2025/03/18 更新

写真a

リ エンエイ
李 媛英
LI Yuanying
所属
大学院医学系研究科 総合医学専攻 社会生命科学 講師
大学院担当
大学院医学系研究科
学部担当
医学部 医学科
職名
講師

学位 1

  1. 博士(医学) ( 2013年3月   大阪大学 ) 

学歴 1

  1. 大阪大学   医学系研究科   公衆衛生学

    - 2013年3月

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    国名: 日本国

所属学協会 2

  1. 日本公衆衛生学会

  2. 日本疫学会

 

論文 15

  1. A comparison of the diagnostic ability of 1-mm computed tomography and 3-mm magnetic resonance imaging for detecting lateral pelvic lymph node metastases from rectal cancer

    Kobayashi, R; Uehara, K; Ebata, T; Yatsuya, H; Li, YY; Hida, K; Hashiguchi, Y; Ishihara, S; Ogawa, S; Shiomi, A; Kawai, K; Ajioka, Y

    SURGERY TODAY     2025年2月

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    記述言語:英語   出版者・発行元:Surgery Today  

    Aim: The best modality for evaluating lateral pelvic lymph node (LPLN) metastases from rectal cancer remains unclear. This study compared the diagnostic ability of 1-mm computed tomography (CT) and 3-mm magnetic resonance imaging (MRI) in identifying LPLN metastases based on size. Methods: This observational study analyzed not individual patients but 191 sides from 100 rectal cancer patients without preoperative treatment for whom preoperative CT and MRI and corresponding pathological results for LPLNs were available. A swollen LPLN was defined as an LN with a short-axis size of ≥5 mm on 1-mm CT. Results: LPLNs were detected significantly more frequently with 1-mm CT than with 3-mm MRI (p < 0.001). Among the 117 sides without swollen LPLNs, metastasis was observed in 1.7% of patients. In contrast, LPLN metastasis was confirmed in 28.4% of 74 sides with swollen LPLNs. In the evaluation of swollen LPLNs, 3-mm MRI yielded a 34% improvement in the diagnostic performance of LPLN metastasis over 1-mm CT (categorical net reclassification improvement: 0.341, p = 0.045). Conclusions: In conclusion, 1-mm CT should be performed preoperatively to evaluate LPLNs. Further evaluations can be omitted in the absence of swollen LPLNs. In patients with swollen LPLNs, a careful assessment of LPLN metastasis should be conducted via additional MRI, even in early T-stage tumors.

    DOI: 10.1007/s00595-025-03018-w

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  2. Chronotype and leisure-time physical activity among civil servants in Japan: a cross-sectional analysis of the Aichi workers' cohort study Open Access

    Okegawa, R; He, YP; Matsunaga, M; Khine, MT; Li, YY; Kitajima, T; Yatsuya, H; Ota, A

    ARCHIVES OF PUBLIC HEALTH   82 巻 ( 1 ) 頁: 205   2024年11月

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    記述言語:英語   出版者・発行元:Archives of Public Health  

    Background: The association between chronotype and leisure-time physical activity (LTPA) remains unclear. We investigated the difference in regular LTPA and for a sufficient duration between those with evening-type (ET) and morning-type chronotypes (MT). Methods: We conducted a cross-sectional analysis using the data of the Aichi Workers’ Cohort Study. It included 3,221 men (mean [standard deviation] age: 45.0 [11.6] years) and 1,294 women (39.8 [11.2] years). Chronotypes were determined with the reduced version of the Morningness-Eveningness Questionnaire. We calculated the metabolic equivalents (METs) consumed per week based on the four types of LTPA: strolling, brisk walking, light- and moderate-intensity PA, and vigorous-intensity PA. Regular LTPA and for a sufficient duration was defined as doing once or more per week and for 30 min or longer per session, respectively. Logistic regression analysis was conducted separately by sex to calculate odds ratios of ET for regular LTPA and for a sufficient duration, adjusted for age and other factors, for each type of LTPA. Results: ET men consumed fewer total METs per week than MT men (p <.001), although this pattern is not found in women. Compared to MT men, ET men were less likely to be engaged in regular LTPA in all types of LTPA (prevalence and adjusted odds ratio [95% confidence interval]: strolling: 39.1% vs. 28.7%, 0.685 [0.524–0.895]; brisk walking: 23.9% vs. 14.4%, 0.639 [0.454–0.899]; light- and moderate-intensity PA: 15.4% vs. 8.4%, 0.613 [0.404–0.929]; vigorous-intensity PA: 21.4% vs. 16.8%, 0.715 [0.518–0.989]). They were less likely to spend a sufficient duration in brisk walking (25.9% vs. 16.5%, 0.635 [0.461–0.875]), light- and moderate-intensity PA (37.1% vs. 26.8%, 0.684 [0.521–0.899]), and vigorous-intensity PA (35.3% vs. 35.8%, 0.741 [0.568–0.968]). Compared with MT women, ET women were less likely to be engaged in strolling (30.5% vs. 22.2%, 0.629 [0.398–0.995]), and less likely to spend a sufficient duration in light- and moderate-intensity PA (27.3% vs. 15.3%, 0.561 [0.335–0.937]). Conclusions: ET was inversely associated with LTPA in men and partly in women.

