Updated on 2023/09/19

写真a

 
SHINDO Yuichiro
 
Organization
Nagoya University Hospital Respiratory Medicine Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer
Contact information
メールアドレス

Degree 1

  1. M.D., Ph.D. (Medicine) ( 2011.3   Nagoya University ) 

Research Interests 7

  1. 呼吸器感染症

  2. COVID-19

  3. 免疫療法

  4. 感染免疫

  5. 薬剤耐性

  6. 抗微生物治療

  7. 肺炎

Research Areas 1

  1. Others / Others  / Respiratory Medicine

Research History 5

  1. Nagoya University   Department of Respiratory Medicine, Nagoya University Hospital   Lecturer

    2023.4

  2. Nagoya University   Department of Respiratory Medicine, Nagoya University Hospital   Lecturer of hospital

    2022.10 - 2023.3

  3. Nagoya University   Department of Respiratory Medicine, Nagoya University Hospital   Assistant Professor

    2016.4 - 2022.9

  4. Nagoya University   Institute for Advanced Research,   Designated assistant professor

    2011.4 - 2016.3

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    Country:Japan

  5. Nagoya University   Graduate School of Medicine   Designated assistant professor

    2011.4 - 2016.3

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences   Department of Respiratory Medicine

    2007.4 - 2011.3

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    Country: Japan

  2. Miyazaki Medical College   Faculty of Medicine

    1995.4 - 2001.3

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    Country: Japan

Professional Memberships 14

  1. The Japanese Society of Internal Medicine

  2. The Japanese Respiratory Society

  3. The Japanese Association for Infectious Diseases

  4. Japanese Society of Chemotherapy

  5. The Japanese Society for Tuberculosis

  6. The Japanese Society of Intensive Care Medicine

  7. 日本環境感染学会

  8. The Japanese Society for Respiratory Care and Rehabilitation

  9. 日本臨床微生物学会

  10. The Japanese Society of Allergology

  11. American Thoracic Society

  12. American College of Chest Physician

    2013.10

  13. European Respiratory Society

  14. Japanese Section of the American College of Chest Physicians

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Committee Memberships 10

  1. 日本感染症学会   評議員  

    2023.6   

  2. 日本呼吸器学会   広報委員会委員  

    2022.4   

  3. 日本呼吸器学会   「ストップ肺炎」推進委員会 委員  

    2020.11   

  4. 日本呼吸器学会   COVID-19診療エキスパートオピニオン ワーキンググループ 委員  

    2020.11   

  5. 日本呼吸器学会   肺炎診療ガイドライン作成委員会 委員  

    2020.11   

  6. 日本感染症学会   気道感染症抗菌薬適正使用委員会委員  

    2018.9   

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    Committee type:Academic society

  7. 日本結核・非結核性抗酸菌症学会   結核診療ガイドライン統括委員会 委員  

    2018.6   

  8. 日本結核・非結核性抗酸菌症学会   代議員  

    2018.3   

  9. 日本呼吸器学会   「ストップ肺炎」推進委員会 委員  

    2012.2 - 2013.1   

  10. 日本呼吸器学会   医療・介護関連肺炎診療ガイドライン作成委員会 委員  

    2009.11 - 2011.8   

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Awards 6

  1. JRS Young Scientist Award

    2021.11   Asian Pacific Society of Respirology  

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    Award type:International academic award (Japan or overseas) 

  2. 平成26年度日本呼吸器学会 学会奨励賞

    2015.4   日本呼吸器学会  

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    Country:Japan

  3. The 2009 Research Award of Japanese Section of the American College of Chest Physicians

    2010.10   Japanese Section of the American College of Chest Physicians  

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    Country:Japan

  4. MTPI ATS Abstract Scholarship Travel Award

    2014.5   American Thoracic Society   Mortality Risks In Patients With Pneumonia Who Received Appropriate Initial Antibiotics

    Shindo Y.

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    Award type:Award from international society, conference, symposium, etc.  Country:United States

  5. 第12回(2012年度)内藤記念若手研究者海外派遣助成金(秋季)

    2012.9   公益財団法人 内藤記念科学振興財団  

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    Country:Japan

  6. Young Investigator Award to the ATS (American Thoracic Society) 2009

    2009.2   Japanese Respiratory Society  

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    Country:Japan

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Papers 111

  1. Risk factors for 30-day mortality in patients with pneumonia who receive appropriate initial antibiotics: an observational cohort study Reviewed International journal

    Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, and Hasegawa Y

    Lancet Infect Dis   Vol. 15 ( 9 ) page: 1055 - 1065   2015.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S1473-3099(15)00151-6

    PubMed

  2. Risk Factors for Drug-Resistant Pathogens in Community-Acquired and Healthcare-Associated Pneumonia Reviewed

    Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Shiraki A, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, and Hasegawa Y, on behalf of the Central Japan Lung Study Group.

    Am J Respir Crit Care Med     page: [Epub ahead of print]   2013

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  3. Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia Reviewed International coauthorship

    Shindo Y*, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CA, Green JM., Morre M, Bochicchio GV, and Hotchkiss RS

    J Leukoc Biol   Vol. 101   page: 531-542   2017

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  4. Phase II Clinical Trial of Combination Therapy with Favipiravir and Methylprednisolone for COVID-19 with Non-Critical Respiratory Failure Reviewed

    Shindo Yuichiro, Kondoh Yasuhiro, Kada Akiko, Doi Yohei, Tomii Keisuke, Mukae Hiroshi, Murata Naohiko, Imai Ryosuke, Okamoto Masaki, Yamano Yasuhiko, Miyazaki Yasunari, Shinoda Masahiro, Aso Hiromichi, Izumi Shinyu, Ishii Haruyuki, Ito Ryota, Saito Akiko M., Saito Toshiki I, Hasegawa Yoshinori

    INFECTIOUS DISEASES AND THERAPY   Vol. 10 ( 4 ) page: 2353 - 2369   2021.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s40121-021-00512-9

    Web of Science

    PubMed

  5. Anti-Programed Cell Death Ligand 1 Peptide Improves Survival in Sepsis Reviewed International coauthorship

    Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, and Hotchkiss RS

    J Surg Res   Vol. 2017   page: 33-39   2017

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  6. Interleukin 7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression Reviewed International coauthorship International journal

    Shindo Y, Unsinger J, Burnham C, Green J, and Hotchkiss R

    Shock   Vol. 43 ( 4 ) page: 334 - 43   2015.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/SHK.0000000000000317

    Web of Science

    PubMed

  7. T cells from Patients with Candida Sepsis Display a Suppressive Immunophenotype Reviewed International coauthorship International journal

    Spec A, Shindo Y, Burnham CD, Wilson S, Ablordeppey E, Beiter ER, Chang K, Drewry AM, Hotchkiss RS.

    Crit Care   Vol. 20 ( 1 ) page: 15   2016.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13054-016-1182-z

    PubMed

  8. Extended-spectrum antibiotics for community-acquired pneumonia with a low risk for drug-resistant pathogens. Reviewed International journal

    Kobayashi H, Shindo Y, Kobayashi D, Sakakibara T, Murakami Y, Yagi M, Matsuura A, Sato K, Matsui K, Emoto R, Yagi T, Saka H, Matsui S, Hasegawa Y, Central Japan Lung Study Group.

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   Vol. 124   page: 124 - 132   2022.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijid.2022.09.015

    PubMed

  9. Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Reviewed International coauthorship

    Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG

    Annals of the American Thoracic Society   Vol. 18 ( 7 ) page: 1087 - 1097   2021.7

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    Language:English  

    DOI: 10.1513/AnnalsATS.202102-209ST

    PubMed

  10. International Perspective on the New 2019 American Thoracic Society/Infectious Diseases Society of America Community-Acquired Pneumonia Guideline: A Critical Appraisal by a Global Expert Panel. Reviewed International coauthorship

    Pletz MW, Blasi F, Chalmers JD, Dela Cruz CS, Feldman C, Luna CM, Ramirez JA, Shindo Y, Stolz D, Torres A, Webb B, Welte T, Wunderink R, Aliberti S

    Chest   Vol. 158 ( 5 ) page: 1912 - 1918   2020.11

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  11. Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia. Reviewed International journal

    Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Shiraki A, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, Hasegawa Y

    American journal of respiratory and critical care medicine   Vol. 188 ( 8 ) page: 985 - 95   2013.10

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1164/rccm.201301-0079OC

    PubMed

  12. Health-care-associated pneumonia among hospitalized patients in a Japanese community hospital. Reviewed International journal

    Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Hashimoto N, Imaizumi K, Sato T, Hasegawa Y

    Chest   Vol. 135 ( 3 ) page: 633 - 640   2009.3

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1378/chest.08-1357

    PubMed

  13. Inhalation adherence for asthma and COPD improved during the COVID-19 pandemic: a questionnaire survey at a university hospital in Japan Reviewed

    Fukutani E, Wakahara K, Nakamura S, Yokoi E, Yoshimi A, Miyazaki M, Nakamura M, Shindo Y, Sakamoto K, Okachi S, Tanaka I, Hamajima N, Noda Y, Hashimoto N, Ishii M

    J Asthma     page: 1 - 18   2023.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/02770903.2023.2209173

  14. Factors associated with adverse drug reactions or death in very elderly hospitalized patients with pulmonary tuberculosis. Reviewed International journal

    Yagi M, Shindo Y, Mutoh Y, Sano M, Sakakibara T, Kobayashi H, Matsuura A, Emoto R, Matsui S, Nakagawa T, Ogawa K

    Scientific reports   Vol. 13 ( 1 ) page: 6826   2023.4

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-33967-6

    PubMed

  15. 気管支拡張症における慢性感染の意義:その評価と治療 Invited

    進藤有一郎

    呼吸器内科   Vol. 43 ( 4 ) page: 382 - 386   2023.4

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  16. Identification of two specific transcriptomic clusters of COVID-19 acute respiratory distress syndrome patients with different immune profiles and different outcomes.

