Updated on 2022/03/24

写真a

 
KANEKO Hiroki
 
Organization
Nagoya University Hospital Ophthalmology Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 博士(医学) ( 2008.3   名古屋大学 ) 

Research Interests 5

  1. 緑内障

  2. 慢性炎症

  3. 網膜硝子体

  4. 細胞死

  5. 細胞老化

Research History 6

  1. Nagoya University   Lecturer

    2020.5

  2. 名古屋大学医学部附属病院   眼科   病院講師

    2016.5 - 2020.4

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    Country:Japan

  3. 名古屋大学大学院医学系研究科眼科学助教

    2014.8 - 2016.4

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    Country:Japan

  4. 名古屋大学医学部附属病院眼科助教

    2012.10 - 2014.7

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    Country:Japan

  5. 市立四日市病院眼科

    2011.1 - 2012.9

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    Country:Japan

  6. Research fellow, Department of Ophthalmology & Visual Sciences, University of Kentucky

    2008.4 - 2010.12

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    Country:United States

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2008.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 2002.3

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    Country: Japan

Professional Memberships 6

  1. 日本眼科学会

  2. 日本網膜硝子体学会

  3. 日本眼科手術学会

  4. Association for Research in Vision and Ophthalmology (ARVO)

  5. 日本眼科AI学会

  6. 日本糖尿病眼学会

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Awards 6

  1. 第2回わかもと先進眼科医療研究会金賞

    2012.8   わかもと先進眼科医療研究会  

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    Country:Japan

  2. 名古屋大学医師会研究奨励賞

    2015   名古屋大学医師会  

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    Country:Japan

  3. 日本眼科学会学術奨励賞

    2016.4   日本眼科学会  

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    Country:Japan

  4. JRVS Tano-YIA

    2016.12   Japanese Retinal and Vitreous Society  

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    Award type:International academic award (Japan or overseas)  Country:Japan

  5. 第23回 ROHTO Award

    2018.4   ロート製薬株式会社内 RHOTO Award事務局   難治性網膜疾患への挑戦—外科医としての着眼と生物学的理解—

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

  6. バイエル レチナ・アワード

    2020.3   眼科領域(網膜領域)研究助成プログラム レチナ・アワード事務局   シリコーンオイル関連視力低下(SORVL)の病態解明

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    Award type:Award from publisher, newspaper, foundation, etc. 

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Papers 94

  1. The role of VEGF and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration Reviewed

    Koji M Nishiguchi, Makoto Nakamura, Hiroki Kaneko, Shu Kachi, Hiroko Terasaki

    Investigative Ophthalmology &amp Visual Science   Vol. 49 ( 2 ) page: 781-787   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.07-0715

  2. Identification of photoreceptor precursors in the pars plana during ocular development and after retinal injury Reviewed

    Koji M Nishiguchi, Hiroki Kaneko, Makoto Nakamura, Shu Kachi, Hiroko Terasaki

    Investigative Ophthalmology & Visual Sciences   Vol. 49 ( 1 ) page: 422-428   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

  3. Retardation of photoreceptor degeneration in the detached retina of rd1 mouse

    Hiroki Kaneko, Koji M Nishiguchi, Makoto Nakamura, Shu Kachi, Hiroko Terasaki

    Investigative Ophthalmology & Visual Sciences   Vol. 49 ( 2 ) page: 781-787   2008

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.07-0715

  4. Characteristics of bone marrow-derived microglia in the normal and injured retina Reviewed

    Hiroki Kaneko, Koji M Nishiguchi, Makoto Nakamura, Shu Kachi, Hiroko Terasaki

    Investigative Ophthalmology & Visual Sciences   Vol. 49 ( 9 ) page: 4162-4168   2008

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  5. Generation of immature retinal neurons from proliferating cells in the pars plana after retinal histogenesis in mice with retinal degeneration Reviewed

    Koji M Nishiguchi, Hiroki Kaneko, Makoto Nakamura, Shu Kachi, Hiroko Terasaki

    Molecular vision   Vol. 15   page: 187-199   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

  6. CCR3 is a target for age-related macular degeneration diagnosis and therapy Reviewed

    Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J

    Nature   Vol. 460 ( 7252 ) page: 225-230   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature08151

  7. Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth Reviewed

    Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J

    Nature Medicine   Vol. 15 ( 9 ) page: 1023-1030   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nm.2018

  8. Elevated C-reactive protein levels and ARMS2/HTRA1 gene variants in subjects without age-related macular degeneration Reviewed

    Tetsuhiro R Yasuma, Makoto Nakamura, Koji M Nishiguchi, Masato Kikuchi, Hiroki Kaneko, Toshimitsu Niwa, Nobuyuki Hamajima, Hiroko Terasaki

    Molecular vision   Vol. 16   page: 2923-2930   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

  9. The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization Reviewed

    Keiko Kataoka, Koji M Nishiguchi, Hiroki Kaneko, Nico van Rooijen, Shu Kachi, Hiroko Terasaki

    Investigative ophthalmology & visual science   Vol. 52 ( 3 ) page: 1431-1438   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.10-5798

  10. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration Reviewed

    Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J.

    Nature   Vol. 17 ( 471 ) page: 325   2011.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNA (miRNA)-processing enzyme DICER1 is reduced in the RPE of humans with GA, and that conditional ablation of Dicer1, but not seven other miRNA-processing enzymes, induces RPE degeneration in mice. DICER1 knockdown induces accumulation of Alu RNA in human RPE cells and Alu-like B1 and B2 RNAs in mouse RPE. Alu RNA is increased in the RPE of humans with GA, and this pathogenic RNA induces human RPE cytotoxicity and RPE degeneration in mice. Antisense oligonucleotides targeting Alu/B1/B2 RNAs prevent DICER1 depletion-induced RPE degeneration despite global miRNA downregulation. DICER1 degrades Alu RNA, and this digested Alu RNA cannot induce RPE degeneration in mice. These findings reveal a miRNA-independent cell survival function for DICER1 involving retrotransposon transcript degradation, show that Alu RNA can directly cause human pathology, and identify new targets for a major cause of blindness

    DOI: 10.1038/nature09830

  11. Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3 Reviewed

    Mark E Kleinman, Hiroki Kaneko, Won Gil Cho, Sami Dridi, Benjamin J Fowler, Alexander D Blandford, Romulo JC Albuquerque, Yoshio Hirano, Hiroko Terasaki, Mineo Kondo, Takashi Fujita, Balamurali K Ambati, Valeria Tarallo, Bradley D Gelfand, Sasha Bogdanovich, Judit Z Baffi, Jayakrishna Ambati

    Molecular Therapy   Vol. 20 ( 1 ) page: 101-108   2011.10

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    We showed that naked siRNAs suppress neovascularization in mice not via RNAi but via sequence-independent activation of cell surface Toll-like receptor-3 (TLR3). Here, we demonstrate that noninternalized siRNAs induce retinal degeneration in mice by activating surface TLR3 on retinal pigmented epithelial cells. Cholesterol conjugated siRNAs capable of cell permeation and triggering RNAi also induce the same phenotype. Retinal degeneration was not observed after treatment with siRNAs shorter than 21-nts. Other cytosolic dsRNA sensors are not critical to this response. TLR3 activation triggers caspase-3-mediated apoptotic death of the retinal pigment epithelium (RPE) via nuclear translocation of interferon regulatory factor-3. While this unexpected adverse effect of siRNAs has implications for future clinical trials, these findings also introduce a new preclinical model of geographic atrophy (GA), a late stage of dry AMD that causes blindness in millions worldwide.