    DOI: 10.1186/s13690-024-01440-z

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  3. Association between milk consumption in middle age and frailty in later life: The Aichi Workers' cohort study Open Access

    Hong, YJ; Otsuka, R; Song, Z; Fukuda, C; Tajima, R; Lin, JY; Hibino, M; Kobayashi, M; He, YP; Matsunaga, M; Ota, A; Nakano, Y; Li, YY; Tamakoshi, K; Yatsuya, H

    GERIATRICS & GERONTOLOGY INTERNATIONAL   24 巻 ( 7 ) 頁: 700 - 705   2024年7月

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    記述言語:英語   出版者・発行元:Geriatrics and Gerontology International  

    Aim: Several studies have shown that dairy consumption in old age is effective in preventing frailty. However, there is a lack of evidence regarding the association between milk consumption during middle age and the development of frailty in old age. Therefore, we carried out an investigation to explore the association between milk consumption during middle age and development of frailty examined after over 15 years of follow up in a long-term cohort study in Japan. Methods: We studied 265 participants aged 60–79 years (212 men and 53 women) in 2018, who participated in both the baseline survey in 2002 and the frailty assessment in 2018. The amount of milk consumption (g/day) at baseline was age- and energy-adjusted, and classified into three categories (no, low and high consumption: 0 g/day, ≤135.86 g/day, >135.86 g/day in men and 0 g/day, ≤126.44 g/day, >126.44 g/day in women). Odds ratios (OR) and 95% confidence intervals (CI) for prefrailty/frailty after adjusting for lifestyles at baseline, stratified by sex, were estimated using logistic regression analysis. Results: The prevalence of prefrailty/frailty in 2018 was 37.7% and 28.3% in men and women, respectively. Milk consumption categories were inversely associated with the prevalence of prefrailty/frailty in men (OR 0.34, 95% CI 0.14–0.84 in low consumption; OR 0.31, 95% CI 0.10–0.95 in high consumption; P < 0.05), but not in women (OR 0.53, 95% CI 0.11–2.65; P = 0.44). Conclusions: In this study, milk intake in middle-aged men was inversely associated with the prevalence of prefrailty/frailty later in life. Geriatr Gerontol Int 2024; 24: 700–705.

    DOI: 10.1111/ggi.14916

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  4. Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers' cohort study Open Access

    Al-shoaibi, AAA; Li, YY; Chiang, CF; Nakano, Y; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Yatsuya, H

    OBESITY RESEARCH & CLINICAL PRACTICE   18 巻 ( 2 ) 頁: 101 - 108   2024年3月

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    記述言語:英語   出版者・発行元:Obesity Research and Clinical Practice  

    Background: The association between obesity and cardiovascular disease (CVD) remains unclear, particularly for those with established CVD risk factors. We analyzed follow-up data from the Aichi Workers’ Cohort Study. We studied the association between the degree of obesity and risk of CVD and its subtypes specifically among individuals with hypertension, hyper-low-density lipoprotein (LDL)-cholesterolemia, or diabetes. Methods: Pooled data of 8972 adults (7076 men and 1896 women) who were recruited between 2002 and 2008 were used in the current analysis. We used multivariable Cox proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between the degree of obesity assessed with body mass index (BMI) and the risk of CVD and its subtypes, i.e., coronary heart disease (CHD) and stroke. Results: During a median of 12 years, there were 197 CVDs (80 CHDs and 117 strokes). BMI ≥ 27.5 compared to 21.0–22.9 kg/m2 was positively and significantly associated with the risks of CVD, CHD, and total stroke. Hypertension, hyper-LDL-cholesterolemia, and diabetes mediated 15.9%, 5.8%, and 8.7% of obesity-CVD associations, respectively, and 28.3% by their combination. In the stratified analyses by the presence of risk factors, BMI ≥ 25.0 (overweight/obesity) compared to BMI < 25 kg/m2 was associated with a higher risk of CVD in those with and without hypertension, but only with hyper-LDL-cholesterolemia, and without diabetes. Conclusions: Overweight/obesity was associated with the risk of CVD and its subtypes. About 30% of the risk was explained by hypertension, hyper-LDL-cholesterolemia, and diabetes, of which hypertension accounted for approximately the half of the explained risk. However, overweight/obesity increased the risk of CVD even in those without hypertension. These findings highlight the importance of controlling and preventing overweight/obesity regardless of chronic disease status.

