横浜舞岡病院

2008.4 - 2009.3

Mayo Clinic   Neuropathology Laboratory   Research Fellow

2006.4 - 2008.3

日本内科学会

REM sleep without atonia may help diagnose Lewy body disease in middle-aged and older patients with somatic symptom disorder. Reviewed

Munechika T, Fujishiro H, Okuda M, Iwamoto K, Torii Y, Iritani S, Ozaki N.

Psychogeriatrics   Vol. 17   page： 61-69   2017

Effect of aripiprazole augmentation for the depressive symptoms changes with progression of Lewy body disease. Reviewed

Iwamoto K, Fujishiro H, Ozaki N

Psychiatry Clin Neurosci   Vol. 71   page： 74-75   2017

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Reviewed

Fujishiro H, Okuda M, Iwamoto K, Miyata S, Otake H, Noda A, Iritani S, Ozaki N.

Int J Geriatr Psychiatry   Vol. 32   page： 397-406   2017

Risk of alcohol use relapse after liver transplantation for alcoholic liver disease. Reviewed

Onishi Y,Kimura H, Hori T, Kishi S, Kamei H, Kurata N, Tsuboi C, Yamaguchi N, Takahashi M, Sunada S, Hirano M, Fujishiro H, Okada T, Ishigami M, Goto H, Ozaki N, Ogura Y.

World J Gastroenterol   Vol. 23 ( 5 ) page： 869-875   2017

Neuropeptide Y neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia. Reviewed

Morosawa S, Iritani S, Fujishiro H, Sekiguchi H, Torii Y, Habuchi C, Kuroda K, Kaibuchi K, Ozaki N.

Neuropeptides   Vol. 62 ( 27 ) page： 35   2017

Parasomnia overlap disorder caused by paroxetine. Reviewed

Esaki Y, Kitajima T, Fujishiro H, Fujita S, Hirose M, Watanabe A, Iwata N.

Sleep Biol Rhythms     2017

Successful Post-Transplant Psychiatric Interventions During Long-Term Follow-Up of Patients Receiving Liver Transplants for Alcoholic Liver Disease. Reviewed

Kimura H, Onishi Y, Kishi S, Kurata N, Ogiso S, Kamei H, Tsuboi C, Yamaguchi N, Shiga A, Kondo M, Yokoyama Y, Takasato F, Fujishiro H, Ishizuka K, Okada T, Ogura Y, Ozaki N.

Am J Case Rep   Vol. 18   page： 1215-1219   2017

Risk factors for elevated liver enzymes during refeeding of severely malnourished patients with eating disorders: retrospective cohort study. Reviewed

Imaeda M, Tanaka S, Fujishiro H, Kato S, Ishigami M, Kawano N, Katayama H, Kohmura K, Ando M, Nishioka K, Ozaki N.

J Eating Disord   Vol. 4   page： 37   2017

Hypochondriasis as early manifestation in dementia with Lewy bodies: an autopsied case report. Reviewed

Fujishiro H, Iritani S, Sekiguchi H, Habuchi C, Torii Y, Matsunaga S, Ozaki N, Yoshida M, Fujita K.

Psychogeriatrics   Vol. 16 ( 2 ) page： 139-144   2016

Cognitive dysfunction in patients with very mild Alzheimer's disease and amnestic mild cognitive impairment showing hemispheric asymmetries of hypometabolism on 18F-FDG PET. Reviewed

Murayama N, Ota K, Kasanuki K, Kondo D, Fujishiro H, Fukase Y, Tagaya H, Sato K, Iseki E.

Int J Geriatr Psychiatry     2016

Prediction of later clinical course by a specific glucose metabolic pattern in non-demented patients with probable REM sleep behavior disorder admitted to a memory clinic: A case study. Reviewed

Ota K, Fujishiro H, Kasanuki K, Kondo D, Chiba Y, Murayama N, Arai H, Sato K, Iseki E.

Psychiatry Res     2016

Evaluation of titers of antibodies against peptides of subunits NR1 and NR2B of glutamate receptor by enzyme-linkedd immunosorbent assay in psychiatric patients with anti-thyroid antibodies. Reviewed

Ikura T, Katsuse O, Chiba Y, Takahashi Y, Fujishiro H, Kamada A, Saito T, Hirayasu Y.

