Updated on 2021/04/07

写真a

 
BABA, Yoshinobu
 
Organization
Institutes of Innovation for Future Society Professor
Institute for Advanced Research
Institutes of Innovation for Future Society
Institutes of Innovation for Future Society Director in General
Title
Professor

Degree 1

  1. Dr. Sci. ( Kyushu University ) 

Research Interests 5

  1. analytical chemistry

  2. personalized medicine

  3. genome

  4. biotechnology

  5. nanotechnology

Research Areas 4

  1. Nanotechnology/Materials / Nano/micro-systems  / Micro/Nanodevice

  2. Nanotechnology/Materials / Nanobioscience  / Nano Materials/Nano Bioscience

  3. Life Science / Genome biology  / Applied Genome Science

  4. Nanotechnology/Materials / Analytical chemistry  / Analytical Chemistry

Current Research Project and SDGs 6

  1. いきいき百歳社会実現

  2. 次世代ナノバイオデバイスの創成とゲノム医療への応用に関する研究

  3. ナノバイオデバイス、AI、量子生命科学による次世代ヘルスケア開拓

  4. ナノ空間における生体分子・細胞の構造・機能解析に関する研究

  5. システムバイオロジーを目指した計測技術開発に関する研究

  6. 1分子DNA解析と1分子DNAマニピュレーションに関する研究

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Research History 42

  1. 量子科学技術研究開発機構   量子生命・医学部門 量子生命科学研究所   所長(センター長)

    2021.4

  2. 量子科学技術研究開発機構   量子生命科学研究拠点センター   所長(センター長)

    2021.2

  3. ONCOLille, フランスLille がん学際領域研究所   国際科学諮問委員会   特別招へい教授

    2020.12

  4. Nagoya University   Institute of Innovation for Future Society   Professor

    2020.7

  5. 新エネルギー・産業技術総合開発機構(NEDO)   技術戦略研究センター(TSC) フェロー   フェロー

    2020.4

  6. 量子科学技術研究開発機構   量子生命科学領域   所長(センター長)

    2019.4 - 2021.3

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    Country:Japan

  7. Nagoya University   Professor

    2019.1

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    Country:Japan

  8. Nagoya University   Institute of Innovation for Future Society   Director in General

    2018.10

  9. JST   CREST 「細胞外微粒子に起因する生命現象の解明とその制御に向けた基盤技術の創出」   所長(センター長)

    2017.4

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    Country:Japan

  10. The University of Tokyo   Professor

    2017.4 - 2019.3

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    Country:Japan

  11. 高雄医科大学   薬学部   特別招へい教授

    2017.2

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    Country:Japan

  12. Nagoya University   Director in General

    2015.4 - 2019.3

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    Country:Japan

  13. Nagoya University   Re-organized Schools and Institutes / Centers Nano Device Research Center   Director in General

    2015.4 - 2019.3

  14. 名古屋大学 未来社会創造機構 教授

    2014.4

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    Country:Japan

  15. Nagoya University   Professor

    2014.4

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    Country:Japan

  16. Nagoya University   Institute of Innovation for Future Society

    2014.4

  17. 名古屋大学シンクロトロン光研究センター センター長

    2012.4 - 2015.3

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    Country:Japan

  18. Nagoya University   Synchrotron Radiation Research Center   Director in General

    2012.4 - 2015.3

  19. 名古屋大学シンクロトロン光研究センター 副センター長

    2011.8 - 2012.3

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    Country:Japan

  20. Nagoya University   Synchrotron Radiation Research Center

    2011.8 - 2012.3

  21. Nagoya University   FIRST Research Center for Innovative Nanobiodevice   Director in General

    2010.12 - 2015.3

  22. 名古屋大学 総長補佐(産学官連携担当・研究推進担当)

    2010.4 - 2012.3

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    Country:Japan

  23. 産業技術総合研究所 健康工学研究部門 研究顧問 併任

    2010.4

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    Country:Japan

  24. 名古屋大学革新ナノバイオデバイス研究センター センター長(併任)

    2010.3 - 2015.3

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    Country:Japan

  25. Nagoya University

    2008.4

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    Country:Japan

  26. Nagoya University

    2008.4 - 2012.3

  27. 名古屋大学 総長補佐(研究推進担当)

    2008.4 - 2010.3

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    Country:Japan

  28. 自然科学研究機構・分子科学研究所・客員教授

    2007.4 - 2009.3

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    Country:Japan

  29. Nagoya University

    2006.10

  30. Professor, Plasma Nanotechnology Research Center, Nagoya University

    2006.10

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    Country:Japan

  31. Nagoya University   Innovative Research Center for Preventive Medical Engineering

    2006.8

  32. Professor, MEXT Innovative Research Center for Preventive Medical Engineering, Nagoya University

    2006.8

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    Country:Japan

  33. 産業技術総合研究所 健康工学研究センター 副センター長 併任

    2005.4 - 2010.3

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    Country:Japan

  34. 名古屋大学大学院工学研究科 教授

    2004.10

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    Country:Japan

  35. 産業技術総合研究所 単一分子生体ナノ計測研究ラボ ラボ長 併任

    2002.10 - 2005.3

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    Country:Japan

  36. 徳島大学薬学部 教授

    1997.4 - 2005.3

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    Country:Japan

  37. 神戸薬科大学薬学部 助教授

    1996.4 - 1997.3

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    Country:Japan

  38. 神戸女子薬科大学薬学部 講師

    1990.4 - 1996.3

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    Country:Japan

  39. 大分大学教育学部 講師

    1988.4 - 1990.3

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    Country:Japan

  40. 大分大学教育学部 助手

    1986.6 - 1988.3

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    Country:Japan

  41. 日本学術振興会 特別研究員

    1986.4 - 1986.5

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    Country:Japan

  42. 量子科学技術研究開発機構   量子生命科学研究拠点センター   所長(センター長)

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Education 3

  1. Kyushu University   Graduate School, Division of Natural Science   Department of Chemistry

    1983.4 - 1986.3

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    Country: Japan

  2. Kyushu University   Graduate School, Division of Natural Science

    1981.4 - 1983.3

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    Country: Japan

  3. Kyushu University   Faculty of Science   Department of Chemistry

    1977.4 - 1981.3

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    Country: Japan

Professional Memberships 20

  1. 日本化学会   生命化学研究会会長

    2002.4 - 2005.3

  2. 化学とマイクロ・ナノシステム研究会   会長

    2006.4 - 2009.3

  3. アメリカ化学会   Anal. Chem.副編集長

  4. 王立化学協会   フェロー, Lab on Chip編集委員、Nanoscale編集委員

    2005.4

  5. アメリカ科学振興協会

  6. アメリカ応用物理学会   Biomicrofluidics編集委員

  7. 国際ナノメディシンアカデミー   理事

  8. アジアパシフィックナノメディシンアカデミー   会長

  9. 電気学会   バイオ極限分析調査専門委員会委員長

    2006.4 - 2009.3

  10. Amarican Academy of Nanomedicine   Fellow

    2006.4 - 2007.3

  11. 日本化学会   生命化学研究会幹事

    2004.4

  12. 日本薬学会   薬学研究ビジョン部会会長

    2004.4 - 2007.3

  13. 日本分析化学会

    1984.4

  14. 日本分子生物学会

  15. 日本電気泳動学会

  16. 日本バイオマテリアル学会   評議員

  17. 近畿化学協会

  18. 日本希土類学会

  19. 化学センサ研究会

  20. クロマトグラフィー科学会

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Awards 17

  1. 日本化学会 学会賞

    2021.3   ナノバイオデバイスによるバイオ計測化学・バイオ医工学の革新

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    Award type:International academic award (Japan or overseas)  Country:Japan

  2. 化学とマイクロ・ナノシステム学会 学会賞

    2021.3  

  3. 寺部茂賞

    2016.11   ナノバイオデバイスの創製と生体分析への展開

    馬場嘉信

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  4. 文部科学大臣表彰 科学技術賞 研究部門

    2016.4  

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    Country:Japan

  5. 日本分析化学会 学会賞

    2015.9  

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    Country:Japan

  6. クロマトグラフィー科学会 学会賞

    2014.12  

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    Country:Japan

  7. モノづくり連携大賞特別賞

    2009.11  

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    Country:Japan

  8. 日本化学会学術賞

    2008.3  

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    Country:Japan

  9. フェロー アメリカナノメディシンアカデミー

    2006  

  10. 第28回応用物理学会論文賞

    2006  

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    Country:Japan

  11. フェロー 英国王立化学会

    2005  

  12. 2004年度メルク賞

    2004  

  13. 平成16年度日本トキシコロジー学会賞(田邊賞)

    2004  

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    Country:Japan

  14. 平成15年度竹田国際貢

    2003  

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    Country:Japan

  15. 第38回徳島新聞賞科学賞

    2002  

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    Country:Japan

  16. 平成9年度日本薬学会奨励賞

    1997  

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    Country:Japan

  17. 平成3年度日本薬学会近畿支部奨励賞

    1992  

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    Country:Japan

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Papers 1117

  1. Urinary MicroRNA-Based Diagnostic Model for Central Nervous System Tumors Using Nanowire Scaffolds. International journal

    Yotaro Kitano, Kosuke Aoki, Fumiharu Ohka, Shintaro Yamazaki, Kazuya Motomura, Kuniaki Tanahashi, Masaki Hirano, Tsuyoshi Naganawa, Mikiko Iida, Yukihiro Shiraki, Tomohide Nishikawa, Hiroyuki Shimizu, Junya Yamaguchi, Sachi Maeda, Hidenori Suzuki, Toshihiko Wakabayashi, Yoshinobu Baba, Takao Yasui, Atsushi Natsume

    ACS applied materials & interfaces     2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    There are no accurate mass screening methods for early detection of central nervous system (CNS) tumors. Recently, liquid biopsy has received a lot of attention for less-invasive cancer screening. Unlike other cancers, CNS tumors require efforts to find biomarkers due to the blood-brain barrier, which restricts molecular exchange between the parenchyma and blood. Additionally, because a satisfactory way to collect urinary biomarkers is lacking, urine-based liquid biopsy has not been fully investigated despite the fact that it has some advantages compared to blood or cerebrospinal fluid-based biopsy. Here, we have developed a mass-producible and sterilizable nanowire-based device that can extract urinary microRNAs efficiently. Urinary microRNAs from patients with CNS tumors (n = 119) and noncancer individuals (n = 100) were analyzed using a microarray to yield comprehensive microRNA expression profiles. To clarify the origin of urinary microRNAs of patients with CNS tumors, glioblastoma organoids were generated. Glioblastoma organoid-derived differentially expressed microRNAs (DEMs) included 73.4% of the DEMs in urine of patients with parental tumors but included only 3.9% of those in urine of noncancer individuals, which suggested that many CNS tumor-derived microRNAs could be identified in urine directly. We constructed the diagnostic model based on the expression of the selected microRNAs and found that it was able to differentiate patients and noncancer individuals at a sensitivity and specificity of 100 and 97%, respectively, in an independent dataset. Our findings demonstrate that urinary microRNAs extracted with the nanowire device offer a well-fitted strategy for mass screening of CNS tumors.

    DOI: 10.1021/acsami.1c01754

    PubMed

  2. Rational Strategy for Space-Confined Seeded Growth of ZnO Nanowires in Meter-Long Microtubes. International journal

    Ryoma Kamei, Takuro Hosomi, Eisuke Kanao, Masaki Kanai, Kazuki Nagashima, Tsunaki Takahashi, Guozhu Zhang, Takao Yasui, Jun Terao, Koji Otsuka, Yoshinobu Baba, Takuya Kubo, Takeshi Yanagida

    ACS applied materials & interfaces     2021.3

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    Seeded crystal growths of nanostructures within confined spaces offer an interesting approach to design chemical reaction spaces with tailored inner surface properties. However, such crystal growth within confined spaces tends to be inherently difficult as the length increases as a result of confinement effects. Here, we demonstrate a space-confined seeded growth of ZnO nanowires within meter-long microtubes of 100 μm inner diameter with the aspect ratio of up to 10 000, which had been unattainable to previous methods of seeded crystal growths. ZnO nanowires could be grown via seeded hydrothermal crystal growth for relatively short microtubes below the length of 40 mm, while any ZnO nanostructures were not observable at all for longer microtubes above 60 mm with the aspect ratio of 600. Microstructural and mass spectrometric analysis revealed that a conventional seed layer formation using zinc acetate is unfeasible within the confined space of long microtubes as a result of the formation of detrimental residual Zn complex compounds. To overcome this space-confined issue, a flow-assisted seed layer formation is proposed. This flow-assisted method enables growth of spatially uniform ZnO nanowires via removing residual compounds even for 1 m long microtubes with the aspect ratio of up to 10 000. Finally, the applicably of ZnO-nanowire-decorated long microtubes for liquid-phase separations was demonstrated.

    DOI: 10.1021/acsami.0c22709

    PubMed

  3. Microheater-integrated zinc oxide nanowire microfluidic device for hybridization-based detection of target single-stranded DNA. International journal

    Hiromi Takahashi, Takao Yasui, Hiromu Kashida, Koki Makino, Keiko Shinjo, Quanli Liu, Taisuke Shimada, Sakon Rahong, Noritada Kaji, Hiroyuki Asanuma, Yoshinobu Baba

    Nanotechnology     2021.3

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    Detection of cell-free DNA (cfDNA) has an impact on DNA analysis in liquid biopsies. However, current strategies to detect cfDNA have limitations that should be overcome, such as having low sensitivity, and requiring much time and a specialized instrument. Thus, non-invasive and rapid detection tools are needed for disease prevention and early-stage treatment. Here we developed a device having a microheater integrated with zinc oxide nanowires (microheater-ZnO-NWs) to detect target single-stranded DNAs (ssDNAs) based on DNA probe hybridization. We confirmed experimentally that our device realized in-situ annealed DNA probes by which we subsequently detected target ssDNAs. We envision that this device can be utilized for fundamental studies related to nanobiodevice-based DNA detection.

    DOI: 10.1088/1361-6528/abef2c

    PubMed

  4. A thermally robust and strongly oxidizing surface of WO<inf>3</inf>hydrate nanowires for electrical aldehyde sensing with long-term stability

    Zhang G.

    Journal of Materials Chemistry A   Vol. 9 ( 9 ) page: 5815 - 5824   2021.3

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    Publishing type:Research paper (scientific journal)   Publisher:Journal of Materials Chemistry A  

    DOI: 10.1039/d0ta11287a

    Scopus

  5. Wide-field fluorescent nanodiamond spin measurements toward real-time large-area intracellular thermometry. International journal

    Yushi Nishimura, Keisuke Oshimi, Yumi Umehara, Yuka Kumon, Kazu Miyaji, Hiroshi Yukawa, Yutaka Shikano, Tsutomu Matsubara, Masazumi Fujiwara, Yoshinobu Baba, Yoshio Teki

    Scientific reports   Vol. 11 ( 1 ) page: 4248 - 4248   2021.2

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    Measuring optically detected magnetic resonance (ODMR) of diamond nitrogen vacancy centers significantly depends on the photon detectors used. We study camera-based wide-field ODMR measurements to examine the performance in thermometry by comparing the results to those of the confocal-based ODMR detection. We show that the temperature sensitivity of the camera-based measurements can be as high as that of the confocal detection and that possible artifacts of the ODMR shift are produced owing to the complexity of the camera-based measurements. Although measurements from wide-field ODMR of nanodiamonds in living cells can provide temperature precisions consistent with those of confocal detection, the technique requires the integration of rapid ODMR measurement protocols for better precisions. Our results can aid the development of camera-based real-time large-area spin-based thermometry of living cells.

