Updated on 2021/12/27

写真a

 
YOKOSHIMA Satoshi
 
Organization
Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Organic Chemistry Professor
Cellular and Structural Physiology Institute Professor
Graduate School
Graduate School of Pharmaceutical Sciences
Undergraduate School
School of Agricultural Sciences Department of Applied Biosciences
Title
Professor

Degree 1

  1. 博士(薬学) ( 2002.3   東京大学 ) 

Research Areas 2

  1. Nanotechnology/Materials / Synthetic organic chemistry

  2. Life Science / Pharmaceutical chemistry and drug development sciences  / 天然物化学

Research History 7

  1. Nagoya University   Professor

    2017.4

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    Country:Japan

  2. Nagoya University   Associate professor

    2012.4 - 2017.3

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    Country:Japan

  3. The University of Tokyo   Associate professor

    2011.4 - 2012.3

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    Country:Japan

  4. The University of Tokyo   Lecturer

    2008.4 - 2011.3

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    Country:Japan

  5. The University of Tokyo   Assistant Professor

    2007.4 - 2008.3

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    Country:Japan

  6. The University of Tokyo   Assistant

    2004.4 - 2007.3

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    Country:Japan

  7. 三菱ウェルファーマ株式会社

    2002.4 - 2004.3

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    Country:Japan

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Professional Memberships 4

  1. 日本薬学会

  2. 有機合成化学協会

  3. 日本化学会

  4. アメリカ化学会

Committee Memberships 10

  1. 公益社団法人 日本薬学会   理事  

    2019.3 - 2021.3   

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    Committee type:Academic society

  2. 公益社団法人 日本薬学会 医薬化学部会   常任世話人  

    2018   

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    Committee type:Academic society

  3. 公益社団法人 日本薬学会 医薬化学部会   創薬ニューフロンティア検討会メンバー  

    2018   

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    Committee type:Academic society

  4. 公益社団法人 日本薬学会   東海支部幹事  

    2017   

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    Committee type:Academic society

  5. 天然有機化合物討論会   世話人  

    2017   

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    Committee type:Academic society

  6. 有機合成化学協会   編集委員  

    2014 - 2015   

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    Committee type:Academic society

  7. 天然物化学談話会   世話人代表  

    2011 - 2017   

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    Committee type:Academic society

  8. 有機合成化学協会   事業委員  

    2008 - 2012   

  9. 天然物化学談話会   世話人  

    2005 - 2017   

  10. 日本薬学会   ファルマシア トピックス小委員  

    2005 - 2007   

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    Committee type:Academic society

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Awards 7

  1. Asian Core Program Lectureship Award (China)

    2013   Asian Core Program  

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    Award type:Award from international society, conference, symposium, etc.  Country:China

  2. Asian Core Program Lectureship Award (Singapore)

    2013   Asian Core Program  

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    Award type:Award from international society, conference, symposium, etc.  Country:Singapore

  3. 日本薬学会奨励賞

    2012.3   日本薬学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  4. Thieme Journal Award 2010

    2010   Thieme  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Germany

  5. 天然物化学談話会奨励賞

    2009.7   天然物化学談話会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  6. 日本薬学会メディシナルケミストリーシンポジウムポスター賞

    2006.12   日本薬学会医薬化学部会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  7. 天然有機化合物討論会奨励賞

    2001   天然有機化合物討論会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Papers 119

  1. Photo-oxygenation by a biocompatible catalyst reduces amyloid-beta levels in Alzheimer's disease mice Reviewed

    Ozawa Shuta, Hori Yukiko, Shimizu Yusuke, Taniguchi Atsuhiko, Suzuki Takanobu, Wang Wenbo, Chiu Yung Wen, Koike Reiko, Yokoshima Satoshi, Fukuyama Tohru, Takatori Sho, Sohma Youhei, Kanai Motomu, Tomita Taisuke

    BRAIN   Vol. 144 ( 6 ) page: 1884 - 1897   2021.6

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  2. Total Synthesis of Haliclonin A Reviewed

    Jin Yuan, Orihara Kensuke, Kawagishi Fumiki, Toma Tatsuya, Fukuyama Tohru, Yokoshima Satoshi

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 60 ( 17 ) page: 9666 - 9671   2021.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.202016343

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  3. Nitrone Formation by Reaction of an Enolate with a Nitro Group Reviewed

    Shimizu Hiroaki, Yoshinaga Kohei, Yokoshima Satoshi

    ORGANIC LETTERS   Vol. 23 ( 7 ) page: 2704 - 2709   2021.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.1c00603

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  4. Copper-Mediated Conversion of Alkynes into Nitriles via Iodotriazoles Reviewed

    Kori Ryosuke, Murakami Keigo, Nishiyama Yoshitake, Toma Tatsuya, Yokoshima Satoshi

    CHEMICAL & PHARMACEUTICAL BULLETIN   Vol. 69 ( 3 ) page: 278 - 280   2021.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/cpb.c20-00787

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  5. A novel translation inhibitor, mersicarpine, inhibits S-phase progression and induces apoptosis in HL60 cells Reviewed

    Shiobara Tomoko, Nagumo Yoko, Nakajima Rie, Fukuyama Tohru, Yokoshima Satoshi, Usui Takeo

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 85 ( 1 ) page: 92 - 96   2021.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bbb/zbaa070

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  6. Synthesis of 2-Azabicyclo[3.3.1]nonanes: Lessons from Synthetic Studies of Macrocyclic Diamine Alkaloids Invited Reviewed

    Yokoshima Satoshi

    CHEMISTRY LETTERS   Vol. 50 ( 1 ) page: 96 - 102   2021.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.200695

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  7. Synthesis of Polycyclic Natural Products through Skeletal Rearrangement Invited Reviewed

    Yokoshima Satoshi

    SYNLETT   Vol. 31 ( 20 ) page: 1967 - 1975   2020.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0040-1707904

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  8. Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity Reviewed

    Natsume Noriyuki, Ozaki Kaori, Nakajima Daisuke, Yokoshima Satoshi, Teruya Toshiaki

    JOURNAL OF NATURAL PRODUCTS   Vol. 83 ( 8 ) page: 2477 - 2482   2020.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jnatprod.0c00441

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  9. Semipinacol Rearrangement Induced by Cleavage of Dibromocyclopropane Reviewed

    Kurimoto Michitaka, Nakajima Daisuke, Nishiyama Yoshitake, Yokoshima Satoshi

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   Vol. 2020 ( 27 ) page: 4108 - 4111   2020.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ejoc.202000355

