Updated on 2026/07/29

写真a

 
NIIMI Kaoru
 
Organization
Graduate School of Medicine Program in Integrated Medicine Medicine in Growth and Aging Associate Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate Professor

Degree 1

  1. 博士(医学) ( 2013.3   名古屋大学 ) 

Research Interests 2

  1. 絨毛性疾患

  2. 婦人科腫瘍

Research Areas 1

  1. Life Science / Obstetrics and gynecology  / gynecologic oncology

Professional Memberships 3

  1. 日本産科婦人科学会

  2. 日本婦人科腫瘍学会

  3. 日本胎盤学会

 

Papers 114

  1. Drug library screening identifies colchicine and shikonin as therapeutic candidates for methotrexate-resistant choriocarcinoma.

    Nishiko Y, Yoshida K, Yokoi A, Kitagawa M, Inami E, Yasui Y, Ishikawa T, Mizushima T, Yoshihara M, Mogi K, Nagao Y, Tamauchi S, Yoshikawa N, Yamamoto E, Niimi K, Kajiyama H

    Biochemical and biophysical research communications   Vol. 831   page: 154317   2026.7

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    Language:English  

    DOI: 10.1016/j.bbrc.2026.154317

    PubMed

  2. Clinical experience with de-escalated chemotherapy for a subset of high-risk gestational trophoblastic neoplasia at a single institution

    Yoshida, K; Yoshida, T; Shirasaki, M; Yasui, Y; Yamamoto, E; Niimi, K; Kajiyama, H

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY     2026.6

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  3. Rapid Enlargement of Vulvar Glomus Tumor After Needle Aspiration and Tumor Base Ligation

    Nagao, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 52 ( 6 ) page: e70373   2026.6

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  4. Therapy-related myeloid neoplasms following treatment for high-risk gestational trophoblastic neoplasia: a case series and retrospective analysis

    Niimi, K; Yamamoto, E; Yoshida, K; Yasui, Y; Kajiyama, H

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 31 ( 8 ) page: 1628 - 1635   2026.6

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  5. Integrated immunophenotypic and ProMisE molecular profiling as predictors of immune checkpoint inhibitor response in recurrent endometrial cancer.

    Katayama K, Yoshikawa N, Liu W, Nakamura K, Hattori S, Kubokawa M, Iyoshi S, Yoshida K, Yoshihara M, Nagao Y, Tamauchi S, Yokoi A, Niimi K, Shimizu Y, Kawai Y, Utsumi F, Watanabe E, Suzuki S, Shibata K, Kajiyama H

    Cancer immunology, immunotherapy : CII     2026.6

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    Language:English  

    DOI: 10.1007/s00262-026-04414-y

    PubMed

  6. Impact of Sarcopenia and Pretreatment Skeletal Muscle Loss on Survival in Endometrial Cancer Patients Treated With Immune Checkpoint Inhibitors.

    Katayama K, Yoshikawa N, Nonoyama K, Hattori S, Yoshida K, Yoshihara M, Tamauchi S, Yokoi A, Niimi K, Kajiyama H

    The journal of obstetrics and gynaecology research   Vol. 52 ( 6 ) page: e70362   2026.6

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    Language:English  

    DOI: 10.1111/jog.70362

    PubMed

  7. Association of germline BRCA and homologous recombination deficiency with hematologic toxicity during platinum-taxane chemotherapy in ovarian cancer

    Yoshida, K; Araki, H; Yamada, Y; Masahashi, Y; Miyamoto, E; Katayama, K; Kubokawa, M; Mogi, K; Yoshihara, M; Nagao, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Niimi, K; Kajiyama, H

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 31 ( 8 ) page: 1576 - 1586   2026.5

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  8. DNA Copy Number Profiling in Extracellular Vesicles as Clinical Biomarkers of High-Grade Serous Ovarian Carcinoma

    Uekusa, R; Yokoi, A; Ukai, M; Yoshida, K; Chattrairat, K; Yasui, T; Inokuma, Y; Kitagawa, M; Asano-Inami, E; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Niimi, K; Matsuzaki, J; Ochiya, T; Sood, AK; Yamamoto, Y; Kajiyama, H

    JOURNAL OF EXTRACELLULAR VESICLES   Vol. 15 ( 5 ) page: e70308   2026.5

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  9. In-Tumor CRISPR-Cas9 Knockout Screening and Novel Therapy Development for Malignant Transformation of Ovarian Teratoma Open Access

    Tamauchi, S; Yoshida, K; Xinyuan, W; Nakagawa, A; Yokoi, A; Yoshikawa, N; Niimi, K; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 117 ( 4 ) page: 983 - 995   2026.4

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  10. Small-cell carcinoma of the cervix with acute-onset psychotic symptoms associated with clinically diagnosed ectopic ACTH production: a case report

    Ozaki, K; Fujino, J; Niimi, K; Iwata-Endo, K; Otsuka, N; Kobayashi, T; Yoshida, K; Mogi, K; Yoshihara, M; Nagao, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Kajiyama, H

    FRONTIERS IN ONCOLOGY   Vol. 16   page: 1684861   2026.3

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  11. Mesothelial cells promote peritoneal invasion and metastasis of ascites-derived ovarian cancer cells through spheroid formation Open Access

    Uno, K; Yoshihara, M; Yamakita, Y; Kitami, K; Iyoshi, S; Sugiyama, M; Koya, Y; Kanayama, T; Sahara, H; Nomura, S; Mogi, K; Miyamoto, E; Fujimoto, H; Yoshida, K; Tamauchi, S; Yokoi, A; Yoshikawa, N; Niimi, K; Shiraki, Y; Sjölund, J; Oguchi, H; Pietras, K; Enomoto, A; Nawa, A; Tomita, H; Kajiyama, H

    SCIENCE ADVANCES   Vol. 12 ( 6 ) page: eadu5944   2026.2

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  12. Natural-killer-cell-dominant immune landscape and HLA-E-mediated immune evasion in choriocarcinoma Open Access

    Shibata, M; Yoshida, K; Yasui, Y; Nishiko, Y; Hattori, S; Nakamura, K; Koya, Y; Yamamoto, Y; Suzuki, K; Yoshihara, M; Nagao, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nishino, K; Yamamoto, E; Niimi, K; Kajiyama, H