    DOI: 10.1038/mt.2011.212

  12. DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Reviewed

    Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J

    Cell   Vol. 149 ( 4 ) page: 847-859   2012.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cell.2012.03.036

  13. Evaluation of extended release brimonidine intravitreal device in normotensive rabbit eyes Reviewed

    Sunil P Deokule, Judit Z Baffi, Hong Guo, Marty Nazzaro, Hiroki Kaneko

    Acta ophthalmologica   Vol. 90 ( 5 ) page: e344-348   2012.6

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  14. DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration Reviewed

    Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J

    Proceedings of the National Academy of Sciences   Vol. 111 ( 45 ) page: 16082-16087   2104

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1403814111

  15. Interleukin-18 induces retinal pigment epithelium degeneration in mice Reviewed

    Ryo Ijima, Hiroki Kaneko, Fuxiang Ye, Yosuke Nagasaka, Kei Takayama, Keiko Kataoka, Shu Kachi, Takeshi Iwase, Hiroko Terasaki

    Investigative Ophthalmology & Visual Science   Vol. 55 ( 10 ) page: 6673-6678   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.14-15367

  16. A long-term follow-up of patients with retinopathy of prematurity treated with photocoagulation and cryotherapy Reviewed

    Sayoko Iwase, Hiroki Kaneko, Chieko Fujioka, Kota Sugimoto, Mineo Kondo, Yoshiko Takai, Shu Kachi, Hiroko Terasaki

    Nagoya journal of medical science   Vol. 76 ( 1-2 ) page: 121-128   2014

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  17. IL18 is not therapeutic for neovascular age-related macular degeneration Reviewed

    Hirano Y, Yasuma T, Mizutani T, Fowler B, Tarallo V, Yasuma R, Kim Y, Carvalho AB, Kerur N, Gelfand B, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nunez G, Ambati B, Hinton D, Nagai H, Haro I, Ambati J

    Nature Medicine   Vol. 20 ( 12 ) page: 1372-1375   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nm.3671

  18. Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration Reviewed

    Hiroki Kaneko, Fuxiang Ye, Ryo Ijima, Shu Kachi, Seiichi Kato, Masatoshi Nagaya, Akiko Higuchi, Hiroko Terasaki

    British Journal of Pharmacology   Vol. 171 ( 15 ) page: 3754-3763   2014.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/bph.12737

  19. Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration Reviewed

    Fuxiang Ye, Hiroki Kaneko, Yosuke Nagasaka, Ryo Ijima, Kae Nakamura, Masatoshi Nagaya, Kei Takayama, Hiroaki Kajiyama, Takeshi Senga, Hiromasa Tanaka, Masaaki Mizuno, Fumitaka Kikkawa, Masaru Hori, Hiroko Terasaki

    Scientific reports   Vol. 5   page: 7705   2015.1

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    DOI: 10.1038/srep07705

  20. 眼科医のための先端医療 137.委縮型加齢黄斑変性の原因解明と治療の可能性 Invited

    兼子 裕規・山下 英俊

    あたらしい眼科   Vol. 29 ( 5 ) page: 61   2012.5

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    Authorship:Lead author   Language:Japanese  

  21. 小切開硝子体手術における術中サンプル収集方法の検討 Reviewed

    黒川 幸延・兼子 裕規・浅見 哲・岩瀬 剛・寺崎 浩子

    あたらしい眼科   Vol. 31 ( 11 ) page: 140-142   2014

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  22. Intra- and Postoperative Monitoring of Autologous Neurosensory Retinal Flap Transplantation for Refractory Macular Hole Associated with High Myopia.

    Takeuchi J, Kataoka K, Shimizu H, Tomita R, Kominami T, Ushida H, Kaneko H, Ito Y, Terasaki H

    Retina (Philadelphia, Pa.)   Vol. 41 ( 5 ) page: 921 - 930   2021.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/IAE.0000000000003000

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  23. Effect of internal limiting membrane peeling on visual field sensitivity in eyes with epiretinal membrane accompanied by glaucoma with hemifield defect and myopia

    Kaneko Hiroki, Hirata Norifumi, Shimizu Hideyuki, Kataoka Keiko, Nonobe Norie, Mokuno Kumiko, Terasaki Hiroko

    JAPANESE JOURNAL OF OPHTHALMOLOGY   Vol. 65 ( 3 ) page: 380 - 387   2021.5

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  24. Author Response to Diagnostic Characteristics of B-Scan Swept-Source Optical Coherence Tomography for Patients With Polypoidal Choroidal Vasculopathy.

    Fujita A, Kataoka K, Takeuchi J, Nakano Y, Horiguchi E, Kaneko H, Ito Y, Terasaki H

    Retina (Philadelphia, Pa.)     2021.3

  25. Optical coherence tomography angiography for the diagnosis of granulomatosis with polyangiitis with serous retinal detachment A case report

    Takashi Noriko, Nakamura Aya, Kataoka Keiko, Usui Yoshihiko, Ito Yasuki, Kaneko Hiroki

    MEDICINE   Vol. 100 ( 7 ) page: e24789   2021.2

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  26. Role of deteriorated bone quality in the development of osteoporosis in pheochromocytoma and paraganglioma.

    Yokomoto-Umakoshi M, Umakoshi H, Sakamoto R, Fukumoto T, Ogata M, Nakano Y, Iwahashi N, Kaneko H, Mizoguchi N, Hattori A, Miyazawa T, Matsuda Y, Kawate H, Ogawa Y, Q-AND-A study group.

    Bone   Vol. 142   page: 115607   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bone.2020.115607

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  27. DIAGNOSTIC CHARACTERISTICS OF POLYPOIDAL CHOROIDAL VASCULOPATHY BASED ON B-SCAN SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND ITS INTERRATER AGREEMENT COMPARED WITH INDOCYANINE GREEN ANGIOGRAPHY

    Fujita Ai, Kataoka Keiko, Takeuchi Jun, Nakano Yuyako, Horiguchi Etsuyo, Kaneko Hiroki, Ito Yasuki, Terasaki Hiroko

    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   Vol. 40 ( 12 ) page: 2296 - 2303   2020.12

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    Language:Japanese  

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  28. Protective Effects and Molecular Signaling of n-3 Fatty Acids on Oxidative Stress and Inflammation in Retinal Diseases Reviewed

    Suzumura A, Terao R, Kaneko H

    Antioxidants (Basel)     2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/antiox9100920

  29. Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular Degeneration

    Shimizu H, Yamada K, Suzumura A, Kataoka K, Takayama K, Sugimoto M, Terasaki H, Kaneko H

    Invest Ophthalmol Vis Sci.   Vol. 61 ( 11 ) page: 21   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.61.11.21.

  30. Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular Degeneration

    Shimizu Hideyuki, Yamada Kazuhisa, Suzumura Ayana, Kataoka Keiko, Takayama Kei, Sugimoto Masataka, Terasaki Hiroko, Kaneko Hiroki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 61 ( 11 ) page: 21   2020.9

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  31. Lipid Signaling in Ocular Neovascularization Reviewed

    Terao R, Kaneko H

    Int J Mol Sci   Vol. 21 ( 13 ) page: 4758   2020.7

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  32. Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities Reviewed

    Yamda K, Kaneko H*, Shimizu H, Suzumura A, Namba R, Takayama K, Ito S, Sugimoto M, Terasaki H

    Transl Vis Sci Technol   Vol. 9 ( 8 ) page: 1   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/tvst.9.8.1.

