Updated on 2025/04/04

写真a

 
MIZUNO Tetsuya
 
Organization
Nagoya University Hospital Thoracic Surgery Lecturer of hospital
Title
Lecturer of hospital

Degree 1

  1. 博士(医学) ( 2012.3   名古屋大学 ) 

Research History 7

  1. 名古屋大学医学部付属病院 呼吸器外科 医員

    2011.10 - 2012.3

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    Country:Japan

  2. 愛知県がんセンター研究所 分子腫瘍学部 リサーチレジデント

    2010.4 - 2011.9

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    Country:Japan

  3. 愛知県がんセンター研究所 分子腫瘍学部 研修生

    2009.4 - 2010.3

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    Country:Japan

  4. 名古屋大学医学部付属病院 呼吸器外科 医員

    2008.4 - 2009.3

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    Country:Japan

  5. 国立がんセンター東病院 呼吸器外科レジデント

    2005.4 - 2008.3

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    Country:Japan

  6. 愛知県立尾張病院 外科

    2003.4 - 2005.3

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    Country:Japan

  7. 小牧市民病院 研修医

    2001.5 - 2003.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2008.4 - 2012.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 2001.3

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    Country: Japan

Professional Memberships 4

  1. 日本肺癌学会

  2. 日本胸部外科学会

  3. 日本呼吸器外科学会

  4. 日本外科学会

 

Papers 30

  1. Identification of a low risk subgroup of stage IB lung adenocarcinoma patients.

    Mizuno T, Ishii G, Nagai K, Yoshida J, Nishimura M, Mochizuki T, Kawai O, Hasebe T, Ochiai A

    Lung Cancer   ( 62 ) page: 302-308   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

  2. Schwannoma of the sternum.

    Mizuno T, Usami N, Taniguchi T, Kawaguchi K, Okagawa T, Yokoi K

    Ann Thorac Surg   Vol. 89 ( 4 ) page: 1280-1   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

  3. Complete spontaneous regression of non-small cell lung cancer followed by adrenal relapse.

    Mizuno T, Usami N, Okasaka T, Kawaguchi K, Okagawa T, Yokoi K

    Chest   Vol. 140 ( 2 ) page: 527-8   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

  4. YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.

    Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S, Yokoi K, Osada H, Sekido Y

    Oncogene     page: In Press   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

  5. Pulmonary metastasectomy for osteogenic and soft tissue sarcoma: who really benefits from surgical treatment?

    Mizuno T, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Ishiguro F, Nakamura S, Yokoi K

    Eur J Cardiothorac Surg.     page: In Press   2012

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  6. A Case of Myasthenia Gravis and Stiff-Person Syndrome That Improved After Extended Thymectomy Open Access

    Okado, S; Mizuno, T; Kawasumi, Y; Kadomatsu, Y; Chen-Yoshikawa, TF

    RESPIROLOGY CASE REPORTS   Vol. 13 ( 3 ) page: e70149   2025.3

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    Language:English   Publisher:Respirology Case Reports  

    In cases of thymoma with autoimmune disease, extended thymectomy may improve disease symptoms and medication effects. Myasthenia gravis (MG) is the most common complication, but thymoma with Stiff-Person syndrome (SPS) is rare, and there are few reports of surgery. In the present case, we performed robot-assisted extended thymectomy on a 74-year-old man with thymoma who had MG and SPS. At 6 months after surgery, his MG and SPS symptoms had improved and the dose of prednisolone had been reduced, confirming that surgical treatment contributed to disease control. Thus far, only two studies have been published on thymoma surgery in conjunction with MG and SPS, and both have documented the progression of neurological symptoms after surgery. To the best of our knowledge, this is the first report of a resected thymoma with MG and SPS, both of which were controlled after surgery.

    DOI: 10.1002/rcr2.70149

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  7. Lobectomy for primary lung cancer: a comparison of perioperative and postoperative outcomes between robot-assisted thoracic surgery and video-assisted thoracic surgery Open Access

    Ueno, H; Imamura, Y; Okado, S; Nomata, Y; Watanabe, H; Kawasumi, Y; Nakanishi, K; Kadomatsu, Y; Kato, T; Nakamura, S; Mizuno, T; Chen-Yoshikawa, TF

    SURGERY TODAY     2025.2

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    Language:English   Publisher:Surgery Today  

