Updated on 2021/07/09

写真a

 
OGURA Yasuhiro
 
Organization
Nagoya University Hospital Transplantation Surgery Professor of hospital
Title
Professor of hospital
Contact information
メールアドレス

Degree 1

  1. 博士(医学) ( 2002.7   京都大学 ) 

Research Interests 1

  1. liver transplantation

Research Areas 1

  1. Others / Others  / 移植外科

Education 1

  1. Kyoto University   Faculty of Medicine

    1985.4 - 1991.3

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    Country: Japan

Professional Memberships 7

  1. 日本外科学会

  2. 日本消化器外科学会

  3. 肝胆膵外科学会

  4. 日本肝臓学会

  5. 日本肝移植研究会

  6. International Liver Transplantation Society

  7. Japanese Society for Histocompatibility and Immunogenetics

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Papers 81

  1. Temporal dynamics of the plasma microbiome in recipients at early post-liver transplantation: a retrospective study.

    Okumura T, Horiba K, Kamei H, Takeuchi S, Suzuki T, Torii Y, Kawada JI, Takahashi Y, Ogura Y, Ogi T, Ito Y

    BMC microbiology   Vol. 21 ( 1 ) page: 104   2021.4

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    Publishing type:Research paper (scientific journal)   Publisher:BMC Microbiology  

    DOI: 10.1186/s12866-021-02154-w

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  2. Incidental intrahepatic cholangiocarcinoma in patients undergoing liver transplantation: A multi-center study in Japan.

    Hara T, Eguchi S, Yoshizumi T, Akamatsu N, Kaido T, Hamada T, Takamura H, Shimamura T, Umeda Y, Shinoda M, Ogura Y, Fukumoto T, Kasahara M, Hibi T, Umeshita K, Furukawa H, Ohdan H

    Journal of hepato-biliary-pancreatic sciences   Vol. 28 ( 4 ) page: 346 - 352   2021.4

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    DOI: 10.1002/jhbp.896

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  3. A novel anatomic variation of the intrahepatic biliary tree in live liver donor surgery: A case report

    Shizuku Masato, Kurata Nobuhiko, Jobara Kanta, Yoshizawa Atsushi, Ogura Yasuhiro

    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS   Vol. 79   page: 231 - 233   2021

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    Publishing type:Research paper (scientific journal)   Publisher:International Journal of Surgery Case Reports  

    DOI: 10.1016/j.ijscr.2021.01.042

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  4. De novo hepatocellular carcinoma in living donor liver grafts: A Japanese multicenter experience.

    Goto R, Kosai-Fujimoto Y, Yagi S, Kobayashi T, Akamatsu N, Shimamura T, Imura S, Ogiso S, Mizuno S, Takatsuki M, Fukuhara T, Kanto T, Eguchi S, Yanaga K, Ogura Y, Fukumoto T, Shimada M, Hasegawa K, Ohdan H, Uemoto S, Soejima Y, Ikegami T, Yoshizumi T, Taketomi A, Maehara Y

    Hepatology research : the official journal of the Japan Society of Hepatology   Vol. 50 ( 12 ) page: 1365 - 1374   2020.12

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    Publishing type:Research paper (scientific journal)   Publisher:Hepatology Research  

    DOI: 10.1111/hepr.13565

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  5. The role of living donor liver transplantation for acute liver failure

    Ogura Yasuhiro, Kabacam Gokhan, Singhal Ashish, Moon Deok-Bok

    INTERNATIONAL JOURNAL OF SURGERY   Vol. 82   page: 145 - 148   2020.10

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    Publishing type:Research paper (scientific journal)   Publisher:International Journal of Surgery  

    DOI: 10.1016/j.ijsu.2020.04.058

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  6. Revisiting the indications for liver transplantation in cirrhotic patients considering the long-term outcomes of cirrhotic patients.

    Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Kamei H, Ogura Y, Fujishiro M

    Journal of hepato-biliary-pancreatic sciences   Vol. 27 ( 9 ) page: 655 - 662   2020.9

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    Publishing type:Research paper (scientific journal)   Publisher:Journal of Hepato-Biliary-Pancreatic Sciences  

    DOI: 10.1002/jhbp.777

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  7. Portal Vein Stenosis Following Liver Transplantation Hemodynamically Assessed with 4D-flow MRI before and after Portal Vein Stenting.

    Hyodo R, Takehara Y, Mizuno T, Ichikawa K, Ogura Y, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2020.8

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    DOI: 10.2463/mrms.ici.2020-0057

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  8. Laparoscopic Kasai portoenterostomy is advantageous over open Kasai portoenterostomy in subsequent liver transplantation

    Shirota Chiyoe, Murase Naruhiko, Tanaka Yujiro, Ogura Yasuhiro, Nakatochi Masahiro, Kamei Hideya, Kurata Nobuhiko, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Uchida Hiroo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 34 ( 8 ) page: 3375 - 3381   2020.8

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    Publishing type:Research paper (scientific journal)   Publisher:Surgical Endoscopy  

    DOI: 10.1007/s00464-019-07108-y

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  9. Computational Fluid Dynamics-Based Blood Flow Assessment Facilitates Optimal Management of Portal Vein Stenosis After Liver Transplantation

    Ogiso Satoshi, Nakamura Masanori, Tanaka Takashi, Komiya Kenji, Kamei Hideya, Onishi Yasuharu, Jobara Kanta, Kurata Nobuhiko, Itatani Keiichi, Ogura Yasuhiro

    JOURNAL OF GASTROINTESTINAL SURGERY   Vol. 24 ( 2 ) page: 460 - 461   2020.2

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    Publishing type:Research paper (scientific journal)   Publisher:Journal of Gastrointestinal Surgery  

    DOI: 10.1007/s11605-019-04279-w

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  10. Clinical Features and Long-Term Outcomes of Living Donors of Liver Transplantation Who Developed Psychiatric Disorders

    Shizuku Masato, Kamei Hideya, Kimura Hiroyuki, Kurata Nobuhiko, Jobara Kanta, Yoshizawa Atsushi, Ishizuka Kanako, Okada Aoi, Kishi Shinichi, Ozaki Norio, Ogura Yasuhiro

    ANNALS OF TRANSPLANTATION   Vol. 25   page: e918500   2020.1

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    Publishing type:Research paper (scientific journal)   Publisher:Annals of Transplantation  

