Updated on 2022/05/02

写真a

 
NONOBE Norie
 
Organization
Nagoya University Hospital Maternity and Perinatal Care Center Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. 医学博士 ( 2010.3 ) 

Research Areas 1

  1. Others / Others  / 小児網膜疾患

Professional Memberships 1

  1. 小児眼科学会   会員

    2014.5

 

Papers 23

  1. Establishment of in-hospital clinical network for patients with neurofibromatosis type 1 in Nagoya University Hospital Reviewed

    Nishida Yoshihiro, Ikuta Kunihiro, Natsume Atsushi, Ishihara Naoko, Morikawa Maki, Kidokoro Hiroyuki, Muramatsu Yukako, Nonobe Norie, Ishizuka Kanako, Takeichi Takuya, Kanbe Miki, Mizuno Seiji, Imagama Shiro, Ozaki Norio

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 11933   2021.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-91345-6

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  2. Effect of internal limiting membrane peeling on visual field sensitivity in eyes with epiretinal membrane accompanied by glaucoma with hemifield defect and myopia Reviewed

    Kaneko Hiroki, Hirata Norifumi, Shimizu Hideyuki, Kataoka Keiko, Nonobe Norie, Mokuno Kumiko, Terasaki Hiroko

    JAPANESE JOURNAL OF OPHTHALMOLOGY     2021.2

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10384-021-00817-9

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  3. n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Muller BDNF in Diabetic Retinopathy Reviewed

    Suzumura Ayana, Kaneko Hiroki, Funahashi Yasuhito, Takayama Kei, Nagaya Masatoshi, Ito Seina, Okuno Toshiaki, Hirakata Toshiaki, Nonobe Norie, Kataoka Keiko, Shimizu Hideyuki, Namba Rina, Yamada Kazuhisa, Ye Fuxiang, Ozawa Yoko, Yokomizo Takehiko, Terasaki Hiroko

    DIABETES   Vol. 69 ( 4 ) page: 724 - 735   2020.4

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/db19-0550

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  4. Japan-Retinal Detachment Registry Report I: preoperative findings in eyes with primary retinal detachment Reviewed

    Sakamoto Taiji, Kawano Sumihiro, Kawasaki Ryo, Hirakata Akito, Yamashita Hidetoshi, Yamamoto Shuichi, Ishibashi Tatsuro, Yamamoto Shuichi, Baba Takayuki, Sato Eiju, Kitahashi Masayasu, Tatsumi Tomoaki, Miura Gen, Niizawa Tomohiro, Sakamoto Taiji, Yamakiri Keita, Yamashita Toshifumi, Otsuka Hiroki, Sameshima Seiji, Yoshinaga Narimasa, Sonoda Shozo, Hirakata Akito, Koto Takashi, Inoue Makoto, Hirota Kazunari, Itoh Yuji, Orihara Tadashi, Emoto Yoshinobu, Sano Masahiko, Takahashi Hiroyuki, Tokizawa Ryo, Yamashita Hidetoshi, Nishitsuka Koichi, Kaneko Yutaka, Nishi Katsuhiro, Yoshida Akitoshi, Ono Shinji, Hirokawa Hiroyuki, Sogawa Kenji, Omae Tsuneaki, Ishibazawa Akihiro, Kishi Shoji, Akiyama Hideo, Matsumoto Hidetaka, Mukai Ryo, Morimoto Masahiro, Nakazawa Mitsuru, Suzuki Yukihiko, Kudo Takashi, Adachi Kobu, Ishida Susumu, Noda Kousuke, Kase Satoru, Mori Syouhei, Ando Ryo, Saito Michiyuki, Suzuki Tomohiro, Takahashi Kanji, Nagai Yoshimi, Nakauchi Tadashi, Yamada Haruiko, Kusaka Shuji, Tsujioka Daishi, Tsujikawa Akitaka, Suzuma Kiyoshi, Ishibashi Tatsuro, Sonoda Koh-Hei, Ikeda Yasuhiro, Kohno Riichiro, Ishikawa Keijiro, Kondo Mineo, Kozawa Maki, Kitaoka Takashi, Tsuiki Eiko, Ogura Yuichiro, Yoshida Munenori, Morita Hiroshi, Kato Aki, Hirano Yoshio, Sugitani Kazuhiko, Terasaki Hiroko, Iwase Takeshi, Ito Yasuki, Ueno Shinji, Kaneko Hiroki, Nonobe Norie, Kominami Taro, Azuma Noriyuki, Yokoi Tadashi, Shimada Hiroyuki, Nakashizuka Hiroyuki, Hattori Takayuki, Shinojima Ari, Kutagawa Yorihisa, Shiraga Fumio, Morizane Yuki, Kimura Shuhei, Ikeda Tsunehiko, Kida Teruyo, Sato Takaki, Fukumoto Masanori, Emi Kazuyuki, Nakashima Hiroshi, Ohji Masahito, Kakinoki Masashi, Sawada Osamu, Takeuchi Shinobu, Tanaka Sumiyoshi, Iida Tomohiro, Koizumi Hideki, Maruko Ichiro, Hasegawa Taiji, Kogure Akiko, Iijima Hiroyuki, Oshiro Tomohiro, Tateno Yasushi, Kikushima Wataru, Sugiyama Atsushi, Yoneyama Seigo, Kadonosono Kazuaki, Sato Shimpei, Yamane Shin