    Purpose: This study compared the peri- and postoperative outcomes of robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) lobectomy for primary lung cancer. Methods: This retrospective cohort study included patients who underwent RATS or VATS at Nagoya University Hospital between April 2018 and March 2022. Propensity score matching was used to balance patient characteristics between the two groups. The following long-term outcomes were assessed: the 3-year overall survival (OS), causes of death, 3-year disease-free survival (DFS), and recurrence patterns. Various peri- and postoperative outcomes were examined as short-term outcomes. Results: After propensity score-matching, 137 patients were included in each group. RATS was associated with a longer operative time (median 180 vs. 144 min, p < 0.001), less blood loss (median 5 vs. 12 ml, p = 0.005), and a lower rate of conversion to open thoracotomy (1 [0.7%] vs. 10 [7.4%], p = 0.010) than VATS. The 3-year OS and DFS were comparable between the groups. Conclusion: In lobectomy for lung cancer, RATS demonstrated long-term outcomes that were comparable to those of VATS. Although RATS has a longer operative time, it is associated with less blood loss and a lower conversion rate to open thoracotomy than VATS, suggesting that it is a beneficial surgical approach for patients.

    DOI: 10.1007/s00595-025-03000-6

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  8. 特集 あらためて考える-肺癌周術期治療 課題とこれから Ⅳ.白金製剤を用いた周術期治療 白金製剤を用いた術前治療後の手術

    水野 鉄也, 芳川 豊史

    呼吸器ジャーナル   Vol. 73 ( 1 ) page: 67 - 71   2025.2

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    Publisher:株式会社 医学書院  

    DOI: 10.11477/mf.243232680730010067

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  9. Accuracy of lung structure constructed by three-dimensional image analysis with non-enhanced computed tomography Open Access

    Noritake, O; Okado, S; Kadomatsu, Y; Ueno, H; Kato, T; Nakamura, S; Mizuno, T; Chen-Yoshikawa, TF

    JOURNAL OF THORACIC DISEASE   Vol. 17 ( 2 ) page: 816 - 823   2025.2

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    Language:English   Publisher:Journal of Thoracic Disease  

    Background: There are few papers on three-dimensional (3D) images of the lungs using non-enhanced computed tomography (CT). This study aimed to investigate the accuracy of 3D images of the lungs using non-enhanced CT. Methods: The study included 10 consecutive cases for each lung lobe, totalling 50 cases between March and December 2022. The patients had both non-enhanced and contrast-enhanced CT taken within 2 months before surgery. A 3D image analysis system (SYNAPSE VINCENT) was used to obtain 3D images of the pulmonary artery (PA), pulmonary vein (PV), and bronchus (Br). The system automatically generated 3D images based on both non-enhanced and contrast-enhanced CTs, which were then compared with each other and also with actual surgical findings. Results: The coincidence rate of PA, PV, and Br between 3D images based on non-enhanced CT and enhanced CT was 70% for the right lung and 65% for the left lung. The coincidence rate of PA, PV, and Br between 3D images based on non-enhanced CT and actual surgical findings was 100% for the right middle, right lower, and left lower lobes, but 50% for the right upper lobe and 60% for the left upper lobe. Conclusions: The 3D images of the lungs based on non-enhanced CT showed that the right middle lobe and both lower lobes were correctly depicted. The right and left upper lobes were poorly visualized using non-enhanced CT, while the right upper lobe was poorly visualized using contrast-enhanced CT.

    DOI: 10.21037/jtd-24-1406

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  10. Avoiding extracorporeal membrane oxygenation using dual-lung ventilation: Carinal resection and left pneumonectomy for adenoid cystic carcinoma Open Access

    Nakamura S., Nomata Y., Imamura Y., Okado S., Watanabe H., Kawasumi Y., Kadomatsu Y., Ueno H., Kato T., Mizuno T., Chen-Yoshikawa T.F.

    JTCVS Techniques     2025

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    Publisher:JTCVS Techniques  

    DOI: 10.1016/j.xjtc.2025.02.004

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  11. Managing recurrent thymic epithelial tumors after resection: outcomes and role of re-resection Open Access

    Mizuno T., Chen-Yoshikawa T.F.