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  10. Total Synthesis of Tetrodotoxin Reviewed

    Murakami Keigo, Toma Tatsuya, Fukuyama Tohru, Yokoshima Satoshi

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 59 ( 15 ) page: 6253 - 6257   2020.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201916611

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  11. Synthetic Studies on Bilobalide

    Shiogai Akihiro, Toma Tatsuya, Yokoshima Satoshi

    SYNLETT   Vol. 31 ( 3 ) page: 290 - 294   2020.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0039-1691559;

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  12. An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves

    Vong Kenward, Eda Shohei, Kadota Yasuhiro, Nasibullin Igor, Wakatake Takanori, Yokoshima Satoshi, Shirasu Ken, Tanaka Katsunori

    NATURE COMMUNICATIONS   Vol. 10 ( 1 ) page: 5746   2019.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-019-13758-2

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  13. Synthesis of Majusculamides A and B Reviewed

    Nakajima Daisuke, Sueyoshi Kosuke, Orihara Kensuke, Teruya Toshiaki, Yokoshima Satoshi

    SYNLETT   Vol. 30 ( 8 ) page: 924 - 927   2019.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0037-1611805

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  14. PREFACE TO HETEROCYCLES ISSUE HONORING THE 70TH BIRTHDAY OF PROFESSOR TOHRU FUKUYAMA

    Yokoshima Satoshi

    HETEROCYCLES   Vol. 99 ( 1 ) page: 1 - 3   2019.4

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  15. Synthetic Studies of Isoschizogamine: Alternative Preparation of the Key Intermediate.

    Hayashi N, Miura Y, Yokoshima S, Fukuyama T

    Chemical & pharmaceutical bulletin   Vol. 67 ( 1 ) page: 64 - 70   2019.1

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  16. Total Synthesis of Lycoposerramine-R

    Watanabe Shinya, Ishikawa Masatsugu, Nomura Toshimune, Fukuyama Tohru, Yokoshima Satoshi

    SYNLETT   Vol. 29 ( 18 ) page: 2377-2380   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0037-1611024

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  17. Synthetic Studies of the Daphniphyllum Alkaloids: A Cooperative Reaction of Proximal Functional Groups Forming a Tetracyclic System

    Yamada Ryosuke, Fukuyama Tohru, Yokoshima Satoshi

    ORGANIC LETTERS   Vol. 20 ( 15 ) page: 4504-4506   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.8b01800

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  18. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

    Tsuburaya Naomi, Homma Kengo, Higuchi Tsunehiko, Balia Andrii, Yamakoshi Hiroyuki, Shibata Norio, Nakamura Seiichi, Nakagawa Hidehiko, Ikeda Shin-ichi, Umezawa Naoki, Kato Nobuki, Yokoshima Satoshi, Shibuya Masatoshi, Shimonishi Manabu, Kojima Hirotatsu, Okabe Takayoshi, Nagano Tetsuo, Naguro Isao, Imamura Keiko, Inoue Haruhisa, Fujisawa Takao, Ichijo Hidenori

    NATURE COMMUNICATIONS   Vol. 9 ( 1 ) page: 2668   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-018-05127-2

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  19. Synthesis of the [7-5-5] tricyclic core of Daphniphyllum alkaloids

    Kitabayashi Yusuke, Fukuyama Tohru, Yokoshima Satoshi

    ORGANIC & BIOMOLECULAR CHEMISTRY   Vol. 16 ( 19 ) page: 3556-3559   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c8ob00859k

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  20. Synthetic Studies of Haliclonin A: Construction of the 3-Azabicyclo[3.3.1]nonane Skeleton with a Bridge that Forms the 17-Membered Ring

    Orihara Kensuke, Kawagishi Fumiki, Yokoshima Satoshi, Fukuyama Tohru

    SYNLETT   Vol. 29 ( 6 ) page: 769-772   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0037-1609150

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  21. Total synthesis of (+)-lysergic acid Reviewed

    Kanno Rentaro, Yokoshima Satoshi, Kanai Motomu, Fukuyama Tohru

    JOURNAL OF ANTIBIOTICS   Vol. 71 ( 2 ) page: 240-247   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ja.2017.80

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  22. Total Synthesis of Huperzine R Reviewed

    Nomura Toshimune, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 20 ( 1 ) page: 119-121   2018.1

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    DOI: 10.1021/acs.orglett.7b03555

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  23. Synthesis of Cardiopetaline via a Wagner-Meerwein Rearrangement without Preactivation of the Pivotal Hydroxy Group Reviewed

    Nishiyama Yoshitake, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 19 ( 21 ) page: 5833-5835   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.7b02812

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  24. Synthesis of Lycopodium Alkaloids Reviewed

    Yokoshima Satoshi

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   Vol. 75 ( 10 ) page: 1035-1044   2017.10

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  25. Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3 beta inhibitors Reviewed

    Usui Yoshihiro, Uehara Fumiaki, Hiki Shinsuke, Watanabe Kazutoshi, Tanaka Hiroshi, Shouda Aya, Yokoshima Satoshi, Aritomo Keiichi, Adachi Takashi, Fukunaga Kenji, Sunada Shinji, Nabeno Mika, Saito Ken-Ichi, Eguchi Jun-ichi, Yamagami Keiji, Asano Shouichi, Tanaka Shinji, Yuki Satoshi, Yoshii Narihiko, Fujimura Masatake, Horikawa Takashi

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   Vol. 27 ( 16 ) page: 3726-3732   2017.8

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    DOI: 10.1016/j.bmcl.2017.06.078

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  26. Total Synthesis of Huperzine Q Reviewed

    Tanimura Shun, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 19 ( 13 ) page: 3684-3686   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.7b01633

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  27. High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway Reviewed

    Ishii Seiji, Fukui Kenji, Yokoshima Satoshi, Kumagai Kazuo, Beniyama Youko, Kodama Tetsuya, Fukuyama Tohru, Okabe Takayoshi, Nagano Tetsuo, Kojima Hirotatsu, Yano Takato

    SCIENTIFIC REPORTS   Vol. 7   2017.6

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    DOI: 10.1038/s41598-017-03567-2

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  28. Total Syntheses of Aurachins A and B Reviewed

    Hattori Haruhiko, Yokoshima Satoshi, Fukuyama Tohru

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 56 ( 24 ) page: 6980-6983   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201702204

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  29. Total Synthesis of (-)-Morphine Reviewed

