Faculty Profiles - NAKAMURA Shota

Papers - NAKAMURA Shota

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Prognostic Impact of the Tumor Size Eliminating the Ground Glass Opacity Component: Modified Clinical T Descriptors of the TNM Classification of Lung Cancer Reviewed

Shota Nakamura, Takayuki Fukui, Tetsuo Taniguchi, Noriyasu Usami, Koji Kawaguchi, Futoshi Ishiguro, Akihiro Hirakawa, and Kohei Yokoi

Vol. 8 ( 12 ) page： 1551-1557 2013.12

Multilocular Thymic Cyst Associated with Thymoma: A Clinicopathologic Study of 20 Cases With an Emphasis on the Pathogenesis of Cyst Formation. Reviewed

Nakamura S, Tateyama H, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Mizuno T, Ishiguro F, Yokoi K

Am J Surg Pathol;36:1857-64 page： 10.1097/PAS.0b013e31826320c4 2012.12

Solitary fibrous tumour of the mediastinal pleura: the origin detected with three-dimensional computed tomography angiography. Reviewed

Nakamura S, Taniguchi T and Yokoi K

Eur J Cardio-Thorac Surg Vol. 43 page： e92 2013.1

[Pulmonary Cryptococcosis Treated with Antifungal Drugs After Surgical Resection:Report of a Case].

Takaki Fujimura, Shota Nakamura, Ryota Kiriyama, Hironori Oyamatsu, Takehiko Okagawa, Jun Fukami, Sejiro Niimi, Toyofumi Fengshi Chen-Yoshikawa

Kyobu geka. The Japanese journal of thoracic surgery Vol. 77 ( 13 ) page： 1135 - 1140 2024.12

Language：Japanese Publishing type：Research paper (scientific journal)

The patient is an 81-year-old man. He underwent surgery for pancreatic body cancer in 201X and was followed up every six months with computed tomography (CT) imaging. A CT scan in 201X+5 showed a new nodule in S6 of the right lung. The nodule grew in the latter half of the year and was diagnostically resected on suspicion of being a metastatic lung tumor. A histopathological examination of the resected lung revealed pulmonary cryptococcosis. The postoperative course was uneventful, and the patient was treated with fluconazole 200 mg/day for six months. The patient is currently alive and recurrence-free three years after surgery. Pulmonary cryptococcosis can recur and may be complicated by meningitis. Postoperative antifungal therapy should be considered because of the poor prognosis of meningitis. Postoperative treatment should be performed with caution, especially in patients who are susceptible to infection, have positive preoperative serum cryptococcal antigen levels or have a high standardized uptake value (SUV) max on positron emission tomography (PET)-CT scanning, and are considered to have high fungal loads or activity.

PubMed

Diagnostic Value and Safety of Addition of Transbronchial Needle Aspiration to Transbronchial Biopsy Through Endobronchial Ultrasonography Using a Guide Sheath Under Virtual Bronchoscopic Navigation for the Diagnosis of Peripheral Pulmonary Lesions. International journal

Takayasu Ito, Kazuki Nishida, Shingo Iwano, Shotaro Okachi, Shota Nakamura, Masahiro Morise, Chen Yoshikawa Fengshi Toyofumi, Makoto Ishii

Journal of bronchology & interventional pulmonology Vol. 31 ( 4 ) 2024.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The diagnostic yield of peripheral pulmonary lesions (PPLs) through endobronchial ultrasonography with a guide sheath transbronchial biopsy (EBUS-GS TBB) under virtual bronchoscopic navigation is unsatisfactory because radial EBUS probe is not always located within the lesion. Transbronchial needle aspiration with a guide sheath (GS-TBNA) has the potential to overcome the lower diagnostic yield by improving the relationship between the probe and the lesion and enabling repeated sampling while maintaining the location of a GS near the lesion. However, there are few data regarding the diagnostic yield and safety for diagnosing PPLs in this procedure. METHODS: We retrospectively analyzed consecutive 363 lesions (83 lesions underwent GS-TBNA/EBUS-GS TBB and 280 lesions underwent EBUS-GS TBB) at our institution between April 1, 2019 and March 31, 2022. We investigated the diagnostic efficacy and complications of GS-TBNA/EBUS-GS TBB and compared them with those of EBUS-GS TBB. RESULTS: The lesion size, distance from the hilum, presence of bronchus leading to the lesion, and EBUS images during the examination differed significantly between the two procedures. Logistic regression analysis adjusted for these 4 covariates revealed that GS-TBNA/EBUS-GS TBB was a significant factor affecting the diagnostic success of PPLs compared with EBUS-GS TBB (odds ratio=2.43, 95% CI=1.16-5.07, P=0.018). Neither procedure differed significantly in terms of complications (6.0% vs. 5.7%, P>0.999). CONCLUSION: GS-TBNA performed in addition to EBUS-GS TBB might be a promising sampling method for improving the diagnostic yield for PPLs without increasing the incidence of complications.