    JAPANESE JOURNAL OF OPHTHALMOLOGY   Vol. 64 ( 1 ) page: 1 - 12   2020.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10384-019-00702-6

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  5. In Vitro Epiretinal Membrane Model and Antibody Permeability: Relationship With Anti-VEGF Resistance in Diabetic Macular Edema Reviewed

    Namba Rina, Kaneko Hiroki, Suzumura Ayana, Shimizu Hideyuki, Kataoka Keiko, Takayama Kei, Yamada Kazuhisa, Funahashi Yasuhito, Ito Seina, Nonobe Norie, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 60 ( 8 ) page: 2942 - 2949   2019.7

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.19-26788

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  6. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL AVASCULAR ZONE IN CHILDREN WITH A HISTORY OF TREATMENT-REQUIRING RETINOPATHY OF PREMATURITY. Reviewed

    Nonobe N, Kaneko H, Ito Y, Takayama K, Kataoka K, Tsunekawa T, Matsuura T, Suzumura A, Shimizu H, Terasaki H

    Retina (Philadelphia, Pa.)   Vol. 39 ( 1 ) page: 111 - 117   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/IAE.0000000000001937

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  7. Is hiragana decoding impaired in children with periventricular leukomalacia?

    Kurahashi Naoko, Futamura Yukiko, Nonobe Norie, Ogaya Shunsuke, Maki Yuki, Yoshimura Ikuko, Suzuki Takeshi, Hosokawa Yosuke, Yamada Keitaro, Aso Kosaburo, Maruyama Koichi, Nakamura Miho

    BRAIN & DEVELOPMENT   Vol. 40 ( 10 ) page: 850-856   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.braindev.2018.05.018

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  8. Changes in refractive characteristics in Japanese children with Down syndrome

    Horio Junna, Kaneko Hiroki, Takayama Kei, Tuzuki Kinichi, Kakihara Hiroko, Iwami Miou, Kawase Yoshikatsu, Tsunekawa Taichi, Yamaguchi Naoko, Nonobe Norie, Terasaki Hiroko

    JAPANESE JOURNAL OF OPHTHALMOLOGY   Vol. 62 ( 2 ) page: 231-236   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10384-018-0565-x

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  9. Changes in refractive characteristics in Japanese children with Down syndrome.

    Horio J, Kaneko H, Takayama K, Tuzuki K, Kakihara H, Iwami M, Kawase Y, Tsunekawa T, Yamaguchi N, Nonobe N, Terasaki H

    Japanese journal of ophthalmology     2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10384-018-0565-x

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  10. Quantitative evaluation of diabetic retinopathy using optical coherence tomography angiography

    Ito Yasuki, Taira Shoko, Iwase Takeshi, Nonobe Norie, Yasuda Shunsuke, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 58 ( 8 ) page: .   2017.6

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  11. Cytokine profiling in the sub-silicone oil fluid after vitrectomy surgeries for refractory retinal diseases.

