Updated on 2022/04/04
博士（薬学） （ 2009.1 東北大学 ）
Organic Synthesis
associate professor
2012.4
Country：Japan
assistant professor
2009.3 - 2012.3
Country：Japan
助手
2002.10 - 2009.2
Country：Japan
Tohoku University Graduate School, Division of Pharmaceutical Sciences
2002.4 - 2002.9
Country： Japan
Tohoku University Faculty of Pharmaceutical Science
1998.4 - 2002.3
Country： Japan
日本プロセス化学会
有機合成化学協会
日本薬学会
日本化学会
American Chemical Society
Boron-Catalyzed Double Hydrofunctionalization Reactions of Unactivated Alkynes
Shibuya Masatoshi, Okamoto Masaki, Fujita Shoji, Abe Masanori, Yamamoto Yoshihiko
ACS CATALYSIS Vol. 8 ( 5 ) page： 4189-4193 2018.5
Bronsted Acid/Silane Catalytic System for Intramolecular Hydroalkoxylation and Hydroamination of Unactivated Alkynes Reviewed
Masatoshi Shibuya, Shoji Fujita, Masanori Abe, Yoshihiko Yamamoto
ACS Catalysis Vol. 7 ( 4 ) page： 2848-2852 2017.3
Keisuke Furukawa, Masatoshi Shibuya, Yoshihiko Yamamoto
Organic Letters Vol. 17 ( 9 ) page： 2282-2285 2015.4
Intramolacular Hydroalkoxylation of Unactivated Alkenes Using Silane-Iodine Catalytic System Reviewed
Shoji Fujita, Masanori Abe, Masatoshi Shibuya, Yoshihiko Yamamoto
Organic Letters Vol. 17 ( 15 ) page： 3822-3825 2015.7
Highly efficient, organocatalytic aerobic alcohol oxidation Reviewed
Masatoshi Shibuya, Yuji Osada, Yusuke Sasano, Masaki Tomizawa, Yoshiharu Iwabuchi
Journal of the American Chemical Society Vol. 133 ( 17 ) page： 6497-6500 2011.4
One-pot, two-step synthesis of unnatural alpha-amino acids involving the exhaustive aerobic oxidation of 1,2-diols
Inada Haruki, Furukawa Keisuke, Shibuya Masatoshi, Yamamoto Yoshihiko
CHEMICAL COMMUNICATIONS Vol. 55 ( 100 ) page： 15105 - 15108 2019.12
Collection of Data Variation Using a High-Throughput Image-Based Assay Platform Facilitates Data-Driven Understanding of TRPA1 Agonist Diversity
Terada Yuko, Tanaka Kenjiro, Matsuyama Minami, Fujitani Masaya, Shibuya Masatoshi, Yamamoto Yoshihiko, Kato Ryuji, Ito Keisuke
APPLIED SCIENCES-BASEL Vol. 12 ( 3 ) 2022.2
N-Hydroxyphthalimide-catalyzed chemoselective intermolecular benzylic C-H amination of unprotected arylalkanols
Shibuya Masatoshi, Orihashi Takayuki, Li Yamei, Yamamoto Yoshihiko
CHEMICAL COMMUNICATIONS Vol. 57 ( 70 ) page： 8742 - 8745 2021.9
1,2-Carbopentafluorophenylation of Alkynes: The Metallomimetic Pull-Push Reactivity of Tris(pentafluorophenyl)borane
Shibuya Masatoshi, Matsuda Miki, Yamamoto Yoshihiko
CHEMISTRY-A EUROPEAN JOURNAL Vol. 27 ( 34 ) page： 8822 - 8831 2021.6
Synthesis of Unprotected 2-Aryiglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine Reviewed
Inada Haruki, Shibuya Masatoshi, Yamamoto Yoshihiko
JOURNAL OF ORGANIC CHEMISTRY Vol. 85 ( 17 ) page： 11047 - 11059 2020.9
Nitroxyl radical-catalyzed chemoselective alcohol oxidation for the synthesis of polyfunctional molecules Invited Reviewed
Shibuya Masatoshi
TETRAHEDRON LETTERS Vol. 61 ( 8 ) 2020.2
Diastereoselective Methylation at the Congested beta-Position of a Butenolide Ring: Studies toward the Synthesis of seco-Prezizaane-Type Sesquiterpenes
