研究者詳細 - MATURANA Andres Daniel

論文 - MATURANA Andres Daniel

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Effects of aging on calcium channels in skeletal muscle 査読有り

Mingyi Dong and Maturana Andres

Frontiers in Molecular Biosciences 12 巻頁： 1558456 2025年3月

Glu592 of the axon guidance receptor ROBO3 mediates a pH-dependent interaction with NELL2 ligand 査読有り

Kimihiko Mizutani , Mayuko Toyoda , Teruyo Ojima-Kato, Andrés D Maturana, Tomoaki Niimi

FEBS Letters 599 巻 ( 4 ) 頁： 571 - 580 2025年2月

Mammalian neurotoxins, Blarina paralytic peptides, cause hyperpolarization of human T-type Ca channel hCa(v)3.2 activation. 査読有り

Yano Y, Fukuoka R, Maturana AD, Ohdachi SD, Kita M

The Journal of biological chemistry 299 巻 ( 9 ) 頁： 105066 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Biological Chemistry

Among the rare venomous mammals, the short-tailed shrew Blarina brevicauda has been suggested to produce potent neurotoxins in its saliva to effectively capture prey. Several kallikrein-like lethal proteases have been identified, but the active substances of B. brevicauda remained unclear. Here, we report Blarina paralytic peptides (BPPs) 1 and 2 isolated from its submaxillary glands. Synthetic BPP2 showed mealworm paralysis and a hyperpolarization shift (−11 mV) of a human T-type Ca2+ channel (hCav3.2) activation. The amino acid sequences of BPPs were similar to those of synenkephalins, which are precursors of brain opioid peptide hormones that are highly conserved among mammals. However, BPPs rather resembled centipede neurotoxic peptides SLPTXs in terms of disulfide bond connectivity and stereostructure. Our results suggested that the neurotoxin BPPs were the result of convergent evolution as homologs of nontoxic endogenous peptides that are widely conserved in mammals. This finding is of great interest from the viewpoint of the chemical evolution of vertebrate venoms.

DOI： 10.1016/j.jbc.2023.105066

Scopus

PubMed

ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma 査読有り国際共著

Mensali Nadia, Koeksal Hakan, Joaquina Sandy, Wernhoff Patrik, Casey Nicholas P., Romecin Paola, Panisello Carla, Rodriguez Rene, Vimeux Lene, Juzeniene Asta, Myhre Marit R., Fane Anne, Ramirez Carolina Castilla, Maggadottir Solrun Melkorka, Duru Adil Doganay, Georgoudaki Anna-Maria, Grad Iwona, Maturana Andres Daniel, Gaudernack Gustav, Kvalheim Gunnar, Carcaboso Angel M., de Alava Enrique, Donnadieu Emmanuel, Bruland Oyvind S., Menendez Pablo, Inderberg Else Marit, Waelchli Sebastien

NATURE COMMUNICATIONS 14 巻 ( 1 ) 頁： 3375 2023年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature Communications

Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable off-target expression of the potentially targetable proteins. Here we show that chimeric antigen receptor (CAR) T cells could successfully target an isoform of alkaline phosphatase, ALPL-1, which is highly and specifically expressed in primary and metastatic OS. The target recognition element of the second-generation CAR construct is based on two antibodies, previously shown to react against OS. T cells transduced with these CAR constructs mediate efficient and effective cytotoxicity against ALPL-positive cells in in vitro settings and in state-of-the-art in vivo orthotopic models of primary and metastatic OS, without unexpected toxicities against hematopoietic stem cells or healthy tissues. In summary, CAR-T cells targeting ALPL-1 show efficiency and specificity in treating OS in preclinical models, paving the path for clinical translation.

