Updated on 2021/05/18

写真a

 
SHIMADA Kazuyuki
 
Organization
Nagoya University Hospital Hematology Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer
Contact information
メールアドレス

Degree 1

  1. 博士(医学) ( 2009.3   名古屋大学 ) 

Research Interests 2

  1. 微小環境

  2. 悪性リンパ腫

Research History 6

  1. Nagoya University   Department of Hematology, Nagoya University Hospital   Lecturer

    2016.4

  2. Nagoya University   Institute for Advanced Research   Designated lecturer

    2012.3 - 2016.3

  3. University of Southampton   Cancer Sciences Unit

    2010.4 - 2012.3

  4. Nagoya University   Department of Infectious Disease   Staff member

    2009.10 - 2010.3

  5. University of Southampton   Cancer Sciences Division

    2009.5 - 2009.9

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    Country:United Kingdom

  6. Nagoya University   Department of Hematology   Staff member

    2007.4 - 2007.10

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2009.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 2001.3

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    Country: Japan

Professional Memberships 9

  1. 日本内科学会

  2. 日本血液学会   評議員

  3. 日本癌学会

  4. 日本リンパ網内系学会   評議員

  5. American Society of Clinical Oncology

  6. American Society of Hematology

  7. 日本臨床腫瘍学会

  8. 日本造血細胞移植学会

  9. 日本骨髄腫学会

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Awards 3

  1. 日本癌学会奨励賞

    2012.9   日本癌学会  

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    Country:Japan

  2. 日本血液学会奨励賞

    2009.10   日本血液学会  

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    Country:Japan

  3. 日本白血病研究基金一般研究賞

    2009.10   日本白血病研究基金  

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    Country:Japan

 

Papers 71

  1. Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial Reviewed

    LANCET ONCOLOGY   Vol. 21 ( 4 ) page: 593 - 602   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S1470-2045(20)30059-0

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  2. Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma. Reviewed

    Blood   Vol. 137 ( 11 ) page: 1491 - 1502   2021.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood.2020007245

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  3. Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells Reviewed

    Sakamoto Akihiko, Kunou Shunsuke, Shimada Kazuyuki, Tsunoda Makoto, Aoki Tomohiro, Iriyama Chisako, Tomita Akihiro, Nakamura Shigeo, Hayakawa Fumihiko, Kiyoi Hitoshi

    CANCER SCIENCE   Vol. 110 ( 1 ) page: 269 - 278   2019.1

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    DOI: 10.1111/cas.13873

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  4. Biology and management of primary effusion lymphoma. Invited Reviewed

    Shimada K, Hayakawa F, Kiyoi H

    Blood   Vol. 132 ( 18 ) page: 1879 - 1888   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2018-03-791426

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  5. SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Reviewed

    Takagi, Yusuke; Shimada, Kazuyuki; Shimada, Satoko; Sakamoto, Akihiko; Naoe, Tomoki; Nakamura, Shigeo; Hayakawa, Fumihiko; Tomita, Akihiro; Kiyoi, Hitoshi

    Cancer science   Vol. 107 ( 9 ) page: 1270-80   2016.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13001

  6. Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma. Reviewed

    Shimada, K; Shimada, S; Sugimoto, K; Nakatochi, M; Suguro, M; Hirakawa, A; Hocking, T D; Takeuchi, I; Tokunaga, T; Takagi, Y; Sakamoto, A; Aoki, T; Naoe, T; Nakamura, S; Hayakawa, F; Seto, M; Tomita, A; Kiyoi, H

    Leukemia   Vol. 30 ( 7 ) page: 1568-79   2016.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/leu.2016.67

  7. Efficacy of ofatumumab against rituximab-resistant B-CLL/SLL cells with low CD20 protein expression Reviewed

    Shimada, K. Tomita, A. Saito, S. Kiyoi, H.

    Br J Haematol   Vol. 166 ( 3 ) page: 455-457   2014

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  8. Retrospective analysis of prognostic factors for angioimmunoblastic T-cell lymphoma: a multicenter cooperative study in Japan Reviewed

    Tokunaga, T. Shimada, K. Yamamoto, K. Chihara, D. Ichihashi, T. Oshima, R. Tanimoto, M. Iwasaki, T. Isoda, A. Sakai, A. Kobayashi, H. Kitamura, K. Matsue, K. Taniwaki, M. Tamashima, S. Saburi, Y. Masunari, T. Naoe, T. Nakamura, S. Kinoshita, T.

    Blood   Vol. 119 ( 12 ) page: 2837-43   2012.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2011-08-374371

  9. Presentation and management of intravascular large B-cell lymphoma Invited Reviewed

    Shimada, K. Kinoshita, T. Naoe, T. Nakamura, S.

    Lancet Oncol   Vol. 10 ( 9 )   2009.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S1470-2045(09)70140-8

  10. Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan Reviewed

    Shimada, K. Matsue, K. Yamamoto, K. Murase, T. Ichikawa, N. Okamoto, M. Niitsu, N. Kosugi, H. Tsukamoto, N. Miwa, H. Asaoku, H. Kikuchi, A. Matsumoto, M. Saburi, Y. Masaki, Y. Yamaguchi, M. Nakamura, S. Naoe, T. Kinoshita, T.

