Faculty Profiles - MATURANA Andres Daniel

Papers - MATURANA Andres Daniel

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In Silico Binding Mode Analysis of Blarina Paralytic Peptides with the Human T-Type Ca Channel hCav3.2 Invited Reviewed Open Access

Nozomi Hara, Chihiro Sadamoto, Ryo Fukuoka, Yusuke Yano, Andres D Maturana, Masaki Kita

Toxins (Basel) Vol. 17 ( 11 ) page： 549 2025.11

Hyperpolarization Modulation of the T-Type hCav3.2 Channel by Human Synenkephalin [1-53], a Shrew Neurotoxin Analogue without Paralytic Effects Invited Reviewed Open Access

Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kit

Angewandte Chemie International Edition Vol. 64 page： e202503891 2025.7

Effects of aging on calcium channels in skeletal muscle Reviewed Open Access

Mingyi Dong and Maturana Andres

Frontiers in Molecular Biosciences Vol. 12 page： 1558456 2025.3

Glu592 of the axon guidance receptor ROBO3 mediates a pH-dependent interaction with NELL2 ligand Reviewed Open Access

Kimihiko Mizutani , Mayuko Toyoda , Teruyo Ojima-Kato, Andrés D Maturana, Tomoaki Niimi

FEBS Letters Vol. 599 ( 4 ) page： 571 - 580 2025.2

Mammalian neurotoxins, Blarina paralytic peptides, cause hyperpolarization of human T-type Ca channel hCa(v)3.2 activation. Reviewed Open Access

Yano Y, Fukuoka R, Maturana AD, Ohdachi SD, Kita M

The Journal of biological chemistry Vol. 299 ( 9 ) page： 105066 2023.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Biological Chemistry

Among the rare venomous mammals, the short-tailed shrew Blarina brevicauda has been suggested to produce potent neurotoxins in its saliva to effectively capture prey. Several kallikrein-like lethal proteases have been identified, but the active substances of B. brevicauda remained unclear. Here, we report Blarina paralytic peptides (BPPs) 1 and 2 isolated from its submaxillary glands. Synthetic BPP2 showed mealworm paralysis and a hyperpolarization shift (−11 mV) of a human T-type Ca2+ channel (hCav3.2) activation. The amino acid sequences of BPPs were similar to those of synenkephalins, which are precursors of brain opioid peptide hormones that are highly conserved among mammals. However, BPPs rather resembled centipede neurotoxic peptides SLPTXs in terms of disulfide bond connectivity and stereostructure. Our results suggested that the neurotoxin BPPs were the result of convergent evolution as homologs of nontoxic endogenous peptides that are widely conserved in mammals. This finding is of great interest from the viewpoint of the chemical evolution of vertebrate venoms.

DOI： 10.1016/j.jbc.2023.105066

Open Access

Scopus

PubMed

ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma Reviewed International coauthorship Open Access

Mensali Nadia, Koeksal Hakan, Joaquina Sandy, Wernhoff Patrik, Casey Nicholas P., Romecin Paola, Panisello Carla, Rodriguez Rene, Vimeux Lene, Juzeniene Asta, Myhre Marit R., Fane Anne, Ramirez Carolina Castilla, Maggadottir Solrun Melkorka, Duru Adil Doganay, Georgoudaki Anna-Maria, Grad Iwona, Maturana Andres Daniel, Gaudernack Gustav, Kvalheim Gunnar, Carcaboso Angel M., de Alava Enrique, Donnadieu Emmanuel, Bruland Oyvind S., Menendez Pablo, Inderberg Else Marit, Waelchli Sebastien

NATURE COMMUNICATIONS Vol. 14 ( 1 ) page： 3375 2023.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Communications

Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable off-target expression of the potentially targetable proteins. Here we show that chimeric antigen receptor (CAR) T cells could successfully target an isoform of alkaline phosphatase, ALPL-1, which is highly and specifically expressed in primary and metastatic OS. The target recognition element of the second-generation CAR construct is based on two antibodies, previously shown to react against OS. T cells transduced with these CAR constructs mediate efficient and effective cytotoxicity against ALPL-positive cells in in vitro settings and in state-of-the-art in vivo orthotopic models of primary and metastatic OS, without unexpected toxicities against hematopoietic stem cells or healthy tissues. In summary, CAR-T cells targeting ALPL-1 show efficiency and specificity in treating OS in preclinical models, paving the path for clinical translation.