    Mediastinum   Vol. 8   page: 49   2024.12

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    Language:English   Publisher:Mediastinum  

    Thymic epithelial tumors (TETs) are rare neoplasms that include thymomas, thymic carcinomas (TCs), and thymic neuroendocrine neoplasms (TNENs). These three tumor categories differ in aggressiveness, the incidence of recurrence after resection, the pattern of recurrence, and survival outcomes. Owing to the tumor’s rarity, randomized trials have not been performed in the initial treatment setting. Furthermore, such trials have never been performed in recurrent cases after the initial resection. Thymomas have indolent characteristics, with a wide range of biological spectra compared to TCs and TNENs; therefore, several authors have reported favorable outcomes after re-resection for recurrent thymomas. Common recurrent sites are the local site and pleura, and recurrent disease progresses slowly after detection. Additionally, long-term survivors are sometimes observed after recurrence, and whether re-resections contribute to post-recurrent and cause-specific survival remains unclear. Multimodal therapies are indicated in patients with locally or regionally advanced recurrence, similar to those performed in the initial treatment settings. TCs and TNENs exhibit more aggressive behavior than thymomas. Surgical resection was performed on selected patients who experienced recurrence. Currently, there are no guidelines on selecting patients for re-resection. Therefore, it is most likely that each physician selects based on favorable factors, including the extent of disease, disease-free intervals, and histology. No evidence of nonsurgical treatments, such as radiotherapy or chemotherapy, has yet to be established. This review article summarizes the limited evidence on managing recurrent TETs after resection compared to thymomas, TCs, and TNENs, focusing on re-resection.

    DOI: 10.21037/med-24-26

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  12. Development of a machine learning-based risk model for postoperative complications of lung cancer surgery Open Access

    Kadomatsu, Y; Emoto, R; Kubo, Y; Nakanishi, K; Ueno, H; Kato, T; Nakamura, S; Mizuno, T; Matsui, S; Chen-Yoshikawa, TF

    SURGERY TODAY   Vol. 54 ( 12 ) page: 1482 - 1489   2024.12

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    Purpose: To develop a comorbidity risk score specifically for lung resection surgeries. Methods: We reviewed the medical records of patients who underwent lung resections for lung cancer, and developed a risk model using data from 2014 to 2017 (training dataset), validated using data from 2018 to 2019 (validation dataset). Forty variables were analyzed, including 35 factors related to the patient’s overall condition and five factors related to surgical techniques and tumor-related factors. The risk model for postoperative complications was developed using an elastic net regularized generalized linear model. The performance of the risk model was evaluated using receiver operating characteristic curves and compared with the Charlson Comorbidity Index (CCI). Results: The rate of postoperative complications was 34.7% in the training dataset and 21.9% in the validation dataset. The final model consisted of 20 variables, including age, surgical-related factors, respiratory function tests, and comorbidities, such as chronic obstructive pulmonary disease, a history of ischemic heart disease, and 12 blood test results. The area under the curve (AUC) for the developed risk model was 0.734, whereas the AUC for the CCI was 0.521 in the validation dataset. Conclusions: The new machine learning model could predict postoperative complications with acceptable accuracy. Clinical registration number: 2020–0375.

    DOI: 10.1007/s00595-024-02878-y

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  13. A case of peribronchiolar metaplasia of the lung appearing as a solid nodule on computed tomography Open Access

    Takada, Y; Nakamura, S; Imamura, Y; Okado, S; Nomata, Y; Watanabe, H; Kadomatsu, Y; Ueno, H; Kato, T; Mizuno, T; Kojima, I; Chen-Yoshikawa, TF

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 86 ( 4 ) page: 720 - 725   2024.11

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    Peribronchiolar metaplasia is an uncommon lesion characterized by fibrosis and bronchiolar epithelial cell proliferation along the peribronchiolar alveolar walls, primarily in response to bronchiolar and peribronchiolar injuries. Peribronchiolar metaplasia usually appears as ground glass nodules or sub-solid nodules on computed tomography. However, we present an exceptional case of peribronchiolar metaplasia that appeared as a solitary solid nodule on computed tomography. A 62-year-old woman with conjunctival icterus was diagnosed with ampullary cancer and nodal metastasis. A solid predominant nodule (0.7 cm maximum diameter) in the left lower lobe was identified on computed tomography, requiring accurate differentiation between primary lung cancer and pulmonary metastasis. Due to the location, histological confirmation via transbronchial biopsy was not feasible. Hence, the patient underwent surgery for both diagnosis and treatment. The pathological findings revealed the growth of columnar epithelium containing ciliated cells replacing alveolar epithelium in the bronchioloalveolar wall with no malignant component. The final pathological diagnosis of the lesion was peribronchiolar metaplasia. This unique case highlights an atypical presentation of peribronchiolar metaplasia as a solitary solid nodule on computed tomography. Recognizing that peribronchiolar metaplasia can also manifest as solid nodules, as illustrated in our current case, is essential.

