Updated on 2025/03/26

写真a

 
ISHIKAWA Yuki
 
Organization
Graduate School of Science Lecturer
Graduate School
Graduate School of Science
Undergraduate School
School of Science Department of Biological Science
Title
Lecturer

Degree 1

  1. PhD ( 2011.3   Hokkaido University ) 

Research Interests 8

  1. flower visiting

  2. Drosophila simulans

  3. Drosophila melanogaster

  4. Drosophila elegans

  5. mating preference

  6. behavioral evolution

  7. courtship behavior

  8. fruit fly

Research Areas 8

  1. Life Science / Evolutionary biology

  2. Life Science / Neuroscience-general

  3. Life Science / Ecology and environment

  4. Life Science / Animal physiological chemistry, physiology and behavioral biology

  5. Life Science / Neuroscience-general

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Research History 2

  1. Nagoya University   Graduate School of Science   Lecturer

    2017.11

  2. Nagoya University   Graduate School of Science   Designated assistant professor

    2013.8 - 2017.10

Education 3

  1. Hokkaido University   Graduate School of Environmental Science

    2008.4 - 2011.3

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    Country: Japan

  2. Hokkaido University   Graduate School of Environmental Science

    2006.4 - 2008.3

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    Country: Japan

  3. Hokkaido University   School of Science   Biological Sciences

    2002.4 - 2006.3

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    Country: Japan

Professional Memberships 5

  1. SOCIETY OF EVOLUTIONARY STUDIES, JAPAN

  2. THE JAPAN NEUROSCIENCE SOCIETY

  3. ECOLOGICAL SOCIETY OF JAPAN

  4. THE JAPANESE SOCIETY FOR COMPARATIVE PHYSIOLOGY AND BIOCHEMISTRY

  5. THE ZOOLOGICAL SOCIETY OF JAPAN

Committee Memberships 23

  1. 日本進化学会   代議員  

    2024.7 - 2026.6   

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    Committee type:Academic society

  2. 日本比較生理生化学会   将来計画委員  

    2024.4 - 2026.3   

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    Committee type:Academic society

  3. 日本動物学会   男女共同参画委員  

    2023.11   

  4. 日本動物学会   男女共同参画委員会  

    2023.11   

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    Committee type:Academic society

  5. 日本比較生理生化学会   評議委員  

    2022.4   

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Awards 5

  1. Poster Award for Excellence, The 46th Naito Conference

    2018.10   The Naito Foundation  

    Yuki Ishikawa

  2. 第27回高遠分子細胞生物学シンポジウム優秀ポスター賞

    2015.8   高遠分子細胞生物学シンポジウム  

    石川 由希

  3. Yoshida Young Research Award

    2014.7   The Japanese Society of Comparative Physiology and Biochemistry  

    Yuki Ishikawa

  4. Heart Prize 2007

    2007.11   Heart Co. Ltd.  

    Yuki Ishikawa

  5. Award for best poster prize

    2006.3   The Ecological Society of Japan  

    Yuki Ishikawa

 

Papers 34

  1. 特集 関わり合う脳 Ⅳ.社会性を進化する脳 求愛歌の好みの進化を支える神経機構

    石川 由希, 大橋 拓朗, 上川内 あづさ

    生体の科学   Vol. 76 ( 1 ) page: 72 - 77   2025.2

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    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.037095310760010072

    CiNii Research

  2. Neural-circuit basis of song preference learning in fruit flies

    Keisuke Imoto, Yuki Ishikawa, Yoshinori Aso, Jan Funke, Ryoya Tanaka, Azusa Kamikouchi

    iScience   Vol. 27 ( 7 ) page: 110266 - 110266   2024.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.isci.2024.110266

    Web of Science

    PubMed

  3. Evolutionary conservation and diversification of auditory neural circuits that process courtship songs in Drosophila Reviewed International journal Open Access

    Takuro S. Ohashi, Yuki Ishikawa, Takeshi Awasaki, Matthew P. Su, Yusuke Yoneyama, Nao Morimoto, Azusa Kamikouchi

    Scientific Reports   Vol. 13 ( 1 ) page: 383 - 383   2023.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Acoustic communication signals diversify even on short evolutionary time scales. To understand how the auditory system underlying acoustic communication could evolve, we conducted a systematic comparison of the early stages of the auditory neural circuit involved in song information processing between closely-related fruit-fly species. Male Drosophila melanogaster and D. simulans produce different sound signals during mating rituals, known as courtship songs. Female flies from these species selectively increase their receptivity when they hear songs with conspecific temporal patterns. Here, we firstly confirmed interspecific differences in temporal pattern preferences; D. simulans preferred pulse songs with longer intervals than D. melanogaster. Primary and secondary song-relay neurons, JO neurons and AMMC-B1 neurons, shared similar morphology and neurotransmitters between species. The temporal pattern preferences of AMMC-B1 neurons were also relatively similar between species, with slight but significant differences in their band-pass properties. Although the shift direction of the response property matched that of the behavior, these differences are not large enough to explain behavioral differences in song preferences. This study enhances our understanding of the conservation and diversification of the architecture of the early-stage neural circuit which processes acoustic communication signals.