Neurosci Lett     2016

Effectiveness of low-dose pregabalin in three patients with Lewy body disease and central neuropathic pain. Reviewed

Ukai K, Fujishiro H, Ozaki N

Psychogeriatrics     2016

Characteristics of mild cognitive impairment tending to convert into Alzheimer's disease or dementia with Lewy bodies: A follow-up study in a memory clinic. Reviewed

Kondo D, Ota K, Kasanuki K, Fujishiro H, Chiba Y, Murayama N, Sato K, Hirayasu Y, Arai H, Iseki E.

J Neurol Sci     2016

Similarity of symptoms between transient epileptic amnesia and Lewy body disease. Reviewed

Ukai K, Fujishiro H, Watanabe M, Kosaka K, Ozaki N.

Psychogeriatrics     2016

An autopsy case of cortical superficial siderosis with prolonged abnormal behavior. Reviewed

Torii Y, Iritani S, Fujishiro H, Sekiguchi H, Habuchi C, Umeda K, Matsunaga S, Mimuro M, Ozaki N, Yoshida M, Fujita K.

Neuropathology     2016

An open-labeled trial of ramelteon in idiopathic REM sleep behavior disorder. Reviewed

Esaki Y, Kitajima T, Koike S, Fujishiro H, Iwata Y, Tsuchiya A, Hirose M, Iwata N.

J Clin Sleep Med   Vol. 12 ( 5 ) page： 689-693   2016

Immunohistochemical evaluation of the GABAergic neuronal system in the prefrontal cortex of a DISC 1 knockout mouse model of schizophrenia. Reviewed

Umeda , Iritani S, Fujishiro H, Sekiguchi H, Torii Y, Habuchi C, Kuroda K, Kaibuchi K, Ozaki N

Synapse   Vol. 70 ( 12 ) page： 508-518   2016

Postoperative psychiatric complications in living liver donors. Reviewed

Kimura H, Onishi Y, Sunada S, Kishi S, Suzuki N, Tsuboi C, Yamaguchi N, Imai H, Kamei H, Fujishiro H, Okada T, Ishigami M, Ogura Y, Kiuchi T, Ozaki N.

Transplantation Proceedings   Vol. 47   page： 1860-1865   2015.6

Impairde heart rate variability in patients with dementia with Lewy bodies: Efficacy of electrocardiogram as a supporting diagnostic marker. Reviewed

Kasanuki K, Iseki E, Fujishiro H, Ando S, Sugiyama H, Kitazawa M, Chiba Y, Sato K, Arai H.

Parkinsonism Relat Disord   Vol. 21 ( 7 ) page： 749-754   2015.4

Lymphopenia helps early diagnosis of systemic lupus erythematosus for patients with psychosis as an initial symptom.

Chiba Y, Katsuse O, Fujishiro H, Kamada A, Saito T, Ikura T, Takahashi Y, Kunii M, Takeno M, Hirayasu Y.

Psychosomatics   Vol. 56   page： 85-88   2015

Prodromal dementia with Lewy bodies. Reviewed

Fujishiro H, Nakamura S, Sato K, Iseki E.

Geriatr Gerontol Int     2015

Autopsy-confirmed hippocampal-sparing Alzheimer's disease with delusional jealousy as initial manifestation. Reviewed

Fujishiro H, Iritani S, Hattori M, Sekiguchi H, Matsunaga S, Habuchi C, Torii Y, Umeda K, Ozaki N, Yoshida M, Fujita K.

Psychogeriatrics     2015

Long-term efficacy of donepezil for relapse of visual hallucinations in patients with dementia with Lewy bodies. Reviewed

Ukai K, Fujishiro H, Iritani S, Ozaki N.

Psychogeriatrics     2015

Clinical profiles of dementia with Lewy bodies with and without Alzheimer's disease-like hypometabolism. Reviewed

Chiba Y, Fujishiro H, Ota K, Kasanuki K, Arai H, Hirayasu Y, Sato K, Iseki E.

Int J Geriatr Psychiatry   Vol. 30 ( 3 ) page： 316-323   2015

Diagnostic Accuracy of ¹²³I-Meta-iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study. Reviewed

Yoshita M, Arai H, Arai H, Arai T, Asada T, Fujishiro H, Hanyu H, Iizuka O, Iseki E, Kashihara K, Kosaka K, Maruno H, Mizukami K, Mizuno Y, Mori E, Nakajima K, Nakamura H, Nakano S, Nakashima K, Nishio Y, Orimo S, Samuraki M, Takahashi A, Taki J, Tokuda T, Urakami U, Utsumi K, Wada K, Washimi Y, Yamashina S, Yamasaki J, Yamada M.