    PLACENTA   Vol. 174   page: 9 - 18   2026.2

  13. Real-world data-based assessment of therapy-related myeloid neoplasms after poly(ADP-ribose) polymerase inhibitor treatment in ovarian cancer Open Access

    Uekusa, R; Yokoi, A; Watanabe, E; Inoue, M; Mizuno, K; Yoshida, K; Yoshikawa, N; Niimi, K; Suzuki, S; Kajiyama, H

    FRONTIERS IN ONCOLOGY   Vol. 16   page: 1728766   2026.1

  14. Risk factors for recurrent cases of early-stage uterine sarcoma after complete surgical resection Open Access

    Nagao, Y; Yokoi, A; Yoshida, K; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Niimi, K; Kajiyama, H

    BMC CANCER   Vol. 26 ( 1 )   2026.1

  15. Diagnostic Use of the Combination of CA72-4 and Tumor Volume in Mucinous Ovarian Tumors

    Araki, H; Yokoi, A; Kuroda, K; Suzuki, K; Yoshida, K; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 52 ( 1 ) page: e70177   2026.1

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  16. Application of EV sheets to realize ideal extracellular vesicle biomarker development in ovarian cancer

    Nagao, Y; Yokoi, A; Yoshida, K; Kitagawa, M; Inami, E; Suzuki, K; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Niimi, K; Yasui, T; Kajiyama, H; Otani, N; Takahashi, C; Kohno, T; Fujita, Y; Totsuka, Y; Nannya, Y; Kiyokawa, E; Gotoh, N

    CANCER SCIENCE   Vol. 117   page: 165 - 165   2026.1

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  17. Investigation of Choriocarcinoma-Associated miRNAs Through Small RNA Sequencing

    Yoshida, K; Iyoshi, S; Mogi, K; Yoshihara, M; Nagao, Y; Tamauchi, S; Yokoi, A; Niimi, K; Kajiyama, H

    CANCER SCIENCE   Vol. 117   page: 2132 - 2132   2026.1

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  18. Unveiling a Novel Role of Mesothelial Glycocalyx in Peritoneal Metastasis of Ovarian Cancer

    Mogi, K; Yoshikawa, M; Kunishima, A; Miyamoto, E; Koya, Y; Yamakita, Y; Fujimoto, H; Iyoshi, S; Yoshida, K; Yoshihara, M; Nagao, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Niimi, K; Kajiyama, H

    CANCER SCIENCE   Vol. 117   page: 1196 - 1196   2026.1

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  19. Genomic insights and therapeutic efficacy of PARP inhibitors in a high-LOH patient-derived xenograft from malignant transformation of ovarian teratoma Open Access

    Nakagawa, A; Tamauchi, S; Xinyuan, W; Yoshida, K; Yokoi, A; Yoshikawa, N; Niimi, K; Kajiyama, H

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 792   page: 152979   2025.12

  20. Downregulation of Chromosome 19 miRNA Cluster and the Tumor-Suppressive Role of miR-517a-3p in Choriocarcinoma Open Access

    Nishiko, Y; Yoshida, K; Yasui, Y; Yokoi, A; Kitagawa, M; Inami, E; Yoshihara, M; Mogi, K; Nagao, Y; Tamauchi, S; Yoshikawa, N; Nishino, K; Yamamoto, E; Niimi, K; Kajiyama, H

    CANCER SCIENCE   Vol. 116 ( 12 ) page: 3473 - 3486   2025.12

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  21. GLOBAL PHASE II STUDY OF RISOVALISIB, A SELECTIVE PI3Kα INHIBITOR, AS MONOTHERAPY IN PATIENTS WITH RECURRENT/PERSISTENT OVARIAN CLEAR CELL CARCINOMA HARBORING PIK3CA HOTSPOT MUTATIONS

    Wu, XH; Yonemori, K; Niimi, K; Nakagawa, S; Li, JJ; Liu, JH; Yoshihara, K; Shigeta, S; Zhu, JQ; Qiu, H; Tang, J; Watar, H; Chiyoda, T; Nagao, S; Liang, ZQ; Meng, YG; Zhou, HM; An, RF; Okamoto, A; Nishio, S; Takehara, K; Hamanishi, J; Yao, SZ; Xue, FX; Lou, G; Pan, HM; Chen, WJ; Yin, RT; Duan, W; Shimada, M

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 35 ( 11 )   2025.11

  22. Application of multimodal integration to develop preoperative diagnostic models for borderline and malignant ovarian tumors

    Kunishima, A; Inaba, D; Iyoshi, S; Ikeda, Y; Goto, M; Muramatsu, R; Hashimoto, M; Yoshida, K; Mogi, K; Yoshihara, M; Nagao, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Niimi, K; Koizumi, N; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 15 ( 1 ) page: 37114   2025.10

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  23. Proteomic Profiling of Bacterial Extracellular Vesicles for Exploring Ovarian Cancer Biomarkers Open Access

    Asano-Inami, E; Yokoi, A; Yoshida, K; Taki, K; Kitagawa, M; Suzuki, K; Uekusa, R; Nagao, Y; Yoshikawa, N; Niimi, K; Yamamoto, Y; Kajiyama, H

    JOURNAL OF EXTRACELLULAR BIOLOGY   Vol. 4 ( 10 ) page: e70073   2025.10

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  24. Outcomes of cases with complete hydatidiform mole coexisting with a fetus: a single-center study Open Access

    Niimi, K; Shibata, M; Yoshida, K; Yamamoto, E; Sumigama, S; Yasui, Y; Nishiko, Y; Nishino, K; Kajiyama, H

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 30 ( 9 ) page: 1866 - 1872   2025.9

  25. Overcoming platinum-resistant ovarian cancer targeting the activated JAK-STAT pathways via extracellular vesicles Open Access

    Suzuki, K; Yokoi, A; Yoshida, K; Suzuki, H; Kitagawa, M; Asano-Inami, E; Matsuo, S; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Niimi, K; Sudo, T; Yamaguchi, S; Yamamoto, Y; Kajiyama, H

