Updated on 2024/03/15

写真a

 
ABE Kazuhiro
 
Organization
Cellular and Structural Physiology Institute Division Associate professor
Graduate School
Graduate School of Pharmaceutical Sciences
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 博士(理学) ( 2004.3   北海道大学 ) 

Research Interests 1

  1. 膜タンパク質 極低温電子顕微鏡 胃 プロトンポンプ P-type ATPase

Research Areas 5

  1. Life Science / Molecular biology

  2. Life Science / Functional biochemistry

  3. Life Science / Structural biochemistry

  4. Life Science / Biophysics

  5. Life Science / Pharmaceutical chemistry and drug development sciences

Research History 6

  1. Nagoya University   Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Structural Biology

    2012.4

  2. 京都大学 特定研究員

    2011.4 - 2012.3

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    Country:Japan

  3. 社団法人バイオ産業情報化コンソーシアム

    2008.4 - 2011.3

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    Country:Japan

  4. 日本学術振興会特別研究員 (PD)

    2005.4 - 2008.3

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    Country:Japan

  5. 日本学術振興会特別研究員 (PD)

    2004.4 - 2005.3

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    Country:Japan

  6. 日本学術振興会 特別研究員 (DC2)

    2003.4 - 2004.3

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    Country:Japan

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Education 3

  1. Hokkaido University   Graduate School, Division of Natural Science

    2001.4 - 2004.4

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    Country: Japan

  2. Hokkaido University   Graduate School, Division of Natural Science

    1999.4 - 2001.3

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    Country: Japan

  3. Hokkaido University   Faculty of Science

    1995.4 - 1999.3

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    Country: Japan

Professional Memberships 2

  1. 日本生化学会

  2. The Biophysical Society of Japan

Awards 5

  1. 日本生化学会奨励賞

    2013.9   日本生化学会  

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    Country:Japan

  2. 若手奨励賞

    2011.12   生体エネルギー研究会  

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    Country:Japan

  3. JBC Herbert Tabor Award

    2011.10   ASBMB  

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    Country:United States

  4. Margrethe Moller Award

    2008.8   P-ATPase conference  

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    Country:Denmark

  5. FASEB SRC Young Scientist Award

    2004.8   FASEB  

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    Country:United States

 

Papers 42

  1. Crystal structures of the gastric proton pump Reviewed International coauthorship

    Abe Kazuhiro, Irie Katsumasa, Nakanishi Hanayo, Suzuki Hiroshi, Fujiyoshi Yoshinori

    NATURE   Vol. 556 ( 7700 ) page: 214-+   2018.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41586-018-0003-8

    Web of Science

  2. A Na pump with reduced stoichiometry is up- regulated by brine shrimp in extreme salinities

    Artigas, P; Meyer, DJ; Young, VC; Spontarelli, K; Eastman, J; Strandquist, E; Rui, H; Roux, B; Birk, MA; Nakanishi, H; Abe, K; Gatto, C

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 120 ( 52 )   2023.12

  3. Deep learning driven de novo drug design based on gastric proton pump structures Reviewed

    Kazuhiro Abe, Mami Ozako, Miki Inukai, Yoe Matsuyuki, Shinnosuke Kitayama, Chisato Kanai, Chiaki Nagai, Chai C. Gopalasingam, Christoph Gerle, Hideki Shigematsu, Nariyoshi Umekubo, Satoshi Yokoshima & Atsushi Yoshimori

    Communications Biology   Vol. 6 ( 956 )   2023.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1038/s42003-023-05334-8

  4. An unusual conformation from Na+-sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na+-binding Reviewed International coauthorship

    Abe, K., Nishizawa, T. & Artigas, P.

    Biochim. Biophys. Acta–Mol. Cell Res.     2023.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbamcr.2023.119543

  5. 2. Three structures of PSI-LHCI from Chlamydomonas reinhardtii suggest a resting state re-activated by ferredoxin Reviewed International coauthorship

    Gerle, C., Misumi, Y., Kawamoto, A., Tanaka, H., Kawai-Kubota, H., Tokutsu, R., Kim, E., Chorev, D., Abe, K., Robinson, C.V., Mitsuoka, K., Minagawa, J., & *Kurisu, G.

    Biochim. Biophys. Acta–Bioenergetics   Vol. 1864 ( 4 )   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbabio.2023.148986

    Web of Science

  6. Dissecting movement of the transmembrane segments of non-gastric proton pump mutants with voltage-clamp fluorometry

    Self Daniel, Young Victoria C., Nakanishi Hanayo, Abe Kazuhiro, Artigas Pablo

    BIOPHYSICAL JOURNAL   Vol. 122 ( 3 ) page: 529A - 529A   2023.2

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  7. Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms Reviewed International coauthorship

    Young Victoria C., Nakanishi Hanayo, Meyer Dylan J., Nishizawa Tomohiro, Oshima Atsunori, Artigas Pablo, Abe Kazuhiro

    NATURE COMMUNICATIONS   Vol. 13 ( 1 )   2022.9

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-022-32793-0

    Web of Science

  8. Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump Reviewed International coauthorship

    Tanaka Saki, Morita Mikio, Yamagishi Tatsuya, Madapally Hridya Valia, Hayashida Kenichi, Khandelia Himanshu, Gerle Christoph, Shigematsu Hideki, Oshima Atsunori, Abe Kazuhiro

    JOURNAL OF MEDICINAL CHEMISTRY   Vol. 65 ( 11 ) page: 7843 - 7853   2022.6

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jmedchem.2c00338

    Web of Science

  9. Cryo-EM of the ATP11C flippase reconstituted in Nanodiscs shows a distended phospholipid bilayer inner membrane around transmembrane helix 2 Reviewed

    Nakanishi H, Hayashida K, Nishizawa T, Oshima A and Abe K

    Journal of Biological Chemistry   Vol. 298   page: 101498   2022.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.jbc.2021.101498

  10. Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations Reviewed

    Abe Kazuhiro, Yamamoto Kenta, Irie Katsumasa, Nishizawa Tomohiro, Oshima Atsunori

    NATURE COMMUNICATIONS   Vol. 12 ( 1 )   2021.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-021-26024-1