    Shindo Y, Dela Cruz CS, Witzenrath M

    The European respiratory journal   Vol. 61 ( 1 )   2023.1

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  17. Predicting oxygen requirements in patients with coronavirus disease 2019 using an artificial intelligence-clinician model based on local non-image data Reviewed

    Muto R, Fukuta S, Watanabe T, Shindo Y, Kanemitsu Y, Kajikawa S, Yonezawa T, Inoue T, Ichihashi T, Shiratori Y, Maruyama S

    Front Med   Vol. 9   page: 1042067   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.3389/fmed.2022.1042067

  18. Effects of lymphocyte and neutrophil counts and their time courses on mortality in patients with postoperative pneumonia. Reviewed

    Murakami Y, Shindo Y, Sano M, Okumura J, Kobayashi H, Sakakibara T, Iguchi M, Takahashi K, Yagi T, Matsui S, Hasegawa Y

    Scientific reports   Vol. 12 ( 1 ) page: 14564   2022.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-18794-5

    PubMed

  19. Risk factors for antibiotic resistance in hospital-acquired and ventilator-associated pneumonia

    Sano Masahiro, Shindo Yuichiro, Takahashi Kunihiko, Okumura Junya, Sakakibara Toshihiro, Murakami Yasushi, Iguchi Mitsutaka, Yagi Tetsuya, Matsui Shigeyuki, Hasegawa Yoshinori

    JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 28 ( 6 ) page: 745 - 752   2022.6

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  20. コロナ第七波に向けて 求められる医療体制とは Invited Reviewed

    進藤有一郎

    Medical Tribune   Vol. 55 ( 11 ) page: 3   2022.5

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    Language:Japanese  

  21. Broad-Spectrum Antibiotics and Mortality in Community-Acquired Pneumonia Patients with Low-Risk for Drug-Resistant Pathogens

    Kobayasi H., Shindo Y., Kobayashi D., Sakakibara T., Murakami Y., Yagi M., Matsuura A., Sato K., Goto Y., Matsui S., Yagi T., Saka H., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 205   2022.5

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  22. Clinical characteristics and risk factors for mortality in patients with community-acquired staphylococcal pneumonia.

    Thabet N, Shindo Y, Okumura J, Sano M, Sakakibara T, Murakami Y, Kobayashi H, Saka H, Kondo M, Hasegawa Y, Central Japan Lung Study Group.

    Nagoya journal of medical science   Vol. 84 ( 2 ) page: 247 - 259   2022.5

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    Language:English  

    DOI: 10.18999/nagjms.84.2.247

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  23. Successful Treatment with High-dose Steroids for Acute Exacerbation of Idiopathic Pulmonary Fibrosis Triggered by COVID-19.

    Omote N, Kanemitsu Y, Inoue T, Yonezawa T, Ichihashi T, Shindo Y, Sakamoto K, Ando A, Suzuki A, Niimi A, Ito S, Imaizumi K, Hashimoto N

    Internal medicine (Tokyo, Japan)   Vol. 61 ( 2 ) page: 233 - 236   2022.1

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    Language:English  

    DOI: 10.2169/internalmedicine.8163-21

    PubMed

  24. A prediction rule for severe adverse events in all inpatients with community-acquired pneumonia: a multicenter observational study.

    Sakakibara T, Shindo Y, Kobayashi D, Sano M, Okumura J, Murakami Y, Takahashi K, Matsui S, Yagi T, Saka H, Hasegawa Y

    BMC pulmonary medicine   Vol. 22 ( 1 ) page: 34   2022.1

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    Language:English  

    DOI: 10.1186/s12890-022-01819-0

    PubMed

  25. Distribution of serotypes and antibiotic resistance of invasive Pseudomonas aeruginosa in a multi-country collection.

    Nasrin S, Hegerle N, Sen S, Nkeze J, Sen S, Permala-Booth J, Choi M, Sinclair J, Tapia MD, Johnson JK, Sow SO, Thaden JT, Fowler VG Jr, Krogfelt KA, Brauner A, Protonotariou E, Christaki E, Shindo Y, Kwa AL, Shakoor S, Singh-Moodley A, Perovic O, Jacobs J, Lunguya O, Simon R, Cross AS, Tennant SM

    BMC microbiology   Vol. 22 ( 1 ) page: 13   2022.1

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    Language:English  

    DOI: 10.1186/s12866-021-02427-4

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  26. COVID-19-Triggered Acute Exacerbation of IPF, an Underdiagnosed Clinical Entity With Two-Peaked Respiratory Failure: A Case Report and Literature Review.

    Goto Y, Sakamoto K, Fukihara J, Suzuki A, Omote N, Ando A, Shindo Y, Hashimoto N

    Frontiers in medicine   Vol. 9   page: 815924   2022

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    Language:English  

    DOI: 10.3389/fmed.2022.815924

    PubMed

  27. The Mystery of Futility of Appropriate Antibiotics for Coinfection in COVID-19

    Kasugai Daisuke, Jingushi Naruhiro, Omote Norihiro, Shindo Yuichiro, Goto Yukari

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 204 ( 12 ) page: 1489 - 1489   2021.12

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  28. COVID-19の薬物療法のイロイロ Invited Reviewed

    進藤有一郎

    みんなの呼吸器Respica   Vol. 19 ( 6 ) page: 20 - 27   2021.12

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  29. 市中肺炎のマネージメント Invited

    進藤有一郎

    呼吸器内科   Vol. 39 ( 6 ) page: 465 - 470   2021.6

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  30. Usefulness of Respiratory Mechanics and Laboratory Parameter Trends as Markers of Early Treatment Success in Mechanically Ventilated Severe Coronavirus Disease: A Single-Center Pilot Study.

    Kasugai D, Ozaki M, Nishida K, Hiraiwa H, Jingushi N, Numaguchi A, Omote N, Shindo Y, Goto Y

    Journal of clinical medicine   Vol. 10 ( 11 )   2021.6

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    Language:English  

    DOI: 10.3390/jcm10112513

    PubMed

  31. 教えて!○○科のお医者さん 呼吸器内科 Invited

    進藤有一郎

    ニュートン別冊     page: 74 - 77   2021.6

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  32. Surgical Strategy and Optimal Timing of Tracheostomy in Patients with COVID-19: Early Experiences in Japan Invited Reviewed

    Nishio N, Hiramatsu M, Goto Y, Shindo Y, Yamamoto T, Jingushi N, Wakahara K, Sone M.

    Auris Nasus Larynx   Vol. 48 ( 3 ) page: 518 - 524   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.anl.2020.11.004

    DOI: 10.1016/j.anl.2020.11.004

    PubMed

  33. Corticosteroids for hospitalized patients with mild to critically-ill COVID-19: a multicenter, retrospective, propensity score-matched study.

    Ikeda S, Misumi T, Izumi S, Sakamoto K, Nishimura N, Ro S, Fukunaga K, Okamori S, Tachikawa N, Miyata N, Shinkai M, Shinoda M, Miyazaki Y, Iijima Y, Izumo T, Inomata M, Okamoto M, Yamaguchi T, Iwabuchi K, Masuda M, Takoi H, Oyamada Y, Fujitani S, Mineshita M, Ishii H, Nakagawa A, Yamaguchi N, Hibino M, Tsushima K, Nagai T, Ishikawa S, Ishikawa N, Kondoh Y, Yamazaki Y, Gocho K, Nishizawa T, Tsuzuku A, Yagi K, Shindo Y, Takeda Y, Yamanaka T, Ogura T

    Scientific reports   Vol. 11 ( 1 ) page: 10727   2021.5

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    Language:English  

    DOI: 10.1038/s41598-021-90246-y

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  34. Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality

    Nishikimi Mitsuaki, Nishida Kazuki, Shindo Yuichiro, Shoaib Muhammad, Kasugai Daisuke, Yasuda Yuma, Higashi Michiko, Numaguchi Atsushi, Yamamoto Takanori, Matsui Shigeyuki, Matsuda Naoyuki

    PLOS ONE   Vol. 16 ( 4 ) page: e0251030   2021.4

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  35. Never Let a Good Crisis Go to Waste. Reviewed International coauthorship

    Metersky M, Aliberti S, Feldman C, Luna C, Shindo Y, Sotgiu G, Waterer G.

