研究者詳細 - 小峯　起

論文 - 小峯　起

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Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders 査読有り Open Access

Fuma, K; Iitani, Y; Imai, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Miki, R; Kidokoro, H; Sato, Y; Hara, Y; Ogi, T; Nomaki, K; Tsuda, M; Komine, O; Yamanaka, K; Kajiyama, H; Kotani, T

COMMUNICATIONS BIOLOGY 8 巻 ( 1 ) 頁： 75 2025年1月

ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice 査読有り

Horiuchi, M; Watanabe, S; Komine, O; Takahashi, E; Kaneko, K; Itohara, S; Shimada, M; Ogi, T; Yamanaka, K

ACTA NEUROPATHOLOGICA COMMUNICATIONS 12 巻 ( 1 ) 頁： 184 2024年11月

Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation 査読有り

Sobue, A; Komine, O; Endo, F; Kakimi, C; Miyoshi, Y; Kawade, N; Watanabe, S; Saito, Y; Murayama, S; Saido, TC; Saito, T; Yamanaka, K

CELL DEATH & DISEASE 15 巻 ( 11 ) 頁： 858 2024年11月

Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia 査読有り

Fujisawa, H; Watanabe, T; Komine, O; Fuse, S; Masaki, M; Iwata, N; Murao, N; Seino, Y; Takeuchi, H; Yamanaka, K; Sawada, M; Suzuki, A; Sugimura, Y

FREE RADICAL BIOLOGY AND MEDICINE 223 巻頁： 458 - 472 2024年10月

Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease 査読有り

Wang, T; Sobue, A; Watanabe, S; Komine, O; Saido, TC; Saito, T; Yamanaka, K

JOURNAL OF NEUROINFLAMMATION 21 巻 ( 1 ) 頁： 55 2024年2月

Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice 査読有り Open Access

Komine, O; Ohnuma, S; Hinohara, K; Hara, Y; Shimada, M; Akashi, T; Watanabe, S; Sobue, A; Kawade, N; Ogi, T; Yamanaka, K

ISCIENCE 27 巻 ( 2 ) 頁： 108872 2024年2月

Mitochondria- associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS 査読有り

Watanabe, S; Murata, Y; Oka, Y; Oiwa, K; Horiuchi, M; Iguchi, Y; Komine, O; Sobue, A; Katsuno, M; Ogi, T; Yamanaka, K

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 巻 ( 47 ) 頁： e2315347120 2023年11月

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis 査読有り

Oiwa, K; Watanabe, S; Onodera, K; Iguchi, Y; Kinoshita, Y; Komine, O; Sobue, A; Okada, Y; Katsuno, M; Yamanaka, K

SCIENCE ADVANCES 9 巻 ( 31 ) 頁： eadf6895 2023年8月

Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype 査読有り

Matsudaira, T; Nakano, S; Konishi, Y; Kawamoto, S; Uemura, K; Kondo, T; Sakurai, K; Ozawa, T; Hikida, T; Komine, O; Yamanaka, K; Fujita, Y; Yamashita, T; Matsumoto, T; Hara, E

COMMUNICATIONS BIOLOGY 6 巻 ( 1 ) 頁： 665 2023年6月

Neuroinflammation in Alzheimer's disease: microglial signature and their relevance to disease 査読有り

Sobue, A; Komine, O; Yamanaka, K

INFLAMMATION AND REGENERATION 43 巻 ( 1 ) 頁： 26 2023年5月

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis 査読有り

Watanabe, S; Horiuchi, M; Murata, Y; Komine, O; Kawade, N; Sobue, A; Yamanaka, K

NEUROBIOLOGY OF DISEASE 179 巻頁： 106031 2023年4月

Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease (Volume-17, page-1, year-2023) 査読有り