    J Clin Oncol   Vol. 26 ( 19 )   2008.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1200/JCO.2007.15.4278

  11. The Positivity of Phosphorylated STAT3 Is a Novel Marker for Favorable Prognosis in Germinal Center B-Cell Type of Diffuse Large B-Cell Lymphoma.

    Morichika K, Karube K, Sakihama S, Watanabe R, Kawaki M, Nishi Y, Nakachi S, Okamoto S, Takahara T, Satou A, Shimada S, Shimada K, Tsuzuki T, Fukushima T, Morishima S, Masuzaki H

    The American journal of surgical pathology   Vol. 45 ( 6 ) page: 832 - 840   2021.6

  12. Expression of programmed cell death ligand-1 by immune cells in the microenvironment is a favorable prognostic factor for primary diffuse large B-cell lymphoma of the central nervous system.

    Tsuyuki Y, Ishikawa E, Kohno K, Shimada K, Ohka F, Suzuki Y, Mabuchi S, Satou A, Takahara T, Kato S, Miyagi S, Ozawa H, Kawano T, Takagi Y, Hiraga J, Wakabayashi T, Nakamura S

    Neuropathology : official journal of the Japanese Society of Neuropathology   Vol. 41 ( 2 ) page: 99 - 108   2021.4

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  13. Follicular T-cell lymphoma mimicking lymphocyte-rich classic Hodgkin lymphoma: a case report of a diagnostic pitfall.

    Sakakibara A, Suzuki Y, Kato H, Yamamoto K, Sakata-Yanagimoto M, Ishikawa Y, Furukawa K, Shimada K, Kohno K, Nakamura S, Satou A, Kato S

    Journal of clinical and experimental hematopathology : JCEH     2021.3

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  14. Severe myasthenia gravis with anti-LRP4 antibodies and Hodgkin lymphoma.

    Hayashi N, Sone J, Fukami Y, Yoshida Y, Kuno S, Shimada K, Atsuta N, Nakamura T, Higuchi O, Katsuno M

    Muscle & nerve   Vol. 63 ( 1 ) page: E2 - E4   2021.1

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    DOI: 10.1002/mus.27079

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  15. Dose-adjusted EPOCH with or without rituximab for aggressive lymphoma patients: real world data.

    Matsuda S, Suzuki R, Takahashi T, Suehiro Y, Tomita N, Izutsu K, Fukuhara N, Imaizumi Y, Shimada K, Nakazato T, Yoshida I, Miyazaki K, Yamaguchi M, Suzumiya J

    International journal of hematology   Vol. 112 ( 6 ) page: 807 - 816   2020.12

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    Publisher:International Journal of Hematology  

    DOI: 10.1007/s12185-020-02984-w

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  16. Phase I study of duvelisib in Japanese patients with relapsed or refractory lymphoma.

    Izutsu K, Kato K, Kiyoi H, Yamamoto G, Shimada K, Akashi K

    International journal of hematology   Vol. 112 ( 4 ) page: 504 - 509   2020.10

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    Publisher:International Journal of Hematology  

    DOI: 10.1007/s12185-020-02929-3

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  17. R-CHOP-14 versus R-CHOP-14/CHASER for upfront autologous transplantation in diffuse large B-cell lymphoma: JCOG0908 study.

    Kagami Y, Yamamoto K, Shibata T, Tobinai K, Imaizumi Y, Uchida T, Shimada K, Minauchi K, Fukuhara N, Kobayashi H, Yamauchi N, Tsujimura H, Hangaishi A, Tominaga R, Suehiro Y, Yoshida S, Inoue Y, Suzuki S, Tokuhira M, Kusumoto S, Kuroda J, Yakushijin Y, Takamatsu Y, Kubota Y, Nosaka K, Morishima S, Nakamura S, Ogura M, Maruyama D, Hotta T, Morishima Y, Tsukasaki K, Nagai H

    Cancer science   Vol. 111 ( 10 ) page: 3770 - 3779   2020.10

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    Publisher:Cancer Science  

    DOI: 10.1111/cas.14604

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  18. Reappraisal of Primary Epstein-Barr Virus (EBV)-positive Diffuse Large B-Cell Lymphoma of the Gastrointestinal Tract: Comparative Analysis Among Immunosuppressed and Nonimmunosuppressed Stage I and II-IV Patients.

    Miyagi S, Ishikawa E, Nakamura M, Shimada K, Yamamura T, Furukawa K, Tanaka T, Mabuchi S, Tsuyuki Y, Kohno K, Sakakibara A, Satou A, Kato S, Fujishiro M, Nakamura S

    The American journal of surgical pathology   Vol. 44 ( 9 ) page: 1173 - 1183   2020.9

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    DOI: 10.1097/PAS.0000000000001499

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  19. PD-L1 expression on tumor or stromal cells of nodal cytotoxic T-cell lymphoma: A clinicopathological study of 50 cases.

