Organization
Graduate School of Science Neuroscience Institute Lecturer
Graduate School
Graduate School of Science
Undergraduate School
School of Science Department of Biological Science
Title
Lecturer
Contact information
NAKANO Shunji
Degree 1
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Ph. D. (Biology) （ 2011.2 Massachusetts Institute of Technology ）
Education 1
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Massachusetts Institute of Technology Graduate School, Division of Bioresearch
- 2011.2
Country： United States
Papers 31
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Replication-coupled chromatin assembly generates a bilateral asymmetry in C.elegans neuroanatomy Reviewed
Shunji Nakano, Bruce Stillman, H. Robert Horvitz
Cell Vol. 147 ( 7 ) page： 1525 - 1536 2011.12
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Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans Reviewed
Shunji Nakano, Ronald E. Ellis, H. Robert Horvitz
Development Vol. 137 page： 4017-4027 2010
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A regulatory protein that interferes with activator-stimulated transcription in bacteria.
Nakano, S., Nakano, M. M., Zhang, Y., Leelakriangsak, M., and Zuber, P.
Proc Natl Acad Sci USA Vol. 100 page： 4233-4238 2003
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Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis.
Nakano, S., Kuster-Schock, E., Grossman, A. D., and Zuber, P.
Proc Natl Acad Sci USA Vol. 100 page： 13603-13608 2003
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A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in Caenorhabditis elegans
Airi Nakayama, Masakatsu Watanabe, Riku Yamashiro, Hiroo Kuroyanagi, Atsunori Oshima, Ikue Mori, Shunji Nakano
bioRxiv page： 2023.08.21.554224 2023.8
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Higurashi, S; Tsukada, S; Aleogho, BM; Park, JH; Al-Hebri, Y; Tanaka, M; Nakano, S; Mori, I; Noma, K
ELIFE Vol. 12 2023.5
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AWC thermosensory neuron interferes with information processing in a compact circuit regulating temperature-evoked posture dynamics in the nematode Caenorhabditis elegans Reviewed
Amane Kano, Hironori J Matsuyama, Shunji Nakano, Ikue Mori
Neuroscience Research Vol. 188 page： 10 - 27 2023.3
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Kano, A; Matsuyama, HJ; Nakano, S; Mori, I
NEUROSCIENCE RESEARCH Vol. 188 page： 10 - 27 2023.3
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cGMP dynamics that underlies thermosensation in temperature-sensing neuron regulates thermotaxis behavior in C. elegans Reviewed
Ichiro Aoki Makoto Shiota, Yuki Tsukada, Shunji Nakano, Ikue Mori
PLoS One Vol. 17 ( 12 ) page： e0278343 2022.12
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Aok, I; Shiota, M; Tsukada, Y; Nakano, S; Mori, I
PLOS ONE Vol. 17 ( 12 ) 2022.12
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Nakano, S; Nakayama, A; Kuroyanagi, H; Yamashiro, R; Tsukada, Y; Mori, I
G3-GENES GENOMES GENETICS Vol. 12 ( 11 ) 2022.11
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Aoki, I; Jurado, P; Nawa, K; Kondo, R; Yamashiro, R; Matsuyama, HJ; Ferrer, I; Nakano, S; Mori, I
PLOS GENETICS Vol. 18 ( 6 ) 2022.6
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Ikeda, M; Nakano, S; Giles, AC; Xu, LH; Costa, WS; Gottschalk, A; Mori, I
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 117 ( 11 ) page： 6178 - 6188 2020.3
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Tsukamoto, S; Emmei, T; Nakano, S; Nishio, N; Sasakura, H; Mori, I
GENES TO CELLS Vol. 25 ( 3 ) page： 154 - 164 2020.3
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Nakano, S; Ikeda, M; Tsukada, Y; Fei, XF; Suzuki, T; Niino, Y; Ahluwalia, R; Sano, A; Kondo, R; Ihara, K; Miyawaki, A; Hashimoto, K; Higashiyama, T; Mori, I
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 117 ( 3 ) page： 1638 - 1647 2020.1
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IKenaka, K; Tsukada, Y; Giles, AC; Arai, T; Nakadera, Y; Nakano, S; Kawai, K; Mochizuki, H; Katsuno, M; Sobue, G; Mori, I
SCIENTIFIC REPORTS Vol. 9 2019.7
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An, SWA; Choi, ES; Hwang, W; Son, HG; Yang, JS; Seo, K; Nam, HJ; Nguyen, NTH; Kim, EJE; Suh, BK; Kim, Y; Nakano, S; Ryu, Y; Man Ha, C; Mori, I; Park, SK; Yoo, JY; Kim, S; Lee, SJV
AGING CELL Vol. 18 ( 3 ) 2019.6
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Identification of animal behavioral strategies by inverse reinforcement learning
Yamaguchi, S; Naoki, H; Ikeda, M; Tsukada, Y; Nakano, S; Mori, I; Ishii, S
PLOS COMPUTATIONAL BIOLOGY Vol. 14 ( 5 ) 2018.5
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SLO potassium channels antagonize premature decision making in <i>C</i>. <i>elegans</i>
Aoki, I; Tateyama, M; Shimomura, T; Ihara, K; Kubo, Y; Nakano, S; Mori, I
COMMUNICATIONS BIOLOGY Vol. 1 2018
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Single-Cell Memory Regulates a Neural Circuit for Sensory Behavior Reviewed
Kobayashi K, Nakano S, Amano M, Tsuboi D, Nishioka T, Ikeda S, Yokoyama G, Kaibuchi K, Mori I.
