Faculty Profiles - OGURA Yasuhiro

写真a

OGURA Yasuhiro

Organization

Nagoya University Hospital Transplantation Surgery Professor of hospital

Contact information

Degree 1

博士（医学）（ 2002.7 京都大学）

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Research Interests 1

liver transplantation

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Research Areas 1

Others / Others / 移植外科

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Education 1

Kyoto University Faculty of Medicine

1985.4 - 1991.3

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Country： Japan

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Professional Memberships 7

日本外科学会
日本消化器外科学会
肝胆膵外科学会
日本肝臓学会
日本肝移植研究会
International Liver Transplantation Society
Japanese Society for Histocompatibility and Immunogenetics

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Papers 87

Successful living-donor liver transplantation for sustained liver failure even after resolution of infiltrative massive hepatic invasion of stage 4S neuroblastoma: a case report

Jobara, K; Yamamori, A; Shizuku, M; Kurata, N; Fujimoto, Y; Muramatsu, H; Takahashi, Y; Ogura, Y

SURGICAL CASE REPORTS Vol. 9 ( 1 ) 2023.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s40792-023-01681-0

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PubMed
Recovery From Severe Systemic Peripheral Neuropathy Secondary to Erythropoietic Protoporphyria by Liver Transplant: A Case Report

Shizuku M., Kurata N., Jobara K., Tanaka T., Fukuta A., Hatanaka M., Hara K., Katsuno M., Nakano H., Ogura Y.

Experimental and Clinical Transplantation Vol. 20 ( 10 ) page： 954 - 958 2022.10

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Language：English Publishing type：Research paper (scientific journal) Publisher：Experimental and Clinical Transplantation

Erythropoietic protoporphyria is a rare inherited metabolic disorder involving the heme biosynthesis pathway and leads to the accumulation of protopo-rphyrin in the erythrocytes or liver. Although peripheral neuropathy is known to develop occa-sionally in other types of porphyria, it rarely occurs in patients with erythropoietic protoporphyria. A 16-year-old boy was transferred to our hospital due to end-stage liver disease secondary to erythropoietic protoporphyria. Severe systemic peripheral neuropathy, similar to that presented in Guillain-Barré syndrome, developed; it was promptly managed with mechanical ventilation. Electrophysiological assessment of the presented neuropathy showed no responsiveness, indicating severe axonopathy. Six weeks after the transfer, liver transplant was performed. Postoperatively, hepatorenal syndromes improved immediately, and his erythrocyte protoporphyrin level decreased from 6291 to 174 μg/dL red blood cells. The patient started to move his limbs gradually and was weaned from mechanical ventilation 2 months after liver transplant. Eventually, he was discharged from hospital and was able to ambulate with assistance 10 months after liver transplant. To our knowledge, this is the first report detailing the clinical course in a patient with erythropoietic protoporphyria who recovered from severe systemic peripheral neuropathy after liver transplant.

DOI： 10.6002/ect.2022.0157

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Temporal dynamics of the plasma microbiome in recipients at early post-liver transplantation: a retrospective study

Okumura T., Horiba K., Kamei H., Takeuchi S., Suzuki T., Torii Y., Kawada J.i., Takahashi Y., Ogura Y., Ogi T., Ito Y.

BMC Microbiology Vol. 21 ( 1 ) page： 104 2021.12

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Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Microbiology

Background: Immunosuppression during liver transplantation (LT) enables the prevention and treatment of organ rejection but poses a risk for severe infectious diseases. Immune modulation and antimicrobials affect the plasma microbiome. Thus, determining the impact of immunosuppression on the microbiome may be important to understand immunocompetence, elucidate the source of infection, and predict the risk of infection in LT recipients. We characterized the plasma microbiome of LT recipients at early post-LT and assessed the association between the microbiome and clinical events. Results: In this study, 51 patients who received LT at Nagoya University Hospital from 2016 to 2018 were enrolled. Plasma samples were retrospectively collected at the following time points: 1) within a week after LT; 2) 4 ± 1 weeks after LT; 3) 8 ± 1 weeks after LT; and 4) within 2 days after a positive blood culture. A total of 111 plasma samples were analyzed using shotgun next-generation sequencing (NGS) with the PATHDET pipeline. Relative abundance of Anelloviridae, Nocardiaceae, Microbacteriaceae, and Enterobacteriaceae significantly changed during the postoperative period. Microbiome diversity was higher within a week after LT than that at 8 weeks after LT. Antimicrobials were significantly associated with the microbiome of LT recipients. In addition, the proportion of Enterobacteriaceae was significantly increased and the plasma microbiome diversity was significantly lower in patients with acute cellular rejection (ACR) than non-ACR patients. Sequencing reads of bacteria isolated from blood cultures were predominantly identified by NGS in 8 of 16 samples, and human herpesvirus 6 was detected as a causative pathogen in one recipient with severe clinical condition. Conclusions: The metagenomic NGS technique has great potential in revealing the plasma microbiome and is useful as a comprehensive diagnostic procedure in clinical settings. Temporal dynamics of specific microorganisms may be used as indirect markers for the determination of immunocompetence and ACR in LT recipients.

DOI： 10.1186/s12866-021-02154-w

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Psychosocial characteristics of alcoholic and non-alcoholic liver disease recipient candidates in liver transplantation: a prospective observational study

Shizuku M., Kimura H., Kamei H., Kishi S., Tokura T., Kurata N., Jobara K., Yoshizawa A., Tsuboi C., Yamaguchi N., Kato M., Kawai K., Yamashiki M., Kanai E., Ishizuka K., Ozaki N., Ogura Y.

BMC Gastroenterology Vol. 21 ( 1 ) 2021.12

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Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Gastroenterology

Background: There are long-standing controversies about the transplant indications for alcoholic liver disease (ALD), because of the recognition that ALD is fundamentally self-inflicted. However, it is unclear whether psychosocial characteristics of ALD are different from that of non-alcoholic liver disease (NALD) in the selection of liver transplantation (LT) recipients. We aimed to clarify the psychosocial characteristics of ALD recipients (ALD-R)/ALD recipient candidates (ALD-RC) and NALD recipients (NALD-R)/ NALD recipient candidates (NALD-RC). Methods: From 2011 to 2019, 75 patients were enrolled in this prospective observational study (ALD-RC, n = 19; NALD-RC, n = 56), LT were carried out as follow; ALD-R, n = 6; NALD-R, n = 52. We evaluated psychosocial characteristics in the preoperative period and 3, 12 months after LT (ALD-R, n = 3/3; NALD-R, n = 28/25). The following scales were used to evaluate psychosocial characteristics: Visual Analogue Scale, Alcohol Use Disorders Identification Test, Hospital Anxiety and Depression Scale, Beck Depression Inventory, Brief Evaluation of Medication Influences and Beliefs, Social Support Questionnaire (SSQ), Temperament and Character Inventory, Parental Bonding Instrument (PBI), the Short Form Health Survey (SF-36). Results: When evaluating on the basis of abstinence rule, a comparison of ALD-RC and NALD-RC in the preoperative period identified similar patterns of psychosocial characteristics, except that the NALD-RC scored higher on the PBI item “overprotection from mother” (P < 0.05). The only significant difference between ALD-R and NALD-R after liver transplantation was in SSQ scores at 3 months. Conclusion: The psychosocial characteristics of ALD-RC and NALD-RC may be similar when evaluated on the basis of Japan’s abstinence rule. This result also imply that the psychosocial characteristics of ALD-RC may differ from the previously reported psychosocial characteristics of alcohol dependent patients. These findings have the potential to provide helpful information for the evaluation of ALD-RC.

DOI： 10.1186/s12876-021-02032-9

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The impact of chronic Epstein–Barr virus infection on the liver graft of pediatric liver transplant recipients: A retrospective observational study

Shizuku M., Kamei H., Yoshizawa A., Ito Y., Ogura Y., Yoshikawa J., Kurata N., Jobara K., Kodera Y.

