Organization
Nagoya University Hospital Nephrology Lecturer of hospital
Title
Lecturer of hospital
SAITO Shoji
Degree 1
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博士（医学） （ 2011.1 名古屋大学 ）
Research Areas 1
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Life Science / Nephrology
Education 2
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Nagoya University Graduate School, Division of Medical Sciences
- 2011.1
Country： Japan
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Nagoya City University Faculty of Medicine
- 2001.3
Country： Japan
Professional Memberships 4
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日本内科学会
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日本腎臓学会
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日本透析医学会
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臨床腎移植学会
Papers 11
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A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts
Minatoguchi Shun, Saito Shoji, Furuhashi Kazuhiro, Sawa Yuriko, Okazaki Masaki, Shimamura Yuko, Kaihan Ahmad Baseer, Hashimoto Yusaku, Yasuda Yoshinari, Hara Akitoshi, Mizutani Yasuyuki, Ando Ryota, Kato Noritoshi, Ishimoto Takuji, Tsuboi Naotake, Esaki Nobutoshi, Matsuyama Makoto, Shiraki Yukihiro, Kobayashi Hiroki, Asai Naoya, Enomoto Atsushi, Maruyama Shoichi
SCIENTIFIC REPORTS Vol. 12 ( 1 ) page： 5389 2022.3
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A digest of the Evidence-Based Clinical Practice Guideline for Nephrotic Syndrome 2020
Wada Takehiko, Ishimoto Takuji, Nakaya Izaya, Kawaguchi Takehiko, Sofue Tadashi, Shimizu Sayaka, Kurita Noriaki, Sasaki Sho, Nishiwaki Hiroki, Koizumi Masahiro, Saito Shoji, Nishibori Nobuhiro, Oe Yuji, Yoshida Mai, Miyaoka Yoshitaka, Akiyama Shin'ichi, Itano Yuya, Okazaki Masaki, Ozeki Takaya, Ichikawa Daisuke, Oguchi Hideyo, Kohsaka Satoshi, Kosaka Shiho, Kataoka Yuki, Shima Hideaki, Shirai Sayuri, Sugiyama Kazuhiro, Suzuki Tomo, Son Daisuke, Tanaka Tomomi, Nango Eishu, Niihata Kakuya, Nishijima Yoko, Nozu Kandai, Hasegawa Midori, Miyata Rei, Yazawa Masahiko, Yamamoto Yoshihiro, Yamamoto Ryohei, Shibagaki Yugo, Furuichi Kengo, Okada Hirokazu, Narita Ichiei
CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 25 ( 12 ) page： 1277 - 1285 2021.12
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Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis.
Ryuge A, Kim H, Suzuki Y, Okazaki M, Kojima H, Saito S, Kato N, Ishimoto T, Kosugi T, Maruyama S, Mizuno M
Internal medicine (Tokyo, Japan) 2021.2
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Efficacy of favipiravir for an end stage renal disease patient on maintenance hemodialysis infected with novel coronavirus disease 2019
Koshi Eri, Saito Shoji, Okazaki Masaki, Toyama Yuki, Ishimoto Takuji, Kosugi Tomoki, Hiraiwa Hiroaki, Jingushi Naruhiro, Yamamoto Takanori, Ozaki Masayuki, Goto Yukari, Numaguchi Atsushi, Miyagawa Yasuhiro, Kato Io, Tetsuka Nobuyuki, Yagi Tetsuya, Maruyama Shoichi
CEN CASE REPORTS Vol. 10 ( 1 ) page： 126 - 131 2021.2
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Acquired Fanconi Syndrome in a Patient with Nontyphoidal Salmonella Bacteremia
Ryuge Akihiro, Saito Shoji, Morioka Hiroshi, Hachiya Asaka, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi
INTERNAL MEDICINE Vol. 60 ( 5 ) page： 761 - 764 2021
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Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors
Sakurai Yasutaka, Ichinoe Masaaki, Yoshida Kazuki, Nakazato Yuka, Saito Shoji, Satoh Masashi, Nakada Norihiro, Sanoyama Itaru, Umezawa Atsuko, Numata Yoshiko, Jiang Shi-Xu, Ichihara Masatoshi, Takahashi Masahide, Murakumo Yoshiki
