2021/11/12 更新

写真a

シマムラ テッペイ
島村 徹平
SHIMAMURA Teppei
所属
大学院医学系研究科 附属神経疾患・腫瘍分子医学研究センター 細胞情報統合解析部門 教授
大学院担当
大学院医学系研究科
学部担当
医学部 医学科
職名
教授

学位 1

  1. 博士(情報科学) ( 2007年3月   北海道大学 ) 

研究分野 2

  1. その他 / その他  / バイオインフォマティクス

  2. その他 / その他  / システム生物学

経歴 4

  1. 東京大学 医科学研究所 助教

    2011年8月 - 2014年3月

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    国名:日本国

  2. 東京大学 医科学研究所 特任助教

    2010年4月 - 2011年7月

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    国名:日本国

  3. 東京大学 医科学研究所 特任研究員

    2007年4月 - 2010年3月

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    国名:日本国

  4. 日本学術振興会 特別研究員(DC2)

    2006年4月 - 2007年3月

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    国名:日本国

学歴 2

  1. 北海道大学   情報科学研究科

    - 2007年3月

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    国名: 日本国

  2. 北海道大学   工学研究科

    - 2004年3月

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    国名: 日本国

所属学協会 3

  1. 日本メディカルAI学会

  2. 日本生化学会

  3. 日本分子生物学会

 

論文 64

  1. A mixture-of-experts multimodal deep generative model for single-cell multiomics data analysis 招待有り 査読有り

    Minoura K, Abe K, Nam H, Nishikawa H, Shimamura T.

    Cell Reports Methods     2021年9月

  2. Hierarchical non-negative matrix factorization using clinical information for microbial communities.

    Abe K, Hirayama M, Ohno K, Shimamura T

    BMC genomics   22 巻 ( 1 ) 頁: 104   2021年2月

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  3. Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder.

    Nishiwaki H, Hamaguchi T, Ito M, Ishida T, Maeda T, Kashihara K, Tsuboi Y, Ueyama J, Shimamura T, Mori H, Kurokawa K, Katsuno M, Hirayama M, Ohno K

    mSystems   5 巻 ( 6 )   2020年12月

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  4. CYBERTRACK2.0: zero-inflated model-based cell clustering and population tracking method for longitudinal mass cytometry data.

    Minoura K, Abe K, Maeda Y, Nishikawa H, Shimamura T

    Bioinformatics (Oxford, England)     2020年10月

  5. Model-based clustering for flow and mass cytometry data with clinical information

    Abe Ko, Minoura Kodai, Maeda Yuka, Nishikawa Hiroyoshi, Shimamura Teppei

    BMC BIOINFORMATICS   21 巻 ( Suppl 13 ) 頁: 393   2020年9月

  6. Meta-Analysisof Gut Dysbiosis in Parkinson's Disease

    Nishiwaki Hiroshi, Ito Mikako, Ishida Tomohiro, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Shimamura Teppei, Mori Hiroshi, Kurokawa Ken, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

    MOVEMENT DISORDERS   35 巻 ( 9 ) 頁: 1626 - 1635   2020年9月

  7. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk

    Sekiguchi Mariko, Sobue Akira, Kushima Itaru, Wang Chenyao, Arioka Yuko, Kato Hidekazu, Kodama Akiko, Kubo Hisako, Ito Norimichi, Sawahata Masahito, Hada Kazuhiro, Ikeda Ryosuke, Shinno Mio, Mizukoshi Chikara, Tsujimura Keita, Yoshimi Akira, Ishizuka Kanako, Takasaki Yuto, Kimura Hiroki, Xing Jingrui, Yu Yanjie, Yamamoto Maeri, Okada Takashi, Shishido Emiko, Inada Toshiya, Nakatochi Masahiro, Takano Tetsuya, Kuroda Keisuke, Amano Mutsuki, Aleksic Branko, Yamomoto Takashi, Sakuma Tetsushi, Aida Tomomi, Tanaka Kohichi, Hashimoto Ryota, Arai Makoto, Ikeda Masashi, Iwata Nakao, Shimamura Teppei, Nagai Taku, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi, Mori Daisuke, Ozaki Norio

    TRANSLATIONAL PSYCHIATRY   10 巻 ( 1 ) 頁: 247   2020年7月

  8. Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets

    Sekiguchi Masahiro, Seki Masafumi, Kawai Tomoko, Yoshida Kenichi, Yoshida Misa, Isobe Tomoya, Hoshino Noriko, Shirai Ryota, Tanaka Mio, Souzaki Ryota, Watanabe Kentaro, Arakawa Yuki, Nannya Yasuhito, Suzuki Hiromichi, Fujii Yoichi, Kataoka Keisuke, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Shimamura Teppei, Sato Yusuke, Sato-Otsubo Aiko, Kimura Shunsuke, Kubota Yasuo, Hiwatari Mitsuteru, Koh Katsuyoshi, Hayashi Yasuhide, Kanamori Yutaka, Kasahara Mureo, Kohashi Kenichi, Kato Motohiro, Yoshioka Takako, Matsumoto Kimikazu, Oka Akira, Taguchi Tomoaki, Sanada Masashi, Tanaka Yukichi, Miyano Satoru, Hata Kenichiro, Ogawa Seishi, Takita Junko