PLoS ONE   Vol. 10 ( 3 ) page： e0120540   2015

Visuopercertual assessments for differentiating dementia with Lewy bodies and Alzheimer's disease: illusory contours and other neuropsychological examinations.

Ota K, Murayama N, Kasanuki K, Kondo D, Fujishiro H, Arai H, Sato K, Iseki E.

Arch Clin Neuropsychol   Vol. 30 ( 3 ) page： 256-263   2015

Cardiac 123I- metaiodobenzylguanidine scintigraphy in elderly depressed patients. Reviewed

Fujishiro H

Psychiatry Clin Neurosci   Vol. 68   page： 652   2014

Effects of gabapentin enacarbil on restless legs syndrome and leg pain in dementia with Lewy bodies. Reviewed

Fujishiro H

Psychogeriatrcs   Vol. 14 ( 2 ) page： 132-134   2014

Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies. Reviewed

Kasanuki K, Iseki E, Kondo D, Fujishiro H, Minegishi M, Sato K, Katsuse O, Hino H, Kosaka K, Arai H.

Neurosci Lett   Vol. 569   page： 68-73   2014

Three presenile patients in which neuropsychological and neuroimaging examinations suggest possible progression to dementia with Lewy bodies. Reviewed

Ota K, Iseki E, Murayama N, Chiba Y, Fujishiro H, Kasanuki K, Manabe Y, Arai H, Sato K.

Psychogeriatrics   Vol. 14 ( 1 ) page： 72-80   2014

Primary visual metabolism and REM sleep behavior disorder in dementia with Lewy bodies. Reviewed

Chiba Y, Iseki E, Fujishiro H, Ota K, Kasanuki K, Arai H, Hirayasu Y, Sato K.

Psychiatry Clin Neurosci   Vol. 68 ( 2 ) page： 137-144   2014

Diversity of pathological features other than Lewy bodies in familial Parkinson's disease due to SNCA mutations. Reviewed

Fujishiro H, Imamura AY, Lin WL, Uchikado H, Mark MH, Golbe LI, Markopoulou K, Wszolek ZK, Dickson DW.

Am J Neurodegener Dis   Vol. 29   page： 266-275   2013

Intelligence or years of education: which is more correlated with memory function in Japanese normal elderly subjects?

Murayama N, Iseki E, Tagaya H, Ota K, Fujishiro H, Arai H, Sato K.

Psychogeriatrics   Vol. 13   page： 9-16   2013

Neuropsychological detection of early stage of amnestic MCI without objective memory impairment.h Lewy bodies. Reviewed

Murayama N, Tagaya H, Ota K, Fujishiro H, Iseki E, Manabe Y, Sato K, Iseki E.

Psychiatry Clin Neurosci   Vol. 35   page： 98-105   2013

Dementia with Lewy bodies: early diagnostic challenges. Reviewed

Fujishiro H, Iseki E, Nakamura S, Kasanuki K, Chiba Y, Ota K, Murayama N, Sato K.

Psychogeriatrics   Vol. 13   page： 128-138   2013

Effectiveness of ramelteon for visual hallucinations in dementia with Lewy bodies: four cases report.

Kasanuki K, Iseki E, Nishida Y, Fujishiro H, Chiba Y, Sato K, Arai H.

J Clin Psychopharmacol   Vol. 33   page： 581-583   2013

A follow up study of non-demented patients with primary visual cortical hypometabolism: Prodromal dementia with Lewy bodies. Reviewed

Fujishiro H, Iseki E, Kasanuki K, Chiba Y, Ota K, Murayama N, Sato K.

J Neurol Sci   Vol. 334   page： 48-54   2013

Levodopa treatment and mood fluctuation in dementia with Lewy bodies: a case report. Reviewed

Fujishiro H, Kasanuki K, Nakamura S

Psychogeriatrics   Vol. 13   page： 250-253   2013

Glucose hypometabolism in primary visual cortex is commonly associated with clinical features of dementia with Lewy bodies regardless of cognitive conditions.

Fujishiro H, Iseki E, Kasanuki K, Murayama N, Ota K, Suzuki M, Sato K.

Int J Geriatr Psychiatry   Vol. 27   page： 1138-1146   2012

Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients dementia with Lewy bodies.

Kasanuki K, Iseki E, Fujishiro H, Yamamoto R, Higashi S, Minegishi M, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H.

J Neurol Sci   Vol. 314   page： 111-119   2012

Rapid eye movement disorder and subtypes in autopsy-confirmed dementia with Lewy bodies.

