Updated on 2022/03/30

写真a

 
KAMIYA Yukiko
 
Organization
Graduate School of Engineering Biomolecular Engineering 1 Associate professor
Graduate School
Graduate School of Engineering
Undergraduate School
School of Engineering Chemistry and Biotechnology
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 博士(薬学) ( 2008.3   名古屋市立大学 ) 

Research Interests 12

  1. 結晶構造解析

  2. 細胞内輸送

  3. oligosaccharide

  4. 核酸医薬

  5. 核酸化学

  6. quality control

  7. Lectin

  8. siRNA

  9. RNA結合タンパク質

  10. RNAi

  11. NMR

  12. miRNA

Research Areas 7

  1. Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules  / 核酸, タンパク質

  2. Life Science / Pharmaceutical hygiene and biochemistry

  3. Nanotechnology/Materials / Bio chemistry  / Bio-functional chemistry

  4. Life Science / Structural biochemistry

  5. Nanotechnology/Materials / Chemical biology  / Chemical biology

  6. Life Science / Pharmaceutical chemistry and drug development sciences  / 核酸医薬

  7. Life Science / Pharmaceutical analytical chemistry and physicochemistry  / 核酸, タンパク質

▼display all

Current Research Project and SDGs 2

  1. 機能性核酸を用いたRNAi機構の分子基盤の解明

  2. 核酸医薬開発

Research History 7

  1. Nagoya University   Graduate School of Engineering Biomolecular Engineering 1   Associate professor

    2017.4

  2. Nagoya University   Graduate School of Engineering Department of Molecular Design and Engineering Organic Materials Design and Engineering   Associate professor

    2016.4 - 2017.3

  3. Nagoya University   Lecturer

    2015.10 - 2016.3

  4. Nagoya University   Lecturer

    2013.4 - 2015.9

  5. Nagoya University   Assistant Professor

    2012.1 - 2013.3

  6. 自然科学研究機構 分子科学研究所   特任助教

    2009.4 - 2011.12

      More details

    Country:Japan

  7. 自然科学研究機構 分子科学研究所   研究員

    2008.4 - 2009.3

      More details

    Country:Japan

▼display all

Education 2

  1. Nagoya City University   Graduate School, Division of Pharmaceutical Sciences

    2005.4 - 2008.3

      More details

    Country: Japan

  2. Nagoya City University   Faculty of Pharmaceutical Science

    - 2003.3

      More details

    Country: Japan

Professional Memberships 16

  1. 日本化学会

  2. 高分子学会

  3. 日本薬学会

  4. タンパク質科学会

  5. NMR討論会

  6. 糖質学会

  7. 生化学会

  8. 日本核酸医薬学会

  9. タンパク質科学会

  10. NMR討論会

  11. 日本化学会

  12. 糖質学会

  13. 生化学会

  14. 日本薬学会

  15. 日本核酸医薬学会

  16. 日本核酸化学会

▼display all

Awards 7

  1. 名古屋大学 令和元年度「女性研究者トップリーダー顕彰」

    2019   名古屋大学  

     More details

    Country:Japan

  2. 日本化学会第94春季年会 優秀講演賞

    2014.4   日本化学会  

     More details

    Country:Japan

  3. 第23回バイオ・高分子シンポジウム 若手研究者奨励講演賞

    2013.7   高分子学会 バイオ・高分子研究会  

     More details

    Country:Japan

  4. 第77回日本生化学会中部支部例会 日本生化学会中部支部奨励賞

    2013.5   日本生化学会中部支部  

     More details

    Country:Japan

  5. 糖鎖科学名古屋拠点 若手奨励賞

    2010.3   糖鎖科学名古屋拠点  

     More details

    Country:Japan

  6. 特定領域研究「タンパク質の社会」平成20年度全体班会議 ポスター優秀賞

    2008   特定領域研究「タンパク質の社会」  

     More details

    Country:Japan

  7. 日米合同糖質会議 ポスター賞

    2004   日本糖質学会  

     More details

    Country:Japan

▼display all

 

Papers 61

  1. Xeno nucleic acids (XNAs) having non-ribose scaffolds with unique supramolecular properties

    Asanuma Hiroyuki, Kamiya Yukiko, Kashida Hiromu, Murayama Keiji

    CHEMICAL COMMUNICATIONS     2022.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d1cc05868a

    Web of Science

    PubMed

  2. Development and Modification of Pre-miRNAs with a FRET Dye Pair for the Intracellular Visualization of Processing Intermediates That Are Generated in Cells. Reviewed International journal

    Yukiko Kamiya, Hiroshi Kamimoto, Hongyu Zhu, Hiroyuki Asanuma

    Sensors (Basel, Switzerland)   Vol. 21 ( 5 )   2021.3

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    microRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs), which regulate gene expression via the RNA interference (RNAi) system. miRNAs have attracted enormous interest because of their biological significance and disease relationship. In cell systems, the generation of miRNA is regulated by multiple steps: the transfer of primary miRNA from the nucleus to the cytosol, the generation of the precursor-miRNA (pre-miRNA), the production of double-stranded RNA from pre-miRNA by the Dicer, the interaction with protein argonaute-2 (AGO2), and the subsequent release of one strand to form miRISC with AGO2. In this study, we attempt to visualize the intermediates that were generated in the miRNA-maturation step in the cells to acquire a detailed understanding of the maturation process of miRNA. To achieve this, we developed pre-miRNAs labeling with a Dicer- or AGO2-responsible fluorescence resonance energy transfer (FRET) dye pair. We observed that modifications with the dye at suitable positions did not interfere with the biological activities of pre-miRNAs. Further, imaging analyses employing these pre-miRNAs demonstrated that the processing of pre-miRNA promoted the accumulation of miRNA at the specific foci in the cytosol. The FRET-labeled pre-miRNA would further elucidate the mechanisms of the RNAi process and provide the basis for development of nucleic acid drugs working in the RNAi system.

    DOI: 10.3390/s21051785

    Web of Science

    PubMed

  3. Investigation of Strand-Selective Interaction of SNA-Modified siRNA with AGO2-MID. Reviewed International journal

    Yukiko Kamiya, Yuuki Takeyama, Tomonari Mizuno, Fuminori Satoh, Hiroyuki Asanuma

    International journal of molecular sciences   Vol. 21 ( 15 )   2020.8

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Small interfering RNA (siRNA) has been recognized as a powerful gene-silencing tool. For therapeutic application, chemical modification is often required to improve the properties of siRNA, including its nuclease resistance, activity, off-target effects, and tissue distribution. Careful siRNA guide strand selection in the RNA-induced silencing complex (RISC) is important to increase the RNA interference (RNAi) activity as well as to reduce off-target effects. The passenger strand-mediated off-target activity was previously reduced and on-target activity was enhanced by substitution with acyclic artificial nucleic acid, namely serinol nucleic acid (SNA). In the present study, the reduction of off-target activity caused by the passenger strand was investigated by modifying siRNAs with SNA. The interactions of SNA-substituted mononucleotides, dinucleotides, and (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO)-labeled double-stranded RNA (dsRNA) with the MID domain of the Argonaute 2 (AGO2) protein, which plays a pivotal role in strand selection by accommodation of the 5'-terminus of siRNA, were comprehensively analyzed. The obtained nuclear magnetic resonance (NMR) data revealed that AGO2-MID selectively bound to the guide strand of siRNA due to the inhibitory effect of the SNA backbone located at the 5' end of the passenger strand.

    DOI: 10.3390/ijms21155218

    Web of Science

    PubMed

  4. Incorporation of Pseudo-complementary Bases 2,6-Diaminopurine and 2-Thiouracil into Serinol Nucleic Acid (SNA) to Promote SNA/RNA Hybridization. Reviewed International journal

    Yukiko Kamiya, Fuminori Sato, Keiji Murayama, Atsuji Kodama, Susumu Uchiyama, Hiroyuki Asanuma

    Chemistry, an Asian journal   Vol. 15 ( 8 ) page: 1266 - 1271   2020.4

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Serinol nucleic acid (SNA) is a promising candidate for nucleic acid-based molecular probes and drugs due to its high affinity for RNA. Our previous work revealed that incorporation of 2,6-diaminpurine (D), which can form three hydrogen bonds with uracil, into SNA increases the melting temperature of SNA-RNA duplexes. However, D incorporation into short self-complementary regions of SNA promoted self-dimerization and hindered hybridization with RNA. Here we synthesized a SNA monomer of 2-thiouracil (sU), which was expected to inhibit base pairing with D by steric hindrance between sulfur and the amino group. To prepare the SNA containing D and sU in high yield, we customized the protecting groups on D and sU monomers that can be readily deprotected under acidic conditions. Incorporation of D and sU into SNA facilitated stable duplex formation with target RNA by suppressing the self-hybridization of SNA and increasing the stability of the heteroduplex of SNA and its complementary RNA. Our results have important implications for the development of SNA-based probes and nucleic acid drugs.

    DOI: 10.1002/asia.201901728

    Web of Science

    PubMed

  5. Development of Visible-Light-Responsive RNA Scissors Based on a 10–23 DNAzyme Reviewed International journal

    Yukiko Kamiya, Yu Arimura, Hideaki Ooi, Kenjiro Kato, Xing-Guo Liang, Hiroyuki Asanuma

    ChemBioChem   Vol. 19 ( 12 ) page: 1305 - 1311   2018.6

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley-VCH Verlag  

    The 10–23 DNAzyme is an artificially developed functional oligonucleotide that can cleave RNA in a sequence-specific manner. In this study, we designed a new photo-driven DNAzyme incorporating a photoresponsive DNA overhang complementary to the catalytic core region. The photoresponsive overhang region of the DNAzyme included either azobenzene components (Azos) or 2,6-dimethyl-4-(methylthio)azobenzene units (SDM-Azos) each attached to a d-threoninol linker. When the Azos or SDM-Azos were in the trans form, the photoresponsive DNA overhang hybridized with the DNAzyme, and the RNA cleavage activity was suppressed. cis Isomerization of Azos or SDM-Azos, induced by 365 or 400 nm light, respectively, destabilized the duplex between the photoresponsive overhang and the catalytic core, and the DNAzyme recovered RNA cleavage activity. Reversible photoswitching of the DNAzyme activity was achieved by use of specific light irradiation. Further, light-dependent photoswitching of protein expression in the presence of the DNAzyme was demonstrated. Thus, this photo-driven DNAzyme has potential for application as a photocontrolled gene silencing system and a photoactivatable gene expression system.