    NPJ PRECISION ONCOLOGY   4 巻 ( 1 ) 頁: 20   2020年7月

  9. EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells

    Yoshino Seiko, Matsui Yusuke, Fukui Yuya, Seki Masahide, Yamaguchi Kiyoshi, Kanamori Akane, Saitoh Yurika, Shimamura Teppei, Suzuki Yutaka, Furukawa Yoichi, Kaneko Shuichi, Seiki Motoharu, Murakami Yoshinori, Inoue Jun-ichiro, Sakamoto Takeharu

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 9275   2020年6月

  10. Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

    Higashijima Yoshiki, Matsui Yusuke, Shimamura Teppei, Nakaki Ryo, Nagai Nao, Tsutsumi Shuichi, Abe Yohei, Link Verena M., Osaka Mizuko, Yoshida Masayuki, Watanabe Ryo, Tanaka Toshihiro, Taguchi Akashi, Miura Mai, Ruan Xiaoan, Li Guoliang, Inoue Tsuyoshi, Nangaku Masaomi, Kimura Hiroshi, Furukawa Tetsushi, Aburatani Hiroyuki, Wada Youichiro, Ruan Yijun, Glass Christopher K., Kanki Yasuharu

    EMBO JOURNAL   39 巻 ( 7 ) 頁: e103949   2020年4月

  11. Model-based cell clustering and population tracking for time-series flow cytometry data

    Minoura Kodai, Abe Ko, Maeda Yuka, Nishikawa Hiroyoshi, Shimamura Teppei

    BMC BIOINFORMATICS   20 巻 ( 1 ) 頁: 633   2019年12月

  12. Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis

    Mizutani Yasuyuki, Kobayashi Hiroki, Iida Tadashi, Asai Naoya, Masamune Atsushi, Hara Akitoshi, Esaki Nobutoshi, Ushida Kaori, Mii Shinji, Shiraki Yukihiro, Ando Kenju, Weng Liang, Ishihara Seiichiro, Ponik Suzanne M., Conklin Matthew W., Haga Hisashi, Nagasaka Arata, Miyata Takaki, Matsuyama Makoto, Kobayashi Tomoe, Fujii Tsutomu, Yamada Suguru, Yamaguchi Junpei, Wang Tongtong, Woods Susan L., Worthley Daniel, Shimamura Teppei, Fujishiro Mitsuhiro, Hirooka Yoshiki, Enomoto Atsushi, Takahashi Masahide

    CANCER RESEARCH   79 巻 ( 20 ) 頁: 5367 - 5381   2019年10月

  13. Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas

    Ohka Fumiharu, Shinjo Keiko, Deguchi Shoichi, Matsui Yusuke, Okuno Yusuke, Katsushima Keisuke, Suzuki Miho, Kato Akira, Ogiso Noboru, Yamamichi Akane, Aoki Kosuke, Suzuki Hiromichi, Sato Shinya, Rayan Nirmala Arul, Prabhakar Shyam, Goke Jonathan, Shimamura Teppei, Maruyama Reo, Takahashi Satoru, Suzumura Akio, Kimura Hiroshi, Wakabayashi Toshihiko, Zong Hui, Natsume Atsushi, Kondo Yutaka

    CANCER RESEARCH   79 巻 ( 19 ) 頁: 4814 - 4827   2019年10月

  14. Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

    Osawa Tsuyoshi, Shimamura Teppei, Saito Kyoko, Hasegawa Yoko, Ishii Naoko, Nishida Miyuki, Ando Ritsuko, Kondo Ayano, Anwar Muyassar, Tsuchida Rika, Hino Shinjiro, Sakamoto Akihisa, Igarashi Kaori, Saitoh Kaori, Kato Keiko, Endo Keiko, Yamano Shotaro, Kanki Yasuharu, Matsumura Yoshihiro, Minami Takashi, Tanaka Toshiya, Anai Motonobu, Wada Youichiro, Wanibuchi Hideki, Hayashi Mitsuhiro, Hamada Akinobu, Yoshida Masayuki, Yachida Shinichi, Nakao Mitsuyoshi, Sakai Juro, Aburatani Hiroyuki, Shibuya Masabumi, Hanada Kentaro, Miyano Satoru, Soga Tomoyoshi, Kodama Tatsuhiko

    CELL REPORTS   29 巻 ( 1 ) 頁: 89 - +   2019年10月

  15. Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction

    Kajino Taisuke, Shimamura Teppei, Gong Shuyi, Yanagisawa Kiyoshi, Ida Lisa, Nakatochi Masahiro, Griesing Sebastian, Shimada Yukako, Kano Keiko, Suzuki Motoshi, Miyano Satoru, Takahashi Takashi

    EMBO JOURNAL   38 巻 ( 17 )   2019年9月

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  16. Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction.

