Updated on 2026/03/04

写真a

 
OKUMURA Eriko
 
Organization
Nagoya University Hospital Neurosurgery Lecturer of hospital
Title
Lecturer of hospital

Degree 1

  1. Doctor (Medicine) ( 2012.10   Nagoya University ) 

Research Interests 1

  1. neurosurgery, CSF dynamics, hydrocephalus, hypothalamic and pituitary, neuroendoscopy

Research History 3

  1. Nagoya University   Nagoya University Hospital Neurosurgery   Lecturer of hospital

    2024.9

  2. Nagoya University Graduate School of Medicine, Endowed Chair   Designated Lecturer

    2023.5 - 2024.8

  3. Nagoya University   Endowed Chair Assistant Professor

    2011.11 - 2013.12

Professional Memberships 5

  1. 日本脳神経外科学会

  2. 日本脳神経外科コングレス

  3. 日本正常圧水頭症学会

  4. 日本間脳下垂体腫瘍学会

  5. 日本神経内視鏡学会

 

Papers 19

  1. Rapid intraoperative boundary diagnosis of somatotroph pituitary neuroendocrine tumors using real-time PCR.

    Sato Y, Takeuchi K, Ohka F, Nagata Y, Maeda S, Matsuyama T, Hirose T, Deguchi S, Okumura E, Iwami K, Saito R

    Acta neuropathologica communications     2026.2

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    Language:English  

    DOI: 10.1186/s40478-026-02255-5

    PubMed

  2. Two-stage surgery for cystic craniopharyngiomas: a purely endoscopic strategy and outcomes

    Sato, Y; Takeuchi, K; Nagata, Y; Matsuyama, T; Hirose, T; Okumura, E; Iwami, K; Saito, R

    PITUITARY   Vol. 29 ( 1 ) page: 21   2025.12

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    Language:English   Publisher:Pituitary  

    Purpose: This study aimed to evaluate the effectiveness and safety of two-stage endoscopic surgery for the complete resection of cystic craniopharyngiomas. Methods: We retrospectively evaluated 11 patients who underwent two-stage endoscopic surgery between March 2020 and July 2025. The lesions showed suprasellar and lateral extension toward the optic chiasm or the foramen of Monro, resulting in visual impairment or obstructive hydrocephalus. Cyst fenestration (CF) was initially performed using a transventricular approach with a flexible endoscope. One to two months later, endoscopic transsphenoidal surgery (eTSS) was performed to achieve complete resection. Tumor size (vertical diameter, horizontal diameter, and volume) was measured at three time points: pre-CF, post-CF (≤ 4 days), and pre-eTSS. Extent of resection, recurrence, and pituitary and hypothalamic function were assessed post-eTSS. Results: Complete resection was achieved in 10 of 11 patients, with no recurrence during a median follow-up of 22.8 months (range, 3.6–65.3). At a median interval of 54 days (range, 27–86) between CF and eTSS, the mean linear reduction was 45.3% superiorly and 39.3% laterally; mean tumor volume decreased by 68.0%. In some cases, areas typically difficult to access via eTSS alone decreased in size. All preoperative symptoms, except for hypopituitarism and diabetes insipidus, improved immediately after CF. No hypothalamic dysfunction was observed. Conclusion: Two-stage endoscopic surgery for cystic craniopharyngiomas is effective and safe, enabling complete resection with low recurrence during short- to mid-term follow-up.

    DOI: 10.1007/s11102-025-01618-w

    Web of Science

    Scopus

    PubMed

  3. Surgical Strategies for Giant Pituitary Adenomas to Minimize Postoperative Hematoma Formation Open Access

    NAGATA Yuichi, TAKEUCHI Kazuhito, IWAMI Kenichiro, OKUMURA Eriko, SATO Yoshiki, HIROSE Toshiaki, SAITO Ryuta

    Neurologia medico-chirurgica   Vol. 65 ( 11 ) page: 532 - 539   2025.11

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    Language:English   Publisher:The Japan Neurosurgical Society  