    DOI: 10.12659/AOT.918500

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  11. Decreased long-term graft survival in persistent biliary complications after right-lobe living-donor liver transplantation

    Ogiso Satoshi, Kamei Hideya, Onishi Yasuharu, Kurata Nobuhiko, Jobara Kanta, Kawashima Hiroki, Ogura Yasuhiro

    CLINICAL TRANSPLANTATION   Vol. 34 ( 1 ) page: e13771   2020.1

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    Publishing type:Research paper (scientific journal)   Publisher:Clinical Transplantation  

    DOI: 10.1111/ctr.13771

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  12. Budd-Chiari Syndrome Associated With Hypereosinophilic Syndrome Treated by Deceased-Donor Liver Transplantation: A Case Report

    Shizuku Masato, Kurata Nobuhiko, Jobara Kanta, Yoshizawa Atsushi, Kamei Hideya, Amano Nozomi, Genda Takuya, Ogura Yasuhiro

    TRANSPLANTATION PROCEEDINGS   Vol. 51 ( 9 ) page: 3140 - 3146   2019.11

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    Publishing type:Research paper (scientific journal)   Publisher:Transplantation Proceedings  

    DOI: 10.1016/j.transproceed.2019.08.003

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  13. Splenectomy in living donor liver transplantation and risk factors of portal vein thrombosis

    Kurata Nobuhiko, Ogura Yasuhiro, Ogiso Satoshi, Onishi Yasuharu, Kamei Hideya, Kodera Yasuhiro

    HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL   Vol. 18 ( 4 ) page: 337 - 342   2019.8

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    Publishing type:Research paper (scientific journal)   Publisher:Hepatobiliary and Pancreatic Diseases International  

    DOI: 10.1016/j.hbpd.2019.06.011

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  14. Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial

    Kaido Toshimi, Shinoda Masahiro, Inomata Yukihiro, Yagi Takahito, Akamatsu Nobuhisa, Takada Yasutsugu, Ohdan Hideki, Shimamura Tsuyoshi, Ogura Yasuhiro, Eguchi Susumu, Eguchi Hidetoshi, Ogata Satoshi, Yoshizumi Tomoharu, Ikegami Toshihiko, Yamamoto Michio, Morita Satoshi, Uemoto Shinji

    NUTRITION   Vol. 54   page: 68 - 75   2018.10

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    DOI: 10.1016/j.nut.2018.02.022

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  15. Risk factors and long-term outcomes of pediatric liver transplant recipients with chronic high Epstein-Barr virus loads

    Kamei Hideya, Ito Yoshinori, Kawada Junichi, Ogiso Satoshi, Onishi Yasuharu, Komagome Masahiko, Kurata Nobuhiko, Ogura Yasuhiro

    TRANSPLANT INFECTIOUS DISEASE   Vol. 20 ( 4 ) page: e12911   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tid.12911

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  16. Diagnostic Usefulness of APRI and FIB-4 for the Prediction of Liver Fibrosis After Liver Transplantation in Patients Infected with Hepatitis C Virus

    Imai H., Kamei H., Onishi Y., Ishizu Y., Ishigami M., Goto H., Ogura Y.

    TRANSPLANTATION PROCEEDINGS   Vol. 50 ( 5 ) page: 1431 - 1436   2018.6

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    DOI: 10.1016/j.transproceed.2018.03.005

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  17. Lung Metastases from Bile Duct Adenocarcinoma Mimicking Chronic Airway Infection and Causing Diagnostic Difficulty.

    Sato M, Okachi S, Fukihara J, Shimoyama Y, Wakahara K, Sakakibara T, Hase T, Onishi Y, Ogura Y, Maeda O, Hasegawa Y

    Internal medicine (Tokyo, Japan)   Vol. 57 ( 10 ) page: 1429 - 1432   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.9718-17

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  18. Brain death organ donor supported by a left ventricular assist device showing unexpected congestive liver fibrosis: A case report

    Kamei Hideya, Komagome Masahiko, Kurata Nobuhiko, Ogiso Satoshi, Onishi Yasuharu, Hara Takanobu, Takatsuki Mitsuhisa, Eguchi Susumu, Ogura Yasuhiro

    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS   Vol. 47   page: 57-60   2018

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    DOI: 10.1016/j.ijscr.2018.04.026

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  19. Successful Post-Transplant Psychiatric Interventions During Long-Term Follow-Up of Patients Receiving Liver Transplants for Alcoholic Liver Disease.

    Kimura H, Onishi Y, Kishi S, Kurata N, Ogiso S, Kamei H, Tsuboi C, Yamaguchi N, Shiga A, Kondo M, Yokoyama Y, Takasato F, Fujishiro H, Ishizuka K, Okada T, Ogura Y, Ozaki N

    The American journal of case reports   Vol. 18   page: 1215 - 1219   2017.11

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    DOI: 10.12659/AJCR.906446

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  20. A MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF EXTRACT OF JAPANESE HERBAL MEDICINE DAIKENCHUTO TO PREVENT BOWEL DYSFUNCTION AFTER ADULT LIVER TRANSPLANTATION (DKB 14 STUDY)

    Sugawara Yasuhiko, Kaido Toshimi, Shinoda Masahiro, Inomata Yukihoro, Yagi Takahito, Akamatsu Nobuhisa, Takada Yasutsugu, Ohdan Hideki, Shimamura Tsuyoshi, Ogura Yasuhiiro, Eguchi Susumu, Eguchi Hidetoshi, Yamamoto Masakazu, Maehara Yoshihiko, Miyagawa Shinichi, Uemoto Shinji

    TRANSPLANT INTERNATIONAL   Vol. 30   page: 351-351   2017.9

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  21. SUCCESSFUL SERIES OF RITUXIMAB DESENSITIZATION FOR LIVER TRANSPLANTATION WITH PREFORMED DONOR SPECIFIC ANTIBODIES

    Ogura Yasuhiro, Kamei Hideya, Komagome Masahiko, Kurata Nobuhiko, Onishi Yasuharu

    TRANSPLANT INTERNATIONAL   Vol. 30   page: 57-57   2017.9

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  22. Successful Blood Transfusion Management of a Living Donor Liver Transplant Recipient in the Presence of Anti-Jr(a): A Case Report

    Kurata N., Onishi Y., Kamei H., Hori T., Komagome M., Kato C., Matsushita T., Ogura Y.