    DOI: 10.1002/cbic.201800020

    Web of Science

    Scopus

    PubMed

  6. DNA Microcapsule for Photo-Triggered Drug Release Systems Reviewed International journal

    Yukiko Kamiya, Yoshinobu Yamada, Takahiro Muro, Kazunori Matsuura, Hiroyuki Asanuma

    CHEMMEDCHEM   Vol. 12 ( 24 ) page: 2016 - 2021   2017.12

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-V C H VERLAG GMBH  

    In this study we constructed spherical photo-responsive microcapsules composed of three photo-switchable DNA strands. These strands first formed a three-way junction (TWJ) motif that further self-assembled to form microspheres through hybridization of the sticky-end regions of each branch. To serve as the photo-switch, multiple unmodified azobenzene (Azo) or 2,6-dimethyl-4-(methylthio)azobenzene (SDM-Azo) were introduced into the sticky-end regions via a d-threoninol linker. The DNA capsule structure deformed upon trans-to-cis isomerization of Azo or SDM-Azo induced by specific light irradiation. In addition, photo-triggered release of encapsulated small molecules from the DNA microcapsule was successfully achieved. Moreover, we demonstrated that photo-triggered release of doxorubicin caused cytotoxicity to cultured cells. This biocompatible photo-responsive microcapsule has potential application as a photo-controlled drug-release system.

    DOI: 10.1002/cmdc.201700512

    Web of Science

    PubMed

  7. Introduction of 2,6-Diaminopurines into Serinol Nucleic Acid Improves Anti-miRNA Performance Reviewed International journal

    Yukiko Kamiya, Yuka Donoshita, Hiroshi Kamimoto, Keiji Murayama, Jumpei Ariyoshi, Hiroyuki Asanuma

    CHEMBIOCHEM   Vol. 18 ( 19 ) page: 1917 - 1922   2017.10

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-V C H VERLAG GMBH  

    MicroRNAs (miRNAs) are endogenous small RNAs that regulate gene expression at the post-transcriptional level by sequence-specific hybridisation. Anti-miRNA oligonucleotides (AMOs) are inhibitors of miRNA activity. Chemical modification of AMOs is required to increase binding affinity and stability in serum and cells. In this study, we synthesised AMOs with our original acyclic nucleic acid, serinol nucleic acid (SNA), backbone and with the artificial nucleobase 2,6-diaminopurine. The AMO composed of only SNA had strong nuclease resistance and blocked endogenous miRNA activity. A significant improvement in anti-miRNA activity of the AMO was achieved by introduction of a 2,6-diaminopurine residues into the SNA backbone. In addition, we found that the enhancement in AMO activity depended on the position of the 2,6-diaminopurine residue in the sequence. The high potency of the SNA-AMOs suggests that these oligomers will be useful as therapeutic reagents for control of miRNA function in patients and as tools for investigating the roles of microRNAs in cells.

    DOI: 10.1002/cbic.201700272

    Web of Science

    PubMed

  8. 光駆動型DNAナノマシン Invited

    浅沼浩之, 村山恵司, 神谷由紀子, 樫田啓

    高分子   Vol. 70   page: 550 - 552   2021.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  9. Intrastrand backbone-nucleobase interactions stabilize unwound right-handed helical structures of heteroduplexes of L-aTNA/RNA and SNA/RNA Reviewed International journal

    Yukiko Kamiya, Tadashi Satoh, Atsuji Kodama, Tatsuya Suzuki, Keiji Murayama, Hiromu Kashida, Susumu Uchiyama, Koichi Kato, Hiroyuki Asanuma

    Communications Chemistry   Vol. 3 ( 1 )   2020.11

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    <title>Abstract</title>
    Xeno nucleic acids, which are synthetic analogues of natural nucleic acids, have potential for use in nucleic acid drugs and as orthogonal genetic biopolymers and prebiotic precursors. Although few acyclic nucleic acids can stably bind to RNA and DNA, serinol nucleic acid (SNA) and L-threoninol nucleic acid (L-<italic>a</italic>TNA) stably bind to them. Here we disclose crystal structures of RNA hybridizing with SNA and with L-<italic>a</italic>TNA. The heteroduplexes show unwound right-handed helical structures. Unlike canonical A-type duplexes, the base pairs in the heteroduplexes align perpendicularly to the helical axes, and consequently helical pitches are large. The unwound helical structures originate from interactions between nucleobases and neighbouring backbones of L-<italic>a</italic>TNA and SNA through CH–O bonds. In addition, SNA and L-<italic>a</italic>TNA form a triplex structure via C:G*G parallel Hoogsteen interactions with RNA. The unique structural features of the RNA-recognizing mode of L-<italic>a</italic>TNA and SNA should prove useful in nanotechnology, biotechnology, and basic research into prebiotic chemistry.

    DOI: 10.1038/s42004-020-00400-2

    Web of Science

    Other Link: http://www.nature.com/articles/s42004-020-00400-2

  10. A triplex-forming linear probe for sequence-specific detection of duplex DNA with high sensitivity and affinity International journal

    Chen Yanglingzhi, Murayama Keiji, Kashida Hiromu, Kamiya Yukiko, Asanuma Hiroyuki

    CHEMICAL COMMUNICATIONS   Vol. 56 ( 40 ) page: 5358 - 5361   2020.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d0cc01865a

    Web of Science

    PubMed

  11. Designer Biopolymers: Self-Assembling Proteins and Nucleic Acids International journal

    Sugawara-Narutaki Ayae, Kamiya Yukiko

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 9 )   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms21093276

    Web of Science

    PubMed

  12. Crystallographic snapshots of the EF-hand protein MCFD2 complexed with the intracellular lectin ERGIC-53 involved in glycoprotein transport. Reviewed International journal

    Tadashi Satoh, Miho Nishio, Kousuke Suzuki, Maho Yagi-Utsumi, Yukiko Kamiya, Tsunehiro Mizushima, Koichi Kato

    Acta crystallographica. Section F, Structural biology communications   Vol. 76 ( Pt 5 ) page: 216 - 221   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The transmembrane intracellular lectin ER-Golgi intermediate compartment protein 53 (ERGIC-53) and the soluble EF-hand multiple coagulation factor deficiency protein 2 (MCFD2) form a complex that functions as a cargo receptor, trafficking various glycoproteins between the endoplasmic reticulum (ER) and the Golgi apparatus. It has been demonstrated that the carbohydrate-recognition domain (CRD) of ERGIC-53 (ERGIC-53CRD) interacts with N-linked glycans on cargo glycoproteins, whereas MCFD2 recognizes polypeptide segments of cargo glycoproteins. Crystal structures of ERGIC-53CRD complexed with MCFD2 and mannosyl oligosaccharides have revealed protein-protein and protein-sugar binding modes. In contrast, the polypeptide-recognition mechanism of MCFD2 remains largely unknown. Here, a 1.60 Å resolution crystal structure of the ERGIC-53CRD-MCFD2 complex is reported, along with three other crystal forms. Comparison of these structures with those previously reported reveal that MCFD2, but not ERGIC-53-CRD, exhibits significant conformational plasticity that may be relevant to its accommodation of various polypeptide ligands.

    DOI: 10.1107/S2053230X20005452

    Web of Science

    PubMed

  13. Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor. Reviewed International journal

    Hirokazu Yagi, Maho Yagi-Utsumi, Rena Honda, Yusaku Ohta, Taiki Saito, Miho Nishio, Satoshi Ninagawa, Kousuke Suzuki, Takahiro Anzai, Yukiko Kamiya, Kazuhiro Aoki, Mahito Nakanishi, Tadashi Satoh, Koichi Kato

    Nature communications   Vol. 11 ( 1 ) page: 1368 - 1368   2020.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    MCFD2 and ERGIC-53, which are the products of causative genes of combined factor V and factor VIII deficiency, form a cargo receptor complex responsible for intracellular transport of these coagulation factors in the early secretory pathway. In this study, using an NMR technique, we successfully identified an MCFD2-binding segment from factor VIII composed of a 10 amino acid sequence that enhances its secretion. This prompted us to examine possible effects of attaching this sequence to recombinant glycoproteins on their secretion. We found that the secretion level of recombinant erythropoietin was significantly increased simply by tagging it with the passport sequence. Our findings not only provide molecular basis for the intracellular trafficking of coagulation factors and their genetic deficiency but also offer a potentially useful tool for increasing the production yields of recombinant glycoproteins of biopharmaceutical interest.

    DOI: 10.1038/s41467-020-15192-1

    Web of Science

    PubMed

  14. The DNA Duplex as an Aqueous One-Dimensional Soft Crystal Scaffold for Photochemistry Reviewed International journal

    Asanuma Hiroyuki, Murayama Keiji, Kamiya Yukiko, Kashida Hiromu

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   Vol. 91 ( 12 ) page: 1739 - 1748   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/bcsj.20180278

    Web of Science

  15. Bifacial Nucleobases for Hexaplex Formation in Aqueous Solution Reviewed International journal

    Kashida Hiromu, Hattori Yuhei, Tazoe Kaho, Inoue Tadashi, Nishikawa Keiji, Ishii Kentaro, Uchiyama Susumu, Yamashita Hayato, Abe Masayuki, Kamiya Yukiko, Asanuma Hiroyuki

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Vol. 140 ( 27 ) page: 8456 - 8462   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.8b02807

    Web of Science

    PubMed

  16. Strand-invading linear probe combined with unmodified PNA Reviewed International journal

    Aasanuma, H.; Niwa, R.; Akahane, M.; Murayama, K.; Kashida, H.; Kamiya, Y.