  33. Association Between Retinal Layer Thickness and Perfusion Status in Extramacular Areas in Diabetic Retinopathy.

    Ito H, Ito Y, Kataoka K, Ueno S, Takeuchi J, Nakano Y, Fujita A, Horiguchi E, Kaneko H, Iwase T, Terasaki H

    American journal of ophthalmology   Vol. 215   page: 25-36   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajo.2020.03.019

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  34. Lipid Signaling in Ocular Neovascularization

    Terao Ryo, Kaneko Hiroki

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 13 )   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms21134758

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  35. Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities

    Yamada Kazuhisa, Kaneko Hiroki, Shimizu Hideyuki, Suzumura Ayana, Namba Rina, Takayama Kei, Ito Seina, Sugimoto Masataka, Terasaki Hiroko

    TRANSLATIONAL VISION SCIENCE & TECHNOLOGY   Vol. 9 ( 8 ) page: 1   2020.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/tvst.9.8.1

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  36. Omega-3 Fatty Acid and its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Müller BDNF in Diabetic Retinopathy Reviewed

    Suzumura Ayana, Kaneko Hiroki, Funahashi Yasuhito, Takayama Kei, Nagaya Masatoshi, Ito Seina, Okuno Toshiaki, Hirakata Toshiaki, Nonobe Norie, Kataoka Keiko, Shimizu Hideyuki, Namba Rina, Yamada Kazuhisa, Ye Fuxiang, Ozawa Yoko, Yokomizo Takehiko, Terasaki Hiroko

    DIABETES   Vol. 69 ( 4 ) page: 724-735   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/db19-0550

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  37. Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration

    Matsuura Toshiyuki, Kaneko Hiroki, Takayama Kei, Shibata Rei, Kataoka Keiko, Ito Seina, Tsunekawa Taichi, Shimizu Hideyuki, Suzumura Ayana, Namba Rina, Ito Yasuki, Murohara Toyoaki, Terasaki Hiroko

    BMC OPHTHALMOLOGY   Vol. 20 ( 1 ) page: 56   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12886-020-01334-y

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  38. DIAGNOSTIC CHARACTERISTICS OF POLYPOIDAL CHOROIDAL VASCULOPATHY BASED ON B-SCAN SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND ITS INTERRATER AGREEMENT COMPARED WITH INDOCYANINE GREEN ANGIOGRAPHY.

    Fujita A, Kataoka K, Takeuchi J, Nakano Y, Horiguchi E, Kaneko H, Ito Y, Terasaki H

    Retina (Philadelphia, Pa.)     2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/IAE.0000000000002760

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  39. Japan-Retinal Detachment Registry Report I: preoperative findings in eyes with primary retinal detachment

    Sakamoto Taiji, Kawano Sumihiro, Kawasaki Ryo, Hirakata Akito, Yamashita Hidetoshi, Yamamoto Shuichi, Ishibashi Tatsuro, Yamamoto Shuichi, Baba Takayuki, Sato Eiju, Kitahashi Masayasu, Tatsumi Tomoaki, Miura Gen, Niizawa Tomohiro, Sakamoto Taiji, Yamakiri Keita, Yamashita Toshifumi, Otsuka Hiroki, Sameshima Seiji, Yoshinaga Narimasa, Sonoda Shozo, Hirakata Akito, Koto Takashi, Inoue Makoto, Hirota Kazunari, Itoh Yuji, Orihara Tadashi, Emoto Yoshinobu, Sano Masahiko, Takahashi Hiroyuki, Tokizawa Ryo, Yamashita Hidetoshi, Nishitsuka Koichi, Kaneko Yutaka, Nishi Katsuhiro, Yoshida Akitoshi, Ono Shinji, Hirokawa Hiroyuki, Sogawa Kenji, Omae Tsuneaki, Ishibazawa Akihiro, Kishi Shoji, Akiyama Hideo, Matsumoto Hidetaka, Mukai Ryo, Morimoto Masahiro, Nakazawa Mitsuru, Suzuki Yukihiko, Kudo Takashi, Adachi Kobu, Ishida Susumu, Noda Kousuke, Kase Satoru, Mori Syouhei, Ando Ryo, Saito Michiyuki, Suzuki Tomohiro, Takahashi Kanji, Nagai Yoshimi, Nakauchi Tadashi, Yamada Haruiko, Kusaka Shuji, Tsujioka Daishi, Tsujikawa Akitaka, Suzuma Kiyoshi, Ishibashi Tatsuro, Sonoda Koh-Hei, Ikeda Yasuhiro, Kohno Riichiro, Ishikawa Keijiro, Kondo Mineo, Kozawa Maki, Kitaoka Takashi, Tsuiki Eiko, Ogura Yuichiro, Yoshida Munenori, Morita Hiroshi, Kato Aki, Hirano Yoshio, Sugitani Kazuhiko, Terasaki Hiroko, Iwase Takeshi, Ito Yasuki, Ueno Shinji, Kaneko Hiroki, Nonobe Norie, Kominami Taro, Azuma Noriyuki, Yokoi Tadashi, Shimada Hiroyuki, Nakashizuka Hiroyuki, Hattori Takayuki, Shinojima Ari, Kutagawa Yorihisa, Shiraga Fumio, Morizane Yuki, Kimura Shuhei, Ikeda Tsunehiko, Kida Teruyo, Sato Takaki, Fukumoto Masanori, Emi Kazuyuki, Nakashima Hiroshi, Ohji Masahito, Kakinoki Masashi, Sawada Osamu, Takeuchi Shinobu, Tanaka Sumiyoshi, Iida Tomohiro, Koizumi Hideki, Maruko Ichiro, Hasegawa Taiji, Kogure Akiko, Iijima Hiroyuki, Oshiro Tomohiro, Tateno Yasushi, Kikushima Wataru, Sugiyama Atsushi, Yoneyama Seigo, Kadonosono Kazuaki, Sato Shimpei, Yamane Shin

    JAPANESE JOURNAL OF OPHTHALMOLOGY   Vol. 64 ( 1 ) page: 1 - 12   2020.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10384-019-00702-6

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  40. Caharacteristics and classification of type 3 neovascularization with B-scan flow overlat and en face flow images of optical coherence tomography. Reviewed

    61. Kataoka K, Takeuchi J, Nakano Y, Fujita A, Kaneko H, Ito Y, Terasaki H.

    Retina   Vol. 39 ( 12 ) page: 2332-2340   2019.12

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  41. In Vitro Epiretinal Membrane Model and Antibody Permeability: Relationship With Anti-VEGF Resistance in Diabetic Macular Edema

    Namba Rina, Kaneko Hiroki, Suzumura Ayana, Shimizu Hideyuki, Kataoka Keiko, Takayama Kei, Yamada Kazuhisa, Funahashi Yasuhito, Ito Seina, Nonobe Norie, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 60 ( 8 ) page: 2942 - 2949   2019.7

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    DOI: 10.1167/iovs.19-26788

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  42. Vascular maturity of type 1 and type 2 choroidal neovascularization evaluated by optical coherence tomography angiography

    Nakano Yuyako, Kataoka Keiko, Takeuchi Jun, Fujita Ai, Kaneko Hiroki, Shimizu Hideyuki, Ito Yasuki, Terasaki Hiroko

    PLOS ONE   Vol. 14 ( 4 ) page: e0216304   2019.4

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    DOI: 10.1371/journal.pone.0216304

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  43. Silicone oil-associated retinal light exposure under a surgical microscope.