Dugger BN, Boeve BF, Murray ME, Parisi JE, Fujishiro H, Dickson DW, Ferman TJ.

Mov Disord   Vol. 27   page： 72-78   2012

Early detection of dementia with Lewy bodies in patients with amnestic mild cognitive impairment using cardiac MIBG scintigraphy.

Fujishiro H, Nakamura S, Kitazawa M, Sato K, Iseki E.

J Neurol Sci   Vol. 315   page： 115-119   2012

Urinary homocysteic acid levels correlate with Mini-Mental State Examination scores in Alzheimer's disease patients.

Hasegawa T, Ichiba M, Matsumoto SE, Kasanuki K, Hatano T, Fujishiro H, Iseki E, Hattori N, Yamada T, Tabira T.

J Alzheimers Dis   Vol. 31   page： 59-64   2012

Retrospective survey of prodromal symptoms in dementia with Lewy bodies: comparison with Alzheimer's disease.

Chiba Y, Fujishiro H, Iseki E, Ota K, Kasanuki K, Hirayasu Y, Sato K.

Dement Geriatr Cogn Disord   Vol. 33   page： 273-281   2012

Validation of the Revised DLB Clinical Consensus Criteria: RBD Improves Classification of Autopsy-Confirmed DL

Ferman TJ, Boeve BF, Smith GE, Lin Siong-Chi, Silber MH, Pedraza O, Wszolek Z, Graff-Radford NR, Uitti R, Gerpen JV, Pao W, Knopman D, Pankratz VS, Kantarci K, Boot B, Parisi JE, Dugger BN, Fujishiro H, Petersen RC, Dickson DW.

Neurology   Vol. 77   page： 875-882   2011

Incidental Lewy body disease: do some cases represent preclinical dementia with Lewy bodies?

Frigerio R, Fujishiro H, Ahn TB, Josephs KA, Maraganore D, DelleDonne A, Parisi JE, Klos K, Boeve B, Dickson DW, Ahlskog JE.

Neurobiol Aging   Vol. 32   page： 857-863   2011

Gray matter lesions in Nasu-Hakola disease: a report on three autopsy cases.

Aoki N, Tsuchiya K, Togo T, Kobayashi Z, Uchikado H, Katsuse O, Suzuki K, Fujishiro H, Arai T, Iseki E, Kosaka K, Akiyama H, Hirayasu Y.

Neuropathology   Vol. 31   page： 135-143   2011

Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies.

Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, Kabuta T, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H, Wada K, Iseki E.

J Neuropathol Exp Neurol   Vol. 70   page： 264-280   2011

Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia.

Fujishiro H, Iseki E, Higashi S, Kasanuki K, Murayama N, Togo T, Katsuse O, Uchikado H, Aoki N, Kosaka K, Arai H, Sato K.

Neurosci Lett   Vol. 486   page： 19-23   2010

Evidence in favor of Braak staging of Parkinson's disease.

Dickson DW, Uchikado H, Fujishiro H, Tsuboi Y.

Mov Disord   Vol. 25 ( S1 ) page： S78-82   2010

Diffuse occipital hypometabolism on 18F-FDG PET scans in patients with idiopathic REM sleep behavior disorder: prodromal dementia with Lewy bodies?

Fujishiro H, Iseki E, Murayama N, Yamamoto R, Kasanuki K, Higashi S, Suzuki M, Arai H, Sato K.

Psychogeriatrics   Vol. 10   page： 144-152   2010

Construction of a 18F-FDG PET normative database of Japanese healthy elderly subjects and its application to demented and mild cognitive impairment patients.

Iseki E, Murayama N, Yamamoto R, Fujishiro H, Suzuki M, Kawano M, Miki S, Sato K

Int J Geriatr Psychiatry   Vol. 25   page： 352-361   2010

Detection of early amnestic mild cognitive impairment without significant objective memory impairment: a case-controlled study.

Murayama N, Iseki E, Fujishiro H, Yamamoto R, Ota K, Suzuki M, Nagashima K, Arai H, Sato K.

Psychogeriatrics   Vol. 10   page： 62-68   2010

Argyrophilic grain disease with delusions and hallucinations: A pathological study.

20. Asaoka T, Tsuchiya K, Fujishiro H, Arai T, Hasegawa M, Akiyama H , Iseki E, Oda T, Onaya M, Tominaga I.

Psychogeriatrics   Vol. 10   page： 69-76   2010

Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy.

