Faculty Profiles - NISHIO Naoki

Papers - NISHIO Naoki

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Laryngeal sensation and pharyngeal delay time after (chemo)radiotherapy. Reviewed International journal

Takashi Maruo, Yasushi Fujimoto, Kikuko Ozawa, Mariko Hiramatsu, Atsushi Suzuki, Naoki Nishio, Tsutomu Nakashima

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery Vol. 271 ( 8 ) page： 2299 - 2304 2014.8

Language：English Publishing type：Research paper (scientific journal)

The objective of the study was to evaluate the association between changes in laryngeal sensation and initiation of swallowing reflex or swallowing function before and after (chemo)radiotherapy. A prospective study was conducted in a tertiary referral university hospital. Thirteen patients who received (chemo)radiotherapy for treatment of laryngeal or hypopharyngeal cancer were included. Laryngeal sensation was evaluated at the tip of the epiglottis before and 1, 3 months, and 1 year after (chemo)radiotherapy. Videofluoroscopy was performed at the same time. Quantitative determinations included changes in laryngeal sensation, computed analysis of pharyngeal delay time, the distance and velocity of hyoid bone movement during the phase of hyoid excursion, and pharyngeal residue rate (the proportion of the bolus that was left as residue in the pharynx at the first swallow). Laryngeal sensation significantly deteriorated 1 month after (chemo)radiotherapy, but there was a tendency to return to pretreatment levels 1 year after treatment. Neither pharyngeal delay time nor displacement of the hyoid bone changed significantly before and after (chemo)radiotherapy. In addition, there was no significant difference in the mean velocity of hyoid bone movement and the amount of stasis in the pharynx at the first swallow before and after (chemo)radiotherapy. After (chemo)radiotherapy, laryngeal sensation deteriorated. But, in this study, videofluoroscopy showed that swallowing reflex and function were maintained.

DOI： 10.1007/s00405-013-2775-7

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PubMed

Inflammatory Pseudotumor of the Infratemporal Fossa Leading to Orbital Apex Syndrome. Reviewed

Nishio N, Fujimoto Y, Nakashima T.

Journal of Craniofacial Surgery Vol. 25 ( 4 ) page： 1324-6 2014.7

Inflammatory pseudotumor of the infratemporal fossa leading to orbital apex syndrome. Reviewed International journal

Naoki Nishio, Yasushi Fujimoto, Tsutomu Nakashima

The Journal of craniofacial surgery Vol. 25 ( 4 ) page： 1324 - 1326 2014.7

Language：English Publishing type：Research paper (scientific journal)

An inflammatory pseudotumor is a rare benign disease presenting with non-specific chronic inflammation, and reported occurrences involving the skull base are relatively rare. A 65-year-old man became aware of pain around the right temporomandibular joint and mild trismus, and palsies of the cranial nerves III, IV, V, and VI were observed. A biopsy was performed under general anesthesia with an infratemporal fossa approach, and he was diagnosed with inflammatory pseudotumor of the infratemporal fossa. There was a rapid improvement in symptoms after the start of steroid administration, and 29 months after the initial consultation, the patient remained under strict observation. The 3 criteria in our department for confirming progression of the disease are (1) clinical symptoms, (2) C-reactive protein levels in blood tests, and (3) contrast effect of the tumor on magnetic resonance imaging. This is a rare case report to demonstrate the inflammatory pseudotumor of the infratemporal fossa leading to orbital apex syndrome.

DOI： 10.1097/SCS.0000000000000789

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PubMed

Effect of clinical symptoms on the indication for selective neck dissection for N0 carcinomas of the parotid gland. Reviewed International journal Open Access

Takashi Maruo, Yasushi Fujimoto, Kenji Yoshida, Mariko Hiramatsu, Atsushi Suzuki, Naoki Nishio, Mariko Shimono, Tsutomu Nakashima

Oncology letters Vol. 8 ( 1 ) page： 335 - 338 2014.7

Language：English Publishing type：Research paper (scientific journal)

Lymph node metastasis is a major prognostic factor in parotid carcinoma, however, the pre-operative diagnosis of occult nodal metastasis is difficult in clinical N0 (cN0) parotid cancer patients. In addition, the indication of neck dissection in T1-3 cN0 patients is controversial. The current study investigated 17 patients with clinical T1-3 cN0 parotid cancer, and analyzed the correlation between patient symptoms/findings and pathological N status/tumor histological grade. In the statistical analysis, pain was found to significantly correlate with neck metastasis. Furthermore, cN0-staged patients without pain exhibited no neck metastasis. However, no significant correlation was identified between patient symptoms or findings and histological grade. These results indicate the possibility that selective neck dissection can be omitted for T1-3 cN0-staged patients without pain.