    Kaneko H, Takayama K, Asami T, Ito Y, Tsunekawa T, Iwase T, Funahashi Y, Ueno S, Nonobe N, Yasuda S, Suzumura A, Shimizu H, Kimoto R, Hwang SJ, Terasaki H

    Scientific reports   Vol. 7 ( 1 ) page: 2640   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-03124-x

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  12. Cytokine profiling in the sub-silicone oil fluid after vitrectomy surgeries for refractory retinal diseases

    Kaneko Hiroki, Takayama Kei, Asami Tetsu, Ito Yasuki, Tsunekawa Taichi, Iwase Takeshi, Funahashi Yasuhito, Ueno Shinji, Nonobe Norie, Yasuda Shunsuke, Suzumura Ayana, Shimizu Hideyuki, Kimoto Reona, Hwang Shiang-Jyi, Terasaki Hiroko

    SCIENTIFIC REPORTS   Vol. 7   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-03124-x

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  13. Better Visual Outcome by Intraocular Lens Ejection in Geriatric Patients with Ruptured Ocular Injuries

    Kaneko Hiroki, Asami Tetsu, Sugita Tadasu, Tsunekawa Taichi, Matsuura Toshiyuki, Takayama Kei, Yamamoto Kentaro, Kachi Shu, Ito Yasuki, Ueno Shinji, Nonobe Norie, Kataoka Keiko, Suzumura Ayana, Iwase Takeshi, Terasaki Hiroko

    PLOS ONE   Vol. 12 ( 1 ) page: e0170094   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0170094

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  14. Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment

    Tsunekawa Taichi, Kaneko Hiroki, Takayama Kei, Hwang Shiang-Jyi, Oishi Akio, Nagasaka Yosuke, Ye Fuxiang, Iwase Takeshi, Nonobe Norie, Ueno Shinji, Ito Yasuki, Yasuda Shunsuke, Matsuura Toshiyuki, Shimizu Hideyuki, Suzumura Ayana, Kataoka Keiko, Terasaki Hiroko

    BIOMED RESEARCH INTERNATIONAL   Vol. 2017   page: 3427319   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2017/3427319

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  15. Increased Retinal Thinning after Combination of Internal Limiting Membrane Peeling and Silicone Oil Endotamponade in Proliferative Diabetic Retinopathy

    Kaneko Hiroki, Matsuura Toshiyuki, Takayama Kei, Ito Yasuki, Iwase Takeshi, Ueno Shinji, Nonobe Norie, Yasuda Shunsuke, Kataoka Keiko, Terasaki Hiroko

    OPHTHALMOLOGICA   Vol. 238 ( 4 ) page: 226-235   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000479482

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  16. Effect of blue light-filtering intraocular lens on color vision in patients with macular diseases after vitrectomy Reviewed

    Mokuno Kumiko, Asami Tetsu, Nonobe Norie, Ito Hirotaka, Fujiwara Kumi, Terasaki Hiroko

    INTERNATIONAL OPHTHALMOLOGY   Vol. 36 ( 6 ) page: 829 - 839   2016.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10792-016-0214-7

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  17. Comparisons of optical coherence tomography angiography and fluorescein angiography in detecting neovascularization and capillary nonperfused areas in eyes with diabetic retinopathy Reviewed

    Ito Yasuki, Iwase Takeshi, Yasuda Shunsuke, Asami Tetsu, Nonobe Norie, Akahori Tomohiko, Okado Satoshi, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 57 ( 12 )   2016.9

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  18. Increased Ocular Levels of MicroRNA-148a in Cases of Retinal Detachment Promote Epithelial-Mesenchymal Transition Reviewed