DOI： 10.1038/s41467-023-39097-x

Web of Science

Scopus

PubMed

Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding 査読有り

Miyaguchi Masaki, Nakanishi Yoichi, Maturana Andres D., Mizutani Kimihiko, Niimi Tomoaki

JOURNAL OF MOLECULAR BIOLOGY 434 巻 ( 19 ) 頁： 167777 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Molecular Biology

Since neural epidermal growth factor-like-like (NELL) 2 was identified as a novel ligand for the roundabout (Robo) 3 receptor, research on NELL–Robo signaling has become increasingly important. We have previously reported that Robo2 can bind to NELL1/2 in acidic conditions but not at neutral pH. The NELL1/2-binding site that is occluded in neutral conditions is thought to be exposed by a conformational change of the Robo2 ectodomain upon exposure to acidic pH; however, the underlying structural mechanisms are not well understood. Here, we investigated the interaction between the immunoglobulin-like domains and fibronectin type III domains that form hairpin-like structure of the Robo2 ectodomain, and demonstrated that acidic pH attenuates the interaction between them. Alternative splicing isoforms of Robo2, which affect the conformation of the hairpin-like structure, were found to have distinct NELL1/2-binding affinities. We developed Förster resonance energy transfer-based indicators for monitoring conformational change of the Robo2 ectodomain by individually inserting donor and acceptor fluorescent proteins at its ends. These experiments revealed that the ends of the Robo2 ectodomain are close to each other in acidic conditions. By combining these findings with the results of size exclusion chromatography analysis, we suggest that, in acidic conditions, the Robo2 ectodomain has a compact conformation with a loose hairpin-like structure. These results may help elucidate the signaling mechanisms resulting from the interaction between Robo2 and NELL1/2 in acidic conditions.

DOI： 10.1016/j.jmb.2022.167777

Web of Science

Scopus

PubMed

Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1 査読有り国際共著

Hagino Tatsuya, Kato Takafumi, Kasuya Go, Kobayashi Kan, Kusakizako Tsukasa, Hamamoto Shin, Sobajima Tomoaki, Fujiwara Yuichiro, Yamashita Keitaro, Kawasaki Hisashi, Maturana Andres D., Nishizawa Tomohiro, Nureki Osamu

NATURE COMMUNICATIONS 13 巻 ( 1 ) 頁： 2505 2022年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature Communications

In the light reaction of plant photosynthesis, modulation of electron transport chain reactions is important to maintain the efficiency of photosynthesis under a broad range of light intensities. VCCN1 was recently identified as a voltage-gated chloride channel residing in the thylakoid membrane, where it plays a key role in photoreaction tuning to avoid the generation of reactive oxygen species (ROS). Here, we present the cryo-EM structures of Malus domestica VCCN1 (MdVCCN1) in nanodiscs and detergent at 2.7 Å and 3.0 Å resolutions, respectively, and the structure-based electrophysiological analyses. VCCN1 structurally resembles its animal homolog, bestrophin, a Ca2+-gated anion channel. However, unlike bestrophin channels, VCCN1 lacks the Ca2+-binding motif but instead contains an N-terminal charged helix that is anchored to the lipid membrane through an additional amphipathic helix. Electrophysiological experiments demonstrate that these structural elements are essential for the channel activity, thus revealing the distinct activation mechanism of VCCN1.

DOI： 10.1038/s41467-022-30292-w

Web of Science

Scopus

PubMed

その他リンク： https://www.nature.com/articles/s41467-022-30292-w

The structure of MgtE in the absence of magnesium provides new insights into channel gating. 査読有り国際共著

Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M

PLoS biology 19 巻 ( 4 ) 頁： e3001231 2021年4月

Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression 査読有り国際共著

Ito J, Minemura T, Wälchli S, Niimi T, Fujihara Y, Kuroda S, Takimoto K, Maturana AD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 巻 ( 7 ) 頁： 3561 2021年3月

Time-resolved serial femptosecond crystallography reveals early structural changes in channelrhodopsin. 査読有り国際共著

