Updated on 2022/03/23

写真a

 
OKUMURA Takahiro
 
Organization
Nagoya University Hospital Center Lecturer of hospital
Title
Lecturer of hospital
Contact information
メールアドレス

Degree 1

  1. 博士(医学) ( 2012.3   名古屋大学 ) 

Research Interests 3

  1. 心筋炎

  2. 心筋症

  3. 心不全

Research Areas 1

  1. Life Science / Cardiology  / heart failure; cardiomyopathy; myocarditis

Current Research Project and SDGs 73

  1. 心不全の発症・重症化の高精度予測とそれに基づく最適な治療法の開発のための心不全レジストリ

  2. 心不全における急性期薬物治療の実態と予後に関する多施設共同前向き観察研究(POPEYE-AHF)

  3. 急性心不全急性期治療と予後との関係性に関する多施設レジストリ研究

  4. 劇症型心筋炎レジストリ構築のための基盤調査研究(CHANGE-PUMP)

  5. 心臓カヘキシ―における心腸肝連関の解析と評価のための新規マーカーの探索

  6. 心筋疾患におけるマイオカインの病態生理学的意義解明と治療応用のための基盤研究

  7. 心室細動の病理所見~非虚血性心臓性突然死剖検例の病理組織学的検討

  8. 拡張型心筋症における運動時周期性呼吸変動のメカニズムと予後

  9. Duchenne型筋ジストロフィ心筋症とβ遮断薬早期導入の有用性

  10. Multicenter Observational Prospective Study of Biopsy-proven Acute Myocarditis (MERCURY)

  11. 拡張型心筋症におけるカテプシンKの病態生理学意義解明と新規治療への応用

  12. 日本における補助人工心臓に関連した市販後のデータ収集 (J-MACS)

  13. 代謝性心筋リモデリングにおけるメタボローム解析

  14. 心不全Frailtyの予後予測妥当性と心臓リハビリテーション効果に関する研究

  15. 次世代シーケンサーを用いた重症感染症の原因微生物の網羅的解析

  16. 高齢心不全患者の予後規定因子に関する調査研究

  17. わが国における拡張相肥大型心筋症を対象とした登録観察研究

  18. 遺伝性心血管疾患の感受性遺伝子解析研究

  19. 左室収縮機能の維持された心不全の治療薬探索に関する多施設共同登録・観察研究

  20. 名古屋大学関連病院及び愛知県主要病院における冠動脈形成術の実態調査と予後の観察研究

  21. 慢性心不全に合併したうつ病と運動介入についての研究

  22. 拡張能障害によるうっ血性心不全の予後予測因子の検討および治療戦略 (MEIDAI-HF registry)

  23. 特発性心筋症における病態進行予測のための観察研究

  24. 拡張型心筋症患者におけるジストロフィン糖蛋白質複合体の発現に関する研究

  25. 肥大型心筋症における微小循環不全と血管新生促進・抑制機構のメカニズム解明研究

  26. 植込型補助人工心臓装着患者に対するICTを活用した多職種連携在宅治療サポートシステムの構築に関する研究

  27. 重症心不全の診療実態調査

  28. 心不全における当院の事前指示書の有効性評価

  29. 急性心筋炎における原因ウイルス及び免疫系の影響に関する探索的研究

  30. 補助循環用ポンプカテーテルに関するレジストリ事業 (J-PVAD)

  31. Anderson-Fabry病における心筋障害および予後に関するチャートレビュー

  32. 認定植込型補助人工心臓実施施設における劇症型心筋炎治療の実態調査

  33. 心筋症患者における心筋病理指標の病期評価能を検証する多施設前向き観察研究

  34. ハートシートを使用した患者に関する再生医療等製品患者登録システムによる市販後研究

  35. 心筋生検にて診断された急性心筋炎の多施設共同前向き観察研究

  36. 心臓サルコイドーシスにおける多施設後向きレジストリ―研究

  37. アミロイドーシスの予後予測に関する後ろ向きカルテ調査

  38. 循環器領域ファブリー病患者診断ストラテジー構築のための後ろ向き解析研究

  39. 繰返し入院する慢性心不全患者を対象としたASV療法の予後に関する前向きコホート研究: 再入院や死亡に関する影響を検討する縦断的観察研究

  40. がん化学療法関連心血管合併症のチャートレビュー

  41. 急性心不全の予後予測に関する多施設後ろ向き観察研究

  42. 免疫チェックポイント阻害薬誘発性潜在的心筋障害モニタリングのための登録研究

  43. 急性非代償性心不全の実態に関する多施設観察研究

  44. 冠動脈疾患患者における病態進行ならびに長期予後予測のための観察研究

  45. 循環器疾患及びリスク因子合併COVID-19入院患者に関する多施設共同観察研究:CLAVIS-COVID

  46. 左室駆出率の保たれた心不全に合併した持続性心房細動における、カテーテルアブレーションの効果の前向き観察研究

  47. 心移植待機中のLVAD装着術後患者における身体機能に関する調査

  48. 心内膜心筋生検組織を用い拡張型心筋症における炎症細胞浸潤の意義を検討する多施設レジストリ研究-2

  49. 免疫チェックポイント阻害薬使用に伴う心筋障害に対する全国多施設共同レジストリ

  50. SGLT2阻害薬トホグリフロジンを用いた心保護効果のメカニズムに関する研究

  51. 中性脂肪蓄積心筋血管症の診断法の確立

  52. 拡張機能低下型心不全に対するニフェジピンCRの有効性の検討 (DEMAND試験)

  53. 難治性の心不全患者に対するトルバプタン継続投与のQOLに対する有用性を検討する探索的ランダム化、非盲検、並行群間比較試験(AQUA-TLV)

  54. 収縮能が保持された心不全(Heart Failure with Preserved Ejection Fraction: HFPEF)患者を対象としたトルバプタンの短期および長期投与の有用性の検討 多施設共同、ランダム化、非盲検試験

  55. 高尿酸血症を合併する慢性心不全患者を対象とした尿酸降下薬フェブキソスタットの効果に関する多施設共同ランダム化比較試験

  56. ドライバー体調アシストシステムの開発に向けた心疾患患者のストレス時生体信号モニタリング調査

  57. 慢性心不全合併糖尿病患者におけるカナグリフロジンの安全性評価試験-ランダム化非劣性試験-CANDLE試験

  58. SGLT2阻害薬による動脈硬化予防の多施設共同ランダム化比較試験 (PROTECT試験)

  59. 拡張型および肥大型心筋症における心予備能の評価と心筋病理組織および心筋mRNA発現量の検討

  60. 心不全患者におけるAST-120の心機能改善効果の検討に関する臨床試験

  61. 慢性心不全患者を対象としたAdaptive-Servo Ventilatorに関するランダム化比較試験

  62. 心臓サルコイドーシスにおけるFDG-PETガイド下治療介入研究

  63. 拡張型心筋症に対するテイラーメイド方式心臓形状矯正ネットの臨床試験

  64. 回復期遠隔心臓リハビリテーションの効果に関する研究

  65. 心不全増悪入院患者におけるアンジオテンシン・ネプリライシン阻害薬の研究

  66. 加齢関連線維性疾患に対する新規バイオマーカーの後方視的観察研究

  67. 機械的補助循環を要する重症心不全患者の心臓リハビリテーションに関する研究

  68. 腎性貧血合併心不全患者におけるHIF-PH阻害薬に関する研究

  69. オールジャパンで行う全身性アミロイドーシスコホート研究

  70. 心房中隔欠損患者における経カテーテル閉鎖術前後での運動耐容能変化と心エコー所見に関する後向き検討

  71. 慢性腎臓病を合併した慢性心不全患者の外来での腎機能と電解質の多施設共同後ろ向き観察研究

  72. 心筋病理により診断されたCOVID-19ワクチン関連心筋炎の多施設共同後ろ向き研究

  73. 左室収縮能が軽度低下もしくは保たれた⾼齢⼊院⼼不全患者におけるトランスサイレチン型⼼アミロイドーシスの有病率と臨床的意義を検討する前向き多施設研究

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Research History 8

  1. Nagoya University   Lecturer of hospital

    2016.11

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    Country:Japan

  2. Nagoya University   Innovative Research Center for Preventive Medical Engineering   Assistant Professor

    2014.1 - 2016.10

  3. 名古屋大学医学部附属病院   循環器内科   病院助教

    2012.4 - 2016.10

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    Country:Japan

  4. 大阪大学医学部附属病院   循環器内科   医員

    2011.5 - 2012.3

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    Country:Japan

  5. 名古屋大学大学院医学系研究科   循環器内科学   大学院生

    2008.4 - 2012.3

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    Country:Japan

  6. 西尾市民病院   内科(循環器)   医員

    2007.8 - 2008.3

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    Country:Japan

  7. 名古屋掖済会病院   循環器科   医員

    2003.4 - 2007.7

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    Country:Japan

  8. 名古屋掖済会病院   初期研修医

    2001.4 - 2003.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medicine

    - 2012.3

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    Country: Japan

  2. Nagoya City University   Faculty of Medicine

    - 2000.3

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    Country: Japan

Professional Memberships 19

  1. 日本内科学会   東海支部評議員

  2. 日本循環器学会   Fellow of JCS, 東海支部評議員

  3. 日本心不全学会   代議員

  4. 日本腫瘍循環器学会   評議員

  5. 日本心臓リハビリテーション学会   評議員

  6. 心筋生検研究会   幹事、学術企画委員会(委員)

  7. 日本心臓病学会

  8. 日本救急医学会

  9. 日本心血管インターベンション学会

  10. 日本不整脈学会

  11. 日本移植学会

  12. 日本抗加齢医学会

  13. 日本肺高血圧・肺循環学会

  14. 日本サルコペニアフレイル学会

  15. American Heart Association

  16. European Society of Cardiology   Fellow of ESC

  17. 日本医療の質・安全学会

  18. 日本循環器協会   評議員

  19. 日本糖尿病協会

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Committee Memberships 17

  1. 日本心不全学会 教育・ガイドライン委員会   幹事  

    2012.4 - 2014.3   

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    Committee type:Academic society

  2. 心筋生検研究会 学術企画委員会   委員  

    2014.4   

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    Committee type:Academic society

  3. 日本心不全学会 教育研修委員会   幹事  

    2014.4   

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    Committee type:Academic society

  4. 日本心不全学会 チーム医療推進委員会   委員  

    2017.4   

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    Committee type:Academic society

  5. 日本心不全学会 在り方委員会   委員  

    2017.4   

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    Committee type:Academic society

  6. 日本循環器学会 重症心不全に対する植込み型補助人工心臓治療ガイドライン(2020 年改訂版)作成班   協力員  

    2019 - 2020   

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    Committee type:Academic society

  7. 日本心臓リハビリテーション学会 卒前・卒後教育対策部会   委員  

    2019.1   

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    Committee type:Academic society

  8. 日本腫瘍循環器学会 利益相反委員会   委員  

    2019.4   

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    Committee type:Academic society

  9. 日本循環器学会 予防・国民への啓発サブワーキンググループ   委員  

    2020   

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    Committee type:Academic society

  10. 日本循環器学会 心不全療養指導士実務部会   委員  

    2020   

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    Committee type:Academic society

  11. 日本循環器学会 急性および慢性心筋炎の診断・治療に関するガイドライン(2023 年改訂版)作成班   班員  

    2021   

  12. 日本循環器学会 理念検討ワーキンググループ   委員  

    2021 - 2022   

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    Committee type:Academic society

  13. 厚生労働省 難治性疾患政策研究事業 中性脂肪蓄積心筋血管症研究班 心筋生検委員会   委員  

    2020   

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    Committee type:Academic society

  14. 日本循環器学会 総務委員会   協力員  

    2020   

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    Committee type:Academic society

  15. 厚生労働省 難治性疾患政策研究事業 中性脂肪蓄積心筋血管症研究班 ホームページ委員会   委員  

    2020   

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    Committee type:Academic society

  16. 日本循環器学会 脳卒中と循環器病克服5ヵ年計画作成ワーキンググループ   委員  

    2020 - 2021   

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    Committee type:Academic society

  17. 日本臨床腫瘍学会 OncoCardiology ガイダンス作成 WG   協力員  

    2019   

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    Committee type:Academic society

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Awards 5

  1. 日本循環器学会 第156回東海・第141回北陸合同地方会 最優秀演題賞

    2020.10   日本循環器学会  

  2. Circulation Journal Best Reviewer Award 2019

    2019.12   Circulation Journal  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  3. Circulation Journal Best Reviewer Award 2018

    2018.12   Circulation Journal  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  4. 第10回日本心臓リハビリテーション学会Young Investigator Award最優秀賞

    2013.7   日本心臓リハビリテーション学会  

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    Country:Japan

  5. 第14回日本心不全学会学術集会 Young Investigator Award 最優秀賞(臨床)

    2010.10   日本心不全学会  

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    Country:Japan

 

Papers 130

  1. Bedside cannulation for veno-venous extracorporeal membrane oxygenation using portable X-ray system in a coronavirus disease patient. Reviewed

    Kondo T, Kuwayama T, Hiraiwa H, Kasugai D, Goto Y, Numaguchi A, Katsu T, Matsui T, Hashimoto N, Tanaka A, Morimoto R, Okumura T, Murohara T

    Journal of cardiology cases   Vol. 25 ( 3 ) page: 185 - 187   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2021.09.008

    PubMed

  2. Clinical value of the HATCH score for predicting adverse outcomes in patients with heart failure Reviewed

    Shibata Naoki, Kondo Toru, Morimoto Ryota, Kazama Shingo, Sawamura Akinori, Nishiyama Itsumure, Kato Toshiaki, Kuwayama Tasuku, Hiraiwa Hiroaki, Umemoto Norio, Asai Toru, Okumura Takahiro, Murohara Toyoaki

    HEART AND VESSELS     2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00380-022-02035-w

    Web of Science

    PubMed

  3. Differences in Prognosis and Cardiac Function According to Required Percutaneous Mechanical Circulatory Support and Histological Findings in Patients With Fulminant Myocarditis: Insights From the CHANGE PUMP 2 Study Reviewed

    Kondo Toru, Okumura Takahiro, Shibata Naoki, Imaizumi Takahiro, Dohi Kaoru, Izawa Hideo, Ohte Nobuyuki, Amano Tetsuya, Murohara Toyoaki

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 11 ( 4 ) page: e023719   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.121.023719

    Web of Science

    PubMed

  4. Biopsy-proven Fulminant Myocarditis Requiring Mechanical Circulatory Support Following COVID-19 mRNA Vaccination. Reviewed

    Kazama S, Okumura T, Kimura Y, Ito R, Araki T, Mizutani T, Oishi H, Kuwayama T, Hiraiwa H, Kondo T, Morimoto R, Saeki T, Murohara T

    CJC open     2022.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cjco.2022.02.004

    PubMed

  5. Relationship between spleen size and exercise tolerance in advanced heart failure patients with a left ventricular assist device Reviewed

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Araki Takashi, Mizutani Takashi, Kazama Shingo, Kimura Yuki, Shibata Naoki, Oishi Hideo, Kuwayama Tasuku, Kondo Toru, Furusawa Kenji, Morimoto Ryota, Adachi Takuji, Yamada Sumio, Mutsuga Masato, Usui Akihiko, Murohara Toyoaki

    BMC RESEARCH NOTES   Vol. 15 ( 1 ) page: 40   2022.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13104-022-05939-y

    Web of Science

    PubMed

  6. Clinical implication of initial intravenous diuretic dose for acute decompensated heart failure Reviewed

    Yoshioka Kenji, Maeda Daichi, Okumura Takahiro, Kida Keisuke, Oishi Shogo, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Mizukami Akira, Kuroda Shunsuke, Kagiyama Nobuyuki, Yamaguchi Tetsuo, Sasano Tetsuo, Matsumura Akihiko, Kitai Takeshi, Matsue Yuya