    DOI: 10.1038/s41598-021-83285-y

    Scopus

    PubMed

  6. Microfluidic-based capture and release of cancer-derived exosomes via peptide-nanowire hybrid interface. International journal

    Thanawat Suwatthanarak, Ivan Adiyasa Thiodorus, Masayoshi Tanaka, Taisuke Shimada, Daiki Takeshita, Takao Yasui, Yoshinobu Baba, Mina Okochi

    Lab on a chip   Vol. 21 ( 3 ) page: 597 - 607   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    Cancer-derived circulating exosomes or nanoscale extracellular vesicles are emerging biomarkers for disease detection and treatment because of their cell-specific constituents and unique intercellular pathways. For efficient exosome isolation from bio-fluids, the design of high-affinity nanointerfaces is of great importance in the development of miniaturized systems for the collection of exosomes. Herein, we report peptide-functionalized nanowires as a biorecognition interface for the capture and release of cancer-derived exosomes within a microfluidic channel. Based on the amino-acid sequence of EWI-2 protein, a partial peptide that bound to the CD9 exosome marker and thus targeted cancer exosomes was screened. Linkage of the exosome-targeting peptide with a ZnO-binding sequence allowed one-step and reagent-free peptide modification of the ZnO nanowire array. As a result of peptide functionalization, the exosome-capturing ability of ZnO nanowires was significantly improved. Furthermore, the captured exosomes could be subsequently released from the nanowires under a neutral salt condition for downstream applications. This engineered surface that enhances the nanowires' efficiency in selective and controllable collection of cancer-derived exosomes provides an alternative foundation for developing microfluidic platforms for exosome-based diagnostics and therapeutics.

    DOI: 10.1039/d0lc00899k

    Web of Science

    Scopus

    PubMed

  7. Determination of three antiepileptic drugs in pharmaceutical formulations using microfluidic chips coupled with light-emitting diode induced fluorescence detection. Reviewed International journal

    Abdallah M Zeid, Jenny Jeehan M Nasr, Fathalla Belal, Mohamed I Walash, Yoshinobu Baba, Noritada Kaji

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy   Vol. 246   page: 119021 - 119021   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    In this study, a facile, sensitive, and precise lab-on-a-chip electrophoretic method coupled with light-emitting diode induced fluorescence (LED-IF) detection was developed to assay three antiepileptic drugs, namely, vigabatrin, pregabalin, and gabapentin, in pharmaceutical formulations. The analytes were derivatised offline for the first time with fluorescine-5-isothiocyanate (FITC) to yield highly fluorescent derivatives with λex/em of 490/520nm. The FITC-labelled analytes were injected, separated, and quantitated by a microfluidic electrophoresis device using fluorescence detection. The labelled analytes were monitored using a blue LED-IF system. The separation conditions were significantly optimised adding specific concentrations of heptakis-(2,6-di-O-methyl)-β-cyclodextrin (HDM-β-CD) and methylcellulose to the buffer solution (40mM borate buffer). HDM-β-CD acted as a selective host for the studied antiepileptic drugs, rendering a high separation efficiency. Methylcellulose was used as an efficient dynamic coating polymer to prevent the labelled drugs from being adsorbed on the inner surfaces of the poly (methylmethacrylate) microchannels. A laboratory-prepared ternary mixture of the three antiepileptic drugs was separated within 100s with acceptable resolution between all the three analytes (Rs>3) and a high number of theoretical plates (N) for each analyte (N≈106 plates/m). The sensitivity of the method was enhanced approximately 80-fold by stacking to yield a detection limit below 0.6ngmL-1 in the concentration range of 2.0-200.0ngmL-1. The method was successfully validated for analysing the studied drugs in their pharmaceutical formulations.

    DOI: 10.1016/j.saa.2020.119021

    Web of Science

    Scopus

    PubMed

  8. ZnO/SiO2 core/shell nanowires for capturing CpG rich single-stranded DNAs. International journal

    Marina Musa, Takao Yasui, Kazuki Nagashima, Masafumi Horiuchi, Zetao Zhu, Quanli Liu, Taisuke Shimada, Akihide Arima, Takeshi Yanagida, Yoshinobu Baba

    Analytical methods : advancing methods and applications   Vol. 13 ( 3 ) page: 337 - 344   2021.1

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    Atomic layer deposition (ALD) is capable of providing an ultrathin layer on high-aspect ratio structures with good conformality and tunable film properties. In this research, we modified the surface of ZnO nanowires through ALD for the fabrication of a ZnO/SiO2 (core/shell) nanowire microfluidic device which we utilized for the capture of CpG-rich single-stranded DNAs (ssDNA). Structural changes of the nanowires while varying the number of ALD cycles were evaluated by statistical analysis and their relationship with the capture efficiency was investigated. We hypothesized that finding the optimum number of ALD cycles would be crucial to ensure adequate coating for successful tuning to the desired surface properties, besides promoting a sufficient trapping region with optimal spacing size for capturing the ssDNAs as the biomolecules traverse through the dispersed nanowires. Using the optimal condition, we achieved high capture efficiency of ssDNAs (86.7%) which showed good potential to be further extended for the analysis of CpG sites in cancer-related genes. This finding is beneficial to the future design of core/shell nanowires for capturing ssDNAs in biomedical applications.

    DOI: 10.1039/d0ay02138e

    Scopus

    PubMed

  9. Oxide Nanowire Microfluidic Devices for Capturing Single-stranded DNAs.

    Marina Musa, Takao Yasui, Zetao Zhu, Kazuki Nagashima, Miki Ono, Quanli Liu, Hiromi Takahashi, Taisuke Shimada, Akihide Arima, Takeshi Yanagida, Yoshinobu Baba

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry     2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2116/analsci.20P421

    PubMed

    CiNii Article

  10. Solid-State Nanopore Platform Integrated with Machine Learning for Digital Diagnosis of Virus Infection. International journal

    Akihide Arima, Makusu Tsutsui, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

    Analytical chemistry   Vol. 93 ( 1 ) page: 215 - 227   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.analchem.0c04353

    Web of Science

    Scopus

    PubMed

  11. Microfluidic fast chiral separation of baclofen and phenylalanine enantiomers based on cyclodextrin-electrokinetic chromatography International journal

    Abdallah M. Zeid, Jenny Jeehan M. Nasr, Fathalla Belal, Mohamed Walash, Noritada Kaji, Yoshinobu Baba

    Microchemical Journal   Vol. 160   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    © 2020 Elsevier B.V. A green chiral lab-on-a-chip cyclodextrin-based microchip electrophoretic method was developed for enantioseparation of baclofen (BCN) and phenylalanine (Phe) enantiomers for the first time. All BCN and Phe enantiomers were offline labeled with 4-fluoro-7-nitrobenzofurazan (NBD-F) or fluorescein-5-isothiocyanate (FITC) fluorogenic reagents prior to microfluidic injection in a dynamically coated polymethylmethacrylate microchip. The enantioseparation was performed using borate buffer solution (50 mM; pH 9.5) containing a dynamic coating polymer (methylcellulose) and a chiral selector of cyclodextrin (CD) family as the background electrolyte. The combination of sieving properties of methylcellulose polymer and inclusion complex formation properties of the cyclodextrins rendered a novel green pseudo-stationary phase for the microfluidic chiral separation of the studied enantiomers in short separation time. Seven CD chiral selectors were investigated in our study to illustrate the proposed enantioseparation mechanism in the dynamically coated microfluidic channels. The results indicated that use of a modified cyclodextrin, heptakis-(2,6-di-O-methyl)-β-cyclodextrin (HDM-β-CD), resulted in extra interactions with the analytes of interest, leading to extra resolution with high number of theoretical plates. Therefore, HDM-β-CD was able to separate the NBD-labeled and FITC-labeled enantiomers of BCN and Phe within short analytical time. Sensitivity problem of microchip electrophoresis was overcome by application of field-enhanced injection stacking which improved sensitivity to a higher extent by online preconcentration of the labeled enantiomers in the microfluidic channels. The method was fully validated and successfully applied for the assay of BCN enantiomers and Phe enantiomers in their pure racemic mixtures. Moreover, the developed method was applied for precise analysis of BCN enantiomers in pharmaceutical formulations and in biological samples. The extraction recovery values of BCN enantiomers in biological samples were > 87.5% and %RSD < 7.0.

    DOI: 10.1016/j.microc.2020.105770

    Web of Science

    Scopus

  12. ナノデバイスを用いた細胞外小胞・エクソソームの分離精製 Invited Reviewed

    安井隆雄、馬場嘉信

    化学工学   Vol. 85   2021

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  13. 尿中マイクロRNA測定技術 Invited Reviewed

    安井隆雄、馬場嘉信

    ぶんせき   Vol. 6   page: 204 - 207   2021

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  14. Nanobiodevices for the isolation of circulating nucleic acid for biomedical applications Invited Reviewed

    H. Takahashi, T. Yasui, Y. Baba

    Chem Lett.     2021

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    DOI: doi.org/10.1246/cl.210066

  15. これからの化学を考える 2100年の分析化学 Invited Reviewed

    馬場嘉信

    現代化学創刊50周年記念号   Vol. 3   page: 41 - 43   2021

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  16. Digital Pathology Platform for Respiratory Tract Infection Diagnosis via Multiplex Single-Particle Detections. Reviewed International journal

    Akihide Arima, Makusu Tsutsui, Takeshi Yoshida, Kenji Tatematsu, Tomoko Yamazaki, Kazumichi Yokota, Shun'ichi Kuroda, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

    ACS sensors   Vol. 5 ( 11 ) page: 3398 - 3403   2020.11

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    The variability of bioparticles remains a key barrier to realizing the competent potential of nanoscale detection into a digital diagnosis of an extraneous object that causes an infectious disease. Here, we report label-free virus identification based on machine-learning classification. Single virus particles were detected using nanopores, and resistive-pulse waveforms were analyzed multilaterally using artificial intelligence. In the discrimination, over 99% accuracy for five different virus species was demonstrated. This advance is accessed through the classification of virus-derived ionic current signal patterns reflecting their intrinsic physical properties in a high-dimensional feature space. Moreover, consideration of viral similarity based on the accuracies indicates the contributing factors in the recognitions. The present findings offer the prospect of a novel surveillance system applicable to detection of multiple viruses including new strains.

    DOI: 10.1021/acssensors.0c01564

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  17. Highlighting Microfluidic Research to Coincide with the Virtual MicroTAS 2020 Meeting. Reviewed International journal

    Yoshinobu Baba

    Analytical chemistry   Vol. 92 ( 20 ) page: 13613 - 13613   2020.10

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    DOI: 10.1021/acs.analchem.0c03959

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  18. Silica Nanopillar Arrays for Monitoring Diffraction-Based Label-Free Biomolecule Separation International journal

    Taiga Ajiri, Takao Yasui, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Junji Nishii, Yoshinobu Baba, Manabu Tokeshi

    ACS Applied Nano Materials   Vol. 3 ( 9 ) page: 8810 - 8816   2020.9

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    Copyright © 2020 American Chemical Society. Recent studies on nanopillar arrays, one type of nanofluidic device, have demonstrated various tools for bioanalysis. When carrying out nanopillar array-based separation, it is indispensable to observe biomolecules, such as DNA, proteins, and extracellular vesicles, that have fluorescence labeling; however, fluorescence labeling influences the biomolecular characteristics. Here, we have proposed label-free monitoring of biomolecule separation by using diffracted light derived from the nanopillar array that was fabricated inside a microchannel by combining laser interference lithography with general photolithography techniques. Using an electrophoresis approach, we demonstrated that our diffraction-based label-free method possessed high sensor initialization ability, and the nanopillar array device successfully monitored DNA separation without labeling bias. Results obtained using our label-free monitoring of DNA separation confirmed, for the first time, that the molecular dynamics of DNA molecules in the nanopillar array were changed in the presence or absence of fluorescent labeling. The presented concept will provide a useful tool for nonbiased monitoring of label-free biomolecule analysis in nanofluidic channels.

    DOI: 10.1021/acsanm.0c01600

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  19. Ammonia-Induced Seed Layer Transformations in a Hydrothermal Growth Process of Zinc Oxide Nanowires International journal

    Quanli Liu, Takao Yasui, Kazuki Nagashima, Takeshi Yanagida, Mitsuo Hara, Masafumi Horiuchi, Zetao Zhu, Hiromi Takahashi, Taisuke Shimada, Akihide Arima, Yoshinobu Baba

    Journal of Physical Chemistry C   Vol. 124 ( 37 ) page: 20563 - 20568   2020.9

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    Copyright © 2020 American Chemical Society. Ammonia is a well-known additive to promote crystal growth in hydrothermal synthesis of ZnO nanowires. Although the effect of ammonia on the nanowire growth has been intensively investigated, its influence on the seed layer, which governs the initial nanowire growth, is rarely discussed. Here, we demonstrate that ammonia strongly affects the seed layer as well as the following nanowire growth. On increasing the ammonia concentration, the nanowire density first increases and then decreases, while the nanowire growth rate keeps increasing. Experimental results and thermodynamic calculations of the initial growth process reveal that the transformation of the seed layer induced by ammonia prior to nucleation critically determines the nanowire density and thus also influences the following nanowire growth. Present results highlight the critical importance of discussing the variation of seed layers in ammonia-involved hydrothermal synthesis and suggest a novel seed engineering approach for tailoring the ZnO nanowire growth.

    DOI: 10.1021/acs.jpcc.0c05490

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  20. Clinical and Prognostic Values of ALBI Score in Patients With Acute Heart Failure

    Matsue Y.

    Heart Lung and Circulation   Vol. 29 ( 9 ) page: 1328 - 1337   2020.9

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    DOI: 10.1016/j.hlc.2019.12.003

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  21. Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO2 Nanowire Structures Formed by Bottom-Up Approaches. Reviewed International journal

    Taisuke Shimada, Takao Yasui, Akihiro Yonese, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

    Micromachines   Vol. 11 ( 6 )   2020.6

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    There are growing interests in mechanical rupture-based antibacterial surfaces with nanostructures that have little toxicity to cells around the surfaces; however, current surfaces are fabricated via top-down nanotechnologies, which presents difficulties to apply for bio-surfaces with hierarchal three-dimensional structures. Herein, we developed ZnO/SiO2 nanowire structures by using bottom-up approaches and demonstrated to show mechanical rupture-based antibacterial activity and compatibility with human cells. When Escherichia coli were cultured on the surface for 24 h, over 99% of the bacteria were inactivated, while more than 80% of HeLa cells that were cultured on the surface for 24 h were still alive. This is the first demonstration of mechanical rupture-based bacterial rupture via the hydrothermally synthesized nanowire structures with antibacterial activity and cell compatibility.

