Updated on 2022/04/02

写真a

 
WAKAHARA Keiko
 
Organization
Nagoya University Hospital Respiratory Medicine Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 博士(医学) ( 2007.12   名古屋大学 ) 

Research Interests 3

  1. 呼吸器内科

  2. アレルギー

  3. 免疫

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2006.3

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    Country: Japan

  2. Gifu University   Faculty of Medicine

    - 1998.3

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    Country: Japan

Professional Memberships 6

  1. 日本内科学会

  2. 日本呼吸器学会

  3. 日本呼吸器内視鏡学会

  4. 日本アレルギー学会

  5. 日本呼吸ケア・リハビリテーション学会

  6. 日本結核・非結核性抗酸菌症学会

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Papers 63

  1. Basophils are recruited to inflamed lungs and exacerbate memory Th2 responses in mice and humans. Reviewed

    Wakahara K, Van VQ, Baba N, Begin P, Rubio M, Delespesse G, Sarfati M

    Allergy   Vol. 68 ( 2 ) page: 180 - 189   2013.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/all.12072

    Web of Science

  2. Airway basophils are increased and activated in eosinophilic asthma. Reviewed

    Suzuki Y, Wakahara K, Nishio T, Ito S, Hasegawa Y.

    Allergy.   Vol. 72 ( 10 ) page: 1532-1539   2017.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/all.13197.

  3. Human Basophils interact with memory T cells to augment Th17 responses. Reviewed

    Wakahara K, Baba N, Van VQ, Begin P, Rubio M, Ferraro P, Panzini B, Wassef R, Lahaie R, Caussignac Y, Tamaz R, Richard C, Soucy G, Delespesse G, Sarfati M

    Blood   Vol. 120 ( 24 ) page: 4761 - 4771   2012.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2012-04-424226

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    PubMed

  4. Basophils increase in Crohn disease and ulcerative colitis and favor mesenteric lymph node memory TH17/TH1 response. Reviewed

    Chapuy L, Bsat M, Mehta H, Rubio M, Wakahara K, Van VQ, Baba N, Cheong C, Yun TJ, Panzini B, Wassef R, Richard C, Tamaz R, Soucy G, Delespesse G, Sarfati M.

    J Allergy Clin Immunol.   Vol. 134 ( 4 ) page: 978-981   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaci.2014.05.025.

  5. Mutual Interaction of Basophils and T Cells in Chronic Inflammatory Diseases. Invited Reviewed

    Sarfati M, Wakahara K, Chapuy L, Delespesse G.

    Front Immunol.   Vol. 6   page: 399   2015.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fimmu.2015.00399

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  6. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline.

    Iwama S, Kobayashi T, Yasuda Y, Okuji T, Ito M, Ando M, Zhou X, Yamagami A, Onoue T, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Hase T, Morise M, Wakahara K, Yokota K, Kato M, Nishio N, Tanaka C, Miyata K, Ogura A, Ito T, Sawada T, Shimokata T, Niimi K, Ohka F, Ishigami M, Gotoh M, Hashimoto N, Saito R, Kiyoi H, Kajiyama H, Ando Y, Hibi H, Sone M, Akiyama M, Kodera Y, Arima H

    The Journal of clinical endocrinology and metabolism   Vol. 107 ( 4 ) page: e1620 - e1630   2022.3

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    DOI: 10.1210/clinem/dgab829

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  7. Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor beta-induced profibrotic responses in lung fibroblasts

    Fukihara Jun, Maiolo Suzanne, Kovac Jessica, Sakamoto Koji, Wakahara Keiko, Hashimoto Naozumi, Reynolds Paul N.