    Yamashita D, Shimada K, Kohno K, Kogure Y, Kataoka K, Takahara T, Suzuki Y, Satou A, Sakakibara A, Nakamura S, Asano N, Kato S

    Pathology international   Vol. 70 ( 8 ) page: 513 - 522   2020.8

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    Publisher:Pathology International  

    DOI: 10.1111/pin.12950

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  20. PD-L1 (SP142) expression in neoplastic cells predicts a poor prognosis for patients with intravascular large B-cell lymphoma treated with rituximab-based multi-agent chemotherapy.

    Suzuki Y, Kohno K, Matsue K, Sakakibara A, Ishikawa E, Shimada S, Shimada K, Mabuchi S, Takahara T, Kato S, Nakamura S, Satou A

    Cancer medicine   Vol. 9 ( 13 ) page: 4768 - 4776   2020.7

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    Publisher:Cancer Medicine  

    DOI: 10.1002/cam4.3104

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  21. EBV status has prognostic implication among young patients with angioimmunoblastic T-cell lymphoma.

    Eladl AE, Shimada K, Suzuki Y, Takahara T, Kato S, Kohno K, Elsayed AA, Wu CC, Tokunaga T, Kinoshita T, Sakata-Yanagimoto M, Nakamura S, Satou A

    Cancer medicine   Vol. 9 ( 2 ) page: 678 - 688   2020.1

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    DOI: 10.1002/cam4.2742

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  22. Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma.

    Ishikawa E, Nakamura M, Shimada K, Tanaka T, Satou A, Kohno K, Sakakibara A, Furukawa K, Yamamura T, Miyahara R, Nakamura S, Kato S, Fujishiro M

    Journal of gastroenterology   Vol. 55 ( 1 ) page: 39 - 50   2020.1

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    Publisher:Journal of Gastroenterology  

    DOI: 10.1007/s00535-019-01616-3

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  23. Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas. Reviewed

    Leukemia   Vol. 33 ( 7 ) page: 1687 - 1699   2019.7

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    DOI: 10.1038/s41375-019-0380-5

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  24. Methotrexate-associated lymphoproliferative disorders of T-cell phenotype: clinicopathological analysis of 28 cases.

    Satou A, Tabata T, Miyoshi H, Kohno K, Suzuki Y, Yamashita D, Shimada K, Kawasaki T, Sato Y, Yoshino T, Ohshima K, Takahara T, Tsuzuki T, Nakamura S

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc   Vol. 32 ( 8 ) page: 1135 - 1146   2019.7

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  25. Divergence and heterogeneity of neoplastic PD-L1 expression: Two autopsy case reports of intravascular large B-cell lymphoma. Reviewed

    Sakakibara A, Inagaki Y, Imaoka E, Sakai Y, Ito M, Ishikawa E, Shimada S, Shimada K, Suzuki Y, Nakamura S, Satou A, Kohno K

    Pathology international   Vol. 69 ( 3 ) page: 148 - 154   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pin.12757

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  26. Immune evasion-related extranodal large B-cell lymphoma: A report of six patients with neoplastic PD-L1-positive extranodal diffuse large B-cell lymphoma.

    Suzuki Y, Sakakibara A, Shimada K, Shimada S, Ishikawa E, Nakamura S, Kato S, Takahara T, Asano N, Satou A, Kohno K

    Pathology international   Vol. 69 ( 1 ) page: 13 - 20   2019.1

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    DOI: 10.1111/pin.12742

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  27. Clinicopathological analysis of primary intestinal diffuse large B-cell lymphoma: Prognostic evaluation of CD5, PD-L1, and Epstein-Barr virus on tumor cells

    Ishikawa Eri, Kato Seiichi, Shimada Kazuyuki, Tanaka Tsutomu, Suzuki Yuka, Satou Akira, Kohno Kei, Sakakibara Ayako, Yamamura Takeshi, Nakamura Masanao, Miyahara Ryoji, Goto Hidemi, Nakamura Shigeo, Hirooka Yoshiki

    CANCER MEDICINE   Vol. 7 ( 12 ) page: 6051 - 6063   2018.12

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    DOI: 10.1002/cam4.1875

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  28. Outcomes after R-CHOP in patients with newly diagnosed advanced follicular lymphoma: a 10-year follow-up analysis of the JCOG0203 trial

    Watanabe Takashi, Tobinai Kegsei, Wakabayashi Masashi, Morishima Yasuo, Kobayashi Hirofumi, Kinoshita Tomohiro, Suzuki Takayo, Yamaguchi Motoko, Ando Kiyoshi, Ogura Michinori, Taniwadi Masafumi, Uike Naokuni, Yoshino Tadashi, Nawano Sigeru, Terauchi Takeshi, Hotta Tomomitsu, Nagai Hirokazu, Tsukasaki Kunihiro

    LANCET HAEMATOLOGY   Vol. 5 ( 11 ) page: E520 - E531   2018.11

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  29. Reappraisal of nodal Epstein-Barr Virus-negative cytotoxic T-cell lymphoma: Identification of indolent CD5(+) diseases Reviewed

