論文 - 兒玉 哲也
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Recent developments of artificial functional oligo nucleic acids 査読有り
Moai Yoshihiro, Kodama Tetsuya
TETRAHEDRON LETTERS 61 巻 ( 14 ) 2020年4月
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Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base
Moai Yoshihiro, Hiroaki Hidekazu, Obika Saoshi, Kodama Tetsuya
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 頁： 1-10 2019年10月
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Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules
Takenaga Naoko, Hayashi Takumi, Ueda Shohei, Satake Hiroyuki, Yamada Yoichi, Kodama Tetsuya, Dohi Toshifumi
MOLECULES 24 巻 ( 17 ) 2019年9月
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High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway 査読有り
Seiji Ishii, Kenji Fukui, Satoshi Yokoshima, Kazuo Kumagai, Youko Beniyama, Tetsuya Kodama, Tohru Fukuyama, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima, Takato Yano
Scientific Reports 頁： 4029 2017年6月
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Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle 査読有り
Takashi Hara, Tetsuya Kodama, Yumi Takegaki, Kunihiko Morihiro, Kosuke Ramon Ito, and Satoshi Obika
The Journal of Organic Chemistry 82 巻 ( 1 ) 頁： 25-36 2016年12月
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Systematic Evaluation of Biophysical and Functional Characteristics of Selenomethylene-Locked Nucleic Acid-Mediated Inhibition of miR-21 査読有り
Smita Nahar, Amrita Singh, Kunihiko Morihiro, Yoshihiro Moai, Tetsuya Kodama, Satoshi Obika, Souvik Maiti
Biochemistry 55 巻 ( 50 ) 頁： 7023-7032 2016年11月
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Wavelength-selective light-triggered strand exchange reaction 査読有り
Kunihiko Morihiro, Tetsuya Kodama, Shohei Mori, Shin-ichi Tsunoda, Satoshi Obika
Organic & Biomolecular Chemistry 14 巻 ( 5 ) 頁： 1555-1558 2015年12月
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Synthesis and hybridization property of a boat-shaped pyranosyl nucleic acid containing an exocyclic methylene group in the sugar moiety. 査読有り
Kazuto Mori, Tetsuya Kodama, Satoshi Obika.
Bioorganic & Medicinal Chemistry 23 巻 ( 1 ) 頁： 33-37 2014年12月
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Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18F-incorporated oligodeoxynucleotides. 査読有り
Hidefumi Mukai, Daiki Ozaki, Yilong Cui, Takeshi Kuboyama, Hiroko Yamato-Nagata, Kayo Onoe, Maiko Takahashi, Yasuhiro Wada, Takeshi Imanishi, Tetsuya Kodama, Satoshi Obika, Masaaki Suzuki, Hisashi Doi, Yasuyoshi Watanabe.
Journal of Controlled Release 180 巻 頁： 92-99 2014年2月
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Photoinduced changes in hydrogen bonding patterns of 8-thiopurine nucleobase analogues in a DNA strand. 査読有り
Kunihiko Morihiro, Tetsuya Kodama, Shohei Mori, Satoshi Obika.
Organic & Biomolecular Chemistry 12 巻 ( 15 ) 頁： 2468-2473 2014年2月
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Light-triggered strand exchange reaction using the change in the hydrogen bonding pattern of a nucleobase analogue. 査読有り
Kunihiko Morihiro, Tetsuya Kodama, Reiko Waki, Satoshi Obika.
Chemical Science 5 巻 ( 2 ) 頁： 744-750 2013年10月
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Selenomethylene Locked Nucleic Acid Enables Reversible Hybridization in Response to Redox Changes.
Kunihiko Morihiro, Tetsuya Kodama, Kentefu, Yoshihiro Moai, Rakesh N. Veedu, and Satoshi Obika.
Angew. Chem. Int. Ed. 52 巻 ( 19 ) 頁： 5074-5078 2013年4月
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Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency. 査読有り
Aiko Yahara, Ajaya Ram Shrestha, Tsuyoshi Yamamoto, Yoshiyuki Hari, Takashi Osawa, Masaki Yamaguchi, Masaru Nishida, Tetsuya Kodama and Satoshi Obika
ChemBioChem 13 巻 ( 17 ) 頁： 2513-2516 2012年11月
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Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases. 査読有り
Megan Wheeler, Antoine Chardon, Astrid Goubet, Kunihiko Morihiro, Sze Yee Tsan, Stacey L. Edwards, Tetsuya Kodama, Satoshi Obika and Rakesh N. Veedu.