    Yamada K, Kaneko H, Tsunekawa T, Shimizu H, Suzumura A, Namba R, Takeuchi J, Kataoka K, Takayama K, Inoue M, Ito Y, Terasaki H

    Acta ophthalmologica     2019.1

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    DOI: 10.1111/aos.14038

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  44. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL AVASCULAR ZONE IN CHILDREN WITH A HISTORY OF TREATMENT-REQUIRING RETINOPATHY OF PREMATURITY.

    Nonobe N, Kaneko H, Ito Y, Takayama K, Kataoka K, Tsunekawa T, Matsuura T, Suzumura A, Shimizu H, Terasaki H

    Retina (Philadelphia, Pa.)   Vol. 39 ( 1 ) page: 111-117   2019.1

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    DOI: 10.1097/IAE.0000000000001937

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  45. Biological Characteristics of Subsilicone Oil Fluid and Differences With Other Ocular Humors.

    Shimizu H, Kaneko H, Suzumura A, Takayama K, Namba R, Funahashi Y, Kataoka K, Iwase T, Hwang SJ, Ito S, Yamada K, Ueno S, Ito Y, Terasaki H

    Translational vision science & technology   Vol. 8 ( 1 ) page: 28   2019.1

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    DOI: 10.1167/tvst.8.1.28

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  46. RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes. Reviewed

    Invest Ophthalmol Vis Sci.   Vol. 59 ( 15 ) page: 5795-5802   2018.12

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  47. Novel Classification of Early-stage Systemic Hypertensive Changes in Human Retina Based on OCTA Measurement of Choriocapillaris

    Takayama Kei, Kaneko Hiroki, Ito Yasuki, Kataoka Keiko, Iwase Takeshi, Yasuma Tetsuhiro, Matsuura Toshiyuki, Tsunekawa Taichi, Shimizu Hideyuki, Suzumura Ayana, Ra Eimei, Akahori Tomohiko, Terasaki Hiroko

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 15163   2018.10

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    DOI: 10.1038/s41598-018-33580-y

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  48. CHARACTERISTICS AND CLASSIFICATION OF TYPE 3 NEOVASCULARIZATION WITH B-SCAN FLOW OVERLAY AND EN FACE FLOW IMAGES OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

    Kataoka K, Takeuchi J, Nakano Y, Fujita A, Kaneko H, Ito Y, Terasaki H

    Retina (Philadelphia, Pa.)     2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/IAE.0000000000002357

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  49. INNER MACULAR CHANGES AFTER VITRECTOMY WITH INTERNAL LIMITING MEMBRANE PEELING FOR RHEGMATOGENOUS RETINAL DETACHMENT: Similarity With Alport Syndrome.

    Fukukita H, Ito Y, Iwase T, Kaneko H, Yasuda S, Kataoka K, Terasaki H

    Retina (Philadelphia, Pa.)     2018.9

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    DOI: 10.1097/IAE.0000000000002310

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  50. Optical coherence tomography angiography of choriocapillaris: normative macular choriocapillaris vasculature and novel classification of early-stage systemic hypertensive changes: A cross-sectional study

    Takayama Kei, Ito Yasuki, Kaneko Hiroki, Kataoka Keiko, Iwase Takeshi, Tsunekawa Taichi, Shimizu Hideyuki, Suzumura Ayana, Akahori Tomohiko, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 59 ( 9 ) page: .   2018.7

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  51. Macular Changes in eyes with Alport Syndrome

    Ito Yasuki, Fukukita Hiroshi, Kataoka Keiko, Kaneko Hiroki, Takeuchi Jun, Ito Hirotaka, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 59 ( 9 ) page: .   2018.7

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  52. Caveolin-1 downregulates glial fibrillary acidic protein and vimentin expression of mouse retina and cultured human Muller cell in pathology of proliferative vitreoretinopathy

    Nagasaka Yosuke, Kaneko Hiroki, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 59 ( 9 ) page: .   2018.7

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  53. Changes in refractive characteristics in Japanese children with Down syndrome

    Horio Junna, Kaneko Hiroki, Takayama Kei, Tuzuki Kinichi, Kakihara Hiroko, Iwami Miou, Kawase Yoshikatsu, Tsunekawa Taichi, Yamaguchi Naoko, Nonobe Norie, Terasaki Hiroko

    JAPANESE JOURNAL OF OPHTHALMOLOGY   Vol. 62 ( 2 ) page: 231-236   2018.3

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    DOI: 10.1007/s10384-018-0565-x

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  54. Optical Coherence Tomography Angiography to Quantify Choroidal Neovascularization in Response to Aflibercept Reviewed

    59. Takeuchi J, Kataoka K, Ito Y, Takayama K, Yasuma T, Kaneko H, Terasaki H.

    Ophthalmologica   Vol. 240 ( 2 ) page: 90-98   2018

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  55. Reply.

    Ra E, Ito Y, Kawano K, Iwase T, Kaneko H, Ueno S, Yasuda S, Kataoka K, Terasaki H

    American journal of ophthalmology   Vol. 180   page: 178 - 179   2017.8

  56. Biological Involvement of MicroRNAs in Proliferative Vitreoretinopathy

    Kaneko Hiroki, Terasaki Hiroko

    TRANSLATIONAL VISION SCIENCE & TECHNOLOGY   Vol. 6 ( 4 ) page: 5   2017.7

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    DOI: 10.1167/tvst.6.4.5

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  57. Cytokine profiling in the sub-silicone oil fluid after vitrectomy surgeries for refractory retinal diseases

    Kaneko Hiroki, Takayama Kei, Asami Tetsu, Ito Yasuki, Tsunekawa Taichi, Iwase Takeshi, Funahashi Yasuhito, Ueno Shinji, Nonobe Norie, Yasuda Shunsuke, Suzumura Ayana, Shimizu Hideyuki, Kimoto Reona, Hwang Shiang-Jyi, Terasaki Hiroko

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 2640   2017.5

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    DOI: 10.1038/s41598-017-03124-x

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  58. Comparison between 1-year outcomes of aflibercept with and without photodynamic therapy for polypoidal choroidal vasculopathy: Retrospective observation study

    Takayama Kei, Kaneko Hiroki, Kataoka Keiko, Hattori Kyoko, Ra Eimei, Tsunekawa Taichi, Fukukita Hiroshi, Haga Fuminori, Ito Yasuki, Terasaki Hiroko

    PLOS ONE   Vol. 12 ( 5 ) page: e0176100   2017.5

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    DOI: 10.1371/journal.pone.0176100

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  59. Regeneration of Photoreceptor Outer Segments after Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment. Reviewed

    Ra E, Ito Y, Kawano K, Iwase T, Kaneko H, Ueno S, Yasuda S, Kataoka K, Terasaki H.