Cell Rep. Vol. 14 ( 1 ) page： 11-21 2016.1
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A glial K+/Cl- cotransporter modifies temperature-evoked dynamics in C. elegans sensory neurons Reviewed
Yoshida A., Nakano S., Suzuki T., Ihara K., Higashiyama T., Mori I.
Genes Brain and Behavior 2015
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The nitric oxide-responsive regulator NsrR controls ResDE-dependent gene expression Reviewed
Nakano, M. M., Geng, H., Nakano, S., and Kobayashi, K.
J Bacteriol Vol. 188 page： 5878-5887 2006
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Mutational analysis of the Bacillus subtilis RNA polymerase alpha C-terminal domain supports the interference model of Spx-dependent repression Reviewed
Zhang, Y., Nakano, S., Choi, S. Y., and Zuber, P.
J Bacteriol Vol. 188 page： 4300-4311 2006
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Redox-sensitive transcriptional control by a thiol/disulphide switch in the global regulator, Spx.
Nakano, S., Erwin, K. N., Ralle, M., and Zuber, P.
Mol Microbiol Vol. 55 page： 498-510 2005
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Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase. Reviewed
Newberry, K. J., Nakano, S., Zuber, P., and Brennan, R. G.
Proc Natl Acad Sci USA Vol. 102 page： 15839-15844 2005
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Sulfate-dependent repression of genes that function in organosulfur metabolism in Bacillus subtilis requires Spx. Reviewed
Erwin, K. N., Nakano, S., and Zuber, P.
J Bacteriol Vol. 187 page： 4042-4049 2005
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The ClpX chaperone modulates assembly of the tubulin-like protein FtsZ
Weart, R. B., Nakano, S., Lane, B. E., Zuber, P., and Levin, P. A.
Mol Microbiol Vol. 57 page： 238-249 2005
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Transcriptional activation by Bacillus subtilis ResD: tandem binding to target elements and phosphorylation-dependent and -independent transcriptional activation.
Geng, H., Nakano, S., and Nakano, M. M.
J Bacteriol Vol. 186 page： 2028-2037 2004
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SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.
Tanaka-Hino, M., Sagasti, A., Hisamoto, N., Kawasaki, M., Nakano, S., Ninomiya-Tsuji, J., Bargmann, C. I., and Matsumoto, K.
EMBO Rep Vol. 3 page： 56-62 2002
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Spx (YjbD), a negative effector of competence in Bacillus subtilis, enhances ClpC-MecA-ComK Interaction.
Nakano, M. M., Nakano, S*. and Zuber, P.
Mol Microbiol Vol. 44 page： 1341-1349 2002
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Multiple pathways of Spx (YjbD) proteolysis in Bacillus subtilis.
Nakano, S., Zheng, G., Nakano, M. M., and Zuber, P.
