研究者詳細 - 阿部　秀樹

論文 - 阿部　秀樹

分割表示 >> ／全件表示 40 件中 1 - 40 件目

An Almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an olfactory chemoattractant for the grass puffer 査読有り

Noguchi, Y., Suzuki, T., Matsutani, K., Sakakibara, R., Nakahigashi, R., Adachi, M., Nishikawa, T., & Abe, H.

Scientific Reports 12 巻頁： 15087 2022年9月

Green spotted puffer can detect an almost nontoxic TTX analog odor using crypt olfactory sensory neurons. 査読有り

Suzuki, T., Nakahigashi, R., Adachi, M., Nishikawa, T., & Abe, H.

Chemical Senses 47 巻 2022年5月

The odor of a nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, is detected by specific olfactory sensory neurons of the green spotted puffers 査読有り

Suzuki, T., Nakahigashi, R., Adachi, M., Nishikawa, T., & Abe, H.

Chemical Senses 49 巻頁： brae021 2024年5月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Toxic puffers accumulate tetrodotoxin (TTX), a well-known neurotoxin, by feeding on TTX-bearing organisms and using it to defend themselves from predators. Our previous studies have demonstrated that toxic puffers are attracted to 5,6,11-trideoxytetrodotoxin (TDT), a nontoxic TTX analog that is simultaneously accumulated with TTX in toxic puffers and their prey. In addition, activity labeling using immunohistochemistry targeting neuronal activity marker suggests that TDT activates crypt olfactory sensory neurons (OSN) of the green spotted puffer. However, it remains to be determined whether individual crypt OSNs can physiologically respond to TDT and whether TDT is processed differently from other odors in the brain. By employing electroporation to express GCaMP6s in OSNs, we successfully identified a distinct group of oval OSNs that exhibited a specific calcium response when exposed to TDT in green spotted puffers. These oval OSNs showed no response to amino acids (AAs), which serve as food odor cues for teleosts. Furthermore, immunohistochemistry targeting neural activity markers revealed that TDT and AAs odors activate extensively overlapping areas in the dorsomedial olfactory bulb. These results suggest that while different types of OSNs detect TDT and AAs in the olfactory epithelium, these substances are processed as similar odors in the olfactory bulb. The TDT odor may act as a chemoattractant for finding conspecific toxic puffers and for feeding TTX-bearing organisms for effective toxification.

DOI： 10.1101/2023.08.22.552781

DOI： 10.1093/chemse/bjae021

無毒のフグ毒類縁体がフグを誘引する―フグの毒化機構やフグ毒の生物学的意義の研究に新たな展開― 招待有り査読有り

西川俊夫・安立昌篤・阿部秀樹

化学と生物 62 巻頁： 64 - 66 2024年2月

Electric organ discharge from electric eel facilitates DNA transformation into teleost larvae in laboratory conditions 査読有り

Sakaki S, Ito R, Abe H, Kinoshita M, Hondo E, Iida A.

PeerJ 11 巻頁： e16596 2023年12月

フグは無毒のフグ毒の「匂い」を嗅ぐことができる，小特集　香り物質と生き物の最新研究招待有り査読有り

阿部秀樹・鈴木偉久・安立昌篤・西川俊夫

24 巻頁： 38 - 45 2023年2月

Gene disruption of medaka (Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2) causes movement retardation 査読有り国際誌

Watanabe Yuko, Okuya Kazuho, Takada Yuki, Kinoshita Masato, Yokoi Saori, Chisada Shinichi, Kamei Yasuhiro, Tatsukawa Hideki, Yamamoto Naoyuki, Abe Hideki, Hashimoto Hisashi, Hitomi Kiyotaka

JOURNAL OF BIOCHEMISTRY 168 巻 ( 3 ) 頁： 213 - 222 2020年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Transglutaminases (TGases) are an enzyme family that catalyzes protein cross-linking essential for several biological functions. In the previous studies, we characterized the orthologues of the mammalian TGase family in medaka (Oryzias latipes), an established fish model. Among the human isozymes, tissue-type transglutaminase (TG2) has multiple functions that are involved in several biological phenomena. In this study, we established medaka mutants deficient for the orthologue of human TG2 (OlTGT) using the CRISPR/Cas9 and TALEN systems. Although apparent morphological changes in the phenotype were not observed, movement retardation was found in the mutant fish when evaluated by a tank diving test. Furthermore, comparative immunohistochemistry analysis using in this fish model revealed that OlTGT was expressed at the periventricular layer of the optic tectum. Our findings provide novel insight for the relationship between tissue-type TGase and the nervous system and the associated behavior.