    EXPERIMENTAL LUNG RESEARCH   Vol. 48 ( 1 ) page: 35 - 51   2022.1

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  8. Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer

    Matsuzawa Reiko, Morise Masahiro, Tanaka Ichidai, Hayai Shunsaku, Tamiya Yutaro, Koyama Junji, Hase Tetsunari, Wakahara Keiko, Kim Deoksu, Shimoyama Yoshie, Hashimoto Naozumi

    INTERNAL MEDICINE   Vol. 61 ( 5 ) page: 703 - 708   2022

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  9. Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis

    Nakahara Yoshio, Hashimoto Naozumi, Sakamoto Koji, Enomoto Atsushi, Adams Taylor S., Yokoi Toyoharu, Omote Norihito, Poli Sergio, Ando Akira, Wakahara Keiko, Suzuki Atsushi, Inoue Masahide, Hara Akitoshi, Mizutani Yasuyuki, Imaizumi Kazuyoshi, Kawabe Tsutomu, Rosas Ivan O., Takahashi Masahide, Kaminski Naftali, Hasegawa Yoshinori

    EUROPEAN RESPIRATORY JOURNAL   Vol. 58 ( 6 )   2021.12

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  10. A Pilot Study of Transbronchial Biopsy Using Endobronchial Ultrasonography with a Guide Sheath in the Diagnosis of Peripheral Pulmonary Lesions in Patients with Interstitial Lung Disease

    Ito Takayasu, Kimura Tomoki, Kataoka Kensuke, Okachi Shotaro, Wakahara Keiko, Hashimoto Naozumi, Kondoh Yasuhiro

    DIAGNOSTICS   Vol. 11 ( 12 )   2021.12

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  11. Endobronchial Ultrasonography with a Guide Sheath Transbronchial Biopsy for Diagnosing Peripheral Pulmonary Lesions within or near Fibrotic Lesions in Patients with Interstitial Lung Disease

    Ito Takayasu, Okachi Shotaro, Kimura Tomoki, Kataoka Kensuke, Suzuki Yasuhiko, Kinoshita Fumie, Wakahara Keiko, Hashimoto Naozumi, Kondoh Yasuhiro

    CANCERS   Vol. 13 ( 22 )   2021.11

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  12. Assessment of Extensive Airway Obstruction Using Point-by-Point Lateral Pressure Measurements during Bronchoscopy

    Nishine Hiroki, Hiramoto Takehiko, Handa Hiroshi, Inoue Takeo, Wakahara Keiko, Saka Hideo, Miyazawa Teruomi, Mineshita Masamichi

    RESPIRATION   Vol. 100 ( 7 ) page: 611 - 617   2021.7

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  13. Surgical strategy and optimal timing of tracheostomy in patients with COVID-19: Early experiences in Japan

    Nishio Naoki, Hiramatsu Mariko, Goto Yukari, Shindo Yuichiro, Yamamoto Takanori, Jingushi Naruhiro, Wakahara Keiko, Sone Michihiko

    AURIS NASUS LARYNX   Vol. 48 ( 3 ) page: 518 - 524   2021.6

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  14. The Importance of Appropriate Diagnosis in the Practical Management of Chronic Obstructive Pulmonary Disease

    Hashimoto Naozumi, Wakahara Keiko, Sakamoto Koji

    DIAGNOSTICS   Vol. 11 ( 4 )   2021.4

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  15. Efficacy of Omalizumab against Aspirin-hypersensitivity and Overproduction of Cysteinyl Leukotrienes in Aspirin-exacerbated Respiratory Disease: A Randomized Trial

    Hayashi Hiroaki, Fukutomi Yuma, Mitsui Chihiro, Kajiwara Keiichi, Watai Kentaro, Kamide Yosuke, Iwata Maki, Nagayama Kisako, Hamada Yuto, Tomita Yasuhiro, Sekiya Kiyoshi, Tsuburai Takahiro, Mori Akio, Izuhara Kenji, Wakahara Keiko, Hashimoto Naozumi, Hasegawa Yoshinori, Taniguchi Masami

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   Vol. 147 ( 2 ) page: AB56 - AB56   2021.2

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    Language:Japanese  

    Web of Science

  16. CERS6 required for cell migration and metastasis in lung cancer

    Suzuki Motoshi, Cao Ke, Kato Seiichi, Mizutani Naoki, Tanaka Kouji, Arima Chinatsu, Tai Mei Chee, Nakatani Norie, Yanagisawa Kiyoshi, Takeuchi Toshiyuki, Shi Hanxiao, Mizutani Yasuyoshi, Niimi Atsuko, Taniguchi Tetsuo, Fukui Takayuki, Yokoi Kohei, Wakahara Keiko, Hasegawa Yoshinori, Mizutani Yukiko, Iwaki Soichiro, Fujii Satoshi, Satou Akira, Tamiya-Koizumi Keiko, Murate Takashi, Kyogashima Mamoru, Tomida Shuta, Takahashi Takashi

    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE   Vol. 24 ( 20 ) page: 11949 - 11959   2020.10

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  17. Omalizumab for Aspirin-Hypersensitivity and Leukotriene Overproduction in Aspirin-Exacerbated Respiratory Disease: A Randomized Trial.

