Updated on 2022/04/04

写真a

 
Masatoshi Shibuya
 
Organization
Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Organic Chemistry Associate professor
Graduate School
Graduate School of Engineering
Graduate School of Pharmaceutical Sciences
Undergraduate School
School of Engineering Chemistry and Biotechnology
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 博士(薬学) ( 2009.1   東北大学 ) 

Research Interests 1

  1. Organic Synthesis

Research History 3

  1. associate professor

    2012.4

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    Country:Japan

  2. assistant professor

    2009.3 - 2012.3

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    Country:Japan

  3. 助手

    2002.10 - 2009.2

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    Country:Japan

Education 2

  1. Tohoku University   Graduate School, Division of Pharmaceutical Sciences

    2002.4 - 2002.9

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    Country: Japan

  2. Tohoku University   Faculty of Pharmaceutical Science

    1998.4 - 2002.3

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    Country: Japan

Professional Memberships 5

  1. 日本プロセス化学会

  2. 有機合成化学協会

  3. 日本薬学会

  4. 日本化学会

  5. American Chemical Society

 

Papers 71

  1. Boron-Catalyzed Double Hydrofunctionalization Reactions of Unactivated Alkynes

    Shibuya Masatoshi, Okamoto Masaki, Fujita Shoji, Abe Masanori, Yamamoto Yoshihiko

    ACS CATALYSIS   Vol. 8 ( 5 ) page: 4189-4193   2018.5

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acscatal.8b00955

    Web of Science

  2. Bronsted Acid/Silane Catalytic System for Intramolecular Hydroalkoxylation and Hydroamination of Unactivated Alkynes Reviewed

    Masatoshi Shibuya, Shoji Fujita, Masanori Abe, Yoshihiko Yamamoto

    ACS Catalysis   Vol. 7 ( 4 ) page: 2848-2852   2017.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  3. Chemoselective Catalytic Oxidation of 1,2-Diols to α-Hydroxy Acids Controllewd by TEMPO-ClO2 Charge-Transfer Complex Reviewed

    Keisuke Furukawa, Masatoshi Shibuya, Yoshihiko Yamamoto

    Organic Letters   Vol. 17 ( 9 ) page: 2282-2285   2015.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.5b01003

  4. Intramolacular Hydroalkoxylation of Unactivated Alkenes Using Silane-Iodine Catalytic System Reviewed

    Shoji Fujita, Masanori Abe, Masatoshi Shibuya, Yoshihiko Yamamoto

    Organic Letters   Vol. 17 ( 15 ) page: 3822-3825   2015.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.5b01797

  5. Highly efficient, organocatalytic aerobic alcohol oxidation Reviewed

    Masatoshi Shibuya, Yuji Osada, Yusuke Sasano, Masaki Tomizawa, Yoshiharu Iwabuchi

    Journal of the American Chemical Society   Vol. 133 ( 17 ) page: 6497-6500   2011.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  6. One-pot, two-step synthesis of unnatural alpha-amino acids involving the exhaustive aerobic oxidation of 1,2-diols

    Inada Haruki, Furukawa Keisuke, Shibuya Masatoshi, Yamamoto Yoshihiko

    CHEMICAL COMMUNICATIONS   Vol. 55 ( 100 ) page: 15105 - 15108   2019.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9cc07889d

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    PubMed

  7. Collection of Data Variation Using a High-Throughput Image-Based Assay Platform Facilitates Data-Driven Understanding of TRPA1 Agonist Diversity

    Terada Yuko, Tanaka Kenjiro, Matsuyama Minami, Fujitani Masaya, Shibuya Masatoshi, Yamamoto Yoshihiko, Kato Ryuji, Ito Keisuke