    <p>Postoperative hematoma formation is one of the most life-threatening complications associated with giant pituitary adenomas, and various surgical methods have been proposed to mitigate this risk. This study aims to report our surgical outcomes in patients with giant pituitary adenomas and to identify risk factors associated with postoperative hematoma formation. We retrospectively reviewed 45 patients with giant pituitary adenomas who underwent surgical treatment. The surgical approaches included conventional transsphenoidal surgery in 24 patients, extended transsphenoidal surgery in 9, and simultaneous combined transsphenoidal surgery and transcranial surgery in 12. Intracapsular resection was performed in 28 patients, while extracapsular resection was carried out in 17 patients. Postoperative hematoma formation was observed in 17 patients; among them, 2 experienced neurological deterioration and subsequently required reoperation for hematoma evacuation. The mean maximum tumor diameter was significantly larger in patients with postoperative hematoma (54 mm) compared to those without (45.3 mm) (p = 0.008). Other tumor characteristics were not significantly associated with postoperative hematoma formation. Combined transsphenoidal surgery and transcranial surgery were more frequently performed in patients who developed postoperative hematoma (p = 0.007), whereas extracapsular resection was more common in those without hematoma (p = 0.001). However, these differences in postoperative hemorrhage incidence among surgical techniques may have been substantially influenced by selection bias. Giant pituitary adenomas with extensive intracranial extension and involvement of critical neurovascular structures remain challenging to manage regardless of the surgical approach. Nevertheless, it is essential to tailor surgical strategies to individual cases to minimize postoperative complications.</p>

    DOI: 10.2176/jns-nmc.2025-0106

    Open Access

    Web of Science

    Scopus

    PubMed

    CiNii Research

  4. Intravenous perampanel in clinical practice: A multicenter prospective registry study

    Sato, Y; Iwami, K; Okumura, E; Ohka, F; Takeuchi, K; Deguchi, S; Nagata, Y; Muraoka, S; Ishizaki, T; Nagashima, Y; Shiba, Y; Kato, T; Tanbara, M; Kano, T; Nishizawa, T; Yamamoto, Y; Saito, R

    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY   Vol. 131   page: 334 - 339   2025.9

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    Language:English   Publisher:Seizure  

    Purpose: This study aimed to evaluate the efficacy and safety of intravenous perampanel (IV-PER) in routine clinical practice. Methods: Patients who received IV-PER at Nagoya University Hospital or one of the 21 affiliated institutions between June 2024 and March 2025 were included. Indications for IV-PER included treatment for epileptic seizures, particularly acute symptomatic seizures, and prophylactic use before or after surgery. The primary endpoint was the seizure suppression rate within 7 days of treatment initiation, and the secondary endpoint was the incidence of adverse events (AEs). Clinical data were recorded daily, and blood tests were conducted within 2 weeks of administration. Enrolled patients were categorized into three groups based on the underlying etiology: cerebrovascular disease (CD), brain tumor (BT), and traumatic brain injury (TBI). Treatment efficacy and safety were assessed across these groups. Results: Of the 237 patients, 74, 116, and 47 were classified into the CD, BT, and TBI groups, respectively. The overall seizure suppression rate within 7 days was 89.0 %. Rates by group were 87.8 % (CD), 96.6 % (BT), and 72.3 % (TBI). When stratified by indication, the rates were 99.3 % for prophylactic use, 69.4 % for focal seizures, and 74.4 % for generalized seizures. Regarding AEs, somnolence was reported in 3 patients and irritability in one. Laboratory abnormalities included anemia, elevated liver enzymes, elevated creatine kinase, and hyponatremia. A total of 71 patients experienced one of these. Conclusions: This large multicenter prospective registry demonstrates that IV-PER can be safely used for seizure management during the 7-day acute phase in real-world clinical settings.

    DOI: 10.1016/j.seizure.2025.07.023

    Web of Science

    Scopus

    PubMed

  5. 嚢胞性頭蓋咽頭腫に対する内視鏡での二期的手術

    佐藤 佳輝, 竹内 和人, 永田 雄一, 岩味 健一郎, 奥村 衣里子, 近藤 辰磨, 廣瀬 俊明, 齋藤 竜太

    日本内分泌学会雑誌   Vol. 101 ( S.HPT ) page: 11 - 12   2025.8

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    Language:Japanese   Publisher:一般社団法人 日本内分泌学会  

