, Watanabe M, Kohno A, Murata M, Sawa M, Miyamura K, Morishita Y.

    Bone Marrow Transplant.   Vol. 39 ( 1 ) page: 31-39   2006.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.bmt.1705539

    PubMed

  71. Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients. Reviewed

    Terakura S, Murata M, Nishida T, Emi N, Akatsuka Y, Morishima Y, Kodera Y, Naoe T.

    Bone Marrow Transplant.   Vol. 37 ( 4 ) page: 381-386   2006.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.bmt.1705257

    PubMed

  72. A UGT2B17-positive donor is a risk factor for higher transplant-related mortality and lower survival after bone marrow transplantation. Reviewed

    Terakura S, Murata M, Nishida T, Emi N, Akatsuka Y, Riddell SR, Morishima Y, Kodera Y, Naoe T.

    Br J Haematol   Vol. 129 ( 2 ) page: 221-228   2005.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2141.2005.05427.x

    PubMed

  73. Intestinal thrombotic microangiopathy after allogeneic bone marrow transplantation: a clinical imitator of acute enteric graft-versus-host disease. Reviewed

    Nishida T, Hamaguchi M, Hirabayashi N, Haneda M, Terakura S, Atsuta Y, Imagama S, Kanie T, Murata M, Taji H, Suzuki R, Morishita Y, Kodera Y.

    Bone Marrow Transplant.   Vol. 33 ( 11 ) page: 1143-1150   2004.4

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    PubMed

▼display all

Presentations 16

  1. A novel strategy of switching on/off CD19CAR expression under Tetracycline based system International conference

    57th ASH Annual Meeting and Exposition 

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    Event date: 2015.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  2. Adoptive transfer of WT1-specific TCR gene-transduced lymphocytes in patients with myelodysplastic syndrome and acute myeloid leukemia. International conference

    Tawara I, Masuya M, Kageyama S, Nishida T, Terakura S, Murata M, Fujiwara H, Akatsuka Y, Ikeda H, Miyahara Y, Tomura D, Nukaya I, Takesako K, Emi N, Yasukawa M, Katayama N, Shiku H.

    57th ASH Annual Meeting and Exposition 

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    Event date: 2015.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  3. Inducible CD19 CAR expression under tetracycline-based regulation system

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  4. 抗原特異的T細胞の誘導における抗原提示細胞に発現するPD-L1の役割

    後藤辰徳、西田徹也、高木えり奈、宮尾康太郎、小山大輔、酒村玲央奈、葉名尻良、渡邊慶介、今橋伸彦、寺倉精太郎、村田誠、清井仁

    第7回血液疾患免疫療法研究会学術集会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  5. 次世代シークエンサーを用いた臍帯血移植片拒絶症例におけるドナー反応性T細胞クローンの追跡

    村田誠、宮尾康太郎、小山大輔、酒村玲央奈、後藤辰徳、渡邊慶介、寺倉精太郎、西田徹也、清井仁

    第7回血液疾患免疫療法研究会学術集会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  6. テトラサイクリンシステムを用いたCD19CARの発現コントロール

    酒村玲央奈、寺倉精太郎、渡邊慶介、宮尾康太郎、小山大輔、後藤辰徳、葉名尻良、西田徹也、村田誠、清井仁

    第7回血液疾患免疫療法研究会学術集会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  7. Critical Effect of scFv Affinity to Chimeric Antigen Receptor Functions

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    Event date: 2015.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  8. Comparison of Outcomes of Unrelated BM and CB transplants in Young Adult Leukemia Patients: An Updated Results of Japanese Registration Data. International conference

    Terakura S, Atsuta Y, Tsukada N, Kobayashi T, Tanaka M, Kanda J, Ohashi K, Fukuda T, Uchida N, Takahashi S, Nagamura-Inoue T, Morishima Y, Miyamura K.

    56th Annual Meeting of American Society of Hematology 

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    Event date: 2014.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  9. Excessively High-Affinity Single-Chain Fragment Variable Region in a Chimeric Antigen Receptor Can Counteract T-cell Proliferation. International conference

    Watanabe K, Terakura S, Uchiyama S, Martens AC, van Meerten T, Nishida T, Naoe T, Kiyoi H, Murata M.

    56th Annual Meeting of American Society of Hematology 

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    Event date: 2014.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  10. Anti-CD20 chimeric antigen receptor+ T cells can recognize remarkably low target antigen expression.

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    Event date: 2014.10 - 2014.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  11. Comparison of unrelated bone marrow and umbilical cord blood transplants in young adult leukemia.