    Yamashita Daisuke, Shimada Kazuyuki, Takata Katsuyoshi, Miyata-Takata Tomoko, Kohno Kei, Satou Akira, Sakakibara Ayako, Nakamura Shigeo, Asano Naoko, Kato Seiichi

    CANCER SCIENCE   Vol. 109 ( 8 ) page: 2599 - 2610   2018.8

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    DOI: 10.1111/cas.13652

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  30. A prognostic model, including the EBV status of tumor cells, for primary gastric diffuse large B-cell lymphoma in the rituximab era Reviewed

    Ishikawa Eri, Tanaka Tsutomu, Shimada Kazuyuki, Kohno Kei, Satou Akira, EladI Ahmed E., Sakakibara Ayako, Furukawa Kazuhiro, Funasaka Kohei, Miyahara Ryoji, Nakamura Masanao, Goto Hidemi, Nakamura Shigeo, Kato Seiichi, Hirooka Yoshiki

    CANCER MEDICINE   Vol. 7 ( 7 ) page: 3510 - 3520   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cam4.1595

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  31. Early disease progression in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy Reviewed

    Yamaguchi Motoko, Suzuki Ritsuro, Kim Seok Jin, Ko Young Hyeh, Oguchi Masahiko, Asano Naoko, Miyazaki Kana, Terui Yasuhiko, Kubota Nobuko, Maeda Takeshi, Kobayashi Yukio, Amaki Jun, Soejima Toshinori, Saito Bungo, Shimoda Emiko, Fukuhara Noriko, Tsukamoto Norifumi, Shimada Kazuyuki, Choi Ilseung, Utsumi Takahiko, Ejima Yasuo, Kim Won Seog, Katayama Naoyuki

    CANCER SCIENCE   Vol. 109 ( 6 ) page: 2056 - 2062   2018.6

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    DOI: 10.1111/cas.13597

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  32. Bortezomib plus dexamethasone vs thalidomide plus dexamethasone for relapsed or refractory multiple myeloma Reviewed

    Iida Shinsuke, Wakabayashi Masashi, Tsukasaki Kunihiro, Miyamoto Kenichi, Maruyama Dai, Yamamoto Kazuhito, Takatsuka Yoshifusa, Kusumoto Shigeru, Kuroda Junya, Ando Kiyoshi, Kikukawa Yoshitaka, Masaki Yasufumi, Kobayashi Miki, Hanamura Ichiro, Asai Hiroaki, Nagai Hirokazu, Shimada Kazuyuki, Tsukamoto Norifumi, Inoue Yoshiko, Tobinai Kensei

    CANCER SCIENCE   Vol. 109 ( 5 ) page: 1552 - 1561   2018.5

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    DOI: 10.1111/cas.13550

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  33. Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol Reviewed

    Goto Tatsunori, Murata Makoto, Terakura Seitaro, Nishida Tetsuya, Adachi Yoshiya, Ushijima Yoko, Shimada Kazuyuki, Ishikawa Yuichi, Hayakawa Fumihiko, Nishio Nobuhiro, Nishiwaki Satoshi, Hirakawa Akihiro, Kato Katsuyoshi, Takahashi Yoshiyuki, Kiyoi Hitoshi

    MEDICINE   Vol. 97 ( 17 ) page: e0449   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MD.0000000000010449

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  34. Autopsy case report of intravascular large B-cell lymphoma with neoplastic PD-L1 expression Reviewed

    Sakakibara Ayako, Inagaki Yuichiro, Imaoka Eiki, Ishikawa Eri, Shimada Satoko, Shimada Kazuyuki, Suzuki Yuka, Nakamura Shigeo, Satou Akira, Kohno Kei

    JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY   Vol. 58 ( 1 ) page: 32 - 35   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3960/jslrt.17037

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  35. Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome Reviewed

    Shirahata-Adachi Mizuho, Iriyama Chisako, Tomita Akihiro, Suzuki Yasuhiro, Shimada Kazuyuki, Kiyoi Hitoshi

    LEUKEMIA RESEARCH   Vol. 63   page: 90 - 97   2017.12

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    DOI: 10.1016/j.leukres.2017.10.015

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  36. YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma. Reviewed

    Kojima Y, Hayakawa F*, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H.

    Pharmacol Res   Vol. 120   page: 242 - 251   2017.6

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    DOI: 10.1016/j.phrs.2017.04.006

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  37. Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism Reviewed

    Aoki Tomohiro, Shimada Kazuyuki, Sakamoto Akihiko, Sugimoto Keiki, Morishita Takanobu, Kojima Yuki, Shimada Satoko, Kato Seiichi, Iriyama Chisako, Kuno Shunsuke, Harada Yasuhiko, Tomita Akihiro, Hayakawa Fumihiko, Kiyoi Hitoshi

    ONCOTARGET   Vol. 8 ( 8 ) page: 13085 - 13098   2017.2

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    DOI: 10.18632/oncotarget.14393

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  38. Malignant lymphoma with cardiac involvement. Reviewed

    Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H.