    Umihara Hirotatsu, Yokoshima Satoshi, Inoue Masayuki, Fukuyama Tohru

    CHEMISTRY-A EUROPEAN JOURNAL   Vol. 23 ( 29 ) page: 6993-6995   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201701438

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  30. Total Synthesis of (-)-Tetrodotoxin and 11-norTTX-6(R)-ol Reviewed

    Maehara Tomoaki, Motoyama Keisuke, Toma Tatsuya, Yokoshima Satoshi, Fukuyama Tohru

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 56 ( 6 ) page: 1549-1552   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201611574

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  31. Total Synthesis of Lycopalhine A Reviewed

    Ochi Yuji, Yokoshima Satoshi, Fukuyama Tohru

    SYNTHESIS-STUTTGART   Vol. 49 ( 1 ) page: 96-114   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0036-1588878

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  32. Chemical Transformation of an Intermediate in the Synthesis of Huperzine A, Leading to a Diverse Array of Molecules Reviewed

    Yokoshima Satoshi, Ishikawa Masatsugu, Beniyama Youko, Fukuyama Tohru

    CHEMICAL & PHARMACEUTICAL BULLETIN   Vol. 64 ( 10 ) page: 1528-1531   2016.10

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  33. Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation Reviewed

    Ota Yu, Chinen Takumi, Yoshida Keisuke, Kudo Shun, Nagumo Yoko, Shiwa Yuh, Yamada Ryosuke, Umihara Hirotatsu, Iwasaki Kotaro, Masumoto Hiroshi, Yokoshima Satoshi, Yoshikawa Hirofumi, Fukuyama Tohru, Kobayashi Junichi, Usui Takeo

    CHEMBIOCHEM   Vol. 17 ( 17 ) page: 1616-1620   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbic.201600075

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  34. Morphological Evaluation of Nonlabeled Cells to Detect Stimulation of Nerve Growth Factor Expression by Lyconadin B Reviewed

    Kawai Shun, Sasaki Hiroto, Okada Norihiro, Kanie Kei, Yokoshima Satoshi, Fukuyama Tohru, Honda Hiroyuki, Kato Ryuji

    JOURNAL OF BIOMOLECULAR SCREENING   Vol. 21 ( 8 ) page: 795-803   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1087057116645500

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  35. BIN1 regulates BACE1 intracellular trafficking and amyloid-beta production Reviewed

    Miyagawa Toji, Ebinuma Ihori, Morohashi Yuichi, Hori Yukiko, Chang Mee Young, Hattori Haruhiko, Maehara Tomoaki, Yokoshima Satoshi, Fukuyama Tohru, Tsuji Shoji, Iwatsubo Takeshi, Prendergast George C., Tomita Taisuke

    HUMAN MOLECULAR GENETICS   Vol. 25 ( 14 ) page: 2948-2958   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/hmg/ddw146

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  36. Conversion of Vindoline into 11-Mesyloxytabersonine Reviewed

    Han-ya Yuki, Inui Tomohiko, Yokoshima Satoshi, Tokuyama Hidetoshi, Fukuyama Tohru

    CHEMICAL & PHARMACEUTICAL BULLETIN   Vol. 64 ( 7 ) page: 800-804   2016.7

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  37. Total Synthesis of (-)-Cardiopetaline Reviewed

    Nishiyama Yoshitake, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 18 ( 10 ) page: 2359-2362   2016.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.6b00789

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  38. Total Synthesis of (-)-Daphenylline Reviewed

    Yamada Ryosuke, Adachi Yohei, Yokoshima Satoshi, Fukuyama Tohru

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 55 ( 20 ) page: 6067-6070   2016.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201601958

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  39. Total Synthesis of Lycopalhine A Reviewed

    Ochi Yuji, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 18 ( 6 ) page: 1494-1496   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.6b00338

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  40. Synthetic Studies on Huperzine R: Construction of the 1-Azabicyclo[5.4.3]tetradec-6-ene Core Reviewed

    Kumazaki Hiroshi, Nakajima Rie, Bessho Yuka, Yokoshima Satoshi, Fukuyama Tohru

    SYNLETT   Vol. 26 ( 15 ) page: 2131-2134   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0034-1380425

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  41. Conversion of Ester Moieties to 4-Bromophenyl Groups via Electrocyclic Reaction of Dibromocyclopropanes Reviewed

    Ueda Kyosuke, Umihara Hirotatsu, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 17 ( 13 ) page: 3191-3193   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.5b01351

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  42. Synthetic Studies on Plakinidines Reviewed

    Komori Takashi, Yokoshima Satoshi, Fukuyama Tohru

    SYNLETT   Vol. 26 ( 11 ) page: 1537-1540   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0034-1380689

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  43. Formal Synthesis of Sarain A: Intramolecular Cycloaddition of an Eight-Membered Cyclic Nitrone to Construct the 2-Azabicyclo-[3.3.1]nonane Framework Reviewed

    Higo Takuya, Ukegawa Tomoya, Yokoshima Satoshi, Fukuyama Tohru

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 54 ( 25 ) page: 7367-7370   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201501633

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  44. Asymmetric synthesis of 2-arylpiperazines Reviewed

    Yokoshima Satoshi, Watanabe Kazutoshi, Uehara Fumiaki, Usui Yoshihiro, Tanaka Hiroshi

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   Vol. 24 ( 24 ) page: 5749-5751   2014.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmcl.2014.10.047

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  45. Synthesis of (-)-Oxycodone Reviewed

    Kimishima Atsushi, Umihara Hirotatsu, Mizoguchi Akihiro, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 16 ( 23 ) page: 6244-6247   2014.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ol503175n

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  46. Total Synthesis of Lysergic Acid (vol 16, pg 1269, 2014) Reviewed

    Umezaki Satoshi, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 16 ( 17 ) page: 4692-4692   2014.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ol502316x

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  47. A Unified Strategy for Kainoid Synthesis Reviewed

    Fujii Masaya, Yokoshima Satoshi, Fukuyama Tohru

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   ( 22 ) page: 4823-4836   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ejoc.201402452

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  48. Allosteric regulation of gamma-secretase activity by a phenylimidazole-type gamma-secretase modulator Reviewed