DOI： 10.1097/LBR.0000000000000984

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PubMed

Circular polarization measurement for individual gamma rays in capture reactions with intense pulsed neutrons

Endo S., Abe R., Fujioka H., Ino T., Iwamoto O., Iwamoto N., Kawamura S., Kimura A., Kitaguchi M., Kobayashi R., Nakamura S., Oku T., Okudaira T., Okuizumi M., Omer M., Rovira G., Shima T., Shimizu H.M., Shizuma T., Taira Y., Takada S., Takahashi S., Yoshikawa H., Yoshioka T., Zen H.

European Physical Journal A Vol. 60 ( 8 ) 2024.8

Language：English Publishing type：Research paper (scientific journal) Publisher：European Physical Journal A

Measurements of circular polarization of γ-ray emitted from neutron capture reactions provide valuable information for nuclear physics studies. The spin and parity of excited states can be determined by measuring the circular polarization from polarized neutron capture reactions. Furthermore, the γ-ray circular polarization in a neutron capture resonance is crucial for studying the enhancement effect of parity nonconservation in compound nuclei. The γ-ray circular polarization can be measured using a polarimeter based on magnetic Compton scattering. A polarimeter was constructed, and its performance indicators were evaluated using a circularly polarized γ-ray beam. Finally, as a demonstration, the γ-ray circular polarization was measured in 32S(n,γ)33S reactions with polarized neutrons.

DOI： 10.1140/epja/s10050-024-01392-6

Scopus

Development of a machine learning-based risk model for postoperative complications of lung cancer surgery.

Yuka Kadomatsu, Ryo Emoto, Yoko Kubo, Keita Nakanishi, Harushi Ueno, Taketo Kato, Shota Nakamura, Tetsuya Mizuno, Shigeyuki Matsui, Toyofumi Fengshi Chen-Yoshikawa

Surgery today 2024.6

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To develop a comorbidity risk score specifically for lung resection surgeries. METHODS: We reviewed the medical records of patients who underwent lung resections for lung cancer, and developed a risk model using data from 2014 to 2017 (training dataset), validated using data from 2018 to 2019 (validation dataset). Forty variables were analyzed, including 35 factors related to the patient's overall condition and five factors related to surgical techniques and tumor-related factors. The risk model for postoperative complications was developed using an elastic net regularized generalized linear model. The performance of the risk model was evaluated using receiver operating characteristic curves and compared with the Charlson Comorbidity Index (CCI). RESULTS: The rate of postoperative complications was 34.7% in the training dataset and 21.9% in the validation dataset. The final model consisted of 20 variables, including age, surgical-related factors, respiratory function tests, and comorbidities, such as chronic obstructive pulmonary disease, a history of ischemic heart disease, and 12 blood test results. The area under the curve (AUC) for the developed risk model was 0.734, whereas the AUC for the CCI was 0.521 in the validation dataset. CONCLUSIONS: The new machine learning model could predict postoperative complications with acceptable accuracy. CLINICAL REGISTRATION NUMBER: 2020-0375.

DOI： 10.1007/s00595-024-02878-y

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PubMed

CHST4 Gene as a Potential Predictor of Clinical Outcome in Malignant Pleural Mesothelioma. International journal

Shoji Okado, Taketo Kato, Yuki Hanamatsu, Ryo Emoto, Yoshito Imamura, Hiroki Watanabe, Yuta Kawasumi, Yuka Kadomatsu, Harushi Ueno, Shota Nakamura, Tetsuya Mizuno, Tamotsu Takeuchi, Shigeyuki Matsui, Toyofumi Fengshi Chen-Yoshikawa

International journal of molecular sciences Vol. 25 ( 4 ) 2024.2

Language：English Publishing type：Research paper (scientific journal)