    Hayashi H, Fukutomi Y, Mitsui C, Kajiwara K, Watai K, Kamide Y, Nakamura Y, Hamada Y, Tomita Y, Sekiya K, Tsuburai T, Izuhara K, Wakahara K, Hashimoto N, Hasegawa Y, Taniguchi M

    American journal of respiratory and critical care medicine   Vol. 201 ( 12 ) page: 1488 - 1498   2020.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1164/rccm.201906-1215OC

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  18. Bronchial wall thickening is associated with severity of chronic rhinosinusitis

    Majima Suguru, Wakahara Keiko, Nishio Tomoko, Nishio Naoki, Teranishi Masaaki, Iwano Shingo, Hirakawa Akihiro, Hashimoto Naozumi, Sone Michihiko, Hasegawa Yoshinori

    RESPIRATORY MEDICINE   Vol. 170   page: 106024   2020

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  19. The Role of Meflin Expression in Fibroblasts During Development of Pulmonary Fibrosis

    Hashimoto N., Nakahara Y., Sakamoto K., Enomoto A., Yokoi T., Suzuki A., Inoue M., Wakahara K., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 201   2020

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    Language:Japanese  

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  20. BK virus-associated viruria and viremia in a patient with lymphangioleiomyomatosis after lung re-transplantation: A case report and review of the literature on BK virus infection post-lung transplantation

    Okumura Junya, Nakahara Yoshio, Nakaguro Masato, Shindo Yuichiro, Hase Tetsunari, Wakahara Keiko, Hashimoto Naozumi, Hasegawa Yoshinori

    JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 25 ( 10 ) page: 820 - 824   2019.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2019.04.002

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  21. Mixed cell type in airway inflammation is the dominant phenotype in asthma patients with severe chronic rhinosinusitis

    Nishio Tomoko, Wakahara Keiko, Suzuki Yoshihiro, Nishio Naoki, Majima Suguru, Nakamura Saya, Teranishi Masaaki, Nakatochi Masahiro, Sone Michihiko, Hasegawa Yoshinori

    ALLERGOLOGY INTERNATIONAL   Vol. 68 ( 4 ) page: 515 - 520   2019.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.alit.2019.05.004

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  22. Relationship of Physical Activity Level with Musculoskeletal Conditions and Inflammation in COPD Patients Without Comorbidities

    Majima S., Wakahara K., Nishio T., Nakamura S., Sashio T., Asano S., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 199   page: .   2019

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  23. Airway Basophils Are Activated and Associated with Eosinophilic Inflammation in Asthmatic Patients

    Suzuki Yoshihiro, Wakahara Keiko, Nishio Tomoko, Ito Satoru, Hasegawa Yoshinori

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   Vol. 137 ( 2 ) page: AB77 - AB77   2016.2

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    Language:Japanese  

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  24. Antineutrophil Cytoplasmic Antibody-associated Vasculitis Superimposed on Infection-related Glomerulonephritis Secondary to Pulmonary Mycobacterium avium Complex Infection. Reviewed

    Asano S, Mizuno S, Okachi S, Aso H, Wakahara K, Hashimoto N, Ito S, Kozaki Y, KatsunoT, Maruyama S, Hasegawa Y

    Intern Med.   Vol. 55 ( 13 ) page: 1705 - 1712   2016

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  25. Antineutrophil Cytoplasmic Antibody-associated Vasculitis Superimposed on Infection-related Glomerulonephritis Secondary to Pulmonary Mycobacterium avium Complex Infection

    Asano Shuichi, Mizuno Shige, Okachi Shotaro, Aso Hiromichi, Wakahara Keiko, Hashimoto Naozumi, Ito Satoru, Kozaki Yohei, Katsuno Takayuki, Maruyama Shoichi, Hasegawa Yoshinori

    INTERNAL MEDICINE   Vol. 55 ( 17 ) page: 2439 - 2445   2016

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  26. Airway basophils are increased and correlated with eosinophilic inflammtaion in asthma and COPD

    Wakahara Keiko, Suzuki Yoshihiro, Shiraki Akira, Sashio Toyokazu, Abe Takashi, Arakawa Yukari, Goto Daiki, Shindoh Joe, Hasegawa Yoshinori

    EUROPEAN RESPIRATORY JOURNAL   Vol. 46   2015.9

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  27. Massive mediastinal cryptococcosis in a young immunocompetent patient.