    DOI: 10.3390/mi11060610

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  22. Developing spray-freeze-dried particles containing a hyaluronic acid-coated liposome-protamine-DNA complex for pulmonary inhalation.

    Fukushige K, Tagami T, Naito M, Goto E, Hirai S, Hatayama N, Yokota H, Yasui T, Baba Y, Ozeki T

    International journal of pharmaceutics   Vol. 583   page: 119338   2020.6

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    DOI: 10.1016/j.ijpharm.2020.119338

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  23. Observation of ethanol-induced condensation and decondensation processes at a single DNA molecular level in microfluidic devices equipped with a rapid solution exchange system. Reviewed

    Suzuki H, Fujiyoshi K, Kaji N, Tokeshi M, Baba Y

    Analytical chemistry   Vol. 92 ( 13 ) page: 9132 - 9137   2020.6

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    DOI: 10.1021/acs.analchem.0c01417

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  24. Visualization of Human Induced Pluripotent Stem Cells-Derived Three-Dimensional Cartilage Tissue by Gelatin Nanospheres.

    Murata Y, Jo JI, Yukawa H, Tsumaki N, Baba Y, Tabata Y

    Tissue engineering. Part C, Methods   Vol. 26 ( 5 ) page: 244-252   2020.5

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    DOI: 10.1089/ten.TEC.2020.0029

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  25. A quantum thermometric sensing and analysis system using fluorescent nanodiamonds for the evaluation of living stem cell functions according to intracellular temperature Reviewed International journal

    Hiroshi Yukawa, Masazumi Fujiwara, Kaori Kobayashi, Yuka Kumon, Kazu Miyaji, Yushi Nishimura, Keisuke Oshimi, Yumi Umehara, Yoshio Teki, Takayuki Iwasaki, Mutsuko Hatano, Hideki Hashimoto, Yoshinobu Baba

    Nanoscale Advances   Vol. 2 ( 5 ) page: 1859 - 1868   2020.5

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    © The Royal Society of Chemistry 2020. Intracellular thermometry techniques play an important role in elucidating the relationship between the intracellular temperature and stem cell functions. However, there have been few reports on thermometry techniques that can detect the intracellular temperature of cells during several days of incubation. In this study, we developed a novel quantum thermometric sensing and analysis system (QTAS) using fluorescent nanodiamonds (FNDs). FNDs could label adipose tissue-derived stem cells (ASCs) at high efficiency with 24 h of incubation, and no cytotoxicity was observed in ASCs labeled with less than 500 μg mL−1of FNDs. The peak of FNDs was confirmed at approximately 2.87 GHz with the characteristic fluorescence spectra of NV centers that could be optically detected (optically detected magnetic resonance [ODMR]). The ODMR peak clearly shifted to the high-frequency side as the temperature decreased and gave a mean temperature dependence of −(77.6 ± 11.0) kHz °C−1, thus the intracellular temperature of living ASCs during several days of culturing could be precisely measured using the QTAS. Moreover, the intracellular temperature was found to influence the production of growth factors and the degree of differentiation into adipocytes and osteocytes. These data suggest that the QTAS can be used to investigate the relationship between intracellular temperature and cellular functions.

    DOI: 10.1039/d0na00146e

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  26. Monovalent sulfur oxoanions enable millimeter-long single-crystalline h-WO<sub>3</sub> nanowire synthesis. Reviewed

    Zhang G, Wang C, Mizukami W, Hosomi T, Nagashima K, Yoshida H, Nakamura K, Takahashi T, Kanai M, Yasui T, Aoki Y, Baba Y, Yanagida T

    Nanoscale   Vol. 12 ( 16 ) page: 9058-9066   2020.4

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    DOI: 10.1039/c9nr10565d

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  27. Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin. Reviewed

    Nishinaga Y, Sato K, Yasui H, Taki S, Takahashi K, Shimizu M, Endo R, Koike C, Kuramoto N, Nakamura S, Fukui T, Yukawa H, Baba Y, K Kaneko M, Chen-Yoshikawa TF, Kobayashi H, Kato Y, Hasegawa Y

    Cells   Vol. 9 ( 4 )   2020.4

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    DOI: 10.3390/cells9041019

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  28. Photolithographically Constructed Single ZnO Nanowire Device and Its Ultraviolet Photoresponse.

    Liu Q, Yasui T, Nagashima K, Yanagida T, Horiuchi M, Zhu Z, Takahashi H, Shimada T, Arima A, Baba Y

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry     2020.4

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    DOI: 10.2116/analsci.20N002

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  29. Tailored Photoluminescence Properties of Ag(In,Ga)Se<inf>2</inf> Quantum Dots for Near-Infrared in Vivo Imaging Reviewed International journal

    Tatsuya Kameyama, Hiroki Yamauchi, Takahisa Yamamoto, Toshiki Mizumaki, Hiroshi Yukawa, Masahiro Yamamoto, Shigeru Ikeda, Taro Uematsu, Yoshinobu Baba, Susumu Kuwabata, Tsukasa Torimoto

    ACS Applied Nano Materials   Vol. 3 ( 4 ) page: 3275 - 3287   2020.4

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    Copyright © 2020 American Chemical Society. Multinary semiconductor quantum dots (QDs) that have less toxicity and show near-infrared light responsivity have attracted much attention for in vivo bioimaging. In this study, we controlled the optical properties of Ag-In-Se QDs by modulating the nonstoichiometry and the degree of Ga3+ doping. Precise tuning of the Ag/In ratio of Ag-In-Se QDs enabled a sharp band-edge emission to emerge without broad defect-site emission. Ga3+ doping into Ag-In-Se (AIGSe) QDs enlarged their energy gap, resulting in a blue shift of the band-edge PL peak from from 890 to 630 nm. The band-edge PL intensity was remarkably enlarged by surface coating with a thin GaSx shell followed by treatment with trioctylphosphine, the highest PL yield being 38% for the PL peak at 800 nm. Thus-obtained QDs were successfully used as near-IR PL probes for three-dimensional in vivo bioimaging in which the wavelengths of excitation and detection lights could be selected in the first biological window, and then the signals were clearly detected from AIGSe@GaSx core-shell QDs injected into biological tissues by ca. 5 mm in depth.

    DOI: 10.1021/acsanm.9b02608

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  30. A Method to Analyze Urinary Extracellular Vesicles. Reviewed

    Paisrisarn P, Yasui T, Baba Y

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 36 ( 7 ) page: 791 - 798   2020.3

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    DOI: 10.2116/analsci.20R001

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  31. Mechanical Low-Pass Filtering of Cells for Detection of Circulating Tumor Cells in Whole Blood Reviewed

    Suzuki Taiki, Kaji Noritada, Yasaki Hirotoshi, Yasui Takao, Baba Yoshinobu

    ANALYTICAL CHEMISTRY   Vol. 92 ( 3 ) page: 2483 - 2491   2020.2

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    DOI: 10.1021/acs.analchem.9b03939

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  32. Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer. Reviewed International journal

    Yoshitaka Isobe, Kazuhide Sato, Yuko Nishinaga, Kazuomi Takahashi, Shunichi Taki, Hirotoshi Yasui, Misae Shimizu, Rena Endo, Chiaki Koike, Noriko Kuramoto, Hiroshi Yukawa, Shota Nakamura, Takayuki Fukui, Koji Kawaguchi, Toyofumi F Chen-Yoshikawa, Yoshinobu Baba, Yoshinori Hasegawa

    EBioMedicine   Vol. 52   page: 102632 - 102632   2020.2

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    BACKGROUND: Small cell lung cancer (SCLC) has a poor prognosis, and its treatment options are limited. Delta-like protein 3 (DLL3) is expressed specifically in SCLC and is considered a promising therapeutic target for patients with this disease. Rovalpituzumab tesirine (Rova-T) was the first antibody-drug conjugate targeting DLL3. Although Rova-T development was unfortunately terminated, DLL3 remains an ideal target for SCLC. Near infrared photoimmunotherapy (NIR-PIT) is a new form of cancer treatment that employs an antibody-photosensitiser conjugate followed by NIR light exposure and damage target cells specifically. In this study, we demonstrate DLL3-targeted NIR-PIT to develop a novel molecularly targeted treatment for SCLC. METHODS: The anti-DLL3 monoclonal antibody rovalpituzumab was conjugated to an IR700 photosensitiser (termed 'rova-IR700'). SCLC cells overexpressing DLL3 as well as non-DLL3-expressing controls were incubated with rova-IR700 and then exposed to NIR-light. Next, mice with SCLC xenografts were injected with rova-IR700 and irradiated with NIR-light. FINDINGS: DLL3-overexpressing cells underwent immediate destruction upon NIR-light exposure, whereas the control cells remained intact. The xenograft in mice treated with rova-IR700 and NIR-light shrank markedly, whereas neither rova-IR700 injection nor NIR-light irradiation alone affected tumour size. INTERPRETATION: Our data suggest that targeting of DLL3 using NIR-PIT could be a novel and promising treatment for SCLC. FUNDING: Research supported by grants from the Program for Developing Next-generation Researchers (Japan Science and Technology Agency), KAKEN (18K15923, JSPS), Medical Research Encouragement Prize of The Japan Medical Association, The Nitto Foundation, Kanae Foundation for the Promotion of Medical Science.

    DOI: 10.1016/j.ebiom.2020.102632

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  33. A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats Reviewed

    Kitase Yuma, Sato Yoshiaki, Ueda Kazuto, Suzuki Toshihiko, Mikrogeorgiou Alkisti, Sugiyama Yuichiro, Matsubara Kohki, Okabe Yuka Tsukagoshi, Shimizu Shinobu, Hirata Hitoshi, Yukawa Hiroshi, Baba Yoshinobu, Tsuji Masahiro, Takahashi Yoshiyuki, Yamamoto Akihito, Hayakawa Masahiro

    STEM CELLS AND DEVELOPMENT   Vol. 29 ( 2 ) page: 63 - 74   2020.1

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    DOI: 10.1089/scd.2019.0221

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  34. Synthesis of Monodispersedly Sized ZnO Nanowires from Randomly Sized Seeds Reviewed

    Zhao Xixi, Nagashima Kazuki, Zhang Guozhu, Hosomi Takuro, Yoshida Hideto, Akihiro Yuya, Kanai Masaki, Mizukami Wataru, Zhu Zetao, Takahashi Tsunaki, Suzuki Masaru, Samransuksamer Benjarong, Meng Gang, Yasui Takao, Aoki Yuriko, Baba Yoshinobu, Yanagida Takeshi

    NANO LETTERS   Vol. 20 ( 1 ) page: 599 - 605   2020.1

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    DOI: 10.1021/acs.nanolett.9b04367

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  35. Temperature sensing of stem cells using fluorescent nanodiamonds for an evaluation of the regenerative functions

    Miyaji Kazu, Kobayashi Kaori, Nishimura Yushi, Fujiwara Masazumi, Yukawa Hiroshi, Baba Yoshinobu

    Organ Biology   Vol. 27 ( 2 ) page: 185 - 190   2020

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    <p>It has become clear that temperature plays a major role in many life phenomena. However, little is known about the intracellular temperature, and the relationship between regenerative function and intracellular temperature of stem cells. In this study, fluorescent nanodiamond (FND) that can be applied as an excellent quantum sensor was used for stem cell labeling. Then, the relationship between the regenerative function of stem cells and the intracellular temperature of stem cells was evaluated by a sensing the optically detected magnetic resonance (ODMR) activity of NV centers in FNDs. FNDs could label adipose tissue-derived stem cells (ASCs) at high efficiency with 24 h incubation, and no cytotoxicity was observed in ASCs labeled with less than 500 µg/mL of FNDs. The ODMR of NV centers in FNDs was confirmed at approximately 2.87 GHz with a characteristic fluorescence spectrum, and the intracellular temperature of living ASCs during several days of culturing could be precisely measured. Moreover, the intracellular temperature was found to influence the production of growth factors and the degree of differentiation into adipocytes and osteocytes. These data suggest that NV centers in FNDs can be used to investigate the relationship between intracellular temperature and cellular functions.</p>

    DOI: 10.11378/organbio.27.185

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  36. Nanobiodevices, AI, and quantum technology for liquid biopsy International journal

    BABA Yoshinobu

    Annual Meeting of the Japanese Society of Toxicology   Vol. 47 ( 0 ) page: S25-2 - 2   2020

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    <p>We have devolved nanobiodevices, quantum technology, and AI for biomedical applications and healthcare, including single cancer cell diagnosis for cancer metastasis, circulating tumour cell (CTC) detection by microfluidic devices, nanopillar devices for ultrafast analysis of genomic DNA and microRNA, nanopore devices for single DNA sequencing, nanowire devices for exosome analysis, single-molecular epigenetic analysis, AI-powered nano-IoT sensors, quantum switching intra vital imaging of iPS cells and stem cells, and quantum technology-based cancer theranostics. </p>

    DOI: 10.14869/toxpt.47.1.0_S25-2

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  37. Metal oxide nanowires microfluidic devices as potential tool for DNA methylation mapping Reviewed International journal

    MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences     page: 1093 - 1094   2020

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  38. The Virtual Issue on Advances in Microfluidics Research Invited Reviewed

    Yoshinobu Baba(Editor)

    Anal. Chem.     2020

  39. 量子生命科学の将来展望 Invited Reviewed

    馬場嘉信、白川昌宏、須原哲也

    Optronics   Vol. 39 ( 464 ) page: 72 - 77   2020

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  40. 九州大学伊都キャンパスにおけるPM2.5の生物学的観点からの分析と実態調査 Reviewed

    三浦夏琳、井手幸子、内藤豊裕、嶋田泰佑、安井隆雄、馬場嘉信、加地範匡

    分析化学   Vol. 69   page: 741 - 746   2020

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  41. Development of an immuno-wall device for the rapid and sensitive detection of EGFR mutations in tumor tissues resected from lung cancer patients. International journal

    Naoyuki Yogo, Tetsunari Hase, Toshihiro Kasama, Keine Nishiyama, Naoya Ozawa, Takahiro Hatta, Hirofumi Shibata, Mitsuo Sato, Kazuki Komeda, Nozomi Kawabe, Kohei Matsuoka, Toyofumi Fengshi Chen-Yoshikawa, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba, Yoshinori Hasegawa

    PloS one   Vol. 15 ( 11 ) page: e0241422   2020

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    Detecting molecular targets in specimens from patients with lung cancer is essential for targeted therapy. Recently, we developed a highly sensitive, rapid-detection device (an immuno-wall device) that utilizes photoreactive polyvinyl alcohol immobilized with antibodies against a target protein via a streptavidin-biotin interaction. To evaluate its performance, we assayed epidermal growth factor receptor (EGFR) mutations, such as E746_A750 deletion in exon 19 or L858R substitution in exon 21, both of which are common in non-small cell lung cancer and important predictors of the treatment efficacy of EGFR tyrosine kinase inhibitors. The results showed that in 20-min assays, the devices detected as few as 1% (E746_A750 deletion) and 0.1% (L858R substitution) of mutant cells. Subsequent evaluation of detection of the mutations in surgically resected lung cancer specimens from patients with or without EGFR mutations and previously diagnosed using commercially available, clinically approved genotyping assays revealed diagnostic sensitivities of the immuno-wall device for E746_A750 deletion and L858R substitution of 85.7% and 87.5%, respectively, with specificities of 100% for both mutations. These results suggest that the immuno-wall device represents a good candidate next-generation diagnostic tool, especially for screening of EGFR mutations.