Arai T, Hasegawa M, Nonoka T, Kametani F, Yamashita M, Hosokawa M, Niizato K, Tsuchiya K, Kobayashi Z, Ikeda K, Yoshida M, Onaya M, Fujishiro H, Akiyama H.

Neuropathology   Vol. 30   page： 170-181   2010

Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease.

Frigerio R, Fujishiro H, Maraganore DM, Klos KJ, DelleDonne A, Heckman MG, Crook JE, Josephs KA, Parisi JE, Boeve BF, Dickson DW, Ahlskog JE.

Arch Neurol   Vol. 66   page： 1114-1119   2009

Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease.

Fujishiro H, Uchikado H, Arai T, Hasegawa M, Akiyama H, Yokota O, Tsuchiya K, Togo T, Iseki E, Hirayasu Y

Acta Neuropathol   Vol. 117   page： 151-158   2009

Neuropathology of non-motor features of Parkinson disease.

Dickson DW, Fujishiro H, Orr C, DelleDonne A, Josephs KA, Frigerio R, Burnett M, Parisi JE, Klos KJ, Ahlskog JE.

Parkinsonism Relat Disord   Vol. 15 ( S3 ) page： S1-5   2009

Colocalization of tau and synuclein in olfactory bulb in Alzheimer's disease with amygdala Lewy bodies.

Fujishiro H, Tsuboi Y, Li W, Uchikado H, Dickson DW

Acta Neuropathol   Vol. 116   page： 17-24   2008

Re: In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution.

Dickson DW, Fujishiro H

Neurology   Vol. 70   page： 2087-2088   2008

Incidental Lewy body disease and Parkinson's disease.

DelleDonne A, Klos KJ, Fujishiro H, Zeshan A, Parisi JE, Josephs KA, Frigerio R, Wszolek ZK, Uitti RJ, Ahlskog JE, Dickson DW

Arch Neurol   Vol. 65   page： 1074-1080   2008

Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.

Fujishiro H, Frigerio R, Burnett M, Klos KJ, Josephs KA, DelleDonne A, Parisi JE, Ahlskog JE, Dickson DW

Mov Disord   Vol. 23   page： 1085-1092   2008

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease.

Dickson DW, Fujishiro H, Delledonne A, Menke J, Ahmed Z, Klos KJ, Josephs KA, Frigerio R, Burnett M, Parisi JE, Ahlskog JE

Acta Neuropathol   Vol. 115   page： 437-444   2008

Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy?

Fujishiro H , Ahn TB, Frigerio R, DelleDonne A, Josephs KA, Parisi JE, Ahlskog JE, Dickson DW

Acta Neuropathol   Vol. 116   page： 269-275   2008

Validation of the Neuropathologic Criteria of the Third Consortium for Dementia with Lewy Bodies for Prospectively Diagnosed Cases.

Fujishiro H, Ferman TJ, Boeve BF, Smith GE, Graff-Radford NR, Uitti RJ, Wszolek ZK, Knopman DS, Petersen RC, Parisi JE, Dickson DW

J Neuropathol Exp Neurol   Vol. 67   page： 649-656   2008

Clinical profiles of autopsy-confirmed dementia with Lewy bodies at institutionalization: Comparison with Alzheimer's disease.

Fujishiro H, Umegaki H, Suzuki Y, Isojima D, Akatsu H, Ikari H, Iguchi A, Kosaka K

Psychogeriatrics   Vol. 7   page： 98-103   2007

Vascular Complications in Dementia with Lewy Bodies: A Postmortem Study.

Isojima D, Togo T, Kosaka K, Fujishiro H, Akatsu H, Katsuse O, Iritani S, Matsumoto, Hirayasu Y.

Neuropathology   Vol. 26   page： 293-297   2006

Depletion of neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia

Fujishiro H, Umegaki H, Isojima D, Akatsu H, Iguchi A, Kosaka K.

Acta Neuropathol   Vol. 111   page： 109-114   2006

Dopamine D2 receptor has a role in memory function: Implications for dopamine-acetylcholine interaction in the ventral hippocampus.

Fujishiro H, Umegaki H, Suzuki Y, Oohara-Kurotani S, Yamaguchi Y, Iguchi A.

Psychopharmacology   Vol. 182   page： 253-261   2005

Smell identification test as an indicator for cognitive impairment in Alzheimer's disease.

Suzuki Y, Yamamoto S, Umegaki H, Onishi J, Mogi N, Fujishiro H, Iguchi A.

Int J Geriatr Psychiatry   Vol. 19   page： 727-733   2004