    Bioorg. Med. Chem.   ( 24 ) page: 4129-4137   2016.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmc.2016.06.055

  17. Dynamics of Inter-DNA Chain Interaction of Photoresponsive DNA Reviewed International journal

    Nakasone, Y.; Ooi, H.; Kamiya, Y.; Asanuma, H.; Terazima, M.

    J. Am. Chem. Soc.   Vol. 29 ( 138 ) page: 9001-9004   2016.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.6b02525

  18. Terminus-free siRNA prepared by photo-crosslinking activated via slicing by Ago2 Reviewed International journal

    Yukiko Kamiya, Kazuki Iishiba, Tetsuya Doi, Kouki Tsuda, Hiromu Kashida, Hiroyuki Asanuma

    Biomaterials Science   Vol. 12 ( 3 ) page: 1534-1538   2015.12

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C5BM00231A

  19. Isotope effect on the circular dichroism spectrum of methyl α-D-glucopyranoside in aqueous solution Reviewed International journal

    Kanematsu, Y.; Kamiya, Y.; Matsuo, K.; Gekko, K.; Kato, K.; Tachikawa, M.

    Scientific Reports   ( 5 ) page: 17900   2015.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep17900

  20. Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway Reviewed International journal

    Ninagawa, S.; Okada, T.; Sumitomo, Y.; Horimoto, S.; Sugimoto, T.; Ishikawa, T.; Takeda, S.; Yamamoto, T.; Suzuki, T.; Kamiya, Y.; Kato, K.; Mori, K.

    J. Cell Biol.   ( 211 ) page: 775-784   2015.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  21. Redox-coupled structural changes of the catalytic a' domain of protein disulfide isomerase Reviewed International journal

    Inagaki Koya, Satoh Tadashi, Yagi-Utsumi Maho, Le Gulluche Anne-Charlotte, Anzai Takahiro, Uekusa Yoshinori, Kamiya Yukiko, Kato Koichi

    FEBS LETTERS   Vol. 589 ( 19 ) page: 2690-2694   2015.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.febslet.2015.07.041

    Web of Science

  22. Ultrasensitive Molecular Beacon Designed with Totally Serinol Nucleic Acid (SNA) for Monitoring mRNA in Cells. Reviewed International journal

    Murayama K, Kamiya Y, Kashida H, Asanuma H

    Chembiochem : a European journal of chemical biology   Vol. 16 ( 9 ) page: 1298-301   2015.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbic.201500167

    PubMed

  23. Molecular design of Cy3 derivative for highly sensitive in-stem molecular beacon and its application to the wash-free FISH Reviewed International journal

    Kashida Hiromu, Osawa Takuya, Morimoto Kazuhiro, Kamiya Yukiko, Asanuma Hiroyuki

    BIOORGANIC & MEDICINAL CHEMISTRY   Vol. 23 ( 8 ) page: 1758-1762   2015.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmc.2015.02.030

    Web of Science

  24. Highly sensitive and robust linear probe for detection of mRNA in cells Reviewed International journal

    Asanuma, H.; Akahane, M.; Niwa, R.; Kashida, H.; Kamiya, Y.

    Angew. Chem. Int. Ed.   Vol. 54   page: 4315-4319   2015.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  25. Synthetic gene involving azobenzene-tethered T7 promoter for the photocontrol of gene expression by visible light Reviewed International journal

    Kamiya, Y.; Takagi, T.; Ooi, H.; Ito, H.; Liang, X.G.; Asanuma, H.

    ACS Synth. Biol.   Vol. 4   page: 365-370   2015

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  26. Enhancement of Stability and Activity of siRNA by Terminal Substitution with Serinol Nucleic Acid (SNA) Reviewed International journal

    Kamiya Yukiko, Takai Junya, Ito Hiroshi, Murayama Keiji, Kashida Hiromu, Asanuma Hiroyuki

    CHEMBIOCHEM   Vol. 15 ( 17 ) page: 2549-2555   2014.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbic.201402369

    Web of Science

  27. Recent advances in glycoprotein production for structural biology:toward tailored design of glycoforms Invited Reviewed International journal

    Kamiya, Y.; Satoh T.; Kato, K.

    Current Opinion in Structural Biology   ( 26 ) page: 44-53   2014

     More details

    Authorship:Lead author   Language:English  

  28. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step Reviewed International journal

    Ninagawa, S.; Okada, T.; Sumitomo, Y.; Kamiya, Y.; Kato, K.; Horimoto, S.; Ishikawa, T.; Takeda, S.; Sakuma, T.; Yamamoto, T.; Mori, K.

    J. Cell Biol.   Vol. 206   page: 347-356   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  29. De Novo Design of Functional Oligonucleotides with Acyclic Scaffolds Reviewed International journal

    Asanuma, H.; Kashida, H.; Kamiya, Y.

    Chem. Rec.     page: -   2014

     More details

    Language:English  

    DOI: 10.1002/tcr.201402040

  30. Light-driven DNA nanomachine with a photoresponsive molecular engine Reviewed International journal

    Kamiya, Y.; Asanuma, H.

    Accounts of Chemical Research   Vol. 47   page: 1663-1672   2014

     More details

    Authorship:Lead author   Language:English  

  31. Selective labeling of mature RISC using siRNA carrying fluorophore-quencher pair Reviewed International journal

    Kamiya, Y.; Ito, A.; Ito, H.; Urushihara, M.; Takai, J.; Fujii, T.; Liang, X.G.; Kashida, H.; Asanuma, H.

    Chem. Sci.   ( 4 ) page: 4016-4021   2013

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  32. Application of metabolic 13C labeling in conjunction with high-field NMR spectroscopy for comparative conformational analysis of high mannose-type oligosaccharides Reviewed International journal

    Kamiya, Y.; Yanagi, K.; Kitajima, T.; Yamaguchi, T.; Chiba, Y.; Kato, K.

    Biomolecules   ( 3 ) page: 108-123   2013

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  33. Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant Reviewed International journal

    Fujimori, T.; Kamiya, Y.; Nagata, K.; Kato, K.; Hosokawa, N.

    FEBS J.   ( 280 ) page: 1563-1575   2013

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  34. Terminal Spin Labeling of a High-mannose-type Oligosaccharide for Quantitative NMR Analysis of Its Dynamic Conformation Reviewed International journal

    Yamaguchi, T.; Kamiya, Y.; Choo, Y.M.; Yamamoto, S.; Kato, K.

    Chem. Lett.   ( 42 ) page: 544-546   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  35. An archaeal homolog of proteasome assembly factor functions as a proteasome activator Reviewed International journal

    Kumoi, K.; Satoh, T.; Murata, K.; Hiromoto, T.; Mizushima, T.; Kamiya, Y.; Noda, M.; Uchiyama, S.; Yagi, H.; Kato, K.

    PLoS ONE   ( 8 ) page: e60294   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  36. The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein. Reviewed International journal

    Horimoto, S.; Ninagawa, S.; Okada, T,; Koba, H.; Sugimoto, T.; Kamiya, Y.; Kato, K.; Takeda, S.; and Mori, K.

    J. Biol. Chem.   ( 288 ) page: 31517-31527   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  37. Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases Reviewed International journal

    Araki,K.; Iemura, S.; Kamiya, Y.; Ron, D.; Kato, K.; Natsume, T.; and Nagata, K.

    J. Cell Biol.   ( 202 ) page: 861-874   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  38. NMR characterization of the interaction between the PUB domain of peptide:N-glycanase and ubiquitin-like domain of HR23 Reviewed International journal

    Y. Kamiya, Y. Uekusa, A. Sumiyoshi, H. Sasakawa, T. Hirao, T. Suzuki, and K. Kato

    FEBS Letter   Vol. 586   page: 1141-1146   2012

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  39. Molecular and structural basis for N-glycan-dependent determination of glycoprotein fates in cells Reviewed International journal

    Y. Kamiya, T. Satoh, and K. Kato

    Biochimica et Biophysica Acta - General Subjects   Vol. 1820   page: 1327-1337   2012

     More details

    Authorship:Lead author   Language:English  

  40. N-Glycosylation Profiles of Chicken Immunoglobulin Y Glycoproteins Expressed by Different Production Vehicles Reviewed International journal

    Sachiko Kondo, Hirokazu Yagi, Yukiko Kamiya, Akihiko Ito, Motoki Kuhara, Ayako Kudoh, Noriko Takahashi, Koichi Kato

    Journal of Glycomics and lipidmics     page: S5   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  41. Overexpression of a Homogeneous Oligosaccharide with 13C Labeling by Genetically Engineered Yeast Strain Reviewed International journal

    Y. Kamiya, S. Yamamoto, Y. Chiba, Y. Jigami, and K. Kato

    Journal of Biomolecular NMR   Vol. 50   page: 397-401   2011

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  42. Structural and Molecular Basis of Carbohydrate-Protein Interaction Systems as Potential Therapeutic Targets Reviewed International journal

    Y. Kamiya, M. Yagi-Utsumi, H. Yagi, and K. Kato

    Current Pharmaceutical Design   Vol. 17   page: 1672-1684   2011

     More details

    Authorship:Lead author   Language:English  

  43. The role of MRH domain-containing lectins in ERAD Reviewed International journal

    Hosokawa Nobuko, Kamiya Yukiko, Kato Koichi

    GLYCOBIOLOGY   Vol. 20 ( 6 ) page: 651-660   2010.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/glycob/cwq013

    Web of Science

  44. Structural Basis for the Cooperative Interplay between the Two Causative Gene Products of Combined Factor V and Factor VIII Deficiency Reviewed International journal

    M. Nishio, Y. Kamiya, T. Mizushima, S. Wakatsuki, H. Sasakawa, K. Yamamoto, S. Uchiyama, M. Noda, A.R. McKay, K. Fukui, H.P. Hauri, and K. Kato

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 107   page: 4034-4039   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  45. Redox-Dependent Domain Rearrangement of Protein Disulfide Isomerase Coupled with Exposure of its Substrate-Binding Hydrophobic Surface Reviewed International journal