    APPLIED SCIENCES-BASEL   Vol. 12 ( 3 )   2022.2

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    Language:Japanese  

    DOI: 10.3390/app12031622

    Web of Science

  8. N-Hydroxyphthalimide-catalyzed chemoselective intermolecular benzylic C-H amination of unprotected arylalkanols

    Shibuya Masatoshi, Orihashi Takayuki, Li Yamei, Yamamoto Yoshihiko

    CHEMICAL COMMUNICATIONS   Vol. 57 ( 70 ) page: 8742 - 8745   2021.9

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  9. 1,2-Carbopentafluorophenylation of Alkynes: The Metallomimetic Pull-Push Reactivity of Tris(pentafluorophenyl)borane

    Shibuya Masatoshi, Matsuda Miki, Yamamoto Yoshihiko

    CHEMISTRY-A EUROPEAN JOURNAL   Vol. 27 ( 34 ) page: 8822 - 8831   2021.6

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  10. Synthesis of Unprotected 2-Aryiglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine Reviewed

    Inada Haruki, Shibuya Masatoshi, Yamamoto Yoshihiko

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 85 ( 17 ) page: 11047 - 11059   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.0c01302

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  11. Nitroxyl radical-catalyzed chemoselective alcohol oxidation for the synthesis of polyfunctional molecules Invited Reviewed

    Shibuya Masatoshi

    TETRAHEDRON LETTERS   Vol. 61 ( 8 )   2020.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tetlet.2019.151515

    Web of Science

  12. Diastereoselective Methylation at the Congested beta-Position of a Butenolide Ring: Studies toward the Synthesis of seco-Prezizaane-Type Sesquiterpenes

    Kawamura Tomoyoshi, Moriya Hirokazu, Shibuya Masatoshi, Yamamoto Yoshihiko

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 84 ( 19 ) page: 12508 - 12519   2019.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.9b02017

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  13. Boron-Catalyzed Hydroamination/Hydroallylation and Hydroamination/Hydrocyanation of Unactivated Alkynes

    Shibuya Masatoshi, Kawano Shohei, Fujita Shoji, Yamamoto Yoshihiko

    ASIAN JOURNAL OF ORGANIC CHEMISTRY   Vol. 8 ( 7 ) page: 1075 - 1079   2019.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ajoc.201900165

    Web of Science

  14. SYNTHESIS OF gamma-DIFLUOROMETHYLATED TETRONATE DERIVATIVES FROM SQUARATES USING DIFLUOROMETHYLPHOSPHONATE

    Yamamoto Yoshihiko, Ishida Yuki, Kurohara Takashi, Shibuya Masatoshi, Yasui Takeshi

    HETEROCYCLES   Vol. 99 ( 1 ) page: 363 - 378   2019.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3987/COM-18-S(F)29

    Web of Science

  15. Direct Synthesis of Free alpha-Amino Acids by Telescoping Three-Step Process from 1,2-Diols

    Inada Haruki, Shibuya Masatoshi, Yamamoto Yoshihiko

    ORGANIC LETTERS   Vol. 21 ( 3 ) page: 709-713   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.8b03910

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  16. Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway

    Hibi Takahide, Ohtsuka Hokuto, Shimasaki Takafumi, Inui Shougo, Shibuya Masatoshi, Tatsukawa Hideki, Kanie Kei, Yamamoto Yoshihiko, Aiba Hirofumi

    GENES TO CELLS   Vol. 23 ( 8 ) page: 620-637   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12604

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  17. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

    Tsuburaya Naomi, Homma Kengo, Higuchi Tsunehiko, Balia Andrii, Yamakoshi Hiroyuki, Shibata Norio, Nakamura Seiichi, Nakagawa Hidehiko, Ikeda Shin-ichi, Umezawa Naoki, Kato Nobuki, Yokoshima Satoshi, Shibuya Masatoshi, Shimonishi Manabu, Kojima Hirotatsu, Okabe Takayoshi, Nagano Tetsuo, Naguro Isao, Imamura Keiko, Inoue Haruhisa, Fujisawa Takao, Ichijo Hidenori

    NATURE COMMUNICATIONS   Vol. 9 ( 1 ) page: 2668   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-018-05127-2

