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論文 - 阪本　考司

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Pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis: Comparison with chronic obstructive pulmonary disease

Arizono S., Taniguchi H., Sakamoto K., Kondoh Y., Kimura T., Kataoka K., Ogawa T., Watanabe F., Tabira K., Kozu R.

Sarcoidosis Vasculitis and Diffuse Lung Diseases 34 巻 ( 4 ) 頁： 283 - 289 2017年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Sarcoidosis Vasculitis and Diffuse Lung Diseases

Background: While the efficacy of pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) has been well established, emerging evidence also suggests its benefit in idiopathic pulmonary fibrosis (IPF). However, the differences and similarities between how PR affects diseases with different physiologies remain unknown. Objective: This study aimed to compare the efficacy of PR in COPD and IPF patients by performing multifactorial evaluation with various exercise capacity measurements, and dyspnea and health-related quality of life (QoL) assessment. Methods: Twenty-two IPF patients (%vital capacity: 72%) and 27 COPD patients (%forced expiratory volume1: 43%) were recruited. Subjects who completed a 10-week outpatient PR program were analyzed. We assessed five exercise capacity indicators (6-minute walking distance, incremental shuttle walking distance, endurance time, peak work rate, and peak values for oxygen uptake [peak VO2]), dyspnea (Baseline Dyspnea Index: BDI), and health-related QoL (St. George's Respiratory Questionnaire: SGRQ) at baseline and immediately following completion of the PR program. Results: After 10 weeks of PR, all exercise capacity measurements, except VO2, as well as BDI and SGRQ score improved significantly (p<0.05) in both disease groups. The magnitude of the observed changes in each outcome, assessed by the effect size, was comparable between IPF and COPD patients. This was also true for endurance time, the measurement most responsive to PR, with a large effect size. Conclusions: PR can result in comparable improvements in exercise capacity, including endurance time, and dyspnea and HRQoL in both IPF and COPD patients after 10 weeks of exercise training.

Scopus

Impact of Thin-Section Computed Tomography-Determined Combined Pulmonary Fibrosis and Emphysema on Outcomes Among Patients With Resected Lung Cancer. 査読有り

Hashimoto N, Iwano S, Kawaguchi K, Fukui T, Fukumoto K, Nakamura S, Mori S, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y

The Annals of thoracic surgery 102 巻 ( 2 ) 頁： 440-7 2016年8月

Mean pulmonary arterial pressure as a prognostic indicator in connective tissue disease associated with interstitial lung disease: a retrospective cohort study. 査読有り

Takahashi K, Taniguchi H, Ando M, Sakamoto K, Kondoh Y, Watanabe N, Kimura T, Kataoka K, Suzuki A, Ito S, Hasegawa Y

BMC pulmonary medicine 16 巻 ( 1 ) 頁： 55 2016年4月

Biomarkers in the Evaluation and Management of Idiopathic Pulmonary Fibrosis. 査読有り

Tzouvelekis A, Herazo-Maya J, Sakamoto K, Bouros D

Current topics in medicinal chemistry 16 巻 ( 14 ) 頁： 1587-98 2016年

Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers. 査読有り

Kohnoh T, Hashimoto N, Ando A, Sakamoto K, Miyazaki S, Aoyama D, Kusunose M, Kimura M, Omote N, Imaizumi K, Kawabe T, Hasegawa Y

Cancer cell international 16 巻頁： 33 2016年

Lung-Dominant Connective Tissue Disease: Clinical, Radiologic, and Histologic Features. 査読有り

Omote N, Taniguchi H, Kondoh Y, Watanabe N, Sakamoto K, Kimura T, Kataoka K, Johkoh T, Fujimoto K, Fukuoka J, Otani K, Nishiyama O, Hasegawa Y

Chest 148 巻 ( 6 ) 頁： 1438-1446 2015年12月

Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells. 査読有り

106 巻 ( 12 ) 頁： 1693-704 2015年12月

Recombinant Human Thrombomodulin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. 査読有り

Kataoka K, Taniguchi H, Kondoh Y, Nishiyama O, Kimura T, Matsuda T, Yokoyama T, Sakamoto K, Ando M