    Chest   Vol. 159 ( 3 ) page: 917 - 919   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.chest.2020.10.018

    DOI: 10.1016/j.chest.2020.10.018

    PubMed

  36. 特集 新型コロナウイルス感染症IX オール愛知での診療体制を目指して. Invited

    進藤有一郎.

    名古屋医報   Vol. 1473   page: 2 - 3   2021.2

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  37. 呼吸器薬物療法―現場ではこう使いこなす― 抗菌薬:βラクタム薬、カルバペネム、モノバクタム、キノロン、アミノ配糖体、マクロライド、抗MRSA薬. Invited

    進藤有一郎.

    呼吸器ジャーナル   Vol. 69   page: 44 - 51   2021

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    Language:Japanese  

  38. Treatment of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies.

    Ramirez JA, Musher DM, Evans SE, Dela Cruz C, Crothers KA, Hage CA, Aliberti S, Anzueto A, Arancibia F, Arnold F, Azoulay E, Blasi F, Bordon J, Burdette S, Cao B, Cavallazzi R, Chalmers J, Charles P, Chastre J, Claessens YE, Dean N, Duval X, Fartoukh M, Feldman C, File T, Froes F, Furmanek S, Gnoni M, Lopardo G, Luna C, Maruyama T, Menendez R, Metersky M, Mildvan D, Mortensen E, Niederman MS, Pletz M, Rello J, Restrepo MI, Shindo Y, Torres A, Waterer G, Webb B, Welte T, Witzenrath M, Wunderink R

    Chest   Vol. 158 ( 5 ) page: 1896 - 1911   2020.11

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  39. Anesthetic and surgical management of tracheostomy in a patient with COVID-19.

    Hiramatsu M, Nishio N, Ozaki M, Shindo Y, Suzuki K, Yamamoto T, Fujimoto Y, Sone M

    Auris, nasus, larynx   Vol. 47 ( 3 ) page: 472 - 476   2020.6

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  40. Daily practice and prognostic factors for pneumonia caused by methicillin-resistant Staphylococcus aureus in Japan: A multicenter prospective observational cohort study

    Miyazaki Taiga, Yanagihara Katsunori, Kakeya Hiroshi, Izumikawa Koichi, Mukae Hiroshi, Shindo Yuichiro, Yamamoto Yoshihiro, Tateda Kazuhiro, Tomono Kazunori, Ishida Tadashi, Hasegawa Yoshinori, Niki Yoshihito, Watanabe Akira, Soma Kazui, Kohno Shigeru

    JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 26 ( 2 ) page: 242 - 251   2020.2

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  41. ER・ICUでの薬の使い方・考え方―エキスパートが実践する秘訣(コツ):市中肺炎/誤嚥性肺炎. Invited Reviewed

    進藤有一郎.

    救急・集中治療   Vol. 32   page: 672 - 677   2020

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  42. 呼吸器内科に必要な抗微生物薬の知識:アミノグリコシド系. Invited

    進藤有一郎.

    呼吸器内科   Vol. 37   page: 51 - 57   2020

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  43. 院内肺炎・人工呼吸器関連肺炎の治療―国内外のガイドラインと実臨床での考えかた. Invited

    進藤有一郎.

    Medicina   Vol. 57   page: 66 - 71   2020

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  44. The Diversity of Lipopolysaccharide (O) and Capsular Polysaccharide (K) Antigens of Invasive <i>Klebsiella pneumoniae</i> in a Multi-Country Collection.

    Choi M, Hegerle N, Nkeze J, Sen S, Jamindar S, Nasrin S, Sen S, Permala-Booth J, Sinclair J, Tapia MD, Johnson JK, Mamadou S, Thaden JT, Fowler VG Jr, Aguilar A, Terán E, Decre D, Morel F, Krogfelt KA, Brauner A, Protonotariou E, Christaki E, Shindo Y, Lin YT, Kwa AL, Shakoor S, Singh-Moodley A, Perovic O, Jacobs J, Lunguya O, Simon R, Cross AS, Tennant SM

    Frontiers in microbiology   Vol. 11   page: 1249   2020

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  45. BK virus-associated viruria and viremia in a patient with lymphangioleiomyomatosis after lung re-transplantation: A case report and review of the literature on BK virus infection post-lung transplantation

    Okumura Junya, Nakahara Yoshio, Nakaguro Masato, Shindo Yuichiro, Hase Tetsunari, Wakahara Keiko, Hashimoto Naozumi, Hasegawa Yoshinori

    JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 25 ( 10 ) page: 820 - 824   2019.10

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  46. Combination of aspirin plus macrolides in patients with severe community-acquired pneumonia: a hypothesis-generating study.

    Falcone M, Russo A, Shindo Y, Farcomeni A, Pieralli F, Cangemi R, Liu J, Xia J, Okumura J, Sano M, Jones C, Vannucchi V, Mancone M, Micek S, Xu F, Violi F, Kollef M

    Antimicrobial agents and chemotherapy   Vol. 63 ( 2 )   2019.2

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    DOI: 10.1128/AAC.01556-18

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    PubMed

  47. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of β-lactam plus macrolide combination therapy Reviewed

    Okumura J, Shindo Y, Takahashi K, Sano M, Sugino Y, Yagi T, Taniguchi H, Saka H, Matsui S, Hasegawa Y.

    Respirology   Vol. 23 ( 5 ) page: 526 - 534   2018.5

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    DOI: 10.1111/resp.13232

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  48. Validation of the prediction rules identifying drug-resistant pathogens in community-onset pneumonia

    Kobayashi Daisuke, Shindo Yuichiro, Ito Ryota, Iwaki Mai, Okumura Junya, Sakakibara Toshihiro, Yamaguchi Ikuo, Yagi Tetsuya, Ogasawara Tomohiko, Sugino Yasuteru, Taniguchi Hiroyuki, Saito Hiroshi, Saka Hideo, Kawamura Takashi, Hasegawa Yoshinori

    INFECTION AND DRUG RESISTANCE   Vol. 11   page: 1703 - 1713   2018

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    DOI: 10.2147/IDR.S165669

    Web of Science

    PubMed

  49. 院内肺炎、医療・介護関連肺炎の抗菌薬治療. Invited

    進藤有一郎、長谷川好規.

    Medical Practice   Vol. 35   page: 617 - 622   2018

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  50. 病棟管理栄養士のための臨床検査ファーストガイド―疾患別検査値の意味と読み方のポイント 肺炎. Invited

    進藤有一郎、田中文彦.

    臨床栄養   Vol. 133   page: 589 - 592   2018

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  51. Regional differences in antibiotic-resistant pathogens in patients with pneumonia: Implications for clinicians

    Shindo Yuichiro, Hasegawa Yoshinori

    RESPIROLOGY   Vol. 22 ( 8 ) page: 1536 - 1546   2017.11

  52. Anti-PD-L1 peptide improves survival in sepsis. Reviewed International coauthorship International journal

    Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, Hotchkiss RS

    The Journal of surgical research   Vol. 208   page: 33 - 39   2017.2

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    DOI: 10.1016/j.jss.2016.08.099

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    PubMed

  53. Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

    Shindo Y, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CD, Green JM, Morre M, Bochicchio GV, Hotchkiss RS

    Journal of leukocyte biology   Vol. 101 ( 2 ) page: 543 - 554   2017.2

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  54. Regional differences in antibiotic-resistant pathogens in patients with pneumonia: Implications for clinicians Invited Reviewed

    Shindo Y, Hasegawa Y

    Respirology   Vol. 22   page: 1536-1546   2017

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  55. 肺炎における薬剤耐性菌のリスクと抗菌治療. Invited

    進藤有一郎、長谷川好規.