DOI： 10.1038/s41467-023-39097-x

Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding Reviewed Open Access

Miyaguchi Masaki, Nakanishi Yoichi, Maturana Andres D., Mizutani Kimihiko, Niimi Tomoaki

JOURNAL OF MOLECULAR BIOLOGY Vol. 434 ( 19 ) page： 167777 2022.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Molecular Biology

Since neural epidermal growth factor-like-like (NELL) 2 was identified as a novel ligand for the roundabout (Robo) 3 receptor, research on NELL–Robo signaling has become increasingly important. We have previously reported that Robo2 can bind to NELL1/2 in acidic conditions but not at neutral pH. The NELL1/2-binding site that is occluded in neutral conditions is thought to be exposed by a conformational change of the Robo2 ectodomain upon exposure to acidic pH; however, the underlying structural mechanisms are not well understood. Here, we investigated the interaction between the immunoglobulin-like domains and fibronectin type III domains that form hairpin-like structure of the Robo2 ectodomain, and demonstrated that acidic pH attenuates the interaction between them. Alternative splicing isoforms of Robo2, which affect the conformation of the hairpin-like structure, were found to have distinct NELL1/2-binding affinities. We developed Förster resonance energy transfer-based indicators for monitoring conformational change of the Robo2 ectodomain by individually inserting donor and acceptor fluorescent proteins at its ends. These experiments revealed that the ends of the Robo2 ectodomain are close to each other in acidic conditions. By combining these findings with the results of size exclusion chromatography analysis, we suggest that, in acidic conditions, the Robo2 ectodomain has a compact conformation with a loose hairpin-like structure. These results may help elucidate the signaling mechanisms resulting from the interaction between Robo2 and NELL1/2 in acidic conditions.

DOI： 10.1016/j.jmb.2022.167777

Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1 Reviewed International coauthorship Open Access

Tatsuya Hagino, Takafumi Kato, Go Kasuya, Kan Kobayashi, Tsukasa Kusakizako, Shin Hamamoto, Tomoaki Sobajima, Yuichiro Fujiwara, Keitaro Yamashita, Hisashi Kawasaki, Andrés D. Maturana, Tomohiro Nishizawa, Osamu Nureki

Nature Communications Vol. 13 ( 1 ) page： 2505 2022.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

In the light reaction of plant photosynthesis, modulation of electron transport chain reactions is important to maintain the efficiency of photosynthesis under a broad range of light intensities. VCCN1 was recently identified as a voltage-gated chloride channel residing in the thylakoid membrane, where it plays a key role in photoreaction tuning to avoid the generation of reactive oxygen species (ROS). Here, we present the cryo-EM structures of Malus domestica VCCN1 (MdVCCN1) in nanodiscs and detergent at 2.7 Å and 3.0 Å resolutions, respectively, and the structure-based electrophysiological analyses. VCCN1 structurally resembles its animal homolog, bestrophin, a Ca<sup>2+</sup>-gated anion channel. However, unlike bestrophin channels, VCCN1 lacks the Ca<sup>2+</sup>-binding motif but instead contains an N-terminal charged helix that is anchored to the lipid membrane through an additional amphipathic helix. Electrophysiological experiments demonstrate that these structural elements are essential for the channel activity, thus revealing the distinct activation mechanism of VCCN1.

DOI： 10.1038/s41467-022-30292-w

Other Link： https://www.nature.com/articles/s41467-022-30292-w

The structure of MgtE in the absence of magnesium provides new insights into channel gating. Reviewed International coauthorship Open Access

Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M

PLoS biology Vol. 19 ( 4 ) page： e3001231 2021.4

Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression Reviewed International coauthorship Open Access

Ito J, Minemura T, Wälchli S, Niimi T, Fujihara Y, Kuroda S, Takimoto K, Maturana AD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 22 ( 7 ) page： 3561 2021.3

Time-resolved serial femptosecond crystallography reveals early structural changes in channelrhodopsin. Reviewed International coauthorship Open Access

