研究者詳細 - 中村　智子

論文 - 中村　智子

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Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture.

Murase T, Iwase A, Komatsu K, Bayasula, Nakamura T, Osuka S, Takikawa S, Goto M, Kotani T, Kikkawa F

Journal of assisted reproduction and genetics 35 巻 ( 2 ) 頁： 339-343 2018年2月

膀胱鏡を併用し腹腔鏡下に膀胱部分切除術を施行した膀胱子宮内膜症の2例

石田千晴, 村岡彩子, 邨瀬智彦, 中村智子, 大須賀智子, 後藤真紀, 野元正崇, 岩瀬明

日本産科婦人科内視鏡学会雑誌 34 巻 ( 2 ) 頁： 204 - 210 2018年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本産科婦人科内視鏡学会

Bladder endometriosis is a rare pelvic dysfunction with painful urination and hematuria. We successfully managed two cases of bladder endometriosis by cystoscopy-assisted laparoscopic partial cystectomy. Case 1: A 40-year-old woman presented with urodynia during menstruation for four years. Cystoscopy revealed a dark-red polypoid lesion on the posterior bladder wall. She underwent hormonal therapy with GnRH-agonist for six months followed by dienogest for a few months. She finally decided to undergo an operation because of poor improvement of symptoms. Incision line was determined using cystoscopy with a margin from both ureteral orifices and then laparoscopic partial cystectomy was performed. She was discharged after confirmation of no leakage by cystography at post-operative day 7. Case 2: A 44-year-old woman was diagnosed with endometriosis at the age of 30 and had been taking low dose estrogen and progestin (LEP). She discontinued LEP owing to breast cancer and then started to feel pain during menstruation, urination, and defecation. Cystoscopy revealed a polypoid lesion on the posterior bladder wall. She underwent laparoscopic hysterectomy, bilateral salpingo-oophorectomy, and cystoscopy-assisted partial cystectomy. Her postoperative course was uneventful, and she was discharged at post-operative day 8. Altogether, this case report suggests that using cystoscopy to avoid unnecessary ureterovesicostomy and maintaining adequate distance from both ureteral orifices is useful to determine the incision line. Cooperation with urologists is necessary when performing surgery in patients with bladder endometriosis.

DOI： 10.5180/jsgoe.34.2_204

CiNii Research

Retrospective analysis of magnetic resonance imaging for differentiating intraligamentous leiomyomas from subserosal leiomyomas

Shimizu, K; Iwase, A; Sakurai, Y; Nakamura, T; Osuka, S; Takikawa, S; Goto, M; Kikkawa, F

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 215 巻頁： 256 - 257 2017年8月

PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF- and TNF- in mononuclear cells by insulin-sensitizing drugs

Yamada-Nomoto, K; Yoshino, O; Akiyama, I; Iwase, A; Ono, Y; Nakamura, T; Harada, M; Nakashima, A; Shima, T; Ushijima, A; Osuga, Y; Chang, RJ; Shimasaki, S; Saito, S

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 78 巻 ( 1 ) 2017年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Journal of Reproductive Immunology

Problem: Plasminogen activator inhibitor-1 (PAI-1) is elevated in women with polycystic ovary syndrome (PCOS), but the regulation in granulosa cells (GCs) is unclear. Method of study: PAI-1 expression in PCOS ovaries was investigated immunohistologically. PAI-1 expressions in HGrC1, a human GC cell line, were investigated at mRNA and activity levels. The expressions of TGF-β and TNF-α in peritoneal fluid mononuclear cells (PFMCs) were measured with quantitative PCR. Results: Little PAI-1 expression is observed in healthy GCs, whereas GCs of PCOS and atretic follicle exhibit distinct expression in vivo. In vitro study using HGrC1 shows that TGF-β and TNF-α increase PAI-1 mRNA and its activity, and both together exhibit a synergistic effect. The expression of PAI-1 mRNA is suppressed by simvastatin. Moreover, insulin-sensitizing drugs (metformin, pioglitazone, and rosiglitazone) suppress LPS-induced TGF-β and TNF-α mRNA expression in PFMC. Conclusion: Statin and insulin-sensitizing drugs may provide a potential therapy for PCOS via down-regulation of PAI-1 expression in GCs and down-regulation of TGF-β and TNF-α expression in PFMC, respectively.

DOI： 10.1111/aji.12669

Web of Science

Scopus

PubMed

Growth Differentiation Factor 9 Induces Granulosa Cell Proliferation via Inhibition of the Expression of AMH Type II Receptor.

Iwase Akira, Osuka Satoko, Bayasula Bayasula, Takikawa Sachiko, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Kikkawa Fumitaka

REPRODUCTIVE SCIENCES 24 巻頁： 163A-163A 2017年3月

Analysis of Follicular Growth and Oocyte Maturation in Cultured Murine Ovarian Tissue.

Murase Tomohiko, Iwase Akira, Nguyen Phuoc Xuan, Ganieva Umida, Qin Ying, Nakanishi Natsuki, Kasahara Yukiyo, Nagai Takashi, Shimizu Ken, Ishida Chiharu, Kato Nao, Osuka Satoko, Nakamura Tomoko, Takikawa Sachiko, Goto Maki, Kikkawa Fumitaka

REPRODUCTIVE SCIENCES 24 巻頁： 292A-292A 2017年3月

Kisspeptin in the Hypothalamus of 2 Rat Models of Polycystic Ovary Syndrome

Osuka, S; Iwase, A; Nakahara, T; Kondo, M; Saito, A; Bayasula; Nakamura, T; Takikawa, S; Goto, M; Kotani, T; Kikkawa, F

ENDOCRINOLOGY 158 巻 ( 2 ) 頁： 367 - 377 2017年2月

CYP51A1 induced by growth differentiation factor 9 and follicle-stimulating hormone in granulosa cells is a possible predictor for unfertilization 査読有り

Nakamura T, Iwase A, Bayasula B, Nagatomo Y, Kondo M, Nakahara T, Takikawa S, Goto M, Kotani T, Kiyono T, Kikkawa F

Reproductive sciences 22 巻 ( 3 ) 頁： 377-84 2015年3月

A Placental Site Trophoblastic Tumor Complicated with Arteriovenous Malformation: A Case Report

Tomoko Nakamura, Akira Iwase, Chiharu Ishida, Sachiko Takikawa, Maki Goto, Fumitaka Kikkawa

Clinical Case Reports 5 巻 ( 9 ) 2015年

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