    分子呼吸器病   Vol. 21   page: 52 - 55   2017

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  56. Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis. Reviewed International coauthorship International journal

    Amalakuhan B, Habib SA, Mangat M, Reyes LF, Rodriguez AH, Hinojosa CA, Soni NJ, Gilley RP, Bustamante CA, Anzueto A, Levine SM, Peters JI, Aliberti S, Sibila O, Chalmers JD, Torres A, Waterer GW, Martin-Loeches I, Bordon J, Blanquer J, Sanz F, Marcos PJ, Rello J, Ramirez J, Solé-Violán J, Luna CM, Feldman C, Witzenrath M, Wunderink RG, Stolz D, Wiemken TL, Shindo Y, Dela Cruz CS, Orihuela CJ, Restrepo MI

    Cytokine   Vol. 88   page: 267 - 273   2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cyto.2016.08.028

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  57. Multidrug-resistant pathogens in patients with pneumonia coming from the community. Invited Reviewed International coauthorship International journal

    Sibila O, Rodrigo-Troyano A, Shindo Y, Aliberti S, Restrepo MI

    Current opinion in pulmonary medicine   Vol. 22 ( 3 ) page: 219 - 26   2016.5

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    DOI: 10.1097/MCP.0000000000000263

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  58. Multidrug-resistant pathogens in patients with pneumonia coming from the community Invited Reviewed International coauthorship

    Sibila O, Rodrigo-Troyano A, Shindo Y, Aliberti S, and Restrepo MI

    Curr Opin Pulm Med   Vol. 22   page: 219-226   2016

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  59. Endothelial Adhesion Molecules and Multiple Organ Failure in Patients With Severe Sepsis Reviewed International coauthorship

    Amalakuhan B, Habib S, Mangat M, Reyes LF, Rodriguez AH, Hinojosa CA, Soni NJ, Gilley RP, Bustamante CA, Anzueto A, Levine SM, Peters JI, Aliberti S, Sibila O, Chalmers JD, Torres A, Waterer GW, Martin-Loeches I, Bordon J, Blanquer J, Sanz F, Marcos PJ, Rello J, Ramirez J, Solé-Violán J, Luna CM, Feldman C, Witzenrath M, Wunderink RG, Stolz D, Wiemken TL, Shindo Y, De La Cruz C, Orihuela1 CJ, and Restrepo MI

    Cytokine   Vol. 88   page: 267-273   2016

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  60. 肺炎の重症度と薬剤耐性菌のリスク因子の評価. Invited

    進藤有一郎、長谷川好規.

    化学療法の領域     2016

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  61. Pneumonia pathogen characterization is an independent determinant of hospital readmission Reviewed International coauthorship International journal

    Andruska A, Micek S, Shindo Y, Hampton N, Colona B, McCormick S, and Kollef M

    Chest   Vol. 148 ( 1 ) page: 103 - 111   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1378/chest.14-2129

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  62. Molecular Epidemiological Characteristics of Klebsiella pneumoniae Associated with Bacteremia among Patients with Pneumonia Reviewed International journal

    Ito R, Shindo Y, Kobayashi D, Ando M, Jin W, Wachino J, Yamada K, Kimura K, Yagi T, Hasegawa Y, and Arakawa Y

    J Clin Microbiol   Vol. 53 ( 3 ) page: 879 - 86   2015.3

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    DOI: 10.1128/JCM.03067-14

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  63. Prospective analysis of efficacy and safety of an individualized-midazolam-dosing protocol for sedation during prolonged bronchoscopy. Reviewed International journal

    Ogawa T, Imaizumi K, Hashimoto I, Shindo Y, Imai N, Uozu S, Shimokata T, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y

    Respiratory investigation   Vol. 52 ( 3 ) page: 153 - 9   2014.5

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    DOI: 10.1016/j.resinv.2013.09.003

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  64. Reply: isolation of drug-resistant pathogens does not always require use of broad-spectrum antibiotics in pneumonia. Reviewed International journal

    Shindo Y, Hasegawa Y

    American journal of respiratory and critical care medicine   Vol. 189 ( 6 ) page: 757 - 8   2014.3

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    DOI: 10.1164/rccm.201401-0029LE

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  65. Reply: HCAP not busy being born is busy dying. Reviewed International journal

    Shindo Y, Hasegawa Y

    American journal of respiratory and critical care medicine   Vol. 189 ( 3 ) page: 366 - 7   2014.2

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    DOI: 10.1164/rccm.201308-1550LE

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  66. Reply: HCAP Not Busy Being Born Is Busy Dying Reviewed

    Shindo Y and Hasegawa Y

    Am J Respir Crit Care Med   Vol. 189   page: 366-367   2014

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  67. Prospective analysis of efficacy and safety of an individualized-midazolam-dosing protocol for sedation during prolonged bronchoscopy Reviewed

    Ogawa T, Imaizumi K, Hashimoto I, Shindo Y, Imai N, Uozu S, Shimokata T, Ito S, Hashimoto N, Sato M, Kondo M, and Hasegawa Y

    Respir Investig   Vol. 52   page: 153-159   2014

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  68. Reply: Isolation of drug-resistant pathogens does not always require antibiotics of broad spectrum in pneumonia Reviewed

    Shindo Y and Hasegawa Y

    Am J Respir Crit Care Med   Vol. 189   page: 757-758   2014

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  69. Endobronchial ultrasound transbronchial needle aspiration in older people Reviewed International journal

    Okachi S, Imai N, Imaizumi K, Hase T, Shindo Y, Sakamoto K, Aso H, Wakahara K, Hashimoto I, Ito S, Hashimoto N, Sato M, Kondo M, and Hasegawa Y.

    Geriatr Gerontol Int   Vol. 13 ( 4 ) page: 986 - 92   2013.10

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    DOI: 10.1111/ggi.12043

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  70. Clinical practice guidelines for nursing- and healthcare-associated pneumonia (NHCAP) [complete translation]. Invited International journal

    Kohno S, Imamura Y, Shindo Y, Seki M, Ishida T, Teramoto S, Kadota J, Tomono K, Watanabe A

    Respiratory investigation   Vol. 51 ( 2 ) page: 103 - 26   2013.6

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    DOI: 10.1016/j.resinv.2012.11.001

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  71. Clinical practice guidelines for nursing- and healthcare-associated pneumonia (NHCAP)

    Kohno S, Imamura Y, Shindo Y, Seki M, Ishida T, Teramoto S, Kadota J, Tomono K, Watanabe A.

    Respir Invest   Vol. 51   page: 103-126   2013

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  72. 医療・介護関連肺炎の定義と病態 Invited

    進藤有一郎、長谷川好規

    月刊ナーシング   Vol. 32   page: 10-13   2012

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  73. NHCAPの原因菌と耐性菌の危険因子 Invited

    進藤有一郎、長谷川好規

    治療   Vol. 94   page: 39-42   2012

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  74. 新たな肺炎治療の考え方 「医療・介護関連肺炎(NHCAP)」とは―抗菌薬選択と患者ケアにおける注意点― Invited

    進藤有一郎、長谷川好規

    エキスパートナース   Vol. 28   page: 18-23   2012

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  75. Emerging Problems Regarding Severity Assessment and Treatment Strategies for Patients with Pneumonia: Controversies Surrounding the HCAP Concept Invited Reviewed International journal

    Shindo Y, Hasegawa Y

    Intern Emerg Med   Vol. 6 ( 5 ) page: 389 - 91   2011.10

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    DOI: 10.1007/s11739-011-0623-6

    PubMed

  76. Healthcare-associated pneumonia: diagnostic criteria and distinction from community-acquired pneumonia. Reviewed International coauthorship International journal

    Falcone M, Venditti M, Shindo Y, Kollef MH

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   Vol. 15 ( 8 ) page: e545 - 50   2011.8

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    DOI: 10.1016/j.ijid.2011.04.005

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  77. Clinical characteristics of Pneumocystis pneumonia in non-HIV patients and prognostic factors including microbiological genotypes. Reviewed International journal

    Matsumura Y, Shindo Y, Iinuma Y, Yamamoto M, Shirano M, Matsushima A, Nagao M, Ito Y, Takakura S, Hasegawa Y, Ichiyama S

    BMC infectious diseases   Vol. 11   page: 76   2011.3

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    DOI: 10.1186/1471-2334-11-76

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  78. 新たな肺炎の概念―「医療ケア関連肺炎」の臨床 Invited

    進藤有一郎、長谷川好規

    分子呼吸器病   Vol. 15   page: 58–65   2011

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  79. 新たな肺炎の概念―HCAPの位置付け治療戦略を探る―日本と米国の視点から-日本版ガイドライン(NHCAP)はどうあるべきか Invited

    河野茂、Marin H. Kollef、朝野和典、門田淳一、進藤有一郎

    化学療法の領域   Vol. 27   page: 126–135   2011

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  80. 呼吸器感染症ガイドラインの評価と今後の課題:医療ケア関連肺炎 Invited

    進藤有一郎、長谷川好規

    化学療法の領域   Vol. 27   page: 117–124   2011

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  81. 変貌する肺炎の臨床への対策 Invited

    河野茂、門田淳一、進藤有一郎、朝野和典

    呼吸   Vol. 30   page: 427–434   2011

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  82. NHCAPの実態 Invited

    進藤有一郎、長谷川好規

    メディカル朝日   Vol. 40   page: 18–19   2011

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  83. Clinical Characteristics and Genotypes of Pneumocystis Pneumonia in non-HIV Patients Reviewed

    Matsumura Y, Shindo Y, Iinuma Y, Yamamoto M, Shirano M, Matsushima A, Nagao M, Ito Y, Takakura S, Hasegawa Y, Ichiyama S

    BMC Infect Dis   Vol. 11   page: 76   2011

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  84. Healthcare-Associated Pneumonia: Diagnostic Criteria and Distinction from Community-Acquired Pneumonia Reviewed International coauthorship