67 Oda K, Nomura T, Nakane T, Yamashita K, Inoue K, Ito S, Vierock J, Hirata K, Maturana AD, Katayama K, Ikuta T, Ishigami I, Izume T, Umeda R, Eguma R, Oishi S, Kasuya G, Kato T, Kusakizako T, Shihoya W, Shimada H, Takatsuji T, Takemoto M, Taniguchi R, Tomita A, Nakamura R, Fukuda M, Miyauchi H, Lee Y, Nango E, Tanaka R, Tanaka T, Sugahara M, Kimura T, Shimamura T, Fujiwara T, Yamanaka Y, Owada S, Joti Y, Tono K, Ishitani R, Hayashi S, Kandori H, Hegemann P, Iwata S, Kubo M, Nishizawa T, Nureki O.

eLife Vol. 10 ( e62389 ) page： 1 - 21 2021.3

アルコール飲料製造における生物学的プロセス

アンドレスマツラナ

アジア遊学 Vol. 250 page： 192 - 205 2020.8

RBM20 Regulates CaV1.2 Surface Expression by Promoting Exon 9*Inclusion of CACNA1C in Neonatal Rat Cardiomyocytes Reviewed Open Access

Morinaga Akihito, Ito Jumpei, Niimi Tomoaki, Maturana Andres D.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 20 ( 22 ) 2019.11

Therapeutic potential for miR-133a/b to prevent Zinc Finger Homeobox 3 loss of function-dependent Atrial Fibrillation Invited Reviewed Open Access

Maturana AD

Acta Physiologica Vol. 227 page： e13322 2019.8

Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2 Reviewed Open Access

Yamamoto Naoka, Kashiwagi Manabu, Ishihara Manami, Kojima Takaaki, Maturana Andres D., Kuroda Shun'ichi, Niimi Tomoaki

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 294 ( 12 ) page： 4693-4703 2019.3

Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter Open Access

Kusakizako Tsukasa, Claxton Derek P., Tanaka Yoshiki, Maturana Andre S. D., Kuroda Teruo, Ishitani Ryuichiro, Mchaourab Hassane S., Nureki Osamu

STRUCTURE Vol. 27 ( 2 ) page： 293 - + 2019.2

MicroRNA-204 Is Necessary for Aldosterone-Stimulated T-Type Calcium Channel Expression in Cardiomyocytes Reviewed International coauthorship Open Access

Koyama Riko, Mannic Tiphaine, Ito Jumpei, Amar Laurence, Zennaro Maria-Christina, Rossier Michel Florian, Maturana Andres Daniel

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 19 ( 10 ) 2018.10

Functional roles of Mg binding sites in ion-dependent gating of a Mg2+ channel Mg2+, revealed by solution NMR Open Access

Maruyama Tatsuro, Imai Shunsuke, Kusakizako Tsukasa, Hattori Motoyuki, Ishitani Ryuichiro, Nureki Osamu, Ito Koichi, Maturana Andres D., Shimada Ichio, Osawa Masanori

ELIFE Vol. 7 2018.4

Electrophysiological analysis of ion channels Invited

Maturana Andres Daniel

Journal of Clinical and Experimental Medicine Vol. 262 ( 5 ) page： 506-514 2017.7

Evidence of involvement of neurone-glia/neurone-neurone communications via gap junctions in synchronised activity of KNDy neurones Reviewed

Ikegami K., Minabe S., Ieda N., Goto T., Sugimoto A., Nakamura S., Inoue N., Oishi S., Maturana A. D., Sanbo M., Hirabayashi M., Maeda K-I, Tsukamura H., Uenoyama Y.

JOURNAL OF NEUROENDOCRINOLOGY Vol. 29 ( 6 ) 2017.6

Crystal structures of the TRIC trimeric intracellular cation channel orthologues. Reviewed Open Access

Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O.

Cell Research Vol. 26 ( 12 ) page： 1288-1301 2016.12

RBM20 and RBM24 cooperatively promote the expression of short enh splice variants. Reviewed

Ito J, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana AD.

FEBS Lett. Vol. 590 ( 4 ) page： 2262-74 2016.7

Bio-nanocapsule-based scaffold improves the sensitivity and ligand-binding capacity of mammalian receptors on the sensor chip. Reviewed

Iijima M, Yoshimoto N, Niimi T, Maturana AD, Kuroda S.