DOI： 10.3892/ol.2014.2137

Open Access

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PubMed

永久気管孔造設患者におけるNAIM(Nasal Airflow Inducing Maneuver)法を用いた嗅覚改善訓練効果(第2報)

片山直美, 藤本保志, 平松真理子, 丸尾貴志, 西尾直樹, 小出悠介, 須賀研治, 下野真理子, 中田隆文, 曾根三千彦, 中島務

頭頸部癌 Vol. 40 ( 2 ) page： 192 - 192 2014.5

Analysis of post-operative complications and function in patients with cervical esophageal reconstruction using free jejunal flap International journal

Yagi Shunjiro, Toriyama Kazuhiro, Ono Masashi, Fujimoto Yasushi, Hiramatsu Mariko, Maruo Takashi, Nishio Naoki, Kamei Yuzuru

Toukeibu Gan Vol. 40 ( 1 ) page： 1 - 4 2014

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society for Head and Neck Cancer

We reviewed 47 patients who underwent cervical esophageal reconstruction using a free jejunal flap transfer between July 2001 and December 2011. There were 40 males and 7 females with an average age of 64.3. Fifteen patients had radiotherapy preoperatively, and 24 patients postoperatively. The patients who underwent preoperative radiotherapy tended to suffer postoperative complications including surgical site infection and leakage, whereas those who underwent postoperative radiotherapy tended to suffer contracture at the anastomosed site between the free jejunal flap and the esophagus. We consider that free jejunal flap transfer in patients with cervical esophageal cancer is a safe procedure.

DOI： 10.5981/jjhnc.40.1

Scopus

Endothelin-1 gene polymorphism in sudden sensorineural hearing loss. Reviewed International journal

Yasue Uchida, Masaaki Teranishi, Naoki Nishio, Saiko Sugiura, Mariko Hiramatsu, Hidenori Suzuki, Ken Kato, Hironao Otake, Tadao Yoshida, Mitsuhiko Tagaya, Hirokazu Suzuki, Michihiko Sone, Fujiko Ando, Hiroshi Shimokata, Tsutomu Nakashima

The Laryngoscope Vol. 123 ( 11 ) page： E59 - E65 2013.11

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES/HYPOTHESIS: Endothelin-1 is a potent vasoconstrictor peptide that is widely distributed throughout the mammalian body including the spiral modiolar artery, vestibule, and cochlea. This study aimed to investigate the association between the Lys198Asn (G/T) polymorphism (rs5370) of the endothelin-1 gene and sudden sensorineural hearing loss (SSNHL). STUDY DESIGN: Case-control study. METHODS: Seventy-two SSNHL patients (mean age, 58.3 ± 14.0 years) were compared with 2,159 controls included in a community-based study of aging. Multiple logistic regression was used to obtain odds ratios (ORs) for SSNHL. In subgroup analysis, patients with SSNHL who visited to the hospital within the first month of onset were selected to assess audiometric features according to genotype. Pure-tone averages at 250, 500, 1,000, 2,000, and 4,000 Hz were calculated in the affected ear. RESULTS: Under the recessive genetic model, after adjustment for age, sex, histories of hypertension, dyslipidemia and diabetes, the crude and adjusted ORs for SSNHL risk were 2.209 (95% confidence interval [CI]: 1.140-4.281) and 2.173 (95% CI: 1.086-4.348), respectively. No significant ORs were observed under the additive and dominant models. The severity of SSNHL differed significantly between genotypes. The mean pure-tone averages at the initial visit were 78.6, 66.4, and 57.8 dB for the GG, GT, and TT genotypes, respectively (P = .034). CONCLUSIONS: Our study indicates that the recessive genotype was significantly associated with increased SSNHL risk; however, the severity was lower in these individuals than it was in those with the wild-type genotype. Endothelin-1 may be implicated in SSNHL.