    TRANSPLANTATION PROCEEDINGS   Vol. 49 ( 7 ) page: 1604 - 1607   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.transproceed.2017.06.009

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  23. Donor Selection and Prophylactic Strategy for Venous Thromboembolic Events in Living Donors of Liver Transplantation Based on Results of Thrombophilia Screening Tests

    Kamei Hideya, Onishi Yasuharu, Kurata Nobuhiko, Ishigami Masatoshi, Ogura Yasuhiro

    ANNALS OF TRANSPLANTATION   Vol. 22   page: 409-416   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.12659/AOT.902791

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  24. Donor Selection and Prophylactic Strategy for Venous Thromboembolic Events in Living Donors of Liver Transplantation Based on Results of Thrombophilia Screening Tests.

    Kamei H, Onishi Y, Kurata N, Ishigami M, Ogura Y

    Annals of transplantation   Vol. 22   page: 409-416   2017.7

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  25. Rituximab Desensitization for Liver Transplantaiton with Preformed Donor Specific Antibodies

    Ogura Y., Kamei H., Komagome M., Kurata N., Onishi Y.

    TRANSPLANTATION   Vol. 101 ( 5 ) page: 206-207   2017.5

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  26. A Multicenter, Randomized, Placebo-controlled Trial of Extract of Japanese Herbal Medicine Daikenchuto to Prevent Bowel Dysfunction after Adult Liver Transplantation (DKB 14 Study)

    Mizota T., Kaido T., Shinoda M., Hibi T., Inomata Y., Yagi T., Akamatsu N., Takada Y., Ohdan H., Shimamura T., Ogura Y., Eguchi S., Eguchi H., Yamamoto M., Maehara Y., Miyagawa S., Uemoto S.

    TRANSPLANTATION   Vol. 101 ( 5 ) page: 157-158   2017.5

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  27. Chronic High Epstein-Bar Virus Loads in Pediatric Liver Transplant Recipients - Risk Factors and Long-term Outcomes

    Kamei H., Ito Y., Ohnishi Y., Kawada J., Kurata N., Komagome M., Ogura Y.

    TRANSPLANTATION   Vol. 101 ( 5 ) page: 83-83   2017.5

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  28. Risk of alcohol use relapse after liver transplantation for alcoholic liver disease

    Onishi Yasuharu, Kimura Hiroyuki, Hori Tomohide, Kishi Shinichi, Kamei Hideya, Kurata Nobuhiko, Tsuboi Chisato, Yamaguchi Naoko, Takahashi Mayu, Sunada Saki, Hirano Mitsuaki, Fujishiro Hiroshige, Okada Takashi, Ishigami Masatoshi, Goto Hidemi, Ozaki Norio, Ogura Yasuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 23 ( 5 ) page: 869 - 875   2017.2

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    DOI: 10.3748/wjg.v23.i5.869

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  29. Changes in Muscle Strength and Six-Minute Walk Distance Before and After Living Donor Liver Transplantation

    Mizuno Y., Ito S., Hattori K., Nagaya M., Inoue T., Nishida Y., Onishi Y., Kamei H., Kurata N., Hasegawa Y., Ogura Y.

    TRANSPLANTATION PROCEEDINGS   Vol. 48 ( 10 ) page: 3348 - 3355   2016.12

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    Publishing type:Research paper (scientific journal)   Publisher:Transplantation Proceedings  

    DOI: 10.1016/j.transproceed.2016.08.042

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  30. Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation

    Hori Tomohide, Ogura Yasuhiro, Onishi Yasuharu, Kamei Hideya, Kurata Nobuhiko, Kainuma Motoshi, Takahashi Hideo, Suzuki Shogo, Ichikawa Takashi, Mizuno Shoko, Aoyama Tadashi, Ishida Yuki, Hirai Takahiro, Hayashi Tomoko, Hasegawa Kazuko, Takeichi Hiromu, Ota Atsunobu, Kodera Yasuhiro, Sugimoto Hiroyuki, Iida Taku, Yagi Shintaro, Taniguchi Kentaro, Uemoto Shinji

    WORLD JOURNAL OF HEPATOLOGY   Vol. 8 ( 25 ) page: 1047 - 1060   2016.9

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    Publishing type:Research paper (scientific journal)   Publisher:World Journal of Hepatology  

    DOI: 10.4254/wjh.v8.i25.1047

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  31. Fibrosing Cholestatic Hepatitis in a Complicated Case of an Adult Recipient After Liver Transplantation: Diagnostic Findings and Therapeutic Dilemma

    Hori Tomohide, Onishi Yasuharu, Kamei Hideya, Kurata Nobuhiko, Ishigami Masatoshi, Ishizu Yoji, Ogura Yasuhiro

    AMERICAN JOURNAL OF CASE REPORTS   Vol. 17   page: 597 - 604   2016.8

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    Publishing type:Research paper (scientific journal)   Publisher:American Journal of Case Reports  

    DOI: 10.12659/AJCR.898427

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  32. Early Conversion From Twice-Daily Tacrolimus to Prolonged-Release Tacrolimus in Liver Transplantation: A Single-Center Experience

    Ogura Yasuhiro, Imai Hisashi, Kamei Hideya, Hori Tomohide, Kurata Nobuhiko, Onishi Yasuharu

    ANNALS OF TRANSPLANTATION   Vol. 21   page: 448 - 55   2016.7

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    Publishing type:Research paper (scientific journal)   Publisher:Annals of Transplantation  

    DOI: 10.12659/AOT.898604

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  33. How far can we lower graft-to-recipient weight ratio for living donor liver transplantation under modulation of portal venous pressure?