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  18. Synthesis of pyrroles via ruthenium-catalyzed nitrogen-transfer [2

    Matsui Kazuma, Shibuya Masatoshi, Yamamoto Yoshihiko

    COMMUNICATIONS CHEMISTRY   Vol. 1   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42004-018-0022-2

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  19. Synthesis of Alkoxycarbonyldifluoromethyl-Substituted Semisquarates and Their Transformations

    Kurohara Takashi, Jiyue Jiang, Shibuya Masatoshi, Yamamoto Yoshihiko

    SYNTHESIS-STUTTGART   Vol. 50 ( 8 ) page: 1687-1698   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0036-1591887

    Web of Science

  20. The vinylogous Catellani reaction: a combined computational and experimental study

    Yamamoto Y., Murayama T., Jiang J., Yasui T., Shibuya M.

    CHEMICAL SCIENCE   Vol. 9 ( 5 ) page: 1191-1199   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c7sc04265e

    Web of Science

  21. Intramolecular Hydroalkoxylation/Reduction and Hydroamination/Reduction of Unactivated Alkynes Using a Silane-Iodine Catalytic System

    Fujita Shoji, Shibuya Masatoshi, Yamamoto Yoshihiko

    SYNTHESIS-STUTTGART   Vol. 49 ( 18 ) page: 4199-4204   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0036-1588436

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  22. Combined Experimental and Computational Study on Ruthenium(II)Catalyzed Reactions of Diynes with Aldehydes and N,N-Dimethylformamide

    Yamamoto Yoshihiko, Okude Yuta, Mori Shota, Shibuya Masatoshi

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 82 ( 15 ) page: 7964-7973   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.7b01229

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  23. Selective Aerobic Oxidation of Primary Alcohols to Aldehydes

    Shibuya Masatoshi, Furukawa Keisuke, Yamamoto Yoshihiko

    SYNLETT   Vol. 28 ( 13 ) page: 1554-1557   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0036-1588155

    Web of Science

  24. Synthesis of 3-Aryl-2-(trifluoromethyl)indoles via Copper-Catalyzed Hydroarylation and Subsequent Cadogan Cyclization

    Yamamoto Yoshishiko, Ohkubo Erina, Shibuya Masatoshi

    ADVANCED SYNTHESIS & CATALYSIS   Vol. 359 ( 10 ) page: 1747-1751   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/adsc.201700122

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  25. Assembly of a Benzo-Fused Bridged Ketone Scaffold from 1,5,10-Enediynes through One-Pot Ruthenium-Catalyzed Cyclization/Iodine-Mediated Oxidative Ring Expansion

    Yamamoto Yoshihiko, Nishimura Kei-ichiro, Mori Shota, Shibuya Masatoshi

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 56 ( 20 ) page: 5494-5497   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201700493

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  26. Intramolecular Hydroalkoxylation/Reduction and Hydroamination/Reduction of Unactivated Alkynes Using a Silane-Iodine Catalytic System Invited Reviewed

    Shoji Fujita, Masatoshi Shibuya, Yoshihiko Yamamoto

    Synthesis   Vol. 49   page: 4199-4204   2017.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  27. Bronsted Acid/Silane Catalytic System for Intramolecular Hydroalkoxylation and Hydroamination of Unactivated Alkynes (vol 7, pg 2848, 2017)

    Shibuya Masatoshi, Fujita Shoji, Abe Masanori, Yamamoto Yoshihiko

    ACS CATALYSIS   Vol. 7 ( 5 ) page: 3356-3356   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acscatal.7b01100

    Web of Science

  28. Electrophilic Derivatization of Trifluoromethyl-Substituted Semisquarate Using Unsaturated Organosilanes and Subsequent Ring Transformations

    Kurohara Takashi, Shibuya Masatoshi, Yamamoto Yoshihiko

    ADVANCED SYNTHESIS & CATALYSIS   Vol. 359 ( 8 ) page: 1413-1419   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/adsc.201601297