    Takeo Koji, Tanimura Shun, Shinoda Takehiro, Osawa Satoko, Zahariev Ivan Krasmirov, Takegami Naoki, Ishizuka-Katsura Yoshiko, Shinya Naoko, Takagi-Niidome Shizuka, Tominaga Aya, Ohsawa Noboru, Kimura-Someya Tomomi, Shirouzu Mikako, Yokoshima Satoshi, Yokoyama Shigeyuki, Fukuyama Tohru, Tomita Taisuke, Iwatsubo Takeshi

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 111 ( 29 ) page: 10544-10549   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1402171111

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  49. New photocleavable linker: alpha-Thioacetophenone-type linker Reviewed

    Yonezawa Hirotaka, Nishiyama Yoshitake, Takeo Koji, Iwatsubo Takeshi, Tomita Taisuke, Yokoshima Satoshi, Fukuyama Tohru

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   Vol. 24 ( 13 ) page: 2831-2833   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmcl.2014.04.104

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  50. Total Synthesis of (-)-Lepistine Reviewed

    Kitabayashi Yusuke, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 16 ( 11 ) page: 2862-2864   2014.6

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    DOI: 10.1021/ol5010033

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  51. Total Synthesis of (-)-Lepenine Reviewed

    Nishiyama Yoshitake, Han-ya Yuki, Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 136 ( 18 ) page: 6598-6601   2014.5

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    DOI: 10.1021/ja503023h

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  52. Total Synthesis of (-)-Mersicarpine (vol 132, pg 1236, 2010) Reviewed

    Nakajima Rie, Ogino Tsuyoshi, Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 136 ( 15 ) page: 5816-5816   2014.4

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    DOI: 10.1021/ja502536z

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  53. Concise Total Synthesis of (+)-Lyconadin A (vol 133, pg 418, 2011) Reviewed

    Nishimura Takuya, Unni Aditya K., Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 136 ( 15 ) page: 5818-5818   2014.4

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    DOI: 10.1021/ja502539r

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  54. Total Synthesis of Ecteinascidin 743 (vol 135, pg 13684, 2013) Reviewed

    Kawagishi Fumiki, Toma Tatsuya, Inui Tomohiko, Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 136 ( 15 ) page: 5815-5815   2014.4

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    DOI: 10.1021/ja502534m

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  55. Total Syntheses of Lyconadins A-C (vol 135, pg 3243, 2013) Reviewed

    Nishimura Takuya, Unni Aditya K., Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 136 ( 15 ) page: 5817-5817   2014.4

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    DOI: 10.1021/ja5025386

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  56. Correction of Synthetic Studies on Chartelline C: Stereoselective Construction of the Core Skeleton Reviewed

    Iwasaki Kotaro, Kanno Rentaro, Morimoto Toshiharu, Yamashita Tohru, Yokoshima Satoshi, Fukuyama Tohru

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 53 ( 15 ) page: 3768-3768   2014.4

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    DOI: 10.1002/anie.201401113

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  57. Total Synthesis of (-)-Huperzine A (vol 11, pg 5354, 2009) Reviewed

    Koshiba Takahiro, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 16 ( 4 ) page: 1270-1270   2014.2

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    DOI: 10.1021/ol500160t

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  58. Total Synthesis of Lysergic Acid (vol 15, pg 4230, 2013) Reviewed

    Umezaki Satoshi, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 16 ( 4 ) page: 1269-1269   2014.2

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    DOI: 10.1021/ol500159h

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  59. (1-Nosyl-5-nitroindol-3-yl)methyl Ester: A Novel Protective Group for Carboxylic Acids (vol 10, pg 2601, 2008) Reviewed

    Nishimura Takuya, Yamada Kouhei, Takebe Tohru, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 16 ( 4 ) page: 1268-1268   2014.2

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    DOI: 10.1021/ol403738z

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  60. 2-Pyridone Synthesis Using 2-(Phenylsulfinyl)acetamide (vol 15, pg 232, 2013) Reviewed

    Fujii Masaya, Nishimura Takuya, Koshiba Takahiro, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 16 ( 4 ) page: 1272-1272   2014.2

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    DOI: 10.1021/ol500162b

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  61. Total Synthesis of (-)-Histrionicotoxin (vol 13, pg 4466, 2011) Reviewed

    Adachi Yohei, Kamei Noriyuki, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 16 ( 4 ) page: 1273-1273   2014.2

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    DOI: 10.1021/ol5001632

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  62. Binding of longer A beta to transmembrane domain 1 of presenilin 1 impacts on A beta 42 generation Reviewed

    Ohki Yu, Shimada Naoaki, Tominaga Aya, Osawa Satoko, Higo Takuya, Yokoshima Satoshi, Fukuyama Tohru, Tomita Taisuke, Iwatsubo Takeshi

    MOLECULAR NEURODEGENERATION   Vol. 9   2014.1

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    DOI: 10.1186/1750-1326-9-7

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  63. Total Synthesis of Ecteinascidin 743 Reviewed

    Kawagishi Fumiki, Toma Tatsuya, Inui Tomohiko, Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 135 ( 37 ) page: 13684-13687   2013.9

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    DOI: 10.1021/ja408034x

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  64. Total Synthesis of Lysergic Acid Reviewed

    Umezaki Satoshi, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 15 ( 16 ) page: 4230-4233   2013.8

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    DOI: 10.1021/ol4019562

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  65. Synthesis of Natural Products with Polycyclic Systems Reviewed

    Yokoshima Satoshi

    CHEMICAL & PHARMACEUTICAL BULLETIN   Vol. 61 ( 3 ) page: 251-257   2013.3

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  66. Effect of Helical Conformation and Side Chain Structure on gamma-Secretase Inhibition by beta-Peptide Foldamers: Insight into Substrate Recognition Reviewed

    Imamura Yuki, Umezawa Naoki, Osawa Satoko, Shimada Naoaki, Higo Takuya, Yokoshima Satoshi, Fukuyama Tohru, Iwatsubo Takeshi, Kato Nobuki, Tomita Taisuke, Higuchi Tsunehiko

    JOURNAL OF MEDICINAL CHEMISTRY   Vol. 56 ( 4 ) page: 1443-1454   2013.2

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    DOI: 10.1021/jm301306c

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  67. Total Syntheses of Lyconadins A-C Reviewed

    Nishimura Takuya, Unni Aditya K., Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 135 ( 8 ) page: 3243-3247   2013.2

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    DOI: 10.1021/ja312065m

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  68. 2-Pyridone Synthesis Using 2-(Phenylsulfinyl)acetamide Reviewed

    Fujii Masaya, Nishimura Takuya, Koshiba Takahiro, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 15 ( 1 ) page: 232-234   2013.1