    Okachi S, Wakahara K, Kato D, Umeyama T, Yagi T, Hasegawa Y

    Respirology case reports   Vol. 3 ( 3 ) page: 95 - 8   2015.9

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    DOI: 10.1002/rcr2.111

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  28. Basophils increase in Crohn disease and ulcerative colitis and favor mesenteric lymph node memory T(H)17/T(H)1 response

    Chapuy Laurence, Bsat Marwa, Mehta Heena, Rubio Manuel, Wakahara Keiko, Van Vu Quang, Baba Nobuyasu, Cheong Cheolho, Yun Tae Jin, Panzini Benoit, Wassef Ramses, Richard Carole, Tamaz Raja, Soucy Genevieve, Delespesse Guy, Sarfati Marika

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   Vol. 134 ( 4 ) page: 978 - 981   2014.10

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  29. USEFULNESS AND SAFETY OF ENDOBRONCHIAL ULTRASOUND-GUIDED TRANSBRONCHIAL NEEDLE ASPIRATION IN OLDER PATIENTS

    Okachi Shotaro, Imai Naoyuki, Imaizumi Kazuyoshi, Hase Tetsunari, Aso Hiromichi, Wakahara Keiko, Ito Satoru, Hashimoto Naozumi, Sato Mitsuo, Kondo Masashi, Hasegawa Yoshinori

    RESPIROLOGY   Vol. 18   page: 168 - 168   2013.11

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  30. Endobronchial ultrasound transbronchial needle aspiration in older people

    Okachi Shotaro, Imai Naoyuki, Imaizumi Kazuyoshi, Hase Tetsunari, Shindo Yuichiro, Sakamoto Koji, Aso Hiromichi, Wakahara Keiko, Hashimoto Izumi, Ito Satoru, Hashimoto Naozumi, Sato Mitsuo, Kondo Masashi, Hasegawa Yoshinori

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 13 ( 4 ) page: 986 - 992   2013.10

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  31. CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF.

    Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M

    The Journal of experimental medicine   Vol. 210 ( 6 ) page: 1251 - 63   2013.6

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    DOI: 10.1084/jem.20122037

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  32. CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.

    Van VQ, Raymond M, Baba N, Rubio M, Wakahara K, Susin SA, Sarfati M

    Journal of immunology (Baltimore, Md. : 1950)   Vol. 188 ( 9 ) page: 4249 - 55   2012.5

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    DOI: 10.4049/jimmunol.1102702

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  33. CD47(low) status on CD4 effectors is necessary for the contraction/resolution of the immune response in humans and mice.

    Van VQ, Baba N, Rubio M, Wakahara K, Panzini B, Richard C, Soucy G, Franchimont D, Fortin G, Torres AC, Cabon L, Susin S, Sarfati M

    PloS one   Vol. 7 ( 8 ) page: e41972   2012

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    DOI: 10.1371/journal.pone.0041972

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  34. Lung dendritic cells induce T(H)17 cells that produce T(H)2 cytokines, express GATA-3, and promote airway inflammation.

    Raymond M, Van VQ, Wakahara K, Rubio M, Sarfati M

    The Journal of allergy and clinical immunology   Vol. 128 ( 1 ) page: 192 - 201.e6   2011.7

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    DOI: 10.1016/j.jaci.2011.04.029

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  35. Effect of Diesel Exhaust Particles on House Dust Mite-Induced Airway Eosinophilic Inflammation and Remodeling in Mice

    Takahashi Go, Tanaka Hiroyuki, Wakahara Keiko, Nasu Reishi, Hashimoto Mikiko, Miyoshi Kosuke, Takano Hirohisa, Yamashita Hirotaka, Inagaki Naoki, Nagai Hiroichi

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 112 ( 2 ) page: 192 - 202   2010.2

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  36. Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma.