Yamashita, H; Komine, O; Fujimori-Tonou, N; Yamanaka, K

FRONTIERS IN CELLULAR NEUROSCIENCE 17 巻頁： 1160444 2023年3月

Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease 査読有り

Yamashita, H; Komine, O; Fujimori-Tonou, N; Yamanaka, K

FRONTIERS IN CELLULAR NEUROSCIENCE 16 巻頁： 1045647 2023年1月

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis 査読有り

Sakai, S; Watanabe, S; Komine, O; Sobue, A; Yamanaka, K

FASEB JOURNAL 35 巻 ( 7 ) 頁： e21688 2021年7月

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease 査読有り

Sobue, A; Komine, O; Hara, Y; Endo, F; Mizoguchi, H; Watanabe, S; Murayama, S; Saito, T; Saido, TC; Sahara, N; Higuchi, M; Ogi, T; Yamanaka, K

ACTA NEUROPATHOLOGICA COMMUNICATIONS 9 巻 ( 1 ) 頁： 1 2021年1月

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction 査読有り

Konishi, H; Okamoto, T; Hara, Y; Komine, O; Tamada, H; Maeda, M; Osako, F; Kobayashi, M; Nishiyama, A; Kataoka, Y; Takai, T; Udagawa, N; Jung, SF; Ozato, K; Tamura, T; Tsuda, M; Yamanaka, K; Ogi, T; Sato, K; Kiyama, H

EMBO JOURNAL 39 巻 ( 22 ) 頁： e104464 2020年11月

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an <i>App</i> knock-in mouse model of Alzheimer's disease 査読有り

Saifullah, MAB; Komine, O; Dong, YT; Fukumoto, K; Sobue, A; Endo, F; Saito, T; Saido, TC; Yamanaka, K; Mizoguchi, H

MOLECULAR BRAIN 13 巻 ( 1 ) 頁： 147 2020年11月

Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43 査読有り

Watanabe, S; Inami, H; Oiwa, K; Murata, Y; Sakai, S; Komine, O; Sobue, A; Iguchi, Y; Katsuno, M; Yamanaka, K

CELL DEATH & DISEASE 11 巻 ( 10 ) 頁： 909 2020年10月

Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions 査読有り

Sugiyama, M; Banno, R; Yaginuma, H; Taki, K; Mizoguchi, A; Tsunekawa, T; Onoue, T; Takagi, H; Ito, Y; Iwama, S; Goto, M; Suga, H; Komine, O; Yamanaka, K; Arima, H

NEUROCHEMISTRY INTERNATIONAL 136 巻頁： 104733 2020年6月

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair 査読有り

Nakazawa, Y; Hara, Y; Oka, Y; Komine, O; van den Heuvel, D; Guo, CW; Daigaku, Y; Isono, M; He, YX; Shimada, M; Kato, K; Jia, N; Hashimoto, S; Kotani, Y; Miyoshi, Y; Tanaka, M; Sobue, A; Mitsutake, N; Suganami, T; Masuda, A; Ohno, K; Nakada, S; Mashimo, T; Yamanaka, K; Luijsterburg, MS; Ogi, T

CELL 180 巻 ( 6 ) 頁： 1228 - + 2020年3月

ALS-linked TDP-43<SUP>M337V</SUP> knock-in mice exhibit splicing deregulation without neurodegeneration 査読有り

Watanabe, S; Oiwa, K; Murata, Y; Komine, O; Sobue, A; Endo, F; Takahashi, E; Yamanaka, K

MOLECULAR BRAIN 13 巻 ( 1 ) 頁： 8 2020年1月

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway 査読有り

Nishino, K; Watanabe, S; Shijie, J; Murata, Y; Oiwa, K; Komine, O; Endo, F; Tsuiji, H; Abe, M; Sakimura, K; Mishra, A; Yamanaka, K