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    DOI: 10.1021/ol303320c

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  69. Activity-Dependent Proteolytic Cleavage of Neuroligin-1 Reviewed

    Suzuki Kunimichi, Hayashi Yukari, Nakahara Soichiro, Kumazaki Hiroshi, Prox Johannes, Horiuchi Keisuke, Zeng Mingshuo, Tanimura Shun, Nishiyama Yoshitake, Osawa Satoko, Sehara-Fujisawa Atsuko, Saftig Paul, Yokoshima Satoshi, Fukuyama Tohru, Matsuki Norio, Koyama Ryuta, Tomita Taisuke, Iwatsubo Takeshi

    NEURON   Vol. 76 ( 2 ) page: 410-422   2012.10

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    DOI: 10.1016/j.neuron.2012.10.003

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  70. Synthetic Studies toward Ecteinascidin 743 (Trabectedin) Reviewed

    Imai Takahiro, Nakata Hiyoku, Yokoshima Satoshi, Fukuyama Tohru

    SYNTHESIS-STUTTGART   Vol. 44 ( 17 ) page: 2743-2753   2012.9

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    DOI: 10.1055/s-0032-1316579

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  71. Total Synthesis of (-)-Lemonomycin Reviewed

    Yoshida Atsushi, Akaiwa Michinori, Asakawa Tomohiro, Hamashima Yoshitaka, Yokoshima Satoshi, Fukuyama Tohru, Kan Toshiyuki

    CHEMISTRY-A EUROPEAN JOURNAL   Vol. 18 ( 36 ) page: 11192-11195   2012.9

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    DOI: 10.1002/chem.201202073

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  72. Total Synthesis of (-)-Isoschizogamine Reviewed

    Miura Yusuke, Hayashi Noriyuki, Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 134 ( 29 ) page: 11995-11997   2012.7

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    DOI: 10.1021/ja305856q

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  73. A Practical Preparation of Highly Versatile N-Acylpyrroles from 2,4,4-Trimethoxybutan-1-amine Reviewed

    Maehara Tomoaki, Kanno Rentaro, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 14 ( 7 ) page: 1946-1948   2012.4

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    DOI: 10.1021/ol3005613

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  74. Total Synthesis of (-)-Anisatin Reviewed

    Ogura Akihiro, Yamada Kohei, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 14 ( 6 ) page: 1632-1635   2012.3

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    DOI: 10.1021/ol300390k

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  75. Identification of novel deoxyribofuranosyl indole antimicrobial agents Reviewed

    Paudel Atmika, Hamamoto Hiroshi, Kobayashi Yoshihisa, Yokoshima Satoshi, Fukuyama Tohru, Sekimizu Kazuhisa

    JOURNAL OF ANTIBIOTICS   Vol. 65 ( 2 ) page: 53-57   2012.2

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    DOI: 10.1038/ja.2011.110

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  76. Total synthesis of gelsemoxonine Reviewed

    Shimokawa Jun, Harada Takaaki, Yokoshima Satoshi, Fukuyama Tohru

    PURE AND APPLIED CHEMISTRY   Vol. 84 ( 7 ) page: 1643-1650   2012

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    DOI: 10.1351/PAC-CON-11-10-25

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  77. Total Synthesis of (-)-Lycoposerramine-S Reviewed

    Shimada Naoaki, Abe Yuzo, Yokoshima Satoshi, Fukuyama Tohru

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 51 ( 47 ) page: 11824-11826   2012

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    DOI: 10.1002/anie.201206863

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  78. Synthetic Studies on Chartelline C: Stereoselective Construction of the Core Skeleton Reviewed

    Iwasaki Kotaro, Kanno Rentaro, Morimoto Toshiharu, Yamashita Tohru, Yokoshima Satoshi, Fukuyama Tohru

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 51 ( 36 ) page: 9160-9163   2012

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    DOI: 10.1002/anie.201204726

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  79. A Practical Synthesis of (-)-Kainic Acid Reviewed

    Takita Satoshi, Yokoshima Satoshi, Fukuyama Tohru

    SYNTHESIS-STUTTGART   ( 23 ) page: 3848-3858   2011.12

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    DOI: 10.1055/s-0031-1289570

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  80. Phenylpiperidine-type gamma-secretase modulators target the transmembrane domain 1 of presenilin 1 Reviewed

    Ohki Yu, Higo Takuya, Uemura Kengo, Shimada Naoaki, Osawa Satoko, Berezovska Oksana, Yokoshima Satoshi, Fukuyama Tohru, Tomita Taisuke, Iwatsubo Takeshi

    EMBO JOURNAL   Vol. 30 ( 23 ) page: 4815-4824   2011.11

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    DOI: 10.1038/emboj.2011.372

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  81. Total Synthesis of Gelsemoxonine Reviewed

    Shimokawa Jun, Harada Takaaki, Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 133 ( 44 ) page: 17634-17637   2011.11

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    DOI: 10.1021/ja208617c

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  82. Practical synthesis of (-)-kainic acid Reviewed

    Takita Satoshi, Yokoshima Satoshi, Fukuyama Tohru

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 242   page: .   2011.8

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  83. Total Synthesis of (-)-Histrionicotoxin Reviewed

    Adachi Yohei, Kamei Noriyuki, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 13 ( 16 ) page: 4446-4449   2011.8

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    DOI: 10.1021/ol2018032

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  84. Copper-Mediated Aryl Amination: In Situ Generation of an Active Copper(I) Species Reviewed

    Komori Takashi, Satoh Nobuhiro, Yokoshima Satoshi, Fukuyama Tohru

    SYNLETT   ( 13 ) page: 1859-1862   2011.8

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    DOI: 10.1055/s-0030-1260954

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  85. Total Synthesis of (-)-Salinosporamide A Reviewed

    Satoh Nobuhiro, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 13 ( 12 ) page: 3028-3031   2011.6

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    DOI: 10.1021/ol200886j

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  86. BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate Reviewed

    Takasugi Nobumasa, Sasaki Tomoki, Suzuki Kunimichi, Osawa Satoko, Isshiki Hayato, Hori Yukiko, Shimada Naoaki, Higo Takuya, Yokoshima Satoshi, Fukuyama Tohru, Lee Virginia M. -Y., Trojanowski John Q., Tomita Taisuke, Iwatsubo Takeshi

    JOURNAL OF NEUROSCIENCE   Vol. 31 ( 18 ) page: 6850-6857   2011.5

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    DOI: 10.1523/JNEUROSCI.6467-10.2011

