Updated on 2024/10/17

写真a

 
KATO Sawako
 
Organization
Graduate School of Medicine Designated associate professor
Title
Designated associate professor
Contact information
メールアドレス

Degree 1

  1. 博士(医学) ( 2004.5   名古屋大学 ) 

Current Research Project and SDGs 1

  1. 生活習慣病

Research History 2

  1. Nagoya University   Graduate School of Medicine   Designated associate professor

    2024.4

  2. Nagoya University   Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division   Designated lecturer

    2015.4

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Medicine

    - 2003.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 1995.3

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    Country: Japan

Professional Memberships 5

  1. 日本腎臓学会   評議員

    2014.4

  2. 日本内科学会   内科学会専門医

  3. American Society of Nephrology   Member

    2008.6

  4. The European Renal Association European Dialysis and Transplant Association   Associate Member

  5. 日本透析医学会   会員

 

Papers 65

  1. Lifestyle intervention using Internet of Things (IoT) for the elderly: A study protocol for a randomized control trial (the BEST-LIFE study). Reviewed

    Kato S, Ando M, Kondo T, Yoshida Y, Honda H, Maruyama S

    Nagoya journal of medical science   Vol. 80 ( 2 ) page: 175-182   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.80.2.175

    PubMed

  2. Renoprotective effects of topiroxostat for hyperuremic patients with overt diabetic nephropathy study (ETUDE Study): A prospective, randomized, multicenter clinical trial. Reviewed

    Mizukoshi T, Kato S, Ando M, Sobajima H, Ohashi N, Naruse T, Saka Y, Shimizu H, Nagata T, Maruyama S

    Nephrology (Carlton, Vic.)     2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/nep.13177

    PubMed

  3. Randomized control trial for the assessment of the anti-albuminuric effects of topiroxostat in hyperuricemic patients with diabetic nephropathy (the ETUDE study). Reviewed

    Kato S, Ando M, Mizukoshi T, Nagata T, Katsuno T, Kosugi T, Tsuboi N, Maruyama S

    Nagoya journal of medical science   Vol. 78 ( 2 ) page: 135-42   2016.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  4. High Ferritin Level and Malnutrition Predict High Risk of Infection-Related Hospitalization in Incident Dialysis Patients: A Japanese Prospective Cohort Study. Reviewed

    Kato S, Lindholm B, Yuzawa Y, Tsuruta Y, Nakauchi K, Yasuda K, Sugiura S, Morozumi K, Tsuboi N, Maruyama S

    Blood purification   Vol. 42 ( 1 ) page: 56-63   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000445424

    PubMed

  5. Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease. Reviewed

    Kato S, Shiels PG, McGuinness D, Lindholm B, Stenvinkel P, Nordfors L, Qureshi AR, Yuzawa Y, Matsuo S, Maruyama S

    Blood purification   Vol. 41 ( 1-3 ) page: 25-33   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000440971

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  6. Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial. Reviewed

    Kato S, Maruyama S, Makino H, Wada J, Ogawa D, Uzu T, Araki H, Koya D, Kanasaki K, Oiso Y, Goto M, Nishiyama A, Kobori H, Imai E, Ando M, Matsuo S

    Clinical and experimental nephrology   Vol. 19 ( 6 ) page: 1098-106   2015.12

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    DOI: 10.1007/s10157-015-1106-2

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  7. Neutrophil/lymphocyte ratio as a predictor of cardiovascular events in incident dialysis patients: a Japanese prospective cohort study. Reviewed

    Abe T, Kato S, Tsuruta Y, Sugiura S, Katsuno T, Kosugi T, Tsuboi N, Matsuo S, Maruyama S

    Clinical and experimental nephrology   Vol. 19 ( 4 ) page: 718-24   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-014-1046-2

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  8. DNA hypermethylation and inflammatory markers in incident Japanese dialysis patients. Reviewed

    Nephron extra   Vol. 2 ( 1 ) page: 159-68   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000339437

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  9. Aspects of immune dysfunction in end-stage renal disease. Reviewed

    Kato S, Chmielewski M, Honda H, Pecoits-Filho R, Matsuo S, Yuzawa Y, Tranaeus A, Stenvinkel P, Lindholm B

    Clinical journal of the American Society of Nephrology : CJASN   Vol. 3 ( 5 ) page: 1526-33   2008.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2215/CJN.00950208

    PubMed

  10. Association between oestrogen receptor alpha gene polymorphism and mortality in female end-stage renal disease patients. Reviewed

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   Vol. 22 ( 9 ) page: 2571-7   2007.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gfm225

    PubMed

  11. Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4. Reviewed

    Kato S, Yuzawa Y, Tsuboi N, Maruyama S, Morita Y, Matsuguchi T, Matsuo S

    Journal of the American Society of Nephrology : JASN   Vol. 15 ( 5 ) page: 1289-99   2004.5

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    PubMed

  12. Association between magnesium, erythropoietin resistance and mortality: the Japanese Dialysis Outcomes and Practice Patterns Study (J-DOPPS) Reviewed International journal