Kawamura Tomoyoshi, Moriya Hirokazu, Shibuya Masatoshi, Yamamoto Yoshihiko
JOURNAL OF ORGANIC CHEMISTRY Vol. 84 ( 19 ) page： 12508 - 12519 2019.10
Boron-Catalyzed Hydroamination/Hydroallylation and Hydroamination/Hydrocyanation of Unactivated Alkynes
Shibuya Masatoshi, Kawano Shohei, Fujita Shoji, Yamamoto Yoshihiko
ASIAN JOURNAL OF ORGANIC CHEMISTRY Vol. 8 ( 7 ) page： 1075 - 1079 2019.7
SYNTHESIS OF gamma-DIFLUOROMETHYLATED TETRONATE DERIVATIVES FROM SQUARATES USING DIFLUOROMETHYLPHOSPHONATE
Yamamoto Yoshihiko, Ishida Yuki, Kurohara Takashi, Shibuya Masatoshi, Yasui Takeshi
HETEROCYCLES Vol. 99 ( 1 ) page： 363 - 378 2019.4
Direct Synthesis of Free alpha-Amino Acids by Telescoping Three-Step Process from 1,2-Diols
Inada Haruki, Shibuya Masatoshi, Yamamoto Yoshihiko
ORGANIC LETTERS Vol. 21 ( 3 ) page： 709-713 2019.2
Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway
Hibi Takahide, Ohtsuka Hokuto, Shimasaki Takafumi, Inui Shougo, Shibuya Masatoshi, Tatsukawa Hideki, Kanie Kei, Yamamoto Yoshihiko, Aiba Hirofumi
GENES TO CELLS Vol. 23 ( 8 ) page： 620-637 2018.8
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
Tsuburaya Naomi, Homma Kengo, Higuchi Tsunehiko, Balia Andrii, Yamakoshi Hiroyuki, Shibata Norio, Nakamura Seiichi, Nakagawa Hidehiko, Ikeda Shin-ichi, Umezawa Naoki, Kato Nobuki, Yokoshima Satoshi, Shibuya Masatoshi, Shimonishi Manabu, Kojima Hirotatsu, Okabe Takayoshi, Nagano Tetsuo, Naguro Isao, Imamura Keiko, Inoue Haruhisa, Fujisawa Takao, Ichijo Hidenori
NATURE COMMUNICATIONS Vol. 9 ( 1 ) page： 2668 2018.7
Synthesis of pyrroles via ruthenium-catalyzed nitrogen-transfer [2
Matsui Kazuma, Shibuya Masatoshi, Yamamoto Yoshihiko
COMMUNICATIONS CHEMISTRY Vol. 1 2018.4
Synthesis of Alkoxycarbonyldifluoromethyl-Substituted Semisquarates and Their Transformations
Kurohara Takashi, Jiyue Jiang, Shibuya Masatoshi, Yamamoto Yoshihiko
SYNTHESIS-STUTTGART Vol. 50 ( 8 ) page： 1687-1698 2018.4
The vinylogous Catellani reaction: a combined computational and experimental study
Yamamoto Y., Murayama T., Jiang J., Yasui T., Shibuya M.
CHEMICAL SCIENCE Vol. 9 ( 5 ) page： 1191-1199 2018.2
Intramolecular Hydroalkoxylation/Reduction and Hydroamination/Reduction of Unactivated Alkynes Using a Silane-Iodine Catalytic System
Fujita Shoji, Shibuya Masatoshi, Yamamoto Yoshihiko
SYNTHESIS-STUTTGART Vol. 49 ( 18 ) page： 4199-4204 2017.9
Combined Experimental and Computational Study on Ruthenium(II)Catalyzed Reactions of Diynes with Aldehydes and N,N-Dimethylformamide
Yamamoto Yoshihiko, Okude Yuta, Mori Shota, Shibuya Masatoshi
JOURNAL OF ORGANIC CHEMISTRY Vol. 82 ( 15 ) page： 7964-7973 2017.8
Selective Aerobic Oxidation of Primary Alcohols to Aldehydes
Shibuya Masatoshi, Furukawa Keisuke, Yamamoto Yoshihiko
SYNLETT Vol. 28 ( 13 ) page： 1554-1557 2017.8
Synthesis of 3-Aryl-2-(trifluoromethyl)indoles via Copper-Catalyzed Hydroarylation and Subsequent Cadogan Cyclization
Yamamoto Yoshishiko, Ohkubo Erina, Shibuya Masatoshi
ADVANCED SYNTHESIS & CATALYSIS Vol. 359 ( 10 ) page： 1747-1751 2017.5
Assembly of a Benzo-Fused Bridged Ketone Scaffold from 1,5,10-Enediynes through One-Pot Ruthenium-Catalyzed Cyclization/Iodine-Mediated Oxidative Ring Expansion