67 Oda K, Nomura T, Nakane T, Yamashita K, Inoue K, Ito S, Vierock J, Hirata K, Maturana AD, Katayama K, Ikuta T, Ishigami I, Izume T, Umeda R, Eguma R, Oishi S, Kasuya G, Kato T, Kusakizako T, Shihoya W, Shimada H, Takatsuji T, Takemoto M, Taniguchi R, Tomita A, Nakamura R, Fukuda M, Miyauchi H, Lee Y, Nango E, Tanaka R, Tanaka T, Sugahara M, Kimura T, Shimamura T, Fujiwara T, Yamanaka Y, Owada S, Joti Y, Tono K, Ishitani R, Hayashi S, Kandori H, Hegemann P, Iwata S, Kubo M, Nishizawa T, Nureki O.

eLife 10 巻 ( e62389 ) 頁： 1 - 21 2021年3月

アルコール飲料製造における生物学的プロセス招待有り

アンドレスマツラナ

アジア遊学 250 巻頁： 192 - 205 2020年8月

RBM20 Regulates CaV1.2 Surface Expression by Promoting Exon 9*Inclusion of CACNA1C in Neonatal Rat Cardiomyocytes 査読有り

Morinaga Akihito, Ito Jumpei, Niimi Tomoaki, Maturana Andres D.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 巻 ( 22 ) 2019年11月

Therapeutic potential for miR-133a/b to prevent Zinc Finger Homeobox 3 loss of function-dependent Atrial Fibrillation 招待有り査読有り

Maturana AD

Acta Physiologica 227 巻頁： e13322 2019年8月

Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2 査読有り

Yamamoto Naoka, Kashiwagi Manabu, Ishihara Manami, Kojima Takaaki, Maturana Andres D., Kuroda Shun'ichi, Niimi Tomoaki

JOURNAL OF BIOLOGICAL CHEMISTRY 294 巻 ( 12 ) 頁： 4693-4703 2019年3月

Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter

Kusakizako Tsukasa, Claxton Derek P., Tanaka Yoshiki, Maturana Andre S. D., Kuroda Teruo, Ishitani Ryuichiro, Mchaourab Hassane S., Nureki Osamu

STRUCTURE 27 巻 ( 2 ) 頁： 293 - + 2019年2月

MicroRNA-204 Is Necessary for Aldosterone-Stimulated T-Type Calcium Channel Expression in Cardiomyocytes 査読有り国際共著

Koyama Riko, Mannic Tiphaine, Ito Jumpei, Amar Laurence, Zennaro Maria-Christina, Rossier Michel Florian, Maturana Andres Daniel

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19 巻 ( 10 ) 2018年10月

Functional roles of Mg binding sites in ion-dependent gating of a Mg2+ channel Mg2+, revealed by solution NMR

Maruyama Tatsuro, Imai Shunsuke, Kusakizako Tsukasa, Hattori Motoyuki, Ishitani Ryuichiro, Nureki Osamu, Ito Koichi, Maturana Andres D., Shimada Ichio, Osawa Masanori

ELIFE 7 巻 2018年4月

チャネルの電気生理学解析招待有り

マツラナ　アンドレス　ダニエル

医学のあゆみ 262 巻 ( 5 ) 頁： 506-514 2017年7月

Evidence of involvement of neurone-glia/neurone-neurone communications via gap junctions in synchronised activity of KNDy neurones 査読有り

Ikegami K., Minabe S., Ieda N., Goto T., Sugimoto A., Nakamura S., Inoue N., Oishi S., Maturana A. D., Sanbo M., Hirabayashi M., Maeda K-I, Tsukamura H., Uenoyama Y.

JOURNAL OF NEUROENDOCRINOLOGY 29 巻 ( 6 ) 2017年6月

Crystal structures of the TRIC trimeric intracellular cation channel orthologues. 査読有り

Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O.

Cell Research 26 巻 ( 12 ) 頁： 1288-1301 2016年12月

RBM20 and RBM24 cooperatively promote the expression of short enh splice variants. 査読有り

Ito J, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana AD.

FEBS Lett. 590 巻 ( 4 ) 頁： 2262-74 2016年7月

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