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  29. Assembly of a Benzo-Fused Bridged Ketone Scaffold from 1,5,10-Endiynes through One-Pot Ruthenium-Catalyzed Cyclization/Iodine-Mediated Oxidative Ring Expansion

    Yoshihiko Yamamoto, Kei-ichiro Nishimura, Shota Mori, Masatoshi Shibuya

    Angewandte Chemie International Edition   Vol. 56 ( 20 ) page: 5494-5497   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  30. Selective Aerobic Oxidation of Primary Alcohols to Aldehydes Invited Reviewed

    Masatoshi Shibuya, Keisuke Furukawa, Yoshihiko Yamamoto

    Synlett   Vol. 28 ( 13 ) page: 1154-1157   2017.3

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  31. Electrophilic Derivatization of Trifluoromethyl-Substituted Semisquarate Using Unsaturated Organosilanes and Subsequent Ring Transformations Reviewed

    Takashi Kurohara, Masatoshi Shibuya, Yoshihiko Yamamoto

    Advanced Synthesis & Catalysis   Vol. 359 ( 8 ) page: 1413-1419   2017.2

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  32. The Anticancer Effects of Novel α-Bisabolol Derivatives Against Pancreatic Cancer

    Yoshihiko Murata, Toshio Kokuryo, Yukihiro Yokoyama, Junpei Yamaguchi, Tomohiro Niwa, Masatoshi Shibuya, Yoshihiko Yamamoto and Masato Nagino

    Anticancer Research   Vol. 37 ( 2 ) page: 589-598   2017.2

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  33. Ruthenium-Catalyzed Cycloisomerization of 1,6-Diynes with Styryl Terminals Leading to Indenylidene Cycloalkanes

    Yamamoto Yoshihiko, Nishimura Kei-ichiro, Shibuya Masatoshi

    ACS CATALYSIS   Vol. 7 ( 2 ) page: 1101-1107   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acscatal.6b03322

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  34. The Anticancer Effects of Novel alpha-Bisabolol Derivatives Against Pancreatic Cancer

    Murata Yoshihiko, Kokuryo Toshio, Yokoyama Yukihiro, Yamaguchi Junpei, Miwa Tomohiro, Shibuya Masatoshi, Yamamoto Yoshihiko, Nagino Masato

    ANTICANCER RESEARCH   Vol. 37 ( 2 ) page: 589-598   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.11352

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  35. Ruthenium-catalyzed Hydrocarbamoylative Cyclization of 1,6-Diynes with Formamides

    Mori Shota, Shibuya Masatoshi, Yamamoto Yoshihiko

    CHEMISTRY LETTERS   Vol. 46 ( 2 ) page: 207-210   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.160961

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  36. Ruthenium-Catalyzed Cycloisomerization of 1,6-Diynes with Styryl Terminals Leading to Indenylidene Cycloalkanes Reviewed

    Yoshihiko Yamamoto, Kei-ichiro Nishimura, Masatoshi Shibuya

    ACS Catalysis   Vol. 7 ( 2 ) page: 1101-1107   2016.12

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  37. Ruthenium-Catalyzed Hydrocarbamoylative Cyclization of 1,6-Diynes with Formamides Reviewed

    Shota Mori, Masatoshi Shibuya, and Yoshihiko Yamamoto

    Chemistry Letters   Vol. 46   page: 207-210   2016.11

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  38. 有機ニトロキシラジカルの酸化還元特性を利用した効率的酸化システムの開発ー第一級アルコールからカルボン酸への酸化反応ー Invited Reviewed

    澁谷正俊

    有機合成化学協会誌   Vol. 74 ( 10 ) page: 965-974   2016.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  39. Chemoselective Conversion from α-Hydroxy Acids to α-Keto Acids Enabled by Nitroxyl-Radical-Catalyzed Aerobic Oxidation Reviewed