Malignant pleural mesothelioma (MPM) develops primarily from asbestos exposures and has a poor prognosis. In this study, The Cancer Genome Atlas was used to perform a comprehensive survival analysis, which identified the CHST4 gene as a potential predictor of favorable overall survival for patients with MPM. An enrichment analysis of favorable prognostic genes, including CHST4, showed immune-related ontological terms, whereas an analysis of unfavorable prognostic genes indicated cell-cycle-related terms. CHST4 mRNA expression in MPM was significantly correlated with Bindea immune-gene signatures. To validate the relationship between CHST4 expression and prognosis, we performed an immunohistochemical analysis of CHST4 protein expression in 23 surgical specimens from surgically treated patients with MPM who achieved macroscopic complete resection. The score calculated from the proportion and intensity staining was used to compare the intensity of CHST4 gene expression, which showed that CHST4 expression was stronger in patients with a better postoperative prognosis. The median overall postoperative survival was 107.8 months in the high-expression-score group and 38.0 months in the low-score group (p = 0.044, log-rank test). Survival after recurrence was also significantly improved by CHST4 expression. These results suggest that CHST4 is useful as a prognostic biomarker in MPM.

DOI： 10.3390/ijms25042270

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PubMed

2スコープ法を活用したEWSによる気管支充填術が有効であった大量喀血の1例

馬場智也, 伊藤貴康, 佐藤圭樹, 速井俊策, 神山潤二, 森瀬昌宏, 若原恵子, 石井誠, 中村彰太, 芳川豊史, 徳田順之

気管支学 Vol. 46 ( 1 ) page： 65 - 65 2024.1

A Case of Incidentally Discovered Congenital Complete Pericardial Defect during Lobectomy for Lung Cancer: A Case Report and Literature Review.

Tomohiro Setogawa, Taketo Kato, Hiroki Watanabe, Shota Nakamura, Tetsuya Mizuno, Toyofumi Fengshi Chen-Yoshikawa

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia Vol. 30 ( 1 ) 2024

Language：English Publishing type：Research paper (scientific journal)

An 82-year-old male patient underwent a left upper lobectomy with anterolateral thoracotomy for lung cancer. Although a complete left-pericardial defect was observed during surgery, the pericardial repair was not performed because the left lower lobe remained and the heart was considered stable. Postoperative pathological examination revealed primary synchronous double-lung squamous-cell carcinoma (pathological stage pT2a(2)N0M0 stage IB). He was discharged without complications on postoperative day 8. Leftward displacement of the heart and left diaphragmatic elevation, suspected of phrenic-nerve paralysis, were found in the chest X-ray after discharge. However, the patient's overall condition remained unaffected at the 5-month postoperative follow-up. To assess the need for pericardial repair, we compared cases of complete pericardial defects observed during lobectomy or pneumonectomy reported in the literature. Only one of 12 cases occurred postoperative death despite pericardial repair, and that case combined pectus excavatum and pericardial defects. Our assessment indicated that pericardial repair might not be necessary, excluding complex cases.

DOI： 10.5761/atcs.cr.24-00041

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[Postoperative Complications of Open Window Thoracostomy:Report of a Case].

Ito T, Nakamura S, Okado S, Sato K, Fukumoto K, Chen-Yoshikawa TF

Kyobu geka. The Japanese journal of thoracic surgery Vol. 76 ( 12 ) page： 1069 - 1072 2023.11

Cadaver surgical training for brain-dead donor lung procurement: Educational note Reviewed International journal

Shota Nakamura, Harushi Ueno, Masato Mutsuga, Toyofumi F. Chen-Yoshikawa

JTCVS Techniques Vol. 21 page： 261 - 264 2023.10

Complete visualization using indocyanine green in thoracic surgery for pulmonary sequestration. International journal

Keita Nakanishi, Yuka Kadomatsu, Harushi Ueno, Taketo Kato, Shota Nakamura, Tetsuya Mizuno, Toyofumi Fengshi Chen-Yoshikawa

Journal of thoracic disease Vol. 15 ( 10 ) page： 5714 - + 2023.10

Language：English Publishing type：Research paper (scientific journal)