    O. Serve*, Y. Kamiya*, A. Maeno*, M. Nakano*, C. Murakami, H. Sasakawa, Y. Yamaguchi, T. Harada, E. Kurimoto, M. Yagi-Utsumi, T. Iguchi, K. Inaba, J. Kikuchi, O. Asami, T. Kajino, T. Oka, M. Nakasako, and K. Kato(*These authors contributed equally to this work)

    Journal of Molecular Biology   Vol. 396   page: 361-374   2010

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  46. EDEM1 Accelerates the Trimming of α1,2-linked Mannose on the C Branch of N-glycans Reviewed International journal

    N. Hosokawa, .L. Tremblay, B. Sleno, Y. Kamiya, I. Wada, K. Nagata, K. Kato, and A. Herscovics

    Glycobiology   Vol. 20   page: 567-575   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  47. 糖鎖によるタンパク質社会の秩序維持 Reviewed International journal

    神谷由紀子、加藤晃一

    化学工業   Vol. 61   page: 23-31   2010

     More details

    Authorship:Lead author   Language:Japanese  

  48. MANNOSE 6-PHOSPHATE RECEPTOR HOMOLOGY DOMAIN-CONTAINING LECTINS IN MAMMALIAN ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION Reviewed International journal

    Hosokawa Nobuko, Kato Koichi, Kamiya Yukiko

    METHODS IN ENZYMOLOGY, VOL 480: GLYCOBIOLOGY   Vol. 480   page: 181-197   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0076-6879(10)80010-2

    Web of Science

  49. Sugar-binding activity of the MRH domain in the ER alpha-glucosidase II beta subunit is important for efficient glucose trimming Reviewed International journal

    Hu Dan, Kamiya Yukiko, Totani Kiichiro, Kamiya Daiki, Kawasaki Norihito, Yamaguchi Daisuke, Matsuo Ichiro, Matsumoto Naoki, Ito Yukishige, Kato Koichi, Yamamoto Kazuo

    GLYCOBIOLOGY   Vol. 19 ( 10 ) page: 1127-1135   2009.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/glycob/cwp104

    Web of Science

  50. Human OS-9, a Lectin Required for Glycoprotein ERAD, Recognizes Mannose-Trimmed N-glycans Reviewed International journal

    N. Hosokawa*, Y. Kamiya*, D. Kamiya, K. Kato, and K. Nagata (*Both authors contributed equally to this work)

    Journal of Biological Chemistry   Vol. 284   page: 17061-17068   2009

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  51. 糖鎖認識を介した糖タンパク質の細胞内運命の決定機構 Reviewed International journal

    神谷由紀子、加藤晃一

    生物物理   Vol. 49   page: 62-69   2009

     More details

    Authorship:Lead author   Language:Japanese  

  52. Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation Reviewed International journal

    Quan Erin M., Kamiya Yukiko, Kamiya Dailki, Denic Vladimir, Weibezahn Jimena, Kato Koichi, Weissman Jonathan S.

    MOLECULAR CELL   Vol. 32 ( 6 ) page: 870-877   2008.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molcel.2008.11.017

    Web of Science

  53. Deletion of 3 residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and factor VIII deficiency Reviewed International journal

    Nyfeler Beat, Kamiya Yukiko, Boehlen Francoise, Yamamoto Kazuo, Kato Koichi, de Moerloose Philippe, Hauri Hans-Peter, Neerman-Arbez Marguerite

    BLOOD   Vol. 111 ( 3 ) page: 1299-1301   2008.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2007-09-112854

    Web of Science

  54. 920 MHz Ultra-High Field NMR Approaches to Structural Glycobiology Reviewed International journal

    K. Kato, H. Sasakawa, Y. Kamiya, M. Utsumi, M. Nakano, N. Takahashi, and Y. Yamaguchi

    Biochimica et Biophysica Acta-General Subjects   Vol. 1780   page: 619-625   2008

     More details

    Language:English  

  55. Molecular Basis of Sugar Recognition by the Human L-type Lectins ERGIC-53, VIPL and VIP36 Reviewed International journal

    Y. Kamiya, D. Kamiya, K. Yamamoto, B. Nyfeler, H.P. Hauri, and K. Kato

    Journal of Biological Chemistry   Vol. 183   page: 1857-1861   2008

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  56. 細胞内レクチンによる糖タンパク質の輸送と品質管理の構造基盤 Reviewed International journal

    神谷由紀子、加藤晃一

    蛋白質 核酸 酵素   Vol. 53   page: 1662-1669   2008

     More details

    Language:Japanese  

  57. Structural views of glycoprotein-fate determination in cells Reviewed International journal

    Kato Koichi, Kamiya Yukiko

    GLYCOBIOLOGY   Vol. 17 ( 10 ) page: 1031-1044   2007.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/glycob/cwm046

    Web of Science

  58. Fbs1 Protects the Malfolded Glycoproteins from the Attack of Peptide:N-glycanase Reviewed International journal

    Y. Yamaguchi, T. Hirao, E. Sakata, Y. Kamiya, E. Kurimoto,Y. Yoshida, T. Suzuki, K. Tanaka, and K. Kato

    Biochemical and Biophysical Research Communications   Vol. 362   page: 712-716   2007

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  59. Sugar recognition by intracellular lectins that determine the fates of glycoproteins Reviewed International journal

    Kamiya Yukiko, Kato Koichi

    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY   Vol. 18 ( 102 ) page: 231-244   2006.7

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  60. Sugar-Binding Properties of VIP36, an Intracellular Animal Lectin Operating as a Cargo Receptor Reviewed International journal

    Y. Kamiya, Y. Yamaguchi, N. Takahashi, Y. Arata, K. Kasai, Y. Ihara, I. Matsuo, Y. Ito, K. Yamamoto, K. Kato

    Journal of Biological Chemistry   Vol. 280   page: 37178-82   2005

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  61. NMRを利用した糖鎖構造生物学 Reviewed

    神谷由紀子、山口芳樹、加藤晃一

    糖鎖科学の新展開-機能解明・次世代型材料・医薬品開発に向けて-(谷口直之、伊藤幸成編) エヌ・ティー・エス     page: 76-83   2005

     More details

    Authorship:Lead author   Language:Japanese  

▼display all

Books 9

  1. 光応答性DNAの搭載によるナノマシンとナノ構造体の光制御

    浅沼浩之, 神谷由紀子( Role: Joint author)

    化学同人  2021.10  ( ISBN:9784759814019

     More details

    Language:Japanese

  2. 医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略

    神谷由紀子( Role: Contributor)

    株式会社 情報機構  2019.10 

     More details

    Responsible for pages:33-42   Language:Japanese Book type:Scholarly book

  3. ナノマテリアルとしての光応答性DNA

    浅沼浩之, 神谷由紀子( Role: Joint author)

    エヌ・ティー・エス  2018.12  ( ISBN:9784860435356

     More details

    Responsible for pages:581-587   Language:Japanese Book type:Scholarly book

  4. 非環状骨格型人工核酸:aTNA, SNA

    神谷由紀子, 村山恵司, 樫田 啓, 浅沼浩之( Role: Joint author)

    シーエムシー出版  2016.2 

     More details

    Language:Japanese

  5. Conformational dynamics of oligosaccharides characterized by paramagnetism-assisted NMR spectroscopy in conjunction with molecular dynamics simulation

    Zhang, Y.; Yamaguchi, T.; Yagi-Utsumi, M.; Kamiya, Y.; Sakae, Y.; Okamoto, Y.; Kato, K.( Role: Joint author)

    Springer (Switzerland)  2014.11 

     More details

    Language:English

  6. 核酸医薬を目指した機能性siRNA

    神谷由紀子、浅沼浩之( Role: Joint author)

    -  2014 

     More details

    Language:Japanese

  7. ナノ環境に優しい光応答性DNAの設計

    神谷由紀子、浅沼浩之( Role: Joint author)

    コロナ社  2013 

     More details

    Language:Japanese

  8. Redox-Dependent Chaperoning, Following PDI Footsteps

    O. Serve, Y. Kamiya, and K. Kato( Role: Joint author)

    NOVA Science Publishers  2010 

     More details

    Language:English

  9. Sophisticated Modes of Sugar Recognition by Intracellular Lectins Involved in Quality Control of Glycoproteins

    Y. Kamiya, D. Kamiya, R. Urade, T. Suzuki, and K. Kato( Role: Joint author)

    NOVA Science Publishers  2009 

     More details

    Language:English

▼display all

MISC 3

  1. Design of photofunctional oligonucleotides by copolymerization of natural nucleobases with base surrogates prepared from acyclic scaffolds Invited Reviewed

    Hiroyuki Asanuma, Keiji Murayama, Yukiko Kamiya, Hiromu Kashida

    POLYMER JOURNAL   Vol. 49 ( 3 ) page: 279 - 289   2017.3

     More details

    Language:English   Publishing type:Book review, literature introduction, etc.   Publisher:NATURE PUBLISHING GROUP  

    Further development of DNA nanotechnology requires new functional oligonucleotides composed of nucleobases beyond the native four. In this review, we demonstrate new methodology for DNA and RNA functionalization using a base surrogate prepared from D-threoninol (2-amino-1,3-butanediol). Using this nucleobase surrogate, we can introduce functional molecules at any position of the sequence. Our methodology is conceptually similar to the copolymerization of multiple monomers: phosphoramidite monomers corresponding to the base surrogate and natural nucleotides are copolymerized on a solid support to prepare the functional oligonucleotides. Copolymerization allows for stable functional motifs, including wedges, interstrandwedges, dimers and clusters. By selecting suitable functional molecules and motifs, we can design photofunctional oligonucleotides, such as: (1) photoresponsive DNA that enables reversible formation and dissociation of the duplex by photoirradiation; (2) [2+ 2] photocycloaddition of stilbene derivatives; (3) orientation-dependent FRET (fluorescence (Forster) resonance energy transfer) systems; (4) sequence-specific fluorescent probe for the detection of DNA and RNA; and (5) functional siRNA for fluorescent labeling of mature RISC (RNA-induced silencing complex).