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    Event date: 2014.10 - 2014.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  12. キメラ抗原レセプター遺伝子導入T細胞を用いた細胞治療の今後

    寺倉精太郎

    第63回日本輸血・細胞治療学会東海支部例会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知県、名古屋市、名古屋第一赤十字病院   Country:Japan  

  13. キメラ抗原受容体単鎖抗体部分の強すぎる親和性は抗原刺激後のT細胞増殖を阻害する

    渡邊慶介、 寺倉精太郎、今井美沙、酒村玲央奈、後藤辰徳、葉名尻良、今橋伸彦、島田和之、冨田章裕、西田徹也、村田誠、清井仁

    第6回血液疾患免疫療法研究会学術集会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都府、京都市、京都大学医学部芝蘭会館   Country:Japan  

  14. 新規CD20キメラ抗原レセプター遺伝子導入T細胞の樹立とCD20低発現標的に対する効果の検討

    渡邊慶介、 寺倉精太郎、後藤辰徳、葉名尻良、今橋伸彦、西田徹也、村田誠、直江知樹

    第36回日本造血細胞移植学会 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:沖縄県、宜野湾市   Country:Japan  

  15. 同種臍帯血移植を行い良好な生着・生存を得た成人再生不良性貧血の3例

    寺倉精太郎、後藤辰徳、葉名尻良、渡邊慶介、今橋伸彦、西田徹也、村田誠、直江知樹

    第36回日本造血細胞移植学会 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:沖縄県、宜野湾市   Country:Japan  

  16. Anti-CD20 Chimeric Antigen Receptor Transduced T cells Can Recognize Very Low Antigen Expression: Determination of the Lower Threshold Required to Activate the CAR-T Cells. International conference

    Watanabe K, Terakura S, Goto T, Hanajiri R, Imahashi N, Shimada K, Nishida T, Tomita A, Murata M, Naoe T

    55th Annual Meeting of American Society of Hematology 

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    Event date: 2013.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 3

  1. 小児急性リンパ性白 血病に対する非ウイ ルスベクターを用い たキメラ抗原受容体T 細胞療法の開発

    2015.4 - 2018.3

    厚生労働科学研究委託費・革新的がん医 療実用化研究 

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    Grant type:Competitive

    CD19CAR-T 細胞療法の臨床開発における患者リクルートおよび、新規標的抗原に対するCAR の開発を行う。

  2. 適応拡大に向けた臍帯血移植の先進化による成績向上と普及に関する研究

    2014.4 - 2015.3

    科学技術振興調整費 

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    Grant type:Competitive

    成人血液悪性腫瘍に対する骨髄破壊的前治療後の同種臍帯血移植術の有用性の検討

  3. ヒト化抗CD20抗体を細胞外ドメインとした新規キメラ抗原レセプター (CAR) 遺伝子導入T細胞の作成と評価

    2012.4 - 2014.3

    科学技術振興調整費 

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    Grant type:Competitive

    本研究ではヒト化CD20抗体を細胞外ドメインとして用いたCARを作成・評価し前臨床試験までを行う。既に抗体のAffinityが報告されているヒト化CD20抗体の遺伝子情報を用いるため、すぐに開発に着手できる。ヒト化抗体を用いたCARの開発はまだ報告が少ないが、導入した遺伝子産物に対する免疫反応が起こりにくいと考えられるヒト化抗体を用いて免疫反応を避ける必要性は高い。本研究で用いるCD20抗体はAffinityが既知であるために、標的細胞側の抗原発現量がリガンド結合後のT細胞機能に及ぼす影響を、異なるAffinityのCARを用いて検討可能である。さらにAffinity/avidityを変化させたときにCD28/CD27/4-1BBの細胞内ドメインの違いが及ぼす影響について、とくに抗原刺激後のT細胞の増殖・メモリー化に及ぼす影響についてin vivoで検討する。
    CD20刺激後のサイトカイン分泌や細胞分裂能から最適なCARの構造を決定し、これを用いた臨床試験の準備を行う。

KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. T細胞レセプター遺伝子導入T細胞における細胞内シグナルの増強