    Kato, S; Wang, J; Onishi, Y; Nangaku, M

    CLINICAL KIDNEY JOURNAL   Vol. 17 ( 7 ) page: sfae153   2024.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ckj/sfae153

    Web of Science

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  13. A Prospective, Randomized Clinical Trial of Etelcalcetide in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism (the DUET Trial) Reviewed International journal

    Itano, Y; Kato, S; Tsuboi, M; Kasuga, H; Tsuruta, Y; Sato, F; Hishida, M; Ishimoto, T; Kosugi, T; Ando, M; Kuwatsuka, Y; Maruyama, S

    KIDNEY INTERNATIONAL REPORTS   Vol. 5 ( 12 ) page: 2168 - 2177   2020.12

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ekir.2020.09.010

    Web of Science

    PubMed

  14. Inter-leg systolic blood pressure difference predicts cardiovascular events and mortality in incident hemodialysis patients Reviewed International coauthorship International journal

    Kato, S; Lindholm, B; Qureshi, AR; Mukai, H; Yuzawa, Y; Maruyama, S

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 43 ( 4 ) page: 217 - 224   2020.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0391398819882703

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  15. Rationale and design of the Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study Reviewed International journal

    Kurasawa, S; Kato, S; Ozeki, T; Akiyama, S; Ishimoto, T; Mizuno, M; Tsuboi, N; Kato, N; Kosugi, T; Maruyama, S

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 28 ( 5 ) page: 431 - 439   2024.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-023-02449-4

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  16. Basigin is released in extracellular vesicles derived from the renal tubular epithelium in response to albuminuria Reviewed International journal

    Watanabe, T; Maeda, K; Kato, N; Seko, H; Sugimura, M; Sato, Y; Ryuge, A; Kato, S; Kadomatsu, K; Maruyama, S; Kosugi, T

    NEPHROLOGY   Vol. 28 ( 11 ) page: 629 - 638   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/nep.14227

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  17. Relationship between the lower limit of systolic blood pressure target and kidney function decline in advanced chronic kidney disease: an instrumental variable analysis from the REACH-J CKD cohort study Reviewed International journal

    Kurasawa, S; Yasuda, Y; Kato, S; Maruyama, S; Okada, H; Kashihara, N; Narita, I; Wada, T; Yamagata, K

    HYPERTENSION RESEARCH   Vol. 46 ( 11 ) page: 2478 - 2487   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-023-01358-z

    Web of Science

    PubMed

  18. Rationale and study design of a randomized controlled trial to investigate the renoprotective effect of canagliflozin assessed by test of renal hemodynamics in diabetic kidney disease (the FAGOTTO study) Reviewed International journal

    Kato, S; Kuwatsuka, Y; Ando, M; Tatematsu, Y; Nishibori, N; Maruyama, S

    BMC NEPHROLOGY   Vol. 24 ( 1 ) page: 228   2023.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12882-023-03277-0

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  19. Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study Reviewed International journal

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakamura, N; Iitani, Y; Moriyama, Y; Emoto, R; Kato, S; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Matsui, S; Kajiyama, H

    DIABETOLOGY & METABOLIC SYNDROME   Vol. 15 ( 1 ) page: 123   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13098-023-01103-z

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  20. Effect of Low-Density Lipoprotein Apheresis on Quality of Life in Patients with Diabetes, Proteinuria, and Hypercholesterolemia Reviewed International journal

    Hara, A; Wada, T; Muso, E; Maruyama, S; Kato, S; Furuichi, K; Yoshimura, K; Toyama, T; Sakai, N; Suzuki, H; Tsukamoto, T; Miyazaki, M; Sato, E; Abe, M; Shibagaki, Y; Narita, I; Goto, S; Sakamaki, Y; Yokoyama, H; Mori, N; Tanaka, S; Yuzawa, Y; Hasegawa, M; Matsubara, T; Wada, J; Tanabe, K; Masutani, K; Abe, Y; Tsuruya, K; Fujimoto, S; Iwatsubo, S; Tsuda, A; Suzuki, H; Kasuno, K; Terada, Y; Nakata, T; Iino, N; Sofue, T; Miyata, H; Nakano, T; Ohtake, T; Kobayashi, S

    BLOOD PURIFICATION   Vol. 52 ( 4 ) page: 373 - 381   2023.4

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    DOI: 10.1159/000527900

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  21. Impact of etelcalcetide on fibroblast growth factor-23 and calciprotein particles in patients with secondary hyperparathyroidism undergoing haemodialysis Reviewed International journal

    Hashimoto, Y; Kato, S; Kuro-o, M; Miura, Y; Itano, Y; Ando, M; Kuwatsuka, Y; Maruyama, S

    NEPHROLOGY   Vol. 27 ( 9 ) page: 763 - 770   2022.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/nep.14081

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  22. Increased Monocyte/Lymphocyte Ratio as Risk Marker for Cardiovascular Events and Infectious Disease Hospitalization in Dialysis Patients Reviewed International coauthorship International journal

