研究者詳細 - 石川　由希

論文 - 石川　由希

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特集関わり合う脳 Ⅳ.社会性を進化する脳求愛歌の好みの進化を支える神経機構

石川由希, 大橋拓朗, 上川内あづさ

生体の科学 76 巻 ( 1 ) 頁： 72 - 77 2025年2月

Neural-circuit basis of song preference learning in fruit flies

Imoto, K; Ishikawa, Y; Aso, Y; Funke, J; Tanaka, R; Kamikouchi, A

ISCIENCE 27 巻 ( 7 ) 頁： 110266 - 110266 2024年6月

Evolutionary conservation and diversification of auditory neural circuits that process courtship songs in Drosophila 査読有り国際誌 Open Access

Takuro S. Ohashi, Yuki Ishikawa, Takeshi Awasaki, Matthew P. Su, Yusuke Yoneyama, Nao Morimoto, Azusa Kamikouchi

Scientific Reports 13 巻 ( 1 ) 頁： 383 - 383 2023年1月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Acoustic communication signals diversify even on short evolutionary time scales. To understand how the auditory system underlying acoustic communication could evolve, we conducted a systematic comparison of the early stages of the auditory neural circuit involved in song information processing between closely-related fruit-fly species. Male Drosophila melanogaster and D. simulans produce different sound signals during mating rituals, known as courtship songs. Female flies from these species selectively increase their receptivity when they hear songs with conspecific temporal patterns. Here, we firstly confirmed interspecific differences in temporal pattern preferences; D. simulans preferred pulse songs with longer intervals than D. melanogaster. Primary and secondary song-relay neurons, JO neurons and AMMC-B1 neurons, shared similar morphology and neurotransmitters between species. The temporal pattern preferences of AMMC-B1 neurons were also relatively similar between species, with slight but significant differences in their band-pass properties. Although the shift direction of the response property matched that of the behavior, these differences are not large enough to explain behavioral differences in song preferences. This study enhances our understanding of the conservation and diversification of the architecture of the early-stage neural circuit which processes acoustic communication signals.

DOI： 10.1038/s41598-022-27349-7

その他リンク： https://www.nature.com/articles/s41598-022-27349-7

Distinct decision-making properties underlying the species specificity of group formation of flies 査読有り Open Access

Riku Shirasaki, Ryoya Tanaka, Hiroki Takekata, Takashi Shimada, Yuki Ishikawa, Azusa Kamikouchi

Royal Society Open Science 9 巻 ( 8 ) 頁： 220042 2022年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Royal Society Open Science

Many animal species form groups. Group characteristics differ between species, suggesting that the decision-making of individuals for grouping varies across species. However, the actual decision-making properties that lead to interspecific differences in group characteristics remain unclear. Here, we compared the group formation processes of two Drosophilinae fly species, Colocasiomyia alocasiae and Drosophila melanogaster, which form dense and sparse groups, respectively. A high-throughput tracking system revealed that C. alocasiae flies formed groups faster than D. melanogaster flies, and the probability of C. alocasiae remaining in groups was far higher than that of D. melanogaster. C. alocasiae flies joined groups even when the group size was small, whereas D. melanogaster flies joined groups only when the group size was sufficiently large. C. alocasiae flies attenuated their walking speed when the inter-individual distance between flies became small, whereas such behavioural properties were not clearly observed in D. melanogaster. Furthermore, depriving C. alocasiae flies of visual input affected grouping behaviours, resulting in a severe reduction in group formation. These findings show that C. alocasiae decision-making regarding grouping, which greatly depends on vision, is significantly different from D. melanogaster, leading to species-specific group formation properties.

DOI： 10.1098/rsos.220042

その他リンク： https://royalsocietypublishing.org/doi/full-xml/10.1098/rsos.220042

Mate discrimination of Colocasiomyia xenalocasiae and C. alocasiae (Diptera: Drosophilidae) as a possible factor contributing to their co-existence on the same host plant. 査読有り

Ryoya Tanaka, Hiroki Takekata, Yuki Ishikawa, Azusa Kamikouchi

Journal of Insect Behavior 35 巻 ( 1-3 ) 頁： 44 - 55 2022年6月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Insect Behavior