Transplant Infectious Disease Vol. 23 ( 5 ) 2021.10

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Language：English Publishing type：Research paper (scientific journal) Publisher：Transplant Infectious Disease

Background: Chronic high Epstein–Barr virus loads (CHEBV) are commonly observed in pediatric liver transplant patients. However, it is unclear how CHEBV impacts the liver graft. The aim of this study was to clarify the clinical and pathological impacts of CHEBV on the liver graft. Methods: From 2012 to 2020, we retrospectively investigated 46 pediatric liver transplant patients (under 16 years) who survived ≥6 months. The patients were divided into two groups: CHEBV group (EBV DNA >10 000 IU/ml of whole blood for ≥6 months) and nonchronic high EBV (NCHEBV) group (patients who did not meet CHEBV criteria). Tacrolimus was reduced to <3.0 ng/ml in patients with EBV DNA >5000 IU/ml. Blood biochemistry data and pathological findings, obtained at the time of protocol and episodic biopsies, were compared between the two groups. Results: Out of 46 patients, 28 CHEBV and 18 NCHEBV patients were enrolled. The blood biochemical examination did not show a significant difference between the two groups. In addition, no significant differences between the two groups were found in the pathological findings, including frequency of late acute rejection and the progression of fibrosis at the time of both protocol and episodic biopsies. Appropriate adjustment of immunosuppression for CHEBV management may have contributed to the prevention of the progression of fibrosis. Conclusion: CHEBV had little adverse effect on the liver graft. Graft fibrosis might have been avoided through optimal dose modification of tacrolimus. Further long-term monitoring is necessary because CHEBV may affect the pediatric liver graft in the long term.

DOI： 10.1111/tid.13731

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Revisiting prognosis after liver transplant in patients positive for hepatitis c virus: Focus on hepatitis c recurrence-unrelated complications

Ishigami M., Honda T., Ishizu Y., Imai N., Ito T., Yamamoto K., Kamei H., Ogura Y., Fujishiro M.

Experimental and Clinical Transplantation Vol. 19 ( 9 ) page： 935 - 942 2021.9

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Objectives: In this study, we revisited the reasons for poorer prognosis after liver transplant in patients with hepatitis C virus, whose main causes of death were generally known to be recurrent disease. Materials and Methods: Between April 2003 and March 2017, among 132 patients who underwent liver transplant because of liver cirrhosis at our institution, 40 patients (30.3%) were positive for hepatis C virus. We retrospectively compared the overall survival after liver transplant in patients with and without hepatitis C virus infection. Furthermore, we investigated the causes of death in transplant recipients with hepatitis C virus infections. Results: In patients with hepatitis C virus infection, overall survival was 82.2%, 75.2%, and 50.8% at 1, 5, and 10 years, respectively, after liver transplant; these results were lower than those in patients without infection (94.5%, 87.0%, and 87.0% at 1, 5, and 10 years, respectively; P = .001). Among 40 patients with positive infection, 14 patients died after liver transplant. A main reason for death was hepatocellular carcinoma recurrence (3 patients). Surprisingly, only 1 patient died from hepatitis C virus-related complication (fibrosing cholestatic hepatitis); the remaining 10 patients died from reasons other than hepatitis C virus disease progression. Conclusions: Our results suggest that clinicians should not only be aware of hepatitis C virus recurrence but should also be aware of other unrelated complications in transplant recipients who are positive for this virus.

DOI： 10.6002/ect.2021.0197

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Incidental intrahepatic cholangiocarcinoma in patients undergoing liver transplantation: A multi-center study in Japan.

Hara T, Eguchi S, Yoshizumi T, Akamatsu N, Kaido T, Hamada T, Takamura H, Shimamura T, Umeda Y, Shinoda M, Ogura Y, Fukumoto T, Kasahara M, Hibi T, Umeshita K, Furukawa H, Ohdan H

Journal of hepato-biliary-pancreatic sciences Vol. 28 ( 4 ) page： 346 - 352 2021.4

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Publishing type：Research paper (scientific journal)

DOI： 10.1002/jhbp.896

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A novel anatomic variation of the intrahepatic biliary tree in live liver donor surgery: A case report

Shizuku Masato, Kurata Nobuhiko, Jobara Kanta, Yoshizawa Atsushi, Ogura Yasuhiro

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS Vol. 79 page： 231 - 233 2021

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Publishing type：Research paper (scientific journal) Publisher：International Journal of Surgery Case Reports

DOI： 10.1016/j.ijscr.2021.01.042

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De novo hepatocellular carcinoma in living donor liver grafts: A Japanese multicenter experience.

Goto R, Kosai-Fujimoto Y, Yagi S, Kobayashi T, Akamatsu N, Shimamura T, Imura S, Ogiso S, Mizuno S, Takatsuki M, Fukuhara T, Kanto T, Eguchi S, Yanaga K, Ogura Y, Fukumoto T, Shimada M, Hasegawa K, Ohdan H, Uemoto S, Soejima Y, Ikegami T, Yoshizumi T, Taketomi A, Maehara Y

Hepatology research : the official journal of the Japan Society of Hepatology Vol. 50 ( 12 ) page： 1365 - 1374 2020.12

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Publishing type：Research paper (scientific journal) Publisher：Hepatology Research

DOI： 10.1111/hepr.13565

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The role of living donor liver transplantation for acute liver failure

Ogura, Y; Kabacam, G; Singhal, A; Moon, DB

INTERNATIONAL JOURNAL OF SURGERY Vol. 82 page： 145 - 148 2020.10

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Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Surgery

Acute liver failure (ALF) is a life-threatening illness that occurs in the absence of pre-existing liver disease. When symptoms seriously progress under continuous supportive medical care, liver transplantation becomes the only therapeutic strategy. However, the available sources of organs for liver transplantation differ worldwide. In regions in which organs from cadaveric donors are more common, deceased donor liver transplantation (DDLT) is performed in this urgent situation. Conversely, in countries where cadaveric donors are scarce, living donor liver transplantation (LDLT) is the only choice. Special considerations must be made for urgent LDLT for ALF, including the expedited evaluation of living donors, technical issues, and the limitations of ABO blood type combinations between recipients and donor candidates. In this review, we highlight the role of LDLT for ALF and the considerations that distinguish it from DDLT. LDLT is well-established as a life-saving procedure for ALF patients and there is often no alternative to LDLT, especially in countries where DDLT is not feasible. However, from a global perspective, an increase in the deceased donor pool might be an urgent and important necessity.

DOI： 10.1016/j.ijsu.2020.04.058

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Revisiting the indications for liver transplantation in cirrhotic patients considering the long-term outcomes of cirrhotic patients

Ishigami M., Honda T., Kuzuya T., Ishizu Y., Ito T., Kamei H., Ogura Y., Fujishiro M.

Journal of Hepato-Biliary-Pancreatic Sciences Vol. 27 ( 9 ) page： 655 - 662 2020.9

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Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Hepato-Biliary-Pancreatic Sciences

Background: In this study, we investigated long-term survival of cirrhotic patients without hepatocellular carcinoma (HCC) and the proper timing of liver transplantation in the era with recent progress of management. Methods: We first classified 217 non-transplant cirrhotic patients without HCC according to the long-term survival based on Child-Turcotte-Pugh (CTP) scores and the MELD scores. We then compared them with the survival after liver transplantation in 114 patients with liver cirrhosis. Results: We classified into four groups (class A as CTP score of 5,6, B as 7,8, C as 9-12, D as 13-15) according to the long-term survival of the patients, the survivals of patients with class C and D were significantly worse compared with transplant patients (P < 0.001 in each group). And we also classified into four groups based on the MELD scores (class A as MELD score of −8, B as 9-12, C as 13-19, D as 19-), the survivals of patients with class C and D were significantly worse compared with those of transplant patients (P < 0.001 in each group). Conclusions: Considering the long-term survival of patients with liver cirrhosis, CTP score of 9 and/or MELD score of 13 could be a proper timing for liver transplantation.

DOI： 10.1002/jhbp.777

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Portal Vein Stenosis Following Liver Transplantation Hemodynamically Assessed with 4D-flow MRI before and after Portal Vein Stenting.