    DOI: 10.1038/pj.2016.120;

    Web of Science

  2. Design of photofunctional oligonucleotides by copolymerization of natural nucleobases with base surrogates prepared from acyclic scaffolds

    Hiroyuki Asanuma, Keiji Murayama, Yukiko Kamiya, Hiromu Kashida

    POLYMER JOURNAL   Vol. 49 ( 3 ) page: 279 - 289   2017.3

     More details

    Language:English   Publishing type:Book review, literature introduction, etc.   Publisher:NATURE PUBLISHING GROUP  

    Further development of DNA nanotechnology requires new functional oligonucleotides composed of nucleobases beyond the native four. In this review, we demonstrate new methodology for DNA and RNA functionalization using a base surrogate prepared from D-threoninol (2-amino-1,3-butanediol). Using this nucleobase surrogate, we can introduce functional molecules at any position of the sequence. Our methodology is conceptually similar to the copolymerization of multiple monomers: phosphoramidite monomers corresponding to the base surrogate and natural nucleotides are copolymerized on a solid support to prepare the functional oligonucleotides. Copolymerization allows for stable functional motifs, including wedges, interstrandwedges, dimers and clusters. By selecting suitable functional molecules and motifs, we can design photofunctional oligonucleotides, such as: (1) photoresponsive DNA that enables reversible formation and dissociation of the duplex by photoirradiation; (2) [2+ 2] photocycloaddition of stilbene derivatives; (3) orientation-dependent FRET (fluorescence (Forster) resonance energy transfer) systems; (4) sequence-specific fluorescent probe for the detection of DNA and RNA; and (5) functional siRNA for fluorescent labeling of mature RISC (RNA-induced silencing complex).

    DOI: 10.1038/pj.2016.120;

    Web of Science

  3. Pre-organized guide RNA in Cas9 complex is ready for selection of the target double-stranded DNA Invited Reviewed

    Kamiya, Y.; Asanuma, H.

    ChemBioChem   ( 211 ) page: 775-784   2015.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Presentations 98

  1. 光クロスリンク法を用いたDicer-PAZ/PlatformのdsRNAコンタクト構造の特定

    神谷 由紀子、鈴木 駿也、横田 徳子、 津田 弘貴、浅沼 浩之

    日本薬学会第142年会  2022.3.28 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  2. 非環状型人工核酸からなるエキソンスキップ型ASOの開発

    神谷由紀子、桑島涼太、浅沼浩之

    日本化学会 第102春季年会   2022.3.25 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  3. Development of siRNA and anti-miRNA oligonucleotide modified with SNA or L-aTNA Invited International conference

    Yukiko Kamiya, Fuminori Sato, Tomonari Mizuno, Hiroyuki Asanuma

    Pacifichem2021  2021.12 

     More details

    Event date: 2021.12

    Language:English   Presentation type:Oral presentation (invited, special)  

  4. FRET型pre-miRNAの開発とmiRNA成熟過程の可視化解析

    神谷由紀子, 神元 寛, 朱 紅宇, 浅沼浩之

    日本核酸医薬学会第6回年会  2021.6 

     More details

    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  5. 非環状型人工核酸を用いた核酸医薬を指向する機能性核酸の設計 Invited

    神谷由紀子

    第21回日本蛋白質科学会年会  2021.6 

     More details

    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  6. Helix of life:New study shows how 'our' RNA stably binds to artificial nucleic acids

    神谷由紀子

    第3回 ExCELLSシンポジウム  2020.12.21  自然科学研究機構生命創成探究センター

     More details

    Event date: 2020.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:オンライン  

  7. Pseudo complementary塩基対を用いたSNA型アンチセンス核酸の高活性化

    神谷由紀子, 佐藤史経, 村山恵司, 浅沼浩之

    第14回バイオ関連化学シンポジウム  2020.9.7 

     More details

    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  8. RNAを認識する非環状型人工核酸の結晶構造解析

    神谷由紀子, 佐藤匡史, 兒玉篤治, 鈴木達哉, 内山 進, 加藤晃一, 浅沼浩之

    第30回バイオ・高分子シンポジウム  2020.7.30 

     More details

    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  9. 非環状型人工核酸とRNAの結晶構造解析

    神谷由紀子, 佐藤匡史, 兒玉篤治, 鈴木達哉, 内山 進, 加藤晃一, 浅沼浩之

    日本化学会第100春季年会  

     More details

    Event date: 2020.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  10. 核酸医薬開発を目指した非環状型人工核酸の活用 Invited

    神谷由紀子

    核酸化学懇話会2020 北海道・東地区セミナー  

     More details

    Event date: 2020.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  11. SNA modification on siRNA and anti-miRNA oligonucleotide for improvement of their performance International conference

    Yukiko Kamiya, Jumpei Ariyoshi, Hiroshi Kamimoto, Yuka Donoshita, Junya Takai, Keiji Murayama, Hiroyuki Asanuma

    15th Annual Meeting Of The OTS 

     More details

    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

    Country:Germany  

  12. 光クロスリンク法によるDicerとRNAの相互作用部位の検出

    神谷由紀子, 横田徳子, 津田弘貴, 浅沼浩之

    第13回バイオ関連化学シンポジウム 

     More details

    Event date: 2019.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  13. Design of siRNA and anti-miRNA oligonucleotude by using acyclic nucleic acid International conference

    Yukiko Kamiya, Jumpei Ariyoshi, Hiroshi Kamimoto, Yuka Donoshita, Keiji Murayama, Hiroyuki Asanuma

    CISNAC2019 

     More details

    Event date: 2019.7

    Language:English   Presentation type:Poster presentation  

    Venue:Port Island Campus, Konan Unversity   Country:Japan  

  14. 色素対導入型siRNAを用いたRISCの可視化解析

    神谷由紀子、佐武真有、伊藤杏奈、浅沼浩之

    日本核酸医薬学会第5回年会 

     More details

    Event date: 2019.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:ホテル阪急エキスポパーク   Country:Japan  

  15. 遺伝子発現制御を目指した可視光応答性10-23DNAzymeの開発

    神谷由紀子, 有村 優, 大威英晃, 加藤憲司郎, 梁 興国, 浅沼浩之

    日本化学会第99春季年会 

     More details

    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:甲南大学   Country:Japan  

  16. 非環状型人工核酸を活用した次世代型核酸医薬の開発

    神谷由紀子

    名古屋大学 予防早期医療創成センター 第8回ワークショップ 

     More details

    Event date: 2019.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋大学   Country:Japan  

  17. 人工核酸を活用した遺伝子発現を制御する機能性核酸の開発 Invited

    神谷由紀子

    サントリー生有研シンポジウム 分子で解き明かす生命現象 ~生体分子を「視る」「捕まえる」「操作する」~ 

     More details

    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:サントリーワールドリサーチセンター   Country:Japan  

  18. Development of visible light-responsive 10-23 DNAzyme International conference

    Yukiko Kamiya, Yu Arimura, Hideaki Ooi, Kenjiro Kato, Xingguo Liang, Hiroyuki Asanuma

    The 45th International Symposium on Nucleic Acid Chemistry (ISNAC2018) 

     More details

    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto University   Country:Japan  

  19. 非環状骨格型人工核酸を活用したRISC形成を制御するsiRNAの設計

    神谷由紀子, 竹山雄貴, 高井順矢, 村山恵司, 浅沼浩之

    第12回バイオ関連化学シンポジウム 

     More details

    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪大学 吹田キャンパス   Country:Japan  

  20. 色素導入pre-miRNAの開発とmiRNA成熟過程の解析

    神谷由紀子, 竹山雄貴, 浅沼浩之

    第28回バイオ・高分子シンポジウム 

     More details

    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東工大 大岡山キャンパス   Country:Japan  

  21. 非環状型人工核酸を骨格とするanti-miRNA oligonucleotideの開発

    神谷由紀子、堂下裕香、神元 寛、高井順矢、有吉純平、村山恵司、浅沼浩之

    日本核酸医薬学会第4回年会 

     More details

    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:九州大学医学部百年講堂   Country:Japan  

  22. RNA干渉を理解し制御する人工核酸の開発 Invited

    神谷由紀子

    第67回高分子学会年次大会 

     More details

    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋国際会議場   Country:Japan  

  23. RNAiに作用する機能性核酸の高性能化に向けた非環状型人工核酸SNAの活用

    神谷由紀子、堂下裕香、神元 寛、高井順矢、村山恵司、有吉純平、浅沼浩之

    日本化学会第98春季年会 

     More details

    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日本大学理工学部   Country:Japan  

  24. 非環状型人工核酸を活用した次世代型核酸医薬の開発

    神谷由紀子、有吉純平、村山恵司、浅沼浩之

    名古屋大学 予防早期医療創成センター 第7回ワークショップ 

     More details

    Event date: 2018.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋大学   Country:Japan  

  25. Development of anti-miR oligonucleotide by using serinol nucleic acid and 2,6-diaminopurines International conference

    Yukiko Kamiya, Yuka Donoshita, Hiroshi Kamimoto, Keiji Murayama, Jumpei Ariyoshi, Hiroyuki

     More details

    Event date: 2017.11

    Language:English   Presentation type:Poster presentation  

    Venue:Tokyo University of Science   Country:Japan  

  26. miRNAの成熟過程を解析する色素導入型pre-miRNAの開発

    神谷由紀子、神元寛、浅沼浩之

    第11回バイオ関連化学シンポジウム 

     More details

    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学 弥生キャンパス   Country:Japan  

  27. 色素導入pre-miRNAの開発とmiRNA成熟過程の解析

    神谷由紀子、神元寛、浅沼浩之

    第27回バイオ・高分子シンポジウム 

     More details

    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東工大 大岡山キャンパス   Country:Japan  