    Am J Ophthalmol.   Vol. 177   page: 17-26   2017.5

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  60. Changes in Retinal Microcirculation After Intravitreal Ranibizumab Injection in Eyes With Macular Edema Secondary to Branch Retinal Vein Occlusion

    Fukami Marie, Iwase Takeshi, Yamamoto Kentaro, Kaneko Hiroki, Yasuda Shunsuke, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 58 ( 2 ) page: 1246-1255   2017.2

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    DOI: 10.1167/iovs.16-21115

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  61. High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy

    Takayama Kei, Kaneko Hiroki, Kachi Shu, Ra Eimei, Ito Yasuki, Terasaki Hiroko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 1 ) page: 103-108   2017.2

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    DOI: 10.18999/nagjms.79.1.103

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  62. Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy Reviewed

    Nagasaka Y, Kaneko H, Ye F, Kachi S, Asami T, kato S, Takayama K, Hwang SJ, Kataoka K, Shimizu H, Iwase T, Funahashi Y, Higuchi A, Senga T, Terasaki H.

    Invest Ophthalmol Vis Sci.   Vol. 58 ( 1 ) page: 221-229   2017.1

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  63. Better Visual Outcome by Intraocular Lens Ejection in Geriatric Patients with Ruptured Ocular Injuries

    Kaneko Hiroki, Asami Tetsu, Sugita Tadasu, Tsunekawa Taichi, Matsuura Toshiyuki, Takayama Kei, Yamamoto Kentaro, Kachi Shu, Ito Yasuki, Ueno Shinji, Nonobe Norie, Kataoka Keiko, Suzumura Ayana, Iwase Takeshi, Terasaki Hiroko

    PLOS ONE   Vol. 12 ( 1 ) page: e0170094   2017.1

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    DOI: 10.1371/journal.pone.0170094

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  64. Comparison of indocyanine green angiography and optical coherence tomographic angiography in polypoidal choroidal vasculopathy

    Takayama K., Ito Y., Kaneko H., Kataoka K., Sugita T., Maruko R., Hattori K., Ra E., Haga F., Terasaki H.

    EYE   Vol. 31 ( 1 ) page: 45-52   2017.1

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    DOI: 10.1038/eye.2016.232

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  65. Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy

    Nagasaka Yosuke, Kaneko Hiroki, Ye Fuxiang, Kachi Shu, Asami Tetsu, Kato Seiichi, Takayama Kei, Hwang Shiang-Jyi, Kataoka Keiko, Shimizu Hideyuki, Iwase Takeshi, Funahashi Yasuhito, Higuchi Akiko, Senga Takeshi, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 58 ( 1 ) page: 221-229   2017.1

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    DOI: 10.1167/iovs.16-20513

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  66. Increased retinal thinning after combination of internal limiting membrane peeling and silicone oil endotamponade in proliferative diabetic retinopathy Reviewed

    Kaneko H, Matsuura T, Takayama K, Ito Y, Iwase T, Ueno S, Nonobe N, Yasuda S, Kataoka K, Terasaki H.

    Ophthalmologica   Vol. 238 ( 4 ) page: 226-235   2017

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  67. Biological involvement of microRNAs in proliferative vitreoretinopathy Reviewed

    Kaneko H, Terasaki H

    Transl Vis Sci Technol.   Vol. 6 ( 4 ) page: 5   2017

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  68. Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-related Macular Degeneration Reviewed

    44. Matsuura T, Takayama K, Kaneko H*, Ye F, Fukukita H, Tsunekawa T, Kataoka K, Hwang SJ, Nagasaka Y, Ito Y, Terasaki H

    Oxid Med Cell Longev     page: 9548767   2017

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  69. Correlation between miR148 expression in vitreous and severity of rhegmatogenous retinal detachment Reviewed

    45. Tsunekawa T, Kaneko H*, Takayama K, Hwang SJ, Oishi A, Nagasaka Y, Ye F, Iwase T, Nonobe N, Ueno S, Ito Y, Yasuda S, Matsuura T, Shimizu H, Suzumura A, Kataoka K, Terasaki H

    Biomed Res Int.     page: 3427319   2017

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  70. One-Year Outcomes of 1 + pro re nata versus 3 + pro re nata Intravitreal Aflibercept Injection for Neovascular Age-Related Macular Degeneration. Reviewed

    Takayama K, Kaneko H, Sugita T, Maruko R, Hattori K, Ra E, Kawano K, Kataoka K, Ito Y, Terasaki H.

    Ophthalmologica   Vol. 237 ( 2 ) page: 105-110   2017

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  71. One-Year Outcomes of 1+pro re nata versus 3+pro re nata Intravitreal Aflibercept Injection for Neovascular Age-Related Macular Degeneration

    Takayama Kei, Kaneko Hiroki, Sugita Tadasu, Maruko Ruka, Hattori Kyoko, Ra Eimei, Kawano Kenichi, Kataoka Keiko, Ito Yasuki, Terasaki Hiroko

    OPHTHALMOLOGICA   Vol. 237 ( 2 ) page: 105-110   2017

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    DOI: 10.1159/000461785

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  72. Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration

    Matsuura Toshiyuki, Takayama Kei, Kaneko Hiroki, Ye Fuxiang, Fukukita Hiroshi, Tsunekawa Taichi, Kataoka Keiko, Hwang Shiang-Jyi, Nagasaka Yosuke, Ito Yasuki, Terasaki Hiroko

    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY   Vol. 2017   page: 9548767   2017

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    DOI: 10.1155/2017/9548767

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  73. Increased Retinal Thinning after Combination of Internal Limiting Membrane Peeling and Silicone Oil Endotamponade in Proliferative Diabetic Retinopathy

    Kaneko Hiroki, Matsuura Toshiyuki, Takayama Kei, Ito Yasuki, Iwase Takeshi, Ueno Shinji, Nonobe Norie, Yasuda Shunsuke, Kataoka Keiko, Terasaki Hiroko

    OPHTHALMOLOGICA   Vol. 238 ( 4 ) page: 226-235   2017

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    DOI: 10.1159/000479482

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  74. A Case of Immunoglobulin G4-associated Anterior Uveitis and Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome

    Takayama Kei, Kaneko Hiroki, Terasaki Hiroko

    OCULAR IMMUNOLOGY AND INFLAMMATION   Vol. 25 ( 5 ) page: 698 - 699   2017

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    DOI: 10.3109/09273948.2016.1161056

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  75. Association of Intraocular Pressure Changes With Right Ventricular Diameter and Brain Natriuretic Peptide in a Case of Pulmonary Arterial Hypertension. Reviewed

    Sato C, Kaneko H, Kondo T, Takayama K, Yasuda S, Terasaki H

    J Glaucoma   Vol. 25 ( 3 ) page: e295   2016.3

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    DOI: 10.1097/IJG.0000000000000371.

  76. Malondialdehyde induces autophagy dysfunction and VEGF secretion in the retinal pigment epithelium in age-related macular degeneration.

    Ye F, Kaneko H, Hayashi Y, Takayama K, Hwang SJ, Nishizawa Y, Kimoto R, Nagasaka Y, Tsunekawa T, Matsuura T, Yasukawa T, Kondo T, Terasaki H.

    Free Radic Biol Med.   Vol. 94   page: 121   2016.2

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    DOI: 10.1016/j.freeradbiomed.2016.02.027.

  77. Optical coherence tomography angiography in leber hereditary optic neuropathy43. Takayama K, Ito Y, Kaneko H, Kataoka K, Ra E, Terasaki H. Reviewed

    Takayama K, Ito Y, Kaneko H, Kataoka K, Ra E, Terasaki H.