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 2127   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-06032-x

    Web of Science

    PubMed

  7. Effect of carperitide on the 1 year prognosis of patients with acute decompensated heart failure Reviewed

    Nogi Kazutaka, Ueda Tomoya, Matsue Yuya, Nogi Maki, Ishihara Satomi, Nakada Yasuki, Kawakami Rika, Kagiyama Nobuyuki, Kitai Takeshi, Oishi Shogo, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Kida Keisuke, Okumura Takahiro, Saito Yoshihiko

    ESC HEART FAILURE     2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ehf2.13770

    Web of Science

    PubMed

  8. Methods for confirming the safety of radiation therapy in patients with left ventricular assist device: a case of extranodal NK/T-cell lymphoma, nasal type Reviewed

    Oishi Hideo, Kondo Toru, Kawamura Mariko, Shimada Kazuyuki, Mutsuga Masato, Kurokawa Takashi, Kuwayama Tasuku, Hiraiwa Hiroaki, Morimoto Ryota, Okumura Takahiro, Nishida Tetsuya, Kiyoi Hitoshi, Naganawa Shinji, Usui Akihiko, Murohara Toyoaki

    JOURNAL OF ARTIFICIAL ORGANS     2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10047-022-01312-9

    Web of Science

    PubMed

  9. Serum autotaxin as a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy Reviewed

    Araki Takashi, Okumura Takahiro, Hiraiwa Hiroaki, Mizutani Takashi, Kimura Yuki, Kazama Shingo, Shibata Naoki, Oishi Hideo, Kuwayama Tasuku, Kondo Toru, Morimoto Ryota, Takefuji Mikito, Murohara Toyoaki

    ESC HEART FAILURE     2022.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ehf2.13817

    Web of Science

    PubMed

  10. Splenic size as an indicator of hemodynamics and prognosis in patients with heart failure Reviewed

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Araki Takashi, Mizutani Takashi, Kazama Shingo, Kimura Yuki, Shibata Naoki, Oishi Hideo, Kuwayama Tasuku, Kondo Toru, Furusawa Kenji, Morimoto Ryota, Murohara Toyoaki

    HEART AND VESSELS     2022.1

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    DOI: 10.1007/s00380-022-02030-1

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  11. Clinical Effect of Pulmonary Artery Diameter/Ascending Aorta Diameter Ratio on Left Ventricular Reverse Remodeling in Patients With Dilated Cardiomyopathy. Reviewed

    Shibata N, Hiraiwa H, Kazama S, Kimura Y, Araki T, Mizutani T, Oishi H, Kuwayama T, Kondo T, Morimoto R, Okumura T, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society     2022.1

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    DOI: 10.1253/circj.CJ-21-0786

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  12. Flexion limitation of the Impella 5.0 when implanted using the femoral approach in patients with small stature Reviewed

    Hiraiwa Hiroaki, Kimura Yuki, Morimoto Ryota, Ito Ryota, Araki Takashi, Mizutani Takashi, Kazama Shingo, Oishi Hideo, Kuwayama Tasuku, Kondo Toru, Furusawa Kenji, Okumura Takahiro, Mutsuga Masato, Usui Akihiko, Murohara Toyoaki

    JOURNAL OF ARTIFICIAL ORGANS     2022.1

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    DOI: 10.1007/s10047-022-01311-w

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  13. Impella5.0 "ILIPELLA" Approach for a Fulminant Myocarditis Patient With a Small Peripheral Artery. Reviewed

    Mutsuga M, Banno H, Okumura T, Morimoto R, Kondo T, Kimura Y, Hiraiwa H, Murohara T, Usui A

    Heart, lung & circulation     2022.1

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    DOI: 10.1016/j.hlc.2021.12.007

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  14. Usefulness of Incorporating Hypochloremia into the Get With The Guidelines-Heart Failure Risk Model in Patients With Acute Heart Failure Reviewed

    Misumi Kayo, Matsue Yuya, Nogi Kazutaka, Sunayama Tsutomu, Dotare Taishi, Maeda Daichi, Kagiyama Nobuyuki, Kasai Takatoshi, Kitai Takeshi, Oishi Shogo, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Kida Keisuke, Okumura Takahiko, Nogi Maki, Ishihara Satomi, Ueda Tomoya, Kawakami Rika, Saito Yoshihiko, Minamino Tohru

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 162   page: 122 - 128   2022.1

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    DOI: 10.1016/j.amjcard.2021.09.020

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  15. Multidisciplinary Approaches for Transthyretin Amyloidosis Reviewed

    Koike Haruki, Okumura Takahiro, Murohara Toyoaki, Katsuno Masahisa

    CARDIOLOGY AND THERAPY   Vol. 10 ( 2 ) page: 289 - 311   2021.12

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    DOI: 10.1007/s40119-021-00222-w

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  16. Prognostic impact of transcardiac gradient of follistatin-like 1 reflecting hemodynamics in patients with dilated cardiomyopathy Reviewed

    Oishi Hideo, Okumura Takahiro, Ohashi Koji, Kimura Yuki, Kazama Shingo, Shibata Naoki, Arao Yoshihito, Kato Hiroo, Kuwayama Tasuku, Yamaguchi Shogo, Tatsumi Minako, Kondo Toru, Hiraiwa Hiroaki, Morimoto Ryota, Takefuji Mikito, Ouchi Noriyuki, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 78 ( 6 ) page: 524 - 532   2021.12

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    DOI: 10.1016/j.jjcc.2021.07.005

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  17. New Vision, Mission, and Values of the Japanese Circulation Society Reviewed

    Ishida Mari, Matsumoto Chisa, Kida Keisuke, Fukuda Memori, Kagiyama Nobuyuki, Kusunose Kenya, Matsumoto Shingo, Nomura Seitaro, Okumura Takahiro, Shiono Yasutsugu, Taniguchi Tatsunori, Mizuno Atsushi, Kishi Takuya, Node Koichi, Komuro Issei, Hirata Ken-ichi

    CIRCULATION JOURNAL   Vol. 85 ( 12 ) page: 2248 - +   2021.12

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    DOI: 10.1253/circj.CJ-21-0822

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  18. LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia Reviewed International coauthorship

    Ishihama Sohta, Yoshida Satoya, Yoshida Tatsuya, Mori Yu, Ouchi Noriyuki, Eguchi Shunsuke, Sakaguchi Teruhiro, Tsuda Takuma, Kato Katsuhiro, Shimizu Yuuki, Ohashi Koji, Okumura Takahiro, Bando Yasuko K., Yagyu Hiroaki, Wettschureck Nina, Kubota Naoto, Offermanns Stefan, Kadowaki Takashi, Murohara Toyoaki, Takefuji Mikito

    FASEB JOURNAL   Vol. 35 ( 12 ) page: e22048   2021.12

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    DOI: 10.1096/fj.202100882R

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  19. Comparison of Impella 5.0 and extracorporeal left ventricular assist device in patients with cardiogenic shock Reviewed

    Kondo Toru, Morimoto Ryota, Mutsuga Masato, Fujimoto Kazuro, Okumura Takahiro, Shibata Naoki, Kazama Shingo, Kimira Yuki, Oishi Hideo, Kuwayama Tasuku, Hiraiwa Hiroaki, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 11 ) page: 846 - 853   2021.11

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    DOI: 10.1177/03913988211040530

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  20. Genetic Deficiency of Adipose Triglyceride Lipase Is Associated With a Novel Type of Podocytopathy Reviewed

    Nagasawa Yasuyuki, Okumura Takahiro, Hara Yasuhiro, Kondo Toru, Hasegawa Midori, Ikeda Yoshihiko, Murohara Toyoaki, Hirano Ken-ichi

    KIDNEY INTERNATIONAL REPORTS   Vol. 6 ( 10 ) page: 2722 - 2725   2021.10

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    DOI: 10.1016/j.ekir.2021.07.013

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  21. Prognostic Implications of Reductions in Heart Rates in Patients With Acute Heart Failure and Atrial Fibrillation Reviewed

    Kida Keisuke, Kitai Takeshi, Suzuki Norio, Ashikaga Kohei, Kou Seisyou, Kagiyama Nobuyuki, Yamaguchi Tetsuo, Okumura Takahiro, Mizuno Atsushi, Oishi Shogo, Inuzuka Yasutaka, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Matsue Yuya

    CIRCULATION JOURNAL   Vol. 85 ( 10 ) page: 1869 - 1875   2021.10

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    DOI: 10.1253/circj.CJ-21-0269

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  22. Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock Reviewed

    Hiraiwa Hiroaki, Kasugai Daisuke, Ozaki Masayuki, Goto Yukari, Jingushi Naruhiro, Higashi Michiko, Nishida Kazuki, Kondo Toru, Furusawa Kenji, Morimoto Ryota, Okumura Takahiro, Matsuda Naoyuki, Matsui Shigeyuki, Murohara Toyoaki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 18823   2021.9

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    DOI: 10.1038/s41598-021-98397-8

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  23. High-output Heart Failure Caused by a Tumor-related Arteriovenous Fistula: A Case Report and Literature Review Reviewed

    Tobe Akihiro, Tanaka Akihito, Yoshida Satoya, Kondo Toru, Morimoto Ryota, Furusawa Kenji, Okumura Takahiro, Bando Yasuko K., Ishii Hideki, Murohara Toyoaki

    INTERNAL MEDICINE   Vol. 60 ( 18 ) page: 2979 - 2984   2021.9

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    DOI: 10.2169/internalmedicine.6962-20

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  24. Effect of canagliflozin on N-terminal pro-brain natriuretic peptide in patients with type 2 diabetes and chronic heart failure according to baseline use of glucose-lowering agents Reviewed

    Tanaka Atsushi, Toyoda Shigeru, Imai Takumi, Shiina Kazuki, Tomiyama Hirofumi, Matsuzawa Yasushi, Okumura Takahiro, Kanzaki Yumiko, Onishi Katsuya, Kiyosue Arihiro, Nishino Masami, Sakata Yasushi, Node Koichi

    CARDIOVASCULAR DIABETOLOGY   Vol. 20 ( 1 ) page: 175   2021.9

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    DOI: 10.1186/s12933-021-01369-5

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  25. Clinical impact of heart rate change in patients with acute heart failure in the early phase Reviewed

    Kazama Shingo, Kondo Toru, Shibata Naoki, Hiraiwa Hiroaki, Nishiyama Itsumure, Kato Toshiaki, Sawamura Akinori, Kimura Yuki, Oishi Hideo, Kuwayama Tasuku, Morimoto Ryota, Okumura Takahiro, Shimizu Kiyokazu, Murohara Toyoaki

    ESC HEART FAILURE   Vol. 8 ( 4 ) page: 2982 - 2990   2021.8

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    DOI: 10.1002/ehf2.13388

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  26. Prognostic value of resting cardiac power index depends on mean arterial pressure in dilated cardiomyopathy Reviewed

    Morimoto Ryota, Mizutani Takashi, Araki Takashi, Oishi Hideo, Kimura Yuki, Kazama Shingo, Shibata Naoki, Kuwayama Tasuku, Hiraiwa Hiroaki, Kondo Toru, Furusawa Kenji, Okumura Takahiro, Murohara Toyoaki

    ESC HEART FAILURE   Vol. 8 ( 4 ) page: 3206 - 3213   2021.8

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    DOI: 10.1002/ehf2.13446

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  27. Prognostic impact of immune-related adverse events on patients with and without cardiovascular disease: a retrospective review Reviewed

    Kazama Shingo, Morimoto Ryota, Kimura Yuki, Shibata Naoki, Ozaki Reina, Araki Takashi, Mizutani Takashi, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Hiraiwa Hiroaki, Kondo Toru, Furusawa Kenji, Shimokata Tomoya, Okumura Takahiro, Bando Yasuko K., Ando Yuichi, Murohara Toyoaki

    CARDIO-ONCOLOGY   Vol. 7 ( 1 ) page: 26   2021.7

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    DOI: 10.1186/s40959-021-00112-z

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  28. Prognostic value of leucine/phenylalanine ratio as an amino acid profile of heart failure Reviewed

    Hiraiwa Hiroaki, Okumura Takahiro, Kondo Toru, Kato Toshiaki, Kazama Shingo, Kimura Yuki, Ishihara Toshikazu, Iwata Etsuo, Shimojo Masafumi, Kondo Sayano, Aoki Soichiro, Kanzaki Yasunori, Tanimura Daisuke, Sano Hiroaki, Awaji Yoshifumi, Yamada Sumio, Murohara Toyoaki

    HEART AND VESSELS   Vol. 36 ( 7 ) page: 965 - 977   2021.7

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    DOI: 10.1007/s00380-020-01765-z

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  29. Heart Failure Association, Heart Failure Society of America, and Japanese Heart Failure Society Position Statement on Endomyocardial Biopsy Reviewed International coauthorship

    SEFEROVI P. E. T. A. R. M., TSUTSUI H. I. R. O. Y. U. K. I., MCNAMARA D. E. N. N. I. S. M., RISTIC A. R. S. E. N. D., BASSO C. R. I. S. T. I. N. A., BOZKURT B. I. Y. K. E. M., COOPER L. E. S. L. I. E. T., FILIPPATOS G. E. R. A. S. I. M. O. S., IDE T. O. M. O. M. I., INOMATA T. A. K. A. Y. U. K. I., KLINGEL K. A. R. I. N., LINHART A. L. E. S., LYON A. L. E. X. A. N. D. E. R. R., MEHRA M. A. N. D. E. E. P. R., POLOVINA M. A. R. I. J. A., MILINKOVIC I. V. A. N., NAKAMURA K. A. Z. U. F. U. M. I, ANKER S. T. E. F. A. N. D., VELJIC I. V. A. N. A., OHTANI T. O. M. O. H. I. T. O., OKUMURA T. A. K. A. H. I. R. O., THUM T. H. O. M. A. S., TSCHOEPE C. A. R. S. T. E. N., ROSANO G. I. U. S. E. P. P. E., COATS A. N. D. R. E. W. J. S., STARLING R. A. N. D. A. L. L. C.

    JOURNAL OF CARDIAC FAILURE   Vol. 27 ( 7 ) page: 727 - 743   2021.7

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    DOI: 10.1016/j.cardfail.2021.04.010

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  30. Ten-Year Mortality in Patients With ST-Elevation Myocardial Infarction Reviewed

    Watanabe Naoki, Takagi Kensuke, Tanaka Akihito, Yoshioka Naoki, Morita Yasuhiro, Yoshida Ruka, Kanzaki Yasunori, Nagai Hiroaki, Yamauchi Ryota, Komeyama Shotaro, Sugiyama Hiroki, Shimojo Kazuki, Imaoka Takuro, Sakamoto Gaku, Ohi Takuma, Goto Hiroki, Okumura Takahiro, Ishii Hideki, Morishima Itsuro, Murohara Toyoaki

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 149   page: 9 - 15   2021.6

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    DOI: 10.1016/j.amjcard.2021.03.008

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  31. Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy Reviewed International coauthorship

    Seferovic Petar M., Tsutsui Hiroyuki, McNamara Dennis M., Ristic Arsen D., Basso Cristina, Bozkurt Biykem, Cooper Leslie T. Jr., Filippatos Gerasimos, Ide Tomomi, Inomata Takayuki, Klingel Karin, Linhart Ales, Lyon Alexander R., Mehra Mandeep R., Polovina Marija, Milinkovic Ivan, Nakamura Kazufumi, Anker Stefan D., Veljic Ivana, Ohtani Tomohito, Okumura Takahiro, Thum Thomas, Tschope Carsten, Rosano Giuseppe, Coats Andrew J. S., Starling Randall C.