    Muto, R; Kato, S; Lindholm, B; Qureshi, AR; Ishimoto, T; Kosugi, T; Maruyama, S

    BLOOD PURIFICATION   Vol. 51 ( 9 ) page: 747 - 755   2022.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000519289

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  23. Effect of body mass index on the association between alcohol consumption and the development of chronic kidney disease Reviewed International journal

    Hashimoto, Y; Imaizumi, T; Kato, S; Yasuda, Y; Ishimoto, T; Kawashiri, H; Hori, A; Maruyama, S

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 20440   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-99222-y

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  24. Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A retrospective analysis of data from the Japan Renal Biopsy Registry Reviewed International journal

    Nakagawa, N; Mizuno, M; Kato, S; Maruyama, S; Sato, H; Nakaya, I; Sugiyama, H; Fujimoto, S; Miura, K; Matsumura, C; Gotoh, Y; Suzuki, H; Kuroki, A; Yoshino, A; Nakatani, S; Hiromura, K; Yamamoto, R; Yokoyama, H; Narita, I; Isaka, Y

    PLOS ONE   Vol. 16 ( 9 ) page: e0257397   2021.9

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    DOI: 10.1371/journal.pone.0257397

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  25. Clinical impact of urinary CD11b and CD163 on the renal outcomes of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis Reviewed International journal

    Yokoe, Y; Tsuboi, N; Imaizumi, T; Kitagawa, A; Karasawa, M; Ozeki, T; Endo, N; Sawa, Y; Kato, S; Katsuno, T; Maruyama, S; Yamagata, K; Usui, J; Nagata, M; Sada, KE; Sugiyama, H; Amano, K; Arimura, Y; Atsumi, T; Yuzawa, Y; Dobashi, H; Takasaki, Y; Harigai, M; Hasegawa, H; Makino, H; Matsuo, S

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 36 ( 8 ) page: 1452 - 1463   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gfaa097

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  26. High urinary glucose is associated with improved renal prognosis in patients with diabetes mellitus Reviewed International journal

    Itano, Y; Sobajima, H; Ohashi, N; Shibata, T; Fujiya, A; Nagata, T; Ando, M; Imaizumi, T; Kubo, Y; Ozeki, T; Katsuno, T; Kato, S; Yasuda, Y; Maruyama, S

    JOURNAL OF DIABETES INVESTIGATION   Vol. 12 ( 6 ) page: 998 - 1006   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13428

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  27. Nephrotic syndrome with focal segmental glomerular lesions unclassified by Columbia classification; Pathology and clinical implication Reviewed International journal

    Ozeki, T; Nagata, M; Katsuno, T; Inagaki, K; Goto, K; Kato, S; Yasuda, Y; Tsuboi, N; Maruyama, S

    PLOS ONE   Vol. 16 ( 1 ) page: e0244677   2021.1

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    DOI: 10.1371/journal.pone.0244677

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  28. Effects of LDL apheresis on proteinuria in patients with diabetes mellitus, severe proteinuria, and dyslipidemia Reviewed International journal

    Wada, T; Hara, A; Muso, E; Maruyama, S; Kato, S; Furuichi, K; Yoshimura, K; Toyama, T; Sakai, N; Suzuki, H; Tsukamoto, T; Miyazaki, M; Sato, E; Abe, M; Shibagaki, Y; Narita, I; Goto, S; Sakamaki, Y; Yokoyama, H; Mori, N; Yuzawa, Y; Hasegawa, M; Matsubara, T; Wada, J; Tanabe, K; Masutani, K; Abe, Y; Tsuruya, K; Fujimoto, S; Iwatsubo, S; Tsuda, A; Suzuki, H; Kasuno, K; Terada, Y; Nakata, T; Iino, N; Sofue, T; Miyata, H; Nakano, T; Ohtake, T; Kobayashi, S

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 1 ) page: 1 - 8   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-020-01959-9

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  29. Validity of "One-size-fits-all" Approaches for the National Health Screening and Education Program: A Large-scale Cohort Study of Corporate Insurance Beneficiaries Reviewed International journal

    Kikuchi, K; Imaizumi, T; Ando, M; Kato, S; Kondo, T; Honda, H; Yoshida, Y; Maruyama, S

    INTERNAL MEDICINE   Vol. 60 ( 11 ) page: 1681 - 1689   2021

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.5515-20

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  30. Survival Benefit of Maintained or Increased Body Mass Index in Patients Undergoing Extended-Hours Hemodialysis Without Dietary Restrictions Reviewed International journal

    Hishida, M; Imaizumi, T; Nishiyama, T; Okazaki, M; Kaihan, AB; Kato, S; Kubo, Y; Ando, M; Kaneda, H; Maruyama, S

    JOURNAL OF RENAL NUTRITION   Vol. 30 ( 2 ) page: 154 - 162   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.jrn.2019.06.002

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  31. Effectiveness of Lifestyle Intervention Using the Internet of Things System for Individuals with Early Type 2 Diabetes Mellitus Reviewed International journal