    Grant number:18K08351  2018.4 - 2021.3

    寺倉 精太郎

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    NY-ESO-1 TCRとadapter分子(ATAM)を1回の遺伝子導入によりT細胞内に導入可能とする新規ベクターの開発を行った。これを用いて遺伝子導入を行い、NY-ESO-1 TCRとATAMがT細胞に1:1に発現する。この新規ベクターを用いて遺伝子導入を行ったNY-ESO-1特異的TCR-T細胞(以後1virus vector法、1vvと呼ぶ)と、これまで用いていたNY-ESO-1 TCRとATAMを別々の分子として遺伝子導入する方法(以後2virus vector法、2vvと呼ぶ)を比較検討した。
    1vv法を用いても2vv法を用いてもNY-ESO-1 TCRの発現は同様に確認できた。ATAMの細胞表面上の発現量は1vv法と2vv法を比較すると2vv法の方がMFIでは約3倍高かった。蛍光レポーター遺伝子を安定発現するJurkat 細胞(Jurkat TPR細胞)を用いて、1vv法および2vv法にて遺伝子導入を行い、NY-ESO-1抗原刺激を行って、刺激後のシグナル伝達を比較したところ、pERKおよびpJNKともに1vv法で作成したTCR-Tが不良であった。
    ヒト末梢血から分離採取したCD8陽性細胞に上記のようにそれぞれ1vv法および2vv法を用いて遺伝子導入を行い、NY-ESO-1抗原刺激を行った。刺激後の増殖を比較したが、1vv法の方が不良な結果であった。免疫不全マウスにNY-ESO-1抗原陽性細胞株であるMM.1Sを移植し、その後マウスに上記でそれぞれ作成した1vv法由来および2vv法由来のNY-ESO-1 TCR-T細胞を移入したが、治療効果に差は見られなかった。
    ATAMの効果を発揮するためには、TCR分子よりもATAMを多数遺伝子導入できるベクターの開発が必要であることが推測された。そのためATAMを多く遺伝子導入した場合と少なく遺伝子導入した場合のモデルとなる細胞を作成し実験を進めている。
    ATAMの効果を発揮するためには、TCR分子よりもATAMを多数遺伝子導入できるベクターの開発が必要であることが推測された。そのためATAMを多く遺伝子導入した場合と少なく遺伝子導入した場合のモデルとなる細胞を作成し、同様に細胞内シグナルを検討したところ、pERK, pJNKともにATAMが多い場合により強いシグナルが観察された。これまで開発を行なってきた1vv法では1:1でしか発現しないため、十分な効果が出ていないことが考えられた。そのため、現在Dual promoter vectorを用いて、TCRとATAMを別々のpromoterを用いて発現させるvectorを開発している。
    ・現在 二つの別々のpromoterを用いて、独立して二つのタンパクを発現させうるDual promoter vectorを用いて、TCRとATAMを別々のpromoterを用いて発現させるvectorを作成している(2 promoter 法、2pm法)。
    ・これを用いて、TCRとATAMを1回の遺伝子導入で発現させる計画である。その上で、promoter活性によって発現量をATAMが十分発現するように改変することにしている。
    ・2vv法に比較して2pm法でのATAMの発現がどの程度となるのか、ひいてはJurkat TPR細胞を用いた細胞内シグナルの検討や、ヒト末梢血由来リンパ球への遺伝子導入を行って、機能評価を行う。

  2. 新しいコンセプトに基づく変異FLT3に対する標的治療法の開発

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(B)

    清井仁

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    Authorship:Coinvestigator(s) 

    白血病の発症進展において重要な役割を果たす受容体型チロシンキナーゼの変異体に対する抗体およびそれを用いたCAR の開発を行う。

  3. 免疫抑制的腫瘍微小環境を打破する遺伝子導入Tリンパ球の開発とその機能解析

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    腫瘍が醸成する免疫抑制的環境においても細胞傷害活性を発揮する腫瘍特異的免疫担当細胞の作成とその機能解析を行う。
    1.PD-L1に対するchimeric signaling receptor (PD-L1 CSR)の開発および機能解析
    腫瘍微小環境に発現し、腫瘍免疫に対して抑制的な環境を作る分子であるPD-L1 に着目し、その抑制的なシグナルを、逆に免疫に対する賦活化シグナルに変換する方法を開発する。
    2.CTLA-4 knock-out Tリンパ球の開発
    T リンパ球に備わっている自己抑制的メカニズムの中で中心的な役割を果たしているCTLA-4をノックアウトすることによって
    、腫瘍特異的T リンパ球が患者体内で自己抑制的に収縮する
    ことを防ぐ方法を開発する。

  4. Development of transgenic T lymphocytes to break down the immunosuppressive tumor microenvironment and its functional analysis

    Grant number:15K09497  2015.4 - 2018.3

    Terakura Seitaro

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Based on the amino acid sequence information of the antibody against the molecule PD-L1 thought to be expressed on tumor cells in order that tumor cells escape from immune cells, a single-chain antibody binding to PD-L1 was prepared. We further created a novel molecule with CD28 or 4-1BB or both as a part of domain. When this antibody was stained by fluorescent-labeled PD-L1 molecule, it was found that it stained well, indicating that it binds well to the antigen. This gene was transfected into T lymphocytes and its function was examined in vitro and in vivo in mice. On the other hand, we tried to knock out CTLA-4 molecule, which is expressed after activation of T cells and supposedly acts suppressively on self.

  5. キメラ抗原レセプターを遺伝子導入したリンパ球細胞の作 成方法の至適化

    2012.4 - 2015.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

Industrial property rights 2

  1. キメラ抗原レセプター遺伝子発現システム

    寺倉精太郎, 清井仁, 酒村玲央奈

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    Applicant:国立大学法人名古屋大学

    Application no:特願2015-099592  Date applied:2015.5

    Country of applicant:Domestic  

    本発明はキメラ抗原レセプター遺伝子を発現させるためのシステム及びその用途に関する。詳しくは、標的抗原特異的キメラ抗原レセプター遺伝子の発現の制御が可能なシステム及びそれを用いた治療等に関する。

  2. ヒト化抗CD20キメラ抗原レセプター

    寺倉精太郎, 渡邊慶介

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    Applicant:名古屋大学

    Application no:特願2013-234784  Date applied:2013.11

    Country of applicant:Domestic  

    ヒト化CD20抗体を用いて、これをキメラ抗原レセプターとして開発した。

 

Teaching Experience (On-campus) 1

  1. 血液内科

    2015

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