    Ishizaki M, Tanaka H, Kajiwara D, Toyohara T, Wakahara K, Inagaki N, Nagai H

    Journal of pharmacological sciences   Vol. 108 ( 3 ) page: 355 - 63   2008.11

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    DOI: 10.1254/jphs.08162fp

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  37. Repeated instillations of Dermatophagoides farinae into the airways can induce Th2-dependent airway hyperresponsiveness, eosinophilia and remodeling in mice - Effect of intratracheal treatment of fluticasone propionate

    Wakahara Keiko, Tanaka Hiroyuki, Takahashi Go, Tarnari Mayurni, Nasu Reishi, Toyohara Tatsuyuki, Takano Hirohisa, Salto Saburo, Inagaki Naoki, Shimokata Kaoru, Nagai Hiroichi

    EUROPEAN JOURNAL OF PHARMACOLOGY   Vol. 578 ( 1 ) page: 87 - 96   2008.1

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  38. Immunomodulatory effects of CpG oligodeoxynucleotides on house dust mite-induced airway inflammation in mice

    Hirose Izumi, Tanaka Hiroyuki, Takahashi Go, Wakahara Keiko, Tamari Mayumi, Sakamoto Tatsuo, Kojima Seiji, Inagaki Naoki, Nagai Hiroichi

    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY   Vol. 147 ( 1 ) page: 6 - 16   2008

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  39. Unusual presentation of recurrent follicular lymphoma as diffuse granular shadow

    Ito Takayasu, Okachi Shotaro, Ishikawa Yuichi, Shimada Satoko, Wakahara Keiko, Hashimoto Naozumi

    RESPIROLOGY CASE REPORTS   Vol. 9 ( 3 ) page: e00710   2021.3

  40. Endobronchial ultrasound-guided transbronchial needle aspiration under non-invasive positive pressure for the diagnosis of lung metastasis due to renal cell carcinoma in a patient with respiratory failure.

    Ito T, Okachi S, Ikenouchi T, Ushijima F, Ohashi T, Ogawa M, Nagahama M, Wakahara K, Hashimoto N

    Respiratory medicine case reports   Vol. 29   page: 101028   2020

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    DOI: 10.1016/j.rmcr.2020.101028

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  41. Longitudinal changes in pulmonary function and respiratory impedance of rheumatoid arthritis.

    Isobe Y, Ito S, Matsuda T, Iwano S, Uchida A, Takahashi N, Kojima T, Wakahara K, Yamaguchi E, Hasegawa Y

    Respiratory physiology & neurobiology   Vol. 261   page: 1 - 8   2019.3

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    DOI: 10.1016/j.resp.2018.12.008

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  42. Mixed cellular inflammation is increased in adult asthma with severe chronic rhinosinusitis

    Nishio Tomoko, Wakahara Keiko, Suzuki Yoshihiro, Majima Suguru, Nishio Naoki, Teranishi Masaaki, Sone Michihiko, Hasegawa Yoshinori

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   Vol. 143 ( 2 ) page: AB189 - AB189   2019.2

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  43. Increasing sputum basophils is a marker for eosinophil-dominant airway inflammation in adult asthma

    Wakahara Keiko, Nishio Tomoko, Suzuki Yoshihiro, Majima Suguru, Nakamura Saya, Hasegawa Yoshinori

    EUROPEAN RESPIRATORY JOURNAL   Vol. 52   2018.9

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    DOI: 10.1183/13993003.congress-2018.PA4425

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  44. Periostin levels in chronic obstructive pulmonary disease (COPD)

    Nakamura Saya, Wakahara Keiko, Majima Suguru, Nisio Tomoko, Suzuki Yoshihiro, Shiraki Akira, Abe Takashi, Shindoh Joe, Sashio Toyokazu, Ono Junya, Izuhara Kenji, Hasegawa Yoshinori

    EUROPEAN RESPIRATORY JOURNAL   Vol. 52   2018.9

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    DOI: 10.1183/13993003.congress-2018.PA1074