    Rinsho Ketsueki   Vol. 58 ( 3 ) page: 239 - 242   2017

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11406/rinketsu.58.239

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  39. Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism. Reviewed

    Aoki T, Shimada K, Sakamoto A, Sugimoto K, Morishita T, Kojima Y, Shimada S, Kato S, Iriymaya C, Kuno S, Harada Y, Tomita A, Hayakawa F, Kiyoi H.

    Oncotarget.   Vol. 8   page: 13085-13098   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotraget.14393

  40. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. Invited Reviewed

    Shimada K

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 58 ( 10 ) page: 2033-2042   2017

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.11406/rinketsu.58.2033

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  41. Peripheral blood cell-free DNA is an alternative tumor DNA source reflecting disease status in myelodysplastic syndromes Reviewed

    Suzuki, Yasuhiro; Tomita, Akihiro; Nakamura, Fumika; Iriyama, Chisako; Shirahata-Adachi, Mizuho; Shimada, Kazuyuki; Akashi, Akimi; Ishikawa, Yuichi; Kaneda, Norio; Kiyoi, Hitoshi

    Cancer science   Vol. 107 ( 9 ) page: 1329-37   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.12994

  42. Live-cell single-molecule imaging of the cytokine receptor MPL for analysis of dynamic dimerization. Reviewed

    Sakamoto A, Tsukamoto T, Furutani Y, Sudo Y, Shimada K, Tomita A, Kiyoi H, Kato T, Funatsu T.

    J Mol Cell Biol.   Vol. 8   page: 553-555   2016

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  43. High-dose chemotherapy followed by autologous stem cell transplantation for relapsed/refractory primary mediastinal large B-cell lymphoma Reviewed

    T Aoki, K Shimada, R Suzuki, K Izutsu, A Tomita, Y Maeda, J Takizawa, K Mitani, T Igarashi, K Sakai, K Miyazaki, K Mihara, K Ohmachi, N Nakamura, H Takasaki, H Kiyoi, S Nakamura, T Kinoshita, M Ogura

    Blood cancer journal   Vol. 5 ( 12 ) page: e372   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bcj.2015.101

  44. Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells. Reviewed

    Sugimoto K, Hayakawa F*, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T

    Sci Rep     2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep13054.

  45. Current understanding and future prospects for intravascular large B-cell lymphoma Invited Reviewed

    Shimada, Kazuyuki

      Vol. 56 ( 8 ) page: 1032-7   2015.8

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    Authorship:Lead author   Language:Japanese  

    DOI: 10.11406/rinketsu.56.1032

  46. Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 zeta Chimeric Antigen Receptor-Modified Effector CD8+ T Cells Reviewed

    Watanabe, K. Terakura, S. Martens, A. C. van Meerten, T. Uchiyama, S. Imai, M. Sakemura, R. Goto, T. Hanajiri, R. Imahashi, N. Shimada, K. Tomita, A. Kiyoi, H. Nishida, T. Naoe, T. Murata, M.

    J Immunol   Vol. 194 ( 3 ) page: 911-920   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  47. Prognostic significance of pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan Reviewed

    Aoki, T. Izutsu, K. Suzuki, R. Nakaseko, C. Arima, H. Shimada, K. Tomita, A. Sasaki, M. Takizawa, J. Mitani, K. Igarashi, T. Maeda, Y. Fukuhara, N. Ishida, F. Niitsu, N. Ohmachi, K. Takasaki, H. Nakamura, N. Kinoshita, T. Nakamura, S. Ogura, M.

    Haematologica   Vol. 99 ( 12 ) page: 1817-1825   2014.12

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  48. De novo DLBCL with a CD20 IHC(+) and FCM(-) phenotype: molecular mechanisms and correlation with rituximab sensitivity Reviewed

    Tokunaga, T. Tomita, A. Sugimoto, K. Shimada, K. Iriyama, C. Hirose, T. Shirahata-Adachi, M. Suzuki, Y. Mizuno, H. Kiyoi, H. Asano, N. Nakamura, S. Kinoshita, T. Naoe, T.

    Cancer Sci     2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.12307

  49. Chemically modified synthetic microRNA-205 inhibits the growth of melanoma cells in vitro and in vivo Reviewed

    Noguchi, S. Iwasaki, J. Kumazaki, M. Mori, T. Maruo, K. Sakai, H. Yamada, N. Shimada, K. Naoe, T. Kitade, Y. Akao, Y.

    Mol Ther   Vol. 21 ( 6 )   2013.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/mt.2013.70

  50. CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737 Reviewed

    Shimada, K. Tomita, A. Minami, Y. Abe, A. Hind, C. K. Kiyoi, H. Cragg, M. S. Naoe, T.

    Exp Hematol   Vol. 40 ( 9 )   2012.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.exphem.2012.05.007

  51. Phase II study of dose-modified busulfan by real-time targeting in allogeneic hematopoietic stem cell transplantation for myeloid malignancy Reviewed

    Kuwatsuka, Y. Kohno, A. Terakura, S. Saito, S. Shimada, K. Yasuda, T. Inamoto, Y. Miyamura, K. Sawa, M. Murata, M. Karasuno, T. Taniguchi, S. Nagafuji, K. Atsuta, Y. Suzuki, R. Fukumoto, M. Naoe, T. Morishita, Y.