    Web of Science

  11. 細胞膜リン脂質フリッパーゼATP11Cの立体構造と輸送機構 Invited

    中西華代 阿部一啓

    生化学   Vol. 93 ( 6 ) page: 824 - 829   2021

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    Authorship:Last author, Corresponding author  

    DOI: 10.14952/SEIKAGAKU.2021.930824

  12. Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM Reviewed

    Nakanishi Hanayo, Nishizawa Tomohiro, Segawa Katsumori, Nureki Osamu, Fujiyoshi Yoshinori, Nagata Shigekazu, Abe Kazuhiro

    CELL REPORTS   Vol. 32 ( 13 )   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2020.108208

    Web of Science

  13. Crystal structure of a human plasma membrane phospholipid flippase Reviewed

    Nakanishi Hanayo, Irie Katsumasa, Segawa Katsumori, Hasegawa Kazuya, Fujiyoshi Yoshinori, Nagata Shigekazu, Abe Kazuhiro

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 295 ( 30 ) page: 10180 - 10194   2020.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.RA120.014144

    Web of Science

  14. Isoform-selective regulation of mammalian cryptochromes Reviewed

    Miller Simon, Son You Lee, Aikawa Yoshiki, Makino Eri, Nagai Yoshiko, Srivastava Ashutosh, Oshima Tsuyoshi, Sugiyama Akiko, Hara Aya, Abe Kazuhiro, Hirata Kunio, Oishi Shinya, Hagihara Shinya, Sato Ayato, Tama Florence, Itami Kenichiro, Kay Steve A., Hatori Megumi, Hirota Tsuyoshi

    NATURE CHEMICAL BIOLOGY   Vol. 16 ( 6 ) page: 676 - +   2020.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41589-020-0505-1

    Web of Science

  15. Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore Reviewed

    Urbani Andrea, Giorgio Valentina, Carrer Andrea, Franchin Cinzia, Arrigoni Giorgio, Jiko Chimari, Abe Kazuhiro, Maeda Shintaro, Shinzawa-Itoh Kyoko, Bogers Janna F. M., McMillan Duncan G. G., Gerle Christoph, Szabo Ildiko, Bernardi Paolo

    NATURE COMMUNICATIONS   Vol. 10   2019.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-019-12331-1

    Web of Science

  16. A single K+-binding site in the crystal structure of the gastric proton pump Reviewed International coauthorship

    Yamamoto Kenta, Dubey Vikas, Irie Katsumasa, Nakanishi Hanayo, Khandelia Himanshu, Fujiyoshi Yoshinori, Abe Kazuhiro

    ELIFE   Vol. 8   2019.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.47701

    Web of Science

  17. K+ binding and proton redistribution in the E2P state of the H+, K+-ATPase Reviewed International coauthorship

    Dubey Vikas, Han Minwoo, Kopec Wojciech, Solov'yov Ilia A., Abe Kazuhiro, Khandelia Himanshu

    SCIENTIFIC REPORTS   Vol. 8   2018.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-30885-w

    Web of Science

  18. The Elusive Proton in the Gastric Proton Potassium ATPase

    Dubey Vikas, Abe Kazuhiro, Solov'yov Ilia, Khandelia Himanshu

    BIOPHYSICAL JOURNAL   Vol. 114 ( 3 ) page: 146A - 146A   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bpj.2017.11.822

    Web of Science

  19. The cryo-EM structure of gastric H+, K+-ATPase with bound BYK99, a high-affinity member of K+-competitive, imidazo[1,2-a]pyridine inhibitors

    Abe Kazuhiro, Shimokawa Jun, Naito Mao, Munson Keith, Vagin Olga, Sachs George, Suzuki Hiroshi, Tani Kazutoshi, Fujiyoshi Yoshinori

    SCIENTIFIC REPORTS   Vol. 7   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-06698-8

    Web of Science

  20. The cryo-EM structure of gastric H+,K+-ATPase with bound BYK99, a high-affinity member of K+-competitive, imidazo[1,2-a] pyridine inhibitors Reviewed

    Kazuhiro Abe, Jun Shimokawa, Mao Naito, Keith Munson, Olga Vagin, George Sachs, Hiroshi Suzuki, Kazutoshi Tani, Yoshinori Fujiyoshi

    Scientific Reports   Vol. 7   page: 6632   2017.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI:10.1038/s41598-017-06698-8

  21. Cryo-electron microscopy for structure analyses of membrane proteins in the lipid bilayer Invited Reviewed

    Abe K. & Fujiyoshi Y

    Current Opinion in Structural Biology   Vol. 39   page: 71-78   2016.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.sbi.2016.06.001

  22. Systematic comparison of molecular conformations of H+,K+-ATPase reveals an important contribution of the A-M2 linker for the luminal gating. Reviewed

    Abe, K., Tani, K., Fujiyoshi, Y.

    J. Biol. Chem.   Vol. 289 ( 44 ) page: 30590-30601   2014.9

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  23. Biochemical and electron crystallographic studies of gastric proton pump Invited

    Abe, K.

      Vol. 86 ( 4 ) page: 429-440   2014.8

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    Authorship:Lead author   Language:Japanese  

  24. 1. The four-transmembrane protein IP39 of Euglena forms strands by a trimeric unit repeat Reviewed

    Suzuki, H., Ito, Y., Yamazaki, Y., Mineta, K., Uji, M., Abe, K., Tani, K., Fujiyoshi, Y. & Tsukita, S.

    Nature Communications   Vol. 4   page: 1766   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  25. Carbon sandwich preparation preserves quality of two-dimensional crystals for cryo-electron microscopy Reviewed

    Yang F., Abe, K., Tani K., Fujiyoshi Y.

    Microscopy   Vol. 62   page: 597-606   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  26. Cryo-EM structure of gastric H+,K+-ATPase with a single occupied cation-binding site Reviewed

    Abe, K., Tani, K., Friedrich, T.& Fujiyoshi, Y.

    Proceedings of the National Academy of Sciences USA   Vol. 109 ( 45 ) page: 18401-18406   2012.11

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  27. Unique properties of gastric H+,K+-ATPase and conserved conformational changes among P-type ATPases

    Abe, K.