Hyodo R, Takehara Y, Mizuno T, Ichikawa K, Ogura Y, Naganawa S

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2020.8

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Publishing type：Research paper (scientific journal)

DOI： 10.2463/mrms.ici.2020-0057

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Laparoscopic Kasai portoenterostomy is advantageous over open Kasai portoenterostomy in subsequent liver transplantation

Shirota Chiyoe, Murase Naruhiko, Tanaka Yujiro, Ogura Yasuhiro, Nakatochi Masahiro, Kamei Hideya, Kurata Nobuhiko, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Uchida Hiroo

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES Vol. 34 ( 8 ) page： 3375 - 3381 2020.8

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Publishing type：Research paper (scientific journal) Publisher：Surgical Endoscopy

DOI： 10.1007/s00464-019-07108-y

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Computational Fluid Dynamics-Based Blood Flow Assessment Facilitates Optimal Management of Portal Vein Stenosis After Liver Transplantation

Ogiso Satoshi, Nakamura Masanori, Tanaka Takashi, Komiya Kenji, Kamei Hideya, Onishi Yasuharu, Jobara Kanta, Kurata Nobuhiko, Itatani Keiichi, Ogura Yasuhiro

JOURNAL OF GASTROINTESTINAL SURGERY Vol. 24 ( 2 ) page： 460 - 461 2020.2

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Publishing type：Research paper (scientific journal) Publisher：Journal of Gastrointestinal Surgery

DOI： 10.1007/s11605-019-04279-w

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Clinical Features and Long-Term Outcomes of Living Donors of Liver Transplantation Who Developed Psychiatric Disorders

Shizuku Masato, Kamei Hideya, Kimura Hiroyuki, Kurata Nobuhiko, Jobara Kanta, Yoshizawa Atsushi, Ishizuka Kanako, Okada Aoi, Kishi Shinichi, Ozaki Norio, Ogura Yasuhiro

ANNALS OF TRANSPLANTATION Vol. 25 page： e918500 2020.1

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Publishing type：Research paper (scientific journal) Publisher：Annals of Transplantation

DOI： 10.12659/AOT.918500

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Decreased long-term graft survival in persistent biliary complications after right-lobe living-donor liver transplantation

Ogiso Satoshi, Kamei Hideya, Onishi Yasuharu, Kurata Nobuhiko, Jobara Kanta, Kawashima Hiroki, Ogura Yasuhiro

CLINICAL TRANSPLANTATION Vol. 34 ( 1 ) page： e13771 2020.1

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Publishing type：Research paper (scientific journal) Publisher：Clinical Transplantation

DOI： 10.1111/ctr.13771

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Budd-Chiari Syndrome Associated With Hypereosinophilic Syndrome Treated by Deceased-Donor Liver Transplantation: A Case Report

Shizuku Masato, Kurata Nobuhiko, Jobara Kanta, Yoshizawa Atsushi, Kamei Hideya, Amano Nozomi, Genda Takuya, Ogura Yasuhiro

TRANSPLANTATION PROCEEDINGS Vol. 51 ( 9 ) page： 3140 - 3146 2019.11

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Publishing type：Research paper (scientific journal) Publisher：Transplantation Proceedings

DOI： 10.1016/j.transproceed.2019.08.003

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Splenectomy in living donor liver transplantation and risk factors of portal vein thrombosis

Kurata, N; Ogura, Y; Ogiso, S; Onishi, Y; Kamei, H; Kodera, Y

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL Vol. 18 ( 4 ) page： 337 - 342 2019.8

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Language：English Publishing type：Research paper (scientific journal) Publisher：Hepatobiliary and Pancreatic Diseases International

Background: Graft inflow modulation (GIM) during adult-to-adult living donor liver transplantation (LDLT) is a common strategy to avoid small-for-size syndrome, and some transplant surgeons attempt small size graft strategy with frequent GIM procedures, which are mostly performed by splenectomy, in LDLT. However, splenectomy can cause serious complications such as portal vein thrombosis and overwhelming postsplenectomy infection. Methods: Forty-eight adult-to-adult LDLT recipients were enrolled in this study and retrospectively reviewed. We applied the graft selection criteria, which routinely fulfill graft-to-recipient weight ratio ≥ 0.8%, and consider GIM as a backup strategy for high portal venous pressure (PVP). Results: In our current strategy of LDLT, splenectomy was performed mostly due to hepatitis C and splenic arterial aneurysms, but splenectomy for GIM was intended to only one patient (2.1%). The final PVP values ≤ 20 mmHg were achieved in all recipients, and no significant difference was observed in patient survival or postoperative clinical course based on whether splenectomy was performed or not. However, 6 of 18 patients with splenectomy (33.3%) developed postsplenectomy portal vein thrombosis (PVT), while none of the 30 patients without splenectomy developed PVT after LDLT. Splenectomy was identified as a risk factor of PVT in this study (P < 0.001). Our study revealed that a lower final PVP could be risk factor of postsplenectomy PVT. Conclusions: Using sufficient size grafts was one of the direct solutions to control PVP, and allowed GIM to be reserved as a backup procedure. Splenectomy should be avoided as much as possible during LDLT because splenectomy was found to be a definite risk factor of PVT. In splenectomy cases with a lower final PVP, a close follow-up is required for early detection and treatment of PVT.

DOI： 10.1016/j.hbpd.2019.06.011

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Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial

Kaido Toshimi, Shinoda Masahiro, Inomata Yukihiro, Yagi Takahito, Akamatsu Nobuhisa, Takada Yasutsugu, Ohdan Hideki, Shimamura Tsuyoshi, Ogura Yasuhiro, Eguchi Susumu, Eguchi Hidetoshi, Ogata Satoshi, Yoshizumi Tomoharu, Ikegami Toshihiko, Yamamoto Michio, Morita Satoshi, Uemoto Shinji

NUTRITION Vol. 54 page： 68 - 75 2018.10

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DOI： 10.1016/j.nut.2018.02.022

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Risk factors and long-term outcomes of pediatric liver transplant recipients with chronic high Epstein-Barr virus loads

Kamei Hideya, Ito Yoshinori, Kawada Junichi, Ogiso Satoshi, Onishi Yasuharu, Komagome Masahiko, Kurata Nobuhiko, Ogura Yasuhiro

TRANSPLANT INFECTIOUS DISEASE Vol. 20 ( 4 ) page： e12911 2018.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/tid.12911

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Diagnostic Usefulness of APRI and FIB-4 for the Prediction of Liver Fibrosis After Liver Transplantation in Patients Infected with Hepatitis C Virus

Imai H., Kamei H., Onishi Y., Ishizu Y., Ishigami M., Goto H., Ogura Y.

TRANSPLANTATION PROCEEDINGS Vol. 50 ( 5 ) page： 1431 - 1436 2018.6

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DOI： 10.1016/j.transproceed.2018.03.005

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Lung Metastases from Bile Duct Adenocarcinoma Mimicking Chronic Airway Infection and Causing Diagnostic Difficulty.

Sato M, Okachi S, Fukihara J, Shimoyama Y, Wakahara K, Sakakibara T, Hase T, Onishi Y, Ogura Y, Maeda O, Hasegawa Y

Internal medicine (Tokyo, Japan) Vol. 57 ( 10 ) page： 1429 - 1432 2018

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DOI： 10.2169/internalmedicine.9718-17

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Brain death organ donor supported by a left ventricular assist device showing unexpected congestive liver fibrosis: A case report

Kamei Hideya, Komagome Masahiko, Kurata Nobuhiko, Ogiso Satoshi, Onishi Yasuharu, Hara Takanobu, Takatsuki Mitsuhisa, Eguchi Susumu, Ogura Yasuhiro

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS Vol. 47 page： 57-60 2018

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DOI： 10.1016/j.ijscr.2018.04.026

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Successful Post-Transplant Psychiatric Interventions During Long-Term Follow-Up of Patients Receiving Liver Transplants for Alcoholic Liver Disease.

Kimura H, Onishi Y, Kishi S, Kurata N, Ogiso S, Kamei H, Tsuboi C, Yamaguchi N, Shiga A, Kondo M, Yokoyama Y, Takasato F, Fujishiro H, Ishizuka K, Okada T, Ogura Y, Ozaki N

The American journal of case reports Vol. 18 page： 1215 - 1219 2017.11

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DOI： 10.12659/AJCR.906446

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A MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF EXTRACT OF JAPANESE HERBAL MEDICINE DAIKENCHUTO TO PREVENT BOWEL DYSFUNCTION AFTER ADULT LIVER TRANSPLANTATION (DKB 14 STUDY)

Sugawara Yasuhiko, Kaido Toshimi, Shinoda Masahiro, Inomata Yukihoro, Yagi Takahito, Akamatsu Nobuhisa, Takada Yasutsugu, Ohdan Hideki, Shimamura Tsuyoshi, Ogura Yasuhiiro, Eguchi Susumu, Eguchi Hidetoshi, Yamamoto Masakazu, Maehara Yoshihiko, Miyagawa Shinichi, Uemoto Shinji

TRANSPLANT INTERNATIONAL Vol. 30 page： 351-351 2017.9

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SUCCESSFUL SERIES OF RITUXIMAB DESENSITIZATION FOR LIVER TRANSPLANTATION WITH PREFORMED DONOR SPECIFIC ANTIBODIES

Ogura Yasuhiro, Kamei Hideya, Komagome Masahiko, Kurata Nobuhiko, Onishi Yasuharu

TRANSPLANT INTERNATIONAL Vol. 30 page： 57-57 2017.9

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Successful Blood Transfusion Management of a Living Donor Liver Transplant Recipient in the Presence of Anti-Jr(a): A Case Report

Kurata N., Onishi Y., Kamei H., Hori T., Komagome M., Kato C., Matsushita T., Ogura Y.