    Uemura Tadahiro, Wada Seidai, Kaido Toshimi, Mori Akira, Ogura Yasuhiro, Yagi Shintaro, Fujimoto Yasuhiro, Ogawa Kohei, Hata Koichiro, Yoshizawa Atsushi, Okajima Hideaki, Uemoto Shinji

    SURGERY   Vol. 159 ( 6 ) page: 1623 - 1630   2016.6

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    Publishing type:Research paper (scientific journal)   Publisher:Surgery (United States)  

    DOI: 10.1016/j.surg.2016.01.009

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  34. Impact of human T-cell leukemia virus type 1 on living donor liver transplantation: a multi-center study in Japan

    Yoshizumi Tomoharu, Takada Yasutsugu, Shirabe Ken, Kaido Toshimi, Hidaka Masaaki, Honda Masaki, Ito Takashi, Shinoda Masahiro, Ohdan Hideki, Kawagishi Naoki, Sugawara Yasuhiko, Ogura Yasuhiro, Kasahara Mureo, Kubo Shoji, Taketomi Akinobu, Yamashita Natsumi, Uemoto Shinji, Yamaue Hiroki, Miyazaki Masaru, Takada Tadahiro, Maehara Yoshihiko

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 23 ( 6 ) page: 333 - 341   2016.6

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    DOI: 10.1002/jhbp.345

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  35. Outcomes of Living Donor Liver Transplantation Alone for Patients on Maintenance Renal Replacement Therapy in Japan: Results of a Nationwide Survey.

    Eguchi S, Furukawa H, Uemoto S, Umeshita K, Imamura H, Soyama A, Shimamura T, Isaji S, Ogura Y, Egawa H, Kawachi S, Kasahara M, Nagano H, Ku Y, Ohdan H, Maehara Y, Sato S, Inomata Y

    Transplantation direct   Vol. 2 ( 6 ) page: e74   2016.6

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/TXD.0000000000000587

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  36. Cytomegalovirus (CMV) Monitoring After Liver Transplantation: Comparison of CMV Pp65 Antigenemia Assay with Real-Time PCR Calibrated to WHO International Standard.

    Kamei H, Ito Y, Onishi Y, Suzuki M, Imai H, Kurata N, Hori T, Tainaka T, Uchida H, Ogura Y

    Annals of transplantation   Vol. 21   page: 131 - 6   2016.3

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    Publishing type:Research paper (scientific journal)   Publisher:Annals of Transplantation  

    DOI: 10.12659/aot.895677

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  37. Living Donor Liver Transplantation Using a Liver Graft With Congenital Intrahepatic Portosystemic Shunt

    Kamei Hideya, Imai Hisashi, Onishi Yasuharu, Sugimoto Hiroyuki, Suzuki Kojiro, Ogura Yasuhiro

    TRANSPLANTATION DIRECT   Vol. 2 ( 1 ) page: e46   2016.1

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    DOI: 10.1097/TXD.0000000000000562

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  38. Development of extensive inferior vena cava thrombosis due to the ligation of a large mesenteric-caval shunt during liver transplantation: A case report

    Kamei Hideya, Onishi Yasuharu, Ishigami Masatoshi, Ishizu Yoji, Suzuki Kojiro, Ogura Yasuhiro

    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS   Vol. 29   page: 211 - 214   2016

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    Publishing type:Research paper (scientific journal)   Publisher:International Journal of Surgery Case Reports  

    DOI: 10.1016/j.ijscr.2016.11.012

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  39. Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantation

    Hori Tomohide, Onishi Yasuharu, Kamei Hideya, Kurata Nobuhiko, Ishigami Masatoshi, Ishizu Yoji, Ogura Yasuhiro

    ANNALS OF GASTROENTEROLOGY   Vol. 29 ( 4 ) page: 454 - 459   2016

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    Publishing type:Research paper (scientific journal)   Publisher:Annals of Gastroenterology  

    DOI: 10.20524/aog.2016.0069

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  40. Current status of deceased donor split liver transplantation in Japan

    Sakamoto Seisuke, Kasahara Mureo, Ogura Yasuhiro, Inomata Yukihiro, Uemoto Shinji

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 22 ( 12 ) page: 837 - 845   2015.12

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    Publishing type:Research paper (scientific journal)   Publisher:Journal of Hepato-Biliary-Pancreatic Sciences  

    DOI: 10.1002/jhbp.292

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  41. Successful Living-Donor Liver Transplantation for Cholestatic Liver Failure Induced by Allopurinol: Case Report

    Imai H., Kamei H., Onishi Y., Yamada K., Ishizu Y., Ishigami M., Goto H., Ogura Y.

    TRANSPLANTATION PROCEEDINGS   Vol. 47 ( 9 ) page: 2778 - 2781   2015.11

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    Publishing type:Research paper (scientific journal)   Publisher:Transplantation Proceedings  

    DOI: 10.1016/j.transproceed.2015.09.038

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  42. Considerable Risk of Restenosis After Endoscopic Treatment for Hepaticojejunostomy Stricture After Living-Donor Liver Transplantation

    Kamei H., Imai H., Onishi Y., Ishihara M., Nakamura M., Kawashima H., Ishigami M., Ito A., Ohmiya N., Hirooka Y., Goto H., Ogura Y.

    TRANSPLANTATION PROCEEDINGS   Vol. 47 ( 8 ) page: 2493 - 2498   2015.10

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    DOI: 10.1016/j.transproceed.2015.09.015

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  43. Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation

    Ishigami Masatoshi, Ogura Yasuhiro, Hirooka Yoshiki, Goto Hidemi

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 21 ( 36 ) page: 10290 - 10298   2015.9

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    Publishing type:Research paper (scientific journal)   Publisher:World Journal of Gastroenterology  

    DOI: 10.3748/wjg.v21.i36.10290

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  44. Changes in Surgical Site Infections after Living Donor Liver Transplantation

    Yamamoto Masaki, Takakura Shunji, Iinuma Yoshitsugu, Hotta Go, Matsumura Yasufumi, Matsushima Aki, Nagao Miki, Ogawa Kohei, Fujimoto Yasuhiro, Mori Akira, Ogura Yasuhiro, Kaido Toshimi, Uemoto Shinji, Ichiyama Satoshi

    PLOS ONE   Vol. 10 ( 8 ) page: e0136559   2015.8

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    Publishing type:Research paper (scientific journal)   Publisher:PLoS ONE  

    DOI: 10.1371/journal.pone.0136559

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  45. Liver Transplantation for Non-B and Non-C Hepatocellular Carcinoma.

    Kaido T, Mori A, Ogura Y, Hata K, Yoshizawa A, lida T, Yagi S, Uemoto S

    Hepato-gastroenterology   Vol. 62 ( 140 ) page: 933 - 6   2015.6

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  46. Liver Transplantation in Adults with Acute Liver Failure: A Single Center Experience over A Period of 15 Years.