    Falcone M, Venditti M, Shindo Y, Kollef MH

    Int J Infect Dis   Vol. 15   page: e545-550   2011

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  85. NHCAPの特徴は?:重症度と耐性菌のリスクについて Invited

    進藤有一郎、長谷川好規

    医薬ジャーナル   Vol. 47   page: 113-117   2011

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  86. Healthcare-Associated Pneumonia among Hospitalized Patients

    Shindo Yuichiro, Hasegawa Yoshinori

    APPLIED TECHNOLOGIES IN PULMONARY MEDICINE     page: 172 - 177   2011

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  87. Second-line weekly paclitaxel in resistant or relapsed non-small cell lung cancer treated with docetaxel and carboplatin: a multi-center phase II study. Reviewed International journal

    Ichikawa M, Suzuki R, Kataoka K, Noda Y, Shindoh J, Matsumoto S, Tanikawa Y, Suzuki K, Baba K, Shindo Y, Kondo M, Imaizumi K, Kume H, Hasegawa Y, Takagi K, Taniguchi H

    Lung cancer (Amsterdam, Netherlands)   Vol. 69 ( 3 ) page: 319 - 22   2010.9

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    DOI: 10.1016/j.lungcan.2009.11.021

    PubMed

  88. Second line weekly paclitaxel in resistant or relapsed non-small cell lung cancer treated with docetaxel and carboplatin: a multi-center phase II study Reviewed

    Ichikawa M, Suzuki R, Kataoka K, Noda Y, Shindoh J, Matsumoto S, Tanikawa Y, Suzuki K, Baba K, Shindo Y, Kondo M, Imaizumi K, Kume H, Hasegawa Y, Takagi K, Taniguchi H

    Lung Cancer   Vol. 69   page: 319-322   2010

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  89. 医療ケア関連肺炎(Healthcare-associated pneumonia: HCAP):新たな肺炎の概念 Invited

    進藤有一郎、長谷川好規

    呼吸器内科   Vol. 17   page: 62–70   2010

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  90. 医療ケア関連肺炎 (Healthcare-associated pneumonia: HCAP) はCAPやHAPとは対応が異なる Invited

    進藤有一郎、長谷川好規

    モダンフィジシャン   Vol. 30   page: 608–614   2010

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  91. 医療ケア関連肺炎(Health-Care-Associated Pneumonia: HCAP)の対応と治療戦略 Invited

    進藤有一郎

    Infection File   Vol. 29   page: 9   2010

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  92. 医療ケア関連肺炎(Health-care-associated pneumonia: HCAP):新たな肺炎の概念 Invited

    進藤有一郎、長谷川好規

    Geriatric Medicine   Vol. 10   page: 1307–1316   2010

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  93. 肺炎の分類 CAP(市中肺炎)、HCAP(医療ケア関連肺炎)、HAP(院内肺炎) Invited

    進藤有一郎、長谷川好規

    綜合臨床   Vol. 59   page: 2034–2040   2010

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  94. ユーザーメード肺炎データベースと基幹システムとの連携:診療支援・教育・多施設共同前向き研究ツールへの応用と課題

    進藤有一郎、長谷川好規、八木哲也、高橋正樹、吉田茂

    医療情報学   Vol. 30   page: S591–594   2010

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  95. Health-Care-Associated Pneumonia Is Primarily Due to Aspiration Pneumonia Response

    Shindo Yuichiro, Imaizumi Kazuyoshi, Hasegawa Yoshinori

    CHEST   Vol. 136 ( 6 ) page: 1703 - 1703   2009.12

  96. HCAPの病態, そして診断と治療-日本の現状を語る- Invited

    三鴨廣繁、栁原克紀、石田直、進藤有一郎

    Mebio   Vol. 26   page: 119–125   2009

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  97. Health-Care-Associated-Pneumonia(HCAP)の治療戦略について-欧米の現状と日本の今後-日本版ガイドライン作成に向けての提言 Invited

    河野茂、Lee E. Morrow、三鴨廣繁、石田直、関雅文、進藤有一郎

    化学療法の領域   Vol. 25   page: 108–121   2009

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  98. Health-care-associated pneumonia among hospitalized patients in a Japanese community hospital Reviewed

    Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Hashimoto N, Imaizumi K, Sato T, Hasegawa Y

    Chest   Vol. 135   page: 633-640   2009

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  99. Health-Care-Associated Pneumonia Is Primarily Due to Aspiration Pneumonia: Response Invited Reviewed

    Shindo Y, Imaizumi K, Hasegawa Y

    Chest   Vol. 136   page: 1703   2009

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  100. Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia. Reviewed International journal

    Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Imaizumi K, Hasegawa Y

    Respirology (Carlton, Vic.)   Vol. 13 ( 5 ) page: 731 - 5   2008.9

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    DOI: 10.1111/j.1440-1843.2008.01329.x

    PubMed

  101. Implication of clinical pathway care for community-acquired pneumonia in a community hospital: early switch from an intravenous beta-lactam plus a macrolide to an oral respiratory fluoroquinolone Reviewed

    Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Imaizumi K, Hasegawa Y

    Intern Med   Vol. 47   page: 1865-1874   2008

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  102. 院内肺炎の現状と今後の治療戦略 Invited

    渡辺彰、三鴨廣繁、寺本信嗣、関雅文、進藤有一郎

    Medical Tribune   Vol. 41   page: 78–81   2008

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    Language:Japanese  

  103. Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia Reviewed

    Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Imaizumi K, Hasegawa Y

    Respirology   Vol. 13   page: 731–735   2008

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  104. Implication of clinical pathway care for community-acquired pneumonia in a community hospital: early switch from an intravenous beta-lactam plus a macrolide to an oral respiratory fluoroquinolone. Reviewed International journal

    Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Imaizumi K, Hasegawa Y

    Internal medicine (Tokyo, Japan)   Vol. 47 ( 21 ) page: 1865 - 74   2008

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    DOI: 10.2169/internalmedicine.47.1343

    PubMed

  105. [Case of polymer fume fever with interstitial pneumonia caused by inhalation of polytetrafluoroethylene (Teflon)].

    Son M, Maruyama E, Shindo Y, Suganuma N, Sato S, Ogawa M

    Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology   Vol. 19 ( 3 ) page: 279 - 82   2006.7

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  106. [A case of Langerhans cell histiocytosis which resolved only on smoking cessation].

    Noma S, Nishiyama O, Iwaki M, Sakamoto K, Aso H, Shindo Y, Kato K, Kimura T, Kondoh Y, Taniguchi H

    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society   Vol. 44 ( 1 ) page: 43 - 7   2006.1

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  107. フッ素樹脂(テフロン)加工鍋の空焚きによりポリマーヒューム熱(PFF)と間質性肺炎をきたした1例 Reviewed

    孫政実, 丸山英一, 進藤有一郎, 菅沼伸一, 佐藤慎二, 小川雅弘

    中毒研究   Vol. 19   page: 279–282   2006

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  108. 禁煙にて軽快を示した肋骨原発Langerhans cell histiocytosisの1例 Reviewed

    野間聖, 西山理, 岩木舞, 阪本考司, 麻生裕紀, 進藤有一郎, 加藤景介, 木村智樹, 近藤康博, 谷口博之

    日本呼吸器学会雑誌   Vol. 44   page: 43–47   2006

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  109. Covered expandable metalic Stent placement for hemostasis of colonic bleeding caused by invasion of gallbladder carcinoma Reviewed

    Hasegawa N, Kato K, Morita K, Kuroiwa M, Shinkai M, Hayashi T, Kamioka T, Otagiri H, Shindo Y, Goto H

    Endoscopy   Vol. 35   page: 178–180   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

  110. 気道内にポリープを呈した子宮肉腫肺転移の1例 Reviewed

    矢野誠, 谷口博之, 近藤康博, 木村智樹, 西山理, 清水淳一, 長谷川隆一, 進藤有一郎, 阪本考司

    気管支学   Vol. 25   page: 482–483   2003

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  111. 超低体温循環停止下両側肺動脈血せん内膜摘除術が著効したOver-Systemic肺高血圧を呈する慢性肺動脈血せん塞せん症の1例

    江田匡仁, 進藤有一郎, 矢野隆, 市原利彦, 上田裕一, 安藤太三

    呼吸と循環   Vol. 51   page: 401–406   2003

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

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Books 18

  1. Macrolide therapy for patients with pneumonia: a triple-edged sword. In: Aliberti S, Chalmers JD, Pletz M, eds. Anti-infectives and the Lung (ERS Monograph)

    Shindo Y, Hasegawa Y( Role: Joint author)

    European Respiratory Society  2017 

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    Language:English Book type:Scholarly book

  2. Health-Care-Associated Pneumonia among Hospitalized Patients. In: Esquinas A, ed. Applied Technologies in Pulmonary Medicine

    Shindo Y, Hasegawa Y( Role: Joint author)