    COMMUNICATIONS BIOLOGY   Vol. 8 ( 1 ) page: 1305   2025.8

  26. Development and Validation of Predictive Risk Scores for Ovarian Clear Cell Carcinoma: A Penalized Regression Model

    Iyoshi, S; Emoto, R; Yoshikawa, N; Yoshida, K; Yoshihara, M; Tamauchi, S; Yokoi, A; Shimizu, Y; Ikeda, Y; Niimi, K; Kawai, M; Matsui, S; Kajiyama, H

    CANCER MEDICINE   Vol. 14 ( 15 ) page: e71118   2025.8

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  27. Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer Open Access

    Miyamoto, E; Yoshihara, M; Iyoshi, S; Mogi, K; Uno, K; Fujimoto, H; Koya, Y; Kitami, K; Yoshida, K; Tamauchi, S; Yokoi, A; Yoshikawa, N; Niimi, K; Tomita, H; Kidoya, H; Shiraki, Y; Enomoto, A; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 15 ( 1 ) page: 23196   2025.7

  28. Tumor growth direction predicts surgical difficulty in large uterine fibroids: A retrospective imaging-based study

    Tamauchi, S; Niimi, K; Iyoshi, S; Yoshida, K; Mogi, K; Yoshihara, M; Nagao, Y; Yokoi, A; Yoshikawa, N; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 51 ( 7 ) page: e70013   2025.7

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  29. Long-term prognostic significance of ascites cytology in ovarian cancer cases in which R0 resection was achieved in the initial surgery: a multi-institutional retrospective cohort study Open Access

    Iyoshi, S; Sunohara, M; Yoshihara, M; Kunishima, A; Miyamoto, E; Fujimoto, H; Kitami, K; Mogi, K; Uno, K; Yoshida, K; Tamauchi, S; Yokoi, A; Niimi, K; Yoshikawa, N; Emoto, R; Matsui, S; Kajiyama, H

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 55 ( 7 ) page: 743 - 750   2025.7

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  30. Two cases of drug-resistant gestational trophoblastic neoplasia treated with immune checkpoint inhibitor

    Katayama, E; Usui, H; Nakamura, N; Ohira, G; Matsuzaka, K; Ikeda, JI; Niimi, K; Kagami, K; Fujiwara, H; Koga, K

    JOURNAL OF REPRODUCTIVE IMMUNOLOGY   Vol. 169   2025.6

  31. Utility of manual vacuum aspiration followed by curettage in the treating hydatidiform mole: A retrospective analysis Open Access

    Aoki, U; Yoshida, K; Yasui, Y; Nishiko, Y; Yokoi, A; Yoshikawa, N; Nishino, K; Yamamoto, E; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 51 ( 1 ) page: e16210   2025.1

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  32. Understanding the impact of spatial immunophenotypes on the survival of endometrial cancer patients through the ProMisE classification Open Access

    Hattori, S; Yoshikawa, N; Liu, WT; Matsukawa, T; Kubokawa, M; Yoshida, K; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Shimizu, Y; Niimi, K; Kajiyama, H

    CANCER IMMUNOLOGY IMMUNOTHERAPY   Vol. 74 ( 2 ) page: 70   2025.1

  33. Development of an early diagnosis system for ovarian tumors using Artificial Intelligence

    Kunishima, A; Ikeda, Y; Inaba, D; Koizumi, N; Goto, M; Muramatsu, R; Hashimoto, M; Iyoshi, S; Yoshida, K; Mogi, K; Yoshihara, M; Tamauchi, S; Yokoi, A; Yoshikawa, N; Niimi, K; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 70 - 70   2025.1

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  34. Risk Factors for Acute Hemorrhagic Rectal Ulcers after Bypass Surgery for Chronic Limb-Threatening Ischemia

    Kawai, Y; Sugimoto, M; Osawa, T; Lee, C; Ikeda, S; Niimi, K; Banno, H

    ANNALS OF VASCULAR DISEASES   Vol. 18 ( 1 )   2025

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  35. Elucidation of the role of XBP1 in the progression of complete hydatidiform mole to invasive mole through RNA-seq Open Access

    Shibata, M; Yoshida, K; Yokoi, A; Suzuki, H; Yamamoto, Y; Kitagawa, M; Asano-Inami, E; Yasui, Y; Nishiko, Y; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Nishino, K; Yamamoto, E; Niimi, K; Kajiyama, H

    GYNECOLOGIC ONCOLOGY   Vol. 190   page: 189 - 199   2024.11

  36. Update on the oncologic and obstetric outcomes of medroxyprogesterone acetate treatment for atypical endometrial hyperplasia and endometrial cancer

    Tamauchi, S; Nakagawa, A; Yoshida, K; Yoshihara, M; Yokoi, A; Yoshikawa, N; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 9 ) page: 1614 - 1621   2024.9

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  37. Spatial distribution of tumor-resident macrophages as predictive biomarkers in endometrial cancer Open Access

    Matsukawa, T; Yoshikawa, N; Liu, WT; Hattori, S; Yoshida, K; Yoshihara, M; Tamauchi, S; Yokoi, A; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 7 ) page: 1141 - 1147   2024.7

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  38. Combined use of tyrosine kinase inhibitors with PD-(L)1 blockade increased the risk of thyroid dysfunction in PD-(L)1 blockade: a prospective study

    Kobayashi, T; Iwama, S; Yamagami, A; Izuchi, T; Suzuki, K; Otake, K; Yasuda, Y; Ando, M; Onoue, T; Miyata, T; Sugiyama, M; Hagiwara, D; Suga, H; Banno, R; Hase, T; Nishio, N; Mori, S; Shimokata, T; Sano, T; Niimi, K; Yoshikawa, N; Akamatsu, S; Ando, Y; Akiyama, M; Sone, M; Ishii, M; Arima, H

    CANCER IMMUNOLOGY IMMUNOTHERAPY   Vol. 73 ( 8 ) page: 146   2024.6

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  39. Safety assessments and clinical features of PARP inhibitors from real-world data of Japanese patients with ovarian cancer Open Access

    Uekusa, R; Yokoi, A; Watanabe, E; Yoshida, K; Yoshihara, M; Tamauchi, S; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Niimi, K; Suzuki, S; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 14 ( 1 ) page: 12595   2024.6

  40. Real-world data of poly (ADP-ribose) polymerase inhibitor response in Japanese patients with ovarian cancer Open Access

    Uekusa, R; Yokoi, A; Watanabe, E; Yoshida, K; Yoshihara, M; Tamauchi, S; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Niimi, K; Suzuki, S; Kajiyama, H