Biotechnol J. Vol. 11 ( 6 ) page： 805-13 2016.6

Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2. Reviewed

Nakatani M, Ito J, Koyama R, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana AD.

Vol. 474 ( 2 ) page： 413-20 2016.5

Mapping the heparin-binding site of the osteoinductive protein NELL1 by site-directed mutagenesis. Reviewed

Takahashi K, Imai A, Iijima M, Yoshimoto N, Maturana AD, Kuroda S, Niimi T.

FEBS Lett. Vol. 589 ( 24 ) page： 4026-32 2015.12

CD14 as a mediator of the mineralocorticoid receptor-dependent anti-apolipoproteinA-1 IgG positive chronotropic effect on cardiomyocytes. Reviewed

52 Mannic T., Satta N., Pagno S., Python M., Mouffok M., Virzi J., Montecucco F., Frias M., Dick J., Maturana A.D., Rossier M.F.,Vuilleumier N.

Endocrinology Vol. 156 ( 12 ) page： 4707-4719 2015.12

Scaffold protein enigma homolog activates CREB whereas a short splice variant prevents CREB activation in cardiomyocytes. Reviewed

Ito J, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana AD.

Cellular Signalling Vol. 27 ( 12 ) page： 2425-2433 2015.9

Intracellular trafficking of bio-nanocapsule-liposome complex: Identification of fusogenic activity in the pre-S1 region of hepatitis B virus surface antigen L protein. Reviewed

Somiya M, Sasaki Y, Matsuzaki T, Liu Q, Iijima M, Yoshimoto N, Niimi T, Maturana AD, Kuroda S.

Journal of Controlled Release Vol. 212 page： 10-18 2015.8

One-step scalable preparation method for non-cationic liposomes with high siRNA content. Reviewed

Somiya M, Yamaguchi K, Liu Q, Niimi T, Maturana AD, Iijima M, Yoshimoto N, Kuroda S.

International Journal of Pharmaceutics Vol. 490 ( 1-2 ) page： 316-323 2015.7

Molecular Dynamics of Channelrhodopsin at the Early Stages of Channel Opening. Reviewed Open Access

Takemoto M, Kato HE, Koyama M, Ito J, Kamiya M, Hayashi S, Maturana AD, Deisseroth K, Ishitani R, Nureki O.

PloS One Vol. 10 ( 6 ) page： e0131094 2015.6

Virosomes of hepatitis B virus envelope L proteins containing doxorubicin: synergistic enhancement of human liver-specific antitumor growth activity by radiotherapy. Reviewed Open Access

Liu Q, Jung J, Somiya M, Iijima M, Yoshimoto N, Niimi T, Maturana AD, Shin SH, Jeong SY, Choi EK, Kuroda S.

International Journal of Nanomedicine Vol. 10 page： 4159-4172 2015.6

Atomistic design of microbial opsin-based blue-shifted optogenetics tools. Reviewed Open Access

Kato HE, Kamiya M, Sugo S, Ito J, Taniguchi R, Orito A, Hirata K, Inutsuka A, Yamanaka A, Maturana AD, Ishitani R, Sudo Y, Hayashi S, Nureki O.

Nature Communications Vol. 6 page： 7177 2015.5

Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK. Reviewed Open Access

Fukuda M, Takeda H, Kato HE, Doki S, Ito K, Maturana AD, Ishitani R, Nureki O.

Nature Communications Vol. 6 page： 7097 2015.5

Structural basis for Na(+) transport mechanism by a light-driven Na(+) pump. Reviewed

Kato HE, Inoue K, Abe-Yoshizumi R, Kato Y, Ono H, Konno M, Hososhima S, Ishizuka T, Hoque MR, Kunitomo H, Ito J, Yoshizawa S, Yamashita K, Takemoto M, Nishizawa T, Taniguchi R, Kogure K, Maturana AD, Iino Y, Yawo H, Ishitani R, Kandori H, Nureki O.

Nature Vol. 521 ( 7550 ) page： 48-53 2015.5

Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg(2+) channel MgtE. Reviewed

Takeda H, Hattori M, Nishizawa T, Yamashita K, Shah ST, Caffrey M, Maturana AD, Ishitani R, Nureki O.