    EUROPEAN JOURNAL OF HEART FAILURE   Vol. 23 ( 6 ) page: 854 - 871   2021.6

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    DOI: 10.1002/ejhf.2190

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  32. Two cases of dilated cardiomyopathy with blood pressure-limited tolerability of cardioprotective agents improved by ivabradine. Reviewed

    Okumura T, Hiraiwa H, Araki T, Mizutani T, Kimura Y, Kazama S, Shibata N, Oishi H, Kuwayama T, Kondo T, Morimoto R, Murohara T

    Journal of cardiology cases   Vol. 23 ( 4 ) page: 149 - 153   2021.4

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    DOI: 10.1016/j.jccase.2020.11.007

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  33. Association between splenic volume and pulsatility index in patients with left ventricular assist devices Reviewed

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Kondo Toru, Kazama Shingo, Kimura Yuki, Shibata Naoki, Arao Yoshihito, Oishi Hideo, Kato Hiroo, Kuwayama Tasuku, Yamaguchi Shogo, Furusawa Kenji, Morimoto Ryota, Fujimoto Kazuro, Mutsuga Masato, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 4 ) page: 282 - 287   2021.4

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    DOI: 10.1177/0391398820957019

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  34. A clinical score for predicting left ventricular reverse remodelling in patients with dilated cardiomyopathy Reviewed

    Kimura Yuki, Okumura Takahiro, Morimoto Ryota, Kazama Shingo, Shibata Naoki, Oishi Hideo, Araki Takashi, Mizutani Takashi, Kuwayama Tasuku, Hiraiwa Hiroaki, Kondo Toru, Murohara Toyoaki

    ESC HEART FAILURE   Vol. 8 ( 2 ) page: 1359 - 1368   2021.4

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    DOI: 10.1002/ehf2.13216

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  35. A case of heart failure complicated with double ventricular response triggered by beta blocker. Reviewed

    Kazama S, Kondo T, Suga K, Yanagisawa S, Morimoto R, Okumura T, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 7 ( 3 ) page: 174 - 177   2021.3

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    DOI: 10.1016/j.hrcr.2020.12.004

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  36. Associations between hemodynamic parameters at rest and exercise capacity in patients with implantable left ventricular assist devices Reviewed

    Kondo Toru, Okumura Takahiro, Oishi Hideo, Arao Yoshihito, Kato Hiroo, Yamaguchi Shogo, Kuwayama Tasuku, Haga Tomoaki, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Fukaya Kenji, Sawamura Akinori, Morimoto Ryota, Mutsuga Masato, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 3 ) page: 174 - 180   2021.3

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    DOI: 10.1177/0391398820949888

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  37. Impact of predictive value of Fibrosis-4 index in patients hospitalized for acute heart failure. Reviewed

    Shibata N, Kondo T, Kazama S, Kimura Y, Oishi H, Arao Y, Kato H, Yamaguchi S, Kuwayama T, Hiraiwa H, Morimoto R, Okumura T, Sumi T, Sawamura A, Shimizu K, Murohara T

    International journal of cardiology   Vol. 324   page: 90 - 95   2021.2

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    DOI: 10.1016/j.ijcard.2020.09.056

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  38. Management perspectives from the 2019 Wuhan international workshop on fulminant myocarditis. Reviewed

    Veronese G, Ammirati E, Chen C, Klingel K, Suzuki M, Okumura T, Maisch B, Zuo H, Ni L, Jiang J, Zhang J, Wang H, Zhou N, Tschope C, Cooper LT, Wang DW

    International journal of cardiology   Vol. 324   page: 131 - 138   2021.2

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    DOI: 10.1016/j.ijcard.2020.10.063

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  39. Predictors of residual mitral regurgitation after left ventricular assist device implantation Reviewed

    Kimura Yuki, Okumura Takahiro, Kazama Shingo, Shibata Naoki, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Kato Hiroo, Yamaguchi Shogo, Hiraiwa Hiroaki, Kondo Toru, Morimoto Ryota, Mutsuga Masato, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 2 ) page: 101 - 109   2021.2

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    DOI: 10.1177/0391398820942526

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  40. Tricuspid regurgitation pressure gradient identifies prognostically relevant worsening renal function in acute heart failure. Reviewed

    Hayasaka K, Matsue Y, Kitai T, Okumura T, Kida K, Oishi S, Akiyama E, Suzuki S, Yamamoto M, Mizukami A, Yoshioka K, Kuroda S, Kagiyama N, Yamaguchi T, Sasano T

    European heart journal cardiovascular Imaging   Vol. 22 ( 2 ) page: 203 - 209   2021.2

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    DOI: 10.1093/ehjci/jeaa035

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  41. A case of reexpansion pulmonary edema and acute pulmonary thromboembolism associated with diffuse large B-cell lymphoma treated with venovenous extracorporeal membrane oxygenation. Reviewed

    Kazama S, Hiraiwa H, Kimura Y, Ozaki R, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Furusawa K, Morimoto R, Okumura T, Bando YK, Sato T, Shimada K, Kiyoi H, Nakamura G, Yasuda Y, Kasugai D, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Goto Y, Matsuda N, Murohara T

    Journal of cardiology cases   Vol. 23 ( 1 ) page: 53 - 56   2021.1

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    DOI: 10.1016/j.jccase.2020.08.013

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  42. Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device Reviewed

    Oishi Hideo, Kondo Toru, Fujimoto Kazuro, Mutsuga Masato, Morimoto Ryota, Hirano Ken-ichi, Sawamura Akinori, Kazama Shingo, Kimura Yuki, Shibata Naoki, Kato Hiroo, Arao Yoshihito, Kuwayama Tasuku, Yamaguchi Shogo, Hiraiwa Hiroaki, Okumura Takahiro, Usui Akihiko, Murohara Toyoaki

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 23 ( 4 ) page: 378 - 382   2020.12

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    DOI: 10.1007/s10047-020-01184-x

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  43. Relative bradycardia as a clinical feature in patients with coronavirus disease 2019 (COVID-19): A report of two cases. Reviewed

    Hiraiwa H, Goto Y, Nakamura G, Yasuda Y, Sakai Y, Kasugai D, Jinno S, Tanaka T, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Kondo T, Morimoto R, Okumura T, Matsuda N, Murohara T

    Journal of cardiology cases   Vol. 22 ( 6 ) page: 260 - 264   2020.12

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    DOI: 10.1016/j.jccase.2020.07.015

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  44. Differential Diagnosis of Mechanisms of Exercise-Induced Abnormal Blood Pressure Response in Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction. Reviewed

    Okumura T, Kano N, Sawamura A, Kondo T, Hiraiwa H, Morimoto R, Murohara T

    Circulation. Heart failure     page: CIRCHEARTFAILURE120007164   2020.10

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    DOI: 10.1161/CIRCHEARTFAILURE.120.007164

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  45. Impella 5.0 for Cardiogenic Shock After Thrombectomy in a Patient With Intraventricular Thrombosis. Reviewed

    Kimura Y, Kondo T, Mutsuga M, Morimoto R, Kazama S, Shibata N, Oishi H, Arao Y, Kuwayama T, Kato H, Yamaguchi S, Hiraiwa H, Okumura T, Fujimoto K, Usui A, Murohara T

    The Canadian journal of cardiology   Vol. 36 ( 10 ) page: 1690.e13-1690.e15   2020.10

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    DOI: 10.1016/j.cjca.2020.04.005

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  46. Prognostic Value of Delirium in Patients With Acute Heart Failure in the Intensive Care Unit. Reviewed

    Iwata E, Kondo T, Kato T, Okumura T, Nishiyama I, Kazama S, Ishihara T, Kondo S, Hiraiwa H, Tsuda T, Ito M, Aoyama M, Tanimura D, Awaji Y, Unno K, Murohara T

    The Canadian journal of cardiology   Vol. 36 ( 10 ) page: 1649-1657   2020.10

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    DOI: 10.1016/j.cjca.2020.01.006

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  47. Adolescent Kawasaki disease shock syndrome with inflammatory cell infiltration into the myocardium: a case report. Reviewed

    Sugiura Y, Okumura T, Kondo T, Murohara T

    European heart journal. Case reports   Vol. 4 ( 5 ) page: 1 - 7   2020.10

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    DOI: 10.1093/ehjcr/ytaa304

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  48. Myocardial Vasculitis Associated With the Immune Checkpoint Inhibitor Pembrolizumab. Reviewed

    Oishi H, Morimoto R, Shimoyama Y, Kuroda K, Urata T, Kondo T, Okumura T, Bando YK, Akiyama M, Murohara T

    JACC. Case reports   Vol. 2 ( 12 ) page: 1937 - 1941   2020.10

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    DOI: 10.1016/j.jaccas.2020.07.028

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  49. Efficacy of Pulmonary Artery Pulsatility Index as a Measure of Right Ventricular Dysfunction in Stable Phase of Dilated Cardiomyopathy Reviewed

    Kuwayama Tasuku, Morimoto Ryota, Oishi Hideo, Kato Hiroo, Kimura Yuki, Kazama Shingo, Shibata Naoki, Arao Yoshihito, Yamaguchi Shogo, Hiraiwa Hiroaki, Kondo Toru, Furusawa Kenji, Okumura Takahiro, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 84 ( 9 ) page: 1536 - +   2020.9

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    DOI: 10.1253/circj.CJ-20-0279

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  50. Clinical and Prognostic Values of ALBI Score in Patients With Acute Heart Failure. Reviewed

    Matsue Y, Kagiyama N, Yamaguchi T, Kuroda S, Okumura T, Kida K, Mizuno A, Oishi S, Inuzuka Y, Akiyama E, Matsukawa R, Kato K, Suzuki S, Naruke T, Yoshioka K, Miyoshi T, Baba Y, Yamamoto M, Mizutani K, Yoshida K, Kitai T

    Heart, lung & circulation   Vol. 29 ( 9 ) page: 1328 - 1337   2020.9

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    DOI: 10.1016/j.hlc.2019.12.003

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  51. Pulmonary artery pressure may be a predictor of closed aortic valve in patients managed by venoarterial extracorporeal membrane oxygenation Reviewed

    Yamaguchi Shogo, Sawamura Akinori, Okumura Takahiro, Kato Hiroo, Oishi Hideo, Arao Yoshihito, Haga Tomoaki, Kuwayama Tasuku, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Kondo Toru, Morimoto Ryota, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 43 ( 9 ) page: 594 - 599   2020.9

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    DOI: 10.1177/0391398820901841

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  52. Successful weaning from veno-arterial ECMO and Impella2.5 by veno-venous and arterial ECMO (v-ECPELLA) for a patient with acute myocardial infarction complicated by severe lung injury. Reviewed

    Shimizu S, Shimano M, Shibata Y, Hanaki Y, Kamiya H, Morimoto R, Okumura T, Murohara T

    Journal of cardiology cases   Vol. 22 ( 3 ) page: 103-106   2020.9

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    DOI: 10.1016/j.jccase.2020.05.004

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  53. Fulminant myocarditis with myositis of ocular and respiratory muscles Reviewed

    Hiraiwa Hiroaki, Furusawa Kenji, Kazama Shingo, Kimura Yuki, Shibata Naoki, Arao Yoshihito, Oishi Hideo, Kato Hiroo, Kuwayama Tasuku, Yamaguchi Shogo, Kondo Toru, Sawamura Akinori, Morimoto Ryota, Okumura Takahiro, Murohara Toyoaki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page: 585-593   2020.8

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    DOI: 10.18999/nagjms.82.3.585

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  54. Spleen size improvement in advanced heart failure patients using a left ventricular assist device Reviewed

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Kondo Toru, Kazama Shingo, Kimura Yuki, Shibata Naoki, Arao Yoshihito, Oishi Hideo, Kato Hiroo, Kuwayama Tasuku, Yamaguchi Shogo, Furusawa Kenji, Morimoto Ryota, Murohara Toyoaki

    ARTIFICIAL ORGANS   Vol. 44 ( 7 ) page: 700 - 708   2020.7

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    DOI: 10.1111/aor.13658

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  55. Viral genome search in myocardium of patients with fulminant myocarditis Reviewed

    Veronese Giacomo, Ammirati Enrico, Brambatti Michela, Merlo Marco, Cipriani Manlio, Potena Luciano, Sormani Paola, Aoki Tatsuo, Sugimura Koichiro, Sawamura Akinori, Okumura Takahiro, Pinney Sean, Hong Kimberly, Shah Palak, Braun Oscar O., van de Heyning Caroline M., Montero Santiago, Petrella Duccio, Huang Florent, Schmidt Matthieu, Raineri Claudia, Lala Anuradha, Varrenti Marisa, Foa Alberto, Leone Ornella, Gentile Piero, Artico Jessica, Agostini Valentina, Patel Rajiv, Garascia Andrea, Van Craenenbroeck Emeline M., Hirose Kaoru, Isotani Akihiro, Murohara Toyoaki, Arita Yoh, Sionis Alessandro, Fabris Enrico, Hashem Sherin, Garcia-Hernando Victor, Oliva Fabrizio, Greenberg Barry, Shimokawa Hiroaki, Sinagra Gianfranco, Adler Eric D., Frigerio Maria, Camici Paolo G.

    EUROPEAN JOURNAL OF HEART FAILURE   Vol. 22 ( 7 ) page: 1277 - 1280   2020.7

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    DOI: 10.1002/ejhf.1738

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  56. Usefulness of Plasma Branched-Chain Amino Acid Analysis in Predicting Outcomes of Patients with Nonischemic Dilated Cardiomyopathy Reviewed

    Kimura Yuki, Okumura Takahiro, Kazama Shingo, Shibata Naoki, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Kato Hiroo, Yamaguchi Shogo, Hiraiwa Hiroaki, Kondo Toru, Morimoto Ryota, Murohara Toyoaki

    INTERNATIONAL HEART JOURNAL   Vol. 61 ( 4 ) page: 739 - 747   2020.7

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    DOI: 10.1536/ihj.20-010

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  57. Impact of brain natriuretic peptide reduction on the worsening renal function in patients with acute heart failure Reviewed

    Yoshioka Kenji, Matsue Yuya, Okumura Takahiro, Kida Keisuke, Oishi Shogo, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Mizukami Akira, Kuroda Shunsuke, Kagiyama Nobuyuki, Yamaguchi Tetsuo, Sasano Tetsuo, Matsumura Akihiko, Kitai Takeshi

    PLOS ONE   Vol. 15 ( 6 ) page: e0235493   2020.6

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    DOI: 10.1371/journal.pone.0235493

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  58. Usefulness of the plasma branched-chain amino acid/Aromatic amino acid ratio for predicting future cardiac events in patients with heart failure Reviewed

    Hiraiwa Hiroaki, Okumura Takahiro, Kondo Toru, Kato Toshiaki, Kazama Shingo, Ishihara Toshikazu, Iwata Etsuo, Shimojo Masafumi, Kondo Sayano, Aoki Soichiro, Kanzaki Yasunori, Tanimura Daisuke, Sano Hiroaki, Awaji Yoshifumi, Yamada Sumio, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 75 ( 6 ) page: 689 - 696   2020.6

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    DOI: 10.1016/j.jjcc.2019.12.016

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  59. Validation of the Larissa Heart Failure Risk Score for risk stratification in acute heart failure.