    Kaido T, Ogawa K, Ogura Y, Hata K, Yoshizawa A, Yagi S, Ito T, Uemoto S

    Hepato-gastroenterology   Vol. 62 ( 140 ) page: 937 - 41   2015.6

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  47. Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients

    Kawano Yoshihiko, Suzuki Michio, Kawada Jun-ichi, Kimura Hiroshi, Kamei Hideya, Ohnishi Yasuharu, Ono Yasuyuki, Uchida Hiroo, Ogura Yasuhiro, Ito Yoshinori

    VACCINE   Vol. 33 ( 12 ) page: 1440 - 1445   2015.3

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    DOI: 10.1016/j.vaccine.2015.01.075

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  48. Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans

    Fujii Yukiko, Niisoe Tamon, Harada Kouji H., Uemoto Shinji, Ogura Yasuhiro, Takenaka Katsunobu, Koizum Akio

    JOURNAL OF OCCUPATIONAL HEALTH   Vol. 57 ( 1 ) page: 1 - 12   2015.1

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  49. Postoperative Psychiatric Complications in Living Liver Donors

    Kimura H., Onishi Y., Sunada S., Kish S., Suzuki N., Tsuboi C., Yannaguchi N., Imai H., Kamei H., Fujisiro H., Okada T., Ishigami M., Ogura Y., Kiuchi T., Ozaki N.

    TRANSPLANTATION PROCEEDINGS   Vol. 47 ( 6 ) page: 1860 - 1865   2015

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    DOI: 10.1016/j.transproceed.2015.06.021

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  50. Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans.

    Fujii Y, Niisoe T, Harada KH, Uemoto S, Ogura Y, Takenaka K, Koizumi A

    Journal of occupational health   Vol. 57 ( 1 ) page: 1 - 12   2015

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    DOI: 10.1539/joh.14-0136-OA

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  51. Successful adult-to-adult living donor liver transplantation using liver allograft after the resection of hemangioma: A suggestive case for a further expansion of living donor pool

    Onishi Yasuharu, Kamei Hideya, Imai Hisashi, Kurata Nobuhiko, Hori Tomohide, Ogura Yasuhiro

    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS   Vol. 16   page: 166 - 170   2015

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    DOI: 10.1016/j.ijscr.2015.09.043

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  52. Impact of preoperative uncontrollable hepatic hydrothorax and massive ascites in adult liver transplantation

    Endo Kosuke, Iida Taku, Yagi Shintaro, Yoshizawa Atsushi, Fujimoto Yasuhiro, Ogawa Kohei, Ogura Yasuhiro, Mori Akira, Kaido Toshimi, Uemoto Shinji

    SURGERY TODAY   Vol. 44 ( 12 ) page: 2293 - 2299   2014.12

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    DOI: 10.1007/s00595-014-0839-y

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  53. Urinary Neutrophil Gelatinase-Associated Lipocalin: A Useful Biomarker for Tacrolimus-Induced Acute Kidney Injury in Liver Transplant Patients

    Tsuchimoto Ayami, Shinke Haruka, Uesugi Miwa, Kikuchi Mio, Hashimoto Emina, Sato Tomoko, Ogura Yasuhiro, Hata Koichiro, Fujimoto Yasuhiro, Kaido Toshimi, Kishimoto Junji, Yanagita Motoko, Matsubara Kazuo, Uemoto Shinji, Masuda Satohiro

    PLOS ONE   Vol. 9 ( 10 ) page: e110527   2014.10

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    DOI: 10.1371/journal.pone.0110527

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  54. Frequent Incidence of Escape Mutants After Successful Hepatitis B Vaccine Response and Stopping of Nucleos(t)ide Analogues in Liver Transplant Recipients

    Ishigami Masatoshi, Honda Takashi, Ishizu Yoji, Onishi Yasuharu, Kamei Hideya, Hayashi Kazuhiko, Ogura Yasuhiro, Hirooka Yoshiki, Goto Hidemi

    LIVER TRANSPLANTATION   Vol. 20 ( 10 ) page: 1211 - 1220   2014.10

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    Publishing type:Research paper (scientific journal)   Publisher:Liver Transplantation  

    DOI: 10.1002/lt.23935

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  55. Plasma cell hepatitis induced by the termination of antiviral therapy for recurrent hepatitis C after living donor liver transplantation

    Ueda Yoshihide, Yoshizawa Atsushi, Ogura Yasuhiro, Miyagawa-Hayashino Aya, Haga Hironori, Chiba Tsutomu, Uemoto Shinji

    HEPATOLOGY RESEARCH   Vol. 44 ( 10 ) page: E279 - E283   2014.10

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    DOI: 10.1111/hepr.12243

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  56. Hepatic arterial complications in adult living donor liver transplant recipients: a single-center experience of 673 cases

    Iida T., Kaido T., Yagi S., Hori T., Uchida Y., Jobara K., Tanaka H., Sakamoto S., Kasahara M., Ogawa K., Ogura Y., Mori A., Uemoto S.

    CLINICAL TRANSPLANTATION   Vol. 28 ( 9 ) page: 1025 - 1030   2014.9

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    DOI: 10.1111/ctr.12412

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  57. Living Donor Liver Transplantation Using a Right Liver Graft With Additional Vein Reconstructions for Patient With Situs Inversus

    Kamei H., Onishi Y., Ogawa K., Uemoto S., Ogura Y.

    AMERICAN JOURNAL OF TRANSPLANTATION   Vol. 14 ( 6 ) page: 1453 - 1458   2014.6

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    DOI: 10.1111/ajt.12692

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  58. SECTION 7. A NEW THERAPEUTIC STRATEGY ON PORTAL FLOW MODULATION THAT INCREASES DONOR SAFETY WITH GOOD RECIPIENT OUTCOMES

    Kaido Toshimi, Ogawa Kohei, Fujimoto Yasuhiro, Ito Takashi, Tomiyama Koji, Mori Akira, Ogura Yasuhiro, Uemoto Shinji

    TRANSPLANTATION   Vol. 97 ( 8 ) page: S30 - S32   2014.4

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    DOI: 10.1097/01.tp.0000446271.28557.e8

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  59. Graft Reconditioning With Nitric Oxide Gas in Rat Liver Transplantation From Cardiac Death Donors

    Kageyama Shoichi, Yagi Shintaro, Tanaka Hirokazu, Saito Shunichi, Nagai Kazuyuki, Hata Koichiro, Fujimoto Yasuhiro, Ogura Yasuhiro, Tolba Rene, Shinji Uemoto

    TRANSPLANTATION   Vol. 97 ( 6 ) page: 618 - 625   2014.3

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    DOI: 10.1097/TP.0000000000000025

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  60. How Do Transplant Surgeons Accomplish Optimal Portal Venous Flow During Living-Donor Liver Transplantation? Noninvasive Measurement of Indocyanine Green Elimination Rate

    Hori Tomohide, Ogura Yasuhiro, Yagi Shintaro, Iida Taku, Taniguchi Kentaro, El Moghazy Walid M., Hedaya Mohammed Saied, Segawa Hajime, Ogawa Kohei, Kogure Takayuki, Uemoto Shinji

    SURGICAL INNOVATION   Vol. 21 ( 1 ) page: 43 - 51   2014.2

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    DOI: 10.1177/1553350613487803

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  61. Graft harvest of right posterior segment for living-donor liver transplantation.