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  87. A Practical Synthesis of (-)-Kainic Acid Reviewed

    Takita Satoshi, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 13 ( 8 ) page: 2068-2070   2011.4

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    DOI: 10.1021/ol200434a

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  88. Concise Total Synthesis of (+)-Lyconadin A Reviewed

    Nishimura Takuya, Unni Aditya K., Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 133 ( 3 ) page: 418-419   2011.1

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    DOI: 10.1021/ja109516f

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  89. Let's Challenge Reviewed

    Yokoshima Satoshi

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   Vol. 68 ( 12 ) page: 1323-1324   2010.12

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  90. Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker (vol 19, pg 6869, 2009) Reviewed

    Yokoshima Satoshi, Abe Yuzo, Watanabe Naoto, Kita Yoichi, Kan Toshiyuki, Iwatsubo Takeshi, Tomita Taisuke, Fukuyama Tohru

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   Vol. 20 ( 5 ) page: 1798-1799   2010.3

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    DOI: 10.1016/j.bmcl.2010.01.025

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  91. Total Synthesis of (-)-Mersicarpine Reviewed

    Nakajima Rie, Ogino Tsuyoshi, Yokoshima Satoshi, Fukuyama Tohru

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 132 ( 4 ) page: 1236-+   2010.2

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    DOI: 10.1021/ja9103233

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  92. Total Synthesis of (-)-Morphine Reviewed

    Koizumi Hifumi, Yokoshima Satoshi, Fukuyama Tohru

    CHEMISTRY-AN ASIAN JOURNAL   Vol. 5 ( 10 ) page: 2192-2198   2010

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    DOI: 10.1002/asia.201000458

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  93. Total Synthesis of (+)-Vinblastine: Control of the Stereochemistry at C18 ' Reviewed

    Yokoshima Satoshi, Tokuyama Hidetoshi, Fukuyama Tohru

    CHEMICAL RECORD   Vol. 10 ( 2 ) page: 101-118   2010

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    DOI: 10.1002/tcr.200900025

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  94. Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker Reviewed

    Yokoshima Satoshi, Abe Yuzo, Watanabe Naoto, Kita Yoichi, Kan Toshiyuki, Iwatsubo Takeshi, Tomita Taisuke, Fukuyama Tohru

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   Vol. 19 ( 24 ) page: 6869-6871   2009.12

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    DOI: 10.1016/j.bmcl.2009.10.086

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  95. Total Synthesis of (-)-Huperzine A Reviewed

    Koshiba Takahiro, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 11 ( 22 ) page: 5354-5356   2009.11

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    DOI: 10.1021/ol9022408

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  96. A practical synthesis of (-)-oseltamivir Reviewed

    Satoh Nobuhiro, Akiba Takahiro, Yokoshima Satoshi, Fukuyama Tohru

    TETRAHEDRON   Vol. 65 ( 16 ) page: 3239-3245   2009.4

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    DOI: 10.1016/j.tet.2008.09.103

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  97. SYNTHETIC STUDIES TOWARD (+)-LYSERGIC ACID: CONSTRUCTION OF THE TETRACYCLIC ERGOLINE SKELETON Reviewed

    Inoue Tohru, Yokoshima Satoshi, Fukuyama Tohru

    HETEROCYCLES   Vol. 79   page: 373-378   2009.4

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    DOI: 10.3987/COM-08-S(D)42

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  98. TOTAL SYNTHESIS OF (+/-)-MORPHINE Reviewed

    Uchida Kenji, Yokoshima Satoshi, Kan Toshiyuki, Fukuyama Tohru

    HETEROCYCLES   Vol. 77 ( 2 ) page: 1219-1234   2009.2

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    DOI: 10.3987/COM-08-S(F)103

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  99. A SIMPLE CHIRAL TEMPLATE FOR THE SYNTHESIS OF FUNCTIONALIZED alpha-ARYLGLYCINE DERIVATIVES Reviewed

    Nakata Hiyoku, Imai Takahiro, Yokoshima Satoshi, Fukuyama Tohru

    HETEROCYCLES   Vol. 76 ( 1 ) page: 747-757   2008.9

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  100. (1-nosyl-5-nitroindol-3-yl)methyl ester: A novel protective group for carboxylic acids Reviewed

    Nishimura Takuya, Yamada Kouhei, Takebe Tohru, Yokoshima Satoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 10 ( 12 ) page: 2601-2604   2008.6

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    DOI: 10.1021/ol8008655

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  101. Synthesis of eudistomin C and E: Improved preparation of the indole unit Reviewed

    Yamagishi Hiroaki, Matsumoto Koji, Iwasaki Kotaro, Miyazaki Tohru, Yokoshima Satoshi, Tokuyama Hidetoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 10 ( 12 ) page: 2369-2372   2008.6

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    DOI: 10.1021/ol800527p

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  102. Oseltamivir enhances hippocampal network synchronization Reviewed

    Usami Atsushi, Sasaki Takuya, Satoh Nobuhiro, Akiba Takahiro, Yokoshima Satoshi, Fukuyama Tohru, Yamatsugu Kenzo, Kanai Motomu, Shibasaki Masakatsu, Matsuki Norio, Ikegaya Yuji

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 106 ( 4 ) page: 659-662   2008.4

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    DOI: 10.1254/jphs.SC0070467

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  103. Oseltamivir induces spike synchronization in hippocampal networks Reviewed

    Usami Atsushi, Sasaki Takuya, Satoh Nobuhiro, Akiba Takahiro, Yokoshima Satoshi, Fukuyama Tohru, Yamatsugu Kenzo, Kanai Motomu, Shibasaki Masakatsu, Matsuki Norio, Ikegaya Yuji

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 106   page: 173P-173P   2008

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  104. Synthesis of (+)-vinblastine and its analogues Reviewed

    Miyazaki Tohru, Yokoshirna Satoshi, Simizu Siro, Osada Hiroyuki, Tokuyama Hidetoshi, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 9 ( 23 ) page: 4737-4740   2007.11

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    DOI: 10.1021/ol702040y

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  105. A practical synthesis of (-)-Oseltamivir Reviewed

    Satoh Nobuhiro, Akiba Takahiro, Yokoshima Satoshi, Fukuyama Tohru

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 46 ( 30 ) page: 5734-5736   2007

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    DOI: 10.1002/anie.200701754