    Kitai T, Xanthopoulos A, Tang WHW, Kaji S, Furukawa Y, Oishi S, Akiyama E, Suzuki S, Yamamoto M, Kida K, Okumura T, Skoularigis J, Triposkiadis F, Matsue Y

    International journal of cardiology   Vol. 307   page: 119 - 124   2020.5

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    DOI: 10.1016/j.ijcard.2019.12.051

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  60. Validation of the Larissa Heart Failure Risk Score for risk strati fication in acute heart failure Reviewed

    Kitai Takeshi, Xanthopoulos Andrew, Tang W. H. Wilson, Kaji Shuichiro, Furukawa Yutaka, Oishi Shogo, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Kida Keisuke, Okumura Takahiro, Skoularigis John, Triposkiadis Filippos, Matsue Yuya

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 307   page: 119 - 124   2020.5

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  61. Prediction of Thromboembolism in Patients With Hypertrophic Cardiomyopathy Invited Reviewed

    Okumura Takahiro, Kimura Yuki, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 84 ( 5 ) page: 700 - 701   2020.5

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    DOI: 10.1253/circj.CJ-20-0250

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  62. Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device Reviewed

    Hiraiwa Hiroaki, Okumura Takahiro, Shimizu Shinya, Arao Yoshihito, Oishi Hideo, Kato Hiroo, Kuwayama Tasuku, Yamaguchi Shogo, Haga Tomoaki, Yokoi Tsuyoshi, Kondo Toru, Sugiura Yuki, Kano Naoaki, Watanabe Naoki, Fukaya Kenji, Furusawa Kenji, Sawamura Akinori, Morimoto Ryota, Fujimoto Kazuro, Mutsuga Masato, Usui Akihiko, Murohara Toyoaki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 1 ) page: 129 - 134   2020.2

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    DOI: 10.18999/nagjms.82.1.129

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  63. Advantages and Emerging Problems of Novel Treatments for Transthyretin Cardiac Amyloidosis Invited Reviewed

    Okumura Takahiro, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 84 ( 1 ) page: 9 - 10   2020.1

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    DOI: 10.1253/circj.CJ-19-1044

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  64. Giant cell myocarditis with central diabetes insipidus: A case report. Reviewed

    Yamaguchi S, Sawamura A, Nakaguro M, Shimoyama Y, Morimoto R, Kato H, Arao Y, Oishi H, Haga T, Kuwayama T, Yokoi T, Hiraiwa H, Kondo T, Okumura T, Murohara T

    Journal of cardiology cases   Vol. 21 ( 1 ) page: 8-11   2020.1

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    DOI: 10.1016/j.jccase.2019.08.011

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  65. Potential prognostic implications of myocardial thallium-201 and iodine-123-beta-methylpentadecanoic acid dual scintigraphy in patients with Anderson-Fabry disease Reviewed

    Haga Tomoaki, Okumura Takahiro, Isobe Satoshi, Somura Fuji, Kano Naoaki, Kuwayama Tasuku, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Kondo Toru, Sawamura Akinori, Morimoto Ryota, Yamamoto Hiroshi, Tsuboi Kazuya, Murohara Toyoaki

    ANNALS OF NUCLEAR MEDICINE   Vol. 33 ( 12 ) page: 930 - 936   2019.12

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    DOI: 10.1007/s12149-019-01406-0

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  66. Safety and Prognostic Impact of Early Treatment with Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients with Acute Heart Failure Reviewed

    Yoshioka Kenji, Matsue Yuya, Yamaguchi Tetsuo, Kitai Takeshi, Kagiyama Nobuyuki, Okumura Takahiro, Kida Keisuke, Oishi Shogo, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Kuroda Shunsuke, Matsumura Akihiko, Hirao Kenzo

    AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS   Vol. 19 ( 6 ) page: 597 - 605   2019.12

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    DOI: 10.1007/s40256-019-00355-3

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  67. Prognostic impact of mitral L-wave in patients with hypertrophic cardiomyopathy without risk factors for sudden cardiac death Reviewed

    Sugiura Yuki, Morimoto Ryota, Aoki Soichiro, Yamaguchi Shogo, Haga Tomoaki, Kuwayama Tasuku, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Kondo Toru, Watanabe Naoki, Kano Naoaki, Fukaya Kenji, Sawamura Akinori, Okumura Takahiro, Murohara Toyoaki

    HEART AND VESSELS   Vol. 34 ( 12 ) page: 2002 - 2010   2019.12

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    DOI: 10.1007/s00380-019-01440-y

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  68. Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin Reviewed

    Sakaguchi Teruhiro, Takefuji Mikito, Wettschureck Nina, Hamaguchi Tomonari, Amano Mutsuki, Kato Katsuhiro, Tsuda Takuma, Eguchi Shunsuke, Ishihama Sohta, Mori Yu, Yura Yoshimitsu, Yoshida Tatsuya, Unno Kazumasa, Okumura Takahiro, Ishii Hideki, Shimizu Yuuki, Bando Yasuko K., Ohashi Koji, Ouchi Noriyuki, Enomoto Atsushi, Offermanns Stefan, Kaibuchi Kozo, Murohara Toyoaki

    CIRCULATION   Vol. 140 ( 21 ) page: 1737 - 1752   2019.11

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    DOI: 10.1161/CIRCULATIONAHA.119.041019

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  69. Heart rate control using beta-blockers for heart failure with atrial fibrillation: more than enough is too much. Invited Reviewed

    Okumura T, Kimura Y, Murohara T

    Hypertension research : official journal of the Japanese Society of Hypertension   Vol. 42 ( 11 ) page: 1826-1827   2019.11

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    DOI: 10.1038/s41440-019-0303-x

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  70. Neuromuscular electrical stimulation is feasible in patients with acute heart failure Reviewed

    Kondo Toru, Yamada Sumio, Tanimura Daisuke, Kazama Shingo, Ishihara Toshikazu, Shimojo Masafumi, Iwata Etsuo, Kondo Sayano, Hiraiwa Hiroaki, Kato Toshiaki, Sano Hiroaki, Awaji Yoshifumi, Okumura Takahiro, Murohara Toyoaki

    ESC HEART FAILURE   Vol. 6 ( 5 ) page: 975 - 982   2019.10

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    DOI: 10.1002/ehf2.12504

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  71. Unsolved Issue in Left Ventricular Noncompaction: Is the Strange Form of Myocardium Congenital or Acquired? Reviewed

    Okumura Takahiro, Murohara Toyoaki

    CARDIOLOGY   Vol. 143 ( 3-4 ) page: 105 - 106   2019.10

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    DOI: 10.1159/000501585

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  72. Early Blood Pressure Reduction by Intravenous Vasodilators Is Associated With Acute Kidney Injury in Patients With Hypertensive Acute Decompensated Heart Reviewed

    Arao Yoshihito, Sawamura Akinori, Nakatochi Masahiro, Okumura Takahiro, Kato Hiroo, Oishi Hideo, Yamaguchi Shogo, Haga Tomoaki, Kuwayama Tasuku, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Kondo Toru, Morimoto Ryota, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 83 ( 9 ) page: 1883 - +   2019.9

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    DOI: 10.1253/circj.CJ-19-0333

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  73. Prognostic Value of BNP Reduction During Hospitalization in Patients With Acute Heart Failure Reviewed

    Kagiyama Nobuyuki, Kitai Takeshi, Hayashida Akihiro, Yamaguchi Tetsuo, Okumura Takahiro, Kida Keisuke, Mizuno Atsushi, Oishi Shogo, Inuzuka Yasutaka, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Shimizu Akane, Urakami Yu, Toki Misako, Aritaka Shingo, Matsumoto Kozue, Nagano Noriko, Yamamoto Keizo, Matsue Yuya

    JOURNAL OF CARDIAC FAILURE   Vol. 25 ( 9 ) page: 712 - 721   2019.9

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    DOI: 10.1016/j.cardfail.2019.04.004

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  74. Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction Reviewed

    Hara Akitoshi, Kobayashi Hiroki, Asai Naoya, Saito Shigeyoshi, Higuchi Takahiro, Kato Katsuhiro, Okumura Takahiro, Bando Yasuko K., Takefuji Mikito, Mizutani Yasuyuki, Miyai Yuki, Saito Shoji, Maruyama Shoichi, Maeda Keiko, Ouchi Noriyuki, Nagasaka Arata, Miyata Takaki, Mii Shinji, Kioka Noriyuki, Worthley Daniel L., Murohara Toyoaki, Takahashi Masahide, Enomoto Atsushi

    CIRCULATION RESEARCH   Vol. 125 ( 4 ) page: 414 - 430   2019.8

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    DOI: 10.1161/CIRCRESAHA.119.314806

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  75. Left Ventricular Relaxation Half-Time as a Predictor of Cardiac Events in Idiopathic Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy With Left Ventricular Systolic and/or Diastolic Dysfunction Reviewed

    Yokoi Tsuyoshi, Morimoto Ryota, Oishi Hideo, Kato Hiroo, Arao Yoshihito, Yamaguchi Shogo, Kuwayama Tasuku, Haga Tomoaki, Hiraiwa Hiroaki, Kondo Toni, Furusawa Kenji, Fukaya Kenji, Sawamura Akinori, Okumura Takahiro, Hirashiki Akihiro, Murohara Toyoaki

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 124 ( 3 ) page: 435 - 441   2019.8

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    DOI: 10.1016/j.amjcard.2019.05.005

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  76. Fulminant Versus Acute Nonfulminant Myocarditis in Patients With Left Ventricular Systolic Dysfunction Reviewed

    Ammirati Enrico, Veronese Giacomo, Brambatti Michela, Merlo Marco, Cipriani Manlio, Potena Luciano, Sormani Paola, Aoki Tatsuo, Sugimura Koichiro, Sawamura Akinori, Okumura Takahiro, Pinney Sean, Hong Kimberly, Shah Palak, Braun Oscar, Van de Heyning Caroline M., Montero Santiago, Petrella Duccio, Huang Florent, Schmidt Matthieu, Raineri Claudia, Lala Anuradha, Varrenti Marisa, Foa Alberto, Leone Ornella, Gentile Piero, Artico Jessica, Agostini Valentina, Patel Rajiv, Garascia Andrea, Van Craenenbroeck Emeline M., Hirose Kaoru, Isotani Akihiro, Murohara Toyoaki, Arita Yoh, Sionis Alessandro, Fabris Enrico, Hashem Sherin, Garcia-Hernando Victor, Oliva Fabrizio, Greenberg Barry, Shimokawa Hiroaki, Sinagra Gianfranco, Adler Eric D., Frigerio Maria, Camici Paolo G.

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   Vol. 74 ( 3 ) page: 299 - 311   2019.7

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    DOI: 10.1016/j.jacc.2019.04.063

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  77. CUFF-LESS BLOOD PRESSURE MONITORING DURING SLEEP Reviewed

    Noda A., Mita Y., Miyata S., Ando M., Okumura T.

    JOURNAL OF HYPERTENSION   Vol. 37   page: E254 - E254   2019.7

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    DOI: 10.1097/01.hjh.0000573244.64731.f2

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  78. A survival case of a young adult patient with ST-elevated myocardial infarction with high levels of lipoprotein(a). Reviewed

    Hiraiwa H, Morimoto R, Okumura T, Arao Y, Oishi H, Kato H, Yamaguchi S, Kuwayama T, Haga T, Yokoi T, Kondo T, Watanabe N, Mitsuda T, Fukaya K, Sawamura A, Tanaka A, Ishii H, Morishima I, Tsuboi H, Murohara T

    Journal of cardiology cases   Vol. 19 ( 6 ) page: 207-210   2019.6

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    DOI: 10.1016/j.jccase.2019.02.004

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  79. Gatekeeping in an inpatient rehabilitation facility to reduce morbidity and mortality due to cardiac disease: screening program using of BNP and ECG Auto-diagnosis Reviewed

    Kano Naoaki, Kato Toyonori, Tomohara Takiko, Futamura Yukiko, Yoshida Shogo, Okumura Takahiro, Maeda Kcngo, Murohara Toyoaki, Oda Koji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 303 - 312   2019.5

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    DOI: 10.18999/nagjms.81.2.303

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  80. Specialty-Related Differences in the Acute-Phase Treatment and Prognosis in Patients With Acute Heart Failure - Insights From REALITY-AHF - Reviewed

    Kondo Toru, Okumura Takahiro, Matsue Yuya, Shiraishi Atsushi, Kagiyama Nobuyuki, Yamaguchi Tetsuo, Kuroda Shunsuke, Kida Keisuke, Mizuno Atsushi, Oishi Shogo, Inuzuka Yasutaka, Akiyama Eiichi, Matsukawa Ryuichi, Kato Kota, Suzuki Satoshi, Naruke Takashi, Yoshioka Kenji, Miyoshi Tatsuya, Baba Yuichi, Yamamoto Masayoshi, Murai Koji, Mizutani Kazuo, Yoshida Kazuki, Kitai Takeshi, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 83 ( 1 ) page: 174 - +   2019.1

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    DOI: 10.1253/circj.CJ-18-0724

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  81. Very Early Diuretic Response After Admission for Acute Heart Failure. Reviewed

    Kuroda S, Damman K, Ter Maaten JM, Voors AA, Okumura T, Kida K, Oishi S, Akiyama E, Suzuki S, Yamamoto M, Kitai T, Yoshida K, Matsumura A, Matsue Y

    Journal of cardiac failure   Vol. 25 ( 1 ) page: 12-19   2019.1

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    DOI: 10.1016/j.cardfail.2018.09.004

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  82. Hemodynamics of cardiac tamponade during extracorporeal membrane oxygenation support in a patient with fulminant myocarditis. Reviewed

    Kondo T, Morimoto R, Yokoi T, Yamaguchi S, Kuwayama T, Haga T, Hiraiwa H, Sugiura Y, Watanabe N, Kano N, Ichii T, Fukaya K, Sawamura A, Okumura T, Yoshizumi T, Mutsuga M, Fujimoto K, Matsuda N, Usui A, Murohara T

    Journal of cardiology cases   Vol. 19 ( 1 ) page: 22-24   2019.1

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    DOI: 10.1016/j.jccase.2018.08.009

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  83. Assessment of abdominal aortic calcification by computed tomography for prediction of latent left ventricular stiffness and future cardiovascular risk in pre-dialysis patients with chronic kidney disease: A single center cross-sectional study Reviewed

    Furusawa Kenji, Takeshita Kyosuke, Suzuki Susumu, Tatami Yosuke, Morimoto Ryota, Okumura Takahiro, Yasuda Yoshinari, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF MEDICAL SCIENCES   Vol. 16 ( 7 ) page: 939 - 948   2019

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    DOI: 10.7150/ijms.32629

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  84. Palliative and end-of-life care for heart failure patients in an aging society Invited Reviewed

    Okumura Takahiro, Sawamura Akinori, Murohara Toyoaki

    KOREAN JOURNAL OF INTERNAL MEDICINE   Vol. 33 ( 6 ) page: 1039 - 1049   2018.11

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    DOI: 10.3904/kjim.2018.106

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  85. Left ventricular phase entropy: Novel prognostic predictor in patients with dilated cardiomyopathy and narrow QRS Reviewed

    Kano Naoaki, Okumura Takahiro, Isobe Satoshi, Sawamura Akinori, Watanabe Naoki, Fukaya Kenji, Mori Hiroaki, Morimoto Ryota, Kato Katsuhiko, Bando Yasuko K., Murohara Toyoaki

    JOURNAL OF NUCLEAR CARDIOLOGY   Vol. 25 ( 5 ) page: 1677 - 1687   2018.10

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    DOI: 10.1007/s12350-017-0807-1

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  86. Randomized Trial of Effect of Urate-Lowering Agent Febuxostat in Chronic Heart Failure Patients with Hyperuricemia (LEAF-CHF ) Study Design Reviewed

    Yokota Takashi, Fukushima Arata, Kinugawa Shintaro, Okumura Takahiro, Murohara Toyoaki, Tsutsui Hiroyuki