    DOI: 10.1016/j.orcp.2024.02.006

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  5. Prevalence, severity, and risk factors of cancer-related fatigue among working cancer survivors: a systematic review and meta-analysis

    Matsunaga, M; He, YP; Khine, MT; Shi, XL; Okegawa, R; Li, YY; Yatsuya, H; Ota, A

    JOURNAL OF CANCER SURVIVORSHIP     2024年2月

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    記述言語:英語   出版者・発行元:Journal of Cancer Survivorship  

    Purpose: The aim of this study is to evaluate the prevalence, severity, and risk factors of cancer-related fatigue among currently working cancer survivors. Methods: We searched the PubMed, Embase, Scopus, CINAHL, Cochrane Library, and ICHUSHI databases. The risk of bias was evaluated independently using the Risk of Bias Assessment Tool for Non-randomized Studies (RoBANS). A meta-analysis was conducted to determine the prevalence, severity, and related factors associated with cancer-related fatigue among currently working cancer survivors. Results: Our meta-analysis included 18 studies and revealed that 42.2% of currently working cancer survivors experience cancer-related fatigue. The fatigue severity in this group was significantly higher than that in workers without cancer (absolute standardized mean difference (SMD) = 0.67), but lower than that in cancer survivors who had previously worked and were not currently working (absolute SMD = 0.72). Distress was identified as a potential risk factor for cancer-related fatigue in working cancer survivors (partial correlation coefficient = 0.38). Conclusions: The high prevalence of cancer-related fatigue among employed cancer survivors underscores the need for targeted workplace interventions and fatigue management strategies. While the severity of fatigue is less than that seen in non-working survivors, the comparison with the general working population highlights a significant health disparity. The association between distress and fatigue suggests the necessity for a holistic approach to fatigue management that considers both physical and mental factors in working cancer survivors. Implications for Cancer Survivors: Our findings highlight the critical need for healthcare professionals and employers to monitor fatigue levels among working cancer survivors and offer appropriate support.

    DOI: 10.1007/s11764-024-01557-8

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科研費 3

  1. セレノプロテインPが糖代謝異常に寄与するメカニズムの縦断的な解明

    研究課題/研究課題番号:19K19419  2019年4月 - 2023年3月

    科学研究費助成事業   若手研究

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    担当区分:研究代表者 

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

  2. コロナ禍での持病悪化要因と持病有無が就労関連要因の心血管発症リスクに及ぼす影響

    研究課題/研究課題番号:22H03349  2022年4月 - 2027年3月

    科学研究費助成事業  基盤研究(B)