Chemical Communications 48 巻 ( 89 ) 頁： 11020-11022 2012年10月
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Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides. 査読有り
S.M. Abdur Rahman, Takeshi Baba, Tetsuya Kodama, Md. Ariful Islam, Satoshi Obika.
Bioorganic & Medicinal Chemistry, 20 巻 ( 13 ) 頁： 4098-4103 2012年6月
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Synthesis and evaluation of novel caged DNA alkylating agents bearing 3,4-epoxypiperidine structure. 査読有り
Yuji Kawada, Tetsuya Kodama, Kazuyuki Miyashita, Takeshi Imanishi, Satoshi Obika
Organic & Biomolecular Chemistry 10 巻 ( 26 ) 頁： 5102-5108 2012年5月
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光るRNAアルファベット: チエノ[3,4-d]ピリミジン型核酸塩基
兒玉哲也
化学 67 巻 ( 4 ) 頁： 67-68 2012年3月
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Cleavage of oligonucleotides containing a P3'->N5' phosphoramidite linkage mediated by single-stranded oligonucleotide templates. 査読有り
Kosuke Ramon Ito, Tetsuya Kodama, Futaba Makimura, Noritsugu Hosoki, Tomohisa Osaki, Ayako Orita, Takeshi Imanishi, Satoshi Obika
Molecules 16 巻 ( 12 ) 頁： 10695-10708 2011年12月
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Design, synthesis and properties of boat-shaped glucopyranosyl nucleic acid. 査読有り
Kazuto Mori, Tetsuya Kodama, Satoshi Obika
Organic Letters 13 巻 ( 22 ) 頁： 6050–6053 2011年10月
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Repair of the major lesion resulting from C5'-oxidation of DNA. 査読有り
Kwan-Young Jung, Tetsuya Kodama, Marc M. Greenberg
Biochemistry 50 巻 ( 28 ) 頁： 6273–6279 2011年6月
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Benzylidene acetal-type bridged nucleic acids: changes in properties upon cleavage of the bridge triggered by external stimuli. 査読有り
Kunihiko Morihiro, Tetsuya Kodama, Satoshi Obika
Chemistry - A European Journal 17 巻 ( 28 ) 頁： 7918–7926 2011年6月
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Bridged nucleic acid conjugates at 6'-thiol: synthesis, hybridization properties and nuclease resistances. 査読有り
Kazuto Mori, Tetsuya Kodama, Takeshi Baba, Satoshi Obika.
Organic &. Biomolecular Chemistry 9 巻 ( 14 ) 頁： 5272-5279 2011年4月
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外部刺激応答型人工核酸スイッチの設計と合成. 査読有り
兒玉哲也
131 巻 ( 1 ) 頁： 101-111 2011年1月
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架橋型人工核酸BNAの開発（４）：外部刺激応答型人工核酸スイッチへの展開 査読有り
兒玉哲也, 今西武, 小比賀聡
14 巻 ( 2 ) 頁： 35-44 2010年12月
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A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes 査読有り
Takeshi Baba, Tetsuya Kodama, Kazuto Mori, Takeshi Imanishi, and Satoshi Obika.
Chemical Communications 46 巻 頁： 8058-8060. 2010年9月
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Double-stranded DNA-templated cleavage of oligonucleotides containing a P3'->N5' linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity. 査読有り
Kosuke Ramon Ito, Tetsuya Kodama, Masaharu Tomizu, Yoshinori Negoro, Ayako Orita, Tomohisa Osaki, Noritsugu Hosoki, Takaya Tanaka, Takeshi Imanishi, and Satoshi Obika.
Nucleic Acids Research 38 巻 ( 20 ) 頁： 7332-7342. 2010年7月
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Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure. 査読有り
Masaru Nishida, Takeshi Baba, Tetsuya Kodama, Aiko Yahara, Takeshi Imanishi, and Satoshi Obika.
Chemical Communications 46 巻 ( 29 ) 頁： 5283-5285 2010年6月
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Synthesis and evaluation of novel 3,4-epoxypiperidines as efficient DNA alkylating agents. 査読有り
Yuji Kawada, Tetsuya Kodama, Kazuyuki Miyashita, Takeshi Imanishi, and Satoshi Obika.