      Vol. 84   page: 115-119   2012.2

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    Language:Japanese  

  28. Conformational rearrangement of gastric H+,K+-ATPase with an acid suppressant.

    Abe, K., Tani, K. & Fujiyoshi, Y.

    Nature Communications   Vol. 2 ( 155 ) page: 1-9   2011.1

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  29. A novel ratchet mechanism of gastric H+,K+-ATPase revealed by electron crystallography of two-dimensional crystals.

    Abe, K., Tani, K., Nishizawa, T. & Fujiyoshi, Y.

      Vol. 130   page: 205-210   2010

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    Language:Japanese  

  30. Structural analysis of gastric proton pump by cryo-electron microscopy.

    Abe, K.

      Vol. 45   page: 264-267   2010

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    Language:Japanese  

  31. Structural and functional characterization of H+,K+-ATPase with bound fluorinated phosphate analogs.

    Abe, K., Tani, K. & Fujiyoshi, Y.

    Journal of Structural Biology   Vol. 170   page: 60-68   2010

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  32. Epigallocatechin-3-gallate is an inhibitor of Na+,K+-ATPase by favoring the E1 conformation.

    Ochiai, H., Takeda, K., Soeda, S., Tahara, Y., Takenaka, H., Abe, K., Hayashi, Y., Noguchi, S., Inoue, M., Schwarz, S., Schwarz, W. & Kawamura, M.

    Biochemical Phamacology   Vol. 78   page: 1069-1074   2009

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  33. Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle.

    Abe, K., Tani, K., Nishizawa, T. & Fujiyoshi, Y.

    EMBO Journal   Vol. 28   page: 1637-1643   2009

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  34. E2P state stabilization by the N-terminal tail of the H,K-ATPase beta-subunit is critical for efficient proton pumping under in vivo conditions.

    Dürr, K., Abe, K., Tavraz, N.N. & Friedrich, T.

    Journal of Biological Chemistry   Vol. 284   page: 20147-20154   2009

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  35. Structural analysis of 2D crystals of gastric H+,K+-ATPase in different states of the transport cycle.

    Nishizawa, T., Abe, K., Tani, K. & Fujiyoshi, Y.

    Journal of Structural Biology   Vol. 162   page: 219-228   2008

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  36. Relationship between activity and tetraprotomeric structure of ion-transporting ATPases.

    Abe, K., & Kaya, S.

      Vol. 79   page: 527-534   2007

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    Language:Japanese  

  37. New evidence for ATP binding induced catalytic subunit interactions in pig kidney Na/K-ATPase.

    Tanoue, K., Kaya, S., Hayashi, Y., Abe, K., Imagawa, T., Taniguchi, K. & Sakaguchi, K.

    Journal of Biochemistry   Vol. 140   page: 599-607   2006

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  38. Evidence for a relationship between activity and the tetraprotomeric assembly of solubilized pig gastric H/K-ATPase.

    Abe, K., Kaya, S., Taniguchi, K., Hayashi, Y., Imagawa, T., Kikumoto, M., Oiwa, K. & Sakaguchi, K.

    Journal of Biochemistry   Vol. 138   page: 293-301   2005

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  39. Correlation between the activities and the oligomeric forms of pig gastric H/K-ATPase.

    Abe, K., Kaya, S., Hayashi, Y., Imagawa, T., Kikumoto, M., Oiwa, K., Katoh, T., Yazawa, M. & Taniguchi, K.

    Biochemistry   Vol. 42   page: 15132-15138   2003

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  40. Gastric H/K-ATPase liberates two moles of Pi from one mole of phosphoenzyme formed from a high-affinity ATP binding site and one mole of enzyme-bound ATP at the low-affinity site during cross-talk between catalytic subunits.

    Abe, K., Kaya, S., Imagawa, T. & Taniguchi, K.

    Biochemistry   Vol. 41   page: 2438-2445   2002

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  41. The oligomeric nature of Na/K-transport ATPase

    Taniguchi, K, Kaya, S., Abe, K. & Mårdh, S.

    Journal of Biochemistry   Vol. 129   page: 335-342   2001

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  42. Acid-labile ATP and/or ADP/Pi binding to the tetraprotoemeric form of Na/K-ATPase accompanying catalytic phosphorylation-dephosphorylation cycle.

    Yokoyama, T., Kaya, S., Abe, K., Taniguchi, K., Katoh, T., Yazawa, M., Hayashi, Y. & Mårdh, S.

    Journal of Biological Chemistry   Vol. 274   page: 31792-31796   1999

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Books 2

  1. Methods in Molecular Biology, P-type ATPases, 4 Isoration of H+,K+-ATPase-enriched membrane fraction from pig stomach

    ( Role: Joint author)

    Springer  2016.1  ( ISBN:978-1-4939-3178-1

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    Language:English

  2. Methods in Molecular Biology, P-type ATPases, 39 Two-dimensional crystallization of gastric H+,K+-ATPase for structural analysis by electron crystallography

    Abe K( Role: Sole author)

    Springer  2016.1  ( ISBN:978-1-4939-3178-1

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    Language:English

Presentations 86

  1. カチオン能動輸送体の構造生理学と創薬 Invited

    阿部一啓

    第101回日本生理学会大会  2024.3.28 

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    Event date: 2024.3

    Language:English   Presentation type:Oral presentation (invited, special)  

  2. 細胞膜リン脂質フリッパーゼの構造と輸送機構. Invited

    阿部一啓

    第96回日本生化学会大会  2023.10.31 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  3. 胃酸抑制剤のターゲット 胃プロトンポンプの構造生理学研究 Invited

    阿部一啓

    国際医療福祉大学公開講演会  2023.10.29 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (keynote)  

  4. 2. Structural Physiology of P-type ATPases that generate asymmetric distribution of substrate across the membrane. Invited International conference

    Kazuhiro Abe

    Biological Chemistry on Membrane – Understanding and Engineering  2023.8.30 

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    Event date: 2023.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Kyoto  

  5. 3. Structural Physiology of P-type ATPases that Generate Asymmetric Distribution of Cations and Phospholipids. Invited International conference