    Acta Ophthalmologica     2016

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    DOI: 10.1111/aos.13244

  78. Nuclear Factor (Erythroid-Derived)-Related Factor 2-Associated Retinal Pigment Epithelial Cell Protection under Blue Light-Induced Oxidative Stress. Reviewed

    Nuclear Factor (Erythroid-Derived)-Related Factor 2-Associated Retinal Pigment Epithelial Cell Protection under Blue Light-Induced Oxidative Stress.

    42. Takayama K, Kaneko H*, Kataoka K, Kimoto R, Hwang SJ, Ye F, Nagasaka Y, Tsunekawa T, Matsuura T, Nonobe N, Ito Y, Terasaki H.     2016

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    DOI: 10.1155/2016/8694641

  79. Development of a Fiber-Optic Optical Coherence Tomography Probe for Intraocular Use. Reviewed

    Asami T, Terasaki H, Ito Y, Sugita T, Kaneko H, Nishiyama J, Namiki H, Kobayashi M, Nishizawa N

    Invest Ophthalmol Vis Sci.   Vol. 57 ( 9 ) page: OCT568   2016

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  80. Cross-sectional pupillographic evaluation of relative afferent pupillary defect in age-related macular degeneration Reviewed

    40. Takayama K, Ito Y, Kaneko H, Nagasaka Y, Tsunekawa T, Sugita T, Terasaki H.

    Medicine (Baltimore).   Vol. 95 ( 39 ) page: e4978   2016

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  81. Short-term focal macular electroretinogram of eyes treated by aflibercept & photodynamic therapy for polypoidal choroidal vasculopathy. Reviewed

        2016

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    DOI: 10.1007/s00417-016-3468-x

  82. Evaluation of Short-Term Outcomes of Intravitreal Aflibercept Injections for Age-Related Macular Degeneration Using Focal Macular Electroretinography Reviewed

    38. Takayama K, Kaneko H, Ueno S, Maruko R, Piao CH, Yasuda S, Kawano K, Ito Y, Terasaki H.

    Retina.     2016

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    DOI: 10.1097/IAE.0000000000001225

  83. Development of a Fiber-Optic Optical Coherence Tomography Probe for Intraocular Use. Reviewed

    37. Asami T, Terasaki H, Ito Y, Sugita T, Kaneko H, Nishiyama J, Namiki H, Kobayashi M, Nishizawa N

    Invest Ophthalmol Vis Sci.   Vol. 27 ( 9 ) page: OCT568   2016

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  84. Pyramidal-Shaped Residual Subretinal Fluid at Fovea After Intravitreal Injection of Perfluoro-n-Octane in Eyes With Fovea-Off Rhegmatogenous Retinal Detachment. Reviewed

    36. Iwase T, Ra E, Asami T, Yamamoto K, Kaneko H, Terasaki H

    Retina.   Vol. 36 ( 11 ) page: e108   2016

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  85. A Case of Immunoglobulin G4-Associated Anterior Uveitis and Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Reviewed

    Takayama K, Kaneko H, Terasaki H

    Ocul Immunol Inflamm   Vol. 18   page: 1-2   2016

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  86. Increased ocular levels of microRNA148a in cases of retinal detachment promote epithelial mesenchymal transition Reviewed

    33. Takayama K, Kaneko H*, Hwang SJ, Ye F, Higuchi A, Tsunekawa T, Matsuura T, Iwase T, Asami T, Ito Y, Ueno S, Yasuda S, Nonobe N, Terasaki H

    Invest Ophthalmol Vis Sci.   Vol. 57 ( 6 ) page: 2699   2016

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  87. Human IgG1 antibodies suppress angiogenesis in a target-independent manner" Signal Transduction and Targeted Therapy Reviewed

    32. Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi J, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler B, Gelfand B, Tudisco L, Cicatiello V, Apicella I, De Falco S, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ogura Y, Kaneko H, Ijima R, Terasaki H, Ambati BK, Leusen J, Langdon W, Clark M, Armour K, Bruhns P, Verbeek J, Wright C, Ambati J

    Signal Transduction and Targeted Therapy   Vol. 1   page: pii: 15001   2016

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    DOI: pii: 15001

  88. Expression of Vascular Endothelial Growth Factor by Retinal Pigment Epithelial Cells Induced by Amyloid Beta is Depressed by an Endoplasmic Reticulum Stress Inhibitor Reviewed

    30. Matsui A, Kaneko H*, Kachi S, Ye F, Hwang SJ, Katayama K, Nagasaka Y, Sugita T, Terasaki H.

    Ophthalmic Res,   Vol. 55   page: 37-44   2016

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  89. Differences of Retinal Blood Flow Between Arteries and Veins Determined by Laser Speckle Flowgraphy in Healthy Subjects. Reviewed

    Iwase T, Ra E, Yamamoto K, Kaneko H, Ito Y, Terasaki H.

    Medicine (Baltimore).   Vol. 94 ( 33 ) page: e1256   2015.8

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    DOI: 10.1097/MD.0000000000001256.

  90. Significant Correlation between Retinal Venous Tortuosity and Aqueous Vascular Endothelial Growth Factor Concentration in Eyes with Central Retinal Vein Occlusion. Reviewed

    Yasuda S, Kachi S, Kondo M, Ueno S, Kaneko H, Terasaki H.

    PLoS One   Vol. 10 ( 7 ) page: e0134267   2015.7

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    DOI: 10.1371/journal.pone.0134267

  91. Sex-Related Differences in Ocular Blood Flow of Healthy Subjects Using Laser Speckle Flowgraphy. Reviewed

    Yanagida K, Iwase T, Yamamoto K, Ra E, Kaneko H, Murotani K, Matsui S, Terasaki H.

    Invest Ophthalmol Vis Sci   Vol. 56 ( 8 ) page: 4880-4980   2015.7

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    DOI: 10.1167/iovs.15-16567

  92. Suppression of Laser-Induced Choroidal Neovascularization by the Oral Medicine Targeting Histamine Receptor H4 in Mice

      Vol. 4 ( 2 ) page: 6   2015.3

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    DOI: 10.1167/tvst.4.2.6

  93. Surgical Videos with Synchronised Vertical 2-Split Screens Recording the Surgeons' Hand Movement. Reviewed

    Kaneko H, Ra E, Kawano K, Yasukawa T, Takayama K, Iwase T, Terasaki H.

    Ophthalmologica.   Vol. 234 ( 4 ) page: 243   2015

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    DOI: 10.1159/000439119

  94. Expression of Vascular Endothelial Growth Factor by Retinal Pigment Epithelial Cells Induced by Amyloid-β Is Depressed by an Endoplasmic Reticulum Stress Inhibitor. Reviewed

    Matsui A, Kaneko H, Kachi S, Ye F, Hwang SJ, Takayama K, Nagasaka Y, Sugita T, Terasaki H.

    Ophthalmic Res.   Vol. 55 ( 1 ) page: 37   2015

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    DOI: 10.1159/000440885.