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  106. Diastereoselective synthesis of atropisomeric 3-(2-substituted aryl)quinazolin-4-ones and their stereochemical properties Reviewed

    Tokitoh Takashi, Kobayashi Toshitake, Nakada Eisuke, Inoue Tohru, Yokoshima Satoshi, Takahashi Hideyo, Natsugari Hideaki

    HETEROCYCLES   Vol. 70   page: 93-+   2006.12

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  107. Total synthesis of (+/-)-morphine Reviewed

    Uchida Kenji, Yokoshima Satoshi, Kan Toshiyuki, Fukuyama Tohru

    ORGANIC LETTERS   Vol. 8 ( 23 ) page: 5311-5313   2006.11

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    DOI: 10.1021/ol062112m

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  108. Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors Reviewed

    Fuwa Haruhiko, Hiromoto Kenichi, Takahashi Yasuko, Yokoshima Satoshi, Kan Toshiyuki, Fukuyama Tohru, Iwatsubo Takeshi, Tomita Taisuke, Natsugari Hideaki

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   Vol. 16 ( 16 ) page: 4184-4189   2006.8

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    DOI: 10.1016/j.bmcl.2006.05.091

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  109. Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates Reviewed

    Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T, Tomita T, Natsugari H, Fukuyama T

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   Vol. 16 ( 14 ) page: 3813-3816   2006.7

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    DOI: 10.1016/j.bmcl.2006.04.025

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  110. Stereocontrolled total synthesis of (+)-vincristine Reviewed

    Kuboyama T, Yokoshima S, Tokuyama H, Fukuyama T

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 101 ( 33 ) page: 11966-11970   2004.8

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    DOI: 10.1073/pnas.0401323101

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  111. A novel palladium-catalyzed coupling of thiol esters with 1-alkynes Reviewed

    Tokuyama H, Miyazaki T, Yokoshima S, Fukuyama T

    SYNLETT   ( 10 ) page: 1512-1514   2003.8

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    Web of Science

  112. Stereocontrolled total synthesis of (+)-vinblastine Reviewed

    Yokoshima S, Ueda T, Kobayashi S, Sato A, Kuboyama T, Tokuyama H, Fukuyama T

    PURE AND APPLIED CHEMISTRY   Vol. 75 ( 1 ) page: 29-38   2003.1

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    Web of Science

  113. Reduction of ethanethiol esters to aldehydes Reviewed

    Tokuyama H, Yokoshima S, Lin SC, Li LP, Fukuyama T

    SYNTHESIS-STUTTGART   ( 8 ) page: 1121-1123   2002.6

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  114. Stereocontrolled total synthesis of (+)-vinblastine Reviewed

    Yokoshima S, Ueda T, Kobayashi S, Sato A, Kuboyama T, Tokuyama H, Fukuyama T

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 124 ( 10 ) page: 2137-2139   2002.3

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    DOI: 10.1021/ja0177049

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  115. A novel oxidative transformation of alpha-aminonitriles to amides Reviewed

    Yokoshima S, Kubo T, Tokuyama H, Fukuyama T

    CHEMISTRY LETTERS   ( 2 ) page: 122-123   2002.2

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  116. Dogger Bank Itch revisited: isolation of (2-hydroxyethyl) dimethylsulfoxonium chloride as a cytotoxic constituent from the marine sponge Theonella aff. mirabilis Reviewed

    Warabi K, Nakao Y, Matsunaga S, Fukuyama T, Kan T, Yokoshima S, Fusetani N

    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY   Vol. 128 ( 1 ) page: 27-30   2001.1

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  117. Enantioselective total synthesis of (+)-gelsemine: Determination of its absolute configuration Reviewed

    Yokoshima S, Tokuyama H, Fukuyama T

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 39 ( 22 ) page: 4073-4075   2000

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  118. A novel ketone synthesis by a palladium-catalyzed reaction of thiol esters and organozinc reagents Reviewed

    Tokuyama H, Yokoshima S, Yamashita T, Fukuyama T

    TETRAHEDRON LETTERS   Vol. 39 ( 20 ) page: 3189-3192   1998.5

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    Web of Science

  119. Facile palladium-mediated conversion of ethanethiol esters to aldehydes and ketones Reviewed

    Tokuyama H, Yokoshima S, Yamashita T, Lin SC, Li LP, Fukuyama T

    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY   Vol. 9 ( 4 ) page: 381-387   1998

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Books 6

  1. 天然物の化学II 自然からの贈り物

    上村大輔 他( Role: Joint author)

    東京化学同人  2018.7 

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    Language:Japanese Book type:General book, introductory book for general audience

  2. 天然有機化合物の全合成

    井上将行 他( Role: Sole author)

    化学同人  2018.3 

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    Language:Japanese Book type:Scholarly book

  3. アルカロイドの科学

    高山廣光 他( Role: Sole author)

    化学同人  2017.8 

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    Language:Japanese Book type:Scholarly book

  4. 天然物の化学 ー魅力と展望ー

    上村大輔 他( Role: Joint author)

    東京化学同人  2016.6 

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    Language:Japanese Book type:General book, introductory book for general audience

  5. 天然物合成で活躍した反応

    菅敏幸、林雄二郎、長澤和夫、福山透、岡野健太郎、庄司満、高橋圭介、早川一郎、山口潤一郎、山下修治、横島聡、吉村文彦( Role: Joint author)

    化学同人  2011.10  ( ISBN:978-4-7598-1479-8

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    Language:Japanese

  6. 天然物全合成の最新動向

    北泰行 他( Role: Sole author)

    シーエムシー出版  2009.11 

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KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. Development of monoclonal antibody targeting CHRNB2 to treat gastric cancer

    Grant number:20H03750  2020.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  2. 多環式含窒素コア骨格と大環状構造を特徴とする海洋性中分子の合成研究

    Grant number:18H04399  2018.4 - 2020.3

    新学術領域研究(研究領域提案型)

    横島 聡

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    Authorship:Principal investigator 

    Grant amount:\5200000 ( Direct Cost: \4000000 、 Indirect Cost:\1200000 )