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  45. Lung Metastases from Bile Duct Adenocarcinoma Mimicking Chronic Airway Infection and Causing Diagnostic Difficulty

    Sato Mitsuo, Okachi Shotaro, Fukihara Jun, Shimoyama Yoshie, Wakahara Keiko, Sakakibara Toshihiro, Hase Tetsunari, Onishi Yasuharu, Ogura Yasuhiro, Maeda Osamu, Hasegawa Yoshinori

    INTERNAL MEDICINE   Vol. 57 ( 10 ) page: 1429 - 1432   2018

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    DOI: 10.2169/internalmedicine.9718-17

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  46. Pseudomembranous Invasive Tracheobronchial Aspergillosis with Fulminant Hepatitis and Hemophagocytic Syndrome

    Majima Suguru, Okachi Shotaro, Asano Motoyo, Wakahara Keiko, Hashimoto Naozumi, Sato Mitsuo, Ishigami Masatoshi, Hasegawa Yoshinori

    INTERNAL MEDICINE   Vol. 57 ( 16 ) page: 2371 - 2375   2018

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    DOI: 10.2169/internalmedicine.9673-17

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  47. FLOW CYTOMETRIC ANALYSIS OF INDUCED SPUTUM TO EVALUATE EOSINOPHILIC INFLAMMATION

    Wakahara Keiko, Suzuki Yoshihiro, Nishio Tomoko, Majima Suguru, Hasegawa Yoshinori

    RESPIROLOGY   Vol. 22   page: 94-95   2017.11

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  48. MEASUREMENT OF AIRWAY DIMENSIONS BY 3-D CT IN INFLAMMATORY BOWEL DISEASE PATIENTS

    Majima Suguru, Wakahara Keiko, Nishio Tomoko, Hasegawa Yoshinori

    RESPIROLOGY   Vol. 22   page: 25-25   2017.11

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  49. Airway basophils are increased and activated in eosinophilic asthma

    Suzuki Y., Wakahara K., Nishio T., Ito S., Hasegawa Y.

    ALLERGY   Vol. 72 ( 10 ) page: 1532-1539   2017.10

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    DOI: 10.1111/all.13197

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  50. Two cases of autoimmune pulmonary alveolar proteinosis with rheumatoid arthritis

    Ito Satoru, Wakahara Keiko, Kojima Toshihisa, Takahashi Nobunori, Nishiwaki Kimitoshi, Yamaguchi Etsuro, Hasegawa Yoshinori

    ALLERGOLOGY INTERNATIONAL   Vol. 66 ( 3 ) page: 507 - 509   2017.7

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    DOI: 10.1016/j.alit.2017.02.002

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  51. Factors Affecting the Diagnostic Yield of Transbronchial Biopsy Using Endobronchial Ultrasonography with a Guide Sheath in Peripheral Lung Cancer Reviewed

    Okachi S, Imai N, Imaizumi K, Iwano S, Ando M, Hase T, Aso H, Morise M, Wakahara K, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y.

    Intern Med   Vol. 55 ( 17 ) page: 2439-2445   2016.7

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    DOI: 10.2169/internalmedicine.55.6341.

  52. Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells. Reviewed

    Suzuki M, Cao K, Kato S, Komizu Y, Mizutani N, Tanaka K, Arima C, Tai MC, Yanagisawa K, Togawa N, Shiraishi T, Usami N, Taniguchi T, Fukui T, Yokoi K, Wakahara K, Hasegawa Y, Mizutani Y, Igarashi Y, Inokuchi J, Iwaki S, Fujii S, Satou A, Matsumoto Y, Ueoka R, Tamiya-Koizumi K, Murate T, Nakamura M, Kyogashima M, Takahashi T

    J Clin Invest.   Vol. 126 ( 1 ) page: 254-265   2016.1

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  53. Two cases of autoimmune pulmonary alveolar proteinosis with rheumatoid arthritis. Reviewed

    Ito S, Wakahara K, Kojima T, Takahashi N, Nishiwaki K, Yamaguchi E, Hasegawa Y.

    Allergol Int.   Vol. 66 ( 3 ) page: 507-509   2016

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    DOI: doi:10.1016/j.alit.2017.02.002.