    Cancer Sci   Vol. 103 ( 9 )   2012.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1349-7006.2012.02342.x

  52. Retrospective analysis of primary gastric diffuse large B cell lymphoma in the rituximab era: a multicenter study of 95 patients in Japan Reviewed

    Tanaka, T. Shimada, K. Yamamoto, K. Hirooka, Y. Niwa, Y. Sugiura, I. Kitamura, K. Kosugi, H. Kinoshita, T. Goto, H. Nakamura, S.

    Ann Hematol   Vol. 91 ( 3 )   2011.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-011-1306-0

  53. A case report of angioimmunoblastic T cell lymphoma (AITL) with localization of neoplastic clear cells in the outer zone of germinal centers Reviewed

    Murakami, Y. Shimada, K. Kosugi, H. Mori, N.

    Pathol Int   Vol. 61 ( 5 )   2011.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1440-1827.2011.02655.x

  54. Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies Reviewed

    Alduaij, W. Ivanov, A. Honeychurch, J. Cheadle, E. J. Potluri, S. Lim, S. H. Shimada, K. Chan, C. H. Tutt, A. Beers, S. A. Glennie, M. J. Cragg, M. S. Illidge, T. M.

    Blood   Vol. 117 ( 17 )   2011.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2010-07-296913

  55. Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. Reviewed

    Katsumi, Akira; Nishida, Tetsuya; Murata, Makoto; Terakura, Seitaro; Shimada, Kazuyuki; Saito, Shigeki; Kobayashi, Miki; Kodaira, Akari; Shibata, Shinichiro; Oda, Isao; Yagi, Tetsuya; Kiyoi, Hitoshi; Matsushita, Tadashi; Kojima, Tetsuhito; Naoe, Tomoki.

    Journal of clinical and experimental hematopathology   Vol. 51 ( 1 ) page: 63-5   2011

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  56. Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients Reviewed

    Shimada, K. Murase, T. Matsue, K. Okamoto, M. Ichikawa, N. Tsukamoto, N. Niitsu, N. Miwa, H. Asaoku, H. Kosugi, H. Kikuchi, A. Matsumoto, M. Saburi, Y. Masaki, Y. Yamamoto, K. Yamaguchi, M. Nakamura, S. Naoe, T. Kinoshita, T.

    Cancer Sci   Vol. 101 ( 6 )   2010.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1349-7006.2010.01555.x

  57. Concurrent chemoradiotherapy for limited-stage extranodal natural killer/t-cell lymphoma, nasal type

    Shimada, K. Suzuki, R.

    J Clin Oncol   Vol. 28 ( 14 )   2010.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1200/JCO.2009.27.7574

  58. Escape mechanisms from antibody therapy to lymphoma cells: downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation Reviewed

    Sugimoto, T. Tomita, A. Hiraga, J. Shimada, K. Kiyoi, H. Kinoshita, T. Naoe, T.

    Biochem Biophys Res Commun   Vol. 390 ( 1 )   2009.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2009.09.059

  59. Comparative clinicopathological study of primary CNS diffuse large B-cell lymphoma and intravascular large B-cell lymphoma Reviewed

    Imai, H. Shimada, K. Shimada, S. Abe, M. Okamoto, M. Kitamura, K. Kinoshita, T. Shiraishi, T. Nakamura, S.

    Pathol Int   Vol. 59 ( 7 )   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1440-1827.2009.02390.x

  60. Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance Reviewed

    Hiraga, J. Tomita, A. Sugimoto, T. Shimada, K. Ito, M. Nakamura, S. Kiyoi, H. Kinoshita, T. Naoe, T.

    Blood   Vol. 113 ( 20 )   2009.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2008-08-175208

  61. Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography Reviewed

    Shimada, K. Kosugi, H. Shimada, S. Narimatsu, H. Koyama, Y. Suzuki, N. Yuge, M. Nishibori, H. Iwata, Y. Nakamura, S. Naoe, T. Kinoshita, T.

    Int J Hematol   Vol. 88 ( 2 )   2008.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-008-0102-7

  62. Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases Reviewed

    Takahashi, E. Asano, N. Li, C. Tanaka, T. Shimada, K. Shimada, S. Yoshino, T. Kojima, M. Hara, K. Eimoto, T. Nakamura, S.

    Histopathology   Vol. 52 ( 5 )   2008.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2559.2008.02997.x

  63. High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia Reviewed

    Narimatsu, H. Emi, N. Kohno, A. Iwai, M. Yanada, M. Yokozawa, T. Saito, S. Shimada, K. Kiyoi, H. Naoe, T. Yamamoto, K. Morishita, Y.