    DOI: 10.1038/s41598-022-27349-7

    Open Access

    Web of Science

    Scopus

    PubMed

    Other Link: https://www.nature.com/articles/s41598-022-27349-7

  4. Distinct decision-making properties underlying the species specificity of group formation of flies Reviewed Open Access

    Riku Shirasaki, Ryoya Tanaka, Hiroki Takekata, Takashi Shimada, Yuki Ishikawa, Azusa Kamikouchi

    Royal Society Open Science   Vol. 9 ( 8 ) page: 220042   2022.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Royal Society  

    Many animal species form groups. Group characteristics differ between species, suggesting that the decision-making of individuals for grouping varies across species. However, the actual decision-making properties that lead to interspecific differences in group characteristics remain unclear. Here, we compared the group formation processes of two Drosophilinae fly species, Colocasiomyia alocasiae and Drosophila melanogaster , which form dense and sparse groups, respectively. A high-throughput tracking system revealed that C. alocasiae flies formed groups faster than D. melanogaster flies, and the probability of C. alocasiae remaining in groups was far higher than that of D. melanogaster . C. alocasiae flies joined groups even when the group size was small, whereas D. melanogaster flies joined groups only when the group size was sufficiently large. C. alocasiae flies attenuated their walking speed when the inter-individual distance between flies became small, whereas such behavioural properties were not clearly observed in D. melanogaster . Furthermore, depriving C. alocasiae flies of visual input affected grouping behaviours, resulting in a severe reduction in group formation. These findings show that C. alocasiae decision-making regarding grouping, which greatly depends on vision, is significantly different from D. melanogaster , leading to species-specific group formation properties.

    DOI: 10.1098/rsos.220042

    Open Access

    Web of Science

    Scopus

    PubMed

    Other Link: https://royalsocietypublishing.org/doi/full-xml/10.1098/rsos.220042

  5. Mate discrimination of Colocasiomyia xenalocasiae and C. alocasiae (Diptera: Drosophilidae) as a possible factor contributing to their co-existence on the same host plant. Reviewed

    Ryoya Tanaka, Hiroki Takekata, Yuki Ishikawa, Azusa Kamikouchi

    Journal of Insect Behavior   Vol. 35 ( 1-3 ) page: 44 - 55   2022.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Mate discrimination contributes to the co-existence of related species by reducing the risk of interspecific copulation. In pollination mutualistic systems where pollinators utilize host plants as mating places, sharing of host plants with other related species could increase non-adaptive interspecific copulation. Although such host-sharing species are expected to have strong mate discrimination systems, little is known about whether and how they discriminate species for mating. Here, we investigate mate discrimination of two fly species, Colocasiomyia xenalocasiae and C. alocasiae (Diptera: Drosophilidae), which share host plants; they are essentially anthophilous, depending exclusively on specific aroid host plants throughout their entire life cycles. Our field observations showed that the males of C. alocasiae and C. xenalocasiae preferentially paired with conspecific, but not heterospecific, females. This indicates that they discriminate species for mating in the natural habitat. Such mate discrimination was also observed under laboratory conditions. To investigate how these flies discriminate species, we defined distinct behavioral elements in courtship sequence in both species, and compared sexual interactions in each element between conspecific and heterospecific pairs. We found that males discriminate female whilst tapping, whereas females discriminate male before or during males’ attempted mounting. This suggests that mate discrimination systems in both males and females reduce the incidence of heterospecific mounting; mounting is a necessary step in the sequence of courtship for successful copulation. The mate discrimination system found in this study potentially allows for the co-existence of C. xenalocasiae and C. alocasiae on the same host plant by effectively suppressing interspecific copulation.