DOI： 10.1093/jb/mvaa038

Web of Science

PubMed

researchmap

Afferent and efferent connections of the nucleus prethalamicus in the yellowfin goby Acanthogobius flavimanus 査読有り国際誌

Hagio Hanako, Kawaguchi Masahumi, Abe Hideki, Yamamoto Naoyuki

JOURNAL OF COMPARATIVE NEUROLOGY 529 巻 ( 1 ) 頁： 87 - 110 2020年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

The nucleus prethalamicus (PTh) receives fibers from the optic tectum and then projects to the dorsal telencephalon in the yellowfin goby Acanthogobius flavimanus. However, it remained unclear whether the PTh is a visual relay nucleus, because the optic tectum receives not only visual but also other sensory modalities. Furthermore, precise telencephalic regions receiving prethalamic input remained unknown in the goby. We therefore investigated the full set of afferent and efferent connections of the PTh by direct tracer injections into the nucleus. Injections into the PTh labeled cells in the optic tectum, ventromedial thalamic nucleus, central and medial parts of the dorsal telencephalon, and caudal lobe of the cerebellum. We found that the somata of most tecto-prethalamic neurons are present in the stratum periventriculare. Their dendrites ascend to reach the major retinorecipient layers of the tectum. The PTh is composed of two subnuclei (medial and lateral) and topographic organization was appreciated only for tectal projections to the lateral subnucleus (PTh-l), which also receives sparse retinal projections. In contrast, the medial subnucleus receives fibers only from the medial tectum. We found that the PTh projects to nine subregions in the dorsal telencephalon and four in the ventral telencephalon. Furthermore, cerebellar injections revealed that cerebello-prethalamic fibers cross the midline twice to innervate the PTh-l on both sides. The present study is the first detailed report on the full set of the connections of PTh, which suggests that the PTh relays visual information from the optic tectum to the telencephalon. This article is protected by copyright. All rights reserved.

DOI： 10.1002/cne.24935

Web of Science

PubMed

researchmap

Indirect pathway to pectoral fin motor neurons from nucleus ruber in the Nile tilapia Oreochromis niloticus 査読有り

Nakayama Tomoya, Nishino Hirotaka, Narita Junya, Abe Hideki, Yamamoto Naoyuki

JOURNAL OF COMPARATIVE NEUROLOGY 527 巻 ( 5 ) 頁： 957-971 2019年4月

Nucleus Ruber of Actinopterygians. 査読有り

Nakayama T, Miyajima S, Nishino H, Narita J, Abe H, Yamamoto N

Brain, behavior and evolution 88 巻 ( 1 ) 頁： 25-42 2016年

GnRH suppresses excitability of visual processing neurons in the optic tectum. 査読有り

Umatani C, Misu R, Oishi S, Yamaguchi K, Abe H, Oka Y

Journal of neurophysiology 114 巻 ( 5 ) 頁： 2775-2784 2015年11月

Morphological analysis of the early development of telencephalic and diencephalic gonadotropin-releasing hormone neuronal systems in the enhanced green fluorescent protein-expressing transgenic medaka lines 査読有り

Takahashi, A., Islam, S.M., Abe, H., Okubo, K., Akazome, Y., Kaneko, T., Hioki, H., Oka, Y.

J. Comp. Neurol. 頁： 0000 2015年8月

Connections of the commissural nucleus of Cajal in the goldfish with special reference to the topographic organization of ascending visceral sensory pathways, 査読有り

Uezono S., Yamada Y., Kato T., Abe H., Yamamoto N.