    Karger Medical and Scientific Publishers  2011  ( ISBN:978-3-8055-9585-8

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    Language:English

  3. 臨床試験の事典

    大北宗由、西田一貴、錦見満曉、進藤有一郎、丹後俊郎、松井茂之( Role: Contributor ,  第13章 疾患領域別の臨床試験 83. 感染症領域)

    朝倉書店  2023.1  ( ISBN:978-4-254-32264-4

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    Total pages:592   Responsible for pages:246-249   Language:Japanese Book type:Textbook, survey, introduction

  4. 感染症 最新の治療2022-2024

    進藤有一郎( Role: Joint author ,  Ⅲ 主な臓器別感染症 E. 呼吸器感染症 4. 院内肺炎)

    南江堂  2022.2  ( ISBN:978-4-524-22997-0

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    Total pages:336   Responsible for pages:125-129   Language:Japanese Book type:Scholarly book

  5. 別冊 日本臨床 領域別症候群シリーズ No. 19 呼吸器症候群 (第3版)(Ⅳ) ―その他の呼吸器疾患を含めて―

    進藤有一郎( Role: Joint author ,  Ⅸ. 呼吸器感染症 9. 感染症関連病態 (8) 市中肺炎と院内肺炎)

    日本臨床社  2021.11 

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    Responsible for pages:336-341   Language:Japanese Book type:Scholarly book

  6. 呼吸器病レジデントマニュアル (第6版)

    進藤有一郎( Role: Joint author ,  第3章 主な呼吸器疾患の診断と治療 A. 肺感染症 2. 市中肺炎)

    医学書院  2021.4  ( ISBN:978-4-260-04592-6

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    Total pages:520   Responsible for pages:196-204   Language:Japanese Book type:Scholarly book

  7. 新 呼吸器専門医テキスト 改訂第2版. 各論Ⅰ 気道・肺疾患 E. 肺膿瘍

    進藤有一郎.( Role: Joint author)

    南江堂  2020 

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    Responsible for pages:324-326   Language:Japanese Book type:Scholarly book

  8. Advances in Aging and Health Research 2017. 高齢者の感染症とその対策. 第3章 各論1 高齢者の各種感染症 高齢者の肺炎.

    進藤有一郎、長谷川好規.( Role: Joint author)

    公益財団法人 長寿科学振興財団  2018 

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    Responsible for pages:41-49   Language:Japanese

  9. 呼吸器疾患診断治療アプローチ 呼吸器感染症 第4章 特殊病態下(免疫抑制患者)の呼吸器感染症 医療・介護に関連した呼吸器感染症

    進藤有一郎, 長谷川好規( Role: Joint author)

    中山書店  2017 

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    Language:Japanese Book type:Scholarly book

  10. 新 呼吸器専門医テキスト. 各論Ⅰ 気道・肺疾患 E. 肺化膿症.

    進藤有一郎.( Role: Joint author)

    南江堂  2017 

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    Responsible for pages:283-284   Language:Japanese Book type:Scholarly book

  11. 新 呼吸器専門医テキスト. 各論Ⅰ 気道・肺疾患 E. 肺化膿症

    進藤有一郎( Role: Sole author)

    南江堂  2015 

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    Language:Japanese Book type:Scholarly book

  12. 呼吸器病レジデントマニュアル (第5版). 第3章 主な呼吸器疾患の診断と治療 A. 肺感染症 2. 市中肺炎

    進藤有一郎( Role: Sole author)

    医学書院  2015 

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    Language:Japanese Book type:Scholarly book

  13. 別冊「医学のあゆみ」 呼吸器疾患 state of arts Ver.6 第4章 主要疾患―病態・診断・治療 15. 医療・介護関連肺炎(NHCAP)

    進藤有一郎、長谷川好規( Role: Joint author)

    医歯薬出版株式会社  2013 

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    Language:Japanese

  14. 呼吸器疾患 最新の治療 2013―2015 第XV章 呼吸器疾患の患者指導 4.誤嚥性肺炎防止のための患者指導

    進藤有一郎、長谷川好規( Role: Joint author)

    南江堂  2013 

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    Language:Japanese

  15. 抗菌薬の選択と使い方 呼吸器内科領域

    進藤有一郎、長谷川好規( Role: Joint author)

    医薬ジャーナル社  2012 

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    Language:Japanese

  16. ガイドラインサポートハンドブック 呼吸器感染症 第IV章 欧米ガイドラインとの比較 3.クライテリア

    進藤有一郎, 長谷川好規, 他( Role: Joint author)

    医薬ジャーナル社  2011.6  ( ISBN:978-4-7532-2499-9

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    Language:Japanese

  17. 肺炎ガイドライン活用のための抗菌薬のかしこい使い方 第I章B 肺炎ガイドラインを使いこなすポイント 8.中等症例での抗菌薬の使い方のコツは?

    進藤有一郎, 長谷川好規, 他( Role: Joint author)

    南江堂  2009.10  ( ISBN:978-4-524-26012-6

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    Language:Japanese

  18. 最新抗菌薬療法マニュアル 第II章 疾患各論 4.医療ケア関連肺炎;何を選んでどう使うか?

    進藤有一郎, 長谷川好規, 他( Role: Joint author)

    新興医学出版社  2009.9  ( ISBN:978-4-88002-688-6

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    Language:Japanese

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Presentations 50

  1. Epidemiology of Community-Acquired Pneumonia during the COVID-19 Pandemic in Japan Invited International conference

    Shindo Y

    The 2023 International Respiratory Infections Society Research Forum  2023.5.21  International Respiratory Infections Society

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    Event date: 2023.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Washington, D.C.   Country:United States  

  2. Epidemiological characteristics and therapeutic challenges in COVID-19 in Japan Invited International conference

    Shindo Y

    The 25th Congress of the Asian Pacific Society of Respirology  2021.11  Asian Pacific Society of Respirology

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    Event date: 2021.11

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Kyoto   Country:Japan  

  3. The role of lymphocytopenia in patients with nosocomial pneumonia & future directions of research on host immunity and adjunctive therapy for severe pneumonia. Invited International conference

    Shindo Y.

    The International Respiratory Infections 2019 Conference  2019.5  The International Respiratory Infection Society

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    Event date: 2019.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Dallas   Country:United States  

  4. Immunotherapeutic strategies for sepsis and pneumonia Invited International conference

    Shindo Y

    The International Respiratory Infections Conference 2017 

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    Event date: 2017.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Washington, D.C., USA   Country:United States  

  5. An extra-pulmonary etiology of non-resolving pneumonia Invited International conference

    Shindo Y

    European Respiratory Society International Congress 2016 

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:London, UK   Country:United Kingdom  

  6. Risk Factors for 30-Day Mortality in Patients with Pneumonia Who Receive Appropriate Initial Antibiotics: Who are the Candidates for Adjunctive Therapy? Invited International conference

    Shindo Y

    CAPO Research Symposium 2015 

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    Event date: 2015.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  7. 冬本番にあたってのCOVID-19、インフルエンザを含めた急性気道感染症診療ストラテジーを考える Invited

    進藤有一郎

    日本呼吸器学会COVID-19配信特別シンポジウム  2022.12.29  日本呼吸器学会

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン   Country:Japan  

  8. 新たな成人肺炎診療ガイドライン Invited

    進藤有一郎

    第70回日本化学療法学会総会  2022.6.5  日本化学療法学会

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    Event date: 2022.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:岐阜   Country:Japan  

  9. COVID-19診療における現場の疑問点を考察する ―呼吸器学会FAQ広場に寄せられた質問とexpert opinionワーキンググループによる回答を中心に―.第7波にどのように対応するか ~第6波までの経験を踏まえて~ Invited

    進藤有一郎

    第62回日本呼吸器学会学術講演会  2022.4  日本呼吸器学会

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    Event date: 2022.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:京都   Country:Japan  

  10. Japanese, multicenter, phase II trial of combination therapy with favipiravir and methylprednisolone for COVID-19 patients with non-critical respiratory failure: The J-CRITICAL trial International conference

    Shindo Y, Kondoh Y, Kada A, Doi Y, Tomii K, Mukae H, Murata N, Imai R, Okamoto M, Yamano Y, Miyazaki Y, Shinoda M, Aso H, Izumi S, Ishii H, Ito R, Saito AM, Saito TI, Hasegawa Y

    The 25th Congress of the Asian Pacific Society of Respirology  2021.11  Asian Pacific Society of Respirology

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    Event date: 2021.11

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto   Country:Japan  

  11. COVID-19診療における現場の疑問点を考察する ―呼吸器学会FAQ広場に寄せられた質問を中心に― 抗ウイルス剤 Invited

    進藤有一郎

    第61回日本呼吸器学会学術講演会  2021.4.23  日本呼吸器学会

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    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京  