CANCER LETTERS Vol. 489 page： 100 - 110 2020.10
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Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia
Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko
INTERNAL MEDICINE Vol. 59 ( 5 ) page： 683 - 687 2020
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Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction
Hara Akitoshi, Kobayashi Hiroki, Asai Naoya, Saito Shigeyoshi, Higuchi Takahiro, Kato Katsuhiro, Okumura Takahiro, Bando Yasuko K., Takefuji Mikito, Mizutani Yasuyuki, Miyai Yuki, Saito Shoji, Maruyama Shoichi, Maeda Keiko, Ouchi Noriyuki, Nagasaka Arata, Miyata Takaki, Mii Shinji, Kioka Noriyuki, Worthley Daniel L., Murohara Toyoaki, Takahashi Masahide, Enomoto Atsushi
CIRCULATION RESEARCH Vol. 125 ( 4 ) page： 414 - 430 2019.8
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Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study
Katsuno Takayuki, Masuda Tomohiro, Saito Shoji, Kato Noritoshi, Ishimoto Takuji, Kato Sawako, Kosugi Tomoki, Tsuboi Naotake, Kitamura Hiroshi, Tsuzuki Toyonori, Ito Yasuhiko, Maruyama Shoichi
CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 23 ( 2 ) page： 207-214 2019.2
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High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis.
Xu X, Tan X, Tampe B, Wilhelmi T, Hulshoff MS, Saito S, Moser T, Kalluri R, Hasenfuss G, Zeisberg EM, Zeisberg M
Nature communications Vol. 9 ( 1 ) page： 3509 2018.8
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A CASE OF RAPIDLY PROGRESSIVE NEPHRITIC SYNDROME AND NEPHROTIC SYNDROME DURING THE TREATMENT OF DERMATOMYOSITIS AND DIABETES
Sato Naokazu, Katsuno Takayuki, Mori Masayoshi, Saito Shouji, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Ito Yasuhiko, Maruyama Shouichi
RHEUMATOLOGY Vol. 56 page： 75-75 2017.3
KAKENHI (Grants-in-Aid for Scientific Research) 3
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特異的な間葉系幹細胞マーカーMeflinを介した腎線維化の機序解明と治療法の開発
Grant number：20K08589 2020.4 - 2023.3
齋藤 尚二
Authorship：Principal investigator
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
1）Meflinの正常腎ならびに疾患モデルマウスにおける発現を正常マウスならびにMeflinノックアウトマウスを用いて解析する
2）Meflin陽性細胞の腎線維化に関する役割をMeflin-CreERT2;Rosa26-LSL-tdtomatoマウスを用いて経時的・空間的に系譜追跡し解明する
3）Meflin-ZsGreen-DTR-Creマウスを用いてMeflin陽性細胞を消去し、その役割を解明する
4）Meflinの発現を誘導することにより、腎線維化進展や臓器不全の予防につながる治療法を開発する -
Improvement of BK virus monitoring system in renal transplantation with the aim of graft long-term survival.
Grant number：19K09680 2019.4 - 2022.3
Authorship：Coinvestigator(s)
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Analysis of the role of mesenchymal stem cell marker Meflin in kidney fibrosis
Grant number：17K09696 2017.4 - 2020.3
Saito Shoji
Authorship：Principal investigator
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
Fibrosis is a key regulator of organ damage.myofibroblast is essential for rise of fibrosis, and it is said that MSC is one of the origin. We previously report that a cell surface and secreted protein, Meflin, is expressed in cultured MSCs, fibroblasts and pericytes, but not other types of cells including epithelial, endothelial and smooth muscle cells. We also found Meflin is a potential marker for cultured MSCs and focused on the mechanism of fibrosis by investigating Meflin.
We discovered that Meflin expresses in intersititum and around the vascular pole of glomerulus. And its’ expression increases when glomerular inflammation and fibrosis progresses.We also investigated the manner of Meflin positive cells with Meflin reporter mice generated in our lab.
In vitro study also suggested that Meflin is positively regulating kidney fibrosis.