    Hori T, Oike F, Ogura Y, Ogawa K, Uemoto S

    International journal of surgery case reports   Vol. 5 ( 8 ) page: 516 - 22   2014

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    DOI: 10.1016/j.ijscr.2014.04.015

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  62. [Deceased donor liver transplantation receiving a liver from a child under six years old: an experience of organ retrieval from a pediatric donor in Japan].

    Hamano I, Sakamoto S, Fukuda A, Uchida H, Sasaki K, Shigeta T, Kanazawa H, Nakazawa A, Kasahara M, Ogura Y, Uemoto S

    Nihon Geka Gakkai zasshi   Vol. 114 ( 6 ) page: 340 - 4   2013.11

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  63. Living donor liver transplantation for Budd-Chiari syndrome with hepatic inferior vena cava obstruction after open pericardial procedures

    Fukuda Akinari, Ogura Yasuhiro, Kanazawa Hiroyuki, Mori Akira, Kawaguchi Michiya, Takada Yasutsugu, Uemoto Shinji

    SURGERY TODAY   Vol. 43 ( 10 ) page: 1180 - 1184   2013.10

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    DOI: 10.1007/s00595-012-0440-1

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  64. Cytokine gene polymorphisms in acute cellular rejection following living donor liver transplantation: analysis of 155 donor-recipient pairs

    Kamei Hideya, Masuda Satohiro, Nakamura Taro, Ishigami Masatoshi, Fujimoto Yasuhiro, Ogura Yasuhiro, Oike Fumitaka, Takada Yasutsugu, Hamajima Nobuyuki

    HEPATOLOGY INTERNATIONAL   Vol. 7 ( 3 ) page: 916 - 922   2013.7

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    Publishing type:Research paper (scientific journal)   Publisher:Hepatology International  

    DOI: 10.1007/s12072-013-9443-2

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  65. Impact of Sarcopenia on Survival in Patients Undergoing Living Donor Liver Transplantation

    Kaido T., Ogawa K., Fujimoto Y., Ogura Y., Hata K., Ito T., Tomiyama K., Yagi S., Mori A., Uemoto S.

    AMERICAN JOURNAL OF TRANSPLANTATION   Vol. 13 ( 6 ) page: 1549 - 1556   2013.6

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    DOI: 10.1111/ajt.12221

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  66. Pretransplant Serum Hepatitis C Virus RNA Levels Predict Response to Antiviral Treatment after Living Donor Liver Transplantation

    Ueda Yoshihide, Kaido Toshimi, Ogura Yasuhiro, Ogawa Kohei, Yoshizawa Atsushi, Hata Koichiro, Fujimoto Yasuhiro, Miyagawa-Hayashino Aya, Haga Hironori, Marusawa Hiroyuki, Teramukai Satoshi, Uemoto Shinji, Chiba Tsutomu

    PLOS ONE   Vol. 8 ( 3 ) page: e58380   2013.3

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    DOI: 10.1371/journal.pone.0058380

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  67. Efficacy and safety of prophylaxis with entecavir and hepatitis B immunoglobulin in preventing hepatitis B recurrence after living-donor liver transplantation

    Ueda Yoshihide, Marusawa Hiroyuki, Kaido Toshimi, Ogura Yasuhiro, Ogawa Kohei, Yoshizawa Atsushi, Hata Koichiro, Fujimoto Yasuhiro, Nishijima Norihiro, Chiba Tsutomu, Uemoto Shinji

    HEPATOLOGY RESEARCH   Vol. 43 ( 1 ) page: 67 - 71   2013.1

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    DOI: 10.1111/j.1872-034X.2012.01020.x

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  68. Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation

    Kamei Hideya, Masuda Satohiro, Nakamura Taro, Fujimoto Yasuhiro, Oike Fumitaka, Ogura Yasuhiro, Takada Yasutsugu, Hamajima Nobuyuki

    TRANSPLANT IMMUNOLOGY   Vol. 28 ( 1 ) page: 14 - 17   2013.1

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    Publishing type:Research paper (scientific journal)   Publisher:Transplant Immunology  

    DOI: 10.1016/j.trim.2012.11.002

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  69. Pediatric Liver Transplantation Using Reduced and Hyper-Reduced Left Lateral Segment Grafts: A 10-Year Single-Center Experience

    Shehata M. R., Yagi S., Okamura Y., Iida T., Hori T., Yoshizawa A., Hata K., Fujimoto Y., Ogawa K., Okamoto S., Ogura Y., Mori A., Teramukai S., Kaido T., Uemoto S.