  28. 非環状骨格型人工核酸を用いたanti-miR oligonucleotideの開発

    神谷由紀子、堂下裕香、村山恵司、浅沼浩之

    第10回バイオ関連化学シンポジウム 

     More details

    Event date: 2016.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  29. 非環状骨格型人工核酸を用いたmiRNAを標的とするアンチセンス核酸の開発

    神谷由紀子、堂下裕香、村山恵司、浅沼浩之

    第26回バイオ・高分子シンポジウム 

     More details

    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  30. 人工核酸によるRNA干渉機構の理解と制御 International conference

    神谷由紀子

    分子研シンポジウム2016  

     More details

    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:岡崎コンファレンスセンター   Country:Japan  

  31. 人工核酸を用いたRNA干渉機構の理解と制御法の開発

    神谷由紀子

    第160回名古屋市立大学薬学談話会 

     More details

    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋市立大学   Country:Japan  

  32. Ago2によるスライシングを介して活性化する架橋型siRNAの開発

    神谷由紀子, 飯柴一輝, 土居哲也, 樫田 啓, 浅沼浩之

    日本化学会第96春季年会 

     More details

    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:同志社大学   Country:Japan  

  33. Fluorescent monitoring of siRNA by modification with dye pairs in cell International conference

    Y. Kamiya, A. Ito, and H. Asanuma

    Pacifichem2015  

     More details

    Event date: 2015.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  34. Fluorescent monitoring of intracellular trafficking of siRNA International conference

    Yukiko Kamiya

    9th International Symposium on Nanomedicine  

     More details

    Event date: 2015.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  35. 色素対導入型siRNAによる細胞内イメージング解析

    神谷由紀子、伊藤杏奈、浅沼浩之

    BMB2015(第38回日本分子生物学会 第88回日本生化学会大会 合同大会) 

     More details

    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド   Country:Japan  

  36. Development of photoresponsive microcapsule made by DNA International conference

    Y. Kamiya, Y. Yamada, T. Muro, K. Matsuura, H. Asanuma

    International Symposium on EcoTopia Science (ISETS'15) 

     More details

    Event date: 2015.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  37. 糖骨格を持たない人工核酸を用いたRNAi機構の理解と高性能siRNAの開発

    神谷由紀子

    第13回 糖鎖科学コンソーシアムシンポジウム -糖鎖研究と多領域との統合- 

     More details

    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:ウインク愛知   Country:Japan  

  38. Fluorescent imaging of intracellular trafficking of siRNA International conference

    Yukiko Kamiya, Anna Ito, Hiroyuki Asanuma

    The 42nd International Symposium on Nucleic Acid Chemistry (ISNAC2015) 

     More details

    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  39. 酵素耐性能を持つ両末端架橋型siRNAの開発と活性化機構の解明

    神谷由紀子、飯柴一輝、土居哲也、樫田 啓、浅沼浩之

    第64回高分子討論会 

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東北大学 川内キャンパス   Country:Japan  

  40. siRNAの活性化機構に着目した細胞内イメージング解析

    神谷由紀子、伊藤杏奈、樫田 啓、浅沼浩之

    第9回バイオ関連化学シンポジウム  

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本大学 黒髪南地区キャンパス   Country:Japan  

  41. 非環状骨格を介した光応答性分子の導入による高機能核酸材料の開発

    神谷由紀子、浅沼浩之

    平成27年度生理学研究所研究会「膜システムの機能的・構造的統合」 

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:生理研研究所   Country:Japan  

  42. 両末端架橋型siRNAの開発と活性化機構の解析

    神谷由紀子、飯柴一輝、土居哲也、樫田 啓、浅沼浩之

    第25回バイオ・高分子シンポジウム 

     More details

    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東工大 大岡山キャンパス   Country:Japan  

  43. 光応答性DNAデバイスを用いた遺伝子発現を制御する人工システムの開発

    神谷由紀子

    国際高等研究所 研究プロジェクト「分子基盤に基づく生体機能への揺らぎとダイナミックネットワークの解明」2014年度第1回研究会 

     More details

    Event date: 2014.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:国際高等研究所, 京都   Country:Japan  

  44. Photoregulation of gene expression with functional oligonucleotide involving azobenzene derivatives International conference

    Yukiko Kamiya

    7th Korea-Japan Seminars on Biomolecular Sciences:Experiments and Simulations 

     More details

    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Korea, Republic of  

  45. Photo-triggered collapse of 3D microsphere by photo-driven DNA nanodevice International conference

    Yukiko Kamiya,Yoshinobu Yamada, Takahiro Muro, Xingguo Liang, Kazunori Matsuura, and Hiroyuki Aasanuma

    The 41st International Symposium on Nucleic Acid Chemistry  

     More details

    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  46. Light-triggered signal conversion of DNA to RNA International conference

    Yukiko Kamiya, Toshiki Takagi, Hiroshi Ito, Xingguo Liang and Hiroyuki Asanuma

    20th International Conference on DNA computing and Molecular Programming (DNA20) 

     More details

    Event date: 2014.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  47. 色素対導入型siRNAの開発とRISCの細胞内可視化解析

    神谷由紀子、伊藤杏奈、高井順矢、樫田 啓、浅沼浩之

    第8回バイオ関連化学シンポジウム 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山大 津島キャンパス   Country:Japan  

  48. 非環状骨格を持つ人工核酸の導入によるsiRNAの高機能化

    神谷 由紀子、伊藤 杏奈、高井 順矢、伊藤 浩、村山 恵司、樫田 啓、浅沼 浩之

    アンチセンス・遺伝子・デリバリーシンポジウム2014 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京医科歯科大 M&Dタワー   Country:Japan  

  49. Intracellular Monitoring of siRNA by Conjugation of Fluorescent Probe International conference

    Yukiko Kamiya, Anna Ito, Hiroshi Ito, Masaaki Urushihara, Junya Takai, Taiga Fujii, Xingguo Liang, Hiromu Kashida, and Hiroyuki Asanuma

    XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids 

     More details

    Event date: 2014.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Poland  

  50. 人工核酸SNAの導入によるsiRNAのRNAi活性と酵素耐性の向上

    神谷由紀子、高井順矢、村山恵司、伊藤 浩、樫田 啓、浅沼浩之

    第24回バイオ・高分子シンポジウム 

     More details

    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東工大 大岡山キャンパス   Country:Japan  

  51. 非環状骨格を導入したsiRNAによるRNAi活性の向上と酵素耐性の獲得 International conference

    神谷由紀子、高井順矢, 伊藤杏奈、村山恵司、伊藤浩, 樫田啓、浅沼浩之

    日本化学会第94春季年会(2014) 

     More details

    Event date: 2014.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日本化学会第94春季年会(2014)   Country:Japan  

  52. Regulation of gene expression by visible light irradiation with T7 promoter involving azobenzene derivatives International conference

    Yukiko Kamiya, Toshiki Takagi, Hiroshi Ito, Xingguo Liang, Hiroyuki Asanuma

    The 40th International Symposium on NucleicAcids Chemistry 

     More details

    Event date: 2013.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  53. RISCを選択的に可視化する色素導入型siRNAの開発と細胞内イメージング解析

    神谷由紀子、伊藤 杏奈、高井 順矢、漆原 雅朗、伊藤 浩、藤井 大雅、梁 興国、樫田 啓、浅沼 浩之

    第23 回バイオ・高分子シンポジウム 

     More details

    Event date: 2013.7 - 2013.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京工業大学大岡山キャンパス   Country:Japan  

  54. mature RISCを選択的に可視化する修飾siRNAの開発

    神谷 由紀子, 伊藤 杏奈, 高井 順矢, 樫田 啓, 浅沼 浩之

    第14回 日本RNA学会年会 

     More details

    Event date: 2013.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:ひめぎんホール(愛媛)   Country:Japan  

  55. Development of Modified siRNA for Improvement of RNAi Activity and Monitoring in Cells

    Yukiko Kamiya, Junya Takai, Masaaki Urushihara, Hiroshi Ito, Xingguo Liang, Anna Ito, Kenji Yoshida, Taiga Fujii, Hiromu Kashida, Hiroyuki Asanuma

     More details

    Event date: 2013.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  56. アンチセンス鎖と結合したmature RISCの選択的な可視化

    神谷由紀子、伊藤杏奈、高井順矢、漆原雅朗、伊藤 浩、藤井大雅、梁 興国、樫田 啓、浅沼浩之

    第77回日本生化学会中部支部例会 

     More details

    Event date: 2013.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋大学   Country:Japan  

  57. 色素対型siRNAを用いたRISCの細胞内可視化解析

    神谷由紀子、伊藤杏奈、高井順矢、漆原雅朗、伊藤浩、藤井大雅、梁興国、樫田啓、浅沼浩之

    日本薬学会 第133年会 

     More details

    Event date: 2013.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  58. Design and development of the functionalized siRNA International conference

    Yukiko Kamiya, Junya Takai, Masaaki Urushihara, Hiroshi Ito, Xingguo Liang, Anna Ito, Kenji Yoshida, Taiga Fujii, Hiromu Kashida, and Hiroyuki Asanuma

    The 39th International Symposium on Nucleic Acids Chemistry 

     More details

    Event date: 2012.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  59. Monitoring of RISC maturation by using siRNA labeled with fluorophore and quencher pair

     More details

    Event date: 2012.9

    Language:Japanese   Presentation type:Poster presentation  

  60. 小胞体関連分解に関わる脱糖鎖酵素はPUBドメインを介してユビキチンおよびユビキチン様ドメインと結合する

    神谷由紀子、住吉 晃、植草義徳、鈴木 匡、加藤晃一

    日本薬学会第132年会 

     More details

    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  61. Development of metabolic isotope-labeling techniques for NMR spectroscopic analyses of high-mannose-type oligosaccharides International conference

    Yukiko Kamiya, Sayoko Yamamoto, Yasunori Chiba, Yoshifumi Jigami, and Koichi Kato