    INTERNATIONAL HEART JOURNAL   Vol. 59 ( 5 ) page: 976 - 982   2018.9

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    DOI: 10.1536/ihj.17-560

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  87. Prognostic Value of Electrocardiography in Patients With Fulminant Myocarditis Supported by Percutaneous Venoarterial Extracorporeal Membrane Oxygenation - Analysis From the CHANGE PUMP Study - Reviewed

    Sawamura Akinori, Okumura Takahiro, Ito Masaaki, Ozaki Yukio, Ohte Nobuyuki, Amano Tetsuya, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 82 ( 8 ) page: 2089 - +   2018.8

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    DOI: 10.1253/circj.CJ-18-0136

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  88. Promising method for management of venoarterial extracorporeal membrane oxygenation: A case of severe heart failure successfully stabilized by "high-flow/vasodilation method". Reviewed

    Kondo T, Sawamura A, Okumura T, Kano N, Morimoto R, Watanabe N, Hiraiwa H, Kuwayama T, Sugiura Y, Haga T, Yamaguchi S, Fukaya K, Yokoi T, Fujimoto K, Mutsuga M, Yoshizumi T, Matsuda N, Usui A, Murohara T

    Journal of cardiology cases   Vol. 18 ( 2 ) page: 81 - 84   2018.8

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    DOI: 10.1016/j.jccase.2018.05.002

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  89. Are Sodium-Glucose Cotransporter 2 Inhibitors Really Useful and Safe for Advanced Heart Failure? Invited Reviewed

    Okumura Takahiro, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 82 ( 7 ) page: 1752 - 1753   2018.7

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    DOI: 10.1253/circj.CJ-18-0584

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  90. Impact of early treatment with intravenous vasodilators and blood pressure reduction in acute heart failure Reviewed

    Kitai Takeshi, Tang W. H. Wilson, Xanthopoulos Andrew, Murai Ryosuke, Yamane Takafumi, Kim Kitae, Oishi Shogo, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Kida Keisuke, Okumura Takahiro, Kaji Shuichiro, Furukawa Yutaka, Matsue Yuya

    OPEN HEART   Vol. 5 ( 2 ) page: e000845   2018.7

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    DOI: 10.1136/openhrt-2018-000845

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  91. Late-Onset Fulminant Myocarditis With Immune Checkpoint Inhibitor Nivolumab Reviewed

    Yamaguchi Shogo, Morimoto Ryota, Okumura Takahiro, Yamashita Yuta, Haga Tomoaki, Kuwayama Tasuku, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Kondo Toru, Sugiura Yuki, Watanabe Naoki, Kano Naoaki, Kohno Kei, Fukaya Kenji, Sawamura Akinori, Yokota Kenji, Ishii Hideki, Nakaguro Masato, Akiyama Masashi, Murohara Toyoaki

    CANADIAN JOURNAL OF CARDIOLOGY   Vol. 34 ( 6 ) page: 812.e1 - 812.e3   2018.6

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    DOI: 10.1016/j.cjca.2018.03.007

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  92. Prognostic significance of in-hospital coronary angiography in patients hospitalized with acute heart failure - results from REALITY-AHF Reviewed

    Akiyama E. Eiichi, Konishi M., Okumura T., Kida K., Oishi S., Suzuki S., Yamamoto M., Kitai T., Matsue Y.

    EUROPEAN JOURNAL OF HEART FAILURE   Vol. 20   page: 115-115   2018.5

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  93. Effect of Optimizing Guideline-Directed Medical Therapy Before Discharge on Mortality and Heart Failure Readmission in Patients Hospitalized With Heart Failure With Reduced Ejection Fraction Reviewed

    Yamaguchi Tetsuo, Kitai Takeshi, Miyamoto Takamichi, Kagiyama Nobuyuki, Okumura Takahiro, Kida Keisuke, Oishi Shogo, Akiyama Eiichi, Suzuki Satoshi, Yamamoto Masayoshi, Yamaguchi Junji, Iwai Takamasa, Hijikata Sadahiro, Masuda Ryo, Miyazaki Ryoichi, Hara Nobuhiro, Nagata Yasutoshi, Nozato Toshihiro, Matsue Yuya

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 121 ( 8 ) page: 969 - 974   2018.4

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    DOI: 10.1016/j.amjcard.2018.01.006

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  94. Skeletal Muscle Pump Function Is Associated With Exercise Capacity in Patients With Heart Failure Reviewed

    Kondo Toru, Yamada Sumio, Asai Chikako, Okumura Takahiro, Tanimura Daisuke, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 82 ( 4 ) page: 1033 - 1040   2018.4

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    DOI: 10.1253/circj.CJ-17-0927

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  95. Early Prediction Model for Successful Bridge to Recovery in Patients With Fulminant Myocarditis Supported With Percutaneous Venoarterial Extracorporeal Membrane Oxygenation. - Insights From the CHANGE PUMP Study Reviewed

    Sawamura Akinori, Okumura Takahiro, Hirakawa Akihiro, Ito Masaaki, Ozaki Yukio, Ohte Nobuyuki, Amano Tetsuya, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 82 ( 3 ) page: 699 - 707   2018.3

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    DOI: 10.1253/circj.CJ-17-0549

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  96. Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction Reviewed

    Tian Zhe, Miyata Keishi, Morinaga Jun, Horiguchi Haruki, Kadomatsu Tsuyoshi, Endo Motoyoshi, Zhao Jiabin, Zhu Shunshun, Sugizaki Taichi, Sato Michio, Terada Kazutoyo, Okumura Takahiro, Murohara Toyoaki, Oike Yuichi

    CIRCULATION JOURNAL   Vol. 82 ( 2 ) page: 437 - +   2018.2

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    DOI: 10.1253/circj.CJ-17-0327

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  97. 高齢者心不全-左室駆出率の保たれた心不全を中心に- Invited Reviewed

    奥村貴裕,室原豊明

    日本老年医学会雑誌   Vol. 55 ( 1 ) page: 34-40   2018.2

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  98. The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy (vol 71, pg 284, 2018)

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Sugiura Yuki, Kondo Toru, Watanabe Naoki, Aoki Soichiro, Ichii Takeo, Kitagawa Katsuhide, Kano Naoaki, Fukaya Kenji, Furusawa Kenji, Morimoto Ryota, Takeshita Kyosuke, Bando Yasuko K., Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 72 ( 1-2 ) page: 178 - 178   2018

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  99. The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy Reviewed

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Sugiura Yuki, Kondo Toru, Watanabe Naoki, Aoki Soichiro, Ichii Takeo, Kitagawa Katsuhide, Kano Naoaki, Fukaya Kenji, Furusawa Kenji, Morimoto Ryota, Takeshita Kyosuke, Bando Yasuko K., Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 71 ( 3-4 ) page: 284 - 290   2018

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    DOI: 10.1016/j.jjcc.2017.09.002

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  100. The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy reply Reviewed

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 72 ( 3-4 ) page: 266 - 266   2018

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    DOI: 10.1016/j.jjcc.2018.02.005

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  101. Development and Validation of a Novel Cuff-Less Blood Pressure Monitoring Device. Reviewed

      Vol. 2 ( 6 ) page: 631-642   2017.12

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    DOI: 10.1016/j.jacbts.2017.07.015

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  102. Sokolow-Lyon voltage is suitable for monitoring improvement in cardiac function and prognosis of patients with idiopathic dilated cardiomyopathy Reviewed

    Fukaya Kenji, Takeshita Kyosuke, Okumura Takahiro, Hiraiwa Hiroaki, Aoki Soichiro, Ichii Takeo, Sugiura Yuki, Kitagawa Katsuhide, Kondo Toru, Watanabe Naoki, Kano Naoaki, Furusawa Kenji, Sawamura Akinori, Morimoto Ryota, Bando Yasuko, Murohara Toyoaki

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   Vol. 22 ( 5 )   2017.9

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    DOI: 10.1111/anec.12431

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  103. Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction Reviewed

    Tsuda Takuma, Takefuji Mikito, Wettschureck Nina, Kotani Kazuhiko, Morimoto Ryota, Okumura Takahiro, Kaur Harmandeep, Eguchi Shunsuke, Sakaguchi Teruhiro, Ishihama Sohta, Kikuchi Ryosuke, Unno Kazumasa, Matsushita Kunihiro, Ishikawa Shizukiyo, Offermanns Stefan, Murohara Toyoaki

    JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 214 ( 7 ) page: 1877 - 1888   2017.7

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    DOI: 10.1084/jem.20161924

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  104. Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure Reviewed

    Matsue Yuya, Damman Kevin, Voors Adriaan A., Kagiyama Nobuyuki, Yamaguchi Tetsuo, Kuroda Shunsuke, Okumura Takahiro, Kida Keisuke, Mizuno Atsushi, Oishi Shogo, Inuzuka Yasutaka, Akiyama Eiichi, Matsukawa Ryuichi, Kato Kota, Suzuki Satoshi, Naruke Takashi, Yoshioka Kenji, Miyoshi Tatsuya, Baba Yuichi, Yamamoto Masayoshi, Murai Koji, Mizutani Kazuo, Yoshida Kazuki, Kitai Takeshi

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   Vol. 69 ( 25 ) page: 3042-3051   2017.6

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    DOI: 10.1016/j.jacc.2017.04.042

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  105. Usefulness of the Combination of In-Hospital Poor Diuretic Response and Systemic Congestion to Predict Future Cardiac Events in Patients With Acute Decompensated Heart Failure Reviewed

    Aoki Soichiro, Okumura Takahiro, Sawamura Akinori, Kitagawa Katsuhide, Morimoto Ryota, Sakakibara Masaki, Murohara Toyoaki

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 119 ( 12 ) page: 2010 - 2016   2017.6

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    DOI: 10.1016/j.amjcard.2017.03.030

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  106. Prognostic value of left ventricular dyssynchrony evaluated by gated myocardial perfusion imaging in patients with chronic kidney disease and normal perfusion defect scores. Reviewed

    Mori H, Isobe S, Suzuki S, Unno K, Morimoto R, Kano N, Okumura T, Yasuda Y, Kato K, Murohara T

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     2017.4

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    DOI: 10.1007/s12350-017-0889-9

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  107. Association between plaque characteristics and the amount of debris captured by a filter-type distal protection device in patients with acute coronary syndrome Reviewed

    Kitagawa Katsuhide, Amano Tetsuya, Uetani Tadayuki, Ishii Hideki, Okumura Takahiro, Suzuki Susumu, Takashima Hiroaki, Kurita Akiyoshi, Ando Hirohiko, Matsubara Tatsuaki, Murohara Toyoaki

    ATHEROSCLEROSIS   Vol. 258   page: 72 - 78   2017.3

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    DOI: 10.1016/j.atherosclerosis.2017.02.001

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  108. Long-Term Pathological Follow-Up of Myocardium in a Carrier of Duchenne Muscular Dystrophy With Dilated Cardiomyopathy Reviewed

    Kondo Toru, Okumura Takahiro, Takefuji Mikito, Hiraiwa Hiroaki, Sugiura Yuki, Watanabe Naoki, Aoki Soichiro, Ichii Takeo, Kitagawa Katsuhide, Kano Naoaki, Fukaya Kenji, Furusawa Kenji, Sawamura Akinori, Morimoto Ryota, Bando Yasuko K., Takemura Genzou, Murohara Toyoaki

    CIRCULATION-HEART FAILURE   Vol. 10 ( 3 ) page: e003826   2017.3

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    DOI: 10.1161/CIRCHEARTFAILURE.117.003826

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  109. Biphasic Force-Frequency Relation Predicts Primary Cardiac Events in Patients With Hypertrophic Cardiomyopathy Reviewed

    Morimoto Ryota, Okumura Takahiro, Bando Yasuko K., Fukaya Kenji, Sawamura Akinori, Kawase Haruya, Shimizu Shinya, Shimazu Shuzo, Hirashiki Akihiro, Takeshita Kyosuke, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 81 ( 3 ) page: 368 - 375   2017.3

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    DOI: 10.1253/circj.CJ-16-1007

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  110. Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy Reviewed

    Morimoto Ryota, Okumura Takahiro, Hirashiki Akihiro, Ishii Hideki, Ichii Takeo, Aoki Soichiro, Furusawa Kenji, Hiraiwa Hiroaki, Kondo Toru, Watanabe Naoki, Kano Naoaki, Fukaya Kenji, Sawamura Akinori, Takeshita Kyosuke, Bando Yasuko K., Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 70 ( 3-4 ) page: 303 - 309   2017

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    DOI: 10.1016/j.jjcc.2017.02.005

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  111. Impact of Renal Functional/Morphological Dynamics on the Calcification of Coronary and Abdominal Arteries in Patients with Chronic Kidney Disease Reviewed

    Ichii Takeo, Morimoto Ryota, Okumura Takahiro, Ishii Hideki, Tatami Yosuke, Yamamoto Dai, Aoki Soichiro, Hiraiwa Hiroaki, Furusawa Kenji, Kondo Toru, Watanabe Naoki, Kano Naoaki, Fukaya Kenji, Sawamura Akinori, Suzuki Susumu, Yasuda Yoshinari, Murohara Toyoaki

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 24 ( 11 ) page: 1092 - 1104   2017

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    DOI: 10.5551/jat.39271

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  112. Impact of red blood cell distribution width on non-cardiac mortality in patients with acute decompensated heart failure with preserved ejection fraction Reviewed

    Imai Ryo, Uemura Yusuke, Okumura Takahiro, Takemoto Kenji, Uchikawa Tomohiro, Koyasu Masayoshi, Ishikawa Shinji, Iwamiya Satoshi, Ozaki Yuta, Shibata Rei, Watarai Masato, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 70 ( 5-6 ) page: 591 - 597   2017

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    DOI: 10.1016/j.jjcc.2017.03.010

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  113. Cholesterol metabolism as a prognostic marker in patients with mildly symptomatic nonischemic dilated cardiomyopathy Reviewed

    Sawamura Akinori, Okumura Takahiro, Hiraiwa Hiroaki, Aoki Soichiro, Kondo Toru, Ichii Takeo, Furusawa Kenji, Watanabe Naoki, Kano Naoaki, Fukaya Kenji, Morimoto Ryota, Bando Yasuko K., Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 69 ( 5-6 ) page: 888 - 894   2017

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    DOI: 10.1016/j.jjcc.2016.08.012

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  114. Abnormal Circadian Blood Pressure Profile as a Prognostic Marker in Patients with Nonischemic Dilated Cardiomyopathy Reviewed

    Sawamura Akinori, Okumura Takahiro, Takeshita Kyosuke, Watanabe Naoki, Kano Naoaki, Mori Hiroaki, Fukaya Kenji, Morimoto Ryota, Hirashiki Akihiro, Bando Yasuko Kureishi, Murohara Toyoaki

    CARDIOLOGY   Vol. 136 ( 1 ) page: 1 - 9   2017

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    DOI: 10.1159/000446868

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  115. フレイル評価において機能的制限と認知機能低下は高齢急性心不全の予後予測因子となる Reviewed

    7. 清水美帆、渡邊直樹、奥村貴裕、小林聖典、土川洋平、近藤徹、平岩宏章、森本竜太、坂東泰子、山田純生、室原豊明

    心臓リハビリテーション   Vol. 22 ( 4 ) page: 281 - 285   2016

  116. 肺動脈性肺高血圧症におけるエンドセリン受容体拮抗薬による治療初期の変化-生活の質と運動耐容能との関連- Reviewed

    5. 安川悠仁、平敷安希博、服部慶子、鈴木謙太郎、清水美帆、小林聖典、上村佳大、中野嘉久、足立史郎、奥村貴裕、近藤隆久、山田純生、室原豊明

    心臓リハビリテーション   Vol. 21 ( 1 ) page: 42 - 46   2016

  117. 肺動脈性肺高血圧症における運動耐容能に基づく積極的併用療法の検討 Reviewed

    6. 平敷安希博、近藤隆久、清水美帆、小林聖典、上村佳大、中野嘉久、足立史郎、奥村貴裕、山田純生、室原豊明

    心臓リハビリテーション   Vol. 21 ( 4 ) page: 170 - 173   2016

  118. Association between cardiopulmonary exercise and dobutamine stress testing in ambulatory patients with idiopathic dilated cardiomyopathy: A comparison with peak VO(2) and VE/VCO(2) slope. Reviewed

    Okumura T, Hirashiki A, Yamada S, Funahashi H, Ohshima S, Kono Y, Cheng XW, Takeshita K, Murohara T.