TRANSPLANTATION PROCEEDINGS Vol. 49 ( 7 ) page： 1604 - 1607 2017.9

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DOI： 10.1016/j.transproceed.2017.06.009

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Donor Selection and Prophylactic Strategy for Venous Thromboembolic Events in Living Donors of Liver Transplantation Based on Results of Thrombophilia Screening Tests

Kamei Hideya, Onishi Yasuharu, Kurata Nobuhiko, Ishigami Masatoshi, Ogura Yasuhiro

ANNALS OF TRANSPLANTATION Vol. 22 page： 409-416 2017.7

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DOI： 10.12659/AOT.902791

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Donor Selection and Prophylactic Strategy for Venous Thromboembolic Events in Living Donors of Liver Transplantation Based on Results of Thrombophilia Screening Tests.

Kamei H, Onishi Y, Kurata N, Ishigami M, Ogura Y

Annals of transplantation Vol. 22 page： 409-416 2017.7

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Chronic High Epstein-Bar Virus Loads in Pediatric Liver Transplant Recipients - Risk Factors and Long-term Outcomes

Kamei H., Ito Y., Ohnishi Y., Kawada J., Kurata N., Komagome M., Ogura Y.

TRANSPLANTATION Vol. 101 ( 5 ) page： 83-83 2017.5

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A Multicenter, Randomized, Placebo-controlled Trial of Extract of Japanese Herbal Medicine Daikenchuto to Prevent Bowel Dysfunction after Adult Liver Transplantation (DKB 14 Study)

Mizota T., Kaido T., Shinoda M., Hibi T., Inomata Y., Yagi T., Akamatsu N., Takada Y., Ohdan H., Shimamura T., Ogura Y., Eguchi S., Eguchi H., Yamamoto M., Maehara Y., Miyagawa S., Uemoto S.

TRANSPLANTATION Vol. 101 ( 5 ) page： 157-158 2017.5

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Rituximab Desensitization for Liver Transplantaiton with Preformed Donor Specific Antibodies

Ogura Y., Kamei H., Komagome M., Kurata N., Onishi Y.

TRANSPLANTATION Vol. 101 ( 5 ) page： 206-207 2017.5

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Risk of alcohol use relapse after liver transplantation for alcoholic liver disease

Onishi Yasuharu, Kimura Hiroyuki, Hori Tomohide, Kishi Shinichi, Kamei Hideya, Kurata Nobuhiko, Tsuboi Chisato, Yamaguchi Naoko, Takahashi Mayu, Sunada Saki, Hirano Mitsuaki, Fujishiro Hiroshige, Okada Takashi, Ishigami Masatoshi, Goto Hidemi, Ozaki Norio, Ogura Yasuhiro

WORLD JOURNAL OF GASTROENTEROLOGY Vol. 23 ( 5 ) page： 869 - 875 2017.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3748/wjg.v23.i5.869

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Changes in Muscle Strength and Six-Minute Walk Distance Before and After Living Donor Liver Transplantation

Mizuno Y., Ito S., Hattori K., Nagaya M., Inoue T., Nishida Y., Onishi Y., Kamei H., Kurata N., Hasegawa Y., Ogura Y.

TRANSPLANTATION PROCEEDINGS Vol. 48 ( 10 ) page： 3348 - 3355 2016.12

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Publishing type：Research paper (scientific journal) Publisher：Transplantation Proceedings

DOI： 10.1016/j.transproceed.2016.08.042

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Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation

Hori T., Ogura Y., Onishi Y., Kamei H., Kurata N., Kainuma M., Takahashi H., Suzuki S., Ichikawa T., Mizuno S., Aoyama T., Ishida Y., Hirai T., Hayashi T., Hasegawa K., Takeichi H., Ota A., Kodera Y., Sugimoto H., Iida T., Yagi S., Taniguchi K., Uemoto S.

World Journal of Hepatology Vol. 8 ( 25 ) page： 1047 - 1060 2016.9

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Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation (LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow (PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green (ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant (k ICG) in the well-preserved allograft. The k ICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT.

DOI： 10.4254/wjh.v8.i25.1047

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Fibrosing Cholestatic Hepatitis in a Complicated Case of an Adult Recipient After Liver Transplantation: Diagnostic Findings and Therapeutic Dilemma

Hori Tomohide, Onishi Yasuharu, Kamei Hideya, Kurata Nobuhiko, Ishigami Masatoshi, Ishizu Yoji, Ogura Yasuhiro

AMERICAN JOURNAL OF CASE REPORTS Vol. 17 page： 597 - 604 2016.8

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DOI： 10.12659/AJCR.898427

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Early Conversion From Twice-Daily Tacrolimus to Prolonged-Release Tacrolimus in Liver Transplantation: A Single-Center Experience

Ogura Yasuhiro, Imai Hisashi, Kamei Hideya, Hori Tomohide, Kurata Nobuhiko, Onishi Yasuharu

ANNALS OF TRANSPLANTATION Vol. 21 page： 448 - 55 2016.7

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Publishing type：Research paper (scientific journal) Publisher：Annals of Transplantation

DOI： 10.12659/AOT.898604

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How far can we lower graft-to-recipient weight ratio for living donor liver transplantation under modulation of portal venous pressure?

Uemura Tadahiro, Wada Seidai, Kaido Toshimi, Mori Akira, Ogura Yasuhiro, Yagi Shintaro, Fujimoto Yasuhiro, Ogawa Kohei, Hata Koichiro, Yoshizawa Atsushi, Okajima Hideaki, Uemoto Shinji

SURGERY Vol. 159 ( 6 ) page： 1623 - 1630 2016.6

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DOI： 10.1016/j.surg.2016.01.009

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Outcomes of Living Donor Liver Transplantation Alone for Patients on Maintenance Renal Replacement Therapy in Japan: Results of a Nationwide Survey.

Eguchi S, Furukawa H, Uemoto S, Umeshita K, Imamura H, Soyama A, Shimamura T, Isaji S, Ogura Y, Egawa H, Kawachi S, Kasahara M, Nagano H, Ku Y, Ohdan H, Maehara Y, Sato S, Inomata Y

Transplantation direct Vol. 2 ( 6 ) page： e74 2016.6

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DOI： 10.1097/TXD.0000000000000587

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Impact of human T-cell leukemia virus type 1 on living donor liver transplantation: a multi-center study in Japan

Yoshizumi Tomoharu, Takada Yasutsugu, Shirabe Ken, Kaido Toshimi, Hidaka Masaaki, Honda Masaki, Ito Takashi, Shinoda Masahiro, Ohdan Hideki, Kawagishi Naoki, Sugawara Yasuhiko, Ogura Yasuhiro, Kasahara Mureo, Kubo Shoji, Taketomi Akinobu, Yamashita Natsumi, Uemoto Shinji, Yamaue Hiroki, Miyazaki Masaru, Takada Tadahiro, Maehara Yoshihiko

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES Vol. 23 ( 6 ) page： 333 - 341 2016.6

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DOI： 10.1002/jhbp.345

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Cytomegalovirus (CMV) Monitoring After Liver Transplantation: Comparison of CMV Pp65 Antigenemia Assay with Real-Time PCR Calibrated to WHO International Standard.