    Keisuke Furukawa, Haruki Inada, Masatoshi Shibuya*, and Yoshihiko Yamamoto

    Organic Letters   Vol. 18 ( 17 ) page: 4230-4233   2016.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.6b01964

  40. Reagents for diverse iodosilane-mediated transformations Reviewed

    Masatoshi Shibuya, Masanori Abe, Shoji Fujita, and Yoshihiko Yamamoto

    Organic & Biomolecular Chemistry   Vol. 14   page: 5322-5328   2016.5

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  41. Synthesis of 4-Aryl-2-Quinolones via Cooper-Catalyzed Hydroarylation of (o-Aminophenyl)propiolates with Arylboronates Reviewed

    Tsukasa Murayama, Masatoshi Shibuya, and Yoshihiko Yamamoto

    Advanced Synthesis & Catalysis   Vol. 358   page: 166-171   2016.1

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  42. Lactone-fused Cyclohexadiene as Versatile Platform for Diversified Synthesis of 5,6,5-Tricyclic Scaffolds Reviewed

    Masatoshi Shibuya, Tomonori Sudo, Tomoyoshi Kawamura, Yoshihiko Yamamoto

    Organic & Biomolecular Chemistry   Vol. 13   page: 5862-5866   2015.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C5OB00729A

  43. A Combined Experimental and Computational Study on the Cycloisomerization of 2-Ethynylbiaryls Catalyzed by Dicationic Arene Ruthenium Complexes Reviewed

    Yoshihiko Yamamoto, Kazuma Matsui, Masatoshi Shibuya

    Chemistry - A European Journal   Vol. 21 ( 19 ) page: 7245-7255   2015.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201500248

  44. A Combined Transition-Metal-Catalyzed and Photopromoted Process: Synthesis of 2,3-Fused 4-Phenylnaphthalen-1-yl Carboxylates from 1,7-Diaryl-1,6-diynes Reviewed

    Yoshihiko Yamamoto, Shota Mori, Masatoshi Shibuya

    Chemistry - A European Journal   Vol. 21   page: 9093-9100   2015.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201500978

  45. Synthesis of 3,4-Fused 2-Qunolones from an (ortho-Aminophenyl)proliolate via Sequential Cycloaddition/Lactam Formation Reviewed

    Tsukasa Murayama, Masatoshi Shibuya, Yoshihiko Yamamoto

    Advanced Synthesis & Catalysis   Vol. 357 ( 4 ) page: 690-694   2015.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/adsc.201401069

  46. Development of an Azanoradamantane-Type Nitroxyl Radical Catalyst for Class-Selective Oxidation of Alcohols Reviewed

    Ryusuke Doi, Masatoshi Shibuya, Tsukasa Murayama, Yoshihiko Yamamoto, and Yoshiharu Iwabuchi

    The Journal of Organic Chemistry   Vol. 80 ( 1 ) page: 401-413   2015.1

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    DOI: 10.1021/jo502426p

  47. Mechanistic Insight into Aerobic Alcohol Oxidation Using NOx-Nitroxide Catalysis Based on Catalyst Structure-Activity Relationships

    Masatoshi Shibuya, Shota Nagasawa, Yuji Osada, Yoshiharu Iwabuchi

    The Journal of Organic Chemistry   Vol. 79 ( 21 ) page: 10256-10268   2014.10

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  48. Enantioselective Intramolecular Aza-Spiroannulation onto Benzofurans Using Chiral Rhodium Catalysis Reviewed

    Takuro Shibuta, Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, Tohru Taniguchi, Kenji Monde, Yoshiharu Iwabuchi

    Heterocycles   Vol. 89   page: 631-639   2014.3

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  49. Ruthenium-Catalyzed Transfer-Hydrogenative Cyclization of 1,6-Diynes with Hantzsch 1,4-Dihydropyridine as a H2 Surrogate Reviewed