    International Journal of Cardiology   Vol. 162 ( 3 ) page: 234 - 239   2013

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  119. Association of cardiorespiratory fitness with characteristics of coronary plaque: Assessment using integrated backscatter intravascular ultrasound and optical coherence tomography. Reviewed

    Yoshikawa D, Ishii H, Kurebayashi N, Sato B, Hayakawa S, Ando H, Hayashi M, Isobe S, Okumura T, Hirashiki A, Takeshita K, Amano T, Uetani T, Yamada S, Murohara T.

    International Journal of Cardiology   Vol. 162 ( 2 ) page: 123 - 128   2013

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    DOI: 10.1016/j.ijcard.2011.05.047

  120. Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy. Reviewed

    Shimazu S, Hirashiki A, Okumura T, Yamada T, Okamoto R, Shinoda N, Takeshita K, Kondo T, Niwa T, Murohara T.

    Circulation Journal     2012

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    DOI: 10.1253/circj.CJ-12-0715

  121. Dipeptidyl Peptidase-4 Modulates Left Ventricular Dysfunction in Chronic Heart Failure via Angiogenesis-Dependent and-Independent Actions. Reviewed

    Shigeta T, Aoyama M, Bando YK, Monji A, Mitsui T, Takatsu M, Cheng XW, Okumura T, Hirashiki A, Nagata K, Murohara T.

    Circulation     page: 1838-51   2012

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  122. Predictive value of functional limitation for disease severity in patients with mild chronic heart failure. Reviewed

    Kono Y, Yamada S, Iwatsu K, Nitobe S, Tanaka Y, Shimizu Y, Shinoda N, Okumura T, Hirashiki A, Murohara T.

    Journal of Cardiology     2012

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    DOI: 10.1016/j.jjcc.2012.07.009.

  123. Predictive value of heart rate recovery after exercise testing in addition to brain natriuretic Peptide levels in ambulatory patients with nonischemic dilated cardiomyopathy. Reviewed

    Shinoda N, Hirashiki A, Okumura T, Okamoto R, Wu Cheng X, Kono Y, Takeshita K, Yamada S, Murohara T.

    Ann Noninvasive Electrocardiol.     2012

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    DOI: 10.1111/j.1542-474X.2012.00542.x.

  124. Association of diabetes mellitus with myocardial collagen accumulation and relaxation impairment in patients with dilated cardiomyopathy. Reviewed

    Sakakibara M, Hirashiki A, Cheng XW, Bando Y, Ohshima K, Okumura T, Funahashi H, Ohshima S, Murohara T.

    Diabetes Res Clin Pract.     page: 348-55   2011

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  125. Impact of mild to moderate renal dysfunction on left ventricular relaxation function and prognosis in ambulatory patients with nonischemic dilated cardiomyopathy. Reviewed

    Ohshima K, Hirashiki A, Cheng XW, Hayashi M, Hayashi D, Okumura T, Sakakibara M, Funahashi H, Ohshima S, Murohara T.

    International Heart Journal     page: 366-71   2011

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  126. 拡張型心筋症における副交感神経活性の検討 Reviewed

    4. 住田佳陽、平敷安希博、奥村貴裕、篠田典宏、河野裕治、諸岡貴子、竹下享典、松本祐之、山田純生、室原豊明

    心臓リハビリテーション   Vol. 16 ( 2 ) page: 197 - 201   2011

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  127. Sotalolが心室頻拍の抑制に有効であったICD装着の2例 Reviewed

    3. 谷村大輔、奥村尚樹、奥村貴裕、舟橋栄人、曽村富士、石原大三、淡路喜史、祖父江俊和、加藤林也、吉田幸彦

    Progress in Medicine   Vol. 26 ( 9 ) page: 283 - 287   2006

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  128. 心外膜起源が疑われた不整脈源性右室心筋症VTの1例 Reviewed

    奥村尚樹、奥村貴裕、谷村大輔、舟橋栄人、曽村富士、石原大三、淡路喜史、祖父江俊和、加藤林也

    THERAPEUTIC RESEARCH   Vol. 27 ( 1 ) page: 87 - 89   2006

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  129. 濃厚な突然死の家族歴を有する高齢発症のARVCの1例 Reviewed

    1. 奥村貴裕・谷村大輔・舟橋栄人・森島幹雄・曽村富士・石原大三・祖父江俊和・加藤林也

    THERAPEUTIC RESEARCH   Vol. 26 ( 2 ) page: 239 - 241   2005

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  130. 心房細動患者における薬物療法の現状 Reviewed

    舟橋栄人、奥村貴裕、谷村大輔、森島幹雄、三橋弘嗣、曽村富士、石原大三、祖父江俊和、棚橋淑文、加藤林也

    THERAPEUTIC RESEARCH   Vol. 25 ( 8 ) page: 1660 - 1661   2004

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▼display all

Books 48

  1. 心血管薬物療法 イバブラジンの薬理を知って心不全治療に活かす

    奥村貴裕

    2022 

  2. 心不全の栄養バイブル ステージC, D; 再入院を防ぐ栄養管理とは?

    奥村貴裕

    中外医学社  2022 

  3. 臨床雑誌 内科 急性心筋炎

    奥村貴裕

    南江堂  2022 

  4. Coronary Intervention 原発性TGCV

    メディアルファ  2021.9 

  5. 月刊薬事 心不全の病態 心不全の病態とメカニズム

    じほう  2021.9 

  6. 拡張型心筋症を臨床的リスクスコアで層別化する

    日本医学出版  2021.8 

  7. Inflammatory cardiomyopathy and chronic myocarditis

    Takahiro Okumura

    2021.5 

  8. 循環器診療コンプリート 心筋症: 心腎脳の視点でとらえる循環器疾患 拡張型心筋症

    ( Role: Contributor)

    秀潤社  2021.3 

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    Language:Japanese Book type:Scholarly book

  9. 臨床循環器学 非薬物治療:内科的治療

    ( Role: Contributor)

    文光堂  2021.3 

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    Language:Japanese Book type:Scholarly book

  10. HEART nursing 秋季増刊 50の?が!に変わる 急性期~慢性期ずっと看るための心不全 完全ガイド 末期心不全の症状とその対応はどうしたらよい?

    奥村貴裕( Role: Contributor)

    メディカ出版  2020.10 

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  11. HEART nursing 秋季増刊 50の?が!に変わる 急性期~慢性期ずっと看るための心不全 完全ガイド 在宅医療ではどんなことをしている?

    奥村貴裕( Role: Contributor)

    メディカ出版  2020.10 

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  12. Heart Nursing ステージC~D:補助人工心臓(心臓移植)適応の患者さんを看る

    奥村貴裕( Role: Contributor)

    メディカ出版  2020.7 

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  13. 治療 プライマリケア医が知っておくべき心不全 検査結果をどうみるか:BNP,NT-proBNP

    奥村貴裕( Role: Contributor)

    南山堂  2020.6 

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  14. Heart View 循環補助と呼吸補助 臨床で有効活用するためのポイントIABPとPCPSはどのように使い分ければよいか?

    奥村貴裕( Role: Contributor)

    メジカルビュー社  2020.4 

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    Language:Japanese Book type:Scholarly book

  15. 血圧 RAAS抑制薬と心不全予防 心不全予防に何をどう使う?

    奥村貴裕, 室原豊明( Role: Contributor)

    先端医学社  2019 

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  16. ナースが知りたい心不全のキホン 慢性心不全の病態とは?

    奥村貴裕, 梅田香織( Role: Contributor)

    メディカ出版  2019 

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  17. 救急・集中治療アドバンス 急性循環不全 心筋保護薬

    奥村貴裕( Role: Sole author)

    中山書店  2019 

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    Language:Japanese

  18. ザ・マニュアル心不全のセット検査 拡張型心筋症様心臓

    奥村貴裕( Role: Contributor)

    メジカルビュー社  2019 

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  19. 心不全ケア教本(第2版)急性心不全の病態生理

    奥村貴裕( Role: Contributor)

    MEDSI  2019 

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  20. 日本臨牀増刊号 心不全(第2版)中 カテコールアミン製剤の使い方

    奥村貴裕( Role: Contributor)

    日本臨牀社  2019 

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  21. 日本臨牀増刊号 心不全(第2版)中 心不全の予後

    奥村貴裕( Role: Contributor)

    日本臨牀社  2019 

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  22. 日本臨牀別冊 循環器症候群(第3版)特発性心筋症

    奥村貴裕( Role: Contributor)

    日本臨牀社  2019 

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  23. 日本臨牀別冊 循環器症候群(第3版)劇症型心筋炎

    奥村貴裕( Role: Contributor)

    日本臨牀社  2019 

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  24. Heart View 循環器疾患+αを考える!他領域疾患併発患者への治療戦略 筋ジストロフィに合併した心筋症

    奥村貴裕( Role: Contributor)

    メジカルビュー社  2019 

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  25. Heart View 診断ツールから読み解く心不全治療 最前線の治療から見えてきたこと-若手循環器医のための若手による企画- 補助人工心臓、心臓移植の現状と展望.

    奥村貴裕( Role: Contributor)

    メジカルビュー社  2019 

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  26. 循環器ジャーナル 薬のギモン-エキスパートに学ぶ薬物治療のテクニック 心不全診療でのギモン 投与中の心筋保護薬 やめたらどうなるの?

    奥村貴裕( Role: Contributor)

    医学書院  2018 

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  27. Heart View 徹底理解・心機能 何をいつ測り、どう活かす? 心機能と予後予測:心機能で可能となる予後予測についてわかっていること

    奥村貴裕( Role: Sole author)

    メジカルビュー社  2018 

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  28. ザ・マニュアル心不全の心カテ 大動脈弁狭窄症

    奥村貴裕( Role: Contributor)

    メジカルビュー社  2018 

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  29. ザ・マニュアル心不全の心カテ 大動脈弁閉鎖不全症

    奥村貴裕( Role: Sole author)

    メジカルビュー社  2018 

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  30. Heart View 増刊号 臨床シナリオに基づく外来診療スキルアップ~こんな外来患者さん、先生ならどうしますか? 特発性拡張型心筋症のセカンドオピニオン

    奥村貴裕( Role: Contributor)

    メジカルビュー社  2018 

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  31. リバースリモデリング~補助人工心臓装着前後の変化 診断モダリティとしての心筋病理

    奥村貴裕( Role: Joint author)

    南江堂  2017 

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  32. 循環器内科 二次性心筋症の臨床 二次性心筋症の心臓移植適応

    奥村貴裕( Role: Contributor)

    科学評論社  2017 

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  33. 循環器ジャーナル 急性心不全治療におけるPDEIII阻害薬の使い方

    奥村貴裕( Role: Contributor)

    医学書院  2017 

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  34. 救急・集中治療 「心不全-その常識は正しいか-」 無症状の左室収縮機能低下例のすべてに,ACE阻害薬,β遮断薬,抗アルドステロン薬の3剤投与は必須か?

    奥村貴裕( Role: Joint author)

    総合医学社  2016 

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  35. 心不全マネジメント2 「右心不全を識り,評価して治療に活かす」 右心カテーテル検査を臨床に活かす

    奥村貴裕、室原豊明( Role: Joint author)

    文光堂  2016 

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  36. これ1冊で完全マスター! ナースがわかる&はなせる心不全まるわか りBOOK ハー トナーシング 2016年 春季増刊 慢性心不全の治療薬:なぜそれが必要なの?正しい服薬指導の第一歩!

    奥村貴裕( Role: Joint author)

    メディカ出版  2016 

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  37. 真っ向勝負の大動脈弁狭窄症・閉鎖不全症 ~6人のエキスパートが全てを語りつくす~

    奥村貴裕( Role: Joint author)

    メディカ出版  2016 

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  38. 診断と治療増刊号 心不全のすべて 特発性拡張型心筋症

    奥村貴裕( Role: Joint author)

    診断と治療社  2015 

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  39. CIRCULATION Up-to-Date Books Vol.7 なぜいま、心不全ですか? 高齢者の心不全になぜ興味をもったのですか?

    奥村貴裕( Role: Joint author)

    メディカ出版  2015 

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  40. CIRCULATION Up-to-Date Books Vol.7 なぜいま、心不全ですか? 強心薬って本当に悪なんでしょうか?

    奥村貴裕( Role: Joint author)

    メディカ出版  2015 

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  41. 新しい診断と治療のABC 心不全 慢性心不全における薬物治療のエビデンス-心不全診療のパラダイムシフト-

    奥村貴裕( Role: Joint author)

    最新医学社  2015 

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  42. ケアネット希少疾患ライブラリ 特発性拡張型心筋症

    奥村貴裕( Role: Sole author)

    ケアネット  2014 

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  43. 敗血症の病態メカニズムと診断薬・新薬開発 臨床現場の敗血症治療のニーズと研究開発 ~各領域で求められる薬剤/診断~ 循環器内科

    奥村貴裕( Role: Joint author)

    技術情報協会  2013 

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  44. 敗血症の病態/メカニズムと診断薬・新薬開発 第8章 各診療科での敗血症治療のアンメットニーズと研究開発. 1-2 循環器内科医

    奥村貴裕( Role: Joint author)

    技術情報協会  2013 

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  45. Cardiomyopathy Contractile reserve in Dialted Cardiomyopathy

    Takahiro Okumura, Toyoaki Murohara( Role: Joint author)

    InTech  2013 

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  46. 神経疾患の循環異常

    奥村貴裕,大橋大器,安間文彦,室原豊明( Role: Joint author)

    医薬ジャーナル社  2012 

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  47. 希少疾患/難病の診断・治療と製品開発

    奥村貴裕,室原豊明( Role: Joint author)

    技術情報協会  2012 

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  48. 急性心不全~重症度・病態に応じた治療戦略の立て方~.主治医として診る救急からの入院治療

    奥村貴裕( Role: Joint author)

    羊土社  2010 

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▼display all

Presentations 49

  1. Derivation and Validation of Machine Learning-based Risk Prediction Model for In-hospital Mortality in Patients with Acute Heart Failure

    Kayo Misumi、Yuya Matsue、Kazutaka Nogi、Taishi Dotare、Tsutomu Sunayama、Daichi Maeda、Nobuyuki Kagiyama、Takeshi Kitai、Shogo Ohishi、Eiichi Akiyama、Satoshi Suzuki、Masayoshi Yamamoto、Keisuke Kida、Takahiro Okumura、Maki Nogi、Satomi Ishihara、Tomoya Ueda、Rika Kawakami、Yoshihiko Saito、Tohru Minamino

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

    Language:English   Presentation type:Poster presentation  

  2. The Prospective Analysis of Prednisolone Therapy in Cardiac Sarcoidosiswith FDG Accumulation in the Heart

    Ryota Morimoto、Kazumasa Unno、Hiroaki Hiraiwa、Toru Kondo、Takahiro Okumura、Satoru Ohshima、Toyoaki Murohara

