研究者詳細 - 小倉　靖弘

論文 - 小倉　靖弘

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Cytomegalovirus (CMV) Monitoring After Liver Transplantation: Comparison of CMV Pp65 Antigenemia Assay with Real-Time PCR Calibrated to WHO International Standard.

Kamei H, Ito Y, Onishi Y, Suzuki M, Imai H, Kurata N, Hori T, Tainaka T, Uchida H, Ogura Y

Annals of transplantation 21 巻頁： 131 - 6 2016年3月

Living Donor Liver Transplantation Using a Liver Graft With Congenital Intrahepatic Portosystemic Shunt

Kamei Hideya, Imai Hisashi, Onishi Yasuharu, Sugimoto Hiroyuki, Suzuki Kojiro, Ogura Yasuhiro

TRANSPLANTATION DIRECT 2 巻 ( 1 ) 頁： e46 2016年1月

Development of extensive inferior vena cava thrombosis due to the ligation of a large mesenteric-caval shunt during liver transplantation: A case report

Kamei Hideya, Onishi Yasuharu, Ishigami Masatoshi, Ishizu Yoji, Suzuki Kojiro, Ogura Yasuhiro

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS 29 巻頁： 211 - 214 2016年

Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantation

Hori Tomohide, Onishi Yasuharu, Kamei Hideya, Kurata Nobuhiko, Ishigami Masatoshi, Ishizu Yoji, Ogura Yasuhiro

ANNALS OF GASTROENTEROLOGY 29 巻 ( 4 ) 頁： 454 - 459 2016年

Current status of deceased donor split liver transplantation in Japan

Sakamoto Seisuke, Kasahara Mureo, Ogura Yasuhiro, Inomata Yukihiro, Uemoto Shinji

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES 22 巻 ( 12 ) 頁： 837 - 845 2015年12月

Successful Living-Donor Liver Transplantation for Cholestatic Liver Failure Induced by Allopurinol: Case Report

Imai, H; Kamei, H; Onishi, Y; Yamada, K; Ishizu, Y; Ishigami, M; Goto, H; Ogura, Y

TRANSPLANTATION PROCEEDINGS 47 巻 ( 9 ) 頁： 2778 - 2781 2015年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Transplantation Proceedings

A 39-year-old man was diagnosed with allopurinol-induced hepatic injury. He did not show any sign of hepatic encephalopathy, but his serum total bilirubin level was >40 mg/dL when he visited the local hospital. The therapeutic effects of initial medical treatments were transient, and both renal function and coagulation ability were gradually deteriorated. Four months after the onset of hepatic injury, he was referred to our hospital for the purpose of liver transplantation (LT). Although he was wasting and severely jaundiced, his consciousness level was not disturbed at all, with normal serum ammonia blood concentration before LT. Owing to allopurinol-induced severe cholestatic liver failure, living-donor LT (LDLT) was performed with the use of a right lobe graft from his younger brother. The explanted liver was extremely enlarged, with a weight of 2,480 g, and severely cholestatic. Microscopic findings were also compatible with drug-induced cholestatic liver injury. He was discharged from hospital 55 days after LDLT, whereas his renal dysfunction remained at 6 months after LT. There are 3 types of pathophysiology of drug-induced hepatotoxicity: hepatocellular, cholestatic, and mixed liver injury. Although allopurinol hepatotoxicity is rare, it can be severe and even fatal. This is the 1st case report of successful LDLT for a patient who had developed allopurinol-induced cholestatic liver failure.

DOI： 10.1016/j.transproceed.2015.09.038

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Considerable Risk of Restenosis After Endoscopic Treatment for Hepaticojejunostomy Stricture After Living-Donor Liver Transplantation

Kamei H., Imai H., Onishi Y., Ishihara M., Nakamura M., Kawashima H., Ishigami M., Ito A., Ohmiya N., Hirooka Y., Goto H., Ogura Y.