    Yoshihiko Yamamoto, Shota Mori, Masatoshi Shibuya

    Chemistry - A European Journal   Vol. 19 ( 36 ) page: 12034-12041   2013.9

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  50. 有機ニトロキシルラジカルの反応性制御に基づく効率的アルコール空気酸化反応の開発 Reviewed

    澁谷正俊、岩渕好治

    有機合成化学協会誌   Vol. 71   page: 515-525   2013.5

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  51. オキソアンモニウム塩の設計に基づく有用酸化反応システムの開発研究 Reviewed

    澁谷正俊

    薬学雑誌   Vol. 132   page: 1131-1143   2012.10

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  52. Organocatalytic One-pot Oxidative Cleavage of Terminal Diols to Dehomologated Carboxylic Acids Reviewed

    Masatoshi Shibuya, Ryusuke Doi, Takuro Shibuta, Shun-ichiro Uesugi, Yoshiharu Iwabuchi

    Organic Letters   Vol. 14 ( 19 ) page: 5010-5013   2012.9

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  53. Nitroxyl Radical/PhI(OAc)2: One-Pot Oxidative Cleavage of Vicinal Diols to (Di)Carboxylic Acids Reviewed

    Masatoshi Shibuya, Takuro Shibuta, Hayato Fukuda, Yoshiharu Iwabuchi

    Organic Letters   Vol. 14 ( 19 ) page: 5010-5013   2012.9

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  54. Catalytic Oxidation of Silyl Enol Ethers to 1,2-Diketones Employing Nitroxyl Radicals Reviewed

    Masaki Hayashi, Masatoshi Shibuya, Yoshiharu Iwabuchi

    Synlett   Vol. 23 ( 7 ) page: 1025-1031   2012.4

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  55. Oxidation of Alcohols to Carbonyl Compounds with Diisopropyl Azodicarboxylate Catalyzed by Nitroxyl Radicals Reviewed

      Vol. 77   page: 3005-3009   2012.2

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  56. Oxidation of nitroxyl radicals: electrochemical and computational studies Reviewed

    Masatoshi Shibuya, Fabio Pichierri, Masaki Tomizawa, Shota Nagasawa, Iwao Suzuki, Yoshiharu Iwabuchi

    Tetrahedron Letters   Vol. 53 ( 16 ) page: 2070-2073   2012.2

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  57. Oxidative Conversion of Silyl Enol Ethers to alpha, beta-unsaturated Ketones Employing Oxoammnium Salts Reviewed

    Masaki Hayashi, Masatoshi Shibuya, Yoshiharu Iwabuchi

    Organic Letters   Vol. 14 ( 1 ) page: 154-157   2012.1

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  58. 9-Azanoradamantane N-Oxyl (Nor-AZADO): A Highly Active Organocatalyst for Alcohol Oxidation Reviewed

    Masaki Hayashi, Yusuke Sasano, Shota Nagasawa, Masatoshi Shibuya, Yoshiharu Iwabuchi

    Chemical and Pharmaceutical Bulletin   Vol. 59 ( 12 ) page: 1570-1573   2011.12

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  59. Practical Preparation Methods for Highly Active Azaadamantane-Nitroxyl-Radical Type Oxidation Catalysts Reviewed

    Masatoshi Shibuya, Yusuke Sasano, Masaki Tomizawa, Toshimasa Hamada, Masami Kozawa, Noriaki Nagahama, Yoshiharu Iwabuchi

    Synthesis   ( 21 ) page: 3418-3425   2011.7

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  60. Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apotosis via the mitochondrial pathway Reviewed

    Takumi Chinen, Yoko Nagumo, Tsubasa Watanabe, Takamichi Imaizumi, Masatoshi Shibuya, Takao Kataoka, Naoki Kanoh, Yoshiharu Iwabuchi, Takeo Usui

    Toxicology Letters   Vol. 199   page: 341-346   2010.9

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  61. An Enantio- and Diastereocontrolled Synthesis of (-)-Salinosporamide A Reviewed