Chest 148 巻 ( 2 ) 頁： 436-443 2015年8月

Risk stratification by the lower limit of normal of FEV1/FVC for postoperative outcomes in patients with COPD undergoing thoracic surgery. 査読有り

Osuka S, Hashimoto N, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y

Respiratory investigation 53 巻 ( 3 ) 頁： 117-23 2015年5月

Broader criteria of undifferentiated connective tissue disease in idiopathic interstitial pneumonias. 査読有り

Kondoh Y, Johkoh T, Fukuoka J, Arakawa H, Tanaka T, Watanabe N, Sakamoto K, Kataoka K, Kimura T, Taniguchi H

Respiratory medicine 109 巻 ( 3 ) 頁： 389-96 2015年3月

Endurance time is the most responsive exercise measurement in idiopathic pulmonary fibrosis. 査読有り

Arizono S, Taniguchi H, Sakamoto K, Kondoh Y, Kimura T, Kataoka K, Ogawa T, Watanabe F, Nishiyama O, Nishimura K, Kozu R, Tabira K

Respiratory care 59 巻 ( 7 ) 頁： 1108-15 2014年7月

Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts. 査読有り

Huleihel L, Ben-Yehudah A, Milosevic J, Yu G, Pandit K, Sakamoto K, Yousef H, LeJeune M, Coon TA, Redinger CJ, Chensny L, Manor E, Schatten G, Kaminski N

American journal of physiology. Lung cellular and molecular physiology 306 巻 ( 6 ) 頁： L534-42 2014年3月

Crizotinib-induced acute interstitial lung disease in a patient with EML4-ALK positive non-small cell lung cancer and chronic interstitial pneumonia. 査読有り

Watanabe N, Nakahara Y, Taniguchi H, Kimura T, Kondoh Y, Kataoka K, Sakamoto K

Acta oncologica (Stockholm, Sweden) 53 巻 ( 1 ) 頁： 158-60 2014年1月

Efficacy of combined therapy with cyclosporin and low-dose prednisolone in interstitial pneumonia associated with connective tissue disease. 査読有り

Watanabe N, Sakamoto K, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Ono K, Fukuoka J, Nishiyama O, Hasegawa Y

Respiration; international review of thoracic diseases 87 巻 ( 6 ) 頁： 469-77 2014年

Significance of pulmonary arterial pressure as a prognostic indicator in lung-dominant connective tissue disease. 査読有り

Suzuki A, Taniguchi H, Watanabe N, Kondoh Y, Kimura T, Kataoka K, Matsuda T, Yokoyama T, Sakamoto K, Nishiyama O, Hasegawa Y

PloS one 9 巻 ( 9 ) 頁： e108339 2014年

Endobronchial ultrasound transbronchial needle aspiration in older people. 査読有り

Okachi S, Imai N, Imaizumi K, Hase T, Shindo Y, Sakamoto K, Aso H, Wakahara K, Hashimoto I, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y

Geriatrics & gerontology international 13 巻 ( 4 ) 頁： 986-92 2013年10月

Quadriceps weakness contributes to exercise capacity in nonspecific interstitial pneumonia. 査読有り

Watanabe F, Taniguchi H, Sakamoto K, Kondoh Y, Kimura T, Kataoka K, Ogawa T, Arizono S, Nishiyama O, Hasegawa Y

Respiratory medicine 107 巻 ( 4 ) 頁： 622-8 2013年4月

Pulmonary hypertension as a prognostic indicator at the initial evaluation in idiopathic pulmonary fibrosis. 査読有り

Kimura M, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Nishiyama O, Aso H, Sakamoto K, Hasegawa Y

Respiration; international review of thoracic diseases 85 巻 ( 6 ) 頁： 456-63 2013年

Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells. 査読有り

8 巻 ( 11 ) 頁： e81133 2013年

Predictors of the need to initiate noninvasive ventilation in stable outpatients with acute exacerbation of chronic obstructive pulmonary disease. 査読有り

Taga S, Taniguchi H, Watanabe N, Kondoh Y, Kimura T, Kataoka K, Aso H, Sakamoto K, Hasegawa Y

Internal medicine (Tokyo, Japan) 52 巻 ( 16 ) 頁： 1781-6 2013年

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