    CANCER MEDICINE   Vol. 13 ( 7 ) page: e7149   2024.4

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  41. Effect of radical trachelectomy on ovarian reserve: A single-institute prospective study

    Nakagawa, A; Tamauchi, S; Sato, M; Yoshihara, M; Yokoi, A; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Niimi, K; Osuka, S; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 2 ) page: 212 - 217   2024.2

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  42. An update of oncologic and obstetric outcomes of radical trachelectomy for early-stage cervical cancer: The need for further minimally invasive treatment

    Tamauchi, S; Iyoshi, S; Yoshihara, M; Yoshida, K; Ikeda, Y; Shimizu, Y; Yokoi, A; Niimi, K; Yoshikawa, N; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 2 ) page: 175 - 181   2024.2

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  43. Mean platelet volume as a potential biomarker for survival outcomes in ovarian clear cell carcinoma

    Yoshikawa, N; Matsukawa, T; Hattori, S; Iyoshi, S; Yoshida, K; Yoshihara, M; Tamauchi, S; Shimizu, Y; Ikeda, Y; Yokoi, A; Niimi, K; Kawai, M; Kajiyama, H

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 28 ( 12 ) page: 1680 - 1689   2023.12

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  44. Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model Open Access

    Oda, Y; Niimi, K; Yoshida, K; Tamauchi, S; Yokoi, A; Yasui, Y; Nishiko, Y; Shibata, M; Shimizu, Y; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Yamamoto, E; Kajiyama, H

    BMC CANCER   Vol. 23 ( 1 ) page: 1103   2023.11

  45. 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins Open Access

    Mogi, K; Koya, Y; Yoshihara, M; Sugiyama, M; Miki, R; Miyamoto, E; Fujimoto, H; Kitami, K; Iyoshi, S; Tano, S; Uno, K; Tamauchi, S; Yokoi, A; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Niimi, K; Yamakita, Y; Tomita, H; Shibata, K; Nawa, A; Tomoda, Y; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 19208   2023.11

  46. A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab Open Access

    Niimi, K; Yamamoto, E; Oda, Y; Nishiko, Y; Shibata, M; Nishino, K; Kajiyama, H

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 62 ( 5 ) page: 745 - 748   2023.9

  47. Niraparib as a therapeutic agent for the treatment of ovarian cancer meningeal dissemination with <i>BRCA1</i> mutation Open Access

    Nei, T; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 7 ) page: 1875 - 1879   2023.7

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  48. Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma Reviewed Open Access

    Watanabe, E; Yokoi, A; Yoshida, K; Sugiyama, M; Kitagawa, M; Nishino, K; Yamamoto, E; Niimi, K; Yamamoto, Y; Kajiyama, H

    CANCER MEDICINE   Vol. 12 ( 4 ) page: 4543 - 4556   2023.2

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  49. Identifying Copy Number Variations in Extracellular Vesicles as a Novel Biomarker of High Grade Serous Ovarian Carcinoma

    Uekusa, R; Yokoi, A; Kitagawa, M; Yoshida, K; Yoshihara, M; Tamauchi, S; Niimi, K; Matsuzaki, J; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 1063 - 1063   2023.2

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  50. The prognostic significance of DDIT4 in endometrial cancer

    Yoshikawa, N; Yoshida, K; Liu, WT; Matsukawa, T; Hattori, S; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Shimizu, Y; Niimi, K; Kajiyama, H

    CANCER BIOMARKERS   Vol. 37 ( 4 ) page: 217 - 225   2023

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  51. Epidemiologic study on gestational trophoblastic diseases in Japan Reviewed Open Access

    Yamamoto, E; Nishino, K; Niimi, K; Ino, K

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 33 ( 6 ) page: e72   2022.11

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  52. Is cystectomy an option as conservative surgery for young patients with borderline ovarian tumor? A multi-institutional retrospective study Reviewed

    Ikeda, Y; Yoshihara, M; Yoshikawa, N; Tamauchi, S; Yokoi, A; Nishino, K; Niimi, K; Kajiyama, H

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 157 ( 2 ) page: 437 - 443   2022.5

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  53. Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis Reviewed Open Access

    Kitami, K; Yoshihara, M; Tamauchi, S; Sugiyama, M; Koya, Y; Yamakita, Y; Fujimoto, H; Iyoshi, S; Uno, K; Mogi, K; Ikeda, Y; Yokoi, A; Yoshikawa, N; Nishino, K; Niimi, K; Nawa, A; Enomoto, A; Kajiyama, H

    MATRIX BIOLOGY   Vol. 109   page: 70 - 90   2022.5

  54. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

    Iwama, S; Kobayashi, T; Yasuda, Y; Okuji, T; Ito, M; Ando, M; Zhou, X; Yamagami, A; Onoue, T; Kawaguchi, Y; Miyata, T; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Hase, T; Morise, M; Wakahara, K; Yokota, K; Kato, M; Nishio, N; Tanaka, C; Miyata, K; Ogura, A; Ito, T; Sawada, T; Shimokata, T; Niimi, K; Ohka, F; Ishigami, M; Gotoh, M; Hashimoto, N; Saito, R; Kiyoi, H; Kajiyama, H; Ando, Y; Hibi, H; Sone, M; Akiyama, M; Kodera, Y; Arima, H

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   Vol. 107 ( 4 ) page: E1620 - E1630   2022.3

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  55. Is adjuvant chemotherapy necessary for young women with early-stage epithelial ovarian cancer who have undergone fertility-sparing surgery?: a multicenter retrospective analysis

    Ikeda, Y; Yoshihara, M; Yoshikawa, N; Yokoi, A; Tamauchi, S; Nishino, K; Niimi, K; Kajiyama, H

    BMC WOMENS HEALTH   Vol. 22 ( 1 ) page: 80   2022.3

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  56. Vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer via THBS1

    Kitami, K; Yoshihara, M; Sugiyama, M; Koya, Y; Yamakita, Y; Iyoshi, S; Uno, K; Mogi, K; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nishino, K; Niimi, K; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 113   page: 729 - 729   2022.2

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  57. Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma

    Nishino, K; Nishiko, Y; Shibata, M; Oda, Y; Watanabe, E; Niimi, K; Yamamoto, E; Kajiyama, H