Preoperative three-dimensional computed tomography (CT) facilitates accurate identification of aberrant systemic arteries in thoracic surgery for pulmonary sequestration (PS). Furthermore, the boundary between normal and sequestrated lungs can be visualized using the spread of fluorescent indocyanine green (ICG) when performing surgery for PS. This study aimed to determine how to completely visualize anatomical variations, safely treat aberrant arteries, remove only sequestrated lungs, and perform minimally invasive surgery for PS. Seventeen patients underwent lung resection for intralobar PS at our institution between 2009 and 2022. We retrospectively reviewed the surgical outcomes and intraoperative images using ICG to assess the efficacy and feasibility of near-infrared fluorescence imaging. Since 2019, intraoperative near-infrared fluorescence imaging with ICG has been used in six patients, including four females and two males (median age, 56 years), to visualize the boundary between normal and sequestrated lungs. Aberrant arteries were identified using preoperative three-dimensional CT, and the boundary between sequestrated and normal lungs could be clearly delineated intraoperatively using ICG in all cases. The median operative time was 145 min (range, 88-167 min), and the median blood loss was 5 mL (range, 1-191 mL). The overlay mode using near-infrared thoracoscopy, which merges visible light images with fluorescent images, was safer and more useful than conventional thoracoscopy for delineating boundaries with electrocautery. No intraoperative or postoperative complications occurred. The median postoperative hospital stay was 5 days (range, 3-7 days). Intraoperative identification of the boundary between normal and sequestrated lungs using ICG was simple and feasible. We suggested that this technique was effective for lesion resection and normal lung preservation during surgery for intralobar PS.

DOI： 10.21037/jtd-23-892

Web of Science

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Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice

Sahashi, S; Shimada, K; Takagi, Y; Aoki, T; Kunou, S; Sakamoto, A; Murase, A; Furukawa, K; Kagaya, Y; Yamaga, Y; Takai, M; Tokuyama, K; Shimada, S; Nakamura, S; Kiyoi, H

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 118 ( 2 ) page： 221 - 230 2023.8

Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Hematology

Patient-derived xenograft (PDX) mouse models are useful for deepening our understanding of the biology of malignant lymphoma; however, factors associated with the success of the PDX lymphoma model are largely unknown. We retrospectively analyzed the characteristics of 66 xenotransplantations from 65 patients. In all, 43 (65%) specimens were obtained from patients aged > 60 years, and 42 (64%) specimens were obtained at diagnosis. Specimens were obtained from patients with the following diseases: diffuse large B-cell lymphoma (n = 30), intravascular large B-cell lymphoma (n = 12), follicular lymphoma (n = 8), peripheral T-cell lymphoma (n = 7), mantle cell lymphoma (n = 2), and other (n = 7). The specimens were sourced mainly from bone marrow (n = 31, 47%) and extranodal tumors (n = 13, 20%). Engraftment was successful in 33/66 (50%) xenotransplantations. The median age of patients who provided successful specimens was significantly higher than that for unsuccessful specimens (p = 0.013). Specimens with a high proportion of tumor cells in the graft and those obtained from patients with relapsed/refractory disease showed higher tendencies toward successful engraftment. Taken together, these data suggest that tumor cells with a highly malignant potential might have a high likelihood of engraftment.

DOI： 10.1007/s12185-023-03604-z

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[Robot-assisted Extended Thymectomy via a Bilateral Approach for Patients with Myasthenia Gravis]. Invited

Shota Nakamura, Keita Nakanishi, Yuka Kadomatsu, Harushi Ueno, Taketo Kato, Toyofumi F Chen-Yoshikawa

Kyobu geka. The Japanese journal of thoracic surgery Vol. 76 ( 7 ) page： 523 - 527 2023.7

Authorship：Lead author,　Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)

Extended thymectomy is a procedure to remove the thymus gland and surrounding adipose tissue, while the traditional approach via a median sternotomy, minimally invasive approaches such as video-assisted thoracoscopic surgery (VATS) and robot-assisted thoracoscopic surgery (RATS) have been adopted. This report described the technique of bilateral approach for extended thymectomy in patients with myasthenia gravis (MG) by robot-assisted thoracoscopic surgery, and also showed the perioperative outcomes and postoperative exacerbation rates of 11 patients. In most patients, score of MG symptom were reduced and levels of anti-acetylcholine receptor antibodies declined postoperatively. In a small number of cases, the safety and efficacy of a RATS bilateral approach for extended thymectomy were confirmed.

PubMed

Clinical application of resection process map as a novel surgical guide in thoracic surgery. International journal

Yuka Kadomatsu, Megumi Nakao, Harushi Ueno, Shota Nakamura, Koichi Fukumoto, Toyofumi Fengshi Chen-Yoshikawa

Interdisciplinary cardiovascular and thoracic surgery Vol. 36 ( 4 ) 2023.4

Language：English Publishing type：Research paper (scientific journal)

Resection Process Map (RPM) is a surgical simulation system that uses preoperative three-dimensional computed tomography. Unlike the usual static simulation, this system provides surgeons an individualized dynamic deformation of the lung parenchyma and vessels. RPM was first introduced in 2020. Although the intraoperative usefulness of this system has been evaluated experimentally, there have been no reports on its clinical use. Herein, we presented in detail the first experience on RPM during robot-assisted anatomical lung resection in the real clinical setting.