DOI： 10.1002/lary.24298

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PubMed

Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Ménière's disease Reviewed International journal

Masaaki Teranishi, Yasue Uchida, Naoki Nishio, Ken Kato, Hironao Otake, Tadao Yoshida, Hirokazu Suzuki, Michihiko Sone, Saiko Sugiura, Fujiko Ando, Hiroshi Shimokata, Tsutomu Nakashima

Free Radical Research Vol. 47 ( 6-7 ) page： 498 - 506 2013.7

Language：English Publishing type：Research paper (scientific journal)

The etiologies of idiopathic sudden sensorineural hearing loss (SSNHL) and Ménière's disease remain unclear. Recently, accumulating evidence has demonstrated that free radicals are related to the pathology of inner ear disease. Because genetic factors may contribute partly to the etiologies of SSNHL and Ménière's disease, we investigated the association between genetic polymorphisms located in genes related to the free-radical process and susceptibility to SSNHL and Ménière's disease. We compared 83 patients affected by SSNHL and 83 patients affected by Ménière's disease with 2048 adults (for SSNHL) and 1946 adults (for Ménière's disease) who participated in the National Institute for Longevity Sciences, Longitudinal Study of Aging. Multiple logistic regression was used to calculate odds ratios (ORs) for SSNHL and Ménière's disease in individuals with polymorphisms in the genes: methionine synthase (MTR
rs1805087)
methionine-synthase reductase (MTRR
rs1801394)
nitric oxide synthase 3 (NOS3
rs1799983)
caveolin 1 (Cav1
rs3840634)
melatonin receptor 1B (MTNR1B
rs1387153)
NAD(P)H oxidase p22(phox) subunit (NADH/NADPHp22phox
rs4673)
and mitochondria 5178 (MT5178
rs28357984). The NOS3 polymorphism was significantly associated with a risk of SSNHL
in addition, the OR for the NOS3 polymorphism and SSNHL risk was 2.108 (CI, 1.343-3.309) with adjustment for age and sex. The Cav1 polymorphism was significantly associated with a risk of Ménière's disease
moreover, the OR for the Cav1 polymorphism and Ménière's disease risk was 1.849 (CI, 1.033-3.310) with adjustment for age and sex. In conclusion, the NOS3 and Cav1 polymorphisms were significantly associated with the risk of SSNHL and Ménière's disease, respectively. © 2013 Informa UK, Ltd.

DOI： 10.3109/10715762.2013.793319

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PubMed

Association between polymorphisms in genes encoding methylenetetrahydrofolate reductase and the risk of Ménière's disease. Reviewed International journal

Yang Huang, Masaaki Teranishi, Yasue Uchida, Naoki Nishio, Ken Kato, Hironao Otake, Tadao Yoshida, Michihiko Sone, Saiko Sugiura, Fujiko Ando, Hiroshi Shimokata, Tsutomu Nakashima

Journal of neurogenetics Vol. 27 ( 1-2 ) page： 5 - 10 2013.6

Language：English Publishing type：Research paper (scientific journal)

Folate metabolism is essential for cellular functioning. Despite extensive research on the roles of folate-metabolism-related gene polymorphisms in the pathophysiology of many diseases, such as cardiovascular disease, cancers, and sudden sensorineural hearing loss, little is known about their association with Ménière's disease (MD). The aim of this study was to investigate the effect of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms (C677T and A1298C) on the risk of MD in a Japanese population. We examined the C677T and A1298C (rs1801133 and rs1801131) polymorphisms in the MTHFR gene and compared them between 1946 adults (986 men and 960 women) participating in the National Institute for Longevity Sciences Longitudinal Study of Aging and 86 cases of MD. A multiple logistic regression was performed to obtain odds ratios (ORs) for the risk of MD regarding the MTHFR polymorphisms before (model 1) and after (model 2) adjustment for age and sex factors. The OR of MTHFR C677T for the risk of MD was 0.669 (95% confidence interval [CI], 0.479-0.934) in model 1 and 0.680 (95% CI, 0.484-0.954) in model 2. In contrast, the OR of MTHFR A1298C for the risk of MD was 1.503 (95% CI, 1.064-2.123) in model 1 and 1.505 (95% CI, 1.045-2.167) in model 2. Our results imply that the MTHFR C677T and A1298C polymorphisms are associated with the risk of MD.