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  42. Face-selective tungstate ions drive zinc oxide nanowire growth direction and dopant incorporation Invited Reviewed

    Jiangyang Liu, Kazuki Nagashima, Hiroki Yamashita, Wataru Mizukami, Jun Uzuhashi, Takuro Hosomi, Masaki Kanai, Xixi Zhao, Yoshinori Miura, Guozhu Zhang, Tsunaki Takahashi, Masaru Suzuki, Daiki Sakai, Benjarong Samransuksamer, Yong He, Tadakatsu Ohkubo, Takao Yasui, Yuriko Aoki, Johnny Ho, Yoshinobu Baba, and Takeshi Yanagida

    Communications Material     page: 58(2020)   2020

  43. Analysis of particulate matters via surfactant-assisted ionic current sensing Reviewed

    Keiko Fujino, Taisuke Shimada, Takao Yasui, Kazuki Nagashima, Takashi Yanagida, Noritada Kaji, Yoshinobu Baba

    MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences     page: 498 - 499   2020

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    © 2020 CBMS-0001 Toward tracking lifelong exposure history of particulate matters (PMs) for understanding its disease risk, we realized a surfactant-assisted ionic current sensing for analyzing the size and concentration of hydrophobic PMs. Previously, we reported a PM sensor via water film-based collection and micropore-employed ionic current sensing at MicroTAS 2018 [1]. However, an analysis on PM number concentration has not achieved due to a difficulty in sensing hydrophobic PMs. Here, the hydrophobic PMs were detected with the aid of sodium dodecyl sulfate (SDS) and information on PM size and number concentration was obtained.

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  44. Analysis of ion components derived from particulate matter using ion selective electrodes Reviewed

    Haruka Yamauchi, Taisuke Shimada, Takao Yasui, Tatsuro Goda, Noritada Kaji, Yuji Miyahara, Yoshinobu Baba

    MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences     page: 490 - 491   2020

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    © 2020 CBMS-0001 Lifelong exposure history (exposome) of particulate matters (PMs) is essential for understanding environmentally induced health risk, however, diversities in PM size, shape and components are a technical barrier to track the exposome. Previously, we reported a PM sensor utilizing water film-based collection and microfluidics-employed ionic current measurement at MicroTAS 2018 [1], which was only applied to analyze non-soluble PMs. Herein, we realized a potentiometry-based methodology for sensing multiple ion components derived from water-soluble PMs via arrayed ion-selective electrodes (ISEs). NO3-, NH3+, and Na+ ions extracted from a real PM sample were simultaneously detected and analyzing their contents was achieved.

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  45. Microfluidic Mechanotyping of a Single Cell with Two Consecutive Constrictions of Different Sizes and an Electrical Detection System

    Sano Mamiko, Kaji Noritada, Rowat Amy C., Yasaki Hirotoshi, Shao Long, Odaka Hidefumi, Yasui Takao, Higashiyama Tetsuya, Baba Yoshinobu

    ANALYTICAL CHEMISTRY   Vol. 91 ( 20 ) page: 12890-12899   2019.10

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    DOI: 10.1021/acs.analchem.9b02818

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  46. Rapid, Sensitive, and Selective Detection of H5 Hemagglutinin from Avian Influenza Virus Using an Immunowall Device Reviewed

    Chavez Ramos Kenia, Nishiyama Keine, Maeki Masatoshi, Ishida Akihiko, Tani Hirofumi, Kasama Toshihiro, Baba Yoshinobu, Tokeshi Manabu

    ACS OMEGA   Vol. 4 ( 15 ) page: 16683 - 16688   2019.10

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    DOI: 10.1021/acsomega.9b02788

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  47. Substantial Narrowing on the Width of "Concentration Window" of Hydrothermal ZnO Nanowires via Ammonia Addition Reviewed

    Sakai Daiki, Nagashima Kazuki, Yoshida Hideto, Kanai Masaki, He Yong, Zhang Guozhu, Zhao Xixi, Takahashi Tsunaki, Yasui Takao, Hosomi Takuro, Uchida Yuki, Takeda Seiji, Baba Yoshinobu, Yanagida Takeshi

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 1 - 10   2019.10

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    DOI: 10.1038/s41598-019-50641-y

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  48. Exosomal Analysis of ALK Rearrangements by Spin Column with Porous Glass Filter International journal

    Hatta T., Hase T., Ozawa N., Yogo N., Yukawa H., Tanaka H., Onoshima D., Sato M., Hori M., Baba Y., Hasegawa Y.

    JOURNAL OF THORACIC ONCOLOGY   Vol. 14 ( 10 ) page: S676 - S676   2019.10

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  49. Exosomal Analysis of ALK Rearrangements by Spin Column with Porous Glass Filter International journal

    Hatta T, Hase T, Ozawa N, Yogo N, Yukawa H, Tanaka H, Onoshima D, Sato M, Hori M, Baba Y, Hasegawa Y

    JOURNAL OF THORACIC ONCOLOGY   Vol. 14 ( 10 ) page: S676-S676   2019.10

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  50. In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots Reviewed

    Toda Munetoyo, Yukawa Hiroshi, Yamada Jun, Ueno Morio, Kinoshita Shigeru, Baba Yoshinobu, Hamuro Junji

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 60 ( 12 ) page: 4008 - 4020   2019.9

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    DOI: 10.1167/iovs.19-27788

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  51. Ultrasensitive detection of disease biomarkers using an immuno-wall device with enzymatic amplification Reviewed

    Nishiyama Keine, Kasama Toshihiro, Nakamata Seiya, Ishikawa Koya, Onoshima Daisuke, Yukawa Hiroshi, Maeki Masatoshi, Ishida Akihiko, Tani Hirofumi, Baba Yoshinobu, Tokeshi Manabu

    ANALYST   Vol. 144 ( 15 ) page: 4589 - 4595   2019.8

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    DOI: 10.1039/c9an00480g

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  52. Geometry-Based Self-Assembly of Histone-DNA Nanostructures at Single-Nucleotide Resolution Reviewed

    Serag Maged F., Aikeremu Aimaiti, Tsukamoto Ryoko, Piwonski Hubert, Abadi Maram, Kaji Noritada, Dwyer Jason R., Baba Yoshinobu, Habuchi Satoshi

    ACS NANO   Vol. 13 ( 7 ) page: 8155 - 8168   2019.7

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    DOI: 10.1021/acsnano.9b03259

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  53. Micro- and Nanopillar Chips for Continuous Separation of Extracellular Vesicles Reviewed

    Hattori Yuya, Shimada Taisuke, Yasui Takao, Kaji Noritada, Baba Yoshinobu

    ANALYTICAL CHEMISTRY   Vol. 91 ( 10 ) page: 6514 - 6521   2019.5

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    DOI: 10.1021/acs.analchem.8b05538

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  54. Water-Organic Cosolvent Effect on Nucleation of Solution-Synthesized ZnO Nanowires Reviewed

    Akihiro Yuya, Nagashima Kazuki, Hosomi Takuro, Kanai Masaki, Anzai Hiroshi, Takahashi Tsunaki, Zhang Guozhu, Yasui Takao, Baba Yoshinobu, Yanagida Takeshi

    ACS OMEGA   Vol. 4 ( 5 ) page: 8299 - 8304   2019.5

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    DOI: 10.1021/acsomega.9b00945

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  55. Rational Method of Monitoring Molecular Transformations on Metal-Oxide Nanowire Surfaces Reviewed

    Wang Chen, Hosomi Takuro, Nagashima Kazuki, Takahashi Tsunaki, Zhang Guozhu, Kanai Masaki, Zeng Hao, Mizukami Wataru, Shioya Nobutaka, Shimoaka Takafumi, Tamaoka Takehiro, Yoshida Hideto, Takeda Seiji, Yasui Takao, Baba Yoshinobu, Aoki Yuriko, Terao Jun, Hasegawa Takeshi, Yanagida Takeshi

    NANO LETTERS   Vol. 19 ( 4 ) page: 2443 - 2449   2019.4

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    DOI: 10.1021/acs.nanolett.8b05180

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  56. Collection and Sensing of PM2.5 in Microfluidic Devices Reviewed International journal

    Taisuke Shimada, Hirotoshi Yasaki, Takao Yasui, Noritada Kaji, Yoshinobu Baba

    IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED   Vol. 2018-December   page: 240 - 243   2019.2

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    © 2018 IEEE. Toward evaluating health risk of particulate matter with size less than or equal to 2.5 μm (PM2.5), we propose a methodology for realizing the PM2.5 analysis in liquid phase via water film-based collection and microfluidics-based electrical detection. We reported last year that a hydrophilic nanowire surface was utilized in the collection for formation of a water film, which enabled continuous collection of air-floating PM2.5 into liquid phase and followed-by detection. As advanced results, the collected PM2.5 was successfully detected and analyzed via ion current sensing using a micropore. We believe proposed PM2.5 analysis methodology in liquid phase would allow to realize health risk evaluation and reduce health damage.

    DOI: 10.1109/NANOMED.2018.8641523

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  57. Engineering Nanowire-Mediated Cell Lysis for Microbial Cell Identification Reviewed

    Yasui Takao, Yanagida Takeshi, Shimada Taisuke, Otsuka Kohei, Takeuchi Masaki, Nagashima Kazuki, Rahong Sakon, Naito Toyohiro, Takeshita Daiki, Yonese Akihiro, Magofuku Ryo, Zhu Zetao, Kaji Noritada, Kanai Masaki, Kawai Tomoji, Baba Yoshinobu

    ACS NANO   Vol. 13 ( 2 ) page: 2262 - 2273   2019.2

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    DOI: 10.1021/acsnano.8b08959

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  58. Development of a microdevice for facile analysis of theophylline in whole blood by a cloned enzyme donor immunoassay Reviewed

    Nishiyama Keine, Sugiura Kanako, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    LAB ON A CHIP   Vol. 19 ( 2 ) page: 233 - 240   2019.1

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    DOI: 10.1039/c8lc01105b

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  59. Monitoring spin coherence of single nitrogen-vacancy centers in nanodiamonds during pH changes in aqueous buffer solutions Reviewed

    Fujiwara Masazumi, Tsukahara Ryuta, Sera Yoshihiko, Yukawa Hiroshi, Baba Yoshinobu, Shikata Shinichi, Hashimoto Hideki

    RSC ADVANCES   Vol. 9 ( 22 ) page: 12606 - 12614   2019

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    DOI: 10.1039/c9ra02282a

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  60. Nanobiodevices for Cancer Diagnostics and Stem Cell Therapeutics International journal

    Onoshima Daisuke, Yukawa Hiroshi, Baba Yoshinobu

    APPLICATIONS OF MICROFLUIDIC SYSTEMS IN BIOLOGY AND MEDICINE   Vol. 7   page: 275-300 - 300   2019

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    DOI: 10.1007/978-981-13-6229-3_10

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  61. Single cell imaging of transplanted stem cells in the whole cleared tissue by quantum dots

    Mizumaki Toshiki, Yukawa Hiroshi, A. Susaki Etsuo, R. Ueda Hiroki, Baba Yoshinobu

    Organ Biology   Vol. 26 ( 2 ) page: 199 - 204   2019

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    <p><i>In vivo</i> imaging technology can detect and diagnose a total of transplanted stem cells remains unestablished. In order to enhance the safety and treatment effect of regenerative medicine, it is necessary to understand where transplanted stem cells accumulate in the tissue and how accumulated cells behave in the tissue at a single cell level. In this study, we challenged the innovative diagnosis of transplanted stem cells in acute liver failure model mice by quantum dots (QDs) fluorescence imaging and whole tissue clearing technologies.</p><p>After transplantation of stem cells labeled with QDs655 into the living body of the acute liver failure model mice through tail vein, it was confirmed that the transplanted stem cells were mainly accumulated in the lung and liver of the mice using <i>in vivo</i> imaging system. In addition, we succeeded in revealing the spatiotemporal distribution of transplanted stem cells at the single cell level by organ clearing and 3D imaging of organs using light sheet fluorescence microscopy.</p>

    DOI: 10.11378/organbio.26.199

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  62. 量子ドットを用いた透明化組織内移植幹細胞イメージング技術の開発

    水巻 登志樹, 湯川 博, 小野島 大介, 洲崎 悦生, 上田 泰己, 馬場 嘉信

    生体医工学   Vol. 57 ( 0 ) page: S177_1-S177_1   2019

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    <p>幹細胞移植は幹細胞をそのまま、あるいは前駆細胞に分化させた状態で血流に乗せて移植する治療法であり、幹細胞を用いた組織や臓器の再構築が未だ困難とされている疾病に対して有効な治療法であるとして近年注目を集めている。幹細胞移植の実現に向けては、安全性が十分に確保されており、尚且つ治療効果が大きい移植プロトコールを確立する必要があり、この課題の解決に向けて、移植幹細胞の体内動態や生着部位を高感度にイメージングし、どのように治療効果を発揮しているかを解明する必要がある。しかし、これまで生体内のすべての移植幹細胞を網羅的にイメージング診断できる技術は確立されていない。臓器や組織は光を吸収・散乱する様々な物質から構成されており、光の透過性が極めて低いため、二光子励起顕微鏡などを用いても表面上のしかも限られた視野での観察に留まっているのが現状である。そこで我々は、臓器の効率的な透明化が可能な技術に注目し量子ドットを用いた幹細胞蛍光イメージング技術と融合することで、急性肝不全モデルマウスにおける移植幹細胞の網羅的、且つ単一細胞レベルの解像度でのイメージングを可能にする革新的診断技術の確立に取り組んだ。</p>

    DOI: 10.11239/jsmbe.Annual57.S177_1

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  63. 量子ドットによる幹細胞由来エクソソームイメージングと再生医療への応用

    公文 優花, 湯川 博, 小野島 大介, 馬場 嘉信

    生体医工学   Vol. 57 ( 0 ) page: S81_1-S81_1   2019

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    <p>幹細胞による再生治療メカニズム解明は、再生医療の更なる安全性、治療効果向上において極めて重要である。幹細胞は自己複製能と多分化能を持つ特殊な細胞であり、障害部位への特異的な集積能力や再生因子産性能を持つことから患者に移植することで治療効果を発揮することが知られている。更に、近年では幹細胞から放出されるエクソソームも同様に治療効果を持つことがわかっており、新規治療ツールとして注目され始めている。しかし、エクソソームの詳細な生体内挙動及び細胞間移動等について解析できる技術が乏しく、再生機能の役割については未だ未解明のままである。本研究では、エクソソームを生体内で高感度に検出できる技術の確立を目指した。最先端量子ナノ材料である量子ドットをグルコース修飾することで、もともと細胞が持つグルコーストランスポーターを通して細胞内に導入することに成功した。また、グルコーストランスポーターを持つとされるエクソソームにおいても同様に内部への導入が確認された。エクソソームの内部に導入することで、膜上に蛍光色素を付着させる従来法に比べてより安定で高感度のラベル化に成功した。</p>

    DOI: 10.11239/jsmbe.Annual57.S81_1

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  64. Analyzing peptide adsorption states via nanowire-employed infrared spectrometry

    Hiroki Naito, Takao Yasui, Taisuke Shimada, Nobutaka Shioya, Takafumi Shimoaka, Masayoshi Tanaka, Kazuki Nagasima, Mina Okochi, Takeshi Yanagida, Takeshi Hasegawa, Yoshinobu Baba

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page: 1206 - 1207   2019

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    © 2019 CBMS-0001. Peptides optimally binding to solid surfaces are a promising candidate for adding bio-affinity, however, their binding states are not fully revealed. Herein, we realized a methodology for analyzing peptide adsorption states via employing nanowires and infrared (IR) p-polarized multiple-angle incidence resolution spectrometry (pMAIRS). Our methodology enabled to provide large crystalline surface for peptide adsorption, and enhance signal intensities. We found that a modelled peptide had different adsorption states among crystal axes. Analyzing peptide adsorption states can pave the way for controlling adsorbed states, and moreover, using full potentials of peptide.