    Kato, S; Ando, M; Honda, H; Yoshida, Y; Imaizumi, T; Yamamoto, N; Maruyama, S

    INTERNAL MEDICINE   Vol. 59 ( 1 ) page: 45 - 53   2020

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.3150-19

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  32. Rationale and study design of a randomized controlled trial for development of a treatment strategy for chronic kidney disease-mineral and bone disorder by multilateral mechanism of etelcalcetide hydrochloride (the DUET study) Reviewed International journal

    Kato, S; Tsuboi, M; Ando, M; Itano, Y; Maruyama, S

    RENAL REPLACEMENT THERAPY   Vol. 5 ( 1 )   2019.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s41100-019-0236-5

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  33. Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease Reviewed International journal

    Ozeki, T; Katsuno, T; Hayashi, H; Kato, S; Yasuda, Y; Ando, M; Tsuboi, N; Hagiwara, D; Arima, H; Maruyama, S

    AMERICAN JOURNAL OF NEPHROLOGY   Vol. 49 ( 1 ) page: 54 - 63   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000495352

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  34. Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study. Reviewed

    Katsuno T, Masuda T, Saito S, Kato N, Ishimoto T, Kato S, Kosugi T, Tsuboi N, Kitamura H, Tsuzuki T, Ito Y, Maruyama S

    Clinical and experimental nephrology     2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-018-1630-y

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  35. Clinical impact of endocapillary proliferation according to the Oxford classification among adults with Henoch-Schönlein purpura nephritis: a multicenter retrospective cohort study. Reviewed

      Vol. 19 ( 1 ) page: 208   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12882-018-1009-z

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  36. Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis. Reviewed

    Katsuno T, Ozaki T, Ozeki T, Hachiya A, Kim H, Kato N, Ishimoto T, Kato S, Kosugi T, Tsuboi N, Mizuno M, Ito Y, Maruyama S

    Clinical and experimental nephrology     2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-018-1590-2

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  37. Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS. Reviewed International journal

    Shimizu M, Furuichi K, Toyama T, Funamoto T, Kitajima S, Hara A, Ogawa D, Koya D, Ikeda K, Koshino Y, Kurokawa Y, Abe H, Mori K, Nakayama M, Konishi Y, Samejima KI, Matsui M, Yamauchi H, Gohda T, Fukami K, Nagata D, Yamazaki H, Yuzawa Y, Suzuki Y, Fujimoto S, Maruyama S, Kato S, Naito T, Yoshimura K, Yokoyama H, Wada T, Research Group of Diabetic Nephropathy the Ministry of Health Labour and Welfare of Japan and Japan Agency for Medical Research and Development.

    Clinical and experimental nephrology   Vol. 22 ( 2 ) page: 377 - 387   2018.4

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    DOI: 10.1007/s10157-017-1467-9

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  38. Effect of dietary energy and polymorphisms in BRAP and GHRL on obesity and metabolic traits. Reviewed

    Imaizumi T, Ando M, Nakatochi M, Yasuda Y, Honda H, Kuwatsuka Y, Kato S, Kondo T, Iwata M, Nakashima T, Yasui H, Takamatsu H, Okajima H, Yoshida Y, Maruyama S

    Obesity research & clinical practice   Vol. 12 ( 1S1 ) page: 39-48   2018.1

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    DOI: 10.1016/j.orcp.2016.05.004

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  39. Treatment patterns and steroid dose for adult minimal change disease relapses: A retrospective cohort study. Reviewed

    Ozeki T, Ando M, Yamaguchi M, Katsuno T, Kato S, Yasuda Y, Tsuboi N, Maruyama S

    PloS one   Vol. 13 ( 6 ) page: e0199228   2018

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    DOI: 10.1371/journal.pone.0199228

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  40. The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients. Reviewed

    Kaihan AB, Yasuda Y, Katsuno T, Kato S, Imaizumi T, Ozeki T, Hishida M, Nagata T, Ando M, Tsuboi N, Maruyama S

    Clinical and experimental nephrology   Vol. 21 ( 6 ) page: 986-994   2017.12

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    DOI: 10.1007/s10157-017-1393-x

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  41. Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study protocol. Reviewed

    Onoue T, Goto M, Kobayashi T, Tominaga T, Ando M, Honda H, Yoshida Y, Tosaki T, Yokoi H, Kato S, Maruyama S, Arima H

    Nagoya journal of medical science   Vol. 79 ( 3 ) page: 323-329   2017.8

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    DOI: 10.18999/nagjms.79.3.323

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  42. Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers. Reviewed

    Imaizumi T, Ando M, Nakatochi M, Maruyama S, Yasuda Y, Honda H, Kuwatsuka Y, Kato S, Kondo T, Iwata M, Nakashima T, Yasui H, Takamatsu H, Okajima H, Yoshida Y, Matsuo S

    Clinical and experimental nephrology   Vol. 21 ( 3 ) page: 457-464   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-016-1315-3

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  43. 30% GFR DECLINE WITHIN 2 YEARS WAS EARLIER BUT INSENSITIVE RENAL OUTCOME AMONG CKD PATIENTS INITIATED HEMODIALYSIS: A LONGITUDINAL GFR TRAJECTORY ANALYSIS Reviewed International journal