    DOI: 10.1507/endocrine.101.s.hpt_11

    CiNii Research

  6. 機能性下垂体腫瘍に対するreal-time PCR法での遺伝子解析を用いた正確な境界領域診断

    佐藤 佳輝, 竹内 和人, 大岡 史治, 永田 雄一, 岩味 健一郎, 奥村 衣里子, 近藤 辰磨, 廣瀬 俊明, 齋藤 竜太

    日本内分泌学会雑誌   Vol. 101 ( S.HPT ) page: 75 - 77   2025.8

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    Language:Japanese   Publisher:一般社団法人 日本内分泌学会  

    DOI: 10.1507/endocrine.101.s.hpt_75

    CiNii Research

  7. Endoscopic Cystoventricular Stenting in Awake Patients with Electrical Stimulation Mapping for Convexity Cysts: Three Case Reports and a Systematic Review Open Access

    Okumura, E; Takeuchi, K; Nagata, Y; Iwami, K; Motomura, K; Ohka, F; Sato, Y; Hirose, T; Saito, R

    WORLD NEUROSURGERY   Vol. 193   page: 108 - 118   2025.1

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    Language:English   Publisher:World Neurosurgery  

    Surgical interventions for arachnoid cysts and glioependymal cysts primarily focus on cyst decompression and establishing communication with cerebrospinal fluid spaces. However, a standardized surgical strategy for symptomatic convexity cysts lacking surrounding cerebrospinal fluid space is still lacking due to the limited number of cases. This systematic review aims to evaluate surgical interventions for symptomatic convexity cysts and proposes a safe and effective treatment approach we have developed. A systematic review of the literature was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Surgical techniques were categorized into cystoperitoneal shunt, cyst excision, cyst fenestration, cyst ventriculostomy, and several uniquely modified methods. Using a method different from these previous reports, we performed endoscopic cystoventricular stenting via burr hole in 3 cases of convexity cysts. While traditional methods have proven effective, cystoperitoneal shunt may lead to malfunction, infection, and subdural hematoma; wall excision is invasive and increases morbidity risks. Fenestration and cystoventriculostomy have also reported cases of recurrence. Other methods also pose issues, including off-label use of instruments and inadequate consideration for removal. The method we performed for placing the stent catheter with multiple side holes demonstrated long-term effectiveness. Furthermore, the surgery was conducted with the patient fully awake, and the use of electrical stimulation mapping enabled preservation of higher neurocognitive functions, including language, working memory, and spatial cognition, at the puncture site. This novel approach offers advantages such as minimally invasive procedure, preservation of safe brain function, and long-term patency. Further studies are warranted to validate these findings and improve surgical strategies for convexity cysts.

    DOI: 10.1016/j.wneu.2024.10.031

    Open Access

    Web of Science

    Scopus

    PubMed

  8. Data assimilation between Monte Carlo simulation and experimental results of crystal growth island density in REBCO thin films during the initial growth stages. Open Access

    Okumura E., Uchida H., Takamura T., Taoka N., Seike Y., Mori T., Ichino Y., Horio K., Ichinose A., Horide T., Matsumoto K., Yoshida Y.

    Journal of Physics Conference Series   Vol. 3054 ( 1 )   2025

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    Publisher:Journal of Physics Conference Series  

    YBCO superconductors offer high transition temperatures for applications. REBCO wires, made via pulsed laser deposition (PLD), are developed for various uses. However, optimizing PLD parameters is time-consuming. To resolve this, we aimed to develop the simulation of REBCO thin film growth with Monte Carlo algorithm and Bayesian optimization to find the optimal parameters. While current simulations show discrepancies with experiments, this approach sets the foundation for improved models and simulations.

    DOI: 10.1088/1742-6596/3054/1/012020

    Open Access

    Scopus

  9. Registry-Based Assessment of Shunt Operation Methods and Outcomes in Idiopathic Normal Pressure Hydrocephalus (RASHOMON Study): Protocol for a Multicenter Prospective Observational Cohort Study

    Okumura, E; Takeuchi, K; Momota, H; Nagatani, T; Taoka, T; Aimi, Y; Hashizume, A; Okazaki, M; Saito, R

    JMIR RESEARCH PROTOCOLS   Vol. 14   page: e80678   2025

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    Language:English  

    DOI: 10.2196/80678

    Web of Science

    PubMed

  10. Endoscopic Surgery for Brainstem Cavernous Malformations

    TAKEUCHI Kazuhito, NAGATA Yuichi, ITO Eiji, OKUMURA Eriko, HARADA Hideyuki, SAITO Ryuta