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  65. 酸化物ナノワイヤによる尿中microRNAの回収と解析 Invited Reviewed

    長縄豪、安井隆雄、柳田剛、加地範匡、長島一樹、鷲尾隆、馬場嘉信

    化学とマイクロ・ナノシステム   Vol. 18   page: 34 - 35   2019

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  66. Rational Method to Monitor Molecular Transformations on Metal Oxide Nanowire Surfaces Invited Reviewed

    Wang C., Hosomi T., Nagashima K., Takahashi T., Zhang G., Kanai M., Zeng H., Mizukami W., Shioya N., Shimoaka T., Tamaoka T., Yoshida H., Takeda S., Yasui T., Baba Y., Aoki Y., Terao J., Hasegawa T., Yanagida T.

    Nano Lett.   Vol. 19 ( 4 ) page: 2443 - 2449   2019

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  67. Identifying multiple viral species at a single particle level using a combination of nanopores and machine leaning approach Reviewed International journal

    Arima A.

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page: 1238 - 1239   2019

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  68. Hybridization-based DNA analysis by self-heating nanowire microfluidic devices Reviewed International journal

    Takahashi H.

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page: 720 - 721   2019

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  69. Fluorescence signal amplification for sensitive enzyme immunoassay utilizing an immuno-wall Reviewed International journal

    Nishiyama K.

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page: 689 - 690   2019

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    Publishing type:Research paper (scientific journal)   Publisher:23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019  

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  70. Discriminating drug-resistant bacteria using AI analysis on fine current changes from inner ION leakages Reviewed International journal

    Yoshikawa A.

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page: 852 - 853   2019

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  71. Analyzing peptide adsorption states via nanowire-employed infrared spectrometry Reviewed International journal

    Naito H.

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page: 1206 - 1207   2019

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    Publishing type:Research paper (scientific journal)   Publisher:23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019  

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  72. Microfluidic Mechanotyping of a Single Cell with Two ConsecutiveConstrictions of Different Sizes and an Electrical Detection System. Invited Reviewed

    Mamiko Sano, Noritada Kaji, Amy Rowat, Hirotoshi Yasaki, Long Shao, Hidefumi Okada, Takao Yasui, Tetsuya Higashiyama , Yoshinobu Baba

    Anal. Chem.   Vol. 91   page: 12890 - 12899   2019

  73. Single-cell microscopic raman spectroscopy for rapid microbial detection Reviewed International journal

    Onoshima D.

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page: 1374 - 1375   2019

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  74. 量子ナノ材料による移植幹細胞in vivo蛍光イメージングと再生医療 Invited Reviewed

    湯川博、馬場嘉信

    化学工業   Vol. 70   page: 234 - 240   2019

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  75. Salivary microrna corection and analysis using nanocellulose for domiciliary cancer diagnosis

    Naoya Mizukami, Takao Yasui, Hironao Koga, Yoshinobu Baba

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page: 894 - 895   2019

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    © 2019 CBMS-0001. Analyzing microRNAs in our body allowed us to investigate our various vital in Here [1], our aim is that discovering additional vital information based on microRNAs from saliva samples. MicroRNAs in body fluids are known to obtain higher stability in body fluids via encapsulation in extracellular vesicles with over 40-nm diameter [2]. To capture the vesicles, we conceived an idea to use nanocellulose with several 10- to several 100-nm pore sizes. The nanocellulose made it possible to extract over 1000 species of microRNAs from 10 µL saliva within 20 s, compared to ultracentrifugation, which required over 180 min and 10 µL saliva to extract around 600 species of microRNAs.

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  76. 分子夾雑生命化学に基づく新規計測技術のがん診断への展開 ナノバイオ夾雑環境デバイスによる肝がん細胞由来エクソソームの血管新生評価 Invited Reviewed

    湯川博、馬場嘉信

    化学と工業   Vol. 72   page: 410 - 412   2019

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  77. ナノバイオデバイスとAIが拓くSociety5.0・健康長寿社会 Invited Reviewed

    馬場嘉信

    化学とマイクロ・ナノシステム   Vol. 18   page: 1 - 6   2019

  78. 分子夾雑と診断 がん医療への展開 Invited Reviewed

    小野島大介、馬場嘉信

    現代化学   Vol. 576   page: 37 - 39   2019

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  79. PM2.5 Particle Detection in a Microfluidic Device by Using Ionic Current Sensing

    Shimada Taisuke, Yasaki Hirotoshi, Yasui Takao, Yanagida Takeshi, Kaji Noritada, Kanai Masaki, Nagashima Kazuki, Kawai Tomoji, Baba Yoshinobu

    ANALYTICAL SCIENCES   Vol. 34 ( 12 ) page: 1347-1349   2018.12

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  80. Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer Reviewed

    Shimada Taisuke, Yasui Takao, Yokoyama Asami, Goda Tatsuro, Hara Mitsuo, Yanagida Takeshi, Kaji Noritada, Kanai Masaki, Nagashima Kazuki, Miyahara Yuji, Kawai Tomoji, Baba Yoshinobu

    LAB ON A CHIP   Vol. 18 ( 21 ) page: 3225 - 3229   2018.11

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    DOI: 10.1039/c8lc00438b

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  81. Development of the immuno-wall device for rapid detection of ALK and ROS1 fusions in lung cancer

    Yogo N., Hase T., Kasama T., Hatta T., Ozawa N., Sato M., Kaji N., Tokeshi M., Baba Y., Hasegawa Y.

    ANNALS OF ONCOLOGY   Vol. 29   page: .   2018.11

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  82. Development of the immuno-wall device for rapid detection of ALK and ROS1 fusions in lung cancer International journal

    Yogo N, Hase T, Kasama T, Hatta T, Ozawa N, Sato M, Kaji N, Tokeshi M, Baba Y, Hasegawa Y

    ANNALS OF ONCOLOGY   Vol. 29   page: .   2018.11

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    DOI: 10.1093/annonc/mdy441.027

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  83. Effective Transplantation of 2D and 3D Cultured Hepatocyte Spheroids Confirmed by Quantum Dot Imaging Reviewed

    Okumura Hiroki, Nanizawa Eri, Nakanishi Anna, Yukawa Hiroshi, Hashita Tadahiro, Iwao Takahiro, Baba Yoshinobu, Ishikawa Tetsuya, Matsunaga Tamihide

    ADVANCED BIOSYSTEMS   Vol. 2 ( 8 )   2018.8

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    DOI: 10.1002/adbi.201800137

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  84. Adipose-derived mesenchymal stem cells attenuate rejection in a rat lung transplantation model Reviewed

    Watanabe Hironosuke, Tsuchiya Tomoshi, Shimoyama Koichiro, Shimizu Akira, Akita Sadanori, Yukawa Hiroshi, Baba Yoshinobu, Nagayasu Takeshi

    JOURNAL OF SURGICAL RESEARCH   Vol. 227   page: 17-27   2018.7

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    DOI: 10.1016/j.jss.2018.01.016

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  85. Determination of baclofen and vigabatrin by microchip electrophoresis with fluorescence detection: application of field-enhanced sample stacking and dynamic pH junction Reviewed

    Zeid Abdallah M., Kaji Noritada, Nasr Jenny Jeehan M., Belal Fathalla, Walash Mohamed I., Baba Yoshinobu

    NEW JOURNAL OF CHEMISTRY   Vol. 42 ( 12 ) page: 9965-9974   2018.6

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    DOI: 10.1039/c8nj00829a

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  86. Low-autofluorescence fluoropolymer membrane filters for cell filtration Reviewed International journal

    Naoto Kihara, Daiki Kuboyama, Daisuke Onoshima, Kenji Ishikawa, Hiromasa Tanaka, Naoya Ozawa, Tetsunari Hase, Ryohei Koguchi, Hiroshi Yukawa, Hidefumi Odaka, Yoshinori Hasegawa, Yoshinobu Baba, Masaru Hori

    Japanese Journal of Applied Physics   Vol. 57 ( 6 )   2018.6

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    © 2018 The Japan Society of Applied Physics. A fluoropolymer membrane filter with through-holes was fabricated by photolithographic patterning and the dry etching method. 380,000 highly packed through-holes, each with a diameter of 7 µm were able to cover a whole area with a diameter of 13 mm. Ethylene tetrafluoroethylene (ETFE) was used as the membrane, which was suitable for the fluorescence detection of rare cells such as circulating tumor cells (CTCs) in human blood. The device fabrication for the size based capture of rare cells in blood such as CTCs is realized in this study.

    DOI: 10.7567/JJAP.57.06JF03

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  87. Effects of cold exposure on metabolites in brown adipose tissue of rats Reviewed

    Hiroshima Yuka, Yamamoto Takenori, Watanabe Masahiro, Baba Yoshinobu, Shinohara Yasuo

    MOLECULAR GENETICS AND METABOLISM REPORTS   Vol. 15   page: 36-42   2018.6

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    DOI: 10.1016/j.ymgmr.2018.01.005

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  88. Cell Deposition Microchip with Micropipette Control over Liquid Interface Motion Reviewed

    Onoshima Daisuke, Hattori Yuya, Yukawa Hiroshi, Ishikawa Kenji, Hori Masaru, Baba Yoshinobu

    CELL MEDICINE   Vol. 10   2018.5

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    DOI: 10.1177/2155179017733152

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  89. A real-time simultaneous measurement on a microfluidic device for individual bacteria discrimination Reviewed

    Yasaki Hirotoshi, Yasui Takao, Yanagida Takeshi, Kaji Noritada, Kanai Masaki, Nagashima Kazuki, Kawai Tomoji, Baba Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL   Vol. 260   page: 746-752   2018.5

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    DOI: 10.1016/j.snb.2018.01.079

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  90. In Vivo Imaging Technology of Transplanted Stem Cells Using Quantum Dots for Regenerative Medicine Reviewed

    Yukawa Hiroshi, Baba Yoshinobu

    ANALYTICAL SCIENCES   Vol. 34 ( 5 ) page: 525-532   2018.5

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  91. In Vivo Imaging Technology of Transplanted Stem Cells Using Quantum Dots for Regenerative Medicine Reviewed International journal

    Hiroshi Yukawa, Yoshinobu Baba

    ANALYTICAL SCIENCES   Vol. 34 ( 5 ) page: 525 - 532   2018.5

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    Quantum dots (QDs) have excellent fluorescence properties in comparison to traditional fluorescence probes. Thus, the optical application of QDs is rapidly expanding to each field of analytical chemistry. In this review paper, we reviewed the application of QDs to regenerative medicine, especially stem cell transplantation therapy. The labeling of stem cells using QDs composed of semiconductor materials in combination with a chemical substance, poly-cationic liposome and cell penetrating peptide is reported. In addition, the influence of QD labeling on the pluripotency of stem cells is also reported. Finally, the in vivo imaging of transplanted stem cells in mice by QDs emitting fluorescence in the near-infrared region, which can be detected by in vivo fluorescence imaging systems such as IVIS and SAI-1000, is described. The future prospects for stem cell imaging technology by QDs are also discussed.