  12. Common diseaseを適切に管理するには―限られた資源の有効活用― Invited

    進藤有一郎

    第60回日本呼吸器学会学術講演会  2020.9  日本呼吸器学会

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:神戸   Country:Japan  

  13. 透析患者における感染症の特徴と対策 呼吸器感染症の実態と対策 Invited

    進藤有一郎

    第94回日本感染症学会総会  2020.8  日本感染症学会

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    Event date: 2020.8

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京   Country:Japan  

  14. 生物学的製剤と呼吸器感染症 細菌性肺炎 Invited

    進藤有一郎

    第94回日本感染症学会総会  2020.8  日本感染症学会

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    Event date: 2020.8

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京   Country:Japan  

  15. Bacteremic pneumococcal pneumonia is associated with an increased rate of cardiovascular events International coauthorship International conference

    Borsa N, Ruiz Iturriaga L, Fernandez L, España P, Aliberti S, Ramírez J, Sibila O, Rodrigo A, Rodriguez A, Sanz F, Shindo Y, Martin-Loeches I, Luna C, Stoltz D, Viasus D, Carratalá J, Anzueto A, and Restrepo M

    European Respiratory Society International Congress 2019  2019.9  European Respiratory Society

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    Event date: 2019.9

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Spain  

  16. A New Scoring System for Predicting Adverse Events in Hospitalized Patients with Community-Onset Pneumonia

    Sakakibara T., Shindo Y., Takahashi K., Kobayashi D., Okumura J., Sano M., Murakami Y., Thabet N., Kobayashi H., Yagi T., Matsui S., Saka H., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE  2019.5  American Thoracic Society

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    Event date: 2019.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Dallas   Country:United States  

  17. Severe and Prolonged Lymphopenia Are Associated with Poor Outcome in Patients with Postoperative Pneumonia

    Murakami Y., Shindo Y., Sano M., Okumura J., Sakakibara T., Kobayashi H., Thabet N., Yagi T., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE  2019.5  American Thoracic Society

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    Event date: 2019.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Dallas   Country:United States  

  18. Risk factors for drug-resistant pathogens in patients with hospital-acquired and ventilator-associated pneumonia International conference

    Sano M, Shindo Y, Okumura J, Sakakibara T, Matsuda T, Yagi T, and Hasegawa Y

    European Respiratory Society International Congress 2017  2017.9  European Respiratory Society

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Milan   Country:Italy  

  19. Risk Factors for Severe Adverse Outcomes in Patients with Hospital-Acquired Pneumonia International conference

    Sano M, Shindo Y, Okumura J, Sakakibara T, Matsuda T, Yagi T, Matsui K, Takahashi K, Matsui S, Hasegawa Y

    American Thoracic Society 2017 International Conference 

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    Event date: 2017.5

    Language:English   Presentation type:Poster presentation  

    Venue:Washington, D.C., USA   Country:United States  

  20. Risk Factors For Severe Adverse Outcomes In Patients With Hospital-Acquired Pneumonia International conference

    Sano M., Shindo Y., Okumura J., Sakakibara T., Matsuda T., Yagi T., Matsui K., Takahashi K., Matsui S., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE  2017.5  American Thoracic Society

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    Event date: 2017.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Washington, D.C.   Country:United States  

  21. Implication of β-lactam plus macrolide combination therapy on mortality in patients with community-onset pneumonia at low risk for drug-resistant pathogens. International conference

    Okumura J, Shindo Y, Sano M, Sakakibara T, Matsuda T, Takahashi K, Saka H, Matsui S, and Hasegawa Y.

    Asian Pacific Society of Respirology 2017 Congress  2017  Asian Pacific Society of Respirology

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    Event date: 2017

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Sydney   Country:Australia  

  22. Interleukin 7 immunotherapy improves survival in sepsis followed by secondary Pseudomonas aeruginosa pneumonia International coauthorship International conference

    Shindo Y, Fuchs AG, Davis CG, Unsinger J, Eitas T, Burnham C, Green JM, Bochicchio GV, Hotchkiss RS

    American Thoracic Society 2016 International Conference 

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    Event date: 2016.5

    Language:English   Presentation type:Poster presentation  

    Venue:San Francisco   Country:Japan  

  23. 大規模臨床研究結果からみえてくる肺炎診療の課題と治療戦略への提言 Invited

    進藤有一郎

    第56回日本呼吸器学会学術講演会 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:京都   Country:Japan  

  24. Mortality Risks in Patients with Pneumonia Who Received Appropriate Initial Antibiotics International conference

    Shindo Y, Kobayashi D, Ito R, Ando M, Ichikawa M, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, and Hasegawa Y

    American Thoracic Society 

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    Event date: 2014.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  25. Risk Factors of Resistant Pathogens for Beta-lactam plus Macrolide, or Fluoroquinolone in Hospitalized Patients with CAP and HCAP: A Multicenter Prospective Observational Study among Patients with CAP, HCAP, and HAP in Japan (CJLSG 0911) International conference

    Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Yagi T, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, and Hasegawa Y

    CHEST 2012  2012.10 

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    Event date: 2012.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  26. What do physicians need for the guidelines for Nursing and Health-Care-Associated Pneumonia? Invited

    Yuichiro Shindo

    The 86th Annual Meeting of the Japanese Association for Infectious Diseases 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  27. Coordination of a user-made database of pneumonia and EMR: A potentially useful tool for medical support, education, and multicenter prospective study

    Yuichiro Shindo, Daisuke Kobayashi, Ryota Ito, Yoshinori Hasegawa, Mitsutaka Iguchi, Yuka Tomita, Testuya Yagi, Masaki Takahashi, Shigeru Yoshida

    The 86th Annual Meeting of the Japanese Association for Infectious Diseases 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  28. Future Perspectives on the Guidelines for Patients with Community-Acquired Pneumonia: A Proposals for the Revisions

    Yuichiro Shindo

    The 52nd Annual Meeting of the Japanese Respiratory Society 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  29. Evidence of Patients with Health-Care-Associated Pneumonia in Japan: Controversies Surrounding the HCAP Concept International conference

    Yuichiro Shindo

    The 52nd Annual Meeting of the Japanese Respiratory Society 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  30. Guidelines for Nursing and Health-Care-Associated Pneumonia in Japan: Controversies Surrounding the NHCAP Concept International conference

    Yuichiro Shindo

    The 52nd Annual Meeting of the Japanese Respiratory Society 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  31. Prospective Analysis of Efficacy and Safety of Individualized Administration of Midazolam for Sedation During Bronchoscopy International conference

    2. Imaizumi K, Hashimoto I, Shindo Y, Imai N, Ogawa T, Morise M, Ito S, Hashimoto N, Sato M, Kondo M, and Hasegawa Y

    CHEST 2011 

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    Event date: 2011.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  32. 肺炎治療に必要な新概念「医療・介護関連肺炎」~「誤嚥」患者に対する一味違った抗菌薬の選び方~

    進藤有一郎

    第52回日本神経学会総会 

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    Event date: 2011.5

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:名古屋   Country:Japan  

  33. 日本のNHCAPの実態(2)~新たな肺炎カテゴリーの現状と今後の課題~

    進藤有一郎

    第51回日本呼吸器学会学術講演会 

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    Event date: 2011.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京   Country:Japan  

  34. ユーザーメード肺炎データベースと基幹システムとの連携:診療支援・教育・多施設共同前向き研究ツールへの応用と課題

    進藤有一郎、長谷川好規、八木哲也、高橋正樹、吉田茂

    第30回医療情報学連合大会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松   Country:Japan  

  35. 医療ケア関連肺炎の診断と治療 ~新たな肺炎の治療概念~

    進藤有一郎.

    第52回日本老年医学会学術集会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:神戸   Country:Japan  

  36. 医療ケア関連肺炎の現状と今後の課題

    進藤有一郎

    第58回日本化学療法学会総会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:長崎   Country:Japan  

  37. 本邦におけるHCAPの実態-CAP, HAPガイドラインによる分類からの検証-

    進藤有一郎

    第58回日本化学療法学会総会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:長崎   Country:Japan  

  38. 呼吸器内科専門医育成に望むこと―若手医師の立場から―

    進藤有一郎

    第50回日本呼吸器学会学術講演会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:京都   Country:Japan  

  39. 医療ケア関連肺炎の診断と治療-新たな肺炎の概念-

    進藤有一郎

    第25回日本環境感染学会総会 

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    Event date: 2010.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  40. Clinical and Molecular Characteristics of Pneumocystis Pneumonia in 52 Non-HIV-Infected Patients in 2 Japanese University Hospitals International conference

    Matsumura Y, Shindo Y, Shirano M, Matsushima A, Nagao M, Ito Y, Takakura S, Iinuma Y, Ichiyama S

    47th Annual Meeting of IDSA  2009.10 

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    Event date: 2009.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  41. 医療ケア関連肺炎(HCAP)とJRS院内肺炎ガイドライン:HCAPの治療戦略の在り方はどうあるべきか?