    PLACENTA   Vol. 117   page: 109 - 117   2022.1

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  58. Laparoscopic pelvic surgery after reconstructive surgery with vertical rectus abdominis muscle flap: A case report

    Nishino, K; Ikeda, Y; Kitami, K; Niimi, K; Kajiyama, H

    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS   Vol. 90   page: 106706   2022.1

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  59. Clinical effects of cervical conization with positive margins in cervical cancer

    Nagao, Y; Yokoi, A; Yoshida, K; Sumi, M; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 23288   2021.12

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  60. The current situation of health services for hydatidiform mole in Cambodia

    Yamamoto, E; Kanal, K; Soeung, SC; Fujita, N; Krang, S; Long-Hay, P; Nishino, K; Niimi, K; Hamajima, N

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 10 ) page: 3652 - 3660   2021.10

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  61. Short tandem repeat analysis to identify the causative pregnancy of high-risk gestational trophoblastic neoplasia: Molar versus nonmolar pregnancy and its relation to the outcome

    Nishino, K; Yamamoto, E; Oda, Y; Watanabe, E; Niimi, K; Yamamoto, T; Kajiyama, H

    PLACENTA   Vol. 112   page: 28 - 35   2021.9

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  62. Next-generation genome sequencing of a matched normal-tumor pair from a patient with intractable gestational choriocarcinoma: A case report Open Access

    Niimi, K; Yamamoto, E; Morita, S; Morikawa, M; Hattori, H; Hatakeyama, M; Morita, M; Nishino, K; Oda, Y; Watanabe, E; Yamamoto, T; Kajiyama, H; Kikkawa, F

    MOLECULAR AND CLINICAL ONCOLOGY   Vol. 15 ( 1 ) page: 143   2021.7

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  63. Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity

    Nakamura, K; Niimi, K; Yamamoto, E; Ikeda, Y; Nishino, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    BIOCHEMISTRY AND BIOPHYSICS REPORTS   Vol. 26   page: 100951   2021.7

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  64. Metabolome analysis reveals a diversity of cancer tissues in advanced epithelial ovarian cancer

    Yoshida, K; Yoshikawa, N; Kitami, K; Tamauchi, S; Ikeda, Y; Yokoi, A; Nishino, K; Niimi, K; Kajiyama, H

    CANCER CELL INTERNATIONAL   Vol. 21 ( 1 ) page: 314   2021.6

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  65. Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer

    Hattori, S; Yoshikawa, N; Mogi, K; Yoshida, K; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Nishino, K; Niimi, K; Suzuki, S; Kajiyama, H

    CURRENT ONCOLOGY   Vol. 28 ( 3 ) page: 1663 - 1672   2021.6

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  66. Assessment of myocardial performance index in late-onset fetal growth restriction

    Nguyen, TTN; Kotani, T; Imai, K; Ushida, T; Moriyama, Y; Kobayashi, T; Niimi, K; Sumigama, S; Yamamoto, E; Vo, VD; Le, MT; Le, LH; Nguyen, DN; Nguyen, VQH; Truong, QV; Cao, NT; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 2 ) page: 259 - 268   2021.5

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  67. A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review

    Nishino, K; Yamamoto, E; Ikeda, Y; Niimi, K; Yamamoto, T; Kajiyama, H

    JOURNAL OF OVARIAN RESEARCH   Vol. 14 ( 1 ) page: 56   2021.4

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  68. Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance

    Yoshida, K; Yokoi, A; Sugiyama, M; Oda, S; Kitami, K; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F; Yokoi, T; Kajiyama, H

    ONCOGENE   Vol. 40 ( 7 ) page: 1255 - 1268   2021.2

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  69. The role of chrXq27.3 miRNA cluster in advanced ovarian clear cell carcinoma

    Yoshida, K; Yokoi, A; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Nishino, K; Niimi, K; Kikkawa, F; Kajiyama, H

    CANCER SCIENCE   Vol. 112   page: 291 - 291   2021.2

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  70. Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis.

    Muraoka A, Osuka S, Kiyono T, Suzuki M, Yokoi A, Murase T, Nishino K, Niimi K, Nakamura T, Goto M, Kajiyama H, Kondo Y, Kikkawa F

    F&S science   Vol. 1 ( 2 ) page: 195 - 205   2020.11

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    DOI: 10.1016/j.xfss.2020.09.001

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  71. The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study.

    Yamamoto E, Trinh TD, Sekiya Y, Tamakoshi K, Nguyen XP, Nishino K, Niimi K, Kotani T, Kajiyama H, Shibata K, Le QT, Kikkawa F

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 183 - 191   2020.5

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    DOI: 10.18999/nagjms.82.2.183

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  72. The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma

    Yoshikawa, N; Yoshida, K; Tamauchi, S; Ikeda, Y; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 7135   2020.4

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  73. The Therapeutic Effects of Goreisan, a Traditional Japanese Herbal Medicine, on Lower-Limb Lymphedema after Lymphadenectomy in Gynecologic Malignancies: A Case Series Study

    Yoshikawa, N; Kajiyama, H; Otsuka, N; Tamauchi, S; Ikeda, Y; Nishino, K; Niimi, K; Suzuki, S; Utsumi, F; Shibata, K; Kikkawa, F

    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE   Vol. 2020   page: 6298293   2020.4

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  74. Is standard radical surgery necessary for elderly patients with early-stage epithelial ovarian carcinoma? ∼Propensity score matched analysis∼

    Kajiyama, H; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Niimi, K; Suzuki, S; Shibata, K; Kikkawa, F

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 50 ( 4 ) page: 411 - 418   2020.4

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  75. The role of additional hysterectomy after concurrent chemoradiation for patients with locally advanced cervical cancer

    Yoshida, K; Kajiyama, H; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 2 ) page: 384 - 390   2020.2

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  76. Clinical Significance of Ubiquitin-associated Protein 2-like in Patients With Uterine Cervical Cancer

    Yoshida, K; Kajiyama, H; Inami, E; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Shibata, K; Nawa, A; Kikkawa, F

    IN VIVO   Vol. 34 ( 1 ) page: 109 - 116   2020.1

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  77. Impact of age on clinicopathological features and survival of epithelial ovarian neoplasms in reproductive age