    DOI: 10.2116/analsci.17R005

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    PubMed

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  92. Imaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells Reviewed

    Yukawa Hiroshi, Suzuki Kaoru, Aoki Keita, Arimoto Tomoko, Yasui Takao, Kaji Noritada, Ishikawa Tetsuya, Ochiya Takahiro, Baba Yoshinobu

    SCIENTIFIC REPORTS   Vol. 8   2018.4

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    DOI: 10.1038/s41598-018-24563-0

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  93. 尿中マイクロRNAから「がん」を特定 Reviewed

    安井隆雄、馬場嘉信

    ここまで進んだ「がんの検査と診断」 ライフライン21 がんの先進医療   Vol. 29   page: 30-34   2018.4

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  94. Quantitative Evaluation of Dielectric Breakdown of Silicon Micro- and Nanofluidic Devices for Electrophoretic Transport of a Single DNA Molecule Reviewed

    Sano Mamiko, Kaji Noritada, Wu Qiong, Naito Toyohiro, Yasui Takao, Taniguchi Masateru, Kawai Tomoji, Baba Yoshinobu

    MICROMACHINES   Vol. 9 ( 4 )   2018.4

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    DOI: 10.3390/mi9040180

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  95. 【ここまで進んだ「がんの検査と診断」】診断(肺がん・膵がん・肝がん・膀胱がん・前立腺がん) 尿中マイクロRNAから「がん」を特定

    馬場 嘉信, 安井 隆雄

    ライフライン21がんの先進医療   Vol. 29   page: 30 - 34   2018.4

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  96. 幹細胞標識用超低毒性量子ドットFluclair™試薬の開発 Reviewed

    湯川 博, 馬場嘉信

    和光純薬時報   Vol. 86 ( 2 ) page: 2 - 4   2018.4

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  97. Effect of Channel Geometry on Ionic Current Signal of a Bridge Circuit Based Microfluidic Channel Reviewed

    Yasaki Hirotoshi, Yasui Takao, Yanagida Takeshi, Kaji Noritada, Kanai Masaki, Nagashima Kazuki, Kawai Tomoji, Baba Yoshinobu

    CHEMISTRY LETTERS   Vol. 47 ( 3 ) page: 350-353   2018.3

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    DOI: 10.1246/cl.171139

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  98. Robust Ionic Current Sensor for Bacterial Cell Size Detection Reviewed

    Yasaki Hirotoshi, Shimada Taisuke, Yasui Takao, Yanagida Takeshi, Kaji Noritada, Kanai Masaki, Nagashima Kazuki, Kawai Tomoji, Baba Yoshinobu

    ACS SENSORS   Vol. 3 ( 3 ) page: 574-579   2018.3

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    DOI: 10.1021/acssensors.8b00045

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  99. Facile fabrication of a poly(ethylene terephthalate) membrane filter with precise arrangement of through-holes Reviewed

    Kihara Naoto, Odaka Hidefumi, Kuboyama Daiki, Onoshima Daisuke, Ishikawa Kenji, Baba Yoshinobu, Hori Masaru

    JAPANESE JOURNAL OF APPLIED PHYSICS   Vol. 57 ( 3 )   2018.3

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    DOI: 10.7567/JJAP.57.037001

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  100. Quantum Dot-Peptide Nanoassembly on Mesoporous Silica Nanoparticle for Biosensing Reviewed International journal

    Pillai Sreenadh Sasidharan, Yukawa Hiroshi, Onoshima Daisuke, Biju Vasudevanpillai, Baba Yoshinobu

    NANO HYBRIDS AND COMPOSITES   Vol. 19   page: 55-72 - 72   2018.2

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    DOI: 10.4028/www.scientific.net/NHC.19.55

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  101. Nanobiodevice-Based Cancer Theranostics

    Baba Yoshinobu

    CANCER SCIENCE   Vol. 109   page: 146-146   2018.1

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  102. Application of biomaterials in interdisciplinary approaches for cancer research

    Baba Yoshinobu, Kano Mitsunobu

    CANCER SCIENCE   Vol. 109   page: 146-146   2018.1

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  103. Application of biomaterials in interdisciplinary approaches for cancer research

    Baba Yoshinobu, Kano Mitsunobu

    CANCER SCIENCE   Vol. 109   page: 146-146   2018.1

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  104. Nanobiodevice-Based Cancer Theranostics

    Baba Yoshinobu

    CANCER SCIENCE   Vol. 109   page: 146-146   2018.1

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  105. Collection and Sensing of PM2.5 in Microfluidic Devices

    Shimada Taisuke, Yasaki Hirotoshi, Yasui Takao, Kaji Noritada, Baba Yoshinobu

    2018 IEEE 12TH INTERNATIONAL CONFERENCE ON NANO/MOLECULAR MEDICINE AND ENGINEERING (IEEE - NANOMED)     page: 240-243   2018

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  106. Comparison of conservative treatment versus transcatheter arterial embolisation for the treatment of spontaneously ruptured hepatocellular carcinoma

    Shinmura K.

    Polish Journal of Radiology   Vol. 83   page: e311-e318   2018

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    DOI: 10.5114/pjr.2018.77024

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  107. PM <inf>2.5</inf> Particle detection in a microfluidic device by using ionic current sensing Reviewed

    Taisuke Shimada, Hirotoshi Yasaki, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

    Analytical Sciences   Vol. 34 ( 12 ) page: 1347 - 1349   2018

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    © 2018 The Japan Society for Analytical Chemistry. We have demonstrated a PM 2.5 analysis method that adds information on the number concentration and size by using microfluidic-based ionic current sensing with a bridge circuit. The bridge circuit allows for suppression of the background current and the detection of small PM 2.5 particles, even if a relatively large micropore is used. This is the first demonstration of the detection of PM 2.5 particles via ionic current sensing; our method enables analyses of both the number concentration and size.

    DOI: 10.2116/analsci.18C018

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    PubMed

    CiNii Article

  108. Cell deformability measurement device for labeled-free cancer cells discriminating using ionic current detection Reviewed International journal

    T. Suzuki, N. Kaji, H. Yasaki, T. Yasui, Y. Baba

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 1   page: 347 - 348   2018

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    Copyright© (2018) by Chemical and Biological Microsystems Society.All rights reserved. In this study, we have developed ionic current detection device that can discriminate cells by measurement of cell deformability for detecting circulating tumor cells (CTC). We successfully discriminated CTC model from leukocyte model without any fluorescent labels by using the device. Moreover, we could detect relatively small CTCs compared to blood cells, which are difficult to detect by conventional filter devices. This device is expected as a new cancer diagnostic device that is simple and highly sensitive.

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  109. Microheater-nanowires device for detection of cell-free circulating methylated DNA Reviewed International journal

    Hiromi Takahashi, Takao Yasui, Keiko Shinjo, Noritada Kaji, Akimitsu Okamoto, Yoshinobu Baba

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 4   page: 1886 - 1888   2018

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    Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved. Detecting of cell-free circulating methylated DNA could be a promising method for early diagnosis of cancer. Here we have developed the microheater - zinc oxide nanowires (ZnO-NWs) structures embedded in the microchannel device for capturing DNA via electrostatic interaction. We found that 60% of DNA could be captured on ZnO-NWs. Additionally, the microheater, which constantly enables to generate heat, can denature double stranded DNA (dsDNA) to single stranded DNA (ssDNA). Finally, ICON Probe, which is an artificial ssDNA probe for DNA methylation, was introduced inside a device to bind to ssDNA for DNA methylation detection.

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  110. Exosome isolation toward cancer diagnosis using glass filter with nanoporous structure Reviewed International journal

    Keita Aoki, Hiroshi Yukawa, Daisuke Onoshima, Shuji Yamazaki, Naoto Kihara, Ryohei Koguchi, Kumiko Takahashi, Hidefumi Odaka, Kenji Ishikawa, Masaru Hori, Yoshinobu Baba

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 3   page: 1409 - 1410   2018

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    Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved. We present a study of centrifugal filtration device toward easy-to-use approach of non-invasive liquid biopsy for cancer diagnosis by cell-derived nanoscale vesicles (exosomes). A phase-dispersed glass filter having nanoporous structure was embedded into a spin column to trap exosomes with small centrifuge. This device enabled over 90% exosome isolation from biological samples within 10 minutes.

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  111. Exosome isolation toward cancer diagnosis using glass filter with nanoporous structure Reviewed International journal

    Aoki K.

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 3   page: 1409 - 1410   2018

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    Publishing type:Research paper (international conference proceedings)   Publisher:22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018  

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  112. Cell deformability measurement device for labeled-free cancer cells discriminating using ionic current detection Reviewed International journal

    Suzuki T.

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 1   page: 347 - 348   2018

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    Publishing type:Research paper (international conference proceedings)   Publisher:22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018  

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  113. Microheater-nanowires device for detection of cell-free circulating methylated DNA Reviewed International journal

    Takahashi H.

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 4   page: 1886 - 1888   2018

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  114. Selective molecular recognition using molecular fingerprinted nanowires Reviewed International journal

    Horiuchi M.

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 2   page: 659 - 660   2018

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  115. Selective molecular recognition using molecular fingerprinted nanowires Reviewed International journal

    Masafumi Horiuchi, Takao Yasui, Kazuki Nagashima, Takeshi Yanagida, Yoshinobu Baba

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 2   page: 659 - 660   2018

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    Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved. Molecular recognition methods such as those found in antigen-antibody reactions are attracting attention. We demonstrated more selective molecular recognition through focusing on not only intermolecular interaction but also the shape of the molecules. Here, we fabricated molecular shapes of aniline on the titanium oxide thin film on the core-shell structure of zinc oxide/titanium oxide nanowires, and recognized aniline, selectively, using the aniline molecular shaped nanowires.

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  116. PM2.5 analysis in liquid phase via water film-based collection and microfluidics-based electrical detection Reviewed International journal

    Shimada T.

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 1   page: 270 - 271   2018

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  117. PM2.5 analysis in liquid phase via water film-based collection and microfluidics-based electrical detection Reviewed International journal

    Taisuke Shimada, Hirotoshi Yasaki, Takao Yasui, Akihide Hibara, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 1   page: 270 - 271   2018

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    Copyright© (2018) by Chemical and Biological Microsystems Society.All rights reserved. Toward evaluation of health risk of particulate matter with size less than or equal to 2.5 µm (PM2.5), we propose a methodology for realizing the PM2.5 analysis in liquid phase via water film-based collection and microfluidics-based electrical detection. A hydrophilic nanowire surface was utilized in the collection for forming a water film, which enabled continuous collection of air-floating PM2.5 into liquid phase and followed-by detection. The collected PM2.5 was electrically detected and analyzed via ionic current sensing with a micropore. We believe proposed PM2.5 analysis methodology in liquid phase would allow to realize health risk evaluation and reduce health damage.

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  118. Oncogene mutation analysis of circulating tumor cells using single-cell membrane separation and DNA amplification Reviewed International journal

    Onoshima D.

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 3   page: 1291 - 1293   2018

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  119. Oncogene mutation analysis of circulating tumor cells using single-cell membrane separation and DNA amplification Reviewed International journal

    Daisuke Onoshima, Daiki Kuboyama, Naoto Kihara, Hiromasa Tanaka, Tetsunari Hase, Hiroshi Yukawa, Kenji Ishikawa, Hidefumi Odaka, Yoshinori Hasegawa, Masaru Hori, Yoshinobu Baba

    22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018   Vol. 3   page: 1291 - 1293   2018

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    Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved. We present a study of genomic profiling for circulating tumor cells (CTCs) using a blood microfiltration system. DNA amplification of CTCs was performed with a microfilter for single cancer cells in a clinical setting. This strategy was successfully used to detect the driver mutations in epidermal growth factor (EGF) receptor oncogenes by quantitative PCR and characterize the dosing effect of molecularly targeted drug for lung cancer.

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  120. Microfluidic immunoassay devices as next-generation cancer and medical diagnostics platform

    Kasama T.

    Next Generation Point-of-care Biomedical Sensors Technologies for Cancer Diagnosis     page: 305-322   2017.12

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    DOI: 10.1007/978-981-10-4726-8_13

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  121. Discriminating single-bacterial shape using low-aspect-ratio pores Reviewed

    Tsutsui Makusu, Yoshida Takeshi, Yokota Kazumichi, Yasaki Hirotoshi, Yasui Takao, Arima Akihide, Tonomura Wataru, Nagashima Kazuki, Yanagida Takeshi, Kaji Noritada, Taniguchi Masateru, Washio Takashi, Baba Yoshinobu, Kawai Tomoji

    SCIENTIFIC REPORTS   Vol. 7   2017.12

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    DOI: 10.1038/s41598-017-17443-6

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  122. Unveiling massive numbers of cancer-related urinary-microRNA candidates via nanowires Reviewed

    Yasui Takao, Yanagida Takeshi, Ito Satoru, Konakade Yuki, Takeshita Daiki, Naganawa Tsuyoshi, Nagashima Kazuki, Shimada Taisuke, Kaji Noritada, Nakamura Yuta, Thiodorus Ivan Adiyasa, He Yong, Rahong Sakon, Kanai Masaki, Yukawa Hiroshi, Ochiya Takahiro, Kawai Tomoji, Baba Yoshinobu

    SCIENCE ADVANCES   Vol. 3 ( 12 )   2017.12

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    DOI: 10.1126/sciadv.1701133

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  123. Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers Reviewed

    M. Maeki, Y. Fujishima, Y. Sato, T. Yasui, N. Kaji, A. Ishida, H. Tani, Y. Baba, H. Harashima, M. Tokeshi

    PLoS One     2017.11

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    DOI: 10.1371/journal.pone.0187962

  124. Development of the immuno-wall device for rapid, low-cost detection of EGFR mutations in tumor samples from patients with lung cancer

    Yogo N., Hase T., Kasama T., Ozawa N., Sato M., Kaji N., Tokeshi M., Baba Y., Hasegawa Y.

    ANNALS OF ONCOLOGY   Vol. 28   page: .   2017.11

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  125. Development of the immuno-wall device for rapid, low-cost detection of EGFR mutations in tumor samples from patients with lung cancer

    Yogo N, Hase T, Kasama T, Ozawa N, Sato M, Kaji N, Tokeshi M, Baba Y, Hasegawa Y

    ANNALS OF ONCOLOGY   Vol. 28   page: .   2017.11

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  126. NANOBIODEVICES AND AI FOR SOCIETY 5.0: SUPER SMART SOCIETY Reviewed

    Y. Baba

    Micro Total Analysis Systems 2017     page: 1-2   2017.10

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  127. Millisecond mechanophenotyping of stem cells by electrical detection in microfluidic constrictions Reviewed

    N. Kaji, S. Ito, H. Yasaki, T. Yasui, H. Yukawa, Y. Baba

    Micro Total Analysis Systems 2017     page: 832-833   2017.10

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  128. CELL DEPOSITION AND ISOLATION WITH MICROPIPETTE CONTROL OVER LIQUID INTERFACE MOTION IN MICROFLUIDIC CHANNEL Reviewed

    Daisuke Onoshima, Hiroshi Yukawa, Yuya Hattori, Kenji Ishikawa, Masaru Hori, Yoshinobu Baba

    Micro Total Analysis Systems 2017     page: 679-680   2017.10

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  129. LEUKOCYTE DEPLETION AND SIZE-BASED ENRICHMENT OF CIRCULATING TUMOR CELLS WITH PRESSURE-SENSING MICROFILTRATION SYSTEM Reviewed

    D. Kuboyama, D. Onoshima, N. Kihara, H. Tanaka, T. Hase, H. Yukawa, K. Ishikawa, H. Odaka, Y. Hasegawa, M. Hori, Y. Baba

    Micro Total Analysis Systems 2017     page: 882-883   2017.10

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  130. PM2.5 collection into aqueous solution via hydrophilic oxide nanowire surface Reviewed

    T. Shimada, T. Yasui, A. Hibara, H. Yasaki, T. Yanagida, M. Hara, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2017     page: 1433-1434   2017.10

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  131. Nanowires enabling cancer diagnosis from 1 mL urine Invited Reviewed

    T. Naganawa, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, H. Yukawa, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2017     page: 1271-1272   2017.10

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  132. Extracellular vesicles separation by electroosmotic flow-driven deterministic lateral displacement in nanopillar chips Reviewed

    N. Kaji, Y. Hattori, H. Yasaki, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2017     page: 904-905   2017.10

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  133. A zinc oxide nanowires devices for extracellular vesicles isolation and purification Reviewed

    I. A. Thiodorus, N. Kaji, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2017     page: 886-887   2017.10

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  134. A zinc oxide nanowires devices for extracellular vesicles isolation and purification Reviewed

    I. A. Thiodorus, N. Kaji, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2017     page: 886-887   2017.10

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  135. LEUKOCYTE DEPLETION AND SIZE-BASED ENRICHMENT OF CIRCULATING TUMOR CELLS WITH PRESSURE-SENSING MICROFILTRATION SYSTEM Reviewed