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

  3. Prognostic Role of B-type Natriuretic Peptide in Patients with Cardiac Sarcoidosis: Insights from ILLUMINATE-CS Invited

    Shota Miyakuni、Kenji Yoshioka、Yuya Matsue、 Taishi Dotare、Tsutomu Sunayama、Daichi Maeda、 Takeru Nabeta、Yoshihisa Naruse、Takeshi Kitai、 Tatsunori Taniguchi、Hidekazu Tanaka、Takahiro Okumura、Yuichi Baba、Akihiko Matsumura、Tohru Minamino

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

  4. Mild Impairment of Left Ventricular Ejection Fraction is Associated with Ventricular Arrhythmic Events in Cardiac Sarcoidosis : Insights from ILLUMINATE-CS

    Yuka Akama、Yuya Matsue、Daichi Maeda、Taishi Dotare、Tsutomu Sunayama、Kenji Yoshioka、Takeshi Kitai、Yoshihisa Naruse、Tatsunori Taniguchi、Hidekazu Tanaka、Takahiro Okumura、Yuichi Baba、Takeru Nabeta、Tohru Minamino

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  5. Relationship between Impella 5.0 Duration Period and Purge System Malfunction Invited

    大石英生、森本竜太、伊藤亮太、風間信吾、木村祐樹、荒木孝、水谷崇、桒山輔、平岩宏章、近藤徹、奥村貴裕、室原豊明

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Poster presentation  

  6. Clinical Impact of Visually Assessed Right Ventricular Dysfunction in Patients with Septic Shock Invited

    平岩宏章、春日井大介、伊藤亮太、荒木孝、水谷崇、風間信吾、木村祐樹、大石英生、桒山輔、 近藤徹、古澤健司、森本竜太、奥村貴裕、室原豊明

    第86回日本循環器学会学術集会   2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  7. Prognostic Value of 123I-Metaiodobenzylguanide Scintigraphy in Patients with Non Ischemic Dilated Cardiomyopathy Invited

    水谷崇、森本竜太、奥村貴裕、風間信吾、木村祐樹、荒木孝、大石英生、桒山輔、平岩宏章、室原豊明

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Poster presentation  

  8. Update on the Management of Acute and Fulminant Myocarditis in 2022 Invited

    Takahiro Okumura, Yuki Kimura, Toyoaki Murohara

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  9. Type D personality and Prognosis in Hospitalized Heart Failure Patients

    Takahiro Okumura, Hiroaki Hiraiwa, Yuki Kimura, Ryota Ito, Takashi Araki, Takashi Mizutani, Shingo Kazama, Hideo Oishi, Tasuku Kuwayama, Toru Kondo, Ryota Morimoto, Toyoaki Murohara

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

  10. Team-based Comprehensive Cardiac Rehabilitation in the Acute Phase of Intensive Care in Patients with Advanced Heart Failure Invited

    Takahiro Okumura, Miho Shimizu, Harumi Takeuchi, Tasuku Kuwayama, Hiroaki Hiraiwa, Ryota Morimoto, Kiyonori Kobayashi, Toyoaki Murohara

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  11. ⼼筋炎をチームで診る︕心筋炎と心筋症 重症心不全のマネジメント Invited

    奥村貴裕

    ARIA 2021 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  12. Pros Cons ECMO+IABP is better than ECMO+IMPELLA Invited

    第25回日本心不全学会学術集会  2021.10 

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    Event date: 2021.10

    Presentation type:Symposium, workshop panel (nominated)  

  13. シンポジウム ARNIのエビデンスとガイドライン:現状と残された課題 Invited

    第25回日本心不全学会学術集会  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  14. Pros Cons 高齢者への侵襲的治療選択では、エビデンスに基づいた医療(EBM)を重視すべき! Invited

    第25回日本心不全学会学術集会  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  15. Clinical significance of spleen size in patients with heart failure

    Hiroaki Hiraiwa, Takahiro Okumura, Toru Kondo, Ryota Ito, Takashi Araki, Takashi Mizutani, Shingo Kazama, Yuki Kimura, Hideo Oishi, Kenji Furusawa, Ryota Morimoto, Toyoaki Murohara

    2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  16. Multicenter retrospective registry of cardiac sarcoidosis in Japan: a preliminary report from ILLUMINATE-CS.

    Nabeta Takeru, Naruse Yoshihisa, Taniguchi Tatsunori, Kitai Takeshi, Yoshioka Kenji, Tanaka Hidekazu, Okumura Takahiro, Baba Yuichi, Kida Keisuke, Tamaki Yodo, Sato Kimi, Kitano Daisuke, Matsumoto Shingo, Toma Yuichiro, Watanabe Naok, Miyajima Keisuke, Fukunaga Masato, Saito Hideki, Sato Hiroyuki, Kikuchi Atsushi, Ishihara Satomi, Okabe Toshitaka, Suzuki-Oyama Kyoko, Hidaka Takayuki, Yamaguchi Tetsuo, Abe Masami, Kato Shingo, Ise Takayuki, Tamura Yuichi, Ishida Miwa, Matsue Yuya

    第25回日本心不全学会学術集会  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  17. ワークショップ 心臓移植において悪性腫瘍は一律に適応除外とされるべきか? Invited

    第57回日本移植学会総会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  18. Serum autotaxin level predicts future cardiac events in patients with dilated cardiomyopathy International conference

    Araki T, Okumura T, Mizutani T, Kimura Y, Kazama S, Shibata N, Oishi H, Kuwayama T, Hiraiwa H, Kondo T, Morimoto R, Takefuji M, Murohara T

    ESC Congress 2021  2021.8 

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    Event date: 2021.8

    Language:English   Presentation type:Poster presentation  

  19. CPA蘇生後に肺動脈血からの細胞診にて診断を得た肺動脈腫瘍塞栓微小血管症の一例

    風間信吾、森本竜太、木村祐樹、柴田直紀、大石英生、荒木孝、水谷崇、桒山輔、平岩宏章、近藤徹、中野嘉久、足立史郎、奥村貴裕、近藤隆久、室原豊明

    第157回日本循環器学会東海地方会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  20. 抗リウマチ薬再投与後に心臓内びまん性大細胞型B細胞リンパ腫を発症した一例

    森本竜太、水谷崇、荒木孝、木村祐樹、風間信吾、柴田直紀、大石英生、桒山輔、平岩宏章、近藤徹、奥村貴裕、因田恭也、室原豊明

    第157回日本循環器学会東海地方会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  21. 腎癌に伴う動静脈瘻により高拍出性心不全を呈した一例

    戸部彰洋、田中哲人、吉田聡哉、近藤徹、森本竜太、古澤健司、奥村貴裕、坂東泰子、石井秀樹、室原豊明

    第157回日本循環器学会東海地方会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  22. 当院におけるHER2陽性乳癌に対するトラスツマブ使用とがん治療関連心合併症に関して

    尾崎令奈、森本竜太、坂東泰子、風間信吾、渡邊諒、平岩宏章、近藤徹、古澤健司、奥村貴裕、室原豊明

    第157回日本循環器学会東海地方会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  23. 心不全随伴症状を心臓リハビリテーションで改善させる Invited

    ‌‌奥村貴裕

    第27回日本心臓リハビリテーション学会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  24. LVAD患者における退院時下肢筋力と再入院との関連性

    ‌‌小林聖典,奥村貴裕,平岩宏章,近藤徹,森本竜太,六鹿雅登,堀将也,高木大地,碓氷章彦,室原豊明

    第27回日本心臓リハビリテーション学会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  25. 地域在住高齢者における心肺運動負荷試験と超音波検査による運動時循環応答評価 Invited

    野田明子,中嶋穂乃佳,柴田洋綺,伊藤温喜,奥村貴裕

    第27回日本心臓リハビリテーション学会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  26. MIBG心筋シンチグラフィによる特発性拡張型心筋症のリスク評価への有用性について Invited

    水谷崇、森本竜太、風間信吾、木村祐樹、大石英生、荒木孝、桒山輔、平岩宏章、近藤徹、奥村貴裕、室原豊明

    第157回日本循環器学会東海地方会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  27. 覚醒下ECPELLAにて、救命し得たパルボウイルスB19劇症型心筋炎の一例 Invited

    荒木孝、奥村貴裕、水谷崇、木村祐樹、風間信吾、大石英生、桒山輔、平岩宏章、近藤徹、森本竜太、室原豊明

    第157回日本循環器学会東海地方会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  28. 拡張型心筋症患者におけるリバースリモデリング予測スコア Invited

    木村祐樹,奥村貴裕,森本竜太,風間信吾,柴田直紀,大石英生,荒木孝,水谷崇,桒山輔,平岩宏章,近藤徹,室原豊明

    第7回日本心筋症研究会  2021.4 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Poster presentation  

  29. 拡張型心筋症における新規予後マーカーとしての血清オートタキシン Invited

    荒木孝,奥村貴裕,水谷崇,木村祐樹,風間信吾,柴田直紀,大石英生,桒山 輔,近藤徹,森本竜太,竹藤幹人,室原豊明

    第7回日本心筋症研究会   2021.4 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (general)  

  30. 抗ミトコンドリア M2 抗体陽性を呈した心筋症についての検討

    風間信吾,近藤徹,木村祐樹,柴田直紀,大石英生,荒木孝,水谷崇,桒山輔,平岩宏章,森本竜太,奥村貴裕,室原豊明

    第7回日本心筋症研究会  2021.4 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Poster presentation  

  31. シンポジウム 心筋炎の病理と薬物治療戦略 Invited

    奥村貴裕,木村祐樹,桒山輔,平岩宏章,近藤徹,森本竜太,伊藤英樹,六鹿雅登,碓氷章彦,室原豊明

    第7回日本心筋症研究会  2021.4 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  32. シンポジウム 急性心筋炎・劇症型心筋炎 Invited

    奥村貴裕,木村祐樹,桒山輔,平岩宏章,近藤徹,森本竜太,伊藤英樹,六鹿雅登,碓氷章彦,室原豊明

    第7回日本心筋症研究会  2021.4 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  33. Prolonged Inflammation in Myocardium: Transition from Acute Myocarditis to Chronic Myocarditis Invited

    Takahiro Okumura, Yuki Kimura, Toyoaki Murohara

    第85回日本循環器学会学術集会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  34. Association between Cardiac Troponin T Level and Myocardial Recovery in Fulminant Myocarditis

    近藤徹、柴田直紀、風間信吾、木村祐樹、大石英生、桒山輔、平岩宏章、森本竜太、奥村貴裕、 室原豊明

    第85回日本循環器学会学術集会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  35. The Relationship between Serum Adiponectin Level and Functional Status after In-hospital Cardiac Rehabilitation in Elderly Patients with Heart Failure

    安藤圭、堀部秀樹、前川泰孝、田中雄己、山瀬裕一郎、舟曵純哉、上山力、竹本芳雄、重田寿正、日比野剛、近藤泰三、奥村貴裕、室原豊明

    第85回日本循環器学会学術集会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  36. 重症心不全に対する補助循環装置の使い分け~VA ECMO, IABP, Impella~ Invited

    奥村貴裕

    第48回日本救急医学会総会・学術集会  2020.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  37. Comparison Between Impella 5.0 and External Corporeal Left Ventricular Assist Device as a Bridge to Decision in Patients with Cardiogenic Shock International conference

    Kondo T, Shibata N, Kazama S, Kimura Y, Oishi H, Kuwayama T, Morimoto R, Okumura T, Murohara T

    American Heart Association (AHA) Scientific Sessions 2020  2020.11 

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    Event date: 2020.11

    Language:English   Presentation type:Poster presentation  

  38. Cardiac Troponin T Level Is Associated With Myocardial Recovery In Fulminant Myocarditis International conference

    Kondo T, Shibata N, Kazama S, Kimura Y, Oishi H, Kuwayama T, Hiraiwa H, Morimoto R, Okumura T, Murohara T

    American Heart Association (AHA) Scientific Sessions 2020  2020.11 

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    Event date: 2020.11

    Language:English   Presentation type:Poster presentation  

  39. Clinical Impact of Heart Rate Change in Early Phase in Patients With Acute Decompensated Heart Failure International conference

    Kazama S, Kondo T, Kimura Y, Shibata N, Oishi H, Araki T, Mizutani T, Kuwayama T, Hiraiwa H, Morimoto R, Okumura T, Sawamura A, Shimizu K, Kato T, Murohara T

    American Heart Association (AHA) Scientific Sessions 2020  2020.11 

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    Event date: 2020.11

    Language:English   Presentation type:Poster presentation  

  40. The Prognostic Impact of Transcardiac Gradient of Follistatin-like 1 In Patients With Non-ischemic Dilated Cardiomyopathy International conference

    Oishi H, Okumura T, Ohashi K, Kimura Y, Kazama S, Shibata N, Arao Y, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Hiraiwa H, Morimoto R, Ouchi N, Murohara T

    American Heart Association (AHA) Scientific Sessions 2020  2020.11 

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    Event date: 2020.11

    Language:English   Presentation type:Poster presentation  

  41. The Prognostic Impact of Human Epididymis Protein 4 Levels in Patients With Dilated Cardiomyopathy International conference

    Okumura T, Oishi H, Araki T, Mizutani T, Kazama S, Shibata N, Kuwayama T, Hiraiwa H, Kondo T, Morimoto R, Takefuji M, Murohara T

    American Heart Association (AHA) Scientific Sessions 2020  2020.11 

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    Event date: 2020.11

    Language:English   Presentation type:Poster presentation  

  42. 劇症型心筋炎を学ぶ:その症状、本当に風邪ですか? Invited

    奥村貴裕

    第156東海・第141回北陸合同地方会  2020.10 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  43. シンポジウム 基礎と臨床の両側面からClinical Questionを紐解く 拡張型心筋症におけるリバースリモデリングを実臨床でどう予測するか? Invited

    木村祐樹,奥村貴裕,森本竜太,風間信吾,柴田直紀,大石英生,荒木孝,水谷崇,桒山輔,平岩宏章,近藤徹,室原豊明

    第24回日本心不全学会学術集会  2020.10 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  44. シンポジウム 心筋症の鑑別 心臓サルコイドーシスを鑑別する Invited

    奥村貴裕,森本竜太,荒木孝,水谷崇,木村祐樹,風間信吾,柴田直紀,大石英生,桒山輔,平岩宏章,近藤徹,室原豊明

    第24回日本心不全学会学術集会  2020.10 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  45. シンポジウム コメディカル向け-治療ができる心筋症 心臓サルコイドーシス治療介入研究-プレドニン不応性に対するメソトレキサートの有効性についての検討 Invited

    森本竜太,荒木孝,水谷崇,木村祐樹,風間信吾,柴田直紀,大石英生,桒山輔,平岩宏章,近藤徹,奥村貴裕,室原豊明

    第24回日本心不全学会学術集会  2020.10 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  46. 急性心不全セッション 徹底討論「急性期臓器保護をどう考えるべきか?」心不全急性期の臓器保護は必要か? Invited

    奥村貴裕,荒木孝,水谷崇,木村祐樹,風間信吾,柴田直紀,大石英生,桒山輔,平岩宏章,近藤徹,森本竜太,室原豊明

    第24回日本心不全学会学術集会  2020.10 

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    Event date: 2020.10

  47. 植込型補助人工心臓装着患者に対するICTを活用した多職種連携患者支援について Invited

    河野紀子、倉知茜、矢野亨治、池本千春、竹内晴美、後藤和大、長谷川静香、六鹿雅登、奥村貴裕、近藤徹、室原豊明、笹山哲、野本愼一

    第24回日本心不全学会学術集会  2020.10 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  48. 心不全診療のチェンジプラクティス Combined Exercise and Nutritional Interventions are the Keys for the Management of Heart Failure. Invited