    DOI: 10.18999/nagjms.86.4.720

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  14. Impact of the expanded indication of robot-assisted thoracic surgery for mediastinal tumors

    Kato, T; Watanabe, H; Kawasumi, Y; Kadomatsu, Y; Ueno, H; Nakamura, S; Mizuno, T; Chen-Yoshikawa, TF

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY     2024.10

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    Language:English   Publisher:General Thoracic and Cardiovascular Surgery  

    Objective: Following the introduction of robot-assisted thoracoscopic surgery (RATS) as a health insurance-covered treatment in Japan, we investigated the current status and impact of the expansion of the indications for RATS for mediastinal tumors. Methods: Between 2018 and 2022, 209 cases of total mediastinal tumor resection were performed in our hospital. The study period was divided into the first half (January 2018 to June 2020) and the second half (July 2020 to December 2022), and perioperative parameters were compared between the two groups. Results: Ninety-six surgical procedures were performed in the first half and 113 in the second half. The percentage of RATS approach was significantly higher in the second half compared with the first half (P < 0.001). Indications for RATS in the second half compared with the first half were significantly increased in patients with stage II (P < 0.001) and stage III (P = 0.026) thymomas, tumor diameter ≥ 50 mm (P < 0.011), and patients undergoing extended thymectomy for myasthenia gravis (P < 0.009). In respect of short-term postoperative parameters, the estimated intraoperative blood loss (P < 0.035), postoperative drain duration (P < 0.037), and postoperative hospital stay (P < 0.011) were significantly lower in the second half than in the first half. Conclusions: RATS has recently been expanded for mediastinal tumors with improved short-term outcomes in our hospital after health insurance was applied in Japan. In the future, it will be necessary to discuss the further expansion of its indications by taking into account safety and long-term outcomes.

    DOI: 10.1007/s11748-024-02093-z

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  15. Discovery and Clinical Application of Potential Prognostic Genes for Clinical Outcome in Malignant Pleural Mesothelioma

    Kato, T; Okado, S; Huang, H; Imamura, Y; Nomata, Y; Watanabe, H; Kawasumi, Y; Kadomatsu, Y; Ueno, H; Nakamura, S; Mizuno, T; Chen-Yoshikawa, TF

    JOURNAL OF THORACIC ONCOLOGY   Vol. 19 ( 10 ) page: S278 - S278   2024.10

  16. Current Status and Future Perspectives of Preoperative and Intraoperative Marking in Thoracic Surgery Open Access

    Chen-Yoshikawa, TF; Nakamura, S; Ueno, H; Kadomatsu, Y; Kato, T; Mizuno, T

    CANCERS   Vol. 16 ( 19 )   2024.10

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    The widespread implementation of lung cancer screening and thin-slice computed tomography (CT) has led to the more frequent detection of small nodules, which are commonly referred to thoracic surgeons. Surgical resection is the final diagnostic and treatment option for such nodules; however, surgeons must perform preoperative or intraoperative markings for the identification of such nodules and their precise resection. Historically, hook-wire marking has been performed more frequently worldwide; however, lethal complications, such as air embolism, have been reported. Therefore, several surgeons have recently attempted to develop novel preoperative and intraoperative markers. For example, transbronchial markings, such as virtual-assisted lung mapping and intraoperative markings using cone-beam computed tomography, have been developed. This review explores various marking methods that have been practically applied for a better understanding of preoperative and intraoperative markings in thoracic surgery. Recently, several attempts have been made to perform intraoperative molecular imaging and dynamic virtual three-dimensional computed tomography for the localization, diagnosis, and margin assessment of small nodules. In this narrative review, the current status and future perspectives of preoperative and intraoperative markings in thoracic surgery are examined for a better understanding of these techniques.