    Kajino T, Shimamura T, Gong S, Yanagisawa K, Ida L, Nakatochi M, Griesing S, Shimada Y, Kano K, Suzuki M, Miyano S, Takahashi T

    The EMBO journal   38 巻 ( 17 ) 頁: e98441   2019年9月

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  17. Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

    Matsuno Yusuke, Atsumi Yuko, Shimizu Atsuhiro, Katayama Kotoe, Fujimori Haruka, Hyodo Mai, Minakawa Yusuke, Nakatsu Yoshimichi, Kaneko Syuzo, Hamamoto Ryuji, Shimamura Teppei, Miyano Satoru, Tsuzuki Teruhisa, Hanaoka Fumio, Yoshioka Ken-ichi

    NATURE COMMUNICATIONS   10 巻 ( 1 ) 頁: 3925   2019年9月

  18. A network of networks approach for modeling interconnected brain tissue-specific networks

    Kawakubo Hideko, Matsui Yusuke, Kushima Itaru, Ozaki Norio, Shimamura Teppei

    BIOINFORMATICS   35 巻 ( 17 ) 頁: 3092 - 3101   2019年9月

  19. Distinct methylation levels of mature microRNAs in gastrointestinal cancers

    Konno Masamitsu, Koseki Jun, Asai Ayumu, Yamagata Akira, Shimamura Teppei, Motooka Daisuke, Okuzaki Daisuke, Kawamoto Koichi, Mizushima Tsunekazu, Eguchi Hidetoshi, Takiguchi Shuji, Satoh Taroh, Mimori Koshi, Ochiya Takahiro, Doki Yuichiro, Ofusa Ken, Mori Masaki, Ishii Hideshi

    NATURE COMMUNICATIONS   10 巻 ( 1 ) 頁: 3888   2019年8月

  20. Myxofibrosarcoma is characterized by frequent abnormalities in TP53 and increased genetic instability

    Takeuchi Yasuhide, Kunitz Annegret, Suzuki Hiromichi, Yoshida Kenichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Shimamura Teppei, Kakiuchi Nobuyuki, Shiozawa Yusuke, Yokoyama Akira, Yoshizato Tetsuichi, Aoki Kosuke, Fujii Yoichi, Nannya Yasuhito, Makishima Hideki, Miyano Satoru, Haga Hironori, Damm Frederik, Ogawa Seishi

    CANCER RESEARCH   79 巻 ( 13 )   2019年7月

  21. ENIGMA: an enterotype-like unigram mixture model for microbial association analysis

    Abe Ko, Hirayama Masaaki, Ohno Kinji, Shimamura Teppei

    BMC GENOMICS   20 巻 ( Suppl 2 ) 頁: 191   2019年4月

  22. Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

    Kidoya Hiroyasu, Muramatsu Fumitaka, Shimamura Teppei, Jia Weizhen, Satoh Takashi, Hayashi Yumiko, Naito Hisamichi, Kunisaki Yuya, Arai Fumio, Seki Masahide, Suzuki Yutaka, Osawa Tsuyoshi, Akira Shizuo, Takakura Nobuyuki

    NATURE COMMUNICATIONS   10 巻 ( 1 ) 頁: 1072   2019年3月

  23. A latent allocation model for the analysis of microbial composition and disease

    Abe Ko, Hirayama Masaaki, Ohno Kinji, Shimamura Teppei

    BMC BIOINFORMATICS   19 巻 ( Suppl 19 ) 頁: 519   2018年12月

  24. Metabolic Alterations Promotes Tumor Progression under Amino Acids deprivation

    Osawa Tsuyoshi, Shimamura Teppei, Kondo Ayano, Tsuchida Rika, Miyano Satoru, Aburatani Hiroyuki, Shibuya Masabumi, Kodama Tatsuhiko

    CANCER SCIENCE   109 巻   頁: 194 - 194   2018年12月

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  25. Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights

    Kushima Itaru, Aleksic Branko, Nakatochi Masahiro, Shimamura Teppei, Okada Takashi, Uno Yota, Morikawa Mako, Ishizuka Kanako, Shiino Tomoko, Kimura Hiroki, Arioka Yuko, Yoshimi Akira, Takasaki Yuto, Yu Yanjie, Nakamura Yukako, Yamamoto Maeri, Iidaka Tetsuya, Iritani Shuji, Inada Toshiya, Ogawa Nanayo, Shishido Emiko, Torii Youta, Kawano Naoko, Omura Yutaka, Yoshikawa Toru, Uchiyama Tokio, Yamamoto Toshimichi, Ikeda Masashi, Hashimoto Ryota, Yamamori Hidenaga, Yasuda Yuka, Someya Toshiyuki, Watanabe Yuichiro, Egawa Jun, Nunokawa Ayako, Itokawa Masanari, Arai Makoto, Miyashita Mitsuhiro, Kobori Akiko, Suzuki Michio, Takahashi Tsutomu, Usami Masahide, Kodaira Masaki, Watanabe Kyota, Sasaki Tsukasa, Kuwabara Hitoshi, Tochigi Mamoru, Nishimura Fumichika, Yamasue Hidenori, Eriguchi Yosuke, Benner Seico, Kojima Masaki, Yassin Walid, Munesue Toshio, Yokoyama Shigeru, Kimura Ryo, Funabiki Yasuko, Kosaka Hirotaka, Ishitobi Makoto, Ohmori Tetsuro, Numata Shusuke, Yoshikawa Takeo, Toyota Tomoko, Yamakawa Kazuhiro, Suzuki Toshimitsu, Inoue Yushi, Nakaoka Kentaro, Goto Yu-ichi, Inagaki Masumi, Hashimoto Naoki, Kusumi Ichiro, Son Shuraku, Murai Toshiya, Ikegame Tempei, Okada Naohiro, Kasai Kiyoto, Kunimoto Shohko, Mori Daisuke, Iwata Nakao, Ozaki Norio

    CELL REPORTS   24 巻 ( 11 ) 頁: 2838 - 2856   2018年9月

  26. A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer

    Saito Tomoko, Niida Atsushi, Uchi Ryutaro, Hirata Hidenari, Komatsu Hisateru, Sakimura Shotaro, Hayashi Shuto, Nambara Sho, Kuroda Yosuke, Ito Shuhei, Eguchi Hidetoshi, Masuda Takaaki, Sugimachi Keishi, Tobo Taro, Nishida Haruto, Daa Tsutomu, Chiba Kenichi, Shiraishi Yuichi, Yoshizato Tetsuichi, Kodama Masaaki, Okimoto Tadayoshi, Mizukami Kazuhiro, Ogawa Ryo, Okamoto Kazuhisa, Shuto Mitsutaka, Fukuda Kensuke, Matsui Yusuke, Shimamura Teppei, Hasegawa Takanori, Doki Yuichiro, Nagayama Satoshi, Yamada Kazutaka, Kato Mamoru, Shibata Tatsuhiro, Mori Masaki, Aburatani Hiroyuki, Murakami Kazunari, Suzuki Yutaka, Ogawa Seishi, Miyano Satoru, Mimori Koshi

    NATURE COMMUNICATIONS   9 巻 ( 1 ) 頁: 2884   2018年7月

  27. ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D

    Komura Kazumasa, Yoshikawa Yuki, Shimamura Teppei, Chakraborty Goutam, Gerke Travis A., Hinohara Kunihiko, Chadalavada Kalyani, Jeong Seong Ho, Armenia Joshua, Du Shin-Yi, Mazzu Ying Z., Taniguchi Kohei, Ibuki Naokazu, Meyer Clifford A., Nanjangud Gouri J., Inamoto Teruo, Lee Gwo-Shu Mary, Mucci Lorelei A., Azuma Haruhito, Sweeney Christopher J., Kantoff Philip W.

    JOURNAL OF CLINICAL INVESTIGATION   128 巻 ( 7 ) 頁: 2979 - 2995   2018年7月

  28. Comprehensive analysis of genetic alterations and intratumor heterogeneity in myxofibrosarcoma

    Takeuchi Yasuhide, Kunitz Annegret, Suzuki Hiromichi, Yoshida Kenichi, Kakiuchi Nobuyuki, Shiozawa Yusuke, Yokoyama Akira, Fujii Yoichi, Yoshizato Tetsuichi, Aoki Kosuke, Kataoka Keisuke, Nannya Yasuhito, Shiraishi Yuichi, Shimamura Teppei, Chiba Kenichi, Tanaka Hiroko, Makishima Hideki, Miyano Satoru, Haga Hironori, Damm Frederik, Ogawa Seishi

    CANCER RESEARCH   78 巻 ( 13 )   2018年7月

  29. Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction

    Kajino Taisuke, Shimamura Teppei, Gong Shuyi, Yanagisawa Kiyoshi, Nakatochi Masahiro, Griesing Sebastian, Shimada Yukako, Kano Keiko, Suzuki Motoshi, Miyano Satoru, Takahashi Takashi

    CANCER RESEARCH   78 巻 ( 13 )   2018年7月

  30. ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors

    Terai Hideki, Kitajima Shunsuke, Potter Danielle S., Matsui Yusuke, Quiceno Laura Gutierrez, Chen Ting, Kim Tae-jung, Rusan Maria, Thai Tran C., Piccioni Federica, Donovan Katherine A., Kwiatkowski Nicholas, Hinohara Kunihiko, Wei Guo, Gray Nathanael S., Fischer Eric S., Wong Kwok-Kin, Shimamura Teppei, Letai Anthony, Hammerman Peter S., Barbie David A.