Heterocycles 80 巻 ( 2 ) 頁： 1249-1265 2009年10月
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Development of light-responsive BNA toward the spatiotemporal control of gene expression.
Kunihiko Morihiro, Tetsuya Kodama, Masaru Nishida, Takeshi Imanishi, and Satoshi Obika.
Nucleic Acids Symp Ser 53 巻 頁： 187-188 2009年9月
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Synthesis and properties of a novel 2',4'-BNA bearing a urea bridged structure.
Aiko Yahara, Masaru Nishida, Takeshi Baba, Tetsuya Kodama, Takeshi Imanishi, and Satoshi Obika.
Nucleic Acids Symp Ser 53 巻 頁： 11-12 2009年9月
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Synthesis and properties of a novel artificial nucleoside that acts as a redox switch.
Takeshi Baba, Tetsuya Kodama, Takeshi Imanishi, and Satoshi Obika.
Nucleic Acids Symp Ser 53 巻 頁： 107-108 2009年9月
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Synthesis of light-responsive bridged nucleic acid and changes in affinity with complementary ssRNA. 査読有り
Kunihiko Morihiro, Tetsuya Kodama, Masaru Nishida, Takeshi Imanishi and Satoshi Obika.
ChemBioChem 10 巻 ( 11 ) 頁： 1784-1788 2009年7月
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A bridged nucleic acid, 2',4'-BNACOC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2',4'-BNACOC monomers, and RNA-selective nucleic acid recognition. 査読有り
Yasunori Mitsuoka, Tetsuya Kodama, Ryo Ohnishi, Yoshiyuki Hari, Takeshi Imanishi and Satoshi Obika.
Nucleic Acids Research 37 巻 ( 4 ) 頁： 1225-1238 2009年1月
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Design, synthesis, and evaluation of a novel bridged nucleic acid, 2',5'-BNAON, with S-type sugar conformation fixed by N-O linkage. 査読有り
Tetsuya Kodama, Chieko Matsuo, Hidetsugu Ori, Tetsuya Miyoshi, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi.
Tetrahedron 65 巻 ( 10 ) 頁： 2116-2123 2008年12月
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Synthesis of a novel trans-3',4'-BNA monomer bearing a 4,8-dioxa-5-azabicyclo[5.3.0]decane skeleton. 査読有り
Tetsuya Kodama, Kensaku Sugaya, Takeshi Baba, Takeshi Imanishi and Satoshi Obika.
Heterocycles 79 巻 ( 1 ) 頁： 873-882 2008年11月
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Synthesis and properties of 2'-deoxy-trans-3',4'-BNA with S-type sugar puckering. 査読有り
Tetsuya Kodama, Kensaku Sugaya, Yasuki Harada, Yasunori Mitsuoka, Takeshi Imanishi and Satoshi Obika.
Heterocycles 77 巻 頁： 1209-1217 2008年10月
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Design and Chemical Synthesis of a 2',4'-BNA Probe for 7,8-Dihydro-8-oxoguanine-containing Double Stranded DNA.
Tetsuya Miyoshi, Tetsuya Kodama, Satoshi Obika and Takeshi Imanishi.
Nucleic Acids Symp Ser 52 巻 頁： 305-306 2008年9月
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二リン酸ジエステル結合で連なるDNA. 査読有り
兒玉哲也
ファルマシア 44 巻 ( 1 ) 頁： 71-72 2008年4月
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Synthesis and evaluation of a novel 2',5'-bridged nucleic acid with sugar conformation fixed to S-type by N-O linkage.
Tetsuya Kodama, Chieko Matsuo, Hidetsugu Ori, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi.
Nucleic Acids Symp Ser 51 巻 頁： 159-160 2007年11月
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Synthesis and properties of a 2'-deoxy analogue of trans-3',4'-BNA with an S-type sugar conformation.
Kensaku Sugaya, Y. Harada, Yasunori Mitsuoka, Tomohisa Osaki, Satoshi Obika, Tetsuya Kodama, Takeshi Imanishi.
Nucleic Acids Symp Ser 51 巻 頁： 155-156 2007年11月
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Synthesis and chemical properties of a novel 2',4'-bridged nucleic acid analogue with a seven-membered cyclic carbamate structure.