Yamamoto Yoshihiko, Nishimura Kei-ichiro, Mori Shota, Shibuya Masatoshi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 56 ( 20 ) page： 5494-5497 2017.5
Intramolecular Hydroalkoxylation/Reduction and Hydroamination/Reduction of Unactivated Alkynes Using a Silane-Iodine Catalytic System Invited Reviewed
Shoji Fujita, Masatoshi Shibuya, Yoshihiko Yamamoto
Synthesis Vol. 49 page： 4199-4204 2017.5
Bronsted Acid/Silane Catalytic System for Intramolecular Hydroalkoxylation and Hydroamination of Unactivated Alkynes (vol 7, pg 2848, 2017)
Shibuya Masatoshi, Fujita Shoji, Abe Masanori, Yamamoto Yoshihiko
ACS CATALYSIS Vol. 7 ( 5 ) page： 3356-3356 2017.5
Electrophilic Derivatization of Trifluoromethyl-Substituted Semisquarate Using Unsaturated Organosilanes and Subsequent Ring Transformations
Kurohara Takashi, Shibuya Masatoshi, Yamamoto Yoshihiko
ADVANCED SYNTHESIS & CATALYSIS Vol. 359 ( 8 ) page： 1413-1419 2017.4
Assembly of a Benzo-Fused Bridged Ketone Scaffold from 1,5,10-Endiynes through One-Pot Ruthenium-Catalyzed Cyclization/Iodine-Mediated Oxidative Ring Expansion
Yoshihiko Yamamoto, Kei-ichiro Nishimura, Shota Mori, Masatoshi Shibuya
Angewandte Chemie International Edition Vol. 56 ( 20 ) page： 5494-5497 2017.4
Selective Aerobic Oxidation of Primary Alcohols to Aldehydes Invited Reviewed
Masatoshi Shibuya, Keisuke Furukawa, Yoshihiko Yamamoto
Synlett Vol. 28 ( 13 ) page： 1154-1157 2017.3
Electrophilic Derivatization of Trifluoromethyl-Substituted Semisquarate Using Unsaturated Organosilanes and Subsequent Ring Transformations Reviewed
Takashi Kurohara, Masatoshi Shibuya, Yoshihiko Yamamoto
Advanced Synthesis & Catalysis Vol. 359 ( 8 ) page： 1413-1419 2017.2
The Anticancer Effects of Novel α-Bisabolol Derivatives Against Pancreatic Cancer
Yoshihiko Murata, Toshio Kokuryo, Yukihiro Yokoyama, Junpei Yamaguchi, Tomohiro Niwa, Masatoshi Shibuya, Yoshihiko Yamamoto and Masato Nagino
Anticancer Research Vol. 37 ( 2 ) page： 589-598 2017.2
Ruthenium-Catalyzed Cycloisomerization of 1,6-Diynes with Styryl Terminals Leading to Indenylidene Cycloalkanes
Yamamoto Yoshihiko, Nishimura Kei-ichiro, Shibuya Masatoshi
ACS CATALYSIS Vol. 7 ( 2 ) page： 1101-1107 2017.2
The Anticancer Effects of Novel alpha-Bisabolol Derivatives Against Pancreatic Cancer
Murata Yoshihiko, Kokuryo Toshio, Yokoyama Yukihiro, Yamaguchi Junpei, Miwa Tomohiro, Shibuya Masatoshi, Yamamoto Yoshihiko, Nagino Masato
ANTICANCER RESEARCH Vol. 37 ( 2 ) page： 589-598 2017.2
Ruthenium-catalyzed Hydrocarbamoylative Cyclization of 1,6-Diynes with Formamides
Mori Shota, Shibuya Masatoshi, Yamamoto Yoshihiko
CHEMISTRY LETTERS Vol. 46 ( 2 ) page： 207-210 2017.2
Ruthenium-Catalyzed Cycloisomerization of 1,6-Diynes with Styryl Terminals Leading to Indenylidene Cycloalkanes Reviewed
Yoshihiko Yamamoto, Kei-ichiro Nishimura, Masatoshi Shibuya
ACS Catalysis Vol. 7 ( 2 ) page： 1101-1107 2016.12
Ruthenium-Catalyzed Hydrocarbamoylative Cyclization of 1,6-Diynes with Formamides Reviewed