ACTA NEUROPATHOLOGICA COMMUNICATIONS 7 巻 ( 1 ) 頁： 118 2019年7月

The multi-dimensional roles of astrocytes in ALS 査読有り

Yamanaka, K; Komine, O

NEUROSCIENCE RESEARCH 126 巻頁： 31 - 38 2018年1月

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes 査読有り

Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K

Cell Death and Differentiation 2018年

Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice 査読有り

Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K

Journal of Neurochemistry 2017年12月

Mice heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction 査読有り

Nishino, K; Watanabe, S; Komine, O; Endo, F; Yamanaka, K

JOURNAL OF THE NEUROLOGICAL SCIENCES 381 巻頁： 570 - 570 2017年10月

Collapse of mitochondria-associated membrane as common pathomechanism for amyotrophic lateral sclerosis

Watanabe, S; Ilieva, H; Tamada, H; Nomura, H; Komine, O; Endo, F; Jin, S; Mancias, P; Kiyama, H; Yamanaka, K

JOURNAL OF THE NEUROLOGICAL SCIENCES 381 巻頁： 104 - 104 2017年10月

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS. 査読有り

Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, *Yamanaka K.

EMBO Mol Med 8 巻頁： 1421-1437 2016年11月

Neuroinflammation in motor neuron disease. 査読有り

Endo F, Komine O, Yamanaka K.

Clinical and Experimental Neuroimmunology 7 巻頁： 126-138 2016年5月

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. 査読有り

Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, *Yamanaka K

Acta Neuropathologica Communications 4 巻 ( 15 ) 2016年2月

Neuroinflammation in motor neuron disease 査読有り

Nagoya Journal of Medical Science 77 巻 ( 4 ) 頁： 537 - 549 2015年11月

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells 査読有り

Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K

Cell Reports 11 巻 ( 4 ) 頁： 592-604 2015年4月

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. 査読有り

Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyazawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K

Molecular Brain 7 巻頁： 62 2014年8月

Delta-like 1 regulates bergmann glial monolayer formation during cerebellar development. 査読有り

Hiraoka Y, Komine O, Nagaoka M, Bai N, Hozumi K, Tanaka K

Molecular Brain 6 巻頁： 25-36 2013年5月

RBP-J promotes the maturation of neuronal progenitors. 査読有り

Komine O, Nagaoka M, Hiraoka Y, Hoshino M, Kawaguchi Y, S. Pear W, Tanaka K

Development Biology 354 巻 ( 1 ) 頁： 44-54 2011年6月

The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. 査読有り

Komine O, Nagaoka M, Watase K, H. Gutmann D, Tanigaki K, Honjo T, Radtke F, Saito T, Chiba S, Tanaka K

Developmental Biology 311 巻 ( 1 ) 頁： 238-250 2007年11月

Imprinting modulates processing of visual information in the visual wulst of chicks. 査読有り

Maekawa F, Komine O, Sato K, Kanamatsu T, Uchimura M, Tanaka K, Ohki-Hamazaki H.

BMC Neuroscience 7 巻頁： 75-87 2006年11月

Differential roles of glial and and neuronal glutamate transporters in Purkinje cells synapses. 査読有り

Takayasu Y, Iino M, Kakegawa W, Maeno H, Watase K, Wada K, Yanagihara D, Miyazaki T, Komine O, Watanabe M, Tanaka K, Ozawa S.

The Journal of Neuroscience 25 巻 ( 38 ) 頁： 8788-8793 2005年9月

The Runx1 transcription factor inhibits the differentiation of naive CD4+T cells into the Th2 lineage by repressing GATA3 expression. 査読有り

Komine O, Hayashi K, Natsume W, Watanabe T, Seki Y, Seki N, Yagi R, Suzuki W, Tamauchi H, Hozumi K, Habu S, Kubo M, Satake M.

The Journal of Experimental Medicine 198 巻 ( 1 ) 頁： 51-61 2003年7月

SOCS-3 regulates onset and maintenance of Th2-mediated allergic responses. 査読有り

Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano K, O'Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A, Kubo M.

Nature Medicine 9 巻 ( 8 ) 頁： 1047-1054 2003年6月

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