    D. Kuboyama, D. Onoshima, N. Kihara, H. Tanaka, T. Hase, H. Yukawa, K. Ishikawa, H. Odaka, Y. Hasegawa, M. Hori, Y. Baba

    Micro Total Analysis Systems 2017     page: 882-883   2017.10

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  136. Extracellular vesicles separation by electroosmotic flow-driven deterministic lateral displacement in nanopillar chips Reviewed

    N. Kaji, Y. Hattori, H. Yasaki, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2017     page: 904-905   2017.10

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  137. CELL DEPOSITION AND ISOLATION WITH MICROPIPETTE CONTROL OVER LIQUID INTERFACE MOTION IN MICROFLUIDIC CHANNEL Reviewed

    Daisuke Onoshima, Hiroshi Yukawa, Yuya Hattori, Kenji Ishikawa, Masaru Hori, Yoshinobu Baba

    Micro Total Analysis Systems 2017     page: 679-680   2017.10

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    Language:English   Publishing type:Research paper (other academic)  

  138. Millisecond mechanophenotyping of stem cells by electrical detection in microfluidic constrictions Reviewed

    N. Kaji, S. Ito, H. Yasaki, T. Yasui, H. Yukawa, Y. Baba

    Micro Total Analysis Systems 2017     page: 832-833   2017.10

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  139. PM2.5 collection into aqueous solution via hydrophilic oxide nanowire surface Reviewed

    T. Shimada, T. Yasui, A. Hibara, H. Yasaki, T. Yanagida, M. Hara, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2017     page: 1433-1434   2017.10

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  140. Nanowires enabling cancer diagnosis from 1 mL urine Invited Reviewed

    T. Naganawa, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, H. Yukawa, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2017     page: 1271-1272   2017.10

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  141. NANOBIODEVICES AND AI FOR SOCIETY 5.0: SUPER SMART SOCIETY Reviewed

    Y. Baba

    Micro Total Analysis Systems 2017     page: 1-2   2017.10

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  142. Optimization of the nanofluidic design for label-free detection of biomolecules using a nanowall array Reviewed

    Taiga Ajiri, Takao Yasui, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Yoshinobu Baba, Manabu Tokeshi

    Sensors and Actuators B: Chemical   Vol. 250   page: pp.39-43   2017.10

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    DOI: 10.1016/j.snb.2017.04.150

  143. 尿を使った疾病診断を目指したナノワイヤ空間の創製 Reviewed

    安井隆雄、加地範匡、馬場嘉信

    化学と工業   Vol. 68 ( 10 ) page: 768-772   2017.10

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  144. Nanowire Spaces for Urine-based Disease Diagnosis

      Vol. 68 ( 10 ) page: 768 - 772   2017.10

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  145. Substantial Expansion of Detectable Size Range in Ionic Current Sensing through Pores by Using a Microfluidic Bridge Circuit Reviewed

    Hirotoshi Yasaki, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, and Yoshinobu Baba

    J. Am. Chem. Soc.   Vol. 139 ( 40 ) page: 14137–14142   2017.9

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    DOI: 10.1021/jacs.7b06440

  146. 量子ドットによる移植幹細胞in vivo 蛍光イメージング Reviewed

    湯川博、馬場嘉信

      Vol. 24 ( 2 ) page: 81-86   2017.8

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  147. Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells Reviewed

    Ryoichiro Doi, Tomoshi Tsuchiya, Norisato Mitsutake, Satoshi Nishimura, Mutsumi Matsuu-Matsuyama, Yuka Nakazawa, Tomoo Ogi, Sadanori Akita, Hiroshi Yukawa, Yoshinobu Baba, Naoya Yamasaki, Keitaro Matsumoto, Takuro Miyazaki, Ryotaro Kamohara, Go Hatachi, Hideyori Sengyoku, Hironosuke Watanabe, Tomohiro Obata, Laura E. Niklason, and Takeshi Nagayasu

    Scientific Reports (Nature Publishing Group)     2017.8

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    DOI: 10.1038/s41598-017-09115-2

  148. Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells

    Doi Ryoichiro, Tsuchiya Tomoshi, Mitsutake Norisato, Nishimura Satoshi, Matsuu-Matsuyama Mutsumi, Nakazawa Yuka, Ogi Tomoo, Akita Sadanori, Yukawa Hiroshi, Baba Yoshinobu, Yamasaki Naoya, Matsumoto Keitaro, Miyazaki Takuro, Kamohara Ryotaro, Hatachi Go, Sengyoku Hideyori, Watanabe Hironosuke, Obata Tomohiro, Niklason Laura E., Nagayasu Takeshi

    SCIENTIFIC REPORTS   Vol. 7   2017.8

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    DOI: 10.1038/s41598-017-09115-2

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  149. Perioperative airway management of a 16-year-old boy with progressive airway obstruction due to juvenile nasopharyngeal angiofibroma

    Kamiyama Kei, Satomoto Maiko, Minami Kotaro, Baba Yukiko, Makita Koshi

    CLINICAL CASE REPORTS   Vol. 5 ( 8 ) page: 1274 - 1276   2017.8

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    DOI: 10.1002/ccr3.1056

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  150. Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure

    Matsue Y.

    Journal of the American College of Cardiology   Vol. 69 ( 25 ) page: 3042-3051   2017.6

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    DOI: 10.1016/j.jacc.2017.04.042

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  151. Stacking-cyclodextrin-microchip electrokinetic chromatographic determination of gabapentinoid drugs in pharmaceutical and biological matrices Reviewed

    Abdallah Zeid, Noritada Kaji, Jenny Jeehan Nasr,Fathalla Belal,Yoshinobu Baba, Mohamed Walash

    Journal of Chromatography A   Vol. 1503 ( 23 ) page: pp.65-75   2017.6

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    DOI: 10.1016/j.chroma.2017.04.049

  152. Nanostructures Integrated with a Nanochannel for Slowing Down DNA Translocation Velocity for Nanopore Sequencing Reviewed

    Xiaoyin SUN, Takao YASUI, Takeshi YANAGIDA, Noritada KAJI, Sakon RAHONG, Masaki KANAI, Kazuki NAGASHIMA, Tomoji KAWAI, Yoshinobu BABA

    Analytical Sciences   Vol. 33 ( 6 ) page: pp.75-738   2017.6

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    DOI: 0.2116/analsci.33.735

  153. Double-hydrophobic elastin-like polypeptides with added functional motifs: Self-assembly and cytocompatibility Reviewed

    Duc H. T. Le, Yoko Tsutsui, Ayae Sugawara-Narutaki, Hiroshi Yukawa, Yoshinobu Baba, Chikara Ohtsuki

    Journal of Biomedical Materials Research Part A     2017.6

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    DOI: 10.1002/jbm.a.36105

  154. Nanostructures Integrated with a Nanochannel for Slowing Down DNA Translocation Velocity for Nanopore Sequencing Reviewed

    Xiaoyin Sun, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Sakon Rahong, Masaki Kanai, Kazuki Nagashima, Tomoji Kawal, Yoshinobu Baba

    ANALYTICAL SCIENCES   Vol. 33 ( 6 ) page: 735 - 738   2017.6

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    Here, we developed a device integrated with a nanochannel and nanostructures to slow DNA translocation velocity. We found that translocation velocity of a single DNA molecule inside a nanochannel was decreased by pre-elongating it using some nanostructures, such as a shallow channel or nanopillars. This decrease of the translocation velocity was associated with the DNA mobility change, which is an intrinsic parameter of DNA molecules and unaffected by an electric field.

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  155. A millisecond micro-RNA separation technique by a hybrid structure of nanopillars and nanoslits Reviewed

    Qiong Wu, Noritada Kaji,Takao Yasui, Sakon Rahong, Takeshi Yanagida, Masaki Kanai, Kazuki Nagashima,Manabu Tokeshi,Tomoji Kawai, and Yoshinobu Baba

    Scientific Reports   Vol. 7   2017.3

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    DOI: 10.1038/srep43877

  156. A millisecond micro-RNA separation technique by a hybrid structure of nanopillars and nanoslits

    Wu Qiong, Kaji Noritada, Yasui Takao, Rahong Sakon, Yanagida Takeshi, Kanai Masaki, Nagashima Kazuki, Tokeshi Manabu, Kawai Tomoji, Baba Yoshinobu

    SCIENTIFIC REPORTS   Vol. 7   2017.3

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    DOI: 10.1038/srep43877

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  157. Transduction Function of a Magnetic Nanoparticle TMADM for Stem-Cell Imaging with Quantum Dots Reviewed

    Yusuke OGIHARA, Hiroshi YUKAWA, Daisuke ONOSHIMA, Yoshinobu BABA

    Analytical Sciences   Vol. 33 ( 2 ) page: pp.143-146   2017.2

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    DOI: 0.2116/analsci.33.143

  158. Forster Resonance Energy Transfer Mediated Photoluminescence Quenching in Stoichiometrically Assembled CdSe/ZnS Quantum Dot-Peptide Labeled Black Hole Quencher Conjugates for Matrix Metalloproteinase-2 Sensing Reviewed

    Sreenadh Sasidharan Pillavi, Hiroshi Yukawa, Daisuke Onoshima, Vasudevanpillai Biju, Yoshinobu Baba

    ANALYTICAL SCIENCES   Vol. 33 ( 2 ) page: 137 - 142   2017.2

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    The steady state and time-resolved photoluminescence quenching of streptavidin modified CdSe/ZnS quantum dots (QDs) instigated by biotin-peptide-BHQ-1 (biotin-pep-BHQ-1) molecule was investigated. Here, we have achieved an efficient photoluminescence (PL) quenching of QDs with the conjugation of dark quencher (black hole quencher-BHQ) molecules intermediated with the GPLGVRGK peptide. The luminescence of streptavidin-QDs585 was decreased upon titration with a nano molar concentration of the biotin-GPLGVRGK-BHQ-1 molecule. It has been suggested that the decrease of QDs PL occurred through a Forster resonance energy transfer (FRET) mechanism from the analysis of steady state photoluminescence intensity measurements as well as time resolved lifetime measurements of streptavidin-QDs and QDs(pep-BHQ-1)(n) conjugates. The sequence of intermediate peptide GPLG down arrow VRGK can act as a target material for matrix metalloproteinases-2 (MMP-2) produced by cancer cells at its Gly and Val region, shown by the down-headed arrow. Interestingly, here the reported self-assembled QDs-(pep-BHQ-1)(n) conjugates could detect the presence MMP-2 at a detection limit of 1 ng/mL with a clear luminescence recovery.

    DOI: 10.2116/analsci.33.137

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  159. Transduction Function of a Magnetic Nanoparticle TMADM for Stem-Cell Imaging with Quantum Dots Reviewed

    Yusuke Ogihara, Hiroshi Yukawa, Daisuke Onoshima, Yoshinobu Baba

    ANALYTICAL SCIENCES   Vol. 33 ( 2 ) page: 143 - 146   2017.2

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    We investigated the transduction function of a cationic dextran hydroxypropyltrimethyl ammonium chloride-coated magnetic iron oxide nanoparticle (TMADM-03) for transducing quantum dots (QDs) into adipose tissue-derived stem cells (ASCs). As a result, the fluorescence intensity of ASCs labeled with QDs using TMADM-03 was much higher than that of QDs only labeling. These data suggest that TMADM-03 can be useful as a transduction agent for QDs in stem-cell imaging.

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  160. In vivo fluorescence imaging and the diagnosis of stem cells using quantum dots for regenerative medicine Reviewed

    H. Yukawa, Y. Baba

    analytical chemistry   Vol. 89 ( 5 ) page: PP.2671-2681   2017.1

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    DOI: 10.1021/acs.analchem.6b04763

  161. Anhedonia and its correlation with clinical aspects in Parkinson's disease

    Nagayama H.

    Journal of the Neurological Sciences   Vol. 372   page: 403-407   2017.1

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    DOI: 10.1016/j.jns.2016.10.051

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  162. NIR-II近赤外領域における移植幹細胞in vivo蛍光イメージング Reviewed

    湯川博、小林香央里、新岡宏彦、亀山達矢、佐藤和秀、鳥本司、石川哲也、馬場嘉信

    バイオインダストリー   Vol. 34   page: pp.27-34   2017.1

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  163. Immunomodulatory effects of adipose tissue-derived stem cells on concanavalin A-induced acute liver injury in mice Reviewed

    Yoshizumi Y., Yukawa H*., Iwaki R., Fujinaka S., Kanou A., Kanou Y., Yamada T., Nakagawa S., Ohara T., Nakagiri K., Ogihara Y., Tsutsui Y., Hayashi Y., Ishigami M., Baba Y., Ishikawa T.

    Cell Medicine   Vol. 91 ( 1-2 ) page: pp.21-23   2017.1

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  164. Immunomodulatory effects of adipose tissue-derived stem cells on concanavalin A-induced acute liver injury in mice Reviewed

    Yoshizumi Y, Yukawa H, Iwaki R, Fujinaka S, Kanou A, Kanou Y, Yamada T, Nakagawa S, Ohara T, Nakagiri K, Ogihara Y, Tsutsui Y, Hayashi Y, Ishigami M, Baba Y, Ishikawa T

    Cell Medicine   Vol. 91 ( 1-2 ) page: pp.21-23   2017.1

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  165. Labeling and in vivo Visualization of Transplanted Adipose Tissue-Derived Stem Cells with Safe Cadmium-Free Aqueous ZnS coating of ZnS-AgInS2 Nanoparticles Reviewed

    .Y. Ogihara, H. Yukawa, T. Kameyama, H. Nishi, D. Onoshima, T. Ishikawa, T. Torimoto, Y. Baba

    Scientific Reports   Vol. 7   2017.1

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    DOI: 10.1038/srep40047

  166. Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles

    Ogihara Yusuke, Yukawa Hiroshi, Kameyama Tatsuya, Nishi Hiroyasu, Onoshima Daisuke, Ishikawa Tetsuya, Torimoto Tsukasa, Baba Yoshinobu

    SCIENTIFIC REPORTS   Vol. 7   2017.1

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    DOI: 10.1038/srep40047

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  167. DDSとナノテクノロジーがもたらす超スマート社会 Reviewed

    馬場嘉信

    DDS学会誌   Vol. 32 ( 1 ) page: 8   2017.1

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    DOI: 10.2745/dds.32.8

  168. Nanowires modeled after physical defense mechanism of cicada wing

      Vol. 52 ( 1 ) page: 35 - 37   2017.1

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  169. Effect of DNA Methylation on the Velocity of DNA Translocation through a Nanochannel. Reviewed

    Xiaoyin Sun, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Sakon Rahong, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 33 ( 6 ) page: 727 - 730   2017

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    Here, we report the effect of DNA methylation on the velocity of DNA translocation through a nanochannel, as determined by measuring differences in translocation velocities between methylated and non-methylated DNA molecules. We found that the velocity of translocation of methylated DNA was faster than that of non-methylated DNA, which we attributed to variation in the coefficients of diffusion and friction with the nanochannel wall, due to the increased molecular weight and stiffness, respectively, of methylated DNA.