Kamei H, Ito Y, Onishi Y, Suzuki M, Imai H, Kurata N, Hori T, Tainaka T, Uchida H, Ogura Y

Annals of transplantation Vol. 21 page： 131 - 6 2016.3

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DOI： 10.12659/aot.895677

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Living Donor Liver Transplantation Using a Liver Graft With Congenital Intrahepatic Portosystemic Shunt

Kamei Hideya, Imai Hisashi, Onishi Yasuharu, Sugimoto Hiroyuki, Suzuki Kojiro, Ogura Yasuhiro

TRANSPLANTATION DIRECT Vol. 2 ( 1 ) page： e46 2016.1

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DOI： 10.1097/TXD.0000000000000562

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Development of extensive inferior vena cava thrombosis due to the ligation of a large mesenteric-caval shunt during liver transplantation: A case report

Kamei Hideya, Onishi Yasuharu, Ishigami Masatoshi, Ishizu Yoji, Suzuki Kojiro, Ogura Yasuhiro

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS Vol. 29 page： 211 - 214 2016

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Publishing type：Research paper (scientific journal) Publisher：International Journal of Surgery Case Reports

DOI： 10.1016/j.ijscr.2016.11.012

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Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantation

Hori Tomohide, Onishi Yasuharu, Kamei Hideya, Kurata Nobuhiko, Ishigami Masatoshi, Ishizu Yoji, Ogura Yasuhiro

ANNALS OF GASTROENTEROLOGY Vol. 29 ( 4 ) page： 454 - 459 2016

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Publishing type：Research paper (scientific journal) Publisher：Annals of Gastroenterology

DOI： 10.20524/aog.2016.0069

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Current status of deceased donor split liver transplantation in Japan

Sakamoto Seisuke, Kasahara Mureo, Ogura Yasuhiro, Inomata Yukihiro, Uemoto Shinji

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES Vol. 22 ( 12 ) page： 837 - 845 2015.12

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Publishing type：Research paper (scientific journal) Publisher：Journal of Hepato-Biliary-Pancreatic Sciences

DOI： 10.1002/jhbp.292

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Successful Living-Donor Liver Transplantation for Cholestatic Liver Failure Induced by Allopurinol: Case Report

Imai, H; Kamei, H; Onishi, Y; Yamada, K; Ishizu, Y; Ishigami, M; Goto, H; Ogura, Y

TRANSPLANTATION PROCEEDINGS Vol. 47 ( 9 ) page： 2778 - 2781 2015.11

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A 39-year-old man was diagnosed with allopurinol-induced hepatic injury. He did not show any sign of hepatic encephalopathy, but his serum total bilirubin level was >40 mg/dL when he visited the local hospital. The therapeutic effects of initial medical treatments were transient, and both renal function and coagulation ability were gradually deteriorated. Four months after the onset of hepatic injury, he was referred to our hospital for the purpose of liver transplantation (LT). Although he was wasting and severely jaundiced, his consciousness level was not disturbed at all, with normal serum ammonia blood concentration before LT. Owing to allopurinol-induced severe cholestatic liver failure, living-donor LT (LDLT) was performed with the use of a right lobe graft from his younger brother. The explanted liver was extremely enlarged, with a weight of 2,480 g, and severely cholestatic. Microscopic findings were also compatible with drug-induced cholestatic liver injury. He was discharged from hospital 55 days after LDLT, whereas his renal dysfunction remained at 6 months after LT. There are 3 types of pathophysiology of drug-induced hepatotoxicity: hepatocellular, cholestatic, and mixed liver injury. Although allopurinol hepatotoxicity is rare, it can be severe and even fatal. This is the 1st case report of successful LDLT for a patient who had developed allopurinol-induced cholestatic liver failure.

DOI： 10.1016/j.transproceed.2015.09.038

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Considerable Risk of Restenosis After Endoscopic Treatment for Hepaticojejunostomy Stricture After Living-Donor Liver Transplantation

Kamei H., Imai H., Onishi Y., Ishihara M., Nakamura M., Kawashima H., Ishigami M., Ito A., Ohmiya N., Hirooka Y., Goto H., Ogura Y.

TRANSPLANTATION PROCEEDINGS Vol. 47 ( 8 ) page： 2493 - 2498 2015.10

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DOI： 10.1016/j.transproceed.2015.09.015

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Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation

Ishigami Masatoshi, Ogura Yasuhiro, Hirooka Yoshiki, Goto Hidemi

WORLD JOURNAL OF GASTROENTEROLOGY Vol. 21 ( 36 ) page： 10290 - 10298 2015.9

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Publishing type：Research paper (scientific journal) Publisher：World Journal of Gastroenterology

DOI： 10.3748/wjg.v21.i36.10290

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Changes in Surgical Site Infections after Living Donor Liver Transplantation

Yamamoto Masaki, Takakura Shunji, Iinuma Yoshitsugu, Hotta Go, Matsumura Yasufumi, Matsushima Aki, Nagao Miki, Ogawa Kohei, Fujimoto Yasuhiro, Mori Akira, Ogura Yasuhiro, Kaido Toshimi, Uemoto Shinji, Ichiyama Satoshi

PLOS ONE Vol. 10 ( 8 ) page： e0136559 2015.8

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Publishing type：Research paper (scientific journal) Publisher：PLoS ONE

DOI： 10.1371/journal.pone.0136559

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Liver Transplantation for Non-B and Non-C Hepatocellular Carcinoma.

Kaido T, Mori A, Ogura Y, Hata K, Yoshizawa A, lida T, Yagi S, Uemoto S

Hepato-gastroenterology Vol. 62 ( 140 ) page： 933 - 6 2015.6

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Liver Transplantation in Adults with Acute Liver Failure: A Single Center Experience over A Period of 15 Years.

Kaido T, Ogawa K, Ogura Y, Hata K, Yoshizawa A, Yagi S, Ito T, Uemoto S

Hepato-gastroenterology Vol. 62 ( 140 ) page： 937 - 41 2015.6

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Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients

Kawano Yoshihiko, Suzuki Michio, Kawada Jun-ichi, Kimura Hiroshi, Kamei Hideya, Ohnishi Yasuharu, Ono Yasuyuki, Uchida Hiroo, Ogura Yasuhiro, Ito Yoshinori

VACCINE Vol. 33 ( 12 ) page： 1440 - 1445 2015.3

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Publishing type：Research paper (scientific journal) Publisher：Vaccine

DOI： 10.1016/j.vaccine.2015.01.075

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Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans

Fujii Yukiko, Niisoe Tamon, Harada Kouji H., Uemoto Shinji, Ogura Yasuhiro, Takenaka Katsunobu, Koizum Akio

JOURNAL OF OCCUPATIONAL HEALTH Vol. 57 ( 1 ) page： 1 - 12 2015.1

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Successful adult-to-adult living donor liver transplantation using liver allograft after the resection of hemangioma: A suggestive case for a further expansion of living donor pool

Onishi Y., Kamei H., Imai H., Kurata N., Hori T., Ogura Y.

International Journal of Surgery Case Reports Vol. 16 page： 166 - 170 2015

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Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Surgery Case Reports

Introduction Hepatic hemangioma is one of the most common benign liver tumors. There are few published reports regarding liver transplantation using liver allografts with hemangioma. Presentation of case A 45-year-old man was evaluated as a living donor for 19-year-old son with cirrhosis due to hepatic fibrosis. Preoperative investigations revealed 20 and 7 mm hemangiomas, at segment 2 (S2) and 4 (S4) respectively. Considering the anatomical relation of S2 hemangioma and Glisson 2, liver graft was designed as left lobe excluded S2 hemangioma by partial resection. Estimated graft recipient weight ratio (GRWR) even after partial resection of hemangioma was reasonable. During the donor operation, a partial hepatic resection of S2 hemangioma was performed. Intraoperative pathologic findings revealed a cavernous hemangioma, and then, the left hepatic graft with the caudate lobe was harvested. Actual GRWR was 0.90%. Donor's postoperative course was uneventful. Recipient's post-operative course was almost uneventful. Postoperative computed tomography of the recipient showed the graft regeneration without increase or recurrence of hemangioma. Discussion Organ shortage is a major concern in the field of liver transplantation. A novel donor source with a further option is extremely crucial for a guarantee of liver transplantation. We experienced the first case of adult-to-adult living donor liver transplantation using liver allograft after the resection of hemangioma. Conclusion We advocate that the use of liver allograft with hemangiomas in adult-to-adult LDLT settings can be remarkable strategy to reduce the problem of organ shortage without any unfavorable consequences in both living donor and recipient.

DOI： 10.1016/j.ijscr.2015.09.043

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Postoperative Psychiatric Complications in Living Liver Donors

Kimura H., Onishi Y., Sunada S., Kish S., Suzuki N., Tsuboi C., Yannaguchi N., Imai H., Kamei H., Fujisiro H., Okada T., Ishigami M., Ogura Y., Kiuchi T., Ozaki N.

TRANSPLANTATION PROCEEDINGS Vol. 47 ( 6 ) page： 1860 - 1865 2015

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Publishing type：Research paper (scientific journal) Publisher：Transplantation Proceedings

DOI： 10.1016/j.transproceed.2015.06.021

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Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans.