    Kaihan, AB; Yasuda, Y; Katsuno, T; Kato, S; Imaizumi, T; Ozeki, T; Hishida, M; Inagaki, K; Hachiya, A; Tsubio, N; Maruyama, S

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 32   page: 133 - 133   2017.5

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  44. Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers. Reviewed

    Kubo Y, Imaizumi T, Ando M, Nakatochi M, Yasuda Y, Honda H, Kuwatsuka Y, Kato S, Kikuchi K, Kondo T, Iwata M, Nakashima T, Yasui H, Takamatsu H, Okajima H, Yoshida Y, Maruyama S

    PloS one   Vol. 12 ( 10 ) page: e0185476   2017

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    DOI: 10.1371/journal.pone.0185476

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  45. Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission. Reviewed

    Inagaki K, Yasuda Y, Ando M, Kaihan AB, Hachiya A, Ozeki T, Hishida M, Imaizumi T, Katsuno T, Kato S, Tsuboi N, Maruyama S

    PloS one   Vol. 12 ( 11 ) page: e0187607   2017

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    DOI: 10.1371/journal.pone.0187607

    PubMed

  46. Relationship between abdominal aortic and coronary artery calcification as detected by computed tomography in chronic kidney disease patients. Reviewed

    Takayama Y, Yasuda Y, Suzuki S, Shibata Y, Tatami Y, Shibata K, Niwa M, Sawai A, Morimoto R, Kato S, Ishii H, Maruyama S, Murohara T

    Heart and vessels   Vol. 31 ( 7 ) page: 1030-7   2016.7

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    DOI: 10.1007/s00380-015-0712-y

    PubMed

  47. Impact of non-invasive cardiovascular screening programs as a predictor of cardiovascular events among asymptomatic chronic kidney disease patients. Reviewed

    Sawai A, Yasuda Y, Suzuki S, Ishii H, Goto M, Kato S, Hayashi M, Maruyama S, Murohara T, Oiso Y, Matsuo S

    Clinical and experimental nephrology   Vol. 20 ( 3 ) page: 416-24   2016.6

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    DOI: 10.1007/s10157-015-1169-0

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  48. The effectiveness and safety of modest exercise in Japanese patients with chronic kidney disease: a single-armed interventional study. Reviewed

    Hamada M, Yasuda Y, Kato S, Arafuka H, Goto M, Hayashi M, Kajita E, Maruyama S

    Clinical and experimental nephrology   Vol. 20 ( 2 ) page: 204-11   2016.4

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    DOI: 10.1007/s10157-015-1147-6

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  49. Impact of abdominal aortic calcification on long-term cardiovascular outcomes in patients with chronic kidney disease. Reviewed

    Tatami Y, Yasuda Y, Suzuki S, Ishii H, Sawai A, Shibata Y, Ota T, Shibata K, Niwa M, Morimoto R, Hayashi M, Kato S, Maruyama S, Murohara T

    Atherosclerosis   Vol. 243 ( 2 ) page: 349-55   2015.12

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    DOI: 10.1016/j.atherosclerosis.2015.10.016

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  50. Increase of Antimyeloperoxidase Antineutrophil Cytoplasmic Antibody (ANCA) in Patients with Renal ANCA-associated Vasculitis: Association with Risk to Relapse. Reviewed

    Yamaguchi M, Ando M, Kato S, Katsuno T, Kato N, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S

    The Journal of rheumatology   Vol. 42 ( 10 ) page: 1853-60   2015.10

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    DOI: 10.3899/jrheum.141622

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  51. Development and validation of a short-version checklist for patients undergoing hemodialysis based on the International Classification of Functioning, Disability and Health. Reviewed

    Tsutsui H, Ohkubo T, Tsuruta Y, Kato S, Yasuda Y, Oshida Y

    Clinical and experimental nephrology   Vol. 19 ( 5 ) page: 953-60   2015.10

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    DOI: 10.1007/s10157-014-1075-x

    PubMed

  52. The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. Reviewed

    Tanaka A, Katsuno T, Ozaki T, Sakata F, Kato N, Suzuki Y, Kosugi T, Kato S, Tsuboi N, Sato W, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S

    Acta cardiologica   Vol. 70 ( 2 ) page: 217-23   2015.4

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    DOI: 10.2143/AC.70.2.3073514

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  53. Clinical impact of kidney function on presepsin levels. Reviewed

    Nagata T, Yasuda Y, Ando M, Abe T, Katsuno T, Kato S, Tsuboi N, Matsuo S, Maruyama S

    PloS one   Vol. 10 ( 6 ) page: e0129159   2015

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    DOI: 10.1371/journal.pone.0129159

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  54. Identification of an interaction between VWF rs7965413 and platelet count as a novel risk marker for metabolic syndrome: an extensive search of candidate polymorphisms in a case-control study. Reviewed