    Hanatani, M; Yoshikawa, N; Yoshida, K; Tamauchi, S; Ikeda, Y; Nishino, K; Niimi, K; Suzuki, S; Kawai, M; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 187 - 194   2020.1

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  78. The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia

    Sato, S; Yamamoto, E; Niimi, K; Ino, K; Nishino, K; Suzuki, S; Kotani, T; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 203 - 209   2020.1

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  79. Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma

    Shimbo, A; Kajiyama, H; Tamauchi, S; Yoshikawa, N; Ikeda, Y; Nishino, K; Suzuki, S; Niimi, K; Sakata, J; Kikkawa, F

    ONCOLOGY REPORTS   Vol. 42 ( 6 ) page: 2323 - 2332   2019.12

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  80. Unique miRNA profiling of squamous cell carcinoma arising from ovarian mature teratoma: comprehensive miRNA sequence analysis of its molecular background

    Yoshida, K; Yokoi, A; Kagawa, T; Oda, S; Hattori, S; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Shibata, K; Kajiyama, H; Yokoi, T; Kikkawa, F

    CARCINOGENESIS   Vol. 40 ( 12 ) page: 1435 - 1444   2019.12

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  81. COMPREHENSIVE MIRNA SEQUENCING OF SQUAMOUS CELL CARCINOMA ARISING FROM OVARIAN MATURE TERATOMA

    Yoshida, K; Yokoi, A; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A544 - A545   2019.11

  82. Prognostic value of neutrophil-to-lymphocyte ratio in early-stage ovarian clear-cell carcinoma

    Yoshida, K; Yoshikawa, N; Shirakawa, A; Niimi, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 30 ( 6 ) page: e85   2019.11

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  83. REDUCED RESPONSE TO CONTROLLED OVARIAN STIMULATION AFTER RADICAL TRACHELECTOMY

    Tamauchi, S; Kajiyama, H; Osuka, S; Moriyama, Y; Yoshihara, M; Iyoshi, S; Yoshida, K; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A269 - A270   2019.11

  84. Relationship between preexisting mental disorders and prognosis of gynecologic cancers: A case-control study

    Tamauchi, S; Kajiyama, H; Moriyama, Y; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 45 ( 10 ) page: 2082 - 2087   2019.10

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  85. IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery

    Albrecht, C; Chamley, L; Charnock-Jones, DS; Collins, S; Fujiwara, H; Golos, T; Grayo, S; Hannan, N; Harris, L; Ichizuka, K; Illsley, NP; Iwashita, M; Kallol, S; Al-Khan, A; Lash, G; Nagamatsu, T; Nakashima, A; Niimi, K; Nomoto, M; Redman, C; Saito, S; Tanimura, K; Tomi, M; Usui, H; Vatish, M; Wolfe, B; Yamamoto, E; O'Tierney-Ginn, P

    PLACENTA   Vol. 84   page: 9 - 13   2019.9

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  86. Long-term oncologic outcome and its prognostic indicators in reproductive-age women with ovarian clear-cell carcinoma

    Kajiyama, H; Suzuki, S; Yoshikawa, N; Niimi, K; Kawai, M; Shibata, K; Kikkawa, F

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 300 ( 3 ) page: 717 - 724   2019.9

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  87. Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma

    Kajiyama, H; Suzuki, S; Utsumi, F; Yoshikawa, N; Nishino, K; Ikeda, Y; Niimi, K; Yamamoto, E; Kawai, M; Shibata, K; Nagasaka, T; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 8 ) page: 950 - 956   2019.8

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  88. Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia

    Iriyama, T; Wang, G; MidoriYoshikawa; Mimura, N; Matsui, H; Sayama, S; Kumasawa, K; Nagamatsu, T; Koga, K; Kotani, T; Niimi, K; Yamamoto, E; Kellems, RE; Xia, Y; Osuga, Y; Fujii, T

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 10107   2019.7

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  89. Oncologic and reproductive outcomes of cystectomy as a fertility-sparing treatment for early-stage epithelial ovarian cancer

    Kajiyama, H; Suzuki, S; Niimi, K; Tamauchi, S; Kawai, M; Nagasaka, T; Shibata, K; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 7 ) page: 857 - 862   2019.7

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  90. Does postoperative prophylactic irradiation of para-aortic lymph nodes reduce the risk of recurrence in uterine cervical cancer with positive pelvic lymph nodes?

    Yoshida, K; Kajiyama, H; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 5 ) page: 567 - 574   2019.5

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  91. Epidemiological overview of metastatic ovarian carcinoma: long-term experience of TOTSG database

    Kajiyama, H; Suzuki, S; Utsumi, F; Nishino, K; Niimi, K; Mizuno, M; Yoshikawa, N; Kawai, M; Oguchi, H; Mizuno, K; Yamamuro, O; Shibata, K; Nagasaka, T; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 193 - 198   2019.5

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  92. Endometriosis and cancer

    Kajiyama, H; Suzuki, S; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Niimi, K; Shibata, K; Kikkawa, F

    FREE RADICAL BIOLOGY AND MEDICINE   Vol. 133   page: 186 - 192   2019.3

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  93. The role of E2F8 in the human placenta

    Mizuno, M; Miki, R; Moriyama, Y; Ushida, T; Imai, K; Niimi, K; Nakano, T; Tsuda, H; Sumigama, S; Yamamoto, E; Senga, T; Iwase, A; Kikkawa, F; Kotani, T

    MOLECULAR MEDICINE REPORTS   Vol. 19 ( 1 ) page: 293 - 301   2019.1

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  94. LIGHT elevation underlies the sFlt-1 overproduction in patients with hydatidiform mole: An implication for the link between molar pregnancy and preeclampsia

    Matsui, H; Iriyama, T; Wang, G; Yoshikawa, M; Niimi, K; Yamamoto, E; Kotani, T; Nagamatsu, T; Koga, K; Osuga, Y; Fujii, T

    JOURNAL OF REPRODUCTIVE IMMUNOLOGY   Vol. 130   page: 38 - 38   2018.11

  95. Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study

    Tamauchi, S; Kajiyama, H; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Kikkawa, F

    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY   Vol. 219 ( 4 ) page: 385.e1 - 385.e7   2018.10