    DOI: 10.1007/s10905-022-09798-0

    Web of Science

    Scopus

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Books 6

  1. 生き物と音の事典

    石川 由希, 上川内 あづさ( Role: Contributor ,  ショウジョウバエの音コミュニケーション)

    朝倉書店  2019.11  ( ISBN:9784254171679

  2. 遺伝子から解き明かす脳の不思議な世界

    上川内 あづさ, 石川 由希( Role: Contributor ,  第4章 小型でハイスペックな脳の獲得 |昆虫の脳)

    一色出版  2018.12  ( ISBN:9784909383051

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    Total pages:520   Responsible for pages:129-168   Language:Japanese Book type:Scholarly book

  3. Hearing in Drosophila, In: Insect Hearing

    Azusa Kamikouchi, Yuki Ishikawa( Role: Joint author)

    Springer Japan  2016 

  4. シロアリの事典

    石川 由希( Role: Joint author ,  第4章カースト分化の生理機構 4.6 兵蟻における神経改変)

    海青社  2012.12  ( ISBN:4860992601

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    Total pages:472  

    ASIN

  5. 研究者が教える動物飼育 第2巻 -昆虫とクモの仲間-

    石川 由希( Role: Joint author ,  オオシロアリ)

    共立出版  2012.5  ( ISBN:4320057198

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    Total pages:224  

    ASIN

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MISC 13

  1. ショウジョウバエにおける聴覚ニューロン群の種特異的な応答特性

    大橋拓朗, 石川由希, 粟崎健, 蘇馬賦, 蘇馬賦, 上川内あづさ, 上川内あづさ

    日本神経化学会大会抄録集(Web)   Vol. 65th   2022

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  2. How does Drosophila elegans prefer the flowers to visit?

    石川由希, 藤井航平, 林優人, 武方宏樹, 田中良弥, 上川内あづさ

    日本生態学会大会講演要旨(Web)   Vol. 69th   2022

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  3. Ecology, genome editing, and genetic tools in the flower-dependent fruit fly Drosophila elegans

    石川由希, 藤井航平, 林優人, 武方宏樹, 田中良弥, 上川内あづさ

    日本分子生物学会年会プログラム・要旨集(Web)   Vol. 44th   2021

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  4. Neuronal mechanisms of evolution of species-specific pheromone preference in Drosophila

    Yuki Ishikawa, Azusa Kamikouchi, Daisuke Yamamoto

    GENES & GENETIC SYSTEMS   Vol. 91 ( 6 ) page: 325 - 325   2016.12

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:GENETICS SOC JAPAN  

    Web of Science

  5. シロアリからショウジョウバエへ : 行動進化メカニズムの理解を目指して

    石川 由希

    比較生理生化学   Vol. 30 ( 2 ) page: 77 - 78   2013.5

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    Language:Japanese  

    CiNii Books

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Presentations 39

  1. 花で繁殖するショウジョウバエの意外に賢い生存/繁殖戦略 Invited

    石川由希, 桂宗広, 川村康平, 佐々木悠真, 白武勝裕

    日本動物学会第95回長崎大会  2024.9.13 

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    Event date: 2024.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  2. Species comparison of whole‐brain single‐cell transcriptomes to explore the molecular mechanisms of behavioral evolution

    Yuki Ishikawa, Yukiko Nakamura, Takuro Ohashi, Haruna Yamakoshi, Shuji Shigenobu, Azusa Kamikouchi

    2023.9.1 

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    Event date: 2023.8 - 2023.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  3. 昆虫における花と色の認識とその分子機構の解明を目指して Invited

    石川 由希, 桂 宗弘, 藤井 航平, 蟻川 謙太郎, 木下 充代

    第45回日本分子生物学会年会  2022.12.2 

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    Event date: 2022.11 - 2022.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  4. Spacial territorial recognition of flower-breeding Drosophila elegans

    Yuki Ishikawa;Yuto Hayashi;Kohei Fujii;Munehiro Katsura;Ryoya Tanaka;Azusa Kamikouchi

    2022.7.1 

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    Event date: 2022.6 - 2022.7

    Language:English   Presentation type:Poster presentation  

  5. カザリショウジョウバエはどのように花を選ぶのか?

    石川 由希, 藤井 航平, 林 優人, 武方 宏樹, 田中 良弥, 上川内 あづさ

    第69回日本生態学会大会  2022.3.14 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

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KAKENHI (Grants-in-Aid for Scientific Research) 13

  1. 全脳1細胞トランスクリプトーム種間比較による脳の進化の分子基盤の解明

    Grant number:24K02075  2024.4 - 2028.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    石川 由希

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    Authorship:Principal investigator 

    Grant amount:\18590000 ( Direct Cost: \14300000 、 Indirect Cost:\4290000 )

    本研究は1細胞トランスクリプトーム解析を用いてショウジョウバエ近縁種の脳を比較し、種間で発現プロファイルの異なる細胞腫や、特定の細胞腫において発現差のある遺伝子を特定する。さらに種差のある細胞腫や遺伝子発現を操作することで、脳の進化をもたらす細胞/分子機構を世界で初めて解明する。