    Nakatochi M, Ushida Y, Yasuda Y, Yoshida Y, Kawai S, Kato R, Nakashima T, Iwata M, Kuwatsuka Y, Ando M, Hamajima N, Kondo T, Oda H, Hayashi M, Kato S, Yamaguchi M, Maruyama S, Matsuo S, Honda H

    PloS one   Vol. 10 ( 2 ) page: e0117591   2015

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    DOI: 10.1371/journal.pone.0117591

    PubMed

  55. Validity of a checklist for hemodialysis patients based on the International Classification Of Functioning, Disability and Health. Reviewed

    Tsutsui H, Ojima T, Tsuruta Y, Kato S, Yasuda Y, Oshida Y

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   Vol. 18 ( 5 ) page: 473-80   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1744-9987.12163

    PubMed

  56. A multicenter cross-sectional study of circulating soluble urokinase receptor in Japanese patients with glomerular disease. Reviewed

    Wada T, Nangaku M, Maruyama S, Imai E, Shoji K, Kato S, Endo T, Muso E, Kamata K, Yokoyama H, Fujimoto K, Obata Y, Nishino T, Kato H, Uchida S, Sasatomi Y, Saito T, Matsuo S

    Kidney international   Vol. 85 ( 3 ) page: 641-8   2014.3

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    DOI: 10.1038/ki.2013.544

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  57. Patient age and the prognosis of idiopathic membranous nephropathy. Reviewed

    Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S

    PloS one   Vol. 9 ( 10 ) page: e110376   2014

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    DOI: 10.1371/journal.pone.0110376

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  58. Smoking is a risk factor for the progression of idiopathic membranous nephropathy. Reviewed

    Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S

    PloS one   Vol. 9 ( 6 ) page: e100835   2014

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    DOI: 10.1371/journal.pone.0100835

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  59. Validation of the equations for estimating daily sodium excretion from spot urine in patients with chronic kidney disease

    Imai Enyu, Yasuda Yoshinari, Horio Masaru, Shibata Kanako, Kato Sawako, Mizutani Yu, Imai Junko, Hayashi Mutsuharu, Kamiya Hideki, Oiso Yutaka, Murohara Toyoaki, Maruyama Shoichi, Matsuo Seiichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 15 ( 6 ) page: 861-867   2011.12

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    DOI: 10.1007/s10157-011-0523-0

    Web of Science

  60. Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice

    Kurata Kei, Maruyama Shoichi, Kato Sawako, Sato Waichi, Yamamoto Jun-ichiro, Ozaki Takenori, Nitta Atsumi, Nabeshima Toshitaka, Morita Yoshiki, Mizuno Masashi, Ito Yasuhiko, Yuzawa Yukio, Matsuo Seiichi

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 297 ( 6 ) page: F1510-F1517   2009.12

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    DOI: 10.1152/ajprenal.90330.2008

    Web of Science

  61. Characteristics and causes of immune dysfunction related to uremia and dialysis. Reviewed

    Hauser AB, Stinghen AE, Kato S, Bucharles S, Aita C, Yuzawa Y, Pecoits-Filho R

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis   Vol. 28 Suppl 3   page: S183-7   2008.6

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  62. Comparison of nutritional and inflammatory markers in dialysis patients with reduced appetite. Reviewed

    The American journal of clinical nutrition   Vol. 85 ( 3 ) page: 695-701   2007.3

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    DOI: 10.1093/ajcn/85.3.695

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  63. Associations between the CYBA 242C/T and the MPO -463G/A polymorphisms, oxidative stress and cardiovascular disease in chronic kidney disease patients. Reviewed

    Blood purification   Vol. 25 ( 2 ) page: 210-8   2007

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    DOI: 10.1159/000100419

    PubMed

  64. Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70. Reviewed

    Suzuki S, Maruyama S, Sato W, Morita Y, Sato F, Miki Y, Kato S, Katsuno M, Sobue G, Yuzawa Y, Matsuo S

    Kidney international   Vol. 67 ( 6 ) page: 2210-20   2005.6

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    DOI: 10.1111/j.1523-1755.2005.00326.x

    PubMed

  65. In vivo gene transfer of endo-beta-galactosidase C removes alphaGal antigen on erythrocytes and endothelial cells of the organs. Reviewed

    Miki Y, Maruyama S, Liu D, Kobayashi T, Sato F, Shimizu H, Kato S, Sato W, Morita Y, Yuzawa Y, Muramatsu T, Matsuo S

    Xenotransplantation   Vol. 11 ( 5 ) page: 444-51   2004.9

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    DOI: 10.1111/j.1399-3089.2004.00163.x

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Presentations 9

  1. Influence of SGLT2I on tubulointerstitium in DKD patients with moderate renal dysfunction International conference

    Murakami, K; Kato, S; Sugaya, T; Kuwatsuka, Y; Ando, M; Maruyama, S

    NEPHROLOGY DIALYSIS TRANSPLANTATION  2024.5 

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    Event date: 2024.5

    Language:English   Presentation type:Oral presentation (general)  

  2. The Alteration of Neutrophil Nuclear Morphology: A Potential Predictor for Corticosteroid Response in IgA Nephropathy International conference

