Updated on 2021/10/19

写真a

 
SAITO Shoji
 
Organization
Nagoya University Hospital Nephrology Lecturer of hospital
Title
Lecturer of hospital

Degree 1

  1. 博士(医学) ( 2011.1   名古屋大学 ) 

Research Areas 1

  1. Life Science / Nephrology

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2011.1

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    Country: Japan

  2. Nagoya City University   Faculty of Medicine

    - 2001.3

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    Country: Japan

Professional Memberships 4

  1. 臨床腎移植学会

  2. 日本内科学会

  3. 日本腎臓学会

  4. 日本透析医学会

 

Papers 9

  1. Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis.

    Ryuge A, Kim H, Suzuki Y, Okazaki M, Kojima H, Saito S, Kato N, Ishimoto T, Kosugi T, Maruyama S, Mizuno M

    Internal medicine (Tokyo, Japan)     2021.2

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    Language:English  

    DOI: 10.2169/internalmedicine.6632-20

    PubMed

  2. Efficacy of favipiravir for an end stage renal disease patient on maintenance hemodialysis infected with novel coronavirus disease 2019

    Koshi Eri, Saito Shoji, Okazaki Masaki, Toyama Yuki, Ishimoto Takuji, Kosugi Tomoki, Hiraiwa Hiroaki, Jingushi Naruhiro, Yamamoto Takanori, Ozaki Masayuki, Goto Yukari, Numaguchi Atsushi, Miyagawa Yasuhiro, Kato Io, Tetsuka Nobuyuki, Yagi Tetsuya, Maruyama Shoichi

    CEN CASE REPORTS   Vol. 10 ( 1 ) page: 126 - 131   2021.2

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  3. Acquired Fanconi Syndrome in a Patient with Nontyphoidal Salmonella Bacteremia

    Ryuge Akihiro, Saito Shoji, Morioka Hiroshi, Hachiya Asaka, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi

    INTERNAL MEDICINE   Vol. 60 ( 5 ) page: 761 - 764   2021

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  4. Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors

    Sakurai Yasutaka, Ichinoe Masaaki, Yoshida Kazuki, Nakazato Yuka, Saito Shoji, Satoh Masashi, Nakada Norihiro, Sanoyama Itaru, Umezawa Atsuko, Numata Yoshiko, Jiang Shi-Xu, Ichihara Masatoshi, Takahashi Masahide, Murakumo Yoshiki

    CANCER LETTERS   Vol. 489   page: 100 - 110   2020.10

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  5. Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia

    Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 59 ( 5 ) page: 683 - 687   2020

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  6. Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction

    Hara Akitoshi, Kobayashi Hiroki, Asai Naoya, Saito Shigeyoshi, Higuchi Takahiro, Kato Katsuhiro, Okumura Takahiro, Bando Yasuko K., Takefuji Mikito, Mizutani Yasuyuki, Miyai Yuki, Saito Shoji, Maruyama Shoichi, Maeda Keiko, Ouchi Noriyuki, Nagasaka Arata, Miyata Takaki, Mii Shinji, Kioka Noriyuki, Worthley Daniel L., Murohara Toyoaki, Takahashi Masahide, Enomoto Atsushi

    CIRCULATION RESEARCH   Vol. 125 ( 4 ) page: 414 - 430   2019.8

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  7. Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study

    Katsuno Takayuki, Masuda Tomohiro, Saito Shoji, Kato Noritoshi, Ishimoto Takuji, Kato Sawako, Kosugi Tomoki, Tsuboi Naotake, Kitamura Hiroshi, Tsuzuki Toyonori, Ito Yasuhiko, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 23 ( 2 ) page: 207-214   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-018-1630-y

    Web of Science

    PubMed

  8. High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis.

    Xu X, Tan X, Tampe B, Wilhelmi T, Hulshoff MS, Saito S, Moser T, Kalluri R, Hasenfuss G, Zeisberg EM, Zeisberg M

    Nature communications   Vol. 9 ( 1 ) page: 3509   2018.8

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    Language:English  

    DOI: 10.1038/s41467-018-05766-5

    PubMed

  9. A CASE OF RAPIDLY PROGRESSIVE NEPHRITIC SYNDROME AND NEPHROTIC SYNDROME DURING THE TREATMENT OF DERMATOMYOSITIS AND DIABETES

    Sato Naokazu, Katsuno Takayuki, Mori Masayoshi, Saito Shouji, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Ito Yasuhiko, Maruyama Shouichi

    RHEUMATOLOGY   Vol. 56   page: 75-75   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 特異的な間葉系幹細胞マーカーMeflinを介した腎線維化の機序解明と治療法の開発

    Grant number:20K08589  2020.4 - 2023.3

    齋藤 尚二

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    1)Meflinの正常腎ならびに疾患モデルマウスにおける発現を正常マウスならびにMeflinノックアウトマウスを用いて解析する
    2)Meflin陽性細胞の腎線維化に関する役割をMeflin-CreERT2;Rosa26-LSL-tdtomatoマウスを用いて経時的・空間的に系譜追跡し解明する
    3)Meflin-ZsGreen-DTR-Creマウスを用いてMeflin陽性細胞を消去し、その役割を解明する
    4)Meflinの発現を誘導することにより、腎線維化進展や臓器不全の予防につながる治療法を開発する

  2. Improvement of BK virus monitoring system in renal transplantation with the aim of graft long-term survival.

    Grant number:19K09680  2019.4 - 2022.3

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    Authorship:Coinvestigator(s) 

  3. Analysis of the role of mesenchymal stem cell marker Meflin in kidney fibrosis

    Grant number:17K09696  2017.4 - 2020.3

    Saito Shoji

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    Fibrosis is a key regulator of organ damage.myofibroblast is essential for rise of fibrosis, and it is said that MSC is one of the origin. We previously report that a cell surface and secreted protein, Meflin, is expressed in cultured MSCs, fibroblasts and pericytes, but not other types of cells including epithelial, endothelial and smooth muscle cells. We also found Meflin is a potential marker for cultured MSCs and focused on the mechanism of fibrosis by investigating Meflin.
    We discovered that Meflin expresses in intersititum and around the vascular pole of glomerulus. And its’ expression increases when glomerular inflammation and fibrosis progresses.We also investigated the manner of Meflin positive cells with Meflin reporter mice generated in our lab.
    In vitro study also suggested that Meflin is positively regulating kidney fibrosis.