    Kazuhiro Abe

    International Conference on Biological Physics 2023  2023.8.15 

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    Event date: 2023.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Seoul   Country:Korea, Republic of  

  6. カチオン能動輸送体P2-type ATPaseの構造機能連関. Invited

    阿部一啓

    第23回日本タンパク質科学会年会  2023.7.7 

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    Event date: 2023.7

    Language:English   Presentation type:Oral presentation (invited, special)  

  7. 5. プロトンポンプの構造生理学とナトリウムポンプ型変異体の作成 Invited

    阿部一啓

    第17回トランスポーター研究会  2023.5.27 

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    Event date: 2023.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  8. ナトリウムポンプのつくりかた Invited

    阿部一啓

    日本薬学会第143年会  2023.3.28 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  9. ナトリウムポンプのつくりかた Invited

    阿部一啓

    日本生体エネルギー研究会 第48回討論会  2022.12.14 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  10. プロトンポンプ胃酸抑制剤結合構造のクライオ電顕構造解析 Invited

    阿部一啓

    第45回分子生物学会   2022.12.1 

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    Event date: 2022.11 - 2022.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  11. ナトリウムポンプのつくりかた

    阿部一啓

    第95回日本生化学会大会   2022.11.9 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋   Country:Japan  

  12. Crystal and cryo-EM structures of cation-transporting P-type ATPase Invited International conference

    Kazuhiro Abe

    Frontier of Dynamic Structural Biology  2022.10.17 

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    Event date: 2022.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Osaka   Country:Japan  

  13. How to make a Na+ pump Invited International conference

    Kazuhiro Abe

    The 60th Annual Meeting of the Biophysical Society of Japan  2022.9.28 

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    Event date: 2022.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Hakodate   Country:Japan  

  14. Structural Physiology of the Gastric Proton pump and the Lipid Flippase Invited International conference

    Kazuhiro Abe

    2022.9.15 

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    Event date: 2022.9

    Language:English   Presentation type:Oral presentation (keynote)  

    Country:United States  

  15. Structural Physiology of the Gastric Proton pump and the Lipid Flippase Invited International conference

    Kazuhiro Abe

    P-Type ATPases in Health and Disease  2022.9.8 

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    Event date: 2022.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Banff   Country:Canada  

  16. 胃酸抑制剤のターゲット・胃プロトンポンプの構造生物化学 Invited

    阿部一啓

    創薬談話会2022  2022.6.30 

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    Event date: 2022.6 - 2022.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  17. 胃プロトンポンプの分子構造が解き明かす胃強酸性化の分子メカニズムと胃酸抑制剤結合構造基盤 Invited

    阿部一啓

    PPIの基礎と臨床(講演会)  2022.2.21  武田薬品工業

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    Event date: 2022.2

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:松戸(Zoom)  

  18. 2つのK+を結合した胃プロトンポンプ変異体 Invited

    阿部一啓

    日本生体エネルギー研究会第47回討論会 理研シンポジウム「輸送とエネルギー」  2021.12.17 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  19. Primary transporters that generate asymmetric distribution of cation and phospholipid Invited International conference

    Kazuhiro Abe

    3rd Research Meeting on Cell Dynamics, iCeMS  2021.11.24  ICeSM, Kyoto University

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    Event date: 2021.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  20. 膜輸送体の構造生理学 Invited

    阿部一啓

    北海道大学生物化学特別講演  2021.11.12 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (keynote)  

  21. Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations Invited International conference

    Kazuhiro Abe

    The 94th Annual Meeting of the Japan Biochemical Society "Membrane transport proteins- listin to their quiet whisper while standing on the shoulders of the giants-"  2021.11.3 

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    Event date: 2021.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  22. 胃の酸性化の分子機構 Invited

    阿部一啓

    第42回生体膜と薬物の相互作用シンポジウム  2021.10.29 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  23. 胃の酸性化のメカニズム Invited

    阿部一啓

    第69回SPring8先端利用ワークショップ  2021.9.21 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (keynote)  

  24. 細胞膜フリッパーゼATP11Cによる脂質輸送メカニズム

    阿部一啓

    生理研研究会 構造情報を基盤とした膜機能分子の整理機能理解へ向けて  2021.9.7 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  25. 『細胞死を司るポンプ』脂質フリッパーゼATP11Cの結晶構造とCryo-EM構造

    阿部一啓

    日本生体エネルギー研究会第46回討論会 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  26. 細胞膜フリッパーゼATP11Cの構造機能解析

    阿部一啓

    第93回日生化学会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜(Zoom)   Country:Japan  

  27. Crystal structures of the gastric proton pump - molecular basis for the binding of acid suppressants, H+-extrusion and K+-counter-transport

    Kazuhiro Abe

     More details

    Event date: 2020.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  28. Structural basis of the proton extrusion mechanism of the gastric proton pump Invited

    Kazuhiro Abe

     More details

    Event date: 2020.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  29. Molecular mechanisms for the drug binding, H+-extrusion and the K+ counter-transport Invited International conference

    Kazuhiro Abe

    Academia Sinica IBC seminar 

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    Event date: 2019.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Academia Sinica, Taipei   Country:Taiwan, Province of China  

  30. Crystal structure of the gastric proton pump Invited International conference

    Kazuhiro Abe

    World Laureates Forum 2nd conference 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

    Venue:Shanghai, China   Country:China  

  31. X線結晶学とクライオ電顕で得られた構造情報の上手な活用法 ~胃プロトンポンプの構造解析を例として~ Invited International conference

    阿部一啓

    2019年度生理研研究会 

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    Event date: 2019.9 - 2019.10

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:大阪   Country:Japan  

  32. 胃プロトンポンプの輸送機構に対する構造基盤 Invited International conference

    阿部一啓

    生物物理第57回年会 台湾‐日本 二国間シンポジウム:X線結晶構造解析とクライオ電顕2019 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:宮崎   Country:Japan  

  33. Structural basis for the H+-extrusion and the K+-occlusion of the gastric proton pump Invited International conference

    Abe K

    Society of General Physiology /SOBLA 2019 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Valparaiso, Chile   Country:Chile  

  34. Crystal structure of the gastric proton pump International conference

    Kazuhiro Abe, Kenta Yamamoto, Katsumasa Irie, Hanayo Nakanishi, Yoshinori Fujiyoshi

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    Event date: 2019.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Colby Sawyer, NH, USA   Country:United States  

  35. 胃の強酸性化の分子メカニズム ‐胃プロトンポンプの結晶構造解析 Invited

    阿部一啓

    日本生体エネルギー研究会 第44回討論会 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:千葉大学   Country:Japan  

  36. Crystal structures of the gastric proton pump Invited International conference

    Kazuhiro Abe

    AsCA2018 

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    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Auckland, NZ   Country:Japan  

  37. 1. 胃プロトンポンプの結晶構造によって明らかになったH+排出機構 Invited

    阿部一啓

    大阪大学蛋白質研究所セミナー 構造生物学と計算科学の融合による動的構造生物学の新しい展開  

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  38. 胃プロトンポンプの結晶構造 International conference

    阿部一啓

    第91回日本生化学会大会 シンポジウム 生化学から広がる膜輸送体研究の深化, 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  39. 3. 胃の強酸性化の秘密 Invited

    阿部一啓

    創薬等ライフサイエンス研究支援基盤事業 平成30年度BINDS公開 シンポジウム「知って、使って、進む あなたの研究」 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  40. 4. 胃プロトンポンプの構造生理学~胃酸に対してプロトンを押し出すメカニズム~ Invited

    阿部一啓

    大阪大学蛋白質研究所セミナー 構造情報に基づいた膜イオン輸送タ ンパク質の生理機能の解明に向けて 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  41. Structural basis for the H+ extrusion and the transport stoichiometry of the gastric proton pump Invited

    Kazuhiro Abe

    Frontiers in P-type ATPase Research 2018, Institute for Quantitative Bioscience 

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:The University of Tokyo   Country:Japan  

  42. Crystal structure of the gastric proton pump at 2.8A resolution

    Kazuhiro Abe

     More details

    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  43. Structural and functional analysis of gastric proton pump and acid suppressants

    Kazuhiro Abe

    ConBio2017 

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    Event date: 2017.12

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  44. Structural and functional analysis of gastric H+,K+-ATPase Invited International conference

    The 15th international conference on Na,K-ATPase and related transport ATPases 

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Otsu, Japan   Country:Japan  

  45. 胃プロトンポンプの構造生理学 Invited

    阿部一啓

    日本物理学会 第72回年次大会 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:大阪大学   Country:Japan  

  46. Binding model of the acid suppressant to the gastric proton pump Invited

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:筑波   Country:Japan  

  47. 日本生化学会 Invited

    阿部一啓

    第89回日本生化学会大会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東北大学   Country:Japan  

  48. 電子線結晶学と機能解析に基づいた胃プロトンポンプの構造生理学 Invited

    阿部一啓

    大阪大学蛋白質研究所セミナー 『膜タンパク質の構造ダイナミクス』 Structural dynamics of membrane proteins 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:大阪大学   Country:Japan  

  49. 胃プロトンポンプの構造生理学 Invited

    阿部一啓

    千里ライフサイエンスセミナーK2 トランスポーターと創薬~構造と病態からのアプローチ~ 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:千里ライフサイエンスセンタービル 5階 山村雄一記念ライフホール   Country:Japan  

  50. Electron crystallographic analysis of gastric proton pump

    Kazuhiro Abe

    IPR Seminar "Introduction and overview of cryo-electron microscopy" 

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    Event date: 2016.2

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  51. 胃H+,K+-ATPaseの 胃酸抑制剤結合状態についての考察

    阿部一啓

    日本生体エネルギー研究会 第41回 討論会 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  52. Mutational analysis of acid surppressant binding site of gastric proton pump based on its structural model

    Kazuhiro ABE, Kazutoshi Tani, Mao Naito, Jun Shimokawa, Yoshinori Fujiyoshi

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    Event date: 2015.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  53. Antagonist-bound structure of gastric proton pump

    Abe K

     More details

    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  54. Structural physiology of gastric proton pump International conference

    Denmark-Japan Joint Workshop on Ion Transport Proteins 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  55. Electron crystallographic and mutational analysis of acid suppressant-bound gastric proton pump

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    Event date: 2015.5 - 5015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  56. Systematic comparison of the molecular conformation of gastric H+,K+-ATPase in E2P state analogs

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    Event date: 2014.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  57. 胃プロトンポンプH+,K+-ATPaseの構造生理学

    阿部一啓

    第3回 九州地区 生理薬理系研究会 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Country:Japan  

  58. Electron crystallographic analysis of gastric proton pump

    Abe, K.

    JEM Next-Generation Microscopic Science 

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    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  59. Systematic comparison of the molecular conformation of gastric H+,K+-ATPase in E2P state analogs

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  60. Structural and biochemical analysis of gastric H+,K+-ATPase in E2P-analogue conformations International conference

    Abe, K.

    ASBMB Special symposia, Na,K-ATPase and related transport ATPases: Structure, Mechanism, Cell Biology, Health and Disease 

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    Event date: 2014.8 - 2014.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Netherlands  

  61. 胃プロトンポンプの構造生理学 International conference

    阿部一啓

    第9回トランスポーター研究会 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  62. 胃プロトンポンプの阻害剤結合構造から見えてきたE2P遷移状態における構造変化

    阿部一啓

    日本生体エネルギー研究会第39回討論会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:静岡   Country:Japan  

  63. 胃プロトンポンプの極低温電子顕微鏡による構造解析

    阿部一啓

    第4回神経科学と構造生物学の融合研究会 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:岡崎コンファレンスセンター   Country:Japan  

  64. 電子顕微鏡のイメージから膜タンパク質の立体構造を再構成する~胃プロトンポンプの例を中心として~

    阿部一啓

    分析化学会中部支部愛知地区講演会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋大学   Country:Japan  

  65. Biochemical and electron crystallographic studies of gastric proton pump

    Kazuhiro Abe

    The 86th Annual Meeting of the Japanese Biochemical Society 

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    Event date: 2013.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  66. 胃プロトンポンプの生化学と電子線結晶構造解析

    阿部一啓

    第86回日本生化学会 奨励賞受賞講演 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:横浜   Country:Japan  

  67. Cryo-EM structures of gastric proton pump International conference

    Abe K

    FAOBMB mini-symposium 

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    Event date: 2013.4

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  68. Unique properties and conserved conformational changes found in gastric H+,K+-ATPase International conference

    Abe K, Tani K and Fujiyoshi Y

    Nagoya Symposium 

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    Event date: 2013.1

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  69. 電子線結晶学による胃プロトンポンプの立体構造解析 International conference

    阿部一啓

    生体エネルギー研究会第38回討論会 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:岡山大学   Country:Japan  

  70. 胃H+,K+-ATPaseの逆反応防止機構とその解除-- (K+)E2~P構造を中心として

    阿部一啓

    生体エネルギー研究会 第37回討論会 

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都産業大学 京都  

  71. Unique structures and conserved conformational changes found in gastric H+,K+-ATPase International conference

    Kazuhiro Abe

    2011 ASBMB sepcial symposia, Na/K-ATPase and related P-ATPases 

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    Event date: 2011.9 - 2011.10

    Language:English   Presentation type:Oral presentation (invited, special)  

  72. 電子線結晶学によって明らかになった胃H+,K+-ATPaseのユニークな構造とP型ATPaseファミリー間で保存された構造変化

    阿部一啓

    第84回日本生化学会大会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都国際会議場 京都  

  73. Conformational rearrangement of gastric H+,K+-ATPase induced by an acid suppressant International conference

    Kazuhiro Abe

    Direct imaging in Bio/Medical science 

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    Event date: 2011.1

    Language:English   Presentation type:Poster presentation  

  74. Three-dimensional structure of gastric H+,K+-ATPase with unti-ulcer drug International conference

    Kazuhiro Abe

    FASEB SRC, transport ATPase 

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    Event date: 2010.6

    Language:English   Presentation type:Oral presentation (general)  

  75. 電子線結晶学により明らかになった胃プロトンポンプの逆反応防止機構

    阿部一啓

    生体エネルギー研究会 第35回討論会 

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    Event date: 2009.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:旭川医科大学  

  76. 胃プロトンポンプのサブユニット間相互作用による逆反応防止機構

    阿部一啓

    第82回日本生化学会大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:神戸国際会議場  

  77. A Novel Ratchet Mechanism of Gastric H+,K+-ATPase Revealed by Cryo-Electron Microscopy

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    Event date: 2009.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  78. A Novel Ratchet Mechanism of Gastric H+,K+-ATPase Revealed by Electron Crystallography of Two-Dimensional Crystals

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    Event date: 2009.1

    Language:Japanese   Presentation type:Oral presentation (general)  

  79. Three-dimensional structure of gastric H/K-ATPase at 6.5 Å resolution determined by electron crystallography of two-dimensional crystals International conference

    Kazuhiro Abe, Kazutoshi Tani, Tomohiro Nishizawa, Yoshinori Fujiyoshi

    17th Meeting of Methods in Protein Structure Analysis (MPSA2008)  

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    Event date: 2008.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  80. Structure of gastric H+,K+-ATPase at 8-Å resolution International conference

    Kazuhiro Abe

    12th International PATPase conference, Na,K-ATPase and Related Transport ATPases 

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    Event date: 2008.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  81. Structural Analysis of 2D crystals of Gastric H+, K+-ATPase in different states of the transport cycle

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    Event date: 2007.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  82. Two-dimensional crystallization of pig gastric H/K-ATPase International conference

    Kazuhiro Abe, Tomohiro Nishizawa, Kazutoshi Tani, Yoshinori Fujiyoshi

    The 16th International Microscopy Congress 

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    Event date: 2006.9

    Language:English   Presentation type:Poster presentation  

  83. Two-dimensional Crystallografic Study of Pig Gastric H/K-ATPase International conference

    Kazuhiro Abe, Tomohiro Nishizawa, Kazutoshi Tani, Yoshinori Fujiyoshi

    IUBMB Cation pump meeting 

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    Event date: 2006.7

    Language:English   Presentation type:Poster presentation  

  84. K+-induced change in oligomeric assembly of C12E8-solubilized pig gastric H/K-ATPase observed by single-molecule detection technique. International conference

    Kazuhiro Abe, Shunji Kaya, Kazuyashu Sakaguchi, Toshiaki Imagawa, Yutaro Hayashi, Kazuya Taniguchi

    Na,K-ATPase & Related Cation Pumps 

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    Event date: 2005.9

    Language:English   Presentation type:Poster presentation  

  85. Investigation of tetraprotomeric structure of pig gastric H/K-ATPase based on single-molecule detection techniques International conference

    Abe K, Kaya S, Kikumoto M, Oiwa K, Katoh T, Yazawa M and Taniguchi K

    FASEB Summer Research Conference, Transport ATPases: Genomics to Mechanism and Releavnce to Diseases 

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    Event date: 2003.7

    Language:English   Presentation type:Oral presentation (general)  

  86. K+ induced simultaneous liberation of two moles of Pi one from mole of EP and the other from EATP of oligomeric H/K-ATPase from pig stomach International conference

    Kazuhiro Abe, Shunji Kaya, Toshiaki Imagawa, Kazuya Taniguchi

    10th International Conference on Na/K-ATPase and Related Cation Pumps 

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    Event date: 2002.8

    Language:English   Presentation type:Oral presentation (invited, special)  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 11

  1. 高次構造体連関が制御する脂質スクランブルシステム

    2022.10 - 2028.3

    CREST 

    阿部一啓

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\96000000

  2. 胃酸分泌の分子メカニズム解明と新規薬剤開発の為の構造基盤

    2018.11 - 2021.3

    武田科学振興財団   生命科学研究助成 

    阿部一啓

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\10000000

  3. 細胞膜におけるリン脂質の非対称分布とその崩壊

    2014.10 - 2020.3

    CREST 

    阿部一啓

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\51000000

  4. 構造・情報科学を駆使した新たな胃酸抑制剤の創生

    2023.1 - 2023.12

    第40回研究助成 

    阿部一啓

      More details

    Grant amount:\2000000

  5. カチオン能動輸送体の構造機能解析と機能獲得変異体による基質特異性の解明

    2021.4 - 2022.3

    第35回ノバルティス研究奨励金 

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000

  6. 『細胞死を司るポンプ』脂質フリッパーゼのリン脂質認識と輸送機構

    2021.3 - 2022.3

    公益財団法人 小野医学研究財団  2020年度 小野医学研究助成 

    阿部一啓

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000

  7. 細胞膜を隔てた物質非対称分布を作り出す能動輸送体の作動機構の解明

    2020.12 - 2022.3

    大幸財団 自然科学系学術研究助成 

    阿部一啓

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4000000

  8. 胃プロトンポンプを初めとしたヒト能動輸送体の構造機能解析と創薬への展開

    2019.12 - 2021.9

    内藤記念科学奨励金・研究助成 

    阿部一啓

      More details

    Grant type:Competitive

  9. 物質不均衡を司る能動輸送体の構造解析と創薬

    2019.12 - 2021.4

    上原記念生命科学財団 研究助成金 

    阿部一啓

      More details

    Grant type:Competitive

  10. クライオ電子顕微鏡のフィードバックに基づく膜タンパク質複合体の生産と技術支援

    2017.4 - 2022.3

    創薬等ライフサイエンス研究支援基盤事業 

    阿部一啓

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\275000000

  11. 多様な顕微鏡技術による膜タンパク質複合体の多階層での機能構造研究

    2012.10 - 2017.3

    創薬等支援技術基盤プラットフォーム補助金 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. 物質不均衡分布を司る能動輸送体P型ATPaseの構造機能生理学

    Grant number:21H02426  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(B)

    阿部 一啓

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    Authorship:Principal investigator 

    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

    生命の根幹とも言える細胞膜を隔てた物質不均衡分布は、主としてカチオンの能動輸送体(イオンポンプ)として知られるP型ATPaseファミリーによって作り出される。この中で、
    ・100万倍のH+濃度勾配を作り出す胃プロトンポンプ
    ・アポトーシスに関与するリン脂質フリッパーゼATP11C
    これら2つのユニークなポンプの作動機構解明を目指す。

  2. 胃プロトンポンプの構造生理学研究

    2017.4 - 2021.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  3. Structural physiology of the gastric proton pump

    Grant number:17H03653  2017.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Abe Kazuhiro

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    Authorship:Principal investigator 

    Grant amount:\17030000 ( Direct Cost: \13100000 、 Indirect Cost:\3930000 )

    We determined high-resolution structures of the gastric proton pump, which provide molecular basis of how this pump acidify our gastric juice down to pH 1 (Abe et al., 2018, Nature). We also determined K+-bound form of the proton pump to show unequivocally its transport stoichiometry (Yamamoto et al., 2019, eLife).
    We further determined crystal and cryoEM structures of phospholipid flippase, and revealed its molecular mechanisms.

  4. Studies in structural physiology of channels

    Grant number:15H05775  2015.5 - 2020.3

    FUJIYOSHI Yoshinori

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    Authorship:Coinvestigator(s) 

    Structural information of membrane proteins including channels is crucial toward gaining a better understanding of biologic functions. The information that can be gained from a protein structure strongly depends on its resolution - the higher the resolution, the more insight gained into the structure-function relationship of biologic macromolecules. We analyzed structures of proton pump, water channel AQP4, whose inhibitor could be a drug for brain edema, Na+ channel, gap junction channels and tight junction channels at high resolutions. While we could not get significant results of AChR, we analyzed structures of endothelin receptor and its complexes with the agonist and antagonists. In this project, we could get important knowledge in the research field named as structural physiology and partly elucidate how the channels work and regulate functions of the human body. We also contributed advancement of cryo-electron microscopy by developing cryo-electron microscopes.

  5. 最大級のイオン濃度勾配を形成する胃プロトンポンプ作動機構の解明

    2014.4 - 2018.3

    科学研究費補助金  若手研究(A)

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    Authorship:Principal investigator 

  6. 電子線結晶学と酵素化学的研究に基づいた胃プロトンポンプのユニークな作動機構の解明

    2012.4 - 2014.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  7. 4量体H/K-ATPaseの構造機能連関~4量体構造の生理的意義の解明~ (1701307)

    2006.4 - 2009.3

    科学研究費補助金 

    阿部 一啓

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    Authorship:Principal investigator 

  8. P型‐ATPaseの多量体構造と機能の相関 (1509844)

    2004.4 - 2006.3

    科学研究費補助金 

    阿部 一啓

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 37

  1. Introduction to Biochemistry III

    2020

  2. Structural Biology Research Course

    2020

  3. Molecular & Cellular Search and Production of Bioactive Factors

    2020

  4. Advanced Structural Biophysics

    2020

  5. Basic Training for Crossover Research

    2020

  6. 先端構造科学

    2018

  7. 多分野融合実践演習

    2018

  8. 多分野融合実践実習

    2018

  9. 創薬分子構造学実験

    2018

  10. 創薬分子構造学セミナー1B

    2018

  11. 創薬探索科学

    2018

  12. 創薬分子構造学セミナー1A

    2018

  13. 創薬分子構造学セミナー1B

    2017

  14. 創薬分子構造学セミナー1A

    2017

  15. 多分野融合実践演習

    2017

  16. 多分野融合実践実習

    2017

  17. 創薬分子構造学実験

    2017

  18. 創薬分子構造学セミナー1A

    2016

  19. 多分野融合実践演習

    2016

  20. 多分野融合実践実習

    2016

  21. 創薬分子構造学実験

    2016

  22. 創薬分子構造学セミナー1B

    2016

  23. 創薬分子構造学セミナー1A

    2015

  24. 多分野融合実践演習

    2015

  25. 多分野融合実践実習

    2015

  26. 創薬分子構造学実験

    2015

  27. 創薬分子構造学セミナー1B

    2015

  28. 創薬分子構造学セミナー1A

    2014

  29. 創薬分子構造学セミナー1B

    2014

  30. 創薬分子構造学実験

    2014

  31. 多分野癒合実践実習

    2014

  32. 多分野融合実践演習

    2014

  33. 多分野融合実践演習

    2013

  34. 創薬分子構造学実験

    2013

  35. 創薬分子構造学セミナー1B

    2013

  36. 創薬分子構造学セミナー1A

    2013

  37. 多分野癒合実践実習

    2013

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Teaching Experience (Off-campus) 5