    DOI: 10.3390/cancers16193284

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  17. Incidence of air leaks in patients undergoing robotic thoracic surgery and video-assisted thoracic surgery Open Access

    Ueno, H; Takada, Y; Imamura, Y; Okado, S; Nomata, Y; Watanabe, H; Nakanishi, K; Kadomatsu, Y; Kato, T; Nakamura, S; Mizuno, T; Chen-Yoshikawa, TF

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 86 ( 3 ) page: 464 - 471   2024.8

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    Postoperative air leakage is the most common complication in surgery for malignant lung tumors, leading to extended hospital stays and substantial medical expenses. This study aimed to identify the incidence and characteristics of intraoperative and postoperative air leaks in both robotic-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS), as well as the causes of persistent air leakage following RATS. We conducted a retrospective analysis of patients who underwent lung resection for malignant lung tumors at our institution from October 2018 to August 2022. We compared the incidence rates of intraoperative air leak, postoperative air leak, and persistent air leak between patients who underwent RATS and those who underwent VATS. Background factors were adjusted using propensity score matching. A subanalysis was performed to compare unexpected air leaks, defined as air leaks not observed intraoperatively but confirmed postoperatively. The study included 295 cases of RATS and 227 cases of VATS. In both the overall population and the matched group (187 cases each for RATS and VATS), RATS demonstrated a significantly higher incidence of persistent air leaks compared to VATS (11% vs 3%, p < 0.01; 9% vs 3%, p = 0.02, respectively). RATS also had a significantly higher incidence of unexpected air leaks compared with VATS (29% vs 18%, p = 0.05). Although there was no statistically significant difference in hospital stays, RATS showed a higher incidence of postoperative persistent air leaks and unexpected postoperative air leaks than VATS.

    DOI: 10.18999/nagjms.86.3.464

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  18. Efficacy of Immune Checkpoint Inhibitors in Postoperative Recurrence of Wild-type EGFR Non-Small Cell Lung Cancer

    Imamura, Y; Kato, T; Nomata, Y; Okado, S; Watanabe, H; Kawasumi, Y; Nakanishi, K; Kadomatsu, Y; Ueno, H; Nakamura, S; Mizuno, T; Hase, T; Tanaka, I; Ishii, M; Yatsuya, H; Chen-yoshikawa, TF

    ANTICANCER RESEARCH   Vol. 44 ( 8 ) page: 3451 - 3461   2024.8

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    Background/Aim: Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of non-small cell lung cancer (NSCLC), but specific outcomes of ICIs treatment among patients with postoperative recurrence of NSCLC remain unclear. The objective of the study was to compare the efficacy of ICIs and chemotherapy with conventional chemotherapy only in patients with postoperative recurrence of epidermal growth factor receptor (EGFR) wild-type NSCLC. Patients and Methods: A retrospective analysis was performed on patients who underwent anatomical lung resection at the Nagoya University Hospital and were treated for postoperative recurrence of wild-type EGFR NSCLC. This study evaluated the prognosis for postoperative recurrence, including ICIs treatment and other clinicopathological factors. Results: Of the 83 patients included in the analysis, 20 patients underwent chemotherapy and 63 patients underwent chemotherapy combined with ICIs. The combination of ICIs and chemotherapy significantly prolonged survival after recurrence (median survival: 33.1 months vs. 22.0 months, p=0.01). In the ICIs group, no significant differences in survival were detected between patients with different programmed death ligand 1 (PD-L1) status (Tumor Proportion Scores: <1%, 1%-49%, ≥50%, p=0.27). Multivariate analysis revealed that postoperative distant recurrence was a significant poor prognostic factor for survival after recurrence (HR=1.85, 95% CI=1.06-3.25, p=0.03), and combining ICIs with chemotherapy significantly improved survival after recurrence (HR=0.43, 95% CI=0.24-0.78, p<0.01). Conclusion: Combination of ICIs with chemotherapy significantly prolonged survival of postoperative recurrence with wild-type EGFR NSCLC regardless of PD-L1 status.

    DOI: 10.21873/anticanres.17165

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  19. Transcriptomic profiling of a late recurrent nuclear protein in testis carcinoma of the lung 14 years after the initial operation: a case report Open Access

    Kato, T; Oyamatsu, H; Hanamatsu, Y; Huang, H; Okado, S; Imamura, Y; Nomata, Y; Watanabe, H; Kadomatsu, Y; Ueno, H; Nakamura, S; Mizuno, T; Hase, T; Takeuchi, T; Chen-Yoshikawa, TF

    TRANSLATIONAL LUNG CANCER RESEARCH   Vol. 13 ( 7 ) page: 1756 - 1762   2024.7

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    Language:English   Publisher:Translational Lung Cancer Research  