    進藤有一郎、佐藤慎二、丸山英一、大橋能理、小川雅弘、伊藤理、橋本直純、佐藤光夫、近藤征史、今泉和良、長谷川好規

    第49回日本呼吸器学会学術講演会 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  42. Healthcare-associated pneumonia among hospitalized patients in a Japanese community hospital International conference

    Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Hashimoto N, Imaizumi K, Sato T, Hasegawa Y

    ATS 2009 International Conference 

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    Event date: 2009.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  43. 市中病院におけるHealth care-associated pneumonia (HCAP): 市中肺炎(CAP)との比較研究

    進藤有一郎、佐藤慎二、丸山英一、大橋能理、小川雅弘、伊藤理、近藤征史、橋本直純、今泉和良、佐藤俊哉、長谷川好規

    第48回日本呼吸器学会学術講演会 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  44. 市中病院におけるHealth care-associated pneumonia (HCAP): 市中肺炎(CAP)との比較研究

    進藤有一郎、佐藤慎二、丸山英一、大橋能理、小川雅弘、伊藤理、近藤征史、橋本直純、今泉和良、佐藤俊哉、長谷川好規

    第82回日本感染症学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:松江   Country:Japan  

  45. 当院での市中肺炎入院症例の検討~スウィッチ療法を含んだクリニカル・パス使用効果について~

    進藤有一郎、佐藤慎二、丸山英一、大橋能理、小川雅弘

    第47回日本呼吸器学会学術講演会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  46. TSガイドライン(2001年)による市中肺炎入院症例の検討

    進藤有一郎, 谷口博之, 近藤康博, 木村智樹, 西山理, 清水淳市

    第44回日本呼吸器学会学術講演会 

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    Event date: 2006.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  47. 当院における在宅NPPV療法施行症例の検討

    進藤有一郎, 谷口博之, 近藤康博, 西山理, 清水淳市, 矢野誠, 阪本考司, 麻生裕紀, 長谷川隆一

    第25回日本呼吸管理学会学術集会 

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    Event date: 2003.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:幕張   Country:Japan  

  48. 喘息急性増悪に対するmontelukastの追加効果に関する検討

    進藤有一郎, 谷口博之, 近藤康博, 西山理

    第15回日本アレルギー学会春季臨床大会 

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    Event date: 2003.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  49. 頻回に血球貪食症候群を呈した成人発症スティル病の一例

    進藤有一郎, 石川英昭, 中村智信, 北川渡, 林宏樹, 稲熊大城, 近藤康博, 若尾孝明, 公文進一

    第46回日本リウマチ学会総会 

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    Event date: 2002.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  50. 術前over systemicを呈した慢性血栓塞栓性肺高血圧症に対する肺動脈血栓内膜摘除術〜術後管理を中心に〜

    進藤有一郎, 市原利彦, 川瀬正樹, 上田裕一

    第29回日本集中治療医学会総会 

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    Event date: 2002.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:岡山   Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. 軽度呼吸不全を呈するCOVID-19肺炎患者に対するファビピラビル/ステロイド併用療法の多施設共同第II相試験

    Grant number:20fk0108256h0001  2020.7 - 2021.3

    日本医療研究開発機構(AMED) 

  2. 重症呼吸器感染症の免疫動態解明とIL-7を含めた新規免疫療法ストラテジーの構築

    Grant number:20K08517  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    進藤 有一郎

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    研究代表者の先行研究で国際的に初めて明らかにした適切な抗菌治療を受けた肺炎患者における死亡リスク因子は自然・獲得免疫機能低下との関連が報告されており、免疫賦活療法の適応となる患者の存在が示唆される。しかし、免疫賦活療法として具体的に何を?いつ?使えばよいかについては答えが現在ない。
    本研究は、主に重症肺炎患者検体を用いて予後良好/不良群の免疫状態とその経時的変化の違いを明らかにすることで、IL-7を基軸とした免疫賦活療法の投与対象候補者と投与タイミングを探索するとともに、確立してきた動物モデルを用いて有効性の機序をより明確化し将来の臨床試験への基盤をつくることを目的として行われる。
    重症肺炎患者を主たる対象として血液サンプルを採取し免疫応答解析を進めている。先行研究(Shindo, et al. Lancet infect Dis 2015)から得た知見をもとに、入院時に臨床パラメータから死亡低リスク群、死亡高リスク群に分類し、その後それぞれの群の患者の血液を血漿と血球に分け、血漿は主にサイトカイン測定のためのELISA、血球はマルチカラーフローサイトメトリーによる解析を進めている。約10名の患者検体を用いたプレリミナリーな検討では、死亡低リスク群に比べて、死亡高リスク群の患者では、リンパ球数が少ない傾向にあった。リンパ球系に主眼を置いて解析しているが、死亡高リスク群の患者ではCD8+ T細胞では活性化マーカーのCD127+細胞の割合が低下傾向にあり、CD4+ T細胞ではPD-1の発現割合が高かった。また、死亡高リスク群の患者のCD4+ T細胞では死亡低リスク群に比べてIFN-gの産生増強があるものの、IL-2産生能は減弱していた。これらの結果から死亡高リスク群患者から得られるT細胞疲弊からくる機能低下が示唆された。
    次年度は肺炎患者をCOVID-19、non-COVID-19群に分けての比較検討も行い新規免疫療法治療ストラテジー構築に向けた解析を行う予定である。すでに患者検体収集は進めており、経時的にサンプリングを行うことで、免疫応答がどのように変化していくか、とくにT細胞表面の共抑制分子の発現や、サイトカイン産生をはじめとする機能の変化に着目する。またCOVID-19では制御性T細胞の低下遷延による免疫応答の調節が破綻していることも示唆されるため、T細胞の分化能、制御性T細胞機能解析も進める。
    ・免疫応答解析を進めるマルチカラーフローサイトメトリーなどの実験方法は確立している。
    ・倫理審査でも承認は得られており、患者からの検体収集はすでに開始している。
    ・市中発症の重症肺炎、外科術後肺炎における好中球のプロファイルが異なり治療ターゲットになり得る可能性があるため、その病態解明に向けた実験も進めている。
    ・COVID-19、non-COVID-19群に分けての比較検討ができる準備も整えている。
    ・患者サンプルを使用した研究:
    我々の過去の研究結果(Shindo, et al. Lancet Infect Dis 2015)に基づいて、適切な抗菌治療を行っても死亡リスクが高い患者群を研究にエントリーし、これらの患者のサンプルを用い、リンパ球、好中球を中心とした免疫細胞の細胞死の状態評価、細胞増殖、サイトカイン分泌能などの機能解析をマルチカラーフローサイトメトリー法を用いて行い、さらにCyTOFを用いた解析も行い免疫応答の詳細な解析を行う。また血漿中の炎症性、抗炎症性サイトカイン分泌に関するELISAを用いた解析を継続して行う。
    COVID-19、non-COVID-19群に分けての比較検討を行い、この2群での免疫応答の違いを解明することで、よりよい肺炎免疫治療戦略を構築することを目的に研究を進める方針である。

  3. Development of novel immunotherapy including IL-7 for severe respiratory tract infections

    Grant number:17K09610  2017.4 - 2020.3

    Shindo Yuichiro

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    We developed a two-hit mouse model of sepsis and secondary Pseudomonas pneumonia. The results showed that IL-7 administration after sepsis onset improved the survival of the two-hit model (JLB 2017). Anti-PD-L1 peptide was also effective for improving the survival of septic mouse model (JSR 2017).
    In patients with severe community-acquired pneumonia and those with post-operative pneumonia, we reported that time courses of absolute counts of lymphocytes and neutrophils were different between survivors and non-survivors in both pneumonia groups (ATS 2019). From these results, we made presentations on the perspectives on possible immunotherapeutic strategies in patients with severe respiratory tract infections (IRIC 2017, IRIC 2019).

  4. Cross-talk between the kidneys and the lungs

    Grant number:15K09282  2015.4 - 2018.3

    Yuzawa Yukio

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    Authorship:Coinvestigator(s) 

    Organ crosstalk is known to occur in the presence of kidney injury, with the injury spreading to distal organs, including the heart. However, little knowledge exists on the crosstalk linking the kidneys and lungs. Thus, we aimed to clarify the kidney-lung crosstalk by conducting a prospective observational study on the onset and prognosis of acute kidney injury (AKI) in a cohort of patients hospitalized for pneumonia. A new severity score that takes AKI into account would allow for an easy and accurate estimation of the mortality risk during treatment of pneumonia, which causes more than 110,000 deaths in Japan per year, accounting for the third highest number of deaths after malignant neoplasms and heart disease. This study does not only verify the crosstalk between the kidneys and the lungs but also recommends the importance of future medical treatment based on organ crosstalk rather than being constrained to treatment for single organs.

 

Teaching Experience (On-campus) 6

  1. 基盤医学特論

    2012

  2. 臨床実習 ポリクリⅠ

    2012

  3. 胸部レントゲン写真の読影

    2012

  4. 呼吸器感染症1

    2012

  5. 胸部レントゲン写真の読影

    2011

  6. 臨床実習 ポリクリⅠ

    2011

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