    奥村貴裕

    第84回日本循環器学会学術集会  2020.7 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  49. 心不全治療薬を基礎から知ろう~処方医のアタマのなかをのぞき見るための薬効講義~ Invited

    奥村貴裕

    第26回日本心臓リハビリテーション学会  2020.7 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 1

  1. 心臓カヘキシーにおける心‐腸‐肝連関の解析と評価のための新規マーカーの探索

    2018.3 - 2019.3

    公益財団法人 鈴木謙三記念医科学応用研究財団 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 劇症型心筋炎における急性期管理法の確立および低侵襲早期診断マーカーの探索と開発

    Grant number:21K08025  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    奥村 貴裕, 今中恭子, 竹藤 幹人, 鈴木 忠樹, 室原 豊明

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    急性心筋炎の初期症状は非特異的であり、早期診断に有用なツールも未確立のため、診断に難渋することが多い。しかし重篤度は高く、ときに劇症型とよばれる急激かつ致死的な経過をとる。本研究では、全国多施設で急性心筋炎の前向きレジストリを構築し、病理学的に診断された急性心筋炎症例の診療現状を検証する。心筋検体を用いて心筋炎の病理学的特徴を明らかにし、治療介入と検査データの経過、予後との関連を検証することで、適切な急性期管理法を確立する。①初期診断に有用な生体マーカーを探索し、将来的な早期診断キット開発の基盤とすること、②急性期管理における適切な管理法や機械的循環補助の移行基準、エビデンスの創出をめざす。

  2. 中性脂肪蓄積心筋血管症の診療体制の構築

    Grant number:20317163  2020.4 - 2022.3

    厚生労働科学研究費補助金 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\130000 ( Direct Cost: \100000 、 Indirect Cost:\30000 )

  3. 拡張型心筋症における慢性炎症の病態メカニズムの解明と層別化

    Grant number:19H03442  2019.4 - 2022.3

    科学研究費助成事業  基盤研究(B)

    今中恭子, 植田 初江, 田尻 和子, 奥村 貴裕, 廣江 道昭, 宇都 健太, 俵 功, 鈴木 忠樹, 長谷川 秀樹

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\130000 ( Direct Cost: \100000 、 Indirect Cost:\30000 )

    拡張型心筋症(dilated cardiomyopathy: DCM)は様々な病因・病態の混合した疾患群の総称であり、慢性心筋炎は主要な原因の一つと考えられてきた。そのような症例は他のDCMと異なり免疫抑制療法による心不全進行抑制が期待されるが、現在、診断・治療指針はない。さらに、炎症細胞浸潤を伴う炎症性拡張型心筋症(inflammatory DCM: iDCM)という疾患群が提唱されるようになったが、慢性心筋炎と概念が混乱している。本研究では、慢性心筋炎の心筋生検組織を解析し、動物モデル実験による病態メカニズムの解明と並行しながら疾患概念を整理し、最適な治療法選択のための診断法確立を目指す。
    拡張型心筋症(dilated cardiomyopathy: DCM)は様々な病因・病態の混合した疾患群の総称であり、一部は心筋炎から移行すると考えられてきた。心筋炎は、一般にウイルス感染に起因する自己免疫反応による一過性疾患と理解されるが、一部の症例では炎症が持続し慢性化する。慢性心筋炎は、急性心筋炎として発症し炎症が持続する遷延性慢性心筋炎と、気づかないうちに急性心筋炎から移行し進行性の重症心不全をきたす不顕性慢性心筋炎の2つに分けられるが、いずれも他のDCMと異なり、積極的な免疫抑制療法による心不全進行抑制が期待される。現在の唯一の診断法は心筋生検による病理組織診断であるが、統一した客観的診断基準はなく、病態メカニズムも不明である。さらに最近、炎症細胞浸潤を伴う炎症性拡張型心筋症(inflammatory DCM: iDCM)という疾患群が提唱されるようになったが、慢性心筋炎と概念・用語が混乱している。本研究では、ヒト急性・慢性心筋炎の心筋生検標本を解析して、動物モデル実験による病態メカニズムの解明と並行しながら疾患概念を整理、組織診断基準を策定し、最適な治療法選択のための診断法の確立を目指す。
    そのために
    ①慢性心筋炎のレジストリーを全国レベルで構築して心筋生検標本を解析し、浸潤細胞のプロファイル、組織炎症マーカー染色を併用した組織診断基準を確立する。
    ②①に従って慢性心筋炎と診断した症例の組織・血液検体の集学的解析を行い、ヒト心筋炎慢性化のメカニズムを解明する。
    ③慢性心筋炎マウスモデルを樹立して、病態を免疫学的、分子生物学的に詳細に解析し①、②の理論的裏付けとする。
    1. 慢性心筋炎を受診時の臨床像により、拡張型心筋症の中に混じった潜在性慢性心筋炎 <Multicenter Registry to Investigate Inflammatory Cell Infiltration in Dilated Cardiomyopathy in Tissues of Endomyocardial Biopsy-2: <INDICATE-2>と急性心筋炎から遷延する慢性心筋炎<Multicenter obsERvational prospeCtive stUdy of biopsy-pRoven acute mYocarditis、MERCURY>の2つに分けてレジストリを構築するために倫理委員会の承認を得て症例登録を開始した。
    2.  <INDICATE-2>の予備解析を行い、2013年にヨーロッパ心臓病学会から提唱された複数の免疫染色を組み合わせた炎症評価基準及び治療指針に基づくと、と日本の拡張型心筋症患者の48%が炎症性拡張型心筋症として免疫抑制剤投与対象となってしまい日本の慢性心筋炎の考え方と大きく異なることが明らかになり、Tリンパ球の浸潤評価に基づく独自の基準の有用性の評価を行なっている。
    3.心筋ミオシンペプチド(MyHCα)とComplete Freund's adjuvant(CFA)をマウスに投与するも一過性急性自己免疫性モデルを作成し、浸潤細胞のプロファイルの急性炎症期、炎症消褪期、瘢痕形成期の経時的変化の解析を行っている。
    1.2つのレジストリによる心筋生検組織検体の解析を行なって、臨床像と対比し、我々の組織診断基準の有用性を検証する。また、免疫抑制治療剤を投与するか決定するための重要な因子であるウイルス感染の有無が十分に行われていなかったため、現在構築中の網羅的ウイルス検索システムにより解析し、日本の慢性心筋炎におけるウイルス感染の実態を明らかにする。
    2.昨年度に引き続き、心筋ミオシンペプチド(MyHCα)とComplete Freund's adjuvant(CFA)モデルマウスで各時相のsignature molecule/cellの同定と、心筋ミオシンエピトープ遺伝子を組み込んだ組換えBCG(rBCG-MyHCα)による慢性心筋炎モデルのcharacterizationを行う。さらに、テネイシンC過剰発現マウスを用いた慢性心筋炎モデルの作成を試みる。

  4. 心筋疾患におけるマイオカインの病態生理学的意義解明と治療応用のための基盤研究

    Grant number:19K17592  2019.4 - 2022.3

    科学研究費助成事業  若手研究

    奥村 貴裕

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    心筋疾患では、心筋細胞肥大や間質の線維化といった心臓の組織学的および構造的変化(リモデリング)を伴う。近年、骨格筋がFSTL-1やマイオネクチン、FGF-21などの生理活性物質(マイオカイン)を産生することが報告された。動物モデルを用いた最近の研究により、マイオカインが細胞死抑制作用や抗炎症作用を介して心臓保護的に働くことが明らかとなった。申請者は、血中マイオカイン濃度が心筋疾患における心負荷・心不全重症度を反映し、リモデリングに関与するとの仮説を立てた。このため本研究では、ヒト検体でのマイオカイン血中濃度を測定し、血行動態や心不全重症度、心リモデリング、予後との関連を検討する。
    Follistatin-like 1(FSTL-1)は、細胞死抑制作用や抗炎症作用を介して心臓保護的に働くことが示されている。一方、オートタキシン(ATX)は、リゾホスファチジン酸(LPA)の生成を通じて、心筋の炎症とそれに続く心臓のリモデリングを促進することが報告されている。研究代表者らは、拡張型心筋症(DCM)患者104名(49.8歳、男性76人)における血清ATX濃度と予後との関連を検討した。血清ATXレベルには性差が報告されているため、男性・女性それぞれの血清ATXレベルの中央値を使用して、被験者を2つの群(高ATX群と低ATX群)に分類した。心不全悪化による入院と心臓死の複合イベントを主要アウトカムと定義した。被験者の89%は、NYHA心機能分類IまたはII度であった。女性患者の血清ATXレベルは男性患者よりも高値であった。左室駆出率および脳性ナトリウム利尿ペプチドレベルは、それぞれ平均30.6%、122.5pg/mLあった。生存分析では、累積イベント回避率は高ATX群で有意に低かった。コックス比例ハザード分析では、High-ATXは複合心臓イベントの独立した予測因子の1つであった。一方、血清ATX濃度は、心筋組織における線維化率や高感度C反応蛋白レベルとの相関は認めなかった。本研究の成果は、NYHA心機能分類の低い軽症な心不全症状を有するDCM患者においても、血清ATX濃度が予後層別化に有用な可能性があり、DCMの早期治療におけるマーカーあるいはターゲットとなる可能性が示唆された。
    研究代表者らはこれまでに、細胞死抑制作用や抗炎症作用を介して心臓保護的に働くFSTL-1に着目し、DCM患者における血中FSTL-1の経心臓濃度差と心イベントとの関連を示した。今回、心筋の炎症とそれに続く心臓のリモデリングのマーカーとしてのATXに着目し、血中ATX濃度と心イベントとの関連を示した。このため、本研究課題の進捗はおおむね順調に進行していると考えるが、成果の公表とさらなる課題の追求のため、1年の研究期間延長を行った。
    研究代表者らは、これまでDCM患者における経心臓FSTL-1濃度差と臨床予後との関連を示した。また、生体の炎症を反映する高ATX濃度がDCM患者の不良な予後と関連していることを示した。さらなる症例数の確保を進め、成果を纏めたのち、学会発表や論文等で公表する。

  5. Pathophysiological significance of the Klotho-FGF system in myocardial diseases

    Grant number:16K09429  2016.4 - 2020.3

    Okumura Takahiro

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    We examined the relationship between serum FGF-23 levels and biomarkers, hemodynamics, and prognosis in 42 patients with dilated cardiomyopathy. FGF-23 levels in peripheral vein was negatively correlated with estimated glomerular filtration rate and positively with high-sensitivity troponin T levels. In survival analysis, the cardiac event rate was significantly higher in the High FGF-23 group than in the Low FGF-23 group. In multivariate analysis, the high FGF-23 group was an independent predictor of cardiac events. In multiple regression analysis, the estimated glomerular filtration rate and brain natriuretic peptide levels were significant determinants of FGF-23 levels. Collagen volume fraction in endomyocardial biopsy samples was not significantly correlated with peripheral FGF-23 levels, but was weakly correlated with the transcardiac gradient of FGF-23 levels defined as the difference in concentration between the coronary sinus and the base of the aorta.

  6. 拡張型心筋症におけるカテプシンKの病態生理学的意義解明と新規治療への応用

    Grant number:25860594  2013.4 - 2016.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

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Teaching Experience (On-campus) 46

  1. 医学部学生 臨床実習(ポリクリⅡ)

    2021

  2. 医学部学生 臨床実習(ポリクリⅠ)

    2021

  3. 医学部学生 内科学系統講義(心不全)

    2021

  4. 医学部学生 選択特別講義(循環器領域の先進医療)

    2021

  5. 医学部学生 臨床実習(ポリクリⅠ)

    2020

  6. 医学部学生 内科学系統講義(心不全)

    2020

  7. 医学部学生 選択特別講義(循環器領域の先進医療)

    2020

  8. 内科学学士試験問題作成 (循環器内科)

    2020

  9. 医学部学生 基本的技能実習(心電図)

    2020

  10. 医学部学生 臨床実習(ポリクリⅡ)

    2020

  11. 医学部学生 臨床実習(ポリクリⅠ)

    2019

  12. 医学部学生 内科学系統講義(心不全)

    2019

  13. 病院職員対象 ICLS講習

    2019

  14. 内科学学士試験問題作成 (循環器内科)

    2019

  15. 医学部学生 基本的技能実習(心電図)

    2019

  16. 医学部学生 臨床実習(ポリクリⅡ)

    2019

  17. 医学部学生 臨床実習(ポリクリⅠ)

    2018

  18. 医学部学生 内科学系統講義(心不全)

    2018

  19. 病院職員対象 ICLS講習

    2018

  20. 内科学学士試験問題作成 (循環器内科)

    2018

  21. PBLチュートリアル

    2018

  22. 医学部学生 基本的技能実習(心電図)

    2018

  23. 医学部学生 臨床実習(ポリクリⅡ)

    2018

  24. 医学部学生 基本的技能実習(心電図)

    2017

  25. 医学部学生 内科学系統講義(心不全)

    2017

  26. 医学部学生 臨床実習(ポリクリⅡ)

    2017

  27. 病院職員対象 ICLS講習

    2017

  28. 内科学学士試験問題作成 (循環器内科)

    2017

  29. PBLチュートリアル

    2017

  30. 医学部学生 臨床実習(ポリクリⅠ)

    2017

  31. 医学部学生 臨床実習(ポリクリⅡ)

    2016

  32. 医学部学生 基本的技能実習(心電図)

    2016

  33. 医学部学生 内科学系統講義(心不全)

    2016

  34. 内科学学士試験問題作成 (循環器内科)

    2016

  35. 医学部学生 臨床実習(ポリクリⅠ)

    2016

  36. 医学部学生 基本的技能実習(心電図)

    2015

  37. 医学部学生 内科学系統講義(心不全)

    2015

  38. 内科学学士試験問題作成 (循環器内科)

    2015

  39. 医学部学生 臨床実習(ポリクリⅠ)

    2015

  40. 医学部学生 臨床実習(ポリクリⅡ)

    2015

  41. 内科学学士試験問題作成 (循環器内科)

    2014

  42. 医学部学生 内科学系統講義(心不全)

    2014

  43. 医学部学生 臨床実習(ポリクリⅠ)

    2014

  44. 医学部学生 臨床実習(ポリクリⅡ)

    2014

  45. 医学部学生 臨床実習(ポリクリⅠ)

    2013

  46. 医学部学生 臨床実習(ポリクリⅠ)

    2012

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Teaching Experience (Off-campus) 10

  1. アップグレードセミナー 急性そして劇症型心筋炎の病態と治療

    2022.3

  2. 日本心不全学会 チーム医療推進委員会教育セミナー(応用編)

    2021.8

  3. 第27回日本心臓リハビリテーション学会 教育講座

    2021.6

  4. 日本心不全学会 チーム医療推進委員会教育セミナー(基礎編)

    2021.5

  5. 第156東海・第141回北陸合同地方会 教育セッション

    2020.10

  6. 第26回日本心臓リハビリテーション学会 基本教育講座

    2020.7

  7. 名城大学薬学部 卒後教育講座

    2019.5

  8. 日本心不全学会 教育研修委員会 心不全教育セミナー

    2018.10

  9. 日本心不全学会 チーム医療推進委員会 教育セミナー

    2016.4

  10. 名古屋掖済会病院 新研修医対象 ICLS講習

    2003.4

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Social Contribution 1

  1. 移植医療 メディカルコンサルタント

    Role(s):Advisor

    2017

Media Coverage 1

  1. 紙上診察室 拡張型心筋症 Newspaper, magazine

    中日新聞  2020.10

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    Author:Myself 

Academic Activities 1

  1. 日本循環器学会学術集会 抄録査読

    Role(s):Peer review

    2015

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    Type:Peer review