    Background: Nuclear protein in testis (NUT) carcinoma (NC) of the lung is a rare cancer that occurs mainly in young adolescents and adults. NC is genetically characterized by NUTM1 rearrangements, which usually take the form of BRD4-NUT fusions. The prognosis for NC is dismal, and treatment with conventional chemotherapeutic regimens is ineffective. Case Description: We herein describe the case of a 53-year-old woman with recurrent NC of the lung 14 years after surgery for nasal cavity cancer. Chest computed tomography revealed a 5.5-cm tumor in the lower lobe of the left lung. We completely resected the recurrent lung NC via thoracotomy. Immunohistochemistry (IHC) of the lung and nasal cavity cancers showed diffuse strong expression of NUT. RNA-seq of the lung NC revealed NUTM1 rearrangement, with a fusion of BRD4 exon 10 to NUTM1 exon 4. This breakpoint has never been reported before. In addition, IHC revealed elevated expression of parathyroid hormone-like hormone in the lung NC but not in the nasal cavity NC, indicating that the lung and nasal cavity NCs were metachronous multiple primary cancers. Conclusions: We experienced a rare recurrence of lung NC 14 years after the initial surgery. The BRD4-NUT fusion consisted of a new breakpoint. Furthermore, the expression pattern of parathyroid hormone-like hormone (PTHLH) suggested that the NCs in the nasal cavity and lung may be metachronous multiple lung cancers. This extremely rare case highlighted the possibility of identifying less malignant NCs in patients with poorly differentiated tumors via fusion gene analysis and the need to develop more effective treatment strategies for this malignancy.

    DOI: 10.21037/tlcr-24-259

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  20. Multidisciplinary treatment of giant thymoma, paving the way to complete surgical resection: a case report Open Access

    Makita, A; Nakamura, S; Setogawa, T; Imamura, Y; Okado, S; Nomata, Y; Watanabe, H; Kawasumi, Y; Kadomatsu, Y; Ueno, H; Kato, T; Mizuno, T; Chen-Yoshikawa, TF

    SURGICAL CASE REPORTS   Vol. 10 ( 1 ) page: 170   2024.7

  21. Updated outcomes of surgical treatment for recurrent thymic tumour: a report from the Japanese nationwide database Open Access

    Mizuno, T; Chen-Yoshikawa, TF; Yoshino, I; Okumura, M; Ikeda, N; Kuroda, K; Maniwa, Y; Kanzaki, M; Suzuki, M

    INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY   Vol. 38 ( 6 )   2024.6

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    Language:English   Publisher:Interdisciplinary Cardiovascular and Thoracic Surgery  

    OBJECTIVES: This study aimed to analyse the surgical outcomes for recurrent thymic epithelial tumours and identify the factors associated with post-recurrence survival, using an updated Japanese nationwide database. METHODS: The cohort that developed recurrence after the initial resection was extracted from an updated database of patients whose thymic epithelial tumours were treated surgically between 1991 and 2010. Furthermore, we reviewed clinicopathological and prognostic factors of re-resected cases. Post-recurrence survival outcomes and cause-specific deaths in non-re-resected cases were also reviewed. RESULTS: We enrolled 191 patients who underwent re-resection and 259 patients who did not. In the surgery group, more patients with early stage disease, less aggressive World Health Organization (WHO) histological classification, initial complete resection and shorter recurrence-free intervals were included. Non-thymic carcinoma, absence of preoperative treatment, longer recurrent-free interval, single-site recurrence and R0-1 re-resection were all significantly favourable prognostic factors for post-recurrence survival in the surgery group, according to univariable analyses. Non-thymic carcinoma histology, longer recurrence-free interval and R0-1 re-resection were identified as independent prognostic factors according to multivariable analysis. The post-recurrence survival of the entire cohort with R2 re-resection was significantly better than that of the non-surgery group, although it was not demonstrated that patients with thymoma who underwent R2 re-resection had significantly better post-recurrence and lower cause-specific death. CONCLUSIONS: R0-1 re-resection was newly identified as a prognostic factor after re-resection, in addition to non-thymic carcinoma histological classification and longer recurrence-free intervals, as documented in the initial report.

    DOI: 10.1093/icvts/ivae064

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  22. Extralobar Pulmonary Sequestration Diagnosed as a Mediastinal Tumor and Resected by Robotic Surgery. Open Access

    Ueno H, Watanabe H, Okado S, Kadomatsu Y, Kato T, Nakamura S, Mizuno T, Chen-Yoshikawa TF

    Annals of thoracic surgery short reports   Vol. 2 ( 2 ) page: 185 - 188   2024.6

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  23. Long term outcomes beyond 5 years after pulmonary resection for non-small-cell lung cancer Reviewed

    Mizuno T, Katsumata S, Konno H, Nagata T, Isaka M, Ohde Y.