Mate discrimination contributes to the co-existence of related species by reducing the risk of interspecific copulation. In pollination mutualistic systems where pollinators utilize host plants as mating places, sharing of host plants with other related species could increase non-adaptive interspecific copulation. Although such host-sharing species are expected to have strong mate discrimination systems, little is known about whether and how they discriminate species for mating. Here, we investigate mate discrimination of two fly species, Colocasiomyia xenalocasiae and C. alocasiae (Diptera: Drosophilidae), which share host plants; they are essentially anthophilous, depending exclusively on specific aroid host plants throughout their entire life cycles. Our field observations showed that the males of C. alocasiae and C. xenalocasiae preferentially paired with conspecific, but not heterospecific, females. This indicates that they discriminate species for mating in the natural habitat. Such mate discrimination was also observed under laboratory conditions. To investigate how these flies discriminate species, we defined distinct behavioral elements in courtship sequence in both species, and compared sexual interactions in each element between conspecific and heterospecific pairs. We found that males discriminate female whilst tapping, whereas females discriminate male before or during males’ attempted mounting. This suggests that mate discrimination systems in both males and females reduce the incidence of heterospecific mounting; mounting is a necessary step in the sequence of courtship for successful copulation. The mate discrimination system found in this study potentially allows for the co-existence of C. xenalocasiae and C. alocasiae on the same host plant by effectively suppressing interspecific copulation.

DOI： 10.1007/s10905-022-09798-0

Web of Science

Scopus

Biology and ecology of the Oriental flower-breeding Drosophila elegans and related species 招待有り査読有り Open Access

Yuki Ishikawa, Masahito T. Kimura, Masanori J. Toda

Fly 16 巻 ( 1 ) 頁： 207 - 220 2022年5月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Fly

Animals adapt to their environments in the course of evolution. One effective approach to elucidate mechanisms of adaptive evolution is to compare closely related species with model organisms in which knowledge of the molecular and physiological bases of various traits has been accumulated. Drosophila elegans and its close relatives, belonging to the same species group as the model organism D. melanogaster, exhibit various unique characteristics such as flower-breeding habit, courtship display, territoriality, sexual dimorphism, and colour polymorphism. Their ease of culturing and availability of genomic information makes them a useful model for understanding mechanisms of adaptive evolution. Here, we review the morphology, distribution, and phylogenetic relationships of D. elegans and related species, as well as their characteristic flower-dependent biology, food habits, and life-history traits. We also describe their unique mating and territorial behaviours and note their distinctive karyotype and the genetic mechanisms of morphological diversity that have recently been revealed.

DOI： 10.1080/19336934.2022.2066953

Wiring patterns from auditory sensory neurons to the escape and song-relay pathways in fruit flies 査読有り国際誌

Kim, H; Horigome, M; Ishikawa, Y; Li, F; Lauritzen, JS; Card, G; Bock, DD; Kamikouchi, A

JOURNAL OF COMPARATIVE NEUROLOGY 528 巻 ( 12 ) 頁： 2068 - 2098 2020年8月

Auditory experience prevents loss of the innate song preference as a selective cue in Drosophila

Xiaodong Li, James Kruszelnicki, Yukina Chiba, Hiroshi Ishimoto, Yuki Ishikawa, Azusa Kamikouchi

bioRxiv 2020年7月

出版者・発行元：Cold Spring Harbor Laboratory

<title>Abstract</title>Auditory learning is a prerequisite step for acoustic communication learning, which was previously assumed to be restricted to animals with high levels of cognition, such as humans, cetaceans, and birds. How animals that rely on auditory learning for acoustic communication form sound preferences is not known. Fruit flies are a recently proposed novel animal model for studying experience-dependent auditory perceptual plasticity because of their ability to acquire song preferences via song exposure. Whether fruit flies have innate courtship song preferences, however, is unclear. Here we report that, similar to songbirds, fruit flies exhibit an innate preference for conspecific courtship songs. Maintenance of innate song preference requires song input, reminiscent of the song learning process in songbirds. Our findings also indicate that the response to conspecific and heterospecific songs manifests temporal and experience-dependent differentiation, which may underlie innate song preference and its plasticity. In addition, we find that flies have a robust ability to reacquire song preference during aging. Fruit flies thus offer a novel and simple approach for studying sound preference formation and its underlying mechanisms.