    Bone Marrow Transplant   Vol. 40 ( 8 )   2007.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.bmt.1705820

  64. Mutations of N-RAS, FLT3 and p53 genes are not involved in the development of acute leukemia transformed from myeloproliferative diseases with JAK2 mutation Reviewed

    Suzuki, M. Abe, A. Kiyoi, H. Murata, M. Ito, Y. Shimada, K. Morishita, Y. Kinoshita, T. Naoe, T.

    Leukemia   Vol. 20 ( 6 )   2006.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.leu.2404186

  65. Severe regimen-related toxicity of second transplantation for graft failure following reduced-intensity cord blood transplantation in an adult patient Reviewed

    Shimada, K. Narimatsu, H. Morishita, Y. Kohno, A. Saito, S. Kato, Y.

    Bone Marrow Transplant   Vol. 37 ( 8 )   2006.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.bmt.1705312

  66. Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis Reviewed

    Shimada, K. Yokozawa, T. Atsuta, Y. Kohno, A. Maruyama, F. Yano, K. Taji, H. Kitaori, K. Goto, S. Iida, H. Morishima, Y. Kodera, Y. Naoe, T. Morishita, Y.

    Bone Marrow Transplant   Vol. 36 ( 2 )   2005.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.bmt.1705020

  67. Conditioning regimen of melphalan, fludarabine and total body irradiation in unmanipulated HLA haploidentical stem cell transplantation based on feto-maternal tolerance Reviewed

    Narimatsu, H. Morishita, Y. Saito, S. Shimada, K. Ozeki, K. Kohno, A. Kato, Y.

    Intern Med   Vol. 43 ( 11 )   2004.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 1063-7

  68. Adenocarcinomatosis of the bone marrow and secondary acute myeloid leukemia Reviewed

    Narimatsu, H. Morishita, Y. Watanabe, N. Saito, S. Shimada, K. Ozeki, K. Kohno, A. Kato, Y. Nagasaka, T.

    Intern Med   Vol. 43 ( 8 ) page: 764-5   2004.10

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  69. Usefulness of bone marrow aspiration for definite diagnosis of Asian variant of intravascular lymphoma: four autopsied cases Reviewed

    Narimatsu, H. Morishita, Y. Saito, S. Shimada, K. Ozeki, K. Kohno, A. Kato, Y. Nagasaka, T.

    Leuk Lymphoma   Vol. 45 ( 8 )   2004.9

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    DOI: 10.1080/10428190410001683769

  70. Primary cutaneous diffuse large B cell lymphoma: a clinically aggressive case Reviewed

    Narimatsu, H. Morishita, Y. Shimada, K. Ozeki, K. Kohno, A. Kato, Y. Nagasaka, T.

    Intern Med   Vol. 42 ( 4 ) page: 354-7   2003.5

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  71. Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164.

    Kurosawa N, Kanemitsu Y, Matsui T, Shimada K, Ishihama H, Muramatsu T.

    Eur J Biochem   Vol. 265   page: 466-472   1999

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MISC 1

  1. A case of reexpansion pulmonary edema and acute pulmonary thromboembolism associated with diffuse large B-cell lymphoma treated with venovenous extracorporeal membrane oxygenation.

    Kazama S, Hiraiwa H, Kimura Y, Ozaki R, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Furusawa K, Morimoto R, Okumura T, Bando YK, Sato T, Shimada K, Kiyoi H, Nakamura G, Yasuda Y, Kasugai D, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Goto Y, Matsuda N, Murohara T

    Journal of cardiology cases   Vol. 23 ( 1 ) page: 53 - 56   2021.1

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    Publisher:Journal of Cardiology Cases  

    DOI: 10.1016/j.jccase.2020.08.013

    Scopus

    PubMed

Presentations 10

  1. Favorable outcomes of newly diagnosed intravascular large B-cell lymphoma patients treated with R-CHOP combined with high-dose methotrexate plus intrathecal chemotherapy: results from a multicenter phase 2 trial (PRIMEUR-IVL) International conference

    Kazuyuki Shimada, Motoko Yamaguchi, Yoshiko Atsuta, Kosei Matsue, Keijiro Sato, Shigeru Kusumoto, Hirokazu Nagai, Jun Takizawa, Noriko Fukuhara, Koji Nagafuji, Kana Miyazaki, Eiichi Ohtsuka, Masataka Okamoto, Yasumasa Sugita, Toshiki Uchida, Satoshi Kayukawa, Atsushi Wake, Daisuke Ennishi, Yukio Kondo, Tohru Izumi, Yoshihiro Kin, Kunihiro Tsukasaki, Daigo Hashimoto, Masaaki Yuge, Atsumi Yanagisawa, Yachiyo Kuwatsuka, Satoko Shimada, Yasufumi Masaki, Nozomi Niitsu, Hitoshi Kiyoi, Ritsuro Suzuki, Takashi Tokunaga, Shigeo Nakamura, Tomohiro Kinoshita, on behalf of IVL study group in Japan

    The 61st ASH Annual Meeting and Exposition  2019.12.8 

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    Event date: 2019.12

    Language:English   Presentation type:Oral presentation (general)  

  2. Current achievement of research and clinical practice in intravascular large B-cell lymphoma Invited

    Kazuyuki Shimada

    2020.10 

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    Event date: 2020.10 - 2020.11