    CANCER RESEARCH   78 巻 ( 4 ) 頁: 1044 - 1057   2018年2月

  31. Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma

    Isobe Tomoya, Seki Masafumi, Yoshida Kenichi, Sekiguchi Masahiro, Shiozawa Yusuke, Shiraishi Yuichi, Kimura Shunsuke, Yoshida Misa, Inoue Yoshikage, Yokoyama Akira, Kakiuchi Nobuyuki, Suzuki Hiromichi, Kataoka Keisuke, Sato Yusuke, Kawai Tomoko, Chiba Kenichi, Tanaka Hiroko, Shimamura Teppei, Kato Motohiro, Iguchi Akihiro, Hama Asahito, Taguchi Tomoaki, Akiyama Masaharu, Fujimura Junya, Inoue Akiko, Ito Tsuyoshi, Deguchi Takao, Kiyotani Chikako, Iehara Tomoko, Hosoi Hajime, Oka Akira, Sanada Masashi, Tanaka Yukichi, Hata Kenichiro, Miyano Satoru, Ogawa Seishi, Takita Junko

    CANCER RESEARCH   78 巻 ( 4 ) 頁: 865 - 876   2018年2月

  32. Adaptive NetworkProfiler for Identifying Cancer Characteristic-Specific Gene Regulatory Networks

    Park Heewon, Shimamura Teppei, Imoto Seiya, Miyano Satoru

    JOURNAL OF COMPUTATIONAL BIOLOGY   25 巻 ( 2 ) 頁: 130 - 145   2018年2月

  33. Comprehensive genetic analysis of donor cell derived leukemia with KMT2A rearrangement

    Taniguchi Rieko, Muramatsu Hideki, Okuno Yusuke, Suzuki Kyogo, Obu Satoshi, Nakatochi Masahiro, Shimamura Teppei, Takahashi Yoshiyuki, Horikoshi Yasuo, Watanabe Kenichiro, Kojima Seiji

    PEDIATRIC BLOOD & CANCER   65 巻 ( 2 )   2018年2月

  34. Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82

    Takeda Masafumi, Kanki Yasuharu, Masumoto Hidetoshi, Funakoshi Shunsuke, Hatani Takeshi, Fukushima Hiroyuki, Izumi-Taguchi Akashi, Matsui Yusuke, Shimamura Teppei, Yoshida Yoshinori, Yamashita Jun K.

    CELL REPORTS   22 巻 ( 2 ) 頁: 546 - 556   2018年1月

  35. Long non-coding RNA X promotes tumor growth by regulating angiogenesis in response to nutrient starvation

    Kondo Ayano, Nonaka Aya, Shimamura Teppei, Yamamoto Shogo, Yoshida Tetsuo, Kodama Tatsuhiko, Aburatani Hiroyuki, Osawa Tsuyoshi

    CANCER SCIENCE   109 巻   頁: 120 - 120   2018年1月

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  36. Comprehensive Analysis of Genetic Alterations and Intratumor Heterogeneity in Myxofibrosarcoma

    Takeuchi Yasuhide, Suzuki Hiromichi, Yoshida Kenichi, Shiraish Yuichi, Shimamura Teppei, Yoshizato Tetsuichi, Shiozawa Yusuke, Chiba Kenichi, Makishima Hideki, Miyano Satoru, Haga Hironori, Damm Frederik, Ogawa Seishi

    CANCER SCIENCE   109 巻   頁: 716 - 716   2018年1月

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  37. Systems biology-based identification of MYMLR lncRNA modulating MYC oncogene

    Kajino Taisuke, Shimamura Teppei, Gong Shuyi, Yanagisawa Kiyoshi, Nakatochi Masahiro, Griesing Sebastian, Shimada Yukako, Kano Keiko, Miyano Satoru, Takahashi Takashi

    CANCER SCIENCE   109 巻   頁: 399 - 399   2018年1月

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  38. Prognostic relevance of genetic alterations in diffuse lower-grade gliomas

    Aoki Kosuke, Nakamura Hideo, Suzuki Hiromichi, Matsuo Keitaro, Kataoka Keisuke, Shimamura Teppei, Motomura Kazuya, Ohka Fumiharu, Shiina Satoshi, Yamamoto Takashi, Nagata Yasunobu, Yoshizato Tetsuichi, Mizoguchi Masahiro, Abe Tatsuya, Momii Yasutomo, Muragaki Yoshihiro, Watanabe Reiko, Ito Ichiro, Sanada Masashi, Yajima Hironori, Morita Naoya, Takeuchi Ichiro, Miyano Satoru, Wakabayashi Toshihiko, Ogawa Seishi, Natsume Atsushi