  54. Massive mediastinal cryptococcosis in young immunocompetent patient. Reviewed

    Okachi S, Wakahara K, Kato D, Umeyama T, Yagi T, Hasegawa Y

    Respirol Case Rep.   Vol. 3 ( 3 ) page: 95   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  55. Endobronchial ultrasound transbronchial needle aspiration in older people. Reviewed

    Okachi S, Imai N, Imaizumi K, Hase T, Shindo Y, Sakamoto K, Aso H, Wakahara K, Hashimoto I, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y.

    Geriatr Gerontol Int.   Vol. 13 ( 4 ) page: 986-992   2013.10

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  56. CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1b and TNF. Reviewed

    Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, SchakelK, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M

    J Exp Med.   Vol. 210 ( 6 ) page: 1251-1263   2013.6

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  57. CD47Low Status on CD4 Effectors Is Necessary for the Contraction/Resolution of the Immune Response in Humans and Mice.

    Van VQ, Baba N, Rubio M, Wakahara K, Panzini B, Richard C, Soucy G, Franchimont D, Fortin G, Torres AC, Cabon L, Susin S, Sarfati M

    PLoS One   Vol. 7 ( 8 ) page: e41972   2012.7

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  58. CD47high expression on CD4 effectors identifies functional long-lived memory T cell progenitors.

    Van VQ, Raymond M, Baba N, Rubio M, Wakahara K, Susin A.S, Sarfati M

    J Immunol.   Vol. 188   page: 4249-4255   2012

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  59. Lung dendritic cells induce TH17 cells that produce TH2 cytokines, express GATA3, and promote airway inflammation.

    Raymond M, Van VQ, Wakahara K, Rubio M, Sarfati M

      Vol. 128 ( 1 ) page: 192-201   2011.7

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  60. Effect of diesel exhaust particles on house dust mite-induced airway eosinophilic inflammation and remodeling.

    Takahashi G, Tanaka H, Wakahara K, Nasu R, Hashimoto M, Miyoshi K, Takano H, Yamashita H, Inagaki N, Nagai H

    J Pharmacol Sci   Vol. 112 ( 2 ) page: 192-202   2010.2

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  61. Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma.

    Ishizaki M, Tanaka H, Kajiwara D, Toyohara T, Wakahara K, Inagaki N, Nagai H

    J Pharmacol Sci   Vol. 108 ( 3 ) page: 355-363   2008.11

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  62. Repeated instillations of Dermatophagoides farinae into the airways can induce Th2-dependent airway hyperresponsiveness, eosinophilia and remodeling in mice: effect of intratracheal treatment of fluticasone propionate.

    Wakahara K, Tanaka H, Takahashi G, Tamari M, Nasu R, Toyohara T, Takano H, Saito S, Inagaki N, Shimokata K, Nagai H

    Eur J Pharmacol.   Vol. 578 ( 1 ) page: 87-96   2008.1

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  63. Immunomodulatory effects of CpG oligodeoxynucleotides on house dust mite-induced airway inflammation in mice.

    Hirose I, Tanaka H, Takahashi G, Wakahara K, Tamari M, Sakamoto T, Kojima S, Inagaki N, Nagai H

    Int Arch Allergy Immunol.   Vol. 147 ( 1 ) page: 6-16   2008.1

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KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 間質性肺炎急性増悪病態における新規病的微小環境因子・ミトコンドリアDNAの役割

    Grant number:21K08202  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    阪本 考司, 芳川 豊史, 若原 恵子, 橋本 直純, 猪股 弥生

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    特発性肺線維症(IPF)は中高年に発症する進行性難治性の肺疾患である。急性増悪はIPF患者の約4割に突然発症する死亡率の高い合併症であるが、原因が分かっておらず発症の予測や治療法の開発が進んでいない。我々は最近、IPF患者さんの体液中のミトコンドリアDNAの増加が急性増悪の発症を予測しうることを発見した。これにヒントを得た本研究は、急性増悪発症のメカニズムとして肺に存在するマクロファージの異常活性化とミトコンドリアの代謝異常が関与していると仮定して、新たに急性増悪の動物モデルを作成し治療標的と診断法の開発を目指します。