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Books 12

  1. 血液・造血器疾患による網膜病変

    兼子 裕規( Role: Contributor)

    眼疾患アトラスシリーズ・後眼部アトラス  2019 

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    Language:Japanese Book type:Scholarly book

  2. Age-related macular degeneration In Toyokuni S et al. (ed): Plasma Medical Science

    Hiroki Kaneko, Hiroko Terasaki( Role: Contributor)

    Academic Press, Cambridge  2018 

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    Language:English Book type:Scholarly book

  3. 網膜疾患と血液中マーカー

    兼子 裕規( Role: Contributor)

    Retina Medicine  2018 

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    Language:Japanese Book type:Scholarly book

  4. 貧血網膜症

    兼子 裕規( Role: Contributor)

    眼底疾患パーフェクトアトラス  2017 

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    Language:Japanese Book type:Scholarly book

  5. こんなときどうする 眼外傷<眼球破裂、穿孔性眼外傷>

    兼子 裕規( Role: Contributor)

    OCULISTA  2017 

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    Language:Japanese Book type:Scholarly book

  6. 基礎研究コラム 5.細胞におけるノンコーディングRNAの役割

    兼子 裕規( Role: Contributor)

    あたらしい 眼科  2017 

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    Language:Japanese Book type:Scholarly book

  7. Retina施設めぐり(研究室編)

    兼子 裕規( Role: Contributor)

    Retina Medicine  2017 

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    Language:Japanese Book type:Scholarly book

  8. 眼科疾患とオートファジー

    兼子 裕規( Role: Contributor)

    日本の眼科  2017 

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    Language:Japanese Book type:Scholarly book

  9. 鑑別診断 吉村長久, 寺崎浩子(編): 眼科臨床エキスパート 網膜剥離と極小切開硝子体手術

    兼子 裕規( Role: Contributor)

    医学書院、東京  2015 

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    Language:Japanese Book type:Scholarly book

  10. 脈絡膜新生血管モデル-ターゲット別! 画像診断お助けガイド−基本画像から最新モダリティまで

    兼子 裕規( Role: Contributor)

    臨床眼科  2014 

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    Language:Japanese Book type:Scholarly book

  11. 萎縮型加齢黄斑変性の原因解明と治療の可能性

    兼子 裕規・山下 英俊( Role: Contributor)

    あたらしい 眼科  2012 

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    Language:Japanese Book type:Scholarly book

  12. 未熟児網膜症治療の現状と展望

    寺崎浩子, 高井佳子, 兼子裕規( Role: Contributor)

    現代医学  2006 

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    Language:Japanese Book type:Scholarly book

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Presentations 37

  1. 加齢黄斑変性の新規治療ターゲットとしてのヒスタミンH4受容体:日本眼科学会学術奨励賞記念講演

    兼子裕規

    第120回 日本眼科学会総会 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:仙台  

  2. TLR3 Inhibitors Blocks Double Stranded RNA-Induced Retinal Degeneration International conference

    Kaneko, M.E. Kleinman, W. Cho, J.Z. Baffi, K. Saito, M.G. Rich, R.J.C. Albuquerque, J. Ambati.

    ARVO2009 Annual Meeting 

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    Event date: 2009.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  3. A new therapeutic target in age-related macular degeneration International conference

    Hiroki Kaneko

    Asia-ARVO 2015 

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    Event date: 2015.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Yokohama   Country:Japan  

  4. Biological change in retinal detachment International conference

    Hiroki Kaneko

    Asia-ARVO 2015 

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    Event date: 2015.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Yokohama   Country:Japan  

  5. Histamine receptor H4 as a new therapeutic target for age-related macular degeneration International conference

    Hiroki Kaneko

    13th Congress of the International Ocular Inflammation Society (IOIS) 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Sab Francisco   Country:United States  

  6. Cytokine profiling in the sub-silicone oil fluid after vitrectomy surgeries for refractory retinal diseases International conference

    Hiroki Kaneko, Kei Takayama, Taichi Tsunekawa, Takeshi Iwase, Hiroko Terasaki

    EURETINA Congress 2017 

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Barcelona   Country:Spain  

  7. Possible causes of silicone-oil related vision loss in RD and PVR International conference

    Hiroki Kaneko

    The 12th Asia-Pacific Vitreo-retina Society (APVRS) Congress 

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    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Seoul   Country:Korea, Republic of  

  8. Seasonal variation and gender differences in submacular hemorrhages caused by retinal macroaneurysms and age-related macular degeneration International conference

    Hiroki Kaneko

    The 14th Joint Meeting of Japan-China-Korea Ophthalmologists  2021.11.27 

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    Event date: 2021.11

    Language:English   Presentation type:Poster presentation  

  9. 糖尿病網膜症における神経障害の病態理解とオメガ3脂肪酸内服による治療の可能性 Invited

    兼子 裕規

    第27回日本糖尿病眼学会総会  2021.10.8  日本糖尿病眼学会

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    Event date: 2021.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:大津市  

  10. AMDと炎症 〜腸内細菌は網膜疾患に関係あるのか〜 Invited

    兼子裕規

    第54回日本眼炎症学会 ランチョンセミナー 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:仙台  

  11. 硝子体同時手術におけるIOL選択基準の変遷

    兼子裕規

    第125回日本眼科学会総会 ランチョンセミナー 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  12. シリコーンオイルによる網膜フェロトーシス

    兼子裕規

    第125回日本眼科学会総会 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪  

  13. シリコーンオイルの生理:シンポジウム16「手術から学ぶ網膜生理」

    兼子裕規

    第73回臨床眼科学会 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:京都  

  14. マロンジアルデヒドと加齢黄斑変性 Invited

    兼子裕規

    第39回日本眼薬理学会 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:名古屋  

  15. 加齢黄斑変性のバイオマーカー Invited

    兼子裕規

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    Event date: 2019.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:札幌  

  16. Possible mechanism of silicone-oil related vision loss in intractable retinal diseases International conference

    Hiroki Kaneko

    ARVO Annual Meeting 2019  ARVO

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    Event date: 2019.4 - 2019.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Vancouver  

  17. Possible causes of silicone-oil related vision loss in RD and PVR Invited

    Hiroki Kaneko

    The 12th Asia-Pacific Vitreo-retina Society (APVRS) Congress  Asia-Pacific Vitreo-retina Society

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    Event date: 2018.12

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Seoul  

  18. 免疫・補体経路と網膜疾患”インストラクションコース, 網膜橋渡し研究アップデート

    兼子裕規

    第72回日本臨床眼科学会 

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    Event date: 2018.10 - 2018.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  19. バックリング手術に必要な準備:インストラクションコース, 網膜復位術の基本と極意

    兼子裕規

    第71回日本臨床眼科学会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  20. 酸化ストレスマーカーが示すAMDとサプリメンテーション

    兼子裕規

    第71回日本臨床眼科学会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  21. Dry AMD: Potential Therapeutic Targets

    Hiroki Kaneko

    Asia-Pacific Academy of Ophthalmology Congress  Asia-Pacific Academy of Ophthalmology

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    Event date: 2016.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Taipei  

  22. DICER1減少による萎縮型AMDの分子メカニズム

    兼子裕規

    日本眼科学会総会  日本眼科学会

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    Event date: 2015.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:札幌  

  23. 脂質代謝物マロンジアルデヒドが網膜色素上皮細胞に与える影響

    兼子裕規

    第53回日本網膜硝子体学会 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪  

  24. 都市部の若手~中堅眼科医における水晶体嚢外摘出術に対する実態調査

    兼子裕規,藤岡千重子,杉本浩多,古橋里衣子

    第66回日本臨床眼科学会 

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    Event date: 2012.10

    Language:English   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

    今日の白内障手術は超音波を使用した手術(EPA)が主流である。そのため若手眼科医が前世代の白内障手術術式である水晶体嚢外摘出術(ECCE)を経験する機会が減ってきている。今回東海地方の多くの若手眼科医にアンケートを行い、ECCE術式選択が必要と考えられる症例に直面した際にどのような判断をとるかなど、意見を聴取した。