    NEURO-ONCOLOGY   20 巻 ( 1 ) 頁: 66 - 77   2018年1月

  39. Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14

    Takahashi Yusuke, Sugimachi Keishi, Yamamoto Ken, Niida Atsushi, Shimamura Teppei, Sato Tetsuya, Watanabe Masahiko, Tanaka Junichi, Kudo Shinei, Sugihara Kenichi, Hase Kazuo, Kusunoki Masato, Yamada Kazutaka, Shimada Yasuhiro, Moriya Yoshihiro, Suzuki Yutaka, Miyano Satoru, Mori Masaki, Mimori Koshi

    CANCER SCIENCE   108 巻 ( 11 ) 頁: 2239 - 2247   2017年11月

  40. PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma

    Tsubota Shoma, Kishida Satoshi, Shimamura Teppei, Ohira Miki, Yamashita Satoshi, Cao Dongliang, Kiyonari Shinichi, Ushijima Toshikazu, Kadomatsu Kenji

    CANCER RESEARCH   77 巻 ( 19 ) 頁: 5259 - 5271   2017年10月

  41. Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation

    Kondo Ayano, Nonaka Aya, Shimamura Teppei, Yamamoto Shogo, Yoshida Tetsuo, Kodama Tatsuhiko, Aburatani Hiroyuki, Osawae Tsuyoshi

    MOLECULAR AND CELLULAR BIOLOGY   37 巻 ( 18 )   2017年9月

  42. Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia

    Seki Masafumi, Kimura Shunsuke, Isobe Tomoya, Yoshida Kenichi, Ueno Hiroo, Nakajima-Takagi Yaeko, Wang Changshan, Lin Lin, Kon Ayana, Suzuki Hiromichi, Shiozawa Yusuke, Kataoka Keisuke, Fujii Yoichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Shimamura Teppei, Masuda Kyoko, Kawamoto Hiroshi, Ohki Kentaro, Kato Motohiro, Arakawa Yuki, Koh Katsuyoshi, Hanada Ryoji, Moritake Hiroshi, Akiyama Masaharu, Kobayashi Ryoji, Deguchi Takao, Hashii Yoshiko, Imamura Toshihiko, Sato Atsushi, Kiyokawa Nobutaka, Oka Akira, Hayashi Yasuhide, Takagi Masatoshi, Manabe Atsushi, Ohara Akira, Horibe Keizo, Sanada Masashi, Iwama Atsushi, Mano Hiroyuki, Miyano Satoru, Ogawa Seishi, Takita Junko

    NATURE GENETICS   49 巻 ( 8 ) 頁: 1274 - +   2017年8月

  43. IDENTIFICATIONS OF NOVEL RECURRENT PU.1 FUSIONS WITH HIGHLY AGGRESSIVE PHENOTYPE IN PEDIATRIC T CELL ACUTE LYMPHOBLASTIC LEUKEMIA

    Seki M., Kimura S., Isobe T., Yoshida K., Ueno H., Suzuki H., Shiozawa Y., Kataoka K., Fujii Y., Shiraishi Y., Chiba K., Tanaka H., Shimamura T., Lin L., Takagi M., Wang C., Iwama A., Ohki K., Kato M., Arakawa Y., Koh K., Hanada R., Moritake H., Akiyama M., Kobayashi R., Deguchi T., Hashii Y., Imamura T., Sato A., Kiyokawa N., Oka A., Hayashi Y., Manabe A., Ohara A., Horibe K., Sanada M., Mano H., Miyano S., Ogawa S., Takita J.

    HAEMATOLOGICA   102 巻   頁: 327 - 328   2017年6月

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  44. Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation

    Kanki Yasuharu, Nakaki Ryo, Shimamura Teppei, Matsunaga Taichi, Yamamizu Kohei, Katayama Shiori, Suehiro Jun-ichi, Osawa Tsuyoshi, Aburatani Hiroyuki, Kodama Tatsuhiko, Wada Youichiro, Yamashita Jun K., Minami Takashi

    NUCLEIC ACIDS RESEARCH   45 巻 ( 8 ) 頁: 4344 - 4358   2017年5月

  45. phyC: Clustering cancer evolutionary trees

    Matsui Yusuke, Niida Atsushi, Uchi Ryutaro, Mimori Koshi, Miyano Satoru, Shimamura Teppei