    Muto, R; Kato, S; Maruyama, S

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY  2021.10 

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    Event date: 2021.10

    Language:English  

  3. DOSE-RESPONSE RELATIONSHIP BETWEEN ALCOHOL CONSUMPTION AND THE RISK OF DEVELOPING CKD: RETROSPECTIVE COHORT STUDY International conference

    Hashimoto, Y; Imaizumi, T; Hori, A; Kato, S; Yasuda, Y; Maruyama, S

    NEPHROLOGY DIALYSIS TRANSPLANTATION  2021.5 

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    Event date: 2021.5

    Language:English   Presentation type:Poster presentation  

  4. IMPACT OF ACTIVE VITAMIN D AND CALCIUM PREPARATION ON VASCULAR CALCIFICATION MARKERS IN HEMODIALYSIS PATIENTS WITH HYPOCALCEMIA INDUCED BY CALCIMIMETICS International conference

    Hashimoto, Y; Kato, S; Tsuboi, M; Kuro-O, M; Kuwatsuka, Y; Ando, M; Maruyama, S

    NEPHROLOGY DIALYSIS TRANSPLANTATION  2021.5 

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    Event date: 2021.5

    Language:English   Presentation type:Poster presentation  

  5. INCREASED MONOCYTE/LYMPHOCYTE RATIO ASSOCIATES WITH INFECTIOUS HOSPITALIZATION IN INCIDENT DIALYSIS PATIENTS International conference

    Kato Sawako, Bengt Lindholm, Yukio Yuzawa, Tsuruta Yoshinari, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION 

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    Event date: 2018.5

    Language:English   Presentation type:Poster presentation  

  6. HIGHER NEUTROPHIL TO LYMPHOCYTE RATIO ASSOCIATES WITH POOR CLINICAL OUTCOME IN CKD5 PATIENTS International coauthorship International conference

    Mukai, H; Kato, S; Lindholm, B; Heimbürger, O; Barany, P; Washida, N; Stenvinkel, P; Qureshi, AR

    NEPHROLOGY DIALYSIS TRANSPLANTATION  2018.5 

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    Event date: 2018.5

    Language:English   Presentation type:Poster presentation  

  7. INCREASED MONOCYTE/LYMPHOCYTE RATIO ASSOCIATES WITH INFECTIOUS HOSPITALIZATION IN INCIDENT DIALYSIS PATIENTS International coauthorship International conference

    Kato, S; Bengt, L; Yukio, Y; Tsuruta, Y; Maruyama, S

    NEPHROLOGY DIALYSIS TRANSPLANTATION  2018.5 

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    Event date: 2018.5

    Language:English   Presentation type:Poster presentation  

  8. HIGHER NEUTROPHIL TO LYMPHOCYTE RATIO ASSOCIATES WITH POOR CLINICAL OUTCOME IN CKD5 PATIENTS International coauthorship International conference

    Mukai, H; Kato, S; Lindholm, B; Heimbürger, O; Barany, P; Washida, N; Stenvinkel, P; Qureshi, AR

    NEPHROLOGY DIALYSIS TRANSPLANTATION  2018.5 

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    Event date: 2018.5

    Language:English   Presentation type:Poster presentation  

  9. INCREASED MONOCYTE/LYMPHOCYTE RATIO ASSOCIATES WITH INFECTIOUS HOSPITALIZATION IN INCIDENT DIALYSIS PATIENTS International coauthorship International conference

    Kato, S; Bengt, L; Yukio, Y; Tsuruta, Y; Maruyama, S

    NEPHROLOGY DIALYSIS TRANSPLANTATION  2018.5 

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    Language:English   Presentation type:Poster presentation  

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 慢性腎臓病患者における生体内細菌叢をターゲットにした新規抗老化療法の開発

    Grant number:22K08328  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    加藤 佐和子, 丸山 彰一, 今泉 貴広, 小杉 智規