Shota Mori, Masatoshi Shibuya, and Yoshihiko Yamamoto
Chemistry Letters Vol. 46 page： 207-210 2016.11
有機ニトロキシラジカルの酸化還元特性を利用した効率的酸化システムの開発ー第一級アルコールからカルボン酸への酸化反応ー Invited Reviewed
澁谷正俊
有機合成化学協会誌 Vol. 74 ( 10 ) page： 965-974 2016.10
Chemoselective Conversion from α-Hydroxy Acids to α-Keto Acids Enabled by Nitroxyl-Radical-Catalyzed Aerobic Oxidation Reviewed
Keisuke Furukawa, Haruki Inada, Masatoshi Shibuya*, and Yoshihiko Yamamoto
Organic Letters Vol. 18 ( 17 ) page： 4230-4233 2016.8
Reagents for diverse iodosilane-mediated transformations Reviewed
Masatoshi Shibuya, Masanori Abe, Shoji Fujita, and Yoshihiko Yamamoto
Organic & Biomolecular Chemistry Vol. 14 page： 5322-5328 2016.5
Tsukasa Murayama, Masatoshi Shibuya, and Yoshihiko Yamamoto
Advanced Synthesis & Catalysis Vol. 358 page： 166-171 2016.1
Masatoshi Shibuya, Tomonori Sudo, Tomoyoshi Kawamura, Yoshihiko Yamamoto
Organic & Biomolecular Chemistry Vol. 13 page： 5862-5866 2015.4
Yoshihiko Yamamoto, Kazuma Matsui, Masatoshi Shibuya
Chemistry - A European Journal Vol. 21 ( 19 ) page： 7245-7255 2015.3
Yoshihiko Yamamoto, Shota Mori, Masatoshi Shibuya
Chemistry - A European Journal Vol. 21 page： 9093-9100 2015.3
Tsukasa Murayama, Masatoshi Shibuya, Yoshihiko Yamamoto
Advanced Synthesis & Catalysis Vol. 357 ( 4 ) page： 690-694 2015.3
Ryusuke Doi, Masatoshi Shibuya, Tsukasa Murayama, Yoshihiko Yamamoto, and Yoshiharu Iwabuchi
The Journal of Organic Chemistry Vol. 80 ( 1 ) page： 401-413 2015.1
Mechanistic Insight into Aerobic Alcohol Oxidation Using NOx-Nitroxide Catalysis Based on Catalyst Structure-Activity Relationships
Masatoshi Shibuya, Shota Nagasawa, Yuji Osada, Yoshiharu Iwabuchi
The Journal of Organic Chemistry Vol. 79 ( 21 ) page： 10256-10268 2014.10
Enantioselective Intramolecular Aza-Spiroannulation onto Benzofurans Using Chiral Rhodium Catalysis Reviewed
Takuro Shibuta, Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, Tohru Taniguchi, Kenji Monde, Yoshiharu Iwabuchi
Heterocycles Vol. 89 page： 631-639 2014.3
Yoshihiko Yamamoto, Shota Mori, Masatoshi Shibuya
Chemistry - A European Journal Vol. 19 ( 36 ) page： 12034-12041 2013.9
有機ニトロキシルラジカルの反応性制御に基づく効率的アルコール空気酸化反応の開発 Reviewed
澁谷正俊、岩渕好治
有機合成化学協会誌 Vol. 71 page： 515-525 2013.5
オキソアンモニウム塩の設計に基づく有用酸化反応システムの開発研究 Reviewed
澁谷正俊
薬学雑誌 Vol. 132 page： 1131-1143 2012.10
Organocatalytic One-pot Oxidative Cleavage of Terminal Diols to Dehomologated Carboxylic Acids Reviewed
Masatoshi Shibuya, Ryusuke Doi, Takuro Shibuta, Shun-ichiro Uesugi, Yoshiharu Iwabuchi
Organic Letters Vol. 14 ( 19 ) page： 5010-5013 2012.9
Nitroxyl Radical/PhI(OAc)2: One-Pot Oxidative Cleavage of Vicinal Diols to (Di)Carboxylic Acids Reviewed
Masatoshi Shibuya, Takuro Shibuta, Hayato Fukuda, Yoshiharu Iwabuchi
Organic Letters Vol. 14 ( 19 ) page： 5010-5013 2012.9
Catalytic Oxidation of Silyl Enol Ethers to 1,2-Diketones Employing Nitroxyl Radicals Reviewed
Masaki Hayashi, Masatoshi Shibuya, Yoshiharu Iwabuchi
Synlett Vol. 23 ( 7 ) page： 1025-1031 2012.4
Oxidation of Alcohols to Carbonyl Compounds with Diisopropyl Azodicarboxylate Catalyzed by Nitroxyl Radicals Reviewed