TRANSPLANTATION PROCEEDINGS 47 巻 ( 8 ) 頁： 2493 - 2498 2015年10月

Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation

Ishigami Masatoshi, Ogura Yasuhiro, Hirooka Yoshiki, Goto Hidemi

WORLD JOURNAL OF GASTROENTEROLOGY 21 巻 ( 36 ) 頁： 10290 - 10298 2015年9月

Changes in Surgical Site Infections after Living Donor Liver Transplantation

Yamamoto Masaki, Takakura Shunji, Iinuma Yoshitsugu, Hotta Go, Matsumura Yasufumi, Matsushima Aki, Nagao Miki, Ogawa Kohei, Fujimoto Yasuhiro, Mori Akira, Ogura Yasuhiro, Kaido Toshimi, Uemoto Shinji, Ichiyama Satoshi

PLOS ONE 10 巻 ( 8 ) 頁： e0136559 2015年8月

Liver Transplantation for Non-B and Non-C Hepatocellular Carcinoma.

Kaido T, Mori A, Ogura Y, Hata K, Yoshizawa A, lida T, Yagi S, Uemoto S

Hepato-gastroenterology 62 巻 ( 140 ) 頁： 933 - 6 2015年6月

Liver Transplantation in Adults with Acute Liver Failure: A Single Center Experience over A Period of 15 Years.

Kaido T, Ogawa K, Ogura Y, Hata K, Yoshizawa A, Yagi S, Ito T, Uemoto S

Hepato-gastroenterology 62 巻 ( 140 ) 頁： 937 - 41 2015年6月

Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients

Kawano Yoshihiko, Suzuki Michio, Kawada Jun-ichi, Kimura Hiroshi, Kamei Hideya, Ohnishi Yasuharu, Ono Yasuyuki, Uchida Hiroo, Ogura Yasuhiro, Ito Yoshinori

VACCINE 33 巻 ( 12 ) 頁： 1440 - 1445 2015年3月

Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans

Fujii Yukiko, Niisoe Tamon, Harada Kouji H., Uemoto Shinji, Ogura Yasuhiro, Takenaka Katsunobu, Koizum Akio

JOURNAL OF OCCUPATIONAL HEALTH 57 巻 ( 1 ) 頁： 1 - 12 2015年1月

Postoperative Psychiatric Complications in Living Liver Donors

Kimura H., Onishi Y., Sunada S., Kish S., Suzuki N., Tsuboi C., Yannaguchi N., Imai H., Kamei H., Fujisiro H., Okada T., Ishigami M., Ogura Y., Kiuchi T., Ozaki N.

TRANSPLANTATION PROCEEDINGS 47 巻 ( 6 ) 頁： 1860 - 1865 2015年

Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans.

Fujii Y, Niisoe T, Harada KH, Uemoto S, Ogura Y, Takenaka K, Koizumi A

Journal of occupational health 57 巻 ( 1 ) 頁： 1 - 12 2015年

Successful adult-to-adult living donor liver transplantation using liver allograft after the resection of hemangioma: A suggestive case for a further expansion of living donor pool

Onishi Y., Kamei H., Imai H., Kurata N., Hori T., Ogura Y.

International Journal of Surgery Case Reports 16 巻頁： 166 - 170 2015年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Surgery Case Reports

Introduction Hepatic hemangioma is one of the most common benign liver tumors. There are few published reports regarding liver transplantation using liver allografts with hemangioma. Presentation of case A 45-year-old man was evaluated as a living donor for 19-year-old son with cirrhosis due to hepatic fibrosis. Preoperative investigations revealed 20 and 7 mm hemangiomas, at segment 2 (S2) and 4 (S4) respectively. Considering the anatomical relation of S2 hemangioma and Glisson 2, liver graft was designed as left lobe excluded S2 hemangioma by partial resection. Estimated graft recipient weight ratio (GRWR) even after partial resection of hemangioma was reasonable. During the donor operation, a partial hepatic resection of S2 hemangioma was performed. Intraoperative pathologic findings revealed a cavernous hemangioma, and then, the left hepatic graft with the caudate lobe was harvested. Actual GRWR was 0.90%. Donor's postoperative course was uneventful. Recipient's post-operative course was almost uneventful. Postoperative computed tomography of the recipient showed the graft regeneration without increase or recurrence of hemangioma. Discussion Organ shortage is a major concern in the field of liver transplantation. A novel donor source with a further option is extremely crucial for a guarantee of liver transplantation. We experienced the first case of adult-to-adult living donor liver transplantation using liver allograft after the resection of hemangioma. Conclusion We advocate that the use of liver allograft with hemangiomas in adult-to-adult LDLT settings can be remarkable strategy to reduce the problem of organ shortage without any unfavorable consequences in both living donor and recipient.