    Surgery for Cerebral Stroke   Vol. 53 ( 2 ) page: 108 - 113   2025

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    Language:Japanese   Publisher:The Japanese Society on Surgery for Cerebral Stroke  

    <p>The use of endoscopy in the treatment of brainstem cavernous malformations (BCMs) has been reported in a limited number of cases. Given its ability to provide a broad and bright field of view even in deep regions, endoscopy is considered effective for treating deep-seated lesions, such as BCMs, and has been actively utilized in our institute.</p><p>This study retrospectively reviewed 32 cases of BCMs treated with endoscopic techniques (midbrain, 7 cases; pons, 22 cases; and medulla, 3 cases). The approach routes to the brainstem were based on the “Two Point Method,” primarily utilizing the nearby safe entry zones. Surgical removal was performed through transnasal procedures in 5 cases and craniotomy in 27 cases, with 25 of these employing small diameter cylinders to secure the surgical corridor. Gross total resection was achieved in 30 cases (93.8%). Postoperative complications were observed in five cases. The average Karnofsky Performance Status improved from 62.2 preoperatively to 84.4 3 months postoperatively, with improvements in 26 cases, no change in 5 cases, and deterioration in 1 case. Surgical treatments for BCMs are predominantly performed under a microscope; however, the outcomes of endoscopic surgery in this study showed favorable neurological prognoses compared with the findings of previous reports. The use of endoscopy facilitated the minimization of surgical pathways and enabled underwater surgery, thereby establishing a novel approach that is not preferably available in microscopic surgery. Underwater intraoperative observation, a distinctive feature of endoscopic surgery, was highly effective in identifying residual lesions and achieving hemostasis. Despite its advantages, endoscopy presents challenges, prompting ongoing developments and improvements in surgical instruments and techniques. Although this technique is still evolving, the utility of endoscopy for treating BCMs is promising.</p>

    DOI: 10.2335/scs.53.108

    CiNii Research

  11. A Case of Papillary Craniopharyngioma Mimicking Rathke's Cleft Cyst Open Access

    HARADA Hideyuki, TAKEUCHI Kazuhito, NAGATA Yuichi, INOSHITA Naoko, ITO Eiji, OKUMURA Eriko, KONDO Tatsuma, SATO Yoshiki, SAITO Ryuta

    NMC Case Report Journal   Vol. 11 ( 0 ) page: 191 - 194   2024.12

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    Language:English   Publisher:The Japan Neurosurgical Society  

    <p>Craniopharyngioma (CP) and Rathke's cleft cyst (RCC) are both suprasellar lesions. They are sometimes difficult to distinguish due to their similar findings. We report a case of papillary craniopharyngioma (pCP) with the clinical findings suggesting RCC. A 42-year-old female with intellectual disability presented to our hospital with severe visual dysfunction. Preoperative images revealed a suprasellar cystic lesion without calcification. We performed transsphenoidal surgery. Since the cyst had condensed-milk-like content suggesting RCC, we performed cyst fenestration and wash without removal of the cyst wall. Thereafter, we found fish-egg-like structures on the cyst wall. The histopathological analysis revealed that they had papillary structures surrounded by hyperplastic squamous epithelium with parakeratosis. Immunostaining for BRAF V600E was positive, leading to the diagnosis of pCP. After the surgery, her visual function improved and follow-up Magnetic resonance imaging at 18 months postoperatively showed no apparent recurrence. The presence of condensed-milk-like content suggests a likelihood of RCC indicating that aggressive resection may not be necessary. In contrast, the existence of fish-egg-like structures suggests pCP and requires careful follow-up.</p>

    DOI: 10.2176/jns-nmc.2024-0057

    Open Access

    PubMed

    CiNii Research

  12. Cylinder tumor surgery in pediatric low-grade gliomas

    Jaimovich, SG; Takeuchi, K; Testa, VT; Okumura, E; Jaimovich, R; Cinalli, G

    CHILDS NERVOUS SYSTEM   Vol. 40 ( 10 ) page: 3051 - 3063   2024.10

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    Language:English   Publisher:Child S Nervous System  