    Takayama Kei, Kaneko Hiroki, Hwang Shiang-Jyi, Ye Fuxiang, Higuchi Akiko, Tsunekawa Taichi, Matsuura Toshiyuki, Iwase Takeshi, Asami Tetsu, Ito Yasuki, Ueno Shinji, Yasuda Shunsuke, Nonobe Norie, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 57 ( 6 ) page: 2699 - 2705   2016.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.15-18660

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  19. Nuclear Factor (Erythroid-Derived)-Related Factor 2-Associated Retinal Pigment Epithelial Cell Protection under Blue Light-Induced Oxidative Stress Reviewed

    Takayama Kei, Kaneko Hiroki, Kataoka Keiko, Kimoto Reona, Hwang Shiang-Jyi, Ye Fuxiang, Nagasaka Yosuke, Tsunekawa Taichi, Matsuura Toshiyuki, Nonobe Norie, Ito Yasuki, Terasaki Hiroko

    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY   Vol. 2016   page: 8694641   2016

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2016/8694641

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  20. Buckling surgery and supplemental intravitreal bevacizumab or photocoagulation on stage 4 retinopathy of prematurity eyes Reviewed

    Futamura Yukiko, Asami Tetsu, Nonobe Norie, Kachi Shu, Ito Yasuki, Sato Yoshiaki, Hayakawa Masahiro, Terasaki Hiroko

    JAPANESE JOURNAL OF OPHTHALMOLOGY   Vol. 59 ( 6 ) page: 378 - 388   2015.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10384-015-0401-5

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  21. Consecutive serum vascular endothelial growth factor levels in premature infants Reviewed

    Asami Tetsu, Nonobe Norie, Kaneko Hiroki, Futamura Yukiko, Kimoto Reona, Hirakawa Akihiro, Sato Yoshiaki, Hayakawa Masahiro, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 56 ( 7 )   2015.6

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  22. CONCENTRATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN AQUEOUS HUMOR OF EYES WITH ADVANCED RETINOPATHY OF PREMATURITY BEFORE AND AFTER INTRAVITREAL INJECTION OF BEVACIZUMAB Reviewed

    Nonobe Norie Ito, Kachi Shu, Kondo Mineo, Takai Yoshiko, Takemoto Koji, Nakayama Atsushi, Hayakawa Masahiro, Terasaki Hiroko

    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   Vol. 29 ( 5 ) page: 579 - 585   2009.5

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  23. Concentration of vascular endothelial growth factor in aqueous humor of eyes with advanced retinopathy of prematurity before and after intravitreal injection of bevacizumab. Reviewed

    Nonobe NI, Kachi S, Kondo M, Takai Y, Takemoto K, Nakayama A, Hayakawa M, Terasaki H

    Retina (Philadelphia, Pa.)   Vol. 29 ( 5 ) page: 579 - 85   2009.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/IAE.0b013e3181a3b848

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Books 2

  1. ① 新篇眼科プラクティスシリーズ第3巻 「OCTとOCTAが, わかる, 役立つ !」 

    野々部 典枝( Role: Joint author ,  Ⅲ. 血管性疾患 8. 未熟児網膜症)

    文光堂  2022.4  ( ISBN:978-4-8306-5613-2

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    Language:Japanese Book type:Textbook, survey, introduction

  2. RETINA Medicine

    野々部 典枝( Role: Contributor ,  新しい薬剤、新しい適応 未熟児網膜症(ROP))

    先端医学社  2021.4 

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    Total pages:96   Language:Japanese Book type:General book, introductory book for general audience

Presentations 7

  1. Management of retinopathy of prematurity Invited International conference

    Norie Nonobe

    Fuji Retina  2022.4.24  Japan Retina and Vitreous Society

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    Event date: 2022.4

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  2. 未熟児網膜症に対する網膜光凝固術 Invited