J Bacteriol Vol. 188 page： 3664-3670 2002
Books 1
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Learning and Memory: A Comprehensive Reference
Aoki, I., Nakano, S., and Mori, I.（ Role： Joint author）
Elsevier 2017
Presentations 5
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Social contexts shape a decision-making through a gap junctional network in C. elegans International conference
Shunji Nakano
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Social contexts modulate C. elegans thermotaxis behavior
Shunji Nakano
24th International C. elegans conference 2023.6
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Social contexts shape a decision-making through a gap junctional network in C. elegans International conference
Shunji Nakano
2023.1.24
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A Non-Cell Autonomous Action of cGMP within Multi-Neuronal Network Regulates a C. elegans Navigation Behavior International conference
Shunji Nakano
The 45th annual meeting of the Japan neuroscience society 2022.7
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Presynaptic MAST Kinase Controls Bidirectional Post-Synaptic Responses to Convey Stimulus Valence during C. elegans Thermotaxis International conference
Shunji Nakano, Muneki Ikeda, Yuki Tsukada, Xianfeng Fei, Takamasa Suzuki, Rhea Ahluwalia, Ayana Sano, Rumi Kondo, Kunio Ihara, Koichi Hashimoto, Tetsuya Higashiyama & Ikue Mori
22nd International C.elegans Conference 2019.6
KAKENHI (Grants-in-Aid for Scientific Research) 3
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Neural communication responsible for determining the valence of sensory stimuli
Grant number：21H02525 2021.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Principal investigator
Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）
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行動モードの相転移を実現する脳情報動態
Grant number：18H05123 2018.6 - 2020.3
新学術領域研究(研究領域提案型)
中野 俊詩
Authorship：Principal investigator
Grant amount：\5590000 （ Direct Cost: \4300000 、 Indirect Cost：\1290000 ）
線虫C. elegans の2つの行動様式、「ローカルサーチ」と「グローバルサーチ」の違いを特徴付ける行動要素として、後退や急激な方向転換などのターン運動の頻度が挙げられる。すなわち、ローカルサーチモードではターン運動の頻度が上昇し、方向転換を繰り返しながら局所的な探索運動を繰り返すのに対し、グローバルサーチモードでは、方向転換の頻度を著しく減少させることで、より広範な範囲を探索する。最終年度においては、これらの後退などの方向転換運動を制御する神経回路を同定することに成功した。具体的には、行動中の多数の線虫個体をトラッキングするMulti worm tracking システムを駆使して、細胞死を誘導するキャスパーぜやminiSOGなどの遺伝学的手法によって、神経回路への摂動をあたえた集団から行動データを取得した。これらの行動データに対してシミュレーションを用いた解析を行い、ここの行動要素に重要な神経細胞を絞り込むことで、それぞれの行動要素の制御に関与する神経回路を明らかにすることに成功した。これらの解析から、後退や急激な方向転換などの単一の行動要素であっても、線虫が置かれた温度環境に応じて、異なる神経回路が行動制御に関与していることを見出した。また、温度環境に応じた行動制御には、感覚ニューロンと介在ニューロン間の情報伝達様式に変容が生じることが重要であることを明らかにした。これらの研究成果を、とりまとめ、論文発表を行った。(Ikeda et al, PNAS, 2020)。
令和元年度が最終年度であるため、記入しない。
令和元年度が最終年度であるため、記入しない。 -
Bidirectional regulation of synaptic transmission during C. elegans thermotaxis behavior
Grant number：17K07499 2017.4 - 2020.3
Nakano Shunji
Authorship：Principal investigator
Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）
Synaptic transmission is fundamental in information processing in the nervous system. This study focused a thermosensory neuron in the nematode C. elegans and its post-synaptic interneuron and aimed to understand the molecular basis of the neural communication between these neurons. We identified a series of evolutionarily conserved molecules that function in the thermosensory neuron to bidirectionally regulate the activity of the interneuron. Our results identified previously unknown factors important for synaptic transmission and revealed the potential therapeutic targets for information processing in the nervous system.
Teaching Experience (On-campus) 6
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Cell Biology III
2023
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Physiology and Anatomy II
2023
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Cell Biology III
2022
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Physiology and Anatomy II
2022
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Cell Biology III
2021
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Biochemistry I
2020
Social Contribution 1
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岐阜県立多治見北高等学校 オンライン講座
Role(s)：Lecturer
Media Coverage 3
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線虫の「好き嫌い」の仕組み Newspaper, magazine
朝日新聞 2020.2
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判断の仕組み解明 Newspaper, magazine
毎日新聞 2020.1
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温度「好き嫌い」仕組み解明 Newspaper, magazine
読売新聞 2020.1