    ISNMR 2011 

     More details

    Event date: 2011.11

    Language:English   Presentation type:Poster presentation  

  62. Molecular basis of glycoprotein-fate determination through interactions with intracellular lectins

    Yukiko Kamiya

    Global COE Mini-Symposium: Toward Systems Glycobiology-Biosynthesis and catabolism of glycoproteins 

     More details

    Event date: 2011.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  63. 遺伝子改変酵母を用いて安定同位体標識を施した高マンノース型糖鎖の超高磁場NMR解析

    神谷由紀子、山本さよこ、千葉靖典、喜多島敏彦、地神芳文、加藤晃一

    糖鎖科学名古屋拠点 第9回若手の力フォーラム 

     More details

    Event date: 2011.10

    Language:Japanese   Presentation type:Poster presentation  

  64. Development of metabolic 13C-labeling techniques for NMR analyses of high-mannose-type oligosaccharides using genetically engineered yeast strains International conference

    Yukiko Kamiya, Sayoko Yamamoto, Yasunori Chiba, Yoshifumi Jigami, and Koichi Kato

    The 71st Okazaki Conferenc-New Perspectives on Molecular Science of Glycoconjugates 

     More details

    Event date: 2011.10

    Language:English   Presentation type:Poster presentation  

  65. 糖タンパク質の細胞内運命決定機構の構造基盤

    神谷由紀子、住吉 晃、植草義徳、鈴木 匡、加藤晃一

    生化学若い研究者の会 第3回名古屋支部セミナー 

     More details

    Event date: 2011.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  66. 安定同位体標識と超高磁場NMR計測を用いた高マンノース型糖鎖の立体構造解析

    神谷由紀子、千葉靖典、喜多島敏彦、地神芳文、加藤晃一

    日本薬学会第131年会 

     More details

    Event date: 2011.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  67. Development of metabolic 13C-labeled techniques for NMR spectroscopic analyses of high-mannose-type oligosaccharides International conference

    Yukiko Kamiya, Yasunori Chiba, Yoshifumi Jigami, and Koichi Kato

    The 2010 International Chemical Congress of Pacific Basin Societies 

     More details

    Event date: 2010.12

    Language:English   Presentation type:Oral presentation (general)  

  68. Molecular basis of the glycoprotein-fate determination governed by the intracellular lectins International conference

    Yukiko Kamiya, Miho Nishio, and Koichi Kato

    The 2nd ACGG conference 

     More details

    Event date: 2010.10

    Language:English   Presentation type:Poster presentation  

  69. 糖タンパク質の品質管理を担う超分子複合体の作動メカニズムの構造基盤の解明

    神谷由紀子、西尾美穂、加藤晃一

    糖鎖科学名古屋拠点 第8回若手の力フォーラム 

     More details

    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  70. Development of metabolic 13C-labeling techniques for NMR structural analyses of high-mannose-type oligosaccharide International conference

    Yukiko Kamiya, Yasunori Chiba, Yoshifumi Jigami, and Koichi Kato

    The 25th International Cabohydrate Symposium 

     More details

    Event date: 2010.8

    Language:English   Presentation type:Poster presentation  

  71. 糖タンパク質の小胞体-ゴルジ体間の輸送を司る積荷輸送体の構造解析

    神谷由紀子、西尾美穂、水島恒裕、若槻壮市、山本一夫、内山 進、野田勝紀、Hans-Peter Hauri、加藤晃一

    日本薬学会第130年会 

     More details

    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  72. Structural basis of the molecular recognition by ERGIC-53 involved in the glycoprotein traffic in the cell International conference

    Yukiko Kamiya, Miho Nishio, Tsunehiro Mizushima, Kazuo Yamamoto, Susumu Uchiyama, Katsunori Noda, Hans-Peter Hauri, and Koichi Kato

    20th International Symposium on Glycoconjugates 

     More details

    Event date: 2009.11 - 2009.12

    Language:English   Presentation type:Oral presentation (general)  

  73. Molecular Basis of Fate-Determination of Glycoproteins Governed by the Sugar-Recognizing Proteins in Cells International conference

    Y. Kamiya, D. Kamiya, M. Nishio, and K. Kato

    Korea-Japan Seminars on Biomolecular Sciences-Experiments and Simulations 

     More details

    Event date: 2009.2 - 2009.3

    Language:English   Presentation type:Oral presentation (invited, special)  

  74. 超高磁場NMRによるタンパク質・複合糖質の動的高次構造解析

    加藤晃一、山口拓実、神谷由紀子

    新学術研究領域 第1回公開シンポジウム 

     More details

    Event date: 2009.1

    Language:Japanese   Presentation type:Oral presentation (general)  

  75. Molecular mechanisms underlying the glycoprotein-fate determination by the intracellular lectins

     More details

    Event date: 2008.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  76. Molecular and Structural Basis of the Mechanisms Underlying the Glycoprotein-Fate Determination by the Intracellular Lectins International conference

    Y. Kamiya, D. Kamiya, M. Nishio, and K. Kato

    The 23rd international lectin meeting 

     More details

    Event date: 2008.7

    Language:English   Presentation type:Oral presentation (general)  

  77. Sugar-binding Properties of VIP36, an Intracellular Animal Lectin Operating as a Cargo Receptor International conference

    Y. Kamiya, H. Tsukakoshi, Y. Yamaguchi, N. Takahashi, Y. Arata, K. Kasai, Y. Ihara, I. Matsuo, Y. Ito, K. Yamamoto, and K. Kato

    18th International Symposium on Glycoconjugates 

     More details

    Event date: 2005.9

    Language:English   Presentation type:Oral presentation (general)  

  78. Structural Basis of Sugar Recognition by the Cargo Receptor VIP36 International conference

    Y. Kamiya, Y. Yamaguchi, I. Matsuo, Y. Ito, M. Toyomoto, N. Matsumoto, K. Yamamoto, and K. Kato

    USA/Japan Glyco 2004 

     More details

    Event date: 2004.11

    Language:English   Presentation type:Poster presentation  

  79. Interaction between the Transport Lectin VIP36 and N-glycans as Studied by NMR Spectroscopy International conference

    Y. Kamiya, Y. Yamaguchi, I. Matsuo, Y. Ito, M. Toyomoto, N. Matsumoto, K. Yamamoto, and K. Kato

    The 21st International Lectin Meeting 

     More details

    Event date: 2004.5

    Language:English   Presentation type:Poster presentation  

  80. 色素導入pre-miRNAの開発とmiRNA成熟過程の解析 International conference

    神谷由紀子, 神元寛, 浅沼浩之

    第27回バイオ・高分子シンポジウム  2017.6.27 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東工大 大岡山キャンパス  

  81. 色素対導入型siRNAを用いたRISCの可視化解析 International conference

    神谷由紀子, 佐武真有, 伊藤杏奈, 浅沼浩之

    日本核酸医薬学会第5回年会  2019.7.10 

     More details

    Language:Japanese   Presentation type:Poster presentation  

    Venue:ホテル阪急エキスポパーク  

  82. 核酸医薬開発を目指した非環状型人工核酸の活用 Invited International conference

    神谷由紀子

    核酸化学懇話会2020 北海道・東地区セミナー  2020.1.9 

     More details

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  83. 光クロスリンク法によるDicerとRNAの相互作用部位の検出 International conference

    神谷由紀子, 横田徳子, 津田弘貴, 浅沼浩之

    第13回バイオ関連化学シンポジウム  2019.9.4 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  84. 人工核酸を活用した遺伝子発現を制御する機能性核酸の開発 Invited International conference

    神谷由紀子

    サントリー生有研シンポジウム 分子で解き明かす生命現象 ~生体分子を「視る」「捕まえる」「操作する」~  2018.12.4 

     More details

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:サントリーワールドリサーチセンター  

  85. SNA modification on siRNA and anti-miRNA oligonucleotide for improvement of their performance

    Yukiko Kamiya, Jumpei Ariyoshi, Hiroshi Kamimoto, Yuka Donoshita, Junya Takai, Keiji Murayama, Hiroyuki Asanuma

    15th Annual Meeting Of The OTS  2019.10.13 

     More details

    Language:English   Presentation type:Poster presentation  

  86. RNA干渉を理解し制御する人工核酸の開発 Invited International conference

    神谷由紀子

    第67回高分子学会年次大会  2018.5.23 

     More details

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋国際会議場  

  87. RNAiに作用する機能性核酸の高性能化に向けた非環状型人工核酸SNAの活用 International conference

    神谷由紀子, 堂下裕香, 神元 寛, 高井順矢, 村山恵司, 有吉純平, 浅沼浩之

    日本化学会第98春季年会  2018.3.20 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日本大学理工学部  

  88. miRNAの成熟過程を解析する色素導入型pre-miRNAの開発 International conference

    神谷由紀子, 神元寛, 浅沼浩之

    第11回バイオ関連化学シンポジウム  2017.9.7 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学 弥生キャンパス  

  89. Development of visible light-responsive 10-23 DNAzyme

    Yukiko Kamiya, Yu Arimura, Hideaki Ooi, Kenjiro Kato, Xingguo Liang, Hiroyuki Asanuma

    The 45th International Symposium on Nucleic Acid Chemistry (ISNAC2018)  2018.11.7 

     More details

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto University  

  90. Development of anti-miR oligonucleotide by using serinol nucleic acid and 2,6-diaminopurines

    Yukiko Kamiya, Yuka Donoshita, Hiroshi Kamimoto, Keiji Murayama, Jumpei Ariyoshi, Hiroyuki

    2017.11.14 

     More details

    Language:English   Presentation type:Poster presentation  

    Venue:Tokyo University of Science  

  91. Design of siRNA and anti-miRNA oligonucleotude by using acyclic nucleic acid

    Yukiko Kamiya, Jumpei Ariyoshi, Hiroshi Kamimoto, Yuka Donoshita, Keiji Murayama, Hiroyuki Asanuma

    CISNAC2019  2019.7.22 

     More details

    Language:English   Presentation type:Poster presentation  

    Venue:Port Island Campus, Konan Unversity  

  92. 色素導入pre-miRNAの開発とmiRNA成熟過程の解析 International conference

    神谷由紀子, 竹山雄貴, 浅沼浩之

    第28回バイオ・高分子シンポジウム  2018.7.26 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東工大 大岡山キャンパス  