Nature Communications Vol. 5 page： 5374 2014.11

Steroid hormones' genomic and non-genomic actions on cardiac voltage-gated calcium channels.

Ito J, Maturana AD

Nihon Yakurigaku Zasshi Vol. 144 ( 5 ) page： 206-210 2014.11

Exciton circular dichroism in channelrhodopsin. Reviewed

Pescitelli G, Kato HE, Oishi S, Ito J, Maturana AD, Nureki O, Woody RW.

J Phys Chem B. Vol. 118 ( 41 ) page： 11873-11885 2014.10

Structural basis of Sec-independent membrane protein insertion by YidC. Reviewed

Kumazaki K, Chiba S, Takemoto M, Furukawa A, Nishiyama K, Sugano Y, Mori T, Dohmae N, Hirata K, Nakada-Nakura Y, Maturana AD, Tanaka Y, Mori H, Sugita Y, Arisaka F, Ito K, Ishitani R, Tsukazaki T, Nureki O.

Nature Vol. 509 ( 7501 ) page： 516-520 2014.5

Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading. Reviewed

Nakamura Y, Hasebe A, Takahashi K, Iijima M, Yoshimoto N, Maturana AD, Ting K, Kuroda S, Niimi T.

J Biol Chem. Vol. 289 ( 14 ) page： 9781-9794 2014.4

High-throughput de novo screening of receptor agonists with an automated single-cell analysis and isolation system. Reviewed Open Access

Yoshimoto N, Tatematsu K, Iijima M, Niimi T, Maturana AD, Fujii I, Kondo A, Tanizawa K, Kuroda S.

Sci Rep. Vol. 4 page： 4242 2014.2

Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger. Reviewed

Nishizawa T, Kita S, Maturana AD, Furuya N, Hirata K, Kasuya G, Ogasawara S, Dohmae N, Iwamoto T, Ishitani R, Nureki O.

Science Vol. 341 ( 6142 ) page： 168-172 2013.7

Nanocapsule-based probe for evaluating the orientation of antibodies immobilized on a solid phase. Reviewed

Iijima M, Yoshimoto N, Niimi T, Maturana AD, Kuroda S.

Analyst Vol. 138 ( 12 ) page： 3470-3477 2013.6

Enigma homolog 1 promotes myogenic gene expression and differentiation of C2C12 cells. Reviewed

Ito J, Takita M, Takimoto K, Maturana AD.

Biochem Biophys Res Commun. Vol. 435 ( 3 ) page： 483-487 2013.6

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Reviewed Open Access

Tanaka Y, Hipolito CJ, Maturana AD, Ito K, Kuroda T, Higuchi T, Katoh T, Kato HE, Hattori M, Kumazaki K, Tsukazaki T, Ishitani R, Suga H, Nureki O.

Nature Vol. 496 ( 7444 ) page： 247-251 2013.4

DHEA Prevents Mineralo- and Glucocorticoid Receptor-Induced Chronotropic and Hypertrophic Actions in Isolated Rat Cardiomyocytes. Reviewed Open Access

Mannic T, Mouffok M, Python M, Yoshida T, Maturana AD, Vuilleumier N, Rossier MF.

Endocrinology Vol. 154 ( 3 ) page： 1271-1281 2013.3

Cell surface-fluorescence immunosorbent assay for real-time detection of hybridomas with efficient antibody secretion at the single-cell level. Reviewed

Kida A, Iijima M, Niimi T, Maturana AD, Yoshimoto N, Kuroda S.

Anal Chem. Vol. 85 ( 3 ) page： 1753-1759 2013.2

An automated system for high-throughput single cell-based breeding. Reviewed Open Access

Yoshimoto N, Kida A, Jie X, Kurokawa M, Iijima M, Niimi T, Maturana AD, Nikaido I, Ueda HR, Tatematsu K, Tanizawa K, Kondo A, Fujii I, Kuroda S.

Scientific Reports Vol. 3 ( 1191 ) page： 1-9 2013.1

Splicing transitions of the anchoring protein ENH during striated muscle development. Reviewed

Ito J, Hashimoto T, Nakamura S, Aita Y, Yamazaki T, Schlegel W, Takimoto K, Maturana AD.

