研究者詳細 - 上川内　あづさ

論文 - 上川内　あづさ

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Mate Discrimination of Colocasiomyia xenalocasiae and C. alocasiae (Diptera: Drosophilidae) as a Possible Factor Contributing to their Co-Existence on the Same Host Plant 査読有り

Tanaka, R; Takekata, H; Ishikawa, Y; Kamikouchi, A

JOURNAL OF INSECT BEHAVIOR 35 巻 ( 1-3 ) 頁： 44 - 55 2022年5月

Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila 査読有り国際誌

Lee, TT; Chen, PL; Su, MP; Li, JC; Chang, YW; Liu, RW; Juan, HF; Yang, JM; Chan, SP; Tsai, YC; von Stockum, S; Ziviani, E; Kamikouchi, A; Wang, HD; Chen, CH

AGING CELL 20 巻 ( 6 ) 頁： e13379 2021年6月

Molecular and neural mechanisms regulating sexual motivation of virgin female Drosophila 招待有り査読有り国際誌

Ishimoto, H; Kamikouchi, A

CELLULAR AND MOLECULAR LIFE SCIENCES 78 巻 ( 10 ) 頁： 4805 - 4819 2021年5月

Distinct subpopulations of mechanosensory chordotonal organ neurons elicit grooming of the fruit fly antennae 査読有り国際共著国際誌

Hampel, S; Eichler, K; Yamada, D; Bock, DD; Kamikouchi, A; Seeds, AM

ELIFE 9 巻 2020年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Diverse mechanosensory neurons detect different mechanical forces that can impact animal behavior. Yet our understanding of the anatomical and physiological diversity of these neurons and the behaviors that they influence is limited. We previously discovered that grooming of the Drosophila melanogaster antennae is elicited by an antennal mechanosensory chordotonal organ, the Johnston's organ (JO) (Hampel et al., 2015). Here, we describe anatomically and physiologically distinct JO mechanosensory neuron subpopulations that each elicit antennal grooming. We show that the subpopulations project to different, discrete zones in the brain and differ in their responses to mechanical stimulation of the antennae. Although activation of each subpopulation elicits antennal grooming, distinct subpopulations also elicit the additional behaviors of wing flapping or backward locomotion. Our results provide a comprehensive description of the diversity of mechanosensory neurons in the JO, and reveal that distinct JO subpopulations can elicit both common and distinct behavioral responses.

DOI： 10.7554/eLife.59976

Web of Science

PubMed

Wiring patterns from auditory sensory neurons to the escape and song-relay pathways in fruit flies 査読有り国際共著国際誌

Kim, H; Horigome, M; Ishikawa, Y; Li, F; Lauritzen, JS; Card, G; Bock, DD; Kamikouchi, A

JOURNAL OF COMPARATIVE NEUROLOGY 528 巻 ( 12 ) 頁： 2068 - 2098 2020年8月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Many animals rely on acoustic cues to decide what action to take next. Unraveling the wiring patterns of the auditory neural pathways is prerequisite for understanding such information processing. Here we reconstructed the first step of the auditory neural pathway in the fruit fly brain, from primary to secondary auditory neurons, at the resolution of transmission electron microscopy. By tracing axons of two major subgroups of auditory sensory neurons in fruit flies, low-frequency tuned Johnston's organ (JO)-B neurons and high-frequency tuned JO-A neurons, we observed extensive connections from JO-B neurons to the main second-order neurons in both the song-relay and escape pathways. In contrast, JO-A neurons connected strongly to a neuron in the escape pathway. Our findings suggest that heterogeneous JO neuronal populations could be recruited to modify escape behavior whereas only specific JO neurons contribute to courtship behavior. We also found that all JO neurons have postsynaptic sites at their axons. Presynaptic modulation at the output sites of JO neurons could affect information processing of the auditory neural pathway in flies. This article is protected by copyright. All rights reserved.

DOI： 10.1002/cne.24877

Web of Science

PubMed

Auditory experience prevents loss of the innate song preference as a selective cue inDrosophila

bioRxiv 2020年7月

Convergence of distinct subpopulations of mechanosensory neurons onto a neural circuit that elicits grooming

Stefanie Hampel, Katharina Eichler, Daichi Yamada, Hyunsoo Kim, Mihoko Horigome, Romain Franconville, Davi D. Bock, Azusa Kamikouchi, Andrew M. Seeds

2020年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cold Spring Harbor Laboratory

<jats:title>Abstract</jats:title><jats:p>Diverse subpopulations of mechanosensory neurons detect different mechanical forces and influence behavior. How these subpopulations connect with central circuits to influence behavior remains an important area of study. We previously discovered a neural circuit that elicits grooming of the<jats:italic>Drosophila melanogaster</jats:italic>antennae that is activated by an antennal mechanosensory chordotonal organ, the Johnston’s organ (JO) (Hampel et al., 2015). Here, we describe anatomically and physiologically distinct JO mechanosensory neuron subpopulations and define how they interface with the circuit that elicits antennal grooming. We show that the subpopulations project to distinct zones in the brain and differ in their responses to mechanical stimulation of the antennae. Each subpopulation elicits grooming through direct synaptic connections with a single interneuron in the circuit, the dendrites of which span the different mechanosensory afferent projection zones. Thus, distinct JO subpopulations converge onto the same neural circuit to elicit a common behavioral response.</jats:p>

DOI： 10.1101/2020.06.08.141341

Stereotyped Combination of Hearing and Wind/Gravity-Sensing Neurons in the Johnston's Organ of Drosophila 査読有り国際共著国際誌

Ishikawa, Y; Fujiwara, M; Wong, J; Ura, A; Kamikouchi, A

FRONTIERS IN PHYSIOLOGY 10 巻頁： 1552 - 1552 2020年1月

2.50 - Drosophila as a Model for Hearing and Deafness

Albert, J.T., Jarman, A.P., Kamikouchi, A., Keder, A.

The Senses: A Comprehensive Reference: Volume 1-7, Second Edition 2 巻 2020年

STEFTR: A Hybrid Versatile Method for State Estimation and Feature Extraction From the Trajectory of Animal Behavior 査読有り国際共著国際誌

Yamazaki, SJ; Ohara, K; Ito, K; Kokubun, N; Kitanishi, T; Takaichi, D; Yamada, Y; Ikejiri, Y; Hiramatsu, F; Fujita, K; Tanimoto, Y; Yamazoe-Umemoto, A; Hashimoto, K; Sato, K; Yoda, K; Takahashi, A; Ishikawa, Y; Kamikouchi, A; Hiryu, S; Maekawa, T; Kimura, KD

FRONTIERS IN NEUROSCIENCE 13 巻頁： 626 - 626 2019年6月