DOI： 10.1101/2020.07.16.205443

Behavioral Evolution of Drosophila: Unraveling the Circuit Basis Open Access

Sato, K; Tanaka, R; Ishikawa, Y; Yamamoto, D

GENES 11 巻 ( 2 ) 2020年2月

記述言語：英語出版者・発行元：Genes

Behavior is a readout of neural function. Therefore, any difference in behavior among different species is, in theory, an outcome of interspecies diversification in the structure and/or function of the nervous system. However, the neural diversity underlying the species-specificity in behavioral traits and its genetic basis have been poorly understood. In this article, we discuss potential neural substrates for species differences in the courtship pulse song frequency and mating partner choice in the Drosophila melanogaster subgroup. We also discuss possible neurogenetic mechanisms whereby a novel behavioral repertoire emerges based on the study of nuptial gift transfer, a trait unique to D. subobscura in the genus Drosophila. We found that the conserved central circuit composed primarily of fruitless-expressing neurons (the fru-circuit) serves for the execution of courtship behavior, whereas the sensory pathways impinging onto the fru-circuit or the motor pathways downstream of the fru-circuit are susceptible to changes associated with behavioral species differences.

DOI： 10.3390/genes11020157

Stereotyped Combination of Hearing and Wind/Gravity-sensing Neurons in the Johnston’s Organ of Drosophila 査読有り国際誌

Ishikawa Yuki, Fujiwara Mao, Wong Junlin, Ura Akari, Kamikouchi Azusa

Frontiers in Physiology 10 巻頁： 1552 - 1552 2020年1月

A single male auditory response test to quantify auditory behavioral responses in Drosophila melanogaster 査読有り

Ishikawa, Y; Okamoto, N; Yoneyama, Y; Maeda, N; Kamikouchi, A

JOURNAL OF NEUROGENETICS 33 巻 ( 2 ) 頁： 64 - 74 2019年4月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neurogenetics

Many animals utilize auditory signals to communicate with conspecific individuals. During courtship, males of the fruit fly Drosophila melanogaster and related species produce a courtship song comprised of sine and pulse songs by vibrating their wings. The pulse song increases female receptivity and male courtship activity, indicating that it functions as a sexual signal. One song parameter, interpulse interval (IPI), varies among closely related species. In D. melanogaster, a song with a conspecific IPI induces a stronger behavioral response than heterospecific songs, indicating the ability of the flies to discriminate conspecific IPI. Traditionally, the fly’s response to the song is measured under grouped conditions, in which the effect of sensory modalities other than audition cannot be excluded. Here, to quantify the individual ability to discriminate a conspecific song, we systematically analyzed the auditory response of single male flies to sound with various parameters. Moreover, we applied this method, termed SMART (Single Male Auditory Response Test), to two sister species for potential application in a comparative approach. By quantifying the locomotor activity of single D. melanogaster males during sound exposure, we detected increased locomotor activity in response to pulse songs, but not to white noise or pure tone. The conspecific song evoked stronger response than the heterospecific songs, and ablation of their antennal receivers severely suppressed the locomotor increase. A pulse song with a small IPI variation evoked a continuous response, while the response to songs with highly variable IPIs tends to be rapidly decayed. This provides the first evidence that fruit flies discriminate IPI variations, which possibly inform the age and social contexts of the singer. Sister species, D. sechellia, exhibited a locomotor response to pulse song, while D. simulans exhibited no behavioral response. This suggests that auditory and other stimuli that elicit this behavioral response are diversified among Drosophila species.

DOI： 10.1080/01677063.2019.1611805

Web of Science

Scopus

PubMed

STEFTR: A Hybrid Versatile Method for State Estimation and Feature Extraction From the Trajectory of Animal Behavior 査読有り国際誌

Yamazaki Shuhei J., Ohara Kazuya, Ito Kentaro, Kokubun Nobuo, Kitanishi Takuma, Takaichi Daisuke, Yamada Yasufumi, Ikejiri Yosuk, Hiramatsu Fumie, Fujita Kosuke, Tanimoto Yuki, Yamazoe-Umemoto Akiko, Hashimoto Koichi, Sato Katsufumi, Yoda Ken, Takahashi Akinori, Ishikawa Yuki, Kamikouchi Azusa, Hiryu Shizuko, Maekawa Takuya, Kimura Koutarou D.