DOI： 10.3109/01677063.2013.770510

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PubMed

Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor α in patients with Ménière's disease and sudden sensorineural hearing loss. Reviewed

Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H, Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.

Life Sciences Vol. 92 ( 10 ) page： 541-6 2013.3

Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Ménière's disease in a Japanese population. Reviewed International journal

Masaaki Teranishi, Yasue Uchida, Naoki Nishio, Ken Kato, Hironao Otake, Tadao Yoshida, Hirokazu Suzuki, Michihiko Sone, Saiko Sugiura, Fujiko Ando, Hiroshi Shimokata, Tsutomu Nakashima

DNA and cell biology Vol. 31 ( 10 ) page： 1555 - 1562 2012.10

Language：English Publishing type：Research paper (scientific journal)

The etiologies of idiopathic sudden sensorineural hearing loss (SSNHL) and Ménière's disease remain unclear. Recently, accumulating evidence has demonstrated that oxidative stress is related to the pathology of inner ear disease. Because genetic factors may contribute partly to the etiologies of SSNHL and Ménière's disease, we investigated the associations between genetic polymorphisms located in oxidative stress response genes and susceptibility to SSNHL and Ménière's disease. We compared 84 patients affected by SSNHL, 82 patients affected by Ménière's disease, and 2107 adults (1056 men and 1051 women; mean age, 59.2 years; range, 40-79 years) who participated in the National Institute for Longevity Sciences, Longitudinal Study of Aging. Multiple logistic regression was used to calculate odds ratios for SSNHL and Ménière's disease in individuals with polymorphisms in the genes glutathione peroxidase 1 (GPX1) (Pro198Leu, rs1050450), paraoxonase 1 (PON1) (Gln192Arg, rs662; and Met55Leu, rs854560), PON2 (Ser311Cys, rs7493), and superoxide dismutase 2 (SOD2) (Val16Ala, rs4880), with adjustment for age and gender. No significant differences in the distribution of the genotypes at these polymorphisms were observed among individuals with SSNHL and Ménière's disease and controls. No significant risk for SSNHL and Ménière's disease was observed in the additive genetic model, regardless of moderating variables. The C allele of SOD2 (rs4880) was more frequent in Ménière's disease cases with a hearing level over 50 dB compared with cases with a hearing level below 50 dB, suggesting that this polymorphism is associated with progression of a hearing loss in Ménière's disease. In conclusion, no significant associations between the polymorphisms of GPX1, PON1, PON2, and SOD2 and risk of SSNHL and Ménière's disease were observed in this Japanese case-control study.

DOI： 10.1089/dna.2012.1631

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PubMed

Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. Reviewed International journal

Mariko Hiramatsu, Masaaki Teranishi, Yasue Uchida, Naoki Nishio, Hidenori Suzuki, Ken Kato, Hironao Otake, Tadao Yoshida, Mitsuhiko Tagaya, Hirokazu Suzuki, Michihiko Sone, Saiko Sugiura, Fujiko Ando, Hiroshi Shimokata, Tsutomu Nakashima

Journal of neurogenetics Vol. 26 ( 3-4 ) page： 387 - 396 2012.9

Language：English Publishing type：Research paper (scientific journal)

Although the etiology of idiopathic sudden sensorineural hearing loss (SSNHL) remains unclear, the pathologically increased permeability of blood vessels, elucidated by gadolinium-enhanced magnetic resonance imaging (MRI), suggests the involvement of inflammation. Because SSNHL is considered a multifactorial disease, possibly caused by interactions between genetic factors and environmental factors, the authors investigated the associations of polymorphisms of inflammatory mediator genes with susceptibility to SSNHL. The authors compared 72 patients affected by SSNHL and 2010 adults (1010 men and 1000 women; mean age 59.2 years; range 40-79) who participated in the National Institute for Longevity Sciences Longitudinal Study of Aging. Multiple logistic regression was used to obtain odds ratios (ORs) for SSNHL in subjects with polymorphisms in the genes IL-6 C - 572G, IL-4R G1902A, IL-10 A - 592C, TNFα C - 863A, TNFRSF1B G593A, VEGF C936T, VEGF C - 2578A, and VEGF G - 1154A, with adjustment for age, gender, and any history of hypertension, diabetes, or dyslipidemia. The per-allele OR for the risk of SSNHL in subjects bearing IL-6 C - 572G was 1.480 (95% confidence interval [CI], 1.037-2.111) in model 1 (no adjustment), 1.463 (CI, 1.022-2.094) in model 2 (adjusted for age and gender), and 1.460 (CI, 1.016-2.097) in model 3 (adjusted for age, gender, and a history of hypertension, diabetes, or dyslipidemia). Under the dominant model of inheritance, the ORs were 1.734 (CI, 1.080-2.783) in model 1, 1.690 (CI, 1.050-2.721) in model 2, and 1.669 (CI, 1.035-2.692) in model 3. The remaining seven polymorphisms failed to show any associations with the risk of SSNHL. These data need to be confirmed on larger series of patients. In conclusion, the IL-6 C - 572G polymorphism is associated with a risk of SSNHL. Because permeability of blood vessels in the inner ear is frequently increased in patients with SSNHL, inflammation of the inner ear might be involved.