    ハリクロニンAの合成研究:立体選択的アルキル化、閉環メタセシス、および分子内シクロプロパン化反応を鍵工程とした合成経路を用いて、大員環をもつアザビシクロ[3.3.1]ノナン骨格の構築を行い、さらなる検討に必要な十分量の基質の合成を行った。得られた化合物の第一級アルコール部位を酸化することでアルデヒドを得たのち、エナミンを経由して立体選択的にフェニルセレネニル基を導入した。過酸化水素を用いてセレノキシドへと酸化したところ、シン脱離が円滑に進行し、望みの幾何異性をもつ不飽和アルデヒドを得ることができた。本アルデヒドにアリルボロン酸エステルをさせたところ、高い立体選択性でアリル基の導入を行うことができ、天然物と同一の立体化学をもつ第二級アルコールを得た。導入したアリル基の末端オレフィン部位と、既に導入されていた窒素原子上の側鎖の末端オレフィン部位を閉環メタセシスにより連結し、2つ目の大員環を構築した。さらに脱保護、ホルミル基の導入、ケトンへの酸化を含む数工程で、ハリクロニンAへと導いた。デンサニンBの合成研究:不斉ディールス・アルダー反応、ジブロモシクロプロパンの開裂による環拡大反応、2-ニトロベンゼンスルホンアミド部位とアルコール部位との分子内置換反応を用いて、大員環をもつシクロヘプテノンを得た。シクロヘプテノン部位をあしがかりとしたピロリジン環の構築について検討を行ったところ、アゾメチンイリドの環化付加反応により、望みとするピロリジン環を構築可能であることが明らかとなった。すなわち上記シクロヘプテノンに対して、アセトニトリル中フッ化リチウム存在下、アゾメチンイリドの前駆体としてN-ベンジル-N-メトキシメチルトリメチルシリルメチルアミンを作用させ、加熱したところ、アゾメチンイリドの環化付加反応が進行し、ピロリジン環を含む三環性化合物を得ることに成功した。
    令和元年度が最終年度であるため、記入しない。
    令和元年度が最終年度であるため、記入しない。

  3. 多官能性高度縮環天然物の合成研究

    Grant number:17H01523  2017.4 - 2022.3

    科学研究費助成事業  基盤研究(A)

    横島 聡

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    Authorship:Principal investigator 

    Grant amount:\41080000 ( Direct Cost: \31600000 、 Indirect Cost:\9480000 )

    以下に概要を示すものを含む天然有機化合物の合成研究を行った。ダフニフィラムアルカロイドの合成研究:四置換二重結合を含む[7-5-5]三環性骨格の構築にあたり、窒素官能基の転位反応を用いた合成経路を立案した。すなわち第三級炭素に結合した窒素原子の隣接位に二重結合を配置させておき、窒素官能基の転位反応を行うことで、所望の位置に四置換二重結合を導入するというものである。その窒素原子を含む官能基を構築するにあたり、分子内環化付加を用いることとした。マロン酸を原料として用い、異なる2種類のハロゲン化アルキルと順次反応させることで、第4級炭素をもつ化合物を合成した。マロン酸部位を還元して得られるアルコールから前駆体へと導き、環化付加反応を試みた。その結果、環化付加反応そのものは進行するものの、望みとは異なる官能基選択性で反応が進行することが明らかとなった。置換基の導入、官能基の変換を行うことで選択性を制御すべく、必要となる基質の設計および合成を行った。リコポジウムアルカロイドの合成研究:ピログルタミン酸を原料として用い、カルボン酸部位の還元と保護、二重結合の導入を行い、不飽和ラクタムへと変換した。有機銅試薬の1,4-付加反応はラクタム環上の置換基を避ける側から進行した。さらにカルボニル基アルファ位へのアシル基の導入後、ジカルボニル化合物のアクロレインへの付加反応を行ったところ、1,4-付加反応で導入したアルキル側鎖を避ける側から選択的に反応が進行し、ラクタム環上に、第四級炭素を含む連続する3つの不斉中心の構築を行うことができた。
    多官能性縮環天然物の合成に向けて、有用な知見を得ている。
    得られた有用な知見を更に発展させ、また明らかとなった問題点を解決する方法を検討し、研究を推進させる。

  4. 多環式含窒素コア骨格と大環状構造を特徴とする海洋性中分子の合成研究

    Grant number:16H01141  2016.4 - 2018.3

    新学術領域研究(研究領域提案型)

    横島 聡

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    Authorship:Principal investigator 

    Grant amount:\5720000 ( Direct Cost: \4400000 、 Indirect Cost:\1320000 )

    韓国近海のホヤより単離・構造決定されたハリクロニンAの合成研究を行った。昨年度までに合成法を確立していたビシクロ骨格を含む化合物を出発物質とした検討を行っていたが、さらなる官能基変換が困難であることが明らかとなった。そこでビシクロ骨格構築の前に、あらかじめ官能基変換を行う合成経路の検討を行った。その結果、ビシクロ骨格およびその後の変換に必要な官能基をもつ化合物を得ることに成功した。また上記の検討と並行して、酸化的脱芳香環化に続く分子内環化付加反応を基軸とした合成経路について検討を行った。フェノール性水酸基を足がかりとしてベンゼン環上に必要な置換基を導入し、分子内環化付加反応の前駆体を合成した。酸化的脱芳香環化は通常用いられる条件にて円滑に進行し、さらに加熱を行うことで分子内環化付加反応が進行することが明らかとなった。その結果、第四級炭素およびその後の変換に必要となる官能基を含む部分骨格の構築に成功した。デンサニンBの合成研究については以下に述べる知見を得るに至った。不斉ディールスアルダー反応、ジブロモシクロプロパンの開裂による環拡大反応、2-ニトロベンゼンスルホンアミド部位の分子内置換反応を用いて構築した二環性骨格の立体的特性を利用した官能基の選択的な導入について検討を行った。その結果、エノンに対する共役付加が架橋鎖を避ける側から立体選択的に進行することを見出し、第四級炭素の構築に成功した。
    29年度が最終年度であるため、記入しない。
    29年度が最終年度であるため、記入しない。

 

Teaching Experience (On-campus) 8

  1. 基盤創薬学概論

    2020

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    基盤創薬学専攻が目指す人材育成に向け、その導入部分として広く有機化学、生物科学、分子構造学などの関連学問を習得する。加えて、専門科目履修への基礎能力を涵養する。

  2. 化学基礎II

    2020

  3. 化学基礎II

    2019

  4. 基盤創薬学概論

    2019

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    基盤創薬学専攻が目指す人材育成に向け、その導入部分として広く有機化学、生物科学、分子構造学などの関連学問を習得する。加えて、専門科目履修への基礎能力を涵養する。

  5. 農学セミナー

    2019

  6. 生理活性物質化学

    2019

  7. 先端有機化学

    2019

  8. 創薬精密科学

    2019

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