    DOI: 10.2116/analsci.33.727

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  170. A Single Bacterium and Mammalian Cell Analysis by Ionic Current Measurements in a Microchannel

    Kaji N., Sano M., Ito S., Yasaki H., Yasui T., Yukawal H., Baba Y.

    2017 IEEE INTERNATIONAL ELECTRON DEVICES MEETING (IEDM)     page: .   2017

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  171. Fabrication and Evaluation of Microfluidic Immunoassay Devices with Antibody-Immobilized Microbeads Retained in Porous Hydrogel Micropillars

    Kasama Toshihiro, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    MICROCHIP DIAGNOSTICS: METHODS AND PROTOCOLS   Vol. 1547   page: 49-56   2017

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    DOI: 10.1007/978-1-4939-6734-6_4

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  172. Microfluidic DNA Stretching Device for Single-Molecule Diagnostics

    Onoshima Daisuke, Baba Yoshinobu

    MICROCHIP DIAGNOSTICS: METHODS AND PROTOCOLS   Vol. 1547   page: 105-111   2017

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    DOI: 10.1007/978-1-4939-6734-6_8

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  173. Nanostructures Integrated with a Nanochannel for Slowing Down DNA Translocation Velocity for Nanopore Sequencing. Reviewed

    Xiaoyin Sun, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Sakon Rahong, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 33 ( 6 ) page: 735 - 738   2017

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    Here, we developed a device integrated with a nanochannel and nanostructures to slow DNA translocation velocity. We found that translocation velocity of a single DNA molecule inside a nanochannel was decreased by pre-elongating it using some nanostructures, such as a shallow channel or nanopillars. This decrease of the translocation velocity was associated with the DNA mobility change, which is an intrinsic parameter of DNA molecules and unaffected by an electric field.

    DOI: 10.2116/analsci.33.735

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  174. Transduction Function of a Magnetic Nanoparticle TMADM for Stem-Cell Imaging with Quantum Dots. Reviewed

    Yusuke Ogihara, Hiroshi Yukawa, Daisuke Onoshima, Yoshinobu Baba

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 33 ( 2 ) page: 143 - 146   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    We investigated the transduction function of a cationic dextran hydroxypropyltrimethyl ammonium chloride-coated magnetic iron oxide nanoparticle (TMADM-03) for transducing quantum dots (QDs) into adipose tissue-derived stem cells (ASCs). As a result, the fluorescence intensity of ASCs labeled with QDs using TMADM-03 was much higher than that of QDs only labeling. These data suggest that TMADM-03 can be useful as a transduction agent for QDs in stem-cell imaging.

    DOI: 10.2116/analsci.33.143

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  175. Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis

    Kaji N.

    RSC Nanoscience and Nanotechnology   Vol. 2017-January ( 41 ) page: 76-98   2017

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    DOI: 10.1039/9781849735230-00076

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  176. The activated conformation of integrin β7 is a novel multiple myeloma-specific target for CAR T cell therapy

      Vol. 23 ( 12 ) page: 1436-1443   2017

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    DOI: 10.1038/nm.4431

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  177. <i>In vivo</i> fluorescence imaging of transplanted stem cells labeled with quantum dots

    Yukawa Hiroshi, baba Yoshinobu

    Organ Biology   Vol. 24 ( 2 ) page: 201 - 206   2017

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    Quantum dots (QDs) have excellent fluorescence properties in comparison to traditional fluorescence probes. Thus, the optical application of QDs is in rapid expansion to each field of analytical chemistry. In this paper, we described about the application of QDs to regenerative medicine, especially stem cell transplantation therapy. Specifically, labeling technologies of stem cells by QDs composed of semiconductor materials in combination with poly-cationic liposome (Lipofectamine<sup>&reg;</sup>) or cell penetrating peptide (octa-arginine) were reviewed. Moreover, <i>in vivo</i> imaging of transplanted stem cells in mice by QDs emitting fluorescence in near-infrared region, which could be detected by fluorescence <i>in vivo</i> imaging machines such as IVIS imaging system, was reported.

    DOI: 10.11378/organbio.24.201

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  178. A Single Bacterium and Mammalian Cell Analysis by Ionic Current Measurements in a Microchannel

    Kaji N, Sano M, Ito S, Yasaki H, Yasui T, Yukawal H, Baba Y

    2017 IEEE INTERNATIONAL ELECTRON DEVICES MEETING (IEDM)     page: .   2017

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  179. セミの翅の物理的防御機構を模倣したナノワイヤ構造体の創製 Reviewed

    安井隆雄, 米勢明弘, 加地範匡, 柳田剛, 川合知二, 馬場嘉信

    昆虫と自然   Vol. 52   page: pp.35-37   2016.12

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  180. Microfluidic Transport Through Microsized Holes Treated by Nonequilibrium Atmospheric-Pressure Plasma Reviewed International journal

    Takumi Ito, Kenji Ishikawa, Daisuke Onoshima, Naoto Kihara, Kentaro Tatsukoshi, Hidefumi Odaka, Hiroshi Hashizume, Hiromasa Tanaka, Hiroshi Yukawa, Keigo Takeda, Hiroki Kondo, Makoto Sekine, Yoshinobu Baba, Masaru Hori

    IEEE Transactions on Plasma Science   Vol. 44 ( 12 ) page: 3060 - 3065   2016.12

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    © 1973-2012 IEEE. In the field of microfluidics, it is possible to facilitate liquid transport through microsized holes with large slip lengths by lowering the friction at the interface between the flow and the inner surface of the holes. In this paper, we discuss the use of nonequilibrium atmospheric-pressure plasma to modify the surface wettability of microsized holes in glass substrates that are similar to those used as flow channels in glass microfiltration devices. In our experiments, liquid transport flows were driven by internal Laplace pressure differences based on the surface tensions of droplets placed on the front and back sides of the tested substrates.

    DOI: 10.1109/TPS.2016.2571721

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  181. Identifying DNA methylation in a nanochannel Reviewed

    X. Sun, T. Yasui, T. Yanagida, N. Kaji, S. Rahong, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Sci. Technol. Adv. Mater.   Vol. 17 ( 1 ) page: pp.644-649   2016.10

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  182. MICROFLUIDIC LONG-PORE-CHANNEL TO HIGHLIGHT BACTERIA CONTENTS Reviewed

    H. Yasaki, T. Yasui1,2, T. Yanagida, N. Kaji, M. Kanai, M. Fukuyama, K. Nagashima, T. Kawai, and Y. Baba

    Micro Total Analysis Systems 2016     page: 100-101   2016.10

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  183. WATER FILM DEVICE FOR CONTINUOUS PARTICULATE MATTER COLLECTION Reviewed

    T. Shimada, T. Yasui, A. Hibara, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, and Y. Baba

    Micro Total Analysis Systems 2016     page: 1473-1474   2016.10

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  184. A HIGH-SENSITIVITY CYCLODEXTRIN-MICROCHIP ELECTROPHORESIS SIMULTANEOUS ANALYSIS OF GABAPENTIN AND PREGABALIN Reviewed

    A.M. Zeid, J. Nasr, N. Kaji, F.F. Belal, M.I. Walash, and Y. Baba

    Micro Total Analysis Systems 2016     page: 1457-1458   2016.10

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  185. EFFECTS OF THE GROOVED STRUCTURES AND THE ETHANOL CONCENTRATION ON THE SMALL-SIZED LIPID NANOPARTICLES FORMATION Reviewed

    Y. Fujishima, M. Maeki, Y. Sato, T. Yasui, A. Ishida, H. Tani, Y. Baba, H. Harashima, and M. Tokeshi

    Micro Total Analysis Systems 2016     page: 1412-1413   2016.10

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  186. SIMULTANEOUS IONIC CURRENT AND OPTICAL DETECTION OF FINE PARTICULATE MATTERS (PM2.5) BASED ON CROSS-JUNCTION MICROFLUIDIC DEVICE Reviewed

    S. Rahong, T. Yasui, H. Yasaki, T. Yanagida, M. Kanai, K. Nagashima, N. Kaji, T. Kawai and Y. Baba

    Micro Total Analysis Systems 2016     page: 1284-1285   2016.10

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  187. SELF-ASSEMBLED MONOLAYER AND PEPTIDE COATED NANOWIRE DEVICES FOR SELECTIVE DETECTION OF C-REACTIVE PROTEIN AND E.COLI WITHOUT ANTIBODY Reviewed

    A. Yokoyama, T. Yasui, T. Goda, T. Yanagida, M. Tanaka, M. Muto, M. Okochi, N. Kaji, M. Kanai, K. Nagashima, Y. Miyahara, T. Kawai and Y. Baba

    Micro Total Analysis Systems 2016     page: 816-817   2016.10

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  188. RECOGNITION MICROPORES FOR DETECTING SINGLE-BACTERIA Reviewed

    M. Tsutsui, K. Yokota, T. Yasui, H. Yasaki, M. Okochi, M. Taniguchi, T. Washio, Y. Baba, and T. Kawai

    Micro Total Analysis Systems 2016     page: 679-680   2016.10

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  189. MASSIVELY PARALLEL SINGLE NUCLEI ASSAY ON MICROCHAMBER ARRAY DEVICES Reviewed

    S. Ito, N. Kaji, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2016     page: 651-652   2016.10

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  190. MILLISECOND MEASUREMENT OF SINGLE CELL SIZE AND DEFORMABILITY BY ELECTRICAL DETECTION IN MICROFLUIDIC DEVICE WITH TWO CONSECUTIVE CONSTRICTIONS Reviewed

    N. Kaji, M. Sano, H. Yasaki, T. Yasui, and Y. Baba

    Micro Total Analysis Systems 2016     page: 341-342   2016.10

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  191. MICRO SAND TIMER IN GLASS MEMBRANE DEVICE SEPARATES SINGLE CIRCULATING TUMOR CELLS IN BLOOD Reviewed

    D. Kuboyama, D. Onoshima, H. Yukawa, M. Tanaka, K. Ishikawa4, M. Hori1, and Y. Baba

    Micro Total Analysis Systems 2016     page: 297-298   2016.10

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  192. NANOWIRES FOR EARLY CANCER AND DIABETES DIAGNOSIS VIA MICRO-RNA DETECTION IN URINE EXTRACELLULAR VESICLES Reviewed

    T. Yasui, D. Takeshita, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, H. Yukawa1, T. Kawai, and Y. Baba

    Micro Total Analysis Systems 2016     page: 108-109   2016.10

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  193. IMMUNO-WALL LAB-ON-A-CHIP PROTEIN ANALYSIS DEVICES FOR HIGH PRECISION SURGERY OF GLIOMAS Reviewed

    T. Kasama, , A. Yamamichi, F. Ohka, Y. Kato, H. Suzuki, A. Kato, K. Motomura, M. Hirano, M. Ranjit, L. Chalise, M. Kurimoto, G. Kondo, K. Aoki, N. Kaji, T. Matsubara, H. Suzuki, M. Tokeshi, T. Wakabayashi, A. Natsume, and Y. Baba

    Micro Total Analysis Systems 2016     page: pp.651-652   2016.10

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  194. A HIGH-SENSITIVITY CYCLODEXTRIN-MICROCHIP ELECTROPHORESIS SIMULTANEOUS ANALYSIS OF GABAPENTIN AND PREGABALIN Reviewed

    A.M. Zeid, J. Nasr, N. Kaji, F.F. Belal, M.I. Walash, Y. Baba

    Micro Total Analysis Systems 2016     page: 1457-1458   2016.10

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  195. MILLISECOND MEASUREMENT OF SINGLE CELL SIZE AND DEFORMABILITY BY ELECTRICAL DETECTION IN MICROFLUIDIC DEVICE WITH TWO CONSECUTIVE CONSTRICTIONS Reviewed

    N. Kaji, M. Sano, H. Yasaki, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2016     page: 341-342   2016.10

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  196. MICROFLUIDIC LONG-PORE-CHANNEL TO HIGHLIGHT BACTERIA CONTENTS Reviewed

    H. Yasaki, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, M. Fukuyama, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2016     page: 100-101   2016.10

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  197. MASSIVELY PARALLEL SINGLE NUCLEI ASSAY ON MICROCHAMBER ARRAY DEVICES Reviewed

    S. Ito, N. Kaji, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2016     page: 651-652   2016.10

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  198. IMMUNO-WALL LAB-ON-A-CHIP PROTEIN ANALYSIS DEVICES FOR HIGH PRECISION SURGERY OF GLIOMAS Reviewed

    T. Kasama, A. Yamamichi, F. Ohka, Y. Kato, H. Suzuki, A. Kato, K. Motomura, M. Hirano, M. Ranjit, L. Chalise, M. Kurimoto, G. Kondo, K. Aoki, N. Kaji, T. Matsubara, H. Suzuki, M. Tokeshi, T. Wakabayashi, A. Natsume, Y. Baba

    Micro Total Analysis Systems 2016     page: pp.651-652   2016.10

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  199. EFFECTS OF THE GROOVED STRUCTURES AND THE ETHANOL CONCENTRATION ON THE SMALL-SIZED LIPID NANOPARTICLES FORMATION Reviewed

    Y. Fujishima, M. Maeki, Y. Sato, T. Yasui, A. Ishida, H. Tani, Y. Baba, H. Harashima, M. Tokeshi

    Micro Total Analysis Systems 2016     page: 1412-1413   2016.10

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  200. NANOWIRES FOR EARLY CANCER AND DIABETES DIAGNOSIS VIA MICRO-RNA DETECTION IN URINE EXTRACELLULAR VESICLES Reviewed

    T. Yasui, D. Takeshita, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, H. Yukawa, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2016     page: 108-109   2016.10

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  201. WATER FILM DEVICE FOR CONTINUOUS PARTICULATE MATTER COLLECTION Reviewed

    T. Shimada, T. Yasui, A. Hibara, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2016     page: 1473-1474   2016.10

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  202. SIMULTANEOUS IONIC CURRENT AND OPTICAL DETECTION OF FINE PARTICULATE MATTERS (PM2.5) BASED ON CROSS-JUNCTION MICROFLUIDIC DEVICE Reviewed

    S. Rahong, T. Yasui, H. Yasaki, T. Yanagida, M. Kanai, K. Nagashima, N. Kaji, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2016     page: 1284-1285   2016.10

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  203. SELF-ASSEMBLED MONOLAYER AND PEPTIDE COATED NANOWIRE DEVICES FOR SELECTIVE DETECTION OF C-REACTIVE PROTEIN AND E.COLI WITHOUT ANTIBODY Reviewed

    A. Yokoyama, T. Yasui, T. Goda, T. Yanagida, M. Tanaka, M. Muto, M. Okochi, N. Kaji, M. Kanai, K. Nagashima, Y. Miyahara, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2016     page: 816-817   2016.10

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  204. RECOGNITION MICROPORES FOR DETECTING SINGLE-BACTERIA Reviewed

    M. Tsutsui, