Updated on 2021/05/19

写真a

 
OSHIMA Atsunori
 
Organization
Cellular and Structural Physiology Institute Division Professor
Graduate School of Pharmaceutical Sciences
Title
Professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(理学) ( 2003.3   京都大学 ) 

 

Papers 24

  1. クライオ電子顕微鏡が加速するギャップ結合の構造研究 Invited

    大嶋篤典

    生体の科学   Vol. 71 ( 4 ) page: 315-320   2020.8

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    Authorship:Lead author   Language:Japanese  

  2. Presence of intrinsically disordered proteins can inhibit the nucleation phase of amyloid fibril formation of A beta(1-42) in amino acid sequence independent manner

    Ikeda Koki, Suzuki Shota, Shigemitsu Yoshiki, Tenno Takeshi, Goda Natsuko, Oshima Atsunori, Hiroaki Hidekazu

    SCIENTIFIC REPORTS   Vol. 10 ( 1 )   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-69129-1

    Web of Science

  3. Structural insights into gap junction channels boosted by cryo-EM Invited Reviewed

    Atsunori Oshima

      Vol. 63   page: 42-48   2020.4

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    Authorship:Lead author   Language:English  

    DOI: 10.1016/j.sbi.2020.03.008

  4. Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids Reviewed

    Batuujin Burendei, Ruriko Shinozaki, Masakatsu Watanabe, Tohru Terada, Kazutoshi Tani, Yoshinori Fujiyoshi, and Atsunori Oshima

    Science Advances   Vol. 6 ( 7 ) page: eaax3157   2020.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.aax3157

  5. Potential of cryo-EM for high-resolution structural analysis of gap junction channels Invited Reviewed

    Atsunori Oshima

    CURRENT OPINION IN STRUCTURAL BIOLOGY   Vol. 54   page: 78-85   2019.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.sbi.2019.01.005

    Web of Science

  6. イネキシンギャップ結合チャネルの原子分解能単粒子解析 Invited

    大嶋篤典

    顕微鏡   Vol. 52   page: 153-159   2017.12

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    Authorship:Lead author   Language:Japanese  

  7. Structure of an innexin gap junction channel and cryo-EM sample preparation Invited Reviewed

    Atsunori Oshima

    MICROSCOPY   Vol. 66 ( 6 ) page: 371-379   2017.12

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    Authorship:Lead author   Language:English  

    DOI: 10.1093/jmicro/dfx035

    Web of Science

  8. Atomic structure of the innexin-6 gap junction channel determined by cryo-EM Reviewed

    Oshima, A., Tani, K. and Fujiyoshi, Y.

    Nature communications   Vol. 7   page: 13681   2016.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms13681

  9. Hexadecameric structure of an invertebrate gap junction channel Reviewed

    Oshima, A., Matsuzawa, T., Murata, K., Tani, K. and Fujiyoshi, Y.

    J. Mol. Biol.   Vol. 428   page: 1227-1236   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jmb.2016.02.011.

  10. ギャップ結合チャネルの構造と多様性 Invited Reviewed

    大嶋篤典

    膜(MEMBRANE)   Vol. 41   page: 50-56   2016.3

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  11. GraDeR: membrane protein complex preparation for single particle cryo-EM. Reviewed

    Hauer, F., Gerle,C., Fischer, N., Oshima, A., Shinzawa-Itoh, K., Shimada, S., Yokoyama, K., Fujiyoshi, Y., Stark, H.

    Structure   Vol. 23   page: 1769-1775   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  12. Structure and closure of connexin gap junction channels Invited Reviewed

    A. Oshima

    FEBS Letters   Vol. 588   page: 1230-1237   2014.2

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    Authorship:Lead author   Language:English  

  13. Oligomeric Structure and Functional Characterization of Caenorhabditis elegans Innexin-6 Gap Junction Protein Reviewed

    A. Oshima, T. Matsuzawa, K. Nishikawa, and Y. Fujiyoshi

    Journal of Biological Chemistry   Vol. 288   page: 10513-10521   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  14. Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels Reviewed

    A. Oshima, K. Tani, M. M. Toloue, Y. Hiroaki, A. Smock, S. Inukai, A. Cone, B. J. Nicholson ,G. E. Sosinsky, and Y. Fujiyoshi

    Journal of Molecular Biology     2011

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jmb.2010.10.032

  15. Two-dimensional kinetics of inter-connexin interactions from single molecule force spectroscopy Reviewed

    F. Rico, A. Oshima, P. Hinterdorfer, Y. Fujiyoshi, and S. Scheuring

    Journal of Molecular Biology     2011

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jmb.2011.07.013

  16. Analysis of four connexin26 mutant gap junctions and hemichannels reveals variations in hexamer stability Reviewed

    C. Ambrosi, D. Boassa, J. Pranskevich, A. Smock, A. Oshima, J. Xu, B. J. Nicholson ,G. E. Sosinsky

    Biophysical Journal     2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bpj.2010.01.019

  17. 電子線結晶構造解析から導かれたギャップ結合チャネルのプラグゲーティング機構

    大嶋篤典

    顕微鏡   Vol. 44 ( 2 ) page: 87-92   2009

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  18. The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes Reviewed

    O. Gaßmann, M. Kreir, C. Ambrosi, J. Pranskevich, A. Oshima, C. Röling, G. Sosinsky, N. Fertig, and C. Steinem

    Journal of Structural Biology     2009

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jsb.2009.02.004

  19. Structure of the connexin 26 gap junction channel at 3.5Å resolution Reviewed

    S. Maeda, S. Nakagawa, M. Suga, E. Yamashita, A. Oshima, Y. Fujiyoshi and T. Tsukihara

    Nature     2009

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature07869

  20. Projection structure of a N-terminal deletion mutant of connexin 26 channel with decreased central pore density Reviewed

    A. Oshima, K. Tani, Y. Hiroaki, Y. Fujiyoshi, and G. E. Sosinsky

    Cell Communication and Adhesion     2008

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/15419060802013588

  21. Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule Reviewed

    A. Oshima, K. Tani, Y. Hiroaki, Y. Fujiyoshi, and G. E. Sosinsky

    Proceedings of the National Academy of Sciences of the United States of America     2007

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.0703704104

  22. Mutation of a conserved threonine in the third transmembrane helix of and connexins creates a dominant-negative closed gap junction channel Reviewed

    D. Beahm, A. Oshima, G. M. Gaietta, G. M. Hand, A. E. Smock, S. N. Zucker, M. M. Toloue, A. Chandrasekhar, B. J. Nicholson, and G. E. Sosinsky

    Journal of Biological Chemistry     2006

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M506533200

  23. Roles of Met-34, Cys-64, and Arg-75 in the assembly of human connexin 26. IMPLICATION FOR KEY AMINO ACID RESIDUES FOR CHANNEL FORMATION AND FUNCTION Reviewed

    A. Oshima, T. Doi, K. Mitsuoka, S. Maeda, and Y. Fujiyoshi

    Journal of Biological Chemistry     2003

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M207713200

  24. The 11Å resolution projection map of Na+/K+-ATPase calculated by application of single particle analysis to two-dimensional crystal images Reviewed

    Y. Tahara, A. Oshima, T. Hirai, K. Mitsuoka, Y. Fujiyoshi, and Y. Hayashi

    Journal of Electron Microscopy   Vol. 49 ( 4 ) page: 583-587   2000

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    Language:English   Publishing type:Research paper (scientific journal)  

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MISC 1

  1. クライオ電子顕微鏡で見るギャップ結合チャネルの構造 Invited

    大嶋篤典

    細胞   Vol. 51   page: 8-11   2019

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    Authorship:Lead author   Language:Japanese  

Research Project for Joint Research, Competitive Funding, etc. 1

  1. クライオ電子顕微鏡のフィードバックに基づく膜タンパク質複合体の生産と技術支援

    2017.4 - 2022.3

    創薬等ライフサイエンス研究支援基盤事業 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. Studies in structural physiology of channels

    Grant number:15H05775  2015.5 - 2020.3

    FUJIYOSHI Yoshinori

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    Authorship:Coinvestigator(s) 

    Structural information of membrane proteins including channels is crucial toward gaining a better understanding of biologic functions. The information that can be gained from a protein structure strongly depends on its resolution - the higher the resolution, the more insight gained into the structure-function relationship of biologic macromolecules. We analyzed structures of proton pump, water channel AQP4, whose inhibitor could be a drug for brain edema, Na+ channel, gap junction channels and tight junction channels at high resolutions. While we could not get significant results of AChR, we analyzed structures of endothelin receptor and its complexes with the agonist and antagonists. In this project, we could get important knowledge in the research field named as structural physiology and partly elucidate how the channels work and regulate functions of the human body. We also contributed advancement of cryo-electron microscopy by developing cryo-electron microscopes.