  93. 非環状骨格型人工核酸を活用したRISC形成を制御するsiRNAの設計 International conference

    神谷由紀子, 竹山雄貴, 高井順矢, 村山恵司, 浅沼浩之

    第12回バイオ関連化学シンポジウム  2018.9.9 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪大学 吹田キャンパス  

  94. 非環状型人工核酸を骨格とするanti-miRNA oligonucleotideの開発 International conference

    神谷由紀子, 堂下裕香, 神元 寛, 高井順矢, 有吉純平, 村山恵司, 浅沼浩之

    日本核酸医薬学会第4回年会  2018.7.9 

     More details

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:九州大学医学部百年講堂  

  95. 非環状型人工核酸を活用した次世代型核酸医薬の開発 International conference

    神谷由紀子, 有吉純平, 村山恵司, 浅沼浩之

    名古屋大学 予防早期医療創成センター 第7回ワークショップ  2018.1.23 

     More details

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋大学  

  96. 非環状型人工核酸を活用した次世代型核酸医薬の開発 International conference

    神谷由紀子

    名古屋大学 予防早期医療創成センター 第8回ワークショップ  2019.1.29 

     More details

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋大学  

  97. 非環状型人工核酸とRNAの結晶構造解析 International conference

    神谷由紀子, 佐藤匡史, 兒玉篤治, 鈴木達哉, 内山 進, 加藤晃一, 浅沼浩之

    日本化学会第100春季年会  2020.3.22 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

  98. 遺伝子発現制御を目指した可視光応答性10-23DNAzymeの開発 International conference

    神谷由紀子, 有村 優, 大威英晃, 加藤憲司郎, 梁 興国, 浅沼浩之

    日本化学会第99春季年会  2019.3.16 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:甲南大学  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 7

  1. 構造情報に基づいた抗 RISC 核酸の設計基盤の開発

    2021.4

    公益財団法人野口研究所  2020年度野口遵研究助成金 

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2200000

  2. 非環状型人工核酸が形成するユニークな三重鎖構造に基づくRNA機能制御法の開発

    2021.4

    公益財団法人稲盛財団  2021年度稲盛研究助成 

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000

  3. 核酸医薬への応用を目指した非環状型人工核酸の開発

    Grant number:19am0401007  2019.9 - 2024.3

    先端的バイオ創薬等基盤技術開発事業 

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

  4. Dicerによる基質RNA認識選別機構の解明

    2019

    公益財団法人アステラス病態代謝研究会  2019年度アステラス病態代謝研究会 研究助成金 

      More details

    Authorship:Principal investigator 

    Grant amount:\2000000

  5. 完全人工核酸による抗miRNA活性を示す革新的アンチセンス核酸の開発

    2018 - 2020

    公益財団法人内藤記念科学振興財団  2018年度内藤記念女性研究者研究助成金 

      More details

    Authorship:Principal investigator 

    Grant amount:\6000000

  6. リボース骨格を持たない非環状型の核酸で狙うマイクロ RNA 制御法の開発

    2018

    公益財団法人持田記念医学薬学振興財団  平成30年度持田記念研究助成金 

      More details

    Authorship:Principal investigator 

    Grant amount:\3000000

  7. 細胞内動態を追跡するプローブ型siRNAの開発と蛍光イメージング解析による活性化制御機構の解明

    2015

    公益財団法人内藤記念科学振興財団  第46回内藤記念科学奨励金研究助成 

      More details

    Authorship:Principal investigator 

    Grant amount:\3000000

▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. RNAiを標的とする核酸医薬の作用機序解明に向けたイメージング解析

    Grant number:20K05745  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    神谷由紀子

      More details

    Authorship:Principal investigator  Grant type:Competitive

  2. siRNA可視化プローブによる細胞内イメージング解析

    Grant number:16K17932  2016.4 - 2019.3

    日本学術振興会  科学研究費助成事業  若手研究(B)

      More details

    Grant type:Competitive

  3. 人工核酸により発動する細胞様機能の構築

    Grant number:16H00762  2016.4 - 2018.3

    科学研究費助成事業  新学術領域研究(研究領域提案型)

    神谷 由紀子

      More details

    Authorship:Principal investigator 

    Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )

    生体高分子は、可逆的な分子修飾、集合・離散、プロセシングといった分子状態の変容によって、機能のOn/Offをスイッチングする仕組みを有している。したがって、分子間相互作用が、細胞機能へと変換される仕組みを理解し活用する手法の一つとして、生命作動システムの概念を人工的な分子で再構築すること、また、人工的な分子でシステムを単純化することがあげられる。本研究では、人工核酸を活用したシステムを開発し、生命システムにおける分子の相互作用、結合・解離などをヒントに人工分子の創出を行った。主な成果を以下に述べる。
    ①リポソームによる人工系の構築は、細胞様モデルや細胞内小胞モデルとして広く研究されている。本研究では、細胞や小胞の膜間の相互作用を人工核酸を用いて模倣するシステムの確立を試みた。
    ②細胞内での物質輸送は、クラスリンなどのタンパク質を裏打ち骨格とする小胞によって担われており、pHなどの外部環境の変化に応じて、小胞内の物質の荷下ろしが行われている。このことを 光応答性DNAを用いた物質輸送システムに応用した。具体的には、三種類の光応答性DNAによって形成するthree way junction構造(TWJ)を、TWJの末端部位(粘着末端)の間の相補的な二重鎖形成によって集積させることで、DNAからなるマイクロカプセルを構築した。粘着末端部位に光応答性分子を導入しておくことで、光刺激に応じて内包した物質を放出する仕組みを設計した。実際に、特定の波長の光刺激によって、このマイクロカプセルが崩壊し、それと同時に内包した物質を放出させることに成功した。
    ③人工核酸を用いた細胞内遺伝子発現の人工制御システムの開発、光応答性DNAの二重鎖形成と解離のダイナミクスに関する共同研究を推進した。
    29年度が最終年度であるため、記入しない。
    29年度が最終年度であるため、記入しない。

  4. 光応答性DNAによるK+チャネルKcsAの集合・離散構造の制御と協同的機能の解明

    Grant number:16K15178  2016.4 - 2018.3

    日本学術振興会  科学研究費助成事業  萌芽研究

      More details

    Grant type:Competitive

  5. DNAを相互作用素子として細胞様運動する人工システムの構築

    Grant number:26102518  2014.4 - 2016.3

    科学研究費補助金  新学術領域研究

    神谷由紀子

      More details

    Authorship:Principal investigator 

  6. 蛍光挿入型siRNAアナログを用いたRNA干渉の作動機構の解明

    Grant number:24750173  2012.4 - 2014.3

    科学研究費補助金  若手研究(B)

      More details

    Authorship:Principal investigator 

  7. 糖鎖認識を介したタンパク質社会の秩序維持機構の構造基盤の解明

    Grant number:22020039  2010.4 - 2012.3

    科学研究費補助金  特定領域研究

      More details

    Authorship:Principal investigator 

  8. 細胞内レクチンとCa結合タンパク質と連携による生体機能発現の分子基盤の探求

    Grant number:21870052  2009.4 - 2010.3

    科学研究費補助金  研究活動スタート支援

      More details

    Authorship:Principal investigator 

  9. ポスト小胞体品質管理における細胞内レクチンの分子認識と超分子形成の構造基盤の解明

    Grant number:21370050  2009.4 - 2012.3

    科学研究費補助金  基盤研究(B)

    加藤晃一

      More details

    Authorship:Coinvestigator(s) 

▼display all

 

Teaching Experience (On-campus) 32

  1. Biochemistry 1 with Exercises

    2020

  2. Biochemistry 1

    2020

  3. Biochemistry

    2020

  4. 分子生命化学セミナー 2D

    2020

  5. 分子生命化学セミナー 2C

    2020

  6. 分子生命化学セミナー 2B

    2020

  7. 分子生命化学セミナー 2A

    2020

  8. 分子生命化学特別実験及び演習4

    2020

  9. 分子生命化学特別実験及び演習3

    2020

  10. 分子生命化学特別実験及び演習2

    2020

  11. 分子生命化学特別実験及び演習1

    2020

  12. 分子生命化学セミナー 1D

    2020

  13. 分子生命化学セミナー 1C

    2020

  14. 分子生命化学セミナー 1B

    2020

  15. 分子生命化学セミナー 1A

    2020

  16. 生物機能工学演習

    2020

  17. 化学生命工学実験2

    2020

  18. 分子生命化学基礎論

    2020

  19. 生化学1および演習

    2019

  20. 基礎化学実験

    2019

  21. 実験安全学

    2019

  22. 基礎化学実験

    2018

  23. 生化学1および演習

    2018

  24. 分子生命化学基礎論

    2018

  25. 生化学1および演習

    2017

  26. 基礎化学実験

    2017

  27. 分析化学実験第一

    2017

  28. Core Biochemistry

    2017

  29. 分析化学実験第一

    2016

  30. 生物機能工学演習

    2015

  31. 生物機能工学実験

    2015

  32. 分析化学実験第一

    2015

▼display all

 

Social Contribution 4

  1. テクノWebinar名大 座談会

    Role(s):Panelist

    名古屋大学工学部  テクノWebinar名大  2020.11

     More details

    Audience: Junior students, High school students

  2. 女子中高生向けサイエンスカフェ「物理や化学で紐解く生命科学の魅力」

    Role(s):Appearance, Presenter, Lecturer

    2018.3

  3. 女子中高生向けサイエンスカフェ「物理や化学で紐解く生命科学の魅力」

    2015.11

  4. 女子中高生向けサイエンスカフェ「物理や化学で紐解く生命科学の魅力」

    2015.3

Media Coverage 1

  1. 先端人 Newspaper, magazine

    朝日新聞  朝日新聞 名古屋本社版  30面(東海経済)  2020.1

     More details

    Author:Myself