  2. Regulatory mechanism of target recognition with multi-sensory system in a small brain

    Grant number:21468112  2021.10 - 2026.2

    JST 

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    Authorship:Principal investigator 

  3. 神経ネットワークにおける揺らぎと進化的保存性の関係

    Grant number:20H04865  2020.4 - 2022.3

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)

    石川 由希

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    Authorship:Principal investigator 

    Grant amount:\10270000 ( Direct Cost: \7900000 、 Indirect Cost:\2370000 )

    本研究は、神経接続の進化的保存性と揺らぎやすさの相関を検証するために、種間で異なるフェロモン選好性を示すキイロショウジョウバエ(以下、キイロ)とオナジショウジョウバエ(以下、オナジ)を対象として、そのフェロモン選好性の進化の神経機構を解明する。前年度までの公募研究において、私たちはオナジと類似したフェロモン選好性を示すF1雑種に置いて、フェロモン選好性を司る神経回路の機能を種間比較し、F1雑種では求愛に関する機能が正から負へ逆転していること、さらにF1雑種ではほとんどの神経接続が保存されていながら、1箇所の接続のみが失われていることが、GFP再構成法を用いた比較解析を用いて示した。これは、この神経接続の進化的保存性が低いことを示唆している。
    そこで本年度は、この結果がオナジの純系にも当てはまるかを検証するために、該当ニューロン群においてGFP構成法を用いる遺伝学的ツールを導入することを試みた。キイロにおいて該当ニューロンを標識することが知られるゲノム領域と相同な位置にattP配列を導入した結果、オナジにおいても該当ニューロンが正しく標識されることがわかった。そこで次に、このattP配列にphiC31システムを用いてLexA配列の導入を試みた。LexA配列を含むノックインベクターとphiC31インテグラーゼmRNAの胚への導入を約200胚に2回に渡って行ったが、これまで導入された系統は得られていない。phiC31インテグラーゼの発現が弱い可能性を考え、現在phiC31を卵巣特異的に発現させる系統を作成中である。この系統が完成したら、再度LexA配列の導入を行い、Lex系統が得られたら、神経接続の進化的保存性の検証を進める。また、今回進化的保存性が低いことが示唆された神経接続に関して、キイロに経験的摂動を与えた際の揺らぎを定量し、進化的保存性と揺らぎやすさの相関を検証する。

  4. Possible gain/loss of synaptic connection underlying reproductive isolation

    Grant number:19K22453  2019.6 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Ishikawa Yuki

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    Authorship:Principal investigator 

    Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )

    Differentiation of mating preference drives further phenotypic evolution through reproductive isolation and sexual selection. Changes in information processing in neural network are thought to be important for the preference differentiation, but the mechanism has been largely unknown due to the complexity of the neural circuitry. In this study, we aimed to elucidate this mechanism using two related Drosophila species as a model, in which reproductively isolated by the difference of pheromone preference. We compared the morphology, function and synaptic connections of seven different neural populations that constitute the neural circuitry associated with pheromone preference between Drosophila melanogaster and hybrids, and identified the possible lost of synaptic connections lost in hybrids.

  5. Neural basis for evolution of mating preference

    Grant number:18H02488  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Ishikawa Yuki

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    Authorship:Principal investigator 

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

    To unravel the neural basis of the evolution of mate preference, we aimed to elucidate the neural basis of the interspecific differences in the preference for courtship songs in Drosophila melanogaster and D. simulans. We found that the morphological characteristics of the 1st, 2nd, and 3rd order neurons and courtship command neurons are well conserved between the two species. We also compared the song preference of the neural activity of auditory 1st and 2nd order neurons between species and showed that there are slight interspecific differences in the neural response of 2nd order neurons. The results show that the interspecies differences in auditory information processing already exist at the level of neural activity of second-order neurons.

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Teaching Experience (On-campus) 4

  1. 生体構築論講義

    2022

  2. 生物科学実験V

    2022

  3. 生物学実験

    2022

  4. Anatomy and physiology

    2022

 

Social Contribution 1

  1. 第108回 生態学最前線 -昆虫の脳から環境問題まで-

    Role(s):Lecturer

    名古屋市立大学 大学院システム自然科学研究科  サイエンスカフェin名古屋  2016.4

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    Audience: Junior students, High school students, College students, Graduate students, General

    Type:Lecture

    中区栄ナディアパーク7階 7th Cafeにおいて、『生態学最前線』と題してさまざまな分野と融合しつつある生態学の最前線に関する話題を提供した。名古屋市大の村瀬香准教授と共演。