    AMERICAN JOURNAL OF TRANSPLANTATION   Vol. 12 ( 12 ) page: 3406 - 3413   2012.12

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    DOI: 10.1111/j.1600-6143.2012.04268.x

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  70. Liver transplantation for severe hepatitis in patients with common variable immunodeficiency

    Murakawa Yasuhiro, Miyagawa-Hayashino Aya, Ogura Yasuhiro, Egawa Hiroto, Okamoto Shinya, Soejima Yuji, Kurosawa Manabu, Sumiyoshi Shinji, Uemoto Shinji, Haga Hironori

    PEDIATRIC TRANSPLANTATION   Vol. 16 ( 6 ) page: E210 - E216   2012.9

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    DOI: 10.1111/j.1399-3046.2011.01545.x

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  71. Non-inflammatory centrilobular sinusoidal fibrosis in pediatric liver transplant recipients under tacrolimus withdrawal

    Egawa Hiroto, Miyagawa-Hayashino Aya, Haga Hironori, Teramukai Satoshi, Yoshizawa Atsushi, Ogawa Kohei, Ogura Yasuhiro, Okamoto Shinya, Kaido Toshimi, Uemoto Shinji

    HEPATOLOGY RESEARCH   Vol. 42 ( 9 ) page: 895 - 903   2012.9

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    DOI: 10.1111/j.1872-034X.2012.01003.x

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  72. Effects of Post-transplant Enteral Nutrition with an Immunomodulating Diet Containing Hydrolyzed Whey Peptide after Liver Transplantation

    Kaido Toshimi, Ogura Yasuhiro, Ogawa Kohei, Hata Koichiro, Yoshizawa Atsushi, Yagi Shintaro, Uemoto Shinji

    WORLD JOURNAL OF SURGERY   Vol. 36 ( 7 ) page: 1666 - 1671   2012.7

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    DOI: 10.1007/s00268-012-1529-9

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  73. Standard hepatic vein reconstruction with patch plasty using the native portal vein in adult living donor liver transplantation

    Mori Akira, Kaido Toshimi, Ogura Yasuhiro, Ogawa Kohei, Hata Koichiro, Yagi Shintaro, Yoshizawa Atsushi, Isoda Hiroyoshi, Shibata Toshiya, Uemoto Shinji

    LIVER TRANSPLANTATION   Vol. 18 ( 5 ) page: 602 - 607   2012.5

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    DOI: 10.1002/lt.23387

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  74. Use of Recipient's Left Colic Artery for Arterial Reconstruction During Liver Transplantation in Alagille Syndrome With Vasculopathy: A Case Report

    Shehata Mahmoud Refaat, Yagi Shintaro, Ogura Yasuhiro, Ogawa Kohei, Iida Taku, Mori Akira, Sumiyoshi Shinji, Haga Hironori, Uemoto Shinji

    TRANSPLANTATION   Vol. 93 ( 6 ) page: E20 - E21   2012.3

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  75. Significance of trough monitoring for tacrolimus blood concentration and calcineurin activity in adult patients undergoing primary living-donor liver transplantation

    Yano Ikuko, Masuda Satohiro, Egawa Hiroto, Sugimoto Mitsuhiro, Fukudo Masahide, Yoshida Yuko, Hashi Sachiyo, Yoshizawa Atsushi, Ogura Yasuhiro, Ogawa Kohei, Mori Akira, Kaido Toshimi, Uemoto Shinji, Inui Ken-ichi

    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY   Vol. 68 ( 3 ) page: 259 - 266   2012.3

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    DOI: 10.1007/s00228-011-1129-x

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  76. Left-sided grafts for living-donor liver transplantation and split grafts for deceased-donor liver transplantation: Their impact on long-term survival

    Hori Tomohide, Uemoto Shinji, Gardner Lindsay B., Sibulesky Lena, Ogura Yasuhiro, Nguyen Justin H.

    CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY   Vol. 36 ( 1 ) page: 47 - 52   2012.2

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    DOI: 10.1016/j.clinre.2011.08.008

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  77. Splenectomy Does Not Offer Immunological Benefits in ABO-Incompatible Liver Transplantation With a Preoperative Rituximab

    Raut Vikram, Mori Akira, Kaido Toshimi, Ogura Yasuhiro, Taku Iida, Nagai Kazuyuki, Sasaki Naoya, Endo Kosuke, Hata Toshiyuki, Yagi Shintaro, Egawa Hiroto, Uemoto Shinji

    TRANSPLANTATION   Vol. 93 ( 1 ) page: 99 - 105   2012.1

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    DOI: 10.1097/TP.0b013e318239e8e4

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  78. Effect of maintenance therapy with low-dose peginterferon for recurrent hepatitis C after living donor liver transplantation

    Ueda Y., Marusawa H., Kaido T., Ogura Y., Oike F., Mori A., Ogawa K., Yoshizawa A., Hatano E., Miyagawa-Hayashino A., Haga H., Egawa H., Takada Y., Uemoto S., Chiba T.

    JOURNAL OF VIRAL HEPATITIS   Vol. 19 ( 1 ) page: 32 - 38   2012.1

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    DOI: 10.1111/j.1365-2893.2010.01398.x

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  79. Living donor liver transplantation for recurrent hepatocellular carcinoma after liver resection

    Kaido Toshimi, Mori Akira, Ogura Yasuhiro, Hata Koichiro, Yoshizawa Atsushi, Iida Taku, Yagi Shintaro, Uemoto Shinji

    SURGERY   Vol. 151 ( 1 ) page: 55 - 60   2012.1

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    DOI: 10.1016/j.surg.2011.06.032

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  80. How transplant surgeons can overcome the inevitable insufficiency of allograft size during adult living-donor liver transplantation: strategy for donor safety with a smaller-size graft and excellent recipient results

    Hori Tomohide, Ogura Yasuhiro, Ogawa Kohei, Kaido Toshimi, Segawa Hajime, Okajima Hideaki, Kogure Takayuki, Uemoto Shinji

    CLINICAL TRANSPLANTATION   Vol. 26 ( 3 ) page: E324 - E334   2012

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    DOI: 10.1111/j.1399-0012.2012.01664.x

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  81. Pre- and perioperative factors affecting infection after living donor liver transplantation

    Kaido Toshimi, Mori Akira, Ogura Yasuhiro, Ogawa Kouhei, Hata Koichiro, Yoshizawa Atsushi, Yagi Shintaro, Uemoto Shinji

    NUTRITION   Vol. 28 ( 11-12 ) page: 1104 - 1108   2012

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    DOI: 10.1016/j.nut.2012.02.007

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KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 小児肝移植後持続性高EBウイルス血症の病態及びグラフト肝における線維化機序の解明