    PLOS COMPUTATIONAL BIOLOGY   13 巻 ( 5 ) 頁: e1005509   2017年5月

  46. Correction: Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.

    Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, Kurashige J, Shinden Y, Iguchi T, Eguchi H, Chiba K, Shiraishi Y, Nagae G, Yoshida K, Nagata Y, Haeno H, Yamamoto H, Ishii H, Doki Y, Iinuma H, Sasaki S, Nagayama S, Yamada K, Yachida S, Kato M, Shibata T, Oki E, Saeki H, Shirabe K, Oda Y, Maehara Y, Komune S, Mori M, Suzuki Y, Yamamoto K, Aburatani H, Ogawa S, Miyano S, Mimori K

    PLoS genetics   13 巻 ( 5 ) 頁: e1006798   2017年5月

  47. High-resolution copy number variation analysis of schizophrenia in Japan

    Kushima I., Aleksic B., Nakatochi M., Shimamura T., Shiino T., Yoshimi A., Kimura H., Takasaki Y., Wang C., Xing J., Ishizuka K., Oya-Ito T., Nakamura Y., Arioka Y., Maeda T., Yamamoto M., Yoshida M., Noma H., Hamada S., Morikawa M., Uno Y., Okada T., Iidaka T., Iritani S., Yamamoto T., Miyashita M., Kobori A., Arai M., Itokawa M., Cheng M-C, Chuang Y-A, Chen C-H, Suzuki M., Takahashi T., Hashimoto R., Yamamori H., Yasuda Y., Watanabe Y., Nunokawa A., Someya T., Ikeda M., Toyota T., Yoshikawa T., Numata S., Ohmori T., Kunimoto S., Mori D., Iwata N., Ozaki N.

    MOLECULAR PSYCHIATRY   22 巻 ( 3 ) 頁: 430 - 440   2017年3月

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  48. Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression

    Kondo Ayano, Yamamoto Shogo, Nakaki Ryo, Shimamura Teppei, Hamakubo Takao, Sakai Juro, Kodama Tatsuhiko, Yoshida Tetsuo, Aburatani Hiroyuki, Osawa Tsuyoshi

    CELL REPORTS   18 巻 ( 9 ) 頁: 2228 - 2242   2017年2月

  49. Aberrant Methylation of FOXE1 Contributes to a Poor Prognosis for Patients with Colorectal Cancer 査読有り

    Sugimachi K, Matsumura T, Shimamura T, Hirata H, Uchi R, Ueda M, Sakimura S, Iguchi T, Eguchi H, Masuda T, Morita K, Takenaka K, Maehara Y, Mori M, Mimori K

    Ann Surg Oncol   23 巻 ( 12 ) 頁: 3948-3955   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  50. D3M: detection of differential distributions of methylation levels 査読有り

    Matsui Y, Mizuta M, Ito S, Miyano S, Shimamura T

    Bioinformatics   32 巻 ( 15 ) 頁: 2248-2255   2016年8月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/bioinformatics/btw138

  51. NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells 査読有り

    Nakaoka HJ, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, Sato H, Murakami Y, Seiki M, Sakamoto T

    Sci Rep   6 巻   頁: 22784   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/srep22784

  52. Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population

    Sawada G, Niida A, Uchi R, Hirata H, Shimamura T, Suzuki Y, Shiraishi Y, Chiba K, Imoto S, Takahashi Y, Iwaya T, Sudo T, Hayashi T, Takai H, Kawasaki Y, Matsukawa T, Eguchi H, Sugimachi K, Tanaka F, Suzuki H, Yamamoto K, Ishii H, Shimizu M, Yamazaki H, Yamazaki M, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Mafune K, Tanaka Y, Kelsell DP, Scott CA, Tsuji S, Yachida S, Shibata T, Sugano S, Doki Y, Akiyama T, Aburatani H, Ogawa S, Miyano S, Mori M, Mimori K

    Gastroenterology   150 巻 ( 5 ) 頁: 1171-1182   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1053/j.gastro.2016.01.035

  53. Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution 査読有り

    Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, Kurashige J, Shinden Y, Iguchi T, Eguchi H, Chiba K, Shiraishi Y, Nagae G, Yoshida K, Nagata Y, Haeno H, Yamamoto H, Ishii H, Doki Y, Iinuma H, Sasaki S, Nagayama S, Yamada K, Yachida S, Kato M, Shibata T, Oki E, Saeki H, Shirabe K, Oda Y, Maehara Y, Komune S, Mori M, Suzuki Y, Yamamoto K, Aburatani H, Ogawa S, Miyano S, Mimori K

    PLoS Genet   12 巻 ( 2 ) 頁: e1005778   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pgen.1005778

  54. An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma 査読有り

    Sawada G, Niida A, Hirata H, Komatsu H, Uchi R, Shimamura T, Takahashi Y, Kurashige J, Matsumura T, Ueo H, Takano Y, Ueda M, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Yamasaki M, Tanaka F, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Tanaka Y, Calin G, Miyano S, Doki Y, Mori M, Mimori K