    八谷 寛, 大塚 礼, 李 媛英, 玉腰 浩司, 太田 充彦, 山田 宏哉, 中野 嘉久, 松永 眞章, 平川 仁尚, 江 啓発

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    担当区分:研究分担者 

    本研究は申請者らが長期間追跡調査を実施している愛知職域コホート研究において、糖尿病や高血圧等の持病の有無により、就労に関わる要因と心血管疾患等発症リスクの関連がどの程度異なるのかを明らかにすること、また追跡調査と生活習慣等の追加調査を同コホート研究で実施し、新型コロナウイルス感染拡大下に、持病を有する労働者の健康状態の悪化が、特にコロナ禍前より把握している職場ストレスなどの就労関連要因により異なるかを検討すること、さらにこれらの目的に即したデータ統合型研究を計画するとともに既存のデータベースを用いた統計解析を行おうとするものである。
    本研究は研究代表者らが長期間追跡調査を実施している愛知職域コホート研究において、糖尿病や高血圧等の持病の有無により、就労に関わる要因と心血管疾患等発症リスクの関連がどの程度異なるのかを明らかにすること、また追跡調査と生活習慣等の追加調査を同コホート研究で実施し、持病を有する労働者の健康状態の悪化が、職場ストレスなどの就労関連要因により異なるかを検討すること、さらにこれらの目的に即したデータ統合型研究を計画するとともに既存のデータベースを用いた統計解析を行おうとするものであり、2022年度には、以下の検討を実施した。
    1.追跡調査の実施:自己申告病歴の詳細に関する診療録情報を医療機関への調査により把握した。
    2.愛知職域コホート研究の第6回繰り返し調査:就労に関わる要因、持病を有する労働者の健康状態の把握に関連する項目を含む生活習慣等アンケート調査を2023年度に実施するための準備を行った。
    3.統計解析:愛知職域コホート研究の第5回までの繰り返し調査、追跡調査結果を用いて、心血管疾患、2型糖尿病、メタボリックシンドロームの発症、さらに退職者の調査結果に基づくフレイルの出現に関する分析等を実施し、論文や学会において発表した。具体的には、LDLコレステロールと心血管疾患発症リスクの関連、縮小ランク回帰によって求めた食事パターンとメタボリックシンドローム発症リスクとの関連、収縮期血圧の長期変動と2型糖尿病発症リスクの関連について論文発表を行った。
    当初の計画通り、追跡調査の実施、愛知職域コホート研究の第6回繰り返し調査に相当する生活習慣等アンケート調査の準備を行った。また、これまでの追跡調査結果を用いて、心血管疾患、2型糖尿病、メタボリックシンドロームの発症、さらに退職者の調査結果に基づくフレイルの出現に関する統計解析を実施し得た。
    2023年度には就労に関わる要因、持病を有する労働者の健康状態の把握に関連する項目を含む生活習慣等アンケート調査を実施し、そのデータベース化を行う。また追跡調査を継続する。さらに、他のデータベースとの統合解析のための疾患定義や曝露変数の共通化可能作業を継続して行う。

  3. 女性保育士の腰痛・頸肩腕障害および就労状況・心理社会的要因との関連:縦断研究

    研究課題/研究課題番号:19K10631  2019年4月 - 2023年3月

    科学研究費助成事業  基盤研究(C)

    太田 充彦, 李 媛英, 八谷 寛, 内藤 久雄, 松永 眞章

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    担当区分:研究分担者 

    腰痛・頸肩腕障害といった就労に関連する筋骨格系障害 (work-related musculoskeletal disorders: WMSD)は有病率が高く、予防対策の重要性が高い。保育士はWMSDになる可能性が高い職業である。女性保育士の腰痛・頸肩腕障害の有病率、自然経過、就労状況や心理社会的要因とWMSDの発症・自然経過との関連を推測するための科学的知見は乏しい。本研究は約500人の女性保育士を5年間追跡したデータを用い、女性保育士の腰痛・頸肩腕障害の有病率、自然経過の実態や、困難な就労状況や心理社会的要因の存在が腰痛・頸肩腕障害の発生・遷延を引き起こすかを明らかにする。
    腰痛は保育労働者に多い筋骨格系障害である。本研究は、保育労働者の腰痛に影響を与える仕事に関する心理社会的要因を明らかにすることを目的とした。444人の保育労働者を対象者にして、観察期間1年の前向きコホート研究(追跡研究)を実施した。調査開始時に腰痛があった人のうち、調査開始時に職場における上司・同僚からの支援(ソーシャルサポート)が少ないと回答した人はそうでない人に比べて1年後に腰痛が持続する確率(調整済みオッズ比)が2.43倍高いことが統計学的に明らかになった。職場の人間関係という心理社会的要因が腰痛の持続の原因になることが示された。
    腰痛の原因には身体的要因(肥満、他の整形外科的疾患)だけでなく、心理的な要因もあると考えられてきた。本研究は、職場の上司・同僚の支援という仕事に関する心理社会的要因が腰痛の持続の原因になることを明らかにした。腰痛の有病率が高い保育労働者における腰痛予防のため、職場の人間関係を良くするという心理社会的要因の改善が効果的である可能性を示すものである。
    本研究では他の仕事に関する心理社会的要因が腰痛の持続におよぼす影響や、仕事に関する心理社会的要因が腰痛の新規発症をもたらす可能性は明らかではなかった。対象者数が少なかったために見いだせなかった可能性などもあるため、さらなる研究が必要である。

 

担当経験のある科目 (本学) 2

  1. 公衆衛生学(医学部修士課程)

    2023

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    日本の医療保障制度と医療費

  2. 公衆衛生学(学部専門科目)

    2023

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    日本の医療保障制度と医療費