FRONTIERS IN NEUROSCIENCE 13 巻頁： 626 - 626 2019年

GABAergic Local Interneurons Shape Female Fruit Fly Response to Mating Songs 査読有り

Yamada, D; Ishimoto, H; Li, XD; Kohashi, T; Ishikawa, Y; Kamikouchi, A

JOURNAL OF NEUROSCIENCE 38 巻 ( 18 ) 頁： 4329 - 4347 2018年5月

Anatomic and Physiologic Heterogeneity of Subgroup-A Auditory Sensory Neurons in Fruit Flies 査読有り

Yuki Ishikawa, Natsuki Okamoto, Mizuki Nakamura, Hyunsoo Kim, Azusa Kamikouchi

Frontiers in Neural Circuits 2017年6月

The function of appendage patterning genes in mandible development of the sexually dimorphic stag beetle 査読有り

Gotoh, H; Zinna, RA; Ishikawa, Y; Miyakawa, H; Ishikawa, A; Sugime, Y; Emlen, DJ; Lavine, LC; Miura, T

DEVELOPMENTAL BIOLOGY 422 巻 ( 1 ) 頁： 24 - 32 2017年2月

Neuronal mechanisms of evolution of species-specific pheromone preference in Drosophila

Ishikawa Yuki, Kamikouchi Azusa, Yamamoto Daisuke

GENES & GENETIC SYSTEMS 91 巻 ( 6 ) 頁： 325 - 325 2016年12月

Auditory system of fruit flies 査読有り

Ishikawa, Y; Kamikouchi, A

HEARING RESEARCH 338 巻頁： 1 - 8 2016年8月

Tyraminergic and Octopaminergic Modulation of Defensive Behavior in Termite Soldier 査読有り国際誌 Open Access

Ishikawa, Y; Aonuma, H; Sasaki, K; Miura, T

PLOS ONE 11 巻 ( 5 ) 頁： e0154230 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

In termites, i.e. a major group of eusocial insects, the soldier caste exhibits specific morphological characteristics and extremely high aggression against predators. Although the genomic background is identical to the other non-aggressive castes, they acquire the soldier-specific behavioral character during the course of caste differentiation. The high aggressiveness and defensive behavior is essential for colony survival, but the neurophysiological bases are completely unknown. In the present study, using the damp-wood termite Hodotermopsis sjostedti, we focused on two biogenic amines, octopamine (OA) and tyramine (TA), as candidate neuromodulators for the defensive behavior in soldiers. High-performance liquid chromatographic analysis revealed that TA levels in the brain and suboesophageal ganglion (SOG) and the OA level in brain were increased in soldiers than in pseudergates (worker caste). Immunohistochemical analysis revealed that TA/OA neurons that innervate specific areas, including the mandibular muscles, antennal nerve, central complex, suboesophageal ganglion, and thoracic and/or abdominal ganglia, were enlarged in a soldier-specific manner. Together with the results that pharmacological application of TA promoted the defensive behavior in pseudergates, these findings suggest that the increased TA/OA levels induce the higher aggressiveness and defensive behavior in termite soldiers. The projection targets of these soldier-specific enlarged TA/OA neurons may have important roles in the higher aggressiveness and defensive behavior of the termite soldiers, inducing the neuronal transition that accompanies external morphological changes.

DOI： 10.1371/journal.pone.0154230

シロアリの社会性とそれを支える生理／神経機構

石川由希

比較生理生化学 33 巻 ( 4 ) 頁： 191 - 202 2016年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本比較生理生化学会

シロアリは，高度に発達した社会構造を持つ昆虫である。この社会性は，ほぼ同一のゲノムから生まれた個体が異なるふるまい（＝分業）をおこなうことによって成立している。どのような仕組みで同一ゲノムから生まれた個体が異なる行動や形態を示すようになるのだろうか？また単独性の祖先種から，どのように複雑な社会性が進化したのだろうか？本稿ではまず，シロアリの社会性に関して，特に混乱しがちな特殊な用語を含めながら解説する。次に，同一のゲノムから異なる表現型が分化する発生経路やその仕組みに関して紹介する。さらに，それぞれの個体が異なるタスクを分担する神経生理学的基盤に関する最新の研究を紹介する。最後に，シロアリの社会性進化がどのような生理／神経機構の改変に起こってきたのかを考察する。

DOI： 10.3330/hikakuseiriseika.33.191

CiNii Books

CiNii Research

Hearing in Drosophila

Kamikouchi, A; Ishikawa, Y

INSECT HEARING: WITH 53 ILLUSTRATIONS 55 巻頁： 239 - 262 2016年

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