    野々部 典枝

    第126回日本眼科学会総会  2022.4.14  大阪大学

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    Event date: 2022.4

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:大阪  

  3. 未熟児網膜症診療におけるOCT Angiographyの活用 Invited

    野々部 典枝

    第46回小児眼科学会  2021.6.5  産業医科大学

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡  

  4. 小児における眼底画像検査の進歩 Invited

    野々部 典枝

    第126回日本眼科学会総会  2022.4.17  大阪大学

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    Event date: 2022.4

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:大阪  

  5. IVRの実際と短期合併症

    野々部 典枝

    第75回日本臨床眼科学会  2021.10.29  鹿児島大学

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    Event date: 2021.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡  

  6. 未熟児網膜症に対する硝子体注射手技

    野々部 典枝

    第74回日本臨床眼科学会  2020.10.16  金沢大学

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    Event date: 2020.10

    Language:Japanese  

    Venue:東京  

  7. 未熟児網膜症に対する抗VEGF薬治療の実際 Invited

    野々部 典枝

    第76回日本弱視斜視学会総会・第45回日本小児眼科学会総会 合同学会  2020.6.27  日本小児眼科学会

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    Event date: 2020.6

    Language:Japanese  

    Venue:大阪  

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KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. 小児網膜疾患における網膜形態異常に対する多角的解析

    Grant number:18K16922  2018.4 - 2021.3

    若手研究

    野々部 典枝

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    Authorship:Principal investigator 

    Grant amount:\2990000 ( Direct Cost: \2300000 、 Indirect Cost:\690000 )

    本年度は小児の網膜血管疾患であるコーツ病の児に対して、11例11眼のswept source optical coherence tomography(SS-OCT)を撮影し、これまでの検眼鏡検査では不明であった網膜層別の所見について明らかにすることができた。コーツ病では、視力を規定する中心窩に血管からの滲出物が貯留し、それよりも深層の網膜については詳細な状態は滲出物に隠れて観察できなかったが、SS-OCTでは網膜深層の障害などが明瞭に観察可能で、滲出改善後の視力予後について予測できるのではないかと考えられた。現在SS-OCTの所見と視力との関係性について検討中である。さらに、広角で撮影した蛍光眼底造影の画像とOCT Angigraphy (OCTA)で得られた画像を比較し、OCTAがコーツ病の経過観察において疾患活動性の有無を判断するための検査として活用できるかどうかの検証を行っているところである。OCTAが蛍光眼底撮影に代わることができれば、繰り返し撮影する必要があるコーツ病のような血管疾患に対して、造影不要で経過観察が可能となるため、特に小児においては有用と考えている。
    昨年度に主に行っていた未熟児網膜症のSS-OCT、OCTA撮影に関しては、これまでにSS-OCTとOCTAを撮影した児の経過を引き続き経時的に撮影し、初回撮影時の画像との変化を比較している。小児であるため視力が徐々に発育している途上であるが、SS-OCTの所見との視力の関係性について検討しているところである。
    未熟児網膜症については、初回撮影に成功した後も対象の児について経時的に繰り返しSS-OCTとOCTAの両者を撮影することができており、経過観察しながら所見と視力の比較ができていることから、本研究課題はおおむね順調に進展していると考えられる。また、今年度は未熟児網膜症に加えてコーツ病の児についても症例数が増えてきており、所見の比較検討を行える状態となってきている。課題であった撮影時の眼球の位置のコントロールについても、撮影機器の角度の設定と撮影モードの工夫によりある程度コントロール可能な状況となってきており、撮影時の患児の負担についても撮影時間の短縮につながるなど軽減されていると考えられる。
    SS-OCT、OCTA撮影で得られた所見と視力についての関係性を明らかにしたいと考えているが、小児の視力検査は検査当日の児の状態(体調や気分)によって左右されることがあり、成人と違って評価が困難な場合がある。したがって、より客観的な指標で画像所見と網膜機能の関連性を明らかにできる指標が必要であると考えている。具体的には、網膜電図などについて検討している。現在網膜電図は非接触で検査できる機器や網膜の部位別に電位を測定できる機器があり、これを用いて評価できるか今後施行していく予定である。

 

Teaching Experience (On-campus) 1

  1. 眼科学

    2021