DOI： 10.1093/icvts/ivad059

Web of Science

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ASO Author Reflections: Pleural Thickness in Patients with Malignant Pleural Mesothelioma. International journal

Shota Nakamura, Toshinari Ito, Toyofumi Fengshi Chen-Yoshikawa

Annals of surgical oncology Vol. 30 ( 3 ) page： 1584 - 1585 2023.3

ASO Visual Abstract: Impact of Pleural Thickness on the Occurrence of Postoperative Complications in Patients with Malignant Pleural Mesothelioma. International journal

Toshinari Ito, Shota Nakamura, Yuka Kadomatsu, Harushi Ueno, Taketo Kato, Naoki Ozeki, Koichi Fukumoto, Toyofumi Fengshi Chen-Yoshikawa

Annals of surgical oncology Vol. 30 ( 3 ) page： 1586 - 1586 2023.3

A novel system applying artificial intelligence in the identification of air leak sites International journal

Yuka Kadomatsu, Megumi Nakao, Harushi Ueno, Shota Nakamura, Toyofumi Fengshi Chen-Yoshikawa

JTCVS Techniques Vol. 15 page： 181 - 191 2022.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

Objective: Prolonged air leak is the most common complication of thoracic surgery. Intraoperative leak site detection is the first step in decreasing the risk of leak-related postoperative complications. Methods: We retrospectively reviewed the surgical videos of patients who underwent lung resection at our institution. In the training phase, deep learning-based air leak detection software was developed using leak-positive endoscopic images. In the testing phase, a different data set was used to evaluate our proposed application for each predicted box. Results: A total of 110 originally captured and labeled images obtained from 70 surgeries were preprocessed for the training data set. The testing data set contained 64 leak-positive and 45 leak-negative sites. The testing data set was obtained from 93 operations, including 58 patients in whom an air leak was present and 35 patients in whom an air leak was absent. In the testing phase, our software detected leak sites with a sensitivity and specificity of 81.3% and 68.9%, respectively. Conclusions: We have successfully developed a deep learning-based leak site detection application, which can be used in deflated lungs. Although the current version is still a prototype with a limited training data set, it is a novel concept of leak detection based entirely on visual information.

DOI： 10.1016/j.xjtc.2022.06.011

Web of Science

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Chest three-dimensional-computed tomography imaging data analysis for the variation of exercise capacity after lung lobectomy. International journal

Naoki Ozeki, Shingo Iwano, Shota Nakamura, Koji Kawaguchi, Yota Mizuno, Takayuki Inoue, Motoki Nagaya, Toyofumi Fengshi Chen-Yoshikawa

Clinical physiology and functional imaging Vol. 42 ( 5 ) page： 362 - 371 2022.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Postoperative loss of exercise capacity and pulmonary function is a major concern among lung cancer patients. In this study, the time for a stair-climbing to 12-m height was used to investigate whether preoperative chest 3D-computed tomography (CT) could be a useful tool for predicting postoperative variations in exercise capacity and pulmonary function. METHODS: Seventy-eight patients undergoing lobectomy for suspected stage I lung cancer were prospectively enroled. Preoperatively, lobe volume and low attenuation volume (LAV) were evaluated using the SYNAPSE VINCENT system. Preoperative data on stair-climbing time, spirometry and diffusing capacity of the lung for carbon monoxide (DLCO ) at baseline and 6-month postoperative data were used to evaluate variations in exercise capacity and pulmonary function. Maximal oxygen uptake (VO2 t) was evaluated based on the stair-climbing time. RESULTS: Significant differences in the variation of exercise capacity at 6 months postoperatively were found between the groups categorized by target lobe volume and LAV status: The large volume/LAV (+) group had a greater decline in VO2 t. Mean loss of VO2 t was -6.2%, -1.4%, -1.6% and -0.1% in the large volume/LAV (+), large volume/LAV (-), small volume/LAV (+) and small volume/LAV (-) groups, respectively. The large volume/LAV (-) group had a greater decline in forced expiratory volume in 1 s. The small volume/LAV (+) group showed a reduced decline in the DLCO . CONCLUSIONS: Analysis of chest 3D-CT scans is a potential tool for predicting the loss of exercise capacity and pulmonary function after lung lobectomy.

DOI： 10.1111/cpf.12777

Web of Science

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Papers - NAKAMURA Shota