Vol. 77 page： 3005-3009 2012.2
Oxidation of nitroxyl radicals: electrochemical and computational studies Reviewed
Masatoshi Shibuya, Fabio Pichierri, Masaki Tomizawa, Shota Nagasawa, Iwao Suzuki, Yoshiharu Iwabuchi
Tetrahedron Letters Vol. 53 ( 16 ) page： 2070-2073 2012.2
Oxidative Conversion of Silyl Enol Ethers to alpha, beta-unsaturated Ketones Employing Oxoammnium Salts Reviewed
Masaki Hayashi, Masatoshi Shibuya, Yoshiharu Iwabuchi
Organic Letters Vol. 14 ( 1 ) page： 154-157 2012.1
9-Azanoradamantane N-Oxyl (Nor-AZADO): A Highly Active Organocatalyst for Alcohol Oxidation Reviewed
Masaki Hayashi, Yusuke Sasano, Shota Nagasawa, Masatoshi Shibuya, Yoshiharu Iwabuchi
Chemical and Pharmaceutical Bulletin Vol. 59 ( 12 ) page： 1570-1573 2011.12
Practical Preparation Methods for Highly Active Azaadamantane-Nitroxyl-Radical Type Oxidation Catalysts Reviewed
Masatoshi Shibuya, Yusuke Sasano, Masaki Tomizawa, Toshimasa Hamada, Masami Kozawa, Noriaki Nagahama, Yoshiharu Iwabuchi
Synthesis ( 21 ) page： 3418-3425 2011.7
Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apotosis via the mitochondrial pathway Reviewed
Takumi Chinen, Yoko Nagumo, Tsubasa Watanabe, Takamichi Imaizumi, Masatoshi Shibuya, Takao Kataoka, Naoki Kanoh, Yoshiharu Iwabuchi, Takeo Usui
Toxicology Letters Vol. 199 page： 341-346 2010.9
An Enantio- and Diastereocontrolled Synthesis of (-)-Salinosporamide A Reviewed
Yusuke Sato, Hayato Fukuda, Masaki Tomizawa, Tomohito Masaki, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi
Heterocycles Vol. 81 ( 10 ) page： 2239-2246 2010.8
Syntheses and Biological Evaluation of Irciniastatin A and C1-C2 Alkyne Analogue Reviewed
Tsubasa Watanabe, Takamichi Imaizumi, Takumi Chinen, Yoko Nagumo, Masatoshi Shibuya, Takeo Usui, Naoki Kanoh, Yoshiharu Iwabuchi
Organic Letters Vol. 12 ( 5 ) page： 1040-1043 2010.2
Total Synthesis and Determination of the Absolute Configuration of (-)-Idesolide Reviewed
Hiroyuki Yamakoshi, Masatoshi Shibuya, Masaki Tomizawa, Yuji Osada, Naoki Kanoh, Yoshiharu Iwabuchi
Organic Letters Vol. 12 ( 5 ) page： 980-983 2010.2
Highly Enantioseletive Intramolecular Aza-spiroannulation onto Indoles Using Chiral Rhodium Catalysis: Asymmetric Entry to the Spiro-beta-lactam Core of Chartellines Reviewed
Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi
( 41 ) page： 6264-6266 2009.9
An Expedient Route to a Potent Gastrin/CCK-B Receptor Antagonist (+)-AG-041R Reviewed
Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi
The Journal of Organic Chemistry Vol. 74 ( 19 ) page： 7522-7524 2009.8
Syntheses of naturally occurring cytotoxic[7.7]paracyclophanes, (-)-cylindrocyclophane A and its enantiomer, and implication for biologycal activity
Hiroyuki Yamakoshi, Fumiya Ikarashi, Masataka Minami, Masatoshi Shibuya, Tsutomu Sugahara, Naoki Kanoh, Hisatsugu Ohori, Hiroyuki Shibata, Yoshiharu Iwabuchi
Organic & Biomolecular Chemistry Vol. 7 ( 18 ) page： 3772-3781 2009.7
An Expeditious Entry to 9-Azabicyclo[3.3.1]nonane N-Oxyl (ABNO): Highly Active Organocatalyst for Oxidation of Alcohols Reviewed
Masatoshi Shibuya, Masaki Tomizawa, Yusuke Sasano, Yoshiharu Iwabuchi