Fujii Y, Niisoe T, Harada KH, Uemoto S, Ogura Y, Takenaka K, Koizumi A

Journal of occupational health Vol. 57 ( 1 ) page： 1 - 12 2015

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Publishing type：Research paper (scientific journal) Publisher：Journal of Occupational Health

DOI： 10.1539/joh.14-0136-OA

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Impact of preoperative uncontrollable hepatic hydrothorax and massive ascites in adult liver transplantation

Endo Kosuke, Iida Taku, Yagi Shintaro, Yoshizawa Atsushi, Fujimoto Yasuhiro, Ogawa Kohei, Ogura Yasuhiro, Mori Akira, Kaido Toshimi, Uemoto Shinji

SURGERY TODAY Vol. 44 ( 12 ) page： 2293 - 2299 2014.12

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DOI： 10.1007/s00595-014-0839-y

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Urinary Neutrophil Gelatinase-Associated Lipocalin: A Useful Biomarker for Tacrolimus-Induced Acute Kidney Injury in Liver Transplant Patients

Tsuchimoto, A; Shinke, H; Uesugi, M; Kikuchi, M; Hashimoto, E; Sato, T; Ogura, Y; Hata, K; Fujimoto, Y; Kaido, T; Kishimoto, J; Yanagita, M; Matsubara, K; Uemoto, S; Masuda, S

PLOS ONE Vol. 9 ( 10 ) page： e110527 2014.10

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Tacrolimus is widely used as an immunosuppressant in liver transplantation, and tacrolimus-induced acute kidney injury (AKI) is a serious complication of liver transplantation. For early detection of AKI, various urinary biomarkers such as monocyte chemotactic protein-1, liver-type fatty acid-binding protein, interleukin-18, osteopontin, cystatin C, clusterin and neutrophil gelatinase-associated lipocalin (NGAL) have been identified. Here, we attempt to identify urinary biomarkers for the early detection of tacrolimus-induced AKI in liver transplant patients. Urine samples were collected from 31 patients after living-donor liver transplantation (LDLT). Twenty recipients developed tacrolimus-induced AKI. After the initiation of tacrolimus therapy, urine samples were collected on postoperative days 7, 14, and 21. In patients who experienced AKI during postoperative day 21, additional spot urine samples were collected on postoperative days 28, 35, 42, 49, and 58. The 8 healthy volunteers, whose renal and liver functions were normal, were asked to collect their blood and spot urine samples. The urinary levels of NGAL, monocyte chemotactic protein-1 and liver-type fatty acid-binding protein were significantly higher in patients with AKI than in those without, while those of interleukin-18, osteopontin, cystatin C and clusterin did not differ between the 2 groups. The area under the receiver operating characteristics curve of urinary NGAL was 0.876 (95% confidence interval, 0.800-0.951; P<0.0001), which was better than those of the other six urinary biomarkers. In addition, the urinary levels of NGAL at postoperative day 1 (p= 0.0446) and day 7 (p=0.0006) can be a good predictive marker for tacrolimus-induced AKI within next 6 days, respectively. In conclusion, urinary NGAL is a sensitive biomarker for tacrolimus-induced AKI, and may help predict renal event caused by tacrolimus therapy in liver transplant patients.

DOI： 10.1371/journal.pone.0110527

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Frequent Incidence of Escape Mutants After Successful Hepatitis B Vaccine Response and Stopping of Nucleos(t)ide Analogues in Liver Transplant Recipients

Ishigami Masatoshi, Honda Takashi, Ishizu Yoji, Onishi Yasuharu, Kamei Hideya, Hayashi Kazuhiko, Ogura Yasuhiro, Hirooka Yoshiki, Goto Hidemi

LIVER TRANSPLANTATION Vol. 20 ( 10 ) page： 1211 - 1220 2014.10

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Publishing type：Research paper (scientific journal) Publisher：Liver Transplantation

DOI： 10.1002/lt.23935

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Plasma cell hepatitis induced by the termination of antiviral therapy for recurrent hepatitis C after living donor liver transplantation

Ueda Yoshihide, Yoshizawa Atsushi, Ogura Yasuhiro, Miyagawa-Hayashino Aya, Haga Hironori, Chiba Tsutomu, Uemoto Shinji

HEPATOLOGY RESEARCH Vol. 44 ( 10 ) page： E279 - E283 2014.10

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DOI： 10.1111/hepr.12243

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Hepatic arterial complications in adult living donor liver transplant recipients: a single-center experience of 673 cases

Iida T., Kaido T., Yagi S., Hori T., Uchida Y., Jobara K., Tanaka H., Sakamoto S., Kasahara M., Ogawa K., Ogura Y., Mori A., Uemoto S.

CLINICAL TRANSPLANTATION Vol. 28 ( 9 ) page： 1025 - 1030 2014.9

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DOI： 10.1111/ctr.12412

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Living Donor Liver Transplantation Using a Right Liver Graft With Additional Vein Reconstructions for Patient With Situs Inversus

Kamei H., Onishi Y., Ogawa K., Uemoto S., Ogura Y.

AMERICAN JOURNAL OF TRANSPLANTATION Vol. 14 ( 6 ) page： 1453 - 1458 2014.6

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Publishing type：Research paper (scientific journal) Publisher：American Journal of Transplantation

DOI： 10.1111/ajt.12692

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SECTION 7. A NEW THERAPEUTIC STRATEGY ON PORTAL FLOW MODULATION THAT INCREASES DONOR SAFETY WITH GOOD RECIPIENT OUTCOMES

Kaido, T; Ogawa, K; Fujimoto, Y; Ito, T; Tomiyama, K; Mori, A; Ogura, Y; Uemoto, S

TRANSPLANTATION Vol. 97 ( 8 ) page： S30 - S32 2014.4

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DOI： 10.1097/01.tp.0000446271.28557.e8

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Section 7. A new therapeutic strategy on portal flow modulation that increases donor safety with good recipient outcomes

Kaido T., Ogawa K., Fujimoto Y., Ito T., Tomiyama K., Mori A., Ogura Y., Uemoto S.

Transplantation Vol. 97 ( 8 ) page： S30 - S32 2014.4

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The goal of this study was to examine whether the lower limit of the graft-to-recipient weight ratio (GRWR) can be safely reduced to make better use of the left lobe graft in adult-to-adult living donor liver transplantation in combination with portal pressure control. Beginning December 2007, the acceptable limit for GRWR was lowered to ≥0.7% and by April 2009, it was further lowered to ≥0.6%. A portal pressure control program targeting a final portal pressure <15 mm Hg was also introduced. The donor complication rate decreased from 13.8% to 9.3%. The overall survival of recipients with GRWR <0.8% did not differ from recipients with a GRWR ≥0.8%. In conclusion, the lower limit of the GRWR can be safely reduced to 0.6% using a left lobe graft in adult-toadult living donor liver transplantation in combination with portal pressure control.

DOI： 10.1097/01.tp.0000446268.26771.59

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Graft Reconditioning With Nitric Oxide Gas in Rat Liver Transplantation From Cardiac Death Donors

Kageyama Shoichi, Yagi Shintaro, Tanaka Hirokazu, Saito Shunichi, Nagai Kazuyuki, Hata Koichiro, Fujimoto Yasuhiro, Ogura Yasuhiro, Tolba Rene, Shinji Uemoto

TRANSPLANTATION Vol. 97 ( 6 ) page： 618 - 625 2014.3

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DOI： 10.1097/TP.0000000000000025

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How Do Transplant Surgeons Accomplish Optimal Portal Venous Flow During Living-Donor Liver Transplantation? Noninvasive Measurement of Indocyanine Green Elimination Rate

Hori Tomohide, Ogura Yasuhiro, Yagi Shintaro, Iida Taku, Taniguchi Kentaro, El Moghazy Walid M., Hedaya Mohammed Saied, Segawa Hajime, Ogawa Kohei, Kogure Takayuki, Uemoto Shinji

SURGICAL INNOVATION Vol. 21 ( 1 ) page： 43 - 51 2014.2

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DOI： 10.1177/1553350613487803

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Graft harvest of right posterior segment for living-donor liver transplantation.

Hori T, Oike F, Ogura Y, Ogawa K, Uemoto S

International journal of surgery case reports Vol. 5 ( 8 ) page： 516 - 22 2014

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DOI： 10.1016/j.ijscr.2014.04.015

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[Deceased donor liver transplantation receiving a liver from a child under six years old: an experience of organ retrieval from a pediatric donor in Japan].