    Gen Thorac Cardiovasc Surg   Vol. 72 ( 6 ) page: 401 - 407   2024.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11748-023-01993-w.

  24. CHST4 Gene as a Potential Predictor of Clinical Outcome in Malignant Pleural Mesothelioma Open Access

    Okado, S; Kato, T; Hanamatsu, Y; Emoto, R; Imamura, Y; Watanabe, H; Kawasumi, Y; Kadomatsu, Y; Ueno, H; Nakamura, S; Mizuno, T; Takeuchi, T; Matsui, S; Chen-Yoshikawa, TF

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 25 ( 4 )   2024.2

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    Language:English   Publisher:International Journal of Molecular Sciences  

    Malignant pleural mesothelioma (MPM) develops primarily from asbestos exposures and has a poor prognosis. In this study, The Cancer Genome Atlas was used to perform a comprehensive survival analysis, which identified the CHST4 gene as a potential predictor of favorable overall survival for patients with MPM. An enrichment analysis of favorable prognostic genes, including CHST4, showed immune-related ontological terms, whereas an analysis of unfavorable prognostic genes indicated cell-cycle-related terms. CHST4 mRNA expression in MPM was significantly correlated with Bindea immune-gene signatures. To validate the relationship between CHST4 expression and prognosis, we performed an immunohistochemical analysis of CHST4 protein expression in 23 surgical specimens from surgically treated patients with MPM who achieved macroscopic complete resection. The score calculated from the proportion and intensity staining was used to compare the intensity of CHST4 gene expression, which showed that CHST4 expression was stronger in patients with a better postoperative prognosis. The median overall postoperative survival was 107.8 months in the high-expression-score group and 38.0 months in the low-score group (p = 0.044, log-rank test). Survival after recurrence was also significantly improved by CHST4 expression. These results suggest that CHST4 is useful as a prognostic biomarker in MPM.

    DOI: 10.3390/ijms25042270

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  25. Influencing Factors on Intersegmental Identification Adequacy in Segmentectomy with Intraoperative Indocyanine Green (ICG) Intravenous Administration

    Ueno, H; Setogawa, T; Makita, A; Ohara, Y; Imamura, Y; Okado, S; Watanabe, H; Kawasumi, Y; Kadomatsu, Y; Kato, T; Nakamura, S; Mizuno, T; Chen-Yoshikawa, TF

    CANCERS   Vol. 15 ( 24 )   2023.12

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    Language:English   Publisher:Cancers  

    Accurate identification of the intersegmental plane is essential in segmentectomy, and Indocyanine Green (ICG) assists in visualizing lung segments. Various factors, including patient-related, intraoperative, and technical issues, can influence boundary delineation. This study aims to assess the rate of unsuccessful intersegmental identification and identify the contributing factors. We analyzed cases of lung segmentectomy from April 2020 to March 2023, where intraoperative ICG was intravenously administered during robot-assisted or video-assisted thoracoscopic surgery. Cases where fluorescence extended beyond expected boundaries within 30 s were classified as the “unclear boundary group”. This group was then compared to the “clear boundary group”. The study encompassed 111 cases, 104 (94%) of which were classified under the “clear boundary group” and 7 (6%) under the “unclear boundary group”. The “unclear boundary group” had a significantly lower DLCO (15.7 vs. 11.8, p = 0.03) and DLCO/VA (4.3 vs. 3.0, p = 0.01) compared to the “clear boundary group”. All cases in the “unclear boundary group” underwent lower lobe segmentectomy. ICG administration effectively outlines pulmonary segments. Challenges in segment demarcation may occur in cases with low DLCO and DLCO/VA values, particularly during lower lobe segmentectomy.