    Yusuke Sato, Hayato Fukuda, Masaki Tomizawa, Tomohito Masaki, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi

    Heterocycles   Vol. 81 ( 10 ) page: 2239-2246   2010.8

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  62. Syntheses and Biological Evaluation of Irciniastatin A and C1-C2 Alkyne Analogue Reviewed

    Tsubasa Watanabe, Takamichi Imaizumi, Takumi Chinen, Yoko Nagumo, Masatoshi Shibuya, Takeo Usui, Naoki Kanoh, Yoshiharu Iwabuchi

    Organic Letters   Vol. 12 ( 5 ) page: 1040-1043   2010.2

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  63. Total Synthesis and Determination of the Absolute Configuration of (-)-Idesolide Reviewed

    Hiroyuki Yamakoshi, Masatoshi Shibuya, Masaki Tomizawa, Yuji Osada, Naoki Kanoh, Yoshiharu Iwabuchi

    Organic Letters   Vol. 12 ( 5 ) page: 980-983   2010.2

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  64. Highly Enantioseletive Intramolecular Aza-spiroannulation onto Indoles Using Chiral Rhodium Catalysis: Asymmetric Entry to the Spiro-beta-lactam Core of Chartellines Reviewed

    Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi

      ( 41 ) page: 6264-6266   2009.9

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  65. An Expedient Route to a Potent Gastrin/CCK-B Receptor Antagonist (+)-AG-041R Reviewed

    Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi

    The Journal of Organic Chemistry   Vol. 74 ( 19 ) page: 7522-7524   2009.8

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  66. Syntheses of naturally occurring cytotoxic[7.7]paracyclophanes, (-)-cylindrocyclophane A and its enantiomer, and implication for biologycal activity

    Hiroyuki Yamakoshi, Fumiya Ikarashi, Masataka Minami, Masatoshi Shibuya, Tsutomu Sugahara, Naoki Kanoh, Hisatsugu Ohori, Hiroyuki Shibata, Yoshiharu Iwabuchi

    Organic & Biomolecular Chemistry   Vol. 7 ( 18 ) page: 3772-3781   2009.7

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  67. An Expeditious Entry to 9-Azabicyclo[3.3.1]nonane N-Oxyl (ABNO): Highly Active Organocatalyst for Oxidation of Alcohols Reviewed

    Masatoshi Shibuya, Masaki Tomizawa, Yusuke Sasano, Yoshiharu Iwabuchi

    The Journal of the Organic Chemistry   Vol. 74 ( 12 ) page: 4619-4622   2009.5

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  68. Highly Enantioselective Organocatalytic Oxidative Kinetic Resolution of Secondary Alcohols Using Chirally Modified AZADOs Reviewed

    Organic Letters   Vol. 11 ( 8 ) page: 1829-1831   2009.3

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  69. Synthetic Studies on Daphnicyclidine A: Enantiocontrolled Construction of the BCD RIng System Reviewed

    Shuhei Ikeda, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi

    Organic Letters   Vol. 11 ( 8 ) page: 1833-1836   2009.3

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  70. Oxoammonium salt/NaClO2; An Expedient, Catalytic System for One-pot Oxidation of Primary Alcohols to Carboxylic Aicds with Broad Substrate Applicability Reviewed

    Masatoshi Shibuya, Takahisa Sato, Masaki Tomizawa, Yoshiharu Iwabuchi

    Chemical Communications   ( 13 ) page: 1739-1741   2009.2

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  71. Flexible Access to Monoterpenoid Indole Alkaloids Using a Cyclopentanoid Chiral Building Block Reviewed

    Masato Hayashi, Keniichi Motosawa, Atsushi Satoh, Masatoshi Shibuya, Kunio Ogasawara, Yoshiharu Iwabuchi