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    慢性腎臓病(CKD)患者の表現系は老化に見られる諸変化に酷似している。通常の維持血液透析患者(従来透析)と長時間透析患者、保存期腎不全患者は、尿毒症にさらされている強度や条件が異なる。尿毒症存在下において、どのような外的・内的環境負荷(Allostatic load)が免疫学的変調と慢性炎症をきたし、Microbiomeの変調をきたすのか、老化の指標となる遺伝子保護の不調(テロメア消耗)に関与しているか解析し、実際の心疾患、感染症、死亡率と比較することにより、腸内細菌叢の改善をターゲットとしたCKD患者の新規治療戦略の構築を目指すものである。
    最も深刻な尿毒症下にある従来透析療法施行中(NICE-GENEコホート研究)の患者、長時間透析により尿毒症を可及的に管理している患者(RRTRコホート研究)、保存期腎不全患者(N-KDRG)のサンプルの取集を予定通り遂行している。登録状況は順調である。NICE-GENEコホート研究では現在までに約300名の登録、RRTRコホート研究では約200名の登録(全体で約300名登録のうち長時間透析200名)、N-KDRGでは約100名の登録が達成されている。環境因子(allostatic load)の情報収集については、患者背景・臨床情報(腎機能、炎症、栄養状態、心不全、および動脈硬化指標等)に加えて、老化の表現系であるフレイルの評価項目に基づき、体組成分析・身体機能・身体活動量・精神状態に関するデータ収集を開始した。今後、社会因子としての経済指標や医療リテラシーに関する指標、介護度なども収集可能か検討している。
    循環白血球に取り込まれた細菌由来のDNA断片の解析については、NICE-GENEコホート研究における腸内細菌叢の変調の予備解析から、尿毒症などから惹起される酸性環境により炎症性の負担が増加することが一因で起こる腸内細菌叢の変調ではないかと推察した。 さらに、過去の報告と比較検討しこの腸内細菌叢の変調に推測される状況について、我々のコホートでの事例と合致するか検討を進める方針である。
    また、コントロールの検体収集として、おそらく約100名程度のサンプルが収集できる見込みである。
    国際共同研究施設であるカロリンスカ研究所、グラスゴー大学とは、COVID19パンデミック下、著しく交流が疎になっていたが、今後、国際学会などの機会を通じて情報交換を行い、循環白血球内のMicrobiomeの変調についてさらなる詳細な解析を行えるよう検討を継続していく。
    すでに開始してるコホート研究の患者登録については順調であるものの、循環白血球に取り込まれた細菌由来のDNA断片の解析については、すでに我々が予備解析に使用した健常人サンプルが、腎臓病患者サンプルと年齢構成があまりに異なり、検体数も少数であったため、比較検討がむずかしいことがわかった。そのため、新たに同年代の日本健常人の対照者によるサンプルの収集を開始している。
    腸内細菌叢の変調と細胞老年マーカーについて、テロメア長との検討を予定していた。しかしながら、共同研究者グラスゴー大学のProf. Paul Shielsより、我々が今まで行ってきたテロメア測定法によるテロメア長の解析よりCDKN2Aの評価のほうが、細胞老化を検討するにはSensitiveではないかとの指摘をいただき、予算やサンプルのクオリティも含めて実施可能か検討している。
    NICE-GENEコホート研究、RRTRコホート研究、N-KDRG研究いずれも、患者登録、サンプル収集、臨床情報収集を継続する。慢性腎臓病の初期の患者、さらに慢性腎臓病をきたしうる危険因子を持つ患者についても検討できると、慢性腎臓病の発症、進展、末期腎不全となってからの合併症にいたるまで、患者生涯をカバーするserialな経過を追うことができる。これが可能であれば、慢性腎臓病患者の老化を解明する当研究において研究目的を解明するために有用であると考えられる。
    また、循環白血球に取り込まれた細菌由来のDNA断片の解析については、細菌叢の変調は予想より多彩であった。細菌叢の変調の解釈についてすでに確立されたものが少なく、患者の表現系にどのように影響しているかについて報告するのに注意が必要であり、過去報告や共同研究機関でのデータとも比較し検討を続けていく。
    海外の研究者の興味は、日本人の慢性腎臓病患者の生存を含めた治療成績が欧米に比し良好であることが、日本食に起因しているのではないかというClinical Questionに基づいており、可能であれば食事に関する(とくに日本独特の発酵食品や魚介類の摂取)について追加情報を取得できないか検討していく方針である。

  2. Changes of microbiome in patients with chronic kidney disease and new therapeutic strategy by their improvement

    Grant number:19K08700  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kato Sawako

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    We analyzed bacterial DNA fragments in the circulating leukocytes collected from the patients who had just started dialysis therapy and one year after dialysis initiation. The bacterial strains in the circulating leukocytes at the start of dialysis differed greatly according to the primary disease of renal failure (diabetes mellitus, polycystic kidney, nephrosclerosis, chronic nephritis). There was no difference in bacterial strains between diabetic and non-diabetic, or patients with and without a history of cardiovascular disease.Next, we compared the bacterial genera among patients at the start dialysis, those one year after the start of dialysis therapy and healthy subjects. We found the difference in key bacterial genera involved with induction of inflammation between dialysis patients and healthy subjects. In addition, there was a correlation between the increase in serum calcium levels at the start of dialysis and the growth of Bacillus bacteria.

  3. Development of novel antihypertensive therapy with tissue protection in renal and cardiovascular diseases through elucidation of MK-EETs blood pressure regulation mechanism

    Grant number:16K09609  2016.4 - 2019.3

    Kato sawako

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    In a system aiming at deep observation of the living body using multiphoton confocal laser microscope A1R MP (Nikon), administration of epoxy eicosatrienoic acids (EETs) inhibitor and adenosine inhibitor, induced the vasoconstrictive action in Midkine (MK) deficient mice. The blood vessels were contracted and blood flow was decreased, as blood pressure increased. The blood flow rate was rising. On the other hand, when a nicotinic acetylcholine receptor inhibitor was administered to evaluate the sympathetic nervous system, blood pressure dropped in MK deficient mice, indicating an increase in blood flow. MK has been shown to regulate renal and blood pressure via a vasodilator.