  2. 好塩基球を介した2型炎症調節機構の解明ーアレルギー性・好酸球性肺疾患と肺恒常性

    Grant number:21K08456  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    若原 恵子, 阪本 考司, 橋本 直純

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    本研究では、2型炎症が創傷治癒と恒常性維持、アレルギー・好酸球性疾患の正・負の両面に関わっていることに注目し、そのコントロールを行っている細胞が好塩基球であるという仮説のもと、好塩基球のフェノタイプ(病原性・非病原性)を探索すること、フェノタイプを調節する因子を探ることを目的としている。特に呼吸器疾患に注目し、肺・気道における好塩基球の役割について検討を行う。

  3. Immune-pathological diagnostic artificial intelligence development research for pulmonary fibrosis using fibrotic foci-specific enhanced micro-CT

    Grant number:20K21599  2020.7 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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  4. Basophils as potential refractory factors and biomarkers for chronic airway inflammation

    Grant number:18K08173  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Wakahara Keiko

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    Basophils are rare cells, accounting for less than 1% of the blood, but they have high potential for producing potent cytokines and chemical mediators. In this study, we investigated the potential of basophils as refractory factors and biomarkers in chronic refractory airway inflammatory diseases.
    In bronchial asthma, there was a positive correlation between the number of sputum basophils and the number of sputum eosinophils, and basophils were increased in eosinophilic inflammatory phenotypes (more than 2% eosinophils and less than 60% neutrophils). Basophilic inflammation was also found in COPD and airway diseases in rheumatoid arthritis, but it was not associated with exhaled nitric oxide concentration or IgE level, suggesting a different mechanism from that of asthma.

  5. Identification of cancer initiating cell factors and an attempt of drug development

    Grant number:26670625  2014.4 - 2016.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    SUZUKI Motoshi, FUKUI Takayuki, WAKAHARA Keiko, KATO Sei-ichi, Nishida Atsushi

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    We collected clinical lung cancer specimens and transplanted each of in the immune-deficient mice. Xenografts were recovered after tumor formation, collagenase-treated, and sorted for CD166 positive population. In a cell line, the CD166 positive cells successfully formed secondary tumors in mice. We performed database analysis to figure out a gene candidate which may contribute to the cancer initiating cell nature. By using the above cell line, we established a stable cell line that is associated with a knockdown of this gene, and inoculated thousands of cells in mice. Results are forthcoming. We also screened for an inhibitor against this gene product. Among the 2000 candidates, we found a compound that inhibits the activity. To decrease the EC50 value, we started optimization of this compound.

  6. Analysis of bronchial asthma onset/exacerbation mechanism based on inflammatory dendritic cells and basophils.

    Grant number:15K09549  2015.4 - 2018.3

    Wakahara Keiko

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    Authorship:Principal investigator 

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    To analyze the role of inflammatory dendritic cells and basophils as bronchial asthma onset and exacerbation factors, we performed following studies using induced sputum from asthmatic patients. 1) Establishment of induced sputum analysis by flow cytometry, 2) Analysis of inflammatory dendritic cells and basophils in induced sputum, 3) Phenotype identification of sputum basophils, 4) Relationship between sputum basophils and clinical phenotype in adult asthma.
    The numbers of inflammatory dendritic cells and basophils in induced sputum were increased in adult asthmatic patients compared with those in normal controls. The number of sputum basophils was positively correlated with the number of sputum eosinophils. Furthermore, sputum basophils were activated compared with blood basophils from same patients. These observations suggest that basophils could be exacerbation factors of eosinophilic asthma.

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Teaching Experience (On-campus) 12

  1. 難治性呼吸器疾患の克服に向けて 難治性喘息に対する分子標的薬の進歩

    2020

  2. 呼吸器アレルギー疾患

    2020

  3. 呼吸器アレルギー疾患

    2019

  4. 呼吸器アレルギー疾患

    2018

  5. 呼吸器アレルギー疾患

    2017

  6. 呼吸器内科PBL解説

    2017

  7. 呼吸器内科PBL解説

    2016

  8. 呼吸器アレルギー疾患

    2016

  9. 呼吸器内科PBL解説

    2015

  10. 呼吸器アレルギー疾患

    2015

  11. 呼吸器内科PBL解説

    2014

  12. 医療現場における意思決定プロセス

    2014

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