    Heterocycles   Vol. 77 ( 2 ) page: 855-863   2008.11

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Presentations 1

  1. トリス(ペンタフルオロフェニル)ボランによるフェニルアセチレンの求電子活性化を利用した三成分カップリング反応とその反応機構解析

    松田実季、澁谷正俊、山本芳彦

    日本薬学会 第141年会  2021.3.27  日本薬学会

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    Event date: 2020.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. 新規有機ニトロキシラジカル型酸化触媒の開発と神経栄養因子様活性天然物の合成

    2014.4 - 2016.3

    科学研究費補助金  新学術領域研究・公募研究

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    Authorship:Principal investigator 

    有機ニトロキシルラジカル触媒を用いる1,2-ジオールの酸化制御法の開発とセコプレジザン型セスキテルペノイドの全合成を目的として研究を行っている

  2. 触媒設計に基づく新しい選択性を発揮するアルコール酸化反応の開発

    2011.4 - 2015.3

    科学研究費補助金  若手研究(A)

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    Authorship:Principal investigator 

    私たちがこれまでに開発した高活性アザアダマンタン型有機ニトロキシルラジカル型酸化触媒に,適度な立体要求性あるいは,分子認識部位を付与することによってこれまでにない選択性でポリオールの特定のアルコールのみを選択的に酸化する手法を開発する.

  3. Development of polysubstituted heterocycles using boron catalysts

    Grant number:19K06973  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  4. Development of new strategy for electrophilic acitivation of C-C multiple bonds

    Grant number:16K08162  2016.4 - 2019.3

    Shibuya mastoid

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    Authorship:Principal investigator 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    Methodology enabling rapid access to various molecules having a diverse structure is important for pharmaceutical sciences. A synthetic method utilizing a C-C multiple bond is relatively limited comparing with that utilizing a carbonyl group. In this study, we have developed several reactions to construct heterocycles using novel catalytic electrophilic activation methods of C-C multiple bonds. Especially, we used main group metal compounds as the catalyst.

  5. 高活性有機酸化触媒アザアダマンタン型ニトロキシラジカルの不斉反応への展開

    2007.4 - 2009.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  6. 新規グルタミン酸配座固定化分子の合成に基づく受容体機能探索子の創製

    2006.4 - 2008.3

    科学研究費補助金  特定領域研究

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    Authorship:Principal investigator 

  7. 新規ニトロキシラジカル型アルコール酸化触媒の展開と環境調和プロセスへの展開

    2005.4 - 2007.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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Industrial property rights 2

  1. トリフルオロメチル置換セミスクアレートの製造方法,トリフルオロメチル置換セミスクアレートを起点とするトリフルオロメチル化合物の製造方法及びトリフルオロメチル基含有化合物

    山本芳彦,黒原崇,澁谷正俊

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    Applicant:国立大学法人名古屋大学

    Application no:特願2015-116151  Date applied:2015.6

    Country of applicant:Domestic  

  2. α-ヒドロキシカルボン酸の製造方法

    澁谷正俊,山本芳彦,古川桂佑

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    Applicant:国立大学法人名古屋大学

    Application no:特願2014-128626  Date applied:2014.6

    Country of applicant:Domestic  

    1,2-ジオールからα-ヒドロキシカルボン酸への酸化手法

 

Teaching Experience (On-campus) 15

  1. Organic Chemistry 5

    2020

  2. Advanced Organic Chemistry

    2020

  3. 化学生命工学実験3

    2020

  4. 化学生命工学実験2

    2020

  5. 物質世界の認識

    2020

     詳細を見る

    分子レベルで見るにおい、味、色
    分子の左右ー薬の作用・副作用ー
    身近にある毒物
    なぜ薬で病気は治るのか

  6. 先端有機化学

    2018

  7. 有機融合実践演習

    2018

  8. 有機融合実践実習

    2018

  9. 創薬制御科学

    2018

  10. 有機化学IV

    2018

  11. 有機融合実践実習

    2013

  12. 有機融合実践演習

    2013

  13. 基盤創薬学概論

    2013

  14. 有機演習

    2013

  15. 物質世界の認識

    2013

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