    Grant number:17K10509  2017.4 - 2021.3

    亀井 秀弥

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    小児肝移植症例では移植後免疫抑制療法下にEstein-Barr(EB)ウイルスの初感染となることが稀でなく、そのためその後高EBウイルス血症が長期にわたり持続する症例も多い。しかしその病態や臨床的意義、長期予後への影響などは不明である。一方、小児肝移植領域では長期生存が重要とされるが、近年血液検査上肝機能に異常がなくてもグラフト肝の線維化が進行していることが問題視されているがその原因は未だ解明されていない。持続性高EBウイルス血症を認める小児生体肝移植症例についてもウイルス学的・免疫学的な解析を行いその病態を解明するとともに、肝炎を引き起こすことでも知られているEBウイルスがグラフト肝に与える影響を病理組織学的にも検討し解明することを目的としている。肝移植後高EBウイルス血症を引きおこす病態が解明され、その特徴や特異性が同定されればその治療法や予防法も確立することが可能であると予想され、小児肝移植長期予後の向上に大きく貢献するものと考えられる。グラフト肝の評価としては肝線維化マーカーの測定に加えプロトコール肝生検により病理組織学的にも評価し2群間で比較検討する。特にEBウイルス高値群ではEBERsによる染色も行い評価する。当院にて生体肝移植を施行した小児症例に対して、入院中は週1度、外来通院加療中は4-6週間にリアルタイムPCR法を用いた定量法でEBウイルス量を測定している。全血EBV-DNA量が10000IU/ml以上の状態が6ヶ月以上持続した症例をEBV持続高値群とした場合、約4割が持続高値群となっている。現在移植後1年以上経過した症例に対して肝生検を施行している。
    当院にて生体肝移植を施行した小児症例に対して、入院中は週1度、外来通院加療中は4-6週間にリアルタイムPCR法を用いた定量法でEBウイルス量を測定している。全血EBV-DNR量は10000IU/ml以上の状態が6ヶ月以上持続した症例をEBV持続高値群とした場合、約4割が持続高値群となっている。持続性EBV血症へのリスクファクターとして冷阻血時間、移植時EBウイルス未感染などが同定でき、報告もしている。
    肝生検標本に関してはEBV持続高値群の標本に対しEBERs染色を行い、評価している。
    今後も小児生体肝移植患者に対してEBウイルス量を測定していくとともに肝生検を順次行い、評価していく。またEBウイルス血症とグラフト肝の病理組織学的所見、線維化マーカーとの関連性も解析していく。

  2. The analysis of deceased donor split liver transplantation in Japan

    Grant number:25461968  2013.4 - 2016.3

    Sakamoto Seisuke

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    According to the analysis of deceased donor split liver transplantation (SLT),including 36 cases undergoing the operation by the end of 2014, the outcome was satisfactory and compatible with the previously published data. However, the incidence of surgical complications was relatively high, and those complications tended to occur in the patients receiving right-sided split grafts. In terms of the donor criteria for SLT, it would be suitable to use the Western countries' criteria, including donor age (younger than 50 years), liver function tests (within 3 times of the upper normal limits), and less than mild steatosis. Critically-ill patients and retransplant patients have to be avoided as SLT recipient candidates, although it would not be possible to be applied at present owing to the shortage of deceased donor organs. The splitting procedure may be reconsidered to prevent surgical complications and in-situ splitting procedure may be favorable instead of ex-vivo splitting procedure.

  3. Developmemt of novel psychosocial evaluation method in liver transplantation for alcohol liver failure

    Grant number:24591875  2012.4 - 2018.3

    Onishi Yasuharu

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    Authorship:Coinvestigator(s) 

    Recipients' re-drinking in 20-50% after liver transplantation for alcoholic liver failure is a social problem that could negate transplanted organs provided free of donor. Psychosocial evaluation and long-term follow-up from the preoperative point of view are also important worldwide.
    We created psychosocial criteria and compared retrospectively with "candidate for transplant recipients for alcoholic liver failure" and "candidate for other liver transplant recipients" to investigate the comprehensive factors. We have been conducting retrospective examination using psychosocial evaluation criteria established at our hospital, and we have clarified the effectiveness of this evaluation method so far at the conference.

  4. Impact of nitric oxide with oxygen gas persufflation on marginal graft in liver transplantation

    Grant number:24591877  2012.4 - 2015.3

    YAGI Shintaro

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    Authorship:Coinvestigator(s) 

    We established small-for-size graft liver transplantation model in pig, which is 30% partial liver graft volume using right-lateral lobe. We investigated the effect of nitric oxide (NO) gas during liver preservation on small-for-size livers after transplantation. Gaseous oxygen with NO (40 ppm) was insufflated into the livers through the suprahepatic vena cava during cold storage (VSNOP group). Livers in Control group was preserved by simple cold storage.
    One recipients in VSNOP group survived for 7 days, and the survival rates in VSNOP group tended to be better compared with control group. Pressure gradient between portal vein and inferior vena cava of livers preserved by VSNOP tended to be lower compared with the control livers just behind portal reperfusion.

  5. Towards Elucidation of a novel mechanism for Pathogenesis of coagulation and fibrinolysis abnormalities in liver transplantation

    Grant number:23390313  2011.4 - 2014.3

    UEMOTO Shinji

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    Thrombotic microangiopathy (TMA) is one of the life threatening diseases, which characterized by aggregation of platelets in systemic circulation, and therefore multiple organ dysfunction. The purpose of this study is to clarify the clinical characteristics and prognostic factors of TMA after liver transplantation (LTx). A total of 290 LTx patients from April 2006 to March 2013 were evaluated. We elucidated that the ADAMTS13 activity decreased by more than half in all patients and that TMA is an inevitable process after LTx because of cold-ischemia/warm-reperfusion (CI/WR) during graft preservation. Pathological Confirmation revealed that sinusoidal injury after CI/WR activated complement system, thus regulation of complement activation could be the target to improve the early outcome after LTx.

  6. Challenge of extending warm ischemic time in rat liver transplantation from cardiac death donors

    Grant number:22591405  2010.4 - 2013.3

    OGURA Yasuhiro

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    Liver transplant outcomes using grafts donated after cardiac death (DCD) remain poor. Our goal of this study was to extend the warm ischemic time in rat liver transplantation from DCD donors. For this purpose, it is important to control the ischemic/reperfusion (I/R) injury after transplantation. There are a couple of reports to prevent I/R injury, and we applied venous systemic oxygen persufflation (VSOP) and nitric oxide (NO) gas administration.
    Using rat liver transplantation models from 60 minutes DCD donors, VSOP-NO treatment could effectively decreasing the damage of I/R injury, leading to the better survival. However, we failed to extend the warm ischemic time by this methods. There may be a limitation in these graft reconditioning procedures, further investigation to understand this phenomena is required.

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