J. Comp. Neurol. 523 巻 ( 2 ) 頁： 209-225 2015年2月

Kiss1 Neurons Drastically Change Their Firing Activity in Accordance With the Reproductive State: Insights From a Seasonal Breeder 査読有り

Hasebe M., Kanda S., Shimada H., Akazome Y., Abe H., Oka Y.

Endocrinology 155 巻 ( 12 ) 頁： 4868-4880 2014年12月

Intrinsic photosensitivity of deep brain photoreceptor 査読有り

Nakane Y., Shimmura T., Abe H., Yoshimura T.

Current Biology 24 巻頁： R596-597 2014年7月

Whole brain-pituitary in vitro preparation of the transgenic medaka (Oryzias latipes) as a tool for analyzing the differential regulatory mechanisms of LH and FSH release 査読有り

Karigo, T., Aikawa, M., Kondo, C., Abe, H., Kanda, S., Oka, Y.

Endocrinology 155 巻頁： 536-547 2014年2月

A Neural Mechanism Underlying Mating Preferences for Familiar Individuals in Medaka Fish 査読有り

Okuyama, T., Yokoi, S., Abe, H., Isoe, Y., Suehiro, Y., Imada, H., Tanaka, M., Kawasaki, T., Yuba, S., Taniguchi, Y., Kamei, Y., Okubo, K., Shimada, A., Natuse, K., Takeda, H., Oka, Y., Kubo, T., and Takeuchi, H.

Science 343 巻 ( 6 ) 頁： 91-94 2014年1月

Burst generation mediated by cholinergic input in terminal nerve-gonadotrophin releasing hormone neurones of the goldfish 査読有り

Kawai T., Abe H., Oka Y.

J. Physiol. 591 巻頁： 5509-5523 2013年11月

The saccus vasculosus of fish is a sensor of seasonal changes in day length 査読有り

Nakane, Y., Ikegami, K., Iigo, M., Ono, H., Takeda, K., Takahashi, D., Uesaka, M., Kimijima, M., Hashimoto, R., Arai, N., Suga, T., Kosuge, K., Abe, T., Maeda, R., Senga, T., Amiya, N., Azuma, T., Amano, M., Abe, H., Yamamoto, N. & Yoshimura, T.

Nature Communications 4 巻頁： 2108 2013年7月

Neuropeptide RFRP inhibits the pacemaker activity of terminal nerve GnRH neurons 査読有り

Umatani, C., Abe, H., Oka, Y.

J. Neurophysiol. 109 巻頁： 2354-2363 2013年5月

Time-of-Day-dependent changes in GnRH1 neuronal activities and gonadotropin mRNA expression in a daily spawning fish, medaka. 査読有り

Karigo, T., Kanda, S., Takahashi, A., Abe, H., Okubo, K., Oka, Y.

Endocrinology 153 巻 ( 7 ) 頁： 3394-3404 2012年7月

Dopaminergic neuromodulation of synaptic transmission between the mitral and granule cells in the teleost olfactory bulb. 査読有り

Kawai, T., Abe, H., and Oka, Y.

J. Neurophysiol. 107 巻頁： 1313-1324 2012年

Mechanisms of neuromodulation by a non-hypophysiotropic GnRH system controlling motivation of reproductive behavior in the teleost brain. 招待有り査読有り

Abe, H. and Oka, Y.

Journal of Reproduction and Development. 57 巻 ( 6 ) 頁： 665-674 2011年

Regular pacemaker activity characterizes gonadotropin-releasing hormone 2 neurons recorded from green fluorescent protein-transgenic medaka 査読有り

Kanda, S., Nishikawa, K., Karigo, T., Okubo, K., Isomae, S., Abe, H., Kobayashi, D., and Oka, Y.

Endocrinology 151 巻頁： 695-701 2010年

Neuromodulatory effect of GnRH on the synaptic transmission of the olfactory bulbar neural circuit in goldfish, Carassius auratus 査読有り

Kawai, T., Abe, H., Akazome, Y., and Oka, Y.