    Background: Periventricular pediatric low-grade gliomas (pLGG) present a surgical challenge due to their deep-seated location, accessibility, and relationship with the subcortical network connections. Minimally invasive parafascicular approaches with tubular brain retractors (port brain surgery) have emerged, in recent years, as an alternative to conventional microsurgical and endoscopic approaches for removal of periventricular tumors. Objectives: To describe the minimally invasive approach with tubular brain retractors for periventricular pLGG, its technique, applications, safety, and efficacy. Methods: In this article, we describe the port brain surgery techniques for periventricular pLGG as performed in different centers, with different commercialized tubular retractor systems. Illustrative cases followed by a literature review are analyzed, with a detailed description of different approaches or techniques, comparing their advantages and disadvantages with contemporary microsurgical and endoscopic approaches. Conclusions: The port brain surgery with micro-exoscopic vision and endoscopic assistance, for the treatment of deep-seated lesions such as periventricular pLGG, is an alternative for achieving a functionally safe—gross total or subtotal—tumor resection, obtaining adequate tissue for pathological examination. This technique could offer a new dimension for a less-invasive, safe, and effective access to deep-seated tumors, offering the possibility to lower morbidity in experienced hands.

    DOI: 10.1007/s00381-024-06417-5

    Web of Science

    Scopus

    PubMed

  13. Quality of Life Changes Before and After Transsphenoidal Surgery for Sellar and Parasellar Lesions.

    World neurosurgery     2019.2

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  14. A Purely Endoscopic and Simultaneous Transsphenoidal and Transcranial Keyhole Approach for Giant Pituitary Adenoma Resection: A Technical Case Report.

    NMC case report journal     2015.7

  15. A novel method for managing water and electrolyte balance after transsphenoidal surgery: preliminary study of moderate water intake restriction. Open Access

    Nagoya journal of medical science     2014.2

  16. Quality of life in nonfunctioning pituitary macroadenoma patients before and after surgical treatment.

    Acta neurochirurgica     2012.10

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  17. [Use of high-dose dexmedetomidine infusion for anesthesia and sedation in a patient for microlaryngeal surgery maintained with spontaneous breathing].

    Masui. The Japanese journal of anesthesiology     2008.4

  18. Repetitive acute shock following tracheal extubations after neurosurgery for a cerebellar tumor.

    Journal of anesthesia     2006.2

  19. [Overdose of vecuronium during general anesthesia to an infant].

    Masui. The Japanese journal of anesthesiology     2005.3

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MISC 8

  1. Combined surgeryの際に開頭側から観察された経鼻手術操作の実際

    [若林 健一,渡邉 督,竹内 和人,永田 雄一,芝 良樹,清水 浩之,奥村 衣里子,原口 健一,雄山 博文]

        2016.6

  2. 生検を要した小児tumefactive demyelinationの1例

    [若林 健一,真島 久和,伊藤 剛,中道 玲瑛,前多 松喜,芝 良樹,清水 浩之,奥村 衣里子,原口 健一,雄山 博文]

        2016.5

  3. 巨細胞性動脈炎(側頭動脈炎)の2例

    [芝 良樹,雄山 博文,若林 健一,原口 健一,奥村 衣里子,清水 浩之]

        2016.3

  4. 難治性慢性硬膜下血腫に対し、中硬膜動脈の塞栓術を行った3例の報告

    [雄山 博文,原口 健一,芝 良樹,清水 浩之,若林 健一,奥村 衣里子]

        2016.2

  5. VPシャントに伴う腹腔内髄液仮性嚢胞の1例

    [若林 健一,田中 達之,前多 松喜,村瀬 成彦,芝 良樹,清水 浩之,小笠原 康伸,佐藤 雅基,奥村 衣里子,原口 健一,雄山 博文,井上 憲夫]

        2015.5

  6. CEAとCASの周術期合併症と術後DWI陽性率についての検討

    [原口 健一,井上 憲夫,雄山 博文,若林 健一,奥村 衣里子,小笠原 康伸,清水 浩之,芝 良樹]

        2014.12

  7. 【大事なことだけギュギュッと凝縮!脳神経疾患&治療 まるわかり帳】治療編 脳室ドレナージ術 シャント術

    [奥村 衣里子]

        2014.4

  8. 小児用腹腔鏡下に腹腔カテーテル留置を行った水頭症の1例

    [奥村 衣里子,永谷 哲也,竹内 和人,佐藤 祐介,丹原 正夫,長坂 昌登,若林 俊彦]

        2013.4

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Teaching Experience (On-campus) 2

  1. PBLチュートリアル

    2024年度

  2. PBLチュートリアルまとめセッション

    2024年度