Hamano I, Sakamoto S, Fukuda A, Uchida H, Sasaki K, Shigeta T, Kanazawa H, Nakazawa A, Kasahara M, Ogura Y, Uemoto S

Nihon Geka Gakkai zasshi Vol. 114 ( 6 ) page： 340 - 4 2013.11

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Living donor liver transplantation for Budd-Chiari syndrome with hepatic inferior vena cava obstruction after open pericardial procedures

Fukuda Akinari, Ogura Yasuhiro, Kanazawa Hiroyuki, Mori Akira, Kawaguchi Michiya, Takada Yasutsugu, Uemoto Shinji

SURGERY TODAY Vol. 43 ( 10 ) page： 1180 - 1184 2013.10

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DOI： 10.1007/s00595-012-0440-1

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Cytokine gene polymorphisms in acute cellular rejection following living donor liver transplantation: analysis of 155 donor-recipient pairs

Kamei Hideya, Masuda Satohiro, Nakamura Taro, Ishigami Masatoshi, Fujimoto Yasuhiro, Ogura Yasuhiro, Oike Fumitaka, Takada Yasutsugu, Hamajima Nobuyuki

HEPATOLOGY INTERNATIONAL Vol. 7 ( 3 ) page： 916 - 922 2013.7

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Publishing type：Research paper (scientific journal) Publisher：Hepatology International

DOI： 10.1007/s12072-013-9443-2

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Impact of Sarcopenia on Survival in Patients Undergoing Living Donor Liver Transplantation

Kaido T., Ogawa K., Fujimoto Y., Ogura Y., Hata K., Ito T., Tomiyama K., Yagi S., Mori A., Uemoto S.

AMERICAN JOURNAL OF TRANSPLANTATION Vol. 13 ( 6 ) page： 1549 - 1556 2013.6

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DOI： 10.1111/ajt.12221

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Pretransplant Serum Hepatitis C Virus RNA Levels Predict Response to Antiviral Treatment after Living Donor Liver Transplantation

Ueda Yoshihide, Kaido Toshimi, Ogura Yasuhiro, Ogawa Kohei, Yoshizawa Atsushi, Hata Koichiro, Fujimoto Yasuhiro, Miyagawa-Hayashino Aya, Haga Hironori, Marusawa Hiroyuki, Teramukai Satoshi, Uemoto Shinji, Chiba Tsutomu

PLOS ONE Vol. 8 ( 3 ) page： e58380 2013.3

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DOI： 10.1371/journal.pone.0058380

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Efficacy and safety of prophylaxis with entecavir and hepatitis B immunoglobulin in preventing hepatitis B recurrence after living-donor liver transplantation

Ueda Yoshihide, Marusawa Hiroyuki, Kaido Toshimi, Ogura Yasuhiro, Ogawa Kohei, Yoshizawa Atsushi, Hata Koichiro, Fujimoto Yasuhiro, Nishijima Norihiro, Chiba Tsutomu, Uemoto Shinji

HEPATOLOGY RESEARCH Vol. 43 ( 1 ) page： 67 - 71 2013.1

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DOI： 10.1111/j.1872-034X.2012.01020.x

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Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation

Kamei Hideya, Masuda Satohiro, Nakamura Taro, Fujimoto Yasuhiro, Oike Fumitaka, Ogura Yasuhiro, Takada Yasutsugu, Hamajima Nobuyuki

TRANSPLANT IMMUNOLOGY Vol. 28 ( 1 ) page： 14 - 17 2013.1

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Publishing type：Research paper (scientific journal) Publisher：Transplant Immunology

DOI： 10.1016/j.trim.2012.11.002

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Pediatric Liver Transplantation Using Reduced and Hyper-Reduced Left Lateral Segment Grafts: A 10-Year Single-Center Experience

Shehata M. R., Yagi S., Okamura Y., Iida T., Hori T., Yoshizawa A., Hata K., Fujimoto Y., Ogawa K., Okamoto S., Ogura Y., Mori A., Teramukai S., Kaido T., Uemoto S.

AMERICAN JOURNAL OF TRANSPLANTATION Vol. 12 ( 12 ) page： 3406 - 3413 2012.12

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DOI： 10.1111/j.1600-6143.2012.04268.x

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Liver transplantation for severe hepatitis in patients with common variable immunodeficiency

Murakawa Yasuhiro, Miyagawa-Hayashino Aya, Ogura Yasuhiro, Egawa Hiroto, Okamoto Shinya, Soejima Yuji, Kurosawa Manabu, Sumiyoshi Shinji, Uemoto Shinji, Haga Hironori

PEDIATRIC TRANSPLANTATION Vol. 16 ( 6 ) page： E210 - E216 2012.9

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DOI： 10.1111/j.1399-3046.2011.01545.x

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Non-inflammatory centrilobular sinusoidal fibrosis in pediatric liver transplant recipients under tacrolimus withdrawal

Egawa Hiroto, Miyagawa-Hayashino Aya, Haga Hironori, Teramukai Satoshi, Yoshizawa Atsushi, Ogawa Kohei, Ogura Yasuhiro, Okamoto Shinya, Kaido Toshimi, Uemoto Shinji

HEPATOLOGY RESEARCH Vol. 42 ( 9 ) page： 895 - 903 2012.9

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DOI： 10.1111/j.1872-034X.2012.01003.x

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Effects of Post-transplant Enteral Nutrition with an Immunomodulating Diet Containing Hydrolyzed Whey Peptide after Liver Transplantation

Kaido Toshimi, Ogura Yasuhiro, Ogawa Kohei, Hata Koichiro, Yoshizawa Atsushi, Yagi Shintaro, Uemoto Shinji

WORLD JOURNAL OF SURGERY Vol. 36 ( 7 ) page： 1666 - 1671 2012.7

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Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00268-012-1529-9

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Standard hepatic vein reconstruction with patch plasty using the native portal vein in adult living donor liver transplantation

Mori, A; Kaido, T; Ogura, Y; Ogawa, K; Hata, K; Yagi, S; Yoshizawa, A; Isoda, H; Shibata, T; Uemoto, S

LIVER TRANSPLANTATION Vol. 18 ( 5 ) page： 602 - 607 2012.5

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DOI： 10.1002/lt.23387

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Use of Recipient's Left Colic Artery for Arterial Reconstruction During Liver Transplantation in Alagille Syndrome With Vasculopathy: A Case Report

Shehata, MR; Yagi, S; Ogura, Y; Ogawa, K; Iida, T; Mori, A; Sumiyoshi, S; Haga, H; Uemoto, S

TRANSPLANTATION Vol. 93 ( 6 ) page： E20 - E21 2012.3

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DOI： 10.1097/TP.0b013e318247a68b

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Significance of trough monitoring for tacrolimus blood concentration and calcineurin activity in adult patients undergoing primary living-donor liver transplantation

Yano, I; Masuda, S; Egawa, H; Sugimoto, M; Fukudo, M; Yoshida, Y; Hashi, S; Yoshizawa, A; Ogura, Y; Ogawa, K; Mori, A; Kaido, T; Uemoto, S; Inui, K

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 ( 3 ) page： 259 - 266 2012.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00228-011-1129-x

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Left-sided grafts for living-donor liver transplantation and split grafts for deceased-donor liver transplantation: Their impact on long-term survival

Hori Tomohide, Uemoto Shinji, Gardner Lindsay B., Sibulesky Lena, Ogura Yasuhiro, Nguyen Justin H.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY Vol. 36 ( 1 ) page： 47 - 52 2012.2

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.clinre.2011.08.008

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Splenectomy Does Not Offer Immunological Benefits in ABO-Incompatible Liver Transplantation With a Preoperative Rituximab

Raut, V; Mori, A; Kaido, T; Ogura, Y; Taku, I; Nagai, K; Sasaki, N; Endo, K; Hata, T; Yagi, S; Egawa, H; Uemoto, S

TRANSPLANTATION Vol. 93 ( 1 ) page： 99 - 105 2012.1

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DOI： 10.1097/TP.0b013e318239e8e4

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Effect of maintenance therapy with low-dose peginterferon for recurrent hepatitis C after living donor liver transplantation

Ueda Y., Marusawa H., Kaido T., Ogura Y., Oike F., Mori A., Ogawa K., Yoshizawa A., Hatano E., Miyagawa-Hayashino A., Haga H., Egawa H., Takada Y., Uemoto S., Chiba T.