J. Neurophysiol 104 巻頁： 3540-3550 2010年

Electrophysiological analysis of the inhibitory effects of FMRFamide-like peptides on the pacemaker activity of gonadotropin-releasing hormone neurons. 査読有り

Saito, T.H., Nakane, R., Akazome, Y., Abe, H., and Oka, Y.

J. Neurophysiol. 104 巻頁： 3518-3529 2010年

Primary culture of the isolated terminal nerve - gonadotrophin-releasing hormone neurones derived from adult teleost (dwarf gourami, Colisa lalia) brain for the study of peptide release mechanisms. 査読有り

Abe, H. and Oka, Y.

J. Neuroendocrinol. 21 巻頁： 489 - 505 2009年

Calcium oscillations in the olfactory nonsensory cells of the goldfish, Carassius auratus. 査読有り

Kawai, T., Abe, H., Wakabayashi, K., and Oka, Y.

Biochimica et Biophysica Acta 1790 巻頁： 1681-1688 2009年

Mechanism of rapid action of estrogen in LHRH neurons: A possible role of G-protein coupled receptor 30 in GT1-7 cells. 査読有り国際共著

Noel, S.D., Keen, K.L., Abe, H., Frost, S.I., Filado, E.J., Terasawa, E.

Front. Neuroendcrinol 27 巻頁： 70 - 71 2008年

Rapid action of estrogen on intracellular calcium oscillations in primate LHRH-1 neurons. 査読有り国際共著

Abe, H., Keen, K.L. and Terasawa, E

Endocrinology 149 巻頁： 1155 - 1162 2008年

Neuromodulatory functions of terminal nerve-GnRH neurons. 招待有り査読有り

Abe, H. and Oka, Y.

Fish Physiology Vol. 25, Sensory Systems Neuroscience 頁： 455-503 2007年

Firing Pattern and Rapid Modulation of Activity by Estrogen in Primate LHRH-1 Neurons. 査読有り国際共著

Abe, H. and Terasawa, E.

Endocrinology 146 巻頁： 4312 - 4320 2005年

Ligand-induced dynamic rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptor 1α. 査読有り

Tateyama, M., Abe, H., Nakata, H., Saito, O. and Kubo, Y

Nature Structural & Molecular Biology 11 巻頁： 637 - 642 2004年

Distribution of Regulator of G protein signaling 8 (RGS8) protein in the cerebellum. 査読有り

Saitoh, O., Masuho, I., Itoh, M., Abe, H., Komori, K. and Odagiri, M.

The CEREBELLUM 2 巻頁： 154 - 160 2003年

Functional identification of Gd3+ binding site of metabotropic glutamate receptor 1α. 査読有り

Abe, H., Tateyama, M. and Kubo, Y.

FEBS letter 27356 巻頁： 1 - 6 2003年

Effects of co-expression with Homer isoforms on the function of metabotropic glutamate receptor 1α. 査読有り

Abe, H., Misaka, T., Tateyama, M. and Kubo, Y.

Mol. Cell. Neurosci. 23 巻頁： 157 - 168 2003年

Mechanisms of the modulation of pacemaker activity by GnRH peptides in the terminal nerve-GnRH neurons 査読有り

Abe, H. and Oka, Y.

Zool. Sci. 19 巻頁： 111 - 128 2002年

RGS8 protein is distributed in dendrites and cell body of cerebellar Purkinje cell. 査読有り

Itoh, M., Odagiri, M., Abe, H. and Saitoh, O.

Biochem. Biophys. Res. Commun. 287 巻頁： 223 - 228 2001年

Modulation of pacemaker activity by salmon gonadotropin-releasing hormone (sGnRH) in terminal nerve (TN)-GnRH neurons 査読有り

Abe, H. and Oka, Y.

J. Neurophysiol. 83 巻頁： 3196 - 3200 2000年

Characterization of K+ currents underlying pacemaker potentials of fish gonadotropin-releasing hormone cells. 査読有り

Abe, H. and Oka, Y.

J. Neurophysiol. 81 巻頁： 643 - 653 1999年

　前のページ - 次のページ　

<阿部 秀樹>

論文 - 阿部 秀樹

<阿部　秀樹>

論文 - 阿部　秀樹