The Journal of the Organic Chemistry Vol. 74 ( 12 ) page： 4619-4622 2009.5
Highly Enantioselective Organocatalytic Oxidative Kinetic Resolution of Secondary Alcohols Using Chirally Modified AZADOs Reviewed
Organic Letters Vol. 11 ( 8 ) page： 1829-1831 2009.3
Synthetic Studies on Daphnicyclidine A: Enantiocontrolled Construction of the BCD RIng System Reviewed
Shuhei Ikeda, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi
Organic Letters Vol. 11 ( 8 ) page： 1833-1836 2009.3
Oxoammonium salt/NaClO2; An Expedient, Catalytic System for One-pot Oxidation of Primary Alcohols to Carboxylic Aicds with Broad Substrate Applicability Reviewed
Masatoshi Shibuya, Takahisa Sato, Masaki Tomizawa, Yoshiharu Iwabuchi
Chemical Communications ( 13 ) page： 1739-1741 2009.2
Flexible Access to Monoterpenoid Indole Alkaloids Using a Cyclopentanoid Chiral Building Block Reviewed
Masato Hayashi, Keniichi Motosawa, Atsushi Satoh, Masatoshi Shibuya, Kunio Ogasawara, Yoshiharu Iwabuchi
Heterocycles Vol. 77 ( 2 ) page： 855-863 2008.11
トリス（ペンタフルオロフェニル）ボランによるフェニルアセチレンの求電子活性化を利用した三成分カップリング反応とその反応機構解析
松田実季、澁谷正俊、山本芳彦
日本薬学会 第１４１年会 2021.3.27 日本薬学会
新規有機ニトロキシラジカル型酸化触媒の開発と神経栄養因子様活性天然物の合成
2014.4 - 2016.3
科学研究費補助金 新学術領域研究・公募研究
Authorship：Principal investigator
有機ニトロキシルラジカル触媒を用いる1,2-ジオールの酸化制御法の開発とセコプレジザン型セスキテルペノイドの全合成を目的として研究を行っている
触媒設計に基づく新しい選択性を発揮するアルコール酸化反応の開発
2011.4 - 2015.3
科学研究費補助金 若手研究(A)
Authorship：Principal investigator
私たちがこれまでに開発した高活性アザアダマンタン型有機ニトロキシルラジカル型酸化触媒に，適度な立体要求性あるいは，分子認識部位を付与することによってこれまでにない選択性でポリオールの特定のアルコールのみを選択的に酸化する手法を開発する．
Development of polysubstituted heterocycles using boron catalysts
Grant number：19K06973 2019.4 - 2022.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
Development of new strategy for electrophilic acitivation of C-C multiple bonds
Grant number：16K08162 2016.4 - 2019.3
Shibuya mastoid
Authorship：Principal investigator
Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）
Methodology enabling rapid access to various molecules having a diverse structure is important for pharmaceutical sciences. A synthetic method utilizing a C-C multiple bond is relatively limited comparing with that utilizing a carbonyl group. In this study, we have developed several reactions to construct heterocycles using novel catalytic electrophilic activation methods of C-C multiple bonds. Especially, we used main group metal compounds as the catalyst.
高活性有機酸化触媒アザアダマンタン型ニトロキシラジカルの不斉反応への展開
2007.4 - 2009.3
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
新規グルタミン酸配座固定化分子の合成に基づく受容体機能探索子の創製
2006.4 - 2008.3
科学研究費補助金 特定領域研究
Authorship：Principal investigator
新規ニトロキシラジカル型アルコール酸化触媒の展開と環境調和プロセスへの展開
2005.4 - 2007.3
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
トリフルオロメチル置換セミスクアレートの製造方法，トリフルオロメチル置換セミスクアレートを起点とするトリフルオロメチル化合物の製造方法及びトリフルオロメチル基含有化合物
山本芳彦，黒原崇，澁谷正俊
α-ヒドロキシカルボン酸の製造方法
澁谷正俊，山本芳彦，古川桂佑
Organic Chemistry 5
2020
Advanced Organic Chemistry
2020
化学生命工学実験3
2020
化学生命工学実験2
2020
物質世界の認識
2020
先端有機化学
2018
有機融合実践演習
2018
有機融合実践実習
2018
創薬制御科学
2018
有機化学IV
2018
有機融合実践実習
2013
有機融合実践演習
2013
基盤創薬学概論
2013
有機演習
2013
物質世界の認識
2013