    DOI: 10.3390/cancers15245876

    Web of Science

    Scopus

    PubMed

  26. The Impact of Expanded Indication of Robot-Assisted Thoracic Surgery for Mediastinal Tumors

    Kato, T; Takada, Y; Iwashimizu, H; Imamura, Y; Okado, S; Nomata, Y; Watanabe, H; Noritake, O; Nakanishi, K; Kadomatsu, Y; Ueno, H; Nakamura, S; Mizuno, T; Chen-Yoshikawa, TF

    JOURNAL OF THORACIC ONCOLOGY   Vol. 18 ( 11 ) page: S721 - S721   2023.11

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  27. The Prognostic Impact of Postoperative EGFR Mutation Status in Lung Cancer Patients with Stage II - III

    Nakamura, S; Hase, T; Takada, Y; Iwashimizu, H; Imamura, Y; Okado, S; Nomata, Y; Watanabe, H; Noritake, O; Nakanishi, K; Kadomatsu, Y; Ueno, H; Kato, T; Mizuno, T; Ishii, M; Chen-Yoshikawa, TF

    JOURNAL OF THORACIC ONCOLOGY   Vol. 18 ( 11 ) page: S489 - S490   2023.11

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  28. Complete visualization using indocyanine green in thoracic surgery for pulmonary sequestration Open Access

    Nakanishi, K; Kadomatsu, Y; Ueno, H; Kato, T; Nakamura, S; Mizuno, T; Chen-Yoshikawa, TF

    JOURNAL OF THORACIC DISEASE   Vol. 15 ( 10 ) page: 5714 - +   2023.10

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    Language:English   Publisher:Journal of Thoracic Disease  

    Preoperative three-dimensional computed tomography (CT) facilitates accurate identification of aberrant systemic arteries in thoracic surgery for pulmonary sequestration (PS). Furthermore, the boundary between normal and sequestrated lungs can be visualized using the spread of fluorescent indocyanine green (ICG) when performing surgery for PS. This study aimed to determine how to completely visualize anatomical variations, safely treat aberrant arteries, remove only sequestrated lungs, and perform minimally invasive surgery for PS. Seventeen patients underwent lung resection for intralobar PS at our institution between 2009 and 2022. We retrospectively reviewed the surgical outcomes and intraoperative images using ICG to assess the efficacy and feasibility of near-infrared fluorescence imaging. Since 2019, intraoperative near-infrared fluorescence imaging with ICG has been used in six patients, including four females and two males (median age, 56 years), to visualize the boundary between normal and sequestrated lungs. Aberrant arteries were identified using preoperative three-dimensional CT, and the boundary between sequestrated and normal lungs could be clearly delineated intraoperatively using ICG in all cases. The median operative time was 145 min (range, 88–167 min), and the median blood loss was 5 mL (range, 1–191 mL). The overlay mode using near-infrared thoracoscopy, which merges visible light images with fluorescent images, was safer and more useful than conventional thoracoscopy for delineating boundaries with electrocautery. No intraoperative or postoperative complications occurred. The median postoperative hospital stay was 5 days (range, 3–7 days). Intraoperative identification of the boundary between normal and sequestrated lungs using ICG was simple and feasible. We suggested that this technique was effective for lesion resection and normal lung preservation during surgery for intralobar PS.

    DOI: 10.21037/jtd-23-892

    Open Access

    Web of Science

    Scopus

    PubMed

  29. Diagnostic sensitivity of solid volume measurement for pathological invasion in non-solid lung adenocarcinoma Reviewed

    Tetsuya Mizuno, Yukihiro Terada, Shinya Katsumata, Hayato Konno, Toshiyuki Nagata, Mitsuhiro Isaka, Yasuhisa Ohde

    J Thorac Dis   Vol. 15 ( 6 ) page: 2916 - 2925   2023.4

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    Authorship:Lead author, Corresponding author  

  30. Long term outcomes beyond 5 years after pulmonary resection for non-small-cell lung cancer Invited Reviewed

    Tetsuya Mizuno, Shinya Katsumata, Hayato Konno, Toshiyuki Nagata, Mitsuhiro Isaka, Yasuhisa Ohde

    Gen Thorac Cardiovasc Surg   Vol. Online ahead of print   2023

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    Authorship:Lead author, Corresponding author  

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Books 3

  1. What's New in Oncology がん治療エッセンシャルガイド 肺癌 Stage(病期)分類・治療方法の選択・予後

    水野鉄也、久保田馨( Role: Joint author)

    南山堂  2009.9 

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    Language:Japanese

  2. 臨床研修プラクティス II. 見落とさない胸部単純X線読影 4. 縦隔陰影がおかしい

    水野鉄也、横井香平( Role: Joint author)

    文光堂  2009.4 

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    Language:Japanese

  3. 専門医のための呼吸器外科の要点と盲点 【I】 2.手術適応のKnack & Pitfalls 2. 病期が決定できない時、どのような方針が成り立つか?

    水野鉄也、横井香平( Role: Joint author)

    文光堂  2010.5 

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    Language:Japanese