Masaru Nishida, Tetsuya Kodama, Satoshi Obika, Takeshi Imanishi.
Nucleic Acids Symp Ser 51 巻 頁： 157-158 2007年11月
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C5'酸化損傷DNAの有機合成とその科学的性質.
兒玉哲也
大阪大学低温センターだより 138 巻 ( 1 ) 頁： 18-21 2007年7月
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Selective detection and quantification of oxidized abasic lesions in DNA. 査読有り
Shanta Dhar, Tetsuya Kodama, and Marc M. Greenberg.
Journal of the American Chemical Society 129 巻 頁： 8702-8703 2007年6月
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Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines.
Satoshi Shuto, Yutaka Tamura, Yuji Yamamoto, Tetsuya Kodama, Shuichi Hoshika, Satoshi Ichikawa, Yoshihito Ueno, Eiko Ohtsuka, Yasuo Komatsu, and Akira Matsuda.
Nucleic Acids Symp Ser 48 巻 頁： 67-68 2006年12月
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The first synthesis of 1'-fluoronucleosides.
Tetsuya Kodama, Akira Matsuda and Satoshi Shuto.
Nucleic Acids Symp Ser 50 巻 頁： 3-4 2006年12月
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Synthesis of 1'-fluorouracil nucleosides as potential antimetabolites. 査読有り
Tetsuya Kodama, Akira Matsuda and Satoshi Shuto.
Tetrahedron 62 巻 ( 42 ) 頁： 10011-10017 2006年10月
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Synthesis of pyrimidine 1'-fluoronucleosides. 査読有り
Tetsuya Kodama, Satoshi Shuto and Akira Matsuda.
Tetrahedron Letters 47 巻 ( 23 ) 頁： 4439-4432 2006年6月
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Preparation and analysis of oligonucleotides containing lesions resulting from C5'-oxidation. 査読有り
Tetsuya Kodama and Marc M. Greenberg.
The Jounal of Organic Chemistry 70 巻 ( 24 ) 頁： 9916-9924 2005年11月
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Mechanistic studies on DNA damage by minor groove binding copper-phenanthroline conjugates. 査読有り
Brian C. Bales, Tetsuya Kodama, Yvonne N. Weledji, Marguerite Pitie, Bernard Meunier and Marc M. Greenberg.
Nucleic Aicds Research 33 巻 ( 16 ) 頁： 5371-5379 2005年9月
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Oligodeoxynucleotides having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines form stable hairpins. 査読有り
Yuji Yamamoto, Satoshi Shuto, Yutaka Tamura, Tetsuya Kodama, Shuichi Hoshika, Satoshi Ichikawa, Yoshihito Ueno, Eiko Ohtsuka, Yasuo Komatsu and Akira Matsuda.
Biochemistry 43 巻 ( 27 ) 頁： 8690-8699 2004年7月
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Synthesis and radiacal reaction of 1'-phenylselenonucleosides.
Tetsuya Kodama, Satoshi Shuto, Makoto Nomura and Akira Matsuda.
Nucleic Acids Symp Ser 44 巻 頁： 109-110 2003年8月
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A highly stereoselective samarium diiodide-promoted aldol reaction with l'-phenylseleno-2'-keto nucleosides. Synthesis of 1'alpha-branched uridine derivatives. 査読有り
Tetsuya Kodama, Satoshi Shuto, Satoshi Ichikawa and Akira Matsuda.
The Jounal of Organic Chemistry 67 巻 ( 22 ) 頁： 7706-7715 2002年11月
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An efficient method for the preparation of 1'alpha-branched-chain sugar pyrimidine ribonucleosides from uridine: The first conversion of a natural nucleoside into 1'-substituted ribonucleosides. 査読有り
Tetsuya Kodama, Satoshi Shuto and Akira Matsuda.
Chemistry-a European Journal 7 巻 ( 11 ) 頁： 2332-2340 2001年6月
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Synthesis of a 1'-alpha-phenylselenouridine derivative as a synthetic precursor for various 1'-modified nucleosides, via enolization at the 1'-position of 3',5'-O-TIPDS-2'-ketouridine. 査読有り
Tetsuya Kodama, Satoshi Shuto, Makoto Nomura and Akira Matsuda.
Tetrahedron Letters 41 巻 ( 19 ) 頁： 3643-3646 2000年5月