    PLoS One   10 巻 ( 10 ) 頁: e0139808   2015年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0139808

  55. Integrated molecular analysis of adult T cell leukemia/lymphoma

    Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga JI, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S

    Nature Genetics     2015年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/ng.3415

  56. Elevated β-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs

    Nakata A, Yoshida R, Yamaguchi R, Yamauchi M, Tamada Y, Fujita A, Shimamura T, Imoto S, Higuchi T, Nomura M, Kimura T, Nokihara H, Higashiyama M, Kondoh K, Nishihara H, Tojo A, Yano S, Miyano S, Gotoh N

    Scientific Reports   5 巻   頁: 13076   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/srep13076

  57. Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma

    Seki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, Kato M, Chiba K, Tanaka H, Hoshino N, Nagae G, Shiozawa Y, Okuno Y, Hosoi H, Tanaka Y, Okita H, Miyachi M, Souzaki R, Taguchi T, Koh K, Hanada R, Kato K, Nomura Y, Akiyama M, Oka A, Igarashi T, Miyano S, Aburatani H, Hayashi Y, Ogawa S, Takita J

    Nature Communications   6 巻   頁: 7557   2015年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/ncomms8557

  58. Genomic data assimilation using a higher moment filtering technique for restoration of gene regulatory networks

    Hasegawa T, Mori T, Yamaguchi R, Shimamura T, Miyano S, Imoto S, Akutsu T

      9 巻   頁: 14   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12918-015-0154-2

  59. Mutational landscape and clonal architecture in grade II and III gliomas

    Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y, Shimamura T, Niida A, Motomura K, Ohka F, Yamamoto T, Tanahashi K, Ranjit M, Wakabayashi T, Yoshizato T, Kataoka K, Yoshida K, Nagata Y, Sato-Otsubo A, Tanaka H, Sanada M, Kondo Y, Nakamura H, Mizoguchi M, Abe T, Muragaki Y, Watanabe R, Ito I, Miyano S, Natsume A, Ogawa S

      47 巻 ( 5 ) 頁: 458-68   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/ng.3273

  60. Loss of CDCP1 expression promotes invasiveness and poor prognosis in esophageal squamous cell carcinoma

    Sawada G, Takahashi Y, Niida A, Shimamura T, Kurashige J, Matsumura T, Ueo H, Uchi R, Takano Y, Ueda M, Hirata H, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Miyano S, Doki Y, Mori M, Mimori K

    Annals of Surgical Oncology     頁: S640-7   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-014-3740-4

  61. Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer

    Sugimachi K, Niida A, Yamamoto K, Shimamura T, Imoto S, Iinuma H, Shinden Y, Eguchi H, Sudo T, Watanabe M, Tanaka J, Kudo S, Hase K, Kusunoki M, Yamada K, Shimada Y, Sugihara K, Maehara Y, Miyano S, Mori M, Mimori K

        頁: S515-21   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-013-3468-6

  62. Robust prediction of anti-cancer drug sensitivity and sensitivity-specific biomarker

    Park H, Shimamura T, Miyano S, Imoto S

    PLoS One   9 巻 ( 10 ) 頁: e108990   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0108990

  63. Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma

    Seki M, Yoshida K, Shiraishi Y, Shimamura T, Sato Y, Nishimura R, Okuno Y, Chiba K, Tanaka H, Kato K, Kato M, Hanada R, Nomura Y, Park MJ, Ishida T, Oka A, Igarashi T, Miyano S, Hayashi Y, Ogawa S, Takita J

    Cancer Research   74 巻 ( 10 ) 頁: 2742-9   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1158/0008-5472.CAN-13-2470

  64. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. 査読有り

    Barclay SS, Tamura T, Ito H, Fujita K, Tagawa K, Shimamura T, Katsuta A, Shiwaku H, Sone M, Imoto S, Miyano S, Okazawa H

    Human Molecular Genetics   23 巻 ( 5 ) 頁: 1345-64   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/hmg/ddt524.

▼全件表示

科研費 4

  1. 細胞内代謝シフトを解析、統合、理解するためのベイズモデリング

    2015年4月 - 2019年3月

    科学研究費補助金  若手研究(A)

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    担当区分:研究代表者 

  2. 機能性ncRNA探索のための転写調節ネットワークアトラス

    2015年4月 - 2018年3月

    科学研究費補助金 

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    担当区分:研究代表者 

  3. 高次エピゲノムが生み出す生命情報を読み解く統計解析法の開発

    2013年4月 - 2016年3月

    科学研究費補助金  若手研究(B)

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    担当区分:研究代表者 

  4. 計算とシミュレーションによるがんシステム学の創成

    2010年6月 - 2015年3月

    科学研究費補助金  新学術領域研究

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    担当区分:研究分担者