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  96. EFFECT OF CONCURRENT CHEMO-RADIOTHERAPY ON CLINICAL OUTCOMES IN SMALL CELL CARCINOMA OF THE UTERINE CERVIX

    Ikeda, Y; Kajiyama, H; Yoshida, K; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Kawai, M; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 294 - 294   2018.9

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  97. GENETIC STUDY ON ORIGINS OF CHORIOCARCINOMAS BY SHORT TANDEM REPEAT ANALYSIS

    Nishino, K; Nakamura, K; Ikeda, Y; Niimi, K; Yamamoto, E; Yamamoto, T; Kikkawa, F

    PLACENTA   Vol. 69   page: E88 - E89   2018.9

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  98. SHORT TANDEM REPEAT ANALYSIS DISTINGUISHING THE GENOTYPE OF CHORIOARCINOMA

    Nishino, K; Yamamoto, E; Watanabe, E; Nakamura, K; Ikeda, Y; Niimi, K; Yamamoto, T; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 920 - 920   2018.9

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  99. PROPENSITY SCORE ADJUSTED ANALYSIS OF PROPHYLACTIC IRRADIATION TO PARA-AORTIC LYMPH NODE AFTER RADICAL HYSTERECTOMY FOR UTERINE CERVICAL CANCER.

    Yoshida, K; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Utumi, F; Niimi, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 447 - 447   2018.9

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  100. KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear-cell carcinoma cells

    Kawai, Y; Shibata, K; Sakata, J; Suzuki, S; Utsumi, F; Niimi, K; Sekiya, R; Senga, T; Kikkawa, F; Kajiyama, H

    ONCOLOGY REPORTS   Vol. 40 ( 1 ) page: 195 - 205   2018.7

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  101. The upregulated expression of vascular endothelial growth factor in surgically treated patients with recurrent/radioresistant cervical cancer of the uterus

    Yoshida, K; Suzuki, S; Sakata, J; Utsumi, F; Niimi, K; Yoshikawa, N; Nishino, K; Shibata, K; Kikkawa, F; Kajiyama, H

    ONCOLOGY LETTERS   Vol. 16 ( 1 ) page: 515 - 521   2018.7

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  102. Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary.

    Yoshikawa N, Teshigawara T, Ikeda Y, Nishino K, Sakata J, Utsumi F, Niimi K, Sekiya R, Suzuki S, Kawai M, Shibata K, Kikkawa F, Kajiyama H

    Oncotarget   Vol. 9 ( 44 ) page: 27564 - 27573   2018.6

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    DOI: 10.18632/oncotarget.25548

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  103. Secondary cytoreductive surgery potentially improves the oncological outcomes of patients with recurrent uterine sarcomas.

    Nakamura K, Kajiyama H, Utsumi F, Suzuki S, Niimi K, Sekiya R, Sakata J, Yamamoto E, Shibata K, Kikkawa F

    Molecular and clinical oncology   Vol. 8 ( 3 ) page: 499 - 503   2018.3

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    DOI: 10.3892/mco.2018.1560

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  104. A post-recurrence survival-predicting indicator for cervical cancer from the analysis of 165 patients who developed recurrence.

    Yoshida K, Kajiyama H, Utsumi F, Niimi K, Sakata J, Suzuki S, Shibata K, Kikkawa F

    Molecular and clinical oncology   Vol. 8 ( 2 ) page: 281 - 285   2018.2

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    DOI: 10.3892/mco.2017.1530

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  105. The possible existence of occult metastasis in patients with ovarian clear-cell carcinoma who underwent complete resection without any residual tumours.

    Kajiyama H, Suzuki S, Yoshihara M, Nishino K, Yoshikawa N, Utsumi F, Niimi K, Mizuno M, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Nagasaka T, Shibata K, Kikkawa F

    Oncotarget   Vol. 9 ( 5 ) page: 6298 - 6307   2018.1

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    DOI: 10.18632/oncotarget.23921

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  106. A novel mechanism of neovascularization in peritoneal dissemination via cancer-associated mesothelial cells affected by TGF-β derived from ovarian cancer

    Fujikake, K; Kajiyama, H; Yoshihara, M; Nishino, K; Yoshikawa, N; Utsumi, F; Suzuki, S; Niimi, K; Sakata, J; Mitsui, H; Shibata, K; Senga, T; Kikawa, F

    ONCOLOGY REPORTS   Vol. 39 ( 1 ) page: 193 - 200   2018.1

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  107. Efficacy of medroxyprogesterone acetate treatment and retreatment for atypical endometrial hyperplasia and endometrial cancer

    Tamauchi, S; Kajiyama, H; Utsumi, F; Suzuki, S; Niimi, K; Sakata, J; Mizuno, M; Shibata, K; Kikkawa, F

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 44 ( 1 ) page: 151 - 156   2018.1

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  108. The role of N-acetylg lucosaminyltransferase IVa in choriocarcinoma progression

    Nishino, K; Yamamoto, E; Nakamura, K; Niimi, K; Kikkawa, F

    CANCER SCIENCE   Vol. 109   page: 254 - 254   2018.1

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  109. Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells

    Sakata, J; Utsumi, F; Suzuki, S; Niimi, K; Yamamoto, E; Shibata, K; Senga, T; Kikkawa, F; Kajiyama, H

    ONCOTARGET   Vol. 8 ( 59 ) page: 99482 - 99494   2017.11

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  110. Impact of positive ZEB1 expression in patients with epithelial ovarian carcinoma as an oncologic outcome-predicting indicator

    Sakata, J; Kajiyama, H; Suzuki, S; Utsumi, F; Niimi, K; Sekiya, R; Shibata, K; Senga, T; Kikkawa, F

    ONCOLOGY LETTERS   Vol. 14 ( 4 ) page: 4287 - 4293   2017.10

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  111. Establishment and characterization of cell lines derived from complete hydatidiform mole

    Yamamoto, E; Niimi, K; Kiyono, T; Yamamoto, T; Nishino, K; Nakamura, K; Kotani, T; Kajiyama, H; Shibata, K; Kikkawa, F

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   Vol. 40 ( 3 ) page: 614 - 622   2017.9

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  112. Spontaneous regression of gestational trophoblastic neoplasia.