  25. 骨髄由来細胞のマウス網膜内への生着

    兼子裕規・西口康二・中村誠・加地秀・寺崎浩子

    第46回日本網膜硝子体学会総会 

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    Event date: 2007.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:青森  

  26. 人工的網膜剥離によるrd1マウスの網膜形態保存

    兼子裕規

    第110回日本眼科学会総会 

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    Event date: 2006.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪  

  27. 腸内細菌叢と近視 Invited

    兼子裕規

    第4回近視研究会学術集会  2019.11.9  近視研究会

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京  

  28. 手術と科学で考える網膜診療と緑内障診療のマッチング Vol.2 Invited

    兼子裕規

    第9回西東京Ophthalmic Seminar  2021.9.30 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  29. 網膜硝子体疾患研究の進め方:硝子体サンプルの解析と病態解明 スキルトランスファー

    兼子裕規

    第125回日本眼科学会総会 

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    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:大阪  

  30. 手術と科学で考える網膜診療と緑内障診療のマッチング Invited

    兼子裕規

    第22回沖縄眼研究フロンティア  2021.1.30 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:那覇(Webinar)  

  31. 硝子体術者に相性が良い緑内障デバイスと手術の考え方 Invited

    兼子裕規

    第59回日本網膜硝子体学会総会イブニングセミナー  2020.11.27 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡  

  32. 加齢黄斑変性に対するバイオ医薬と高騰する医療費 Invited

    兼子裕規

    第28群馬眼科フォーラム  2018.11.2 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  33. The relationship between inflammatory cytokines in the sub-silicone oil fluid and retinal thickness in eyes with proliferative vitreoretinopathy and proliferative diabetic retinopathy

    Hiroki Kaneko, Hideyuki Shimizu, Taichi Tsunekawa, Takeshi Iwase, Toshiyuki Matsuura, Ayana Suzumura, Rina Namba, Hiroko Terasaki

    ARVO 2018 Annual Meeting  2018 

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    Language:English   Presentation type:Poster presentation  

    Venue:Honolulu  

  34. ドライAMD診療のアップデート

    兼子裕規

    第5回Tokai Retinea Seminar  2017.5.25 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:名古屋  

  35. RPE of Aged Mice Displays TLR3 Activation and dsRNA Binding Protein Reduction International conference

    Hiroki Kaneko

    ARVO 2010 Annual Meeting  2010.5 

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    Presentation type:Poster presentation  

  36. Anti-histamine receptor 4 therapy inhibits choroidal neovascularization in mice International conference

    Hiroki Kaneko

    ARVO 2013 Annual Meeting  2013.5 

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    Language:English   Presentation type:Poster presentation  

    Venue:Seattle   Country:United States  

  37. 田舎町 Kentucky 留学体験記 Invited

    兼子裕規

    Alcon Novartis Hida Memorial Award 2014 授賞セミナー  2014 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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Research Project for Joint Research, Competitive Funding, etc. 14

  1. 網膜色素上皮の細胞老化と加齢黄斑変性

    2019 - 2020

    参天製薬創業者記念眼科医学研究基金 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000

  2. 目指せ“失明患者ゼロ”加齢黄斑変性の新たな敵:網膜下線維性増殖

    2018.11 - 2020.10

    武田科学振興財団ビジョナリーリサーチ(スタート) 

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    Grant type:Competitive

  3. 網膜剥離眼に発生する特異的microRNAの発現レベルと網膜剥離術後予後との関連

    2016.9 - 2017.8

    三島済一記念眼科研究国際交流基金国内研究助成 

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    Grant type:Competitive

  4. 網膜剥離の重症化とmicroRNAの関与 に関する研究

    2016.4 - 2017.3

    伊藤忠兵衛基金研究助成 

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    Grant type:Competitive

  5. 不飽和脂肪酸摂取が加齢黄斑変性に与える影響

    2016.2 - 2018.1

    難病医学研究財団医学研究症例助成 

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    Grant type:Competitive

  6. 黄斑機能障害における機能温存のための研究

    2016 - 2017

    公益財団法人堀科学芸術振興財団  公益財団法人堀科学芸術振興財団 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000

  7. 糖尿病網膜症早期の慢性炎症による細胞傷害の解明

    2015.1 - 2015.12

    上原記念生命学術財団研究助成 

    兼子裕規

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    Grant type:Competitive

  8. Caveolin-1による増殖硝子体網膜症の発症メカニズムとmicroRNAによるその制御機構の解明

    2014.12 - 2016.11

    武田科学振興財団医学系研究奨励 

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    Grant type:Competitive

  9. ヒスタミン受容体H4をターゲットとした、加齢黄斑変性に対する内服治療薬の検討

    2014.11 - 2015.6

    横山臨床薬理研究助成基金研究助成 

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    Grant type:Competitive

  10. 脂質代謝産物マロンジアルデヒドの抑制による加齢黄斑変性予防効果の検討

    2014.9 - 2015.8

    代謝異常治療研究基金研究助成 

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    Grant type:Competitive

  11. 萎縮型加齢黄斑変性における炎症性サイトカインの関与についての研究

    2013.3 - 2014.3

    中京長寿医療研究推進団医学研究助成金 

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    Grant type:Competitive

  12. 糖尿病網膜症における網膜神経障害と ω3脂肪酸による神経保護作用

    公益財団法人市原国際奨学財団 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\500000

  13. 難治性網膜疾患と炎症性サイトカイン

    公益財団法人豊秋奨学 

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    Grant type:Competitive

    Grant amount:\200000

  14. ミュラーグリア細胞を介したω3脂肪酸による糖尿病網膜症治療

    公益財団法人高齢者眼疾患研究財団 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 萎縮型加齢黄斑変性のモデルマウス確立と、その病態の解明

    2013.4 - 2017.3

    科学研究費補助金  若手研究(A)

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    Authorship:Principal investigator 

  2. 抗アレルギー治療は滲出型加齢黄斑変性に対する新たな治療法になりえるのか?

    2013.4 - 2016.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  3. Comprehensive pathological analysis of detached retina and development of new treatment for the cell protection

    Grant number:15H04994  2015.4 - 2018.3

    Terasaki Hiroko

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    Authorship:Coinvestigator(s) 

    We examined the recovery of disorganized retinal structure and function using ERG, optical coherence tomography (OCT), adoptive optics (AO), and LSFG. Cone interdigitation zone and the increased area of the retinal outer layer were correlated significantly with ERG b-wave amplitude improvement. Observation using the AO fundus camera showed the increased cone cell density after the scleral buckle surgery but it was less than that of the fellow eye. In the case of vitreous surgery for the retinal detachment, the retinal blood flow on the optic disc decreased before surgery but recovered after surgery. New prototype fiber-optic OCT was developed and clinically used for the patients. Biological analysis detected increased IL-1beta in the subretinal fluid in retinal detachment and specific expression of miR148a in the vitreous of eyes with retinal detachment. Higher expression of caveolin-1 in the fibrotic membrane in PVR had a role for preventing PVR pathogenesis.