Biochem Biophys Res Commun. Vol. 241 ( 2 ) page： 232-238 2012.5

Antiapolipoprotein A-1 IgG chronotropic effects require nongenomic action of aldosterone on L-type calcium channels. Reviewed

Rossier MF, Pagano S, Python M, Maturana AD, James RW, Mach F, Roux-Lombard P, Vuilleumier N.

Endocrinology Vol. 153 ( 3 ) page： 1269-1278 2012.3

Crystal structure of the channelrhodopsin light-gated cation channel. Reviewed Open Access

Kato HE, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S, Hegemann P, Maturana AD, Ishitani R, Deisseroth K, Nureki O.

Nature Vol. 482 ( 7385 ) page： 369-374 2012.1

Protein kinase D regulates the human cardiac L-type voltage-gated calcium channel through serine 1884. Reviewed

Aita Y, Kurebayashi N, Hirose S, Maturana AD.

FEBS Lett. Vol. 585 ( 24 ) page： 3903-3906 2011.12

Structure and function of a membrane component SecDF that enhances protein export. Reviewed Open Access

Tsukazaki T, Mori H, Echizen Y, Ishitani R, Fukai S, Tanaka T, Perederina A, Vassylyev DG, Kohno T, Maturana AD, Ito K, Nureki O.

Nature Vol. 474 ( 7350 ) page： 235-238 2011.5

LIM domains regulate protein kinase C activity: a novel molecular function. Reviewed

Maturana AD, Nakagawa N, Yoshimoto N, Tatematsu K, Hoshijima M, Tanizawa K, Kuroda S.

Cell Signal. Vol. 23 ( 5 ) page： 928-924 2011.5

Functions of fasciculation and elongation protein zeta-1 (FEZ1) in the brain. Invited Reviewed

Maturana AD, Fujita T, Kuroda S.

ScientificWorldJournal. Vol. 10 page： 1646-1654 2010.8

Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy. Reviewed

Yamazaki T, Wälchli S, Fujita T, Ryser S, Hoshijima M, Schlegel W, Kuroda S, Maturana AD.

Cardiovasc Res. Vol. 86 ( 3 ) page： 374-382 2010.6

Contribution of mineralocorticoid and glucocorticoid receptors to the chronotropic and hypertrophic actions of aldosterone in neonatal rat ventricular myocytes. Reviewed

Rossier MF, Python M, Maturana AD.

Endocrinology Vol. 151 ( 6 ) page： 2777-2787 2010.6

Mg(2+)-dependent gating of bacterial MgtE channel underlies Mg(2+) homeostasis. Reviewed

Hattori M, Iwase N, Furuya N, Tanaka Y, Tsukazaki T, Ishitani R, Maguire ME, Ito K, Maturana A, Nureki O.

EMBO J. Vol. 28 ( 22 ) page： 3608-3612 2009.11

Role of the T-type calcium channel CaV3.2 in the chronotropic action of corticosteroids in isolated rat ventricular myocytes. Reviewed

Maturana A, Lenglet S, Python M, Kuroda S, Rossier MF.

Endocrinology Vol. 150 ( 8 ) page： 3726-3734 2009.8

Corticosteroids and redox potential modulate spontaneous contractions in isolated rat ventricular cardiomyocytes. Reviewed

Rossier MF, Lenglet S, Vetterli L, Python M, Maturana A.

Hypertension Vol. 52 ( 4 ) page： 721-728 2008.10

Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel. Reviewed Open Access

Maturana AD, Wälchli S, Iwata M, Ryser S, Van Lint J, Hoshijima M, Schlegel W, Ikeda Y, Tanizawa K, Kuroda S.

Cardiovasc Res. Vol. 78 ( 3 ) page： 458-465 2008.6

The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking. Reviewed

Wälchli S, Skånland SS, Gregers TF, Lauvrak SU, Torgersen ML, Ying M, Kuroda S, Maturana A, Sandvig K.

Mol Biol Cell. Vol. 19 ( 1 ) page： 95-104 2008.1

Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Reviewed

Fujita T, Maturana AD, Ikuta J, Hamada J, Walchli S, Suzuki T, Sawa H, Wooten MW, Okajima T, Tatematsu K, Tanizawa K, Kuroda S.