DOI： 10.1016/j.ijscr.2015.09.043

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Impact of preoperative uncontrollable hepatic hydrothorax and massive ascites in adult liver transplantation

Endo Kosuke, Iida Taku, Yagi Shintaro, Yoshizawa Atsushi, Fujimoto Yasuhiro, Ogawa Kohei, Ogura Yasuhiro, Mori Akira, Kaido Toshimi, Uemoto Shinji

SURGERY TODAY 44 巻 ( 12 ) 頁： 2293 - 2299 2014年12月

Urinary Neutrophil Gelatinase-Associated Lipocalin: A Useful Biomarker for Tacrolimus-Induced Acute Kidney Injury in Liver Transplant Patients

Tsuchimoto, A; Shinke, H; Uesugi, M; Kikuchi, M; Hashimoto, E; Sato, T; Ogura, Y; Hata, K; Fujimoto, Y; Kaido, T; Kishimoto, J; Yanagita, M; Matsubara, K; Uemoto, S; Masuda, S

PLOS ONE 9 巻 ( 10 ) 頁： e110527 2014年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

Tacrolimus is widely used as an immunosuppressant in liver transplantation, and tacrolimus-induced acute kidney injury (AKI) is a serious complication of liver transplantation. For early detection of AKI, various urinary biomarkers such as monocyte chemotactic protein-1, liver-type fatty acid-binding protein, interleukin-18, osteopontin, cystatin C, clusterin and neutrophil gelatinase-associated lipocalin (NGAL) have been identified. Here, we attempt to identify urinary biomarkers for the early detection of tacrolimus-induced AKI in liver transplant patients. Urine samples were collected from 31 patients after living-donor liver transplantation (LDLT). Twenty recipients developed tacrolimus-induced AKI. After the initiation of tacrolimus therapy, urine samples were collected on postoperative days 7, 14, and 21. In patients who experienced AKI during postoperative day 21, additional spot urine samples were collected on postoperative days 28, 35, 42, 49, and 58. The 8 healthy volunteers, whose renal and liver functions were normal, were asked to collect their blood and spot urine samples. The urinary levels of NGAL, monocyte chemotactic protein-1 and liver-type fatty acid-binding protein were significantly higher in patients with AKI than in those without, while those of interleukin-18, osteopontin, cystatin C and clusterin did not differ between the 2 groups. The area under the receiver operating characteristics curve of urinary NGAL was 0.876 (95% confidence interval, 0.800-0.951; P<0.0001), which was better than those of the other six urinary biomarkers. In addition, the urinary levels of NGAL at postoperative day 1 (p= 0.0446) and day 7 (p=0.0006) can be a good predictive marker for tacrolimus-induced AKI within next 6 days, respectively. In conclusion, urinary NGAL is a sensitive biomarker for tacrolimus-induced AKI, and may help predict renal event caused by tacrolimus therapy in liver transplant patients.

DOI： 10.1371/journal.pone.0110527

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Frequent Incidence of Escape Mutants After Successful Hepatitis B Vaccine Response and Stopping of Nucleos(t)ide Analogues in Liver Transplant Recipients

Ishigami Masatoshi, Honda Takashi, Ishizu Yoji, Onishi Yasuharu, Kamei Hideya, Hayashi Kazuhiko, Ogura Yasuhiro, Hirooka Yoshiki, Goto Hidemi

LIVER TRANSPLANTATION 20 巻 ( 10 ) 頁： 1211 - 1220 2014年10月

Plasma cell hepatitis induced by the termination of antiviral therapy for recurrent hepatitis C after living donor liver transplantation

Ueda Yoshihide, Yoshizawa Atsushi, Ogura Yasuhiro, Miyagawa-Hayashino Aya, Haga Hironori, Chiba Tsutomu, Uemoto Shinji

HEPATOLOGY RESEARCH 44 巻 ( 10 ) 頁： E279 - E283 2014年10月

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論文 - 小倉 靖弘

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論文 - 小倉　靖弘