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  3. Significance of exosomes secreted from cancer-associated fibroblasts in lymphoma microenvironment

    Kunou Shunsuke, Shimada Kazuyuki, Hikita Tomoya, Sakamoto Akihiko, Oneyama Chitose, Kiyoi Hitoshi

    CANCER SCIENCE 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  4. 異種移植マウスモデルを用いた血管内大細胞型B細胞リンパ腫の病態解析 Invited

    島田和之

    第54回日本癌治療学会学術集会 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  5. 悪性リンパ腫におけるWHO分類とその運用 Invited

    杉浦由姫乃, 島田和之

    第16回日本検査血液学会学術集会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  6. Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi-Scid IL2Rγnull Mouse Xenograft Model International conference

    7. Shimada K*, Shimada S, Sugimoto K, Hayakawa F, Katayama M, Hirakawa A, Takagi Y, Nakamura S, Seto M, Naoe T, Tomita A, Kiyoi H.

    The 56th Annual Meeting of the American Society of Hematology. 

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    Event date: 2014.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  7. Intravascular large B-cell lymphoma-from bench to bedside. Invited

    Shimada K.

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    Event date: 2014.11

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  8. 血管内大細胞型B細胞リンパ腫の治療戦略 Invited

    島田和之, 木下朝博

    第53回日本リンパ網内系学会総会 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  9. 血管内大細胞型B細胞リンパ腫の臨床成績の向上に関する研究 Invited

    島田和之

    第71回日本癌学会学術総会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  10. Presentation and management of intravascular large B-cell lymphoma Invited

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    Event date: 2011.10

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 3

  1. 悪性リンパ腫の臓器指向性を規定する腫瘍細胞と微小環境構成細胞の相互作用の解明と革新的な分子標的治療法の開発

    2017.4

  2. 悪性リンパ腫の腫瘍細胞と微小環境構成細胞の比較解析と微小環境構成細胞による腫瘍支持機構を標的とする新規治療法の開発

    2014.8 - 2017.3

    革新的がん医療実用化研究事業 

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    Grant type:Competitive

  3. 悪性リンパ腫細胞の臓器指向性のメカニズム解明と責任遺伝子を標的とした革新的治療法の開発

    2014.1 - 2015.3

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 悪性リンパ腫の多様性から解く臓器指向性の解明と新規治療への応用

    Grant number:20K08751  2020.4 - 2023.3

    島田 和之

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    悪性リンパ腫は、リンパ節を病変の主座とする節性リンパ腫、節外臓器を病変の主座とする節外性リンパ腫に大別される。本研究では、節性リンパ腫病変においては、微小環境を構成するがん関連線維芽細胞(CAF)より分泌されるエクソソームに焦点をおき、エクソソームがもたらす腫瘍細胞への薬剤感受性変化および周囲の免疫担当細胞への影響について検討する。節外性リンパ腫病変においては、これまでの検討で見出した中枢神経病変に強発現する遺伝子の機能を解析するとともに、中枢神経病変形成に関連する腫瘍細胞のクローン性について検討する。また血管内病変を形成する血管内リンパ腫に対する新たな免疫療法の可能性を探索する。

  2. 悪性リンパ腫の臓器指向性に関わる腫瘍細胞と微小環境の相互作用の解明と新規治療開発

    2017.4 - 2020.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  3. Elucidation of interaction between lymphoma cells and tumor microenvironment involved in organ tropism and development of novel therapies

    Grant number:17K09922  2017.4 - 2020.3

    KAZUYUKI SHIMADA

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    In this study, we elucidated that cancer associated fibroblasts (CAFs) derived from nodal lesion of malignant lymphoma enhanced glucose metabolism in lymphoma cells leading to those survival through the secretion of pyruvate and exosomes from CAFs. We also elucidated that emetine, approved as an emetic and anti-protozoal drug, demonstrated a therapeutic effect on intractable B-cell lymphoma cells through the inhibition of glucose metabolism. Moreover, we elucidated that exosomes were involved in a susceptibility to anti-pyrimidine drug through the modulation of its transporter. In terms of extranodal lesion of malignant lymphoma, we identified a gene that is specifically expressed in the central nervous system (CNS) lesions and demonstrated that the gene is involved in those formation.

  4. 悪性リンパ腫の臓器指向性のメカニズム解明と節外臓器浸潤を抑制する新規治療法の開発

    2014.4 - 2017.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  5. 創薬に向けた白血病のトランスレーショナルリサーチ

    2014.4 - 2016.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

  6. 悪性リンパ腫における微小環境依存性と治療開発に関する研究

    2013.4 - 2015.3

    科学研究費補助金 

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    Authorship:Coinvestigator(s) 

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Industrial property rights 1

  1. 血液関連疾患患者のリンパ節由来の間質細胞

    清井仁, 冨田章裕, 早川文彦, 島田和之, 坂本明彦

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    Application no:2015-132000  Date applied:2015.6

    Announcement no:2017-012078  Date announced:2017.1

    Country of applicant:Domestic