  1. 分子細胞生物学

    2022.1 Ehime University)

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    Level:Undergraduate (specialized) 

  2. 化学特別講義(生物化学特別講義)

    2021.11 Hokkaido University)

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    Level:Postgraduate 

  3. 生命システム科学特別講義

    2021.9 Prefectural University of Hiroshima)

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    Level:Undergraduate (specialized) 

  4. 分子細胞生物学

    2021.1 Ehime University)

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    Level:Undergraduate (specialized) 

  5. 基盤物理化学特論

    2020.6 Kyoto University)

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    Level:Postgraduate 

 

Media Coverage 25

  1. AI創薬を活用した胃酸抑制剤の共同研究を開始 Newspaper, magazine

    科学新聞  2023.3

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    Author:Other 

  2. New study explains mechanisms of salt transport and could help treat cystic fibrosis Internet

    EurekAlert!  https://www.eurekalert.org/news-releases/965387  2022.9

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    Author:Other 

  3. New study explains mechanisms of salt transport and could help treat cystic fibrosis Internet

    PHYS.ORG  https://phys.org/news/2022-09-mechanisms-salt-cystic-fibrosis.html  2022.9

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    Author:Other 

  4. New study explains mechanisms of salt transport and could help treat cystic fibrosis Internet

    Bioengineer.org  https://bioengineer.org/new-study-explains-mechanisms-of-salt-transport-and-could-help-treat-cystic-fibrosis/  2022.9

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    Author:Other 

  5. Research explains mechanisms of salt transport and could help treat cystic fibrosis Internet

    MIRAGE  https://www.miragenews.com/research-explains-mechanisms-of-salt-transport-859128/  2022.9

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    Author:Other 

  6. New study explains mechanisms of salt transport and could help treat cystic fibrosis Internet

    SCIENMAG  https://scienmag.com/new-study-explains-mechanisms-of-salt-transport-and-could-help-treat-cystic-fibrosis/  2022.9

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    Author:Other 

  7. ナトリウムポンプのつくりかた Internet

    日本の研究.com  2022.9

  8. Binding structure analysis of gastric acid inhibitors ー Action of existing drugs revealed at the molecular level Internet

    2022.7

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    Author:Other 

  9. 胃酸抑制剤の結合構造解析 既存薬の作用 分子レベルで判明 名古屋大など成果 Newspaper, magazine

    科学新聞  2022.6

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    Author:Other 

  10. 胃酸抑制剤の結合構造を解析 ~胃酸抑制剤の論理的なドラッグデザインに道~ Internet

    日本の研究.com  2022.5

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    Author:Other 

  11. Unique underpinnings revealed for stomach’s acid pump Internet

    MIRAGE  https://www.miragenews.com/unique-underpinnings-revealed-for-stomachs-acid-652064/  2021.10

  12. Researchers improve understanding of molecular mechanisms underlying stomach’s acid pump Internet

    AZO life science  https://www.azolifesciences.com/news/20211015/Researchers-improve-understanding-of-molecular-mechanisms-underlying-stomache28099s-acid-pump.aspx  2021.10

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    Author:Other 

  13. Study reveals unique molecular mechanisms of stomach’s acid pump Internet

    News medical life science  https://www.news-medical.net/news/20211015/Study-reveals-unique-molecular-mechanisms-stomache28099s-acid-pump.aspx  2021.10

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    Author:Other 

  14. Unique underpinnings revealed for stomach’s acid pump Internet

    SCIENMAG  https://scienmag.com/unique-underpinnings-revealed-for-stomachs-acid-pump/  2021.10

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    Author:Other 

  15. Unique underpinnings revealed for stomach’s acid pump New understandings of a stomach enzyme could lead to better anti-ulcer drugs. Internet

    ScienceDaily  https://www.sciencedaily.com/releases/2021/10/211014100121.htm  2021.10

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    Author:Other 

  16. Unique underpinnings revealed for stomach's acid pump Internet

    Newsbreak  https://www.newsbreak.com/news/2402816116871-unique-underpinnings-revealed-for-stomach-s-acid-pump  2021.10

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    Author:Other 

  17. Unique underpinnings revealed for stomach's acid pump Internet

    PHYS.ORG  https://phys.org/news/2021-10-unique-underpinnings-revealed-stomach-acid.html  2021.10

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    Author:Other 

  18. 胃酸を分泌するタンパク質を改造!? ~輸送するイオンの数を人工的に変えることに成功~ Internet

    日本の研究.com  2021.9

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    Author:Other 

  19. 細胞死をつかさどる脂質輸送体の作動メカニズム Newspaper, magazine

    科学新聞  2020.10

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    Author:Other 

  20. Eat Me!! 細胞死を司る脂質輸送体の作動メカニズムが電子顕微鏡による構造解析で明らかに! Internet

    日本の研究.com  2020.10

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    Author:Other 

  21. 一度に幾つの荷物を運べる?? ~胃酸分泌を担う胃プロトンポンプが輸送するイオンの個数を構造解析によって決定~ Internet

    日本の研究.com  2019.9

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    Author:Other 

  22. 胃プロトンポンプの構造解明 TV or radio program

    NHK  2018.4

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    Author:Other 

  23. 世界初!胃酸分泌を担う胃プロトンポンプの構造を解明―胃酸抑制剤結合構造と強酸に対してプロトンを吐き出す仕組み― Internet

    日本の研究.com  https://research-er.jp/articles/view/69534  2018.4

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    Author:Other 

  24. 胃酸分泌 タンパク質解明 Newspaper, magazine

    中日新聞  2018.4

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    Author:Other 

  25. 強い酸性の胃液 仕組み解明 Newspaper, magazine

    朝日新聞  朝日新聞  2018.4

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