Biochem Biophys Res Commun. Vol. 361 ( 3 ) page： 605-610 2007.9

Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility. Reviewed

Vol. 353 ( 1 ) page： 127-132 2007.2

PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists. Reviewed

Iwata M, Maturana A, Hoshijima M, Tatematsu K, Okajima T, Vandenheede JR, Van Lint J, Tanizawa K, Kuroda S.

Biochem Biophys Res Commun. Vol. 327 ( 4 ) page： 1105-1113 2005.2

Molecular function of axonal guidance-related proteins, UNC-76/FEZ1/FEZ2 Invited

Fujita T, Ikuta J, Maturana A, Okajima T, Tatematsu K, Tanizawa K, Kuroda S.

Recent Res. Devel. Biopys. Biochem. Vol. 4 page： 313-320 2004

Interactions between electron and proton currents in excised patches from human eosinophils. Reviewed Open Access

Petheö GL, Maturana A, Spät A, Demaurex N.

J Gen Physiol. Vol. 122 ( 6 ) page： 713-726 2003.12

Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines. Reviewed

Lilla V, Webb G, Rickenbach K, Maturana A, Steiner DF, Halban PA, Irminger JC.

Endocrinology Vol. 144 ( 4 ) page： 1368-1379 2003.4

NOX family NADPH oxidases: do they have built-in proton channels? Invited

Maturana A, Krause KH, Demaurex N.

J Gen Physiol. Vol. 120 ( 6 ) page： 781-786 2002.12

Spontaneous calcium oscillations control c-fos transcription via the serum response element in neuroendocrine cells. Reviewed Open Access

Maturana A, Van Haasteren G, Piuz I, Castelbou C, Demaurex N, Schlegel W.

J Biol Chem. Vol. 277 ( 42 ) page： 39713-39721 2002.10

Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail. Reviewed

Stasia MJ, Lardy B, Maturana A, Rousseau P, Martel C, Bordigoni P, Demaurex N, Morel F.

Biochim Biophys Acta. Vol. 1586 ( 3 ) page： 316-330 2002.4

A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. Reviewed

Bánfi B, Molnár G, Maturana A, Steger K, Hegedûs B, Demaurex N, Krause KH.

J Biol Chem. Vol. 276 ( 40 ) page： 37594-37601 2001.10

Heme histidine ligands within gp91(phox) modulate proton conduction by the phagocyte NADPH oxidase. Reviewed

Vol. 276 ( 32 ) page： 302777-30284 2001.8

A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Reviewed

Bánfi B, Maturana A, Jaconi S, Arnaudeau S, Laforge T, Sinha B, Ligeti E, Demaurex N, Krause KH.

Vol. 287 ( 5450 ) page： 138-142 2000.1

Measurement of perimitochondrial Ca2+ concentration in bovine adrenal glomerulosa cells with aequorin targeted to the outer mitochondrial membrane. Reviewed Open Access

Brandenburger Y, Arrighi JF, Rossier MF, Maturana A, Vallotton MB, Capponi AM.

Biochem J. Vol. 341 ( 3 ) page： 745-753 1999.8

Angiotensin II negatively modulates L-type calcium channels through a pertussis toxin-sensitive G protein in adrenal glomerulosa cells. Reviewed Open Access

Maturana AD, Casal AJ, Demaurex N, Vallotton MB, Capponi AM, Rossier MF.

J Biol Chem. Vol. 274 ( 28 ) page： 19943-19948 1999.7

Angiotensin II type 1 receptor activation modulates L- and T-type calcium channel activity through distinct mechanisms in bovine adrenal glomerulosa cells. Reviewed

Maturana AD, Burnay MM, Capponi AM, Vallotton MB, Rossier MF.

J Recept Signal Transduct Res. Vol. 19 ( 1-4 ) page： 509-520 1999.1

Duality of the voltage-dependent calcium influx in adrenal glomerulosa cells.

Rossier MF, Burnay MM, Maturana A, Capponi AM

Endocr Res. Vol. 24 ( 3-4 ) page： 443-447 1998.8

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