    Niimi K, Yamamoto E, Nishino K, Fujiwara S, Ino K, Kikkawa F

    Gynecologic oncology reports   Vol. 21   page: 98 - 100   2017.8

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    DOI: 10.1016/j.gore.2017.07.011

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  113. Clinical significance and predicting indicators of post-cancer-treatment survival in terminally ill patients with ovarian cancer

    Utsumi, F; Kajiyama, H; Niimi, K; Sekiya, R; Sakata, J; Suzuki, S; Shibata, K; Mizuno, M; Kikkawa, F

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 43 ( 2 ) page: 365 - 370   2017.2

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  114. c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling

    Sekiya, Y; Yamamoto, E; Niimi, K; Nishino, K; Nakamura, K; Kotani, T; Kajiyama, H; Shibata, K; Kikkawa, F

    ONCOLOGY   Vol. 92 ( 5 ) page: 299 - 310   2017

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KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. Elucidating Malignant Transformation in Gestational Trophoblastic Disease Through Spatial Microenvironment Analysis for Therapeutic Applications

    Grant number:26K12304  2026.4 - 2029.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

  2. 多層的ゲノム解析を用いた絨毛性腫瘍の悪性化因子同定による新規治療開発

    Grant number:23K08864  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    新美 薫, 奥野 友介

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    絨毛性腫瘍は、半分が非自己で存在する「妊娠」が原因で発生する希少疾患である。一般的ながんの免疫環境やゲノムプロファイルとは異なるため、本腫瘍に特化した研究や治療が必要である。本研究では、絨毛性腫瘍と前がん状態ともいえる侵入奇胎、胞状奇胎における網羅的ゲノム解析を行い、悪性化に関与する因子を同定する。また、抗癌剤耐性絨毛癌や高hCG分泌例におけるトランスクリプトーム解析を行い、新規の免疫治療標的、悪性化機構を特定し、治療標的を見極める。さらに絨毛癌のPDXモデルを用いて新規治療薬の抗腫瘍効果を検証することで、臨床への応用を進める。
    ①次世代シーケンサーを用いた絨毛癌組織(妊娠性絨毛癌8例、非妊娠性絨毛癌6例)の全ゲノム解析を施行した。コピー数を確認したところ、抗がん剤使用後は使用前に比べてコピー数が増加していた。絨毛癌では遺伝子変異数の増加よりもコピー数変化が重要である可能性がある。コピー数変化を起こす遺伝子については解析中である。
    ②胞状奇胎のうち自然寛解例7例と侵入奇胎続発例6例の新鮮凍結組織から採取したRNAを用いてmRNAシーケンスを行った。自然寛解群と侵入奇胎続発群をパスウェイ解析し、比較したところ、XBP1という遺伝子が関与するpathwayが侵入奇胎で上昇していた。XBP1の機能解析を行った。XBP1の発現抑制で絨毛癌細胞の遊走、浸潤が抑制され、胞状奇胎細胞にXBP1を強制発現させたところ、遊走、浸潤が増強した。さらに胞状奇胎細胞株とXBP1を過剰発現させた細胞株をヌードマウスの子宮に移植したところ、XBP1過剰発現株移植群で腫瘍が生着し増大した。XBP1は胞状奇胎が侵入奇胎となる状況に大きく関与している可能性が示唆された。
    ③MTX耐性絨毛癌細胞株(Jar、JEG3)の作成を行った。MTX耐性に対する新規治療薬の探索を行った。作成したMTX耐性株に効果のある薬剤をDrug libraryを用いてスクリーニングした。臨床的に使用しやすい20個の薬剤をピックアップした。親株と耐性株それぞれで薬剤の効果を確認したところ、耐性株でも効果のある2個の薬剤に絞ることができた。
    胞状奇胎のうち自然寛解例と侵入奇胎続発例の新鮮凍結組織から採取したRNAを用いたRNAシーケンス解析により、XBP1という侵入奇胎発生に深く関与すると考えられる遺伝子を見いだせた。
    妊娠性絨毛癌のDNA抽出および全エクソーム解析について、まとめる。また、プロテオミクス解析、RNAシーケンス解析、miRNAシーケンス解析をあわせて行っていく予定。

  3. Establishment of a comprehensive cancer immunotherapy based on whole-genome analysis for treatment-resistant choriocarcinoma

    Grant number:20K09639  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Niimi Kaoru

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    We attempted to identify gene mutations by whole-genome analysis of choriocarcinoma tissues using next-generation sequencer. The number of gene mutations in gestational tumors was around 30, while the median number of gene mutations in non-gestational tumors was 150. TP53 gene mutations were observed in two cases of gestational tumors, suggesting the possibility of driver genes for choriocarcinoma. We analyzed the anti-tumor immune response by site of trophoblastic tumors, and found that the NK cell/CD8+ T cell ratio was higher in the tumor than in the peripheral blood, and that the ratio was higher in choriocarcinoma cases than in endometrial cancer cases at the tumor site. We successfully established an in vivo model (Patient-derived xenograft: PDX model) using tumor fatigue from a patient with non-gestational choriocarcinoma.

  4. analysis of immune factor in choriocarcinoma microenvironment

    Grant number:17K16845  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Niimi Kaoru

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    We investigated C2GnT expression in gestational trophoblastic diseases. We established C2GnT knockout (KO) cells with Jar and BeWo cells and investigated cytotoxicity of NK cells against those cells. MICA and MUC1 glycosylation were analyzed by immunoprecipitation. We incubated C2GnT-KO and control with TRAIL and cell viability were analyzed. We inoculated the C2GnT-KO and control cells subcutaneously into nude mice. C2GnT was highly expressed in trophoblasts of choriocarcinoma but not in hydatidiform mole and normal placenta. C2GnT-KO cells were more efficiently killed by NK cells than controls. Sugar chains attached by C2GnT on MICA and MUC1 in C2GnT-KO cells were significantly decreased. The cell viability of C2GnT-KO cells were lower than controls depending on TRAIL amount. C2GnT-KO promoted longer survival as compared with the controls. Choriocarcinoma cells may acquire a high malignant potential by expressing C2GnT with glycosylation to MICA and MUC1.

  5. Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam

    Grant number:15H02660  2015.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    FUMITAKA KIKKAWA

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    Authorship:Coinvestigator(s) 

    For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.

  6. 糖転移酵素C2GnTによる絨毛細胞の浸潤機序の解明と治療への応用

    2014.4

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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