DOI： 10.3109/01677063.2011.652266

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PubMed

Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes. Reviewed

Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H, Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.

GENE Vol. 499 ( 1 ) page： 226-30 2012.5

Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Ménière's disease Reviewed International journal

T. Furuta, M. Teranishi, Y. Uchida, N. Nishio, K. Kato, H. Otake, T. Yoshida, M. Tagaya, H. Suzuki, M. Sugiura, M. Sone, M. Hiramatsu, S. Sugiura, F. Ando, H. Shimokata, T. Nakashima

International Journal of Immunogenetics Vol. 38 ( 3 ) page： 249 - 254 2011.6

Language：English Publishing type：Research paper (scientific journal)

Sudden sensorineural hearing loss (SSNHL) and Ménière's disease are the most common inner ear diseases in which the causes are unknown. As recent magnetic resonance imaging has demonstrated disruption of the blood-labyrinth barrier in these inner ear diseases, inflammatory reaction associated with increased permeability of the blood vessels may be involved. The genotypes of interleukin 1A (IL1A) (-889C/T
rs1800587) and interleukin 1B (IL1B) (-511C/T
rs16944) were determined using an allele-specific primer-polymerase chain reaction method in 72 patients with SSNHL, 68 patients with Ménière's disease, and 2202 control subjects living almost in the same area as the patients. A significantly higher prevalence of the IL1A-889T allele was observed in SSNHL and Ménière's disease compared with controls, although no significant difference in distribution of IL1B-511C/T genotypes was observed between the patients and controls. Adjusted odd ratios for SSNHL and Ménière's disease risks in the -889TT genotypes were 25.89 (95% confidence interval (CI) 12.19-54.98) and 18.20 (95% CI 7.80-42.46), respectively, after age and gender were taken as moderator variables. Our results suggested that IL1A is closely associated with susceptibility of SSNHL and Ménière's disease. © 2011 Blackwell Publishing Ltd.

DOI： 10.1111/j.1744-313X.2011.01004.x

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PubMed

Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease. Reviewed International journal

Tsutomu Nakashima, Shinji Naganawa, Masaaki Teranishi, Mitsuhiko Tagaya, Seiichi Nakata, Michihiko Sone, Hironao Otake, Ken Kato, Tomoyuki Iwata, Naoki Nishio

Acta oto-laryngologica Vol. 130 ( 3 ) page： 338 - 343 2010.3

Language：English Publishing type：Research paper (scientific journal)

CONCLUSION: Visualization of endolymphatic hydrops became possible after intravenous gadolinium (Gd) injection in patients with Ménière's disease. OBJECTIVE: To visualize endolymphatic hydrops after intravenous Gd injection. METHODS: Gd (gadoteridol; 0.2 mmol/kg) was injected intravenously in three patients with unilateral Ménière's disease. We performed three-dimensional fluid attenuated inversion recovery (3D-FLAIR) and three-dimensional real inversion recovery (3D-real IR) magnetic resonance imaging (MRI) 4 h after the injection using a 3-Tesla MRI unit. We used a 32-channel array coil to obtain a high signal-to-noise ratio. RESULTS: Endolymphatic hydrops was observed in the ears of patients with Ménière's disease. However, Gd concentration in the perilymph was lower compared with that obtained after intratympanic Gd injection.

DOI： 10.3109/00016480903143986

Web of Science

PubMed

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Papers - NISHIO Naoki