JOURNAL OF VIRAL HEPATITIS Vol. 19 ( 1 ) page： 32 - 38 2012.1

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DOI： 10.1111/j.1365-2893.2010.01398.x

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Living donor liver transplantation for recurrent hepatocellular carcinoma after liver resection

Kaido Toshimi, Mori Akira, Ogura Yasuhiro, Hata Koichiro, Yoshizawa Atsushi, Iida Taku, Yagi Shintaro, Uemoto Shinji

SURGERY Vol. 151 ( 1 ) page： 55 - 60 2012.1

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DOI： 10.1016/j.surg.2011.06.032

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How transplant surgeons can overcome the inevitable insufficiency of allograft size during adult living-donor liver transplantation: strategy for donor safety with a smaller-size graft and excellent recipient results

Hori Tomohide, Ogura Yasuhiro, Ogawa Kohei, Kaido Toshimi, Segawa Hajime, Okajima Hideaki, Kogure Takayuki, Uemoto Shinji

CLINICAL TRANSPLANTATION Vol. 26 ( 3 ) page： E324 - E334 2012

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DOI： 10.1111/j.1399-0012.2012.01664.x

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PubMed
Pre- and perioperative factors affecting infection after living donor liver transplantation

Kaido Toshimi, Mori Akira, Ogura Yasuhiro, Ogawa Kouhei, Hata Koichiro, Yoshizawa Atsushi, Yagi Shintaro, Uemoto Shinji

NUTRITION Vol. 28 ( 11-12 ) page： 1104 - 1108 2012

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DOI： 10.1016/j.nut.2012.02.007

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To the head of Papers.▲

KAKENHI (Grants-in-Aid for Scientific Research) 7

切除不能な肝門部領域胆管癌に対する生体肝移植で治癒に至る分子生物学的特性の解明

Grant number：23K08030 2023.4 - 2028.3

科学研究費助成事業基盤研究(C)

日比泰造, 大段秀樹, 大平真裕, 武冨紹信, 海野倫明, 北川雄光, 長谷川潔, 小倉靖弘, 波多野悦朗, 楳田祐三, 高田泰次, 吉住朋晴

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Authorship：Coinvestigator(s)

切除不能な肝門部領域胆管癌に対する生体肝移植（先進医療として2022年9月1日に告示）の付随研究として肝移植レシピエント中の摘出肝の臨床病理学的検討、循環腫瘍細胞の解析、摘出肝の腫瘍部および非腫瘍部のmRNA発現の網羅的解析、免疫抑制剤存在下における腫瘍増殖解析およびレシピエント・ドナーの腫瘍免疫に関わる一塩基多型解析を行い、治癒に至る分子生物学的な特性を解明する。本研究は肝門部領域胆管癌のみならず難治がんの多い肝・胆道がんの治療体系を大きく変革し、予後の飛躍的な向上に寄与することが高く期待される。
小児肝移植後持続性高EBウイルス血症の病態及びグラフト肝における線維化機序の解明

Grant number：17K10509 2017.4 - 2021.3

科学研究費助成事業基盤研究(C)

亀井秀弥, 小倉靖弘, 伊藤嘉規, 大西康晴

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Authorship：Coinvestigator(s)

小児肝移植症例では移植後免疫抑制療法下にEstein-Barr (EB) ウイルスの初感染となることが稀でなく、そのためその後高EBウイルス血症が長期にわたり持続する症例も多い。しかしその病態や臨床的意義、長期予後への影響は不明である。一方、小児肝移植領域では長期生存が重要とされるが、近年血液検査上肝機能に異常がなくてもグラフト肝の線維下が進行していることが問題視されているがその原因は未だ解明されていない。持続性高EBウイルス血症を認める小児生体肝移植症例についてウイルス学的・免疫学的な解析を行いその病態を解明するとともに、肝炎を引き起こすことでも知られるEBウイルスがグラフト肝に与える影響を病理組織学的にも検討し解明することを目的としている。肝移植後高EBウイルス血症を引き起こす病態が解明され、その特徴や特異性が解明されればその治療法や予防法も確立することが可能であると予想され、小児肝移植長期予後の向上に大きく貢献するものと考えられる。グラフト肝の評価としては肝線維化マーカーの測定に加えプロコトール肝生検により病理組織学的にも評価し２群間で比較検討する。特にEBウイルス高値群ではEBERsによる染色も行い評価する。当院にて生体肝移植を施行した小児症例に対して、入院中は週一度、外来通院加療中は４－６週間ごとにリアルタイムPCR法を用いた定量法でEBウイルス量を測定している。全血EBV-DNA量が10000IU/ml以上の状態が６ヶ月以上持続した症例をEBV持続高値群とした場合、約４割が持続高値群となっている。
The analysis of deceased donor split liver transplantation in Japan

Grant number：25461968 2013.4 - 2016.3

Sakamoto Seisuke

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Authorship：Coinvestigator(s)

According to the analysis of deceased donor split liver transplantation (SLT),including 36 cases undergoing the operation by the end of 2014, the outcome was satisfactory and compatible with the previously published data. However, the incidence of surgical complications was relatively high, and those complications tended to occur in the patients receiving right-sided split grafts. In terms of the donor criteria for SLT, it would be suitable to use the Western countries' criteria, including donor age (younger than 50 years), liver function tests (within 3 times of the upper normal limits), and less than mild steatosis. Critically-ill patients and retransplant patients have to be avoided as SLT recipient candidates, although it would not be possible to be applied at present owing to the shortage of deceased donor organs. The splitting procedure may be reconsidered to prevent surgical complications and in-situ splitting procedure may be favorable instead of ex-vivo splitting procedure.
Developmemt of novel psychosocial evaluation method in liver transplantation for alcohol liver failure

Grant number：24591875 2012.4 - 2018.3

Onishi Yasuharu

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Authorship：Coinvestigator(s)

Recipients' re-drinking in 20-50% after liver transplantation for alcoholic liver failure is a social problem that could negate transplanted organs provided free of donor. Psychosocial evaluation and long-term follow-up from the preoperative point of view are also important worldwide.
We created psychosocial criteria and compared retrospectively with "candidate for transplant recipients for alcoholic liver failure" and "candidate for other liver transplant recipients" to investigate the comprehensive factors. We have been conducting retrospective examination using psychosocial evaluation criteria established at our hospital, and we have clarified the effectiveness of this evaluation method so far at the conference.
Impact of nitric oxide with oxygen gas persufflation on marginal graft in liver transplantation

Grant number：24591877 2012.4 - 2015.3

YAGI Shintaro

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Authorship：Coinvestigator(s)

We established small-for-size graft liver transplantation model in pig, which is 30% partial liver graft volume using right-lateral lobe. We investigated the effect of nitric oxide (NO) gas during liver preservation on small-for-size livers after transplantation. Gaseous oxygen with NO (40 ppm) was insufflated into the livers through the suprahepatic vena cava during cold storage (VSNOP group). Livers in Control group was preserved by simple cold storage.
One recipients in VSNOP group survived for 7 days, and the survival rates in VSNOP group tended to be better compared with control group. Pressure gradient between portal vein and inferior vena cava of livers preserved by VSNOP tended to be lower compared with the control livers just behind portal reperfusion.
Towards Elucidation of a novel mechanism for Pathogenesis of coagulation and fibrinolysis abnormalities in liver transplantation

Grant number：23390313 2011.4 - 2014.3

UEMOTO Shinji

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Authorship：Coinvestigator(s)

Thrombotic microangiopathy (TMA) is one of the life threatening diseases, which characterized by aggregation of platelets in systemic circulation, and therefore multiple organ dysfunction. The purpose of this study is to clarify the clinical characteristics and prognostic factors of TMA after liver transplantation (LTx). A total of 290 LTx patients from April 2006 to March 2013 were evaluated. We elucidated that the ADAMTS13 activity decreased by more than half in all patients and that TMA is an inevitable process after LTx because of cold-ischemia/warm-reperfusion (CI/WR) during graft preservation. Pathological Confirmation revealed that sinusoidal injury after CI/WR activated complement system, thus regulation of complement activation could be the target to improve the early outcome after LTx.
Challenge of extending warm ischemic time in rat liver transplantation from cardiac death donors

Grant number：22591405 2010.4 - 2013.3

OGURA Yasuhiro

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Authorship：Principal investigator

Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

Liver transplant outcomes using grafts donated after cardiac death (DCD) remain poor. Our goal of this study was to extend the warm ischemic time in rat liver transplantation from DCD donors. For this purpose, it is important to control the ischemic/reperfusion (I/R) injury after transplantation. There are a couple of reports to prevent I/R injury, and we applied venous systemic oxygen persufflation (VSOP) and nitric oxide (NO) gas administration.
Using rat liver transplantation models from 60 minutes DCD donors, VSOP-NO treatment could effectively decreasing the damage of I/R injury, leading to the better survival. However, we failed to extend the warm ischemic time by this methods. There may be a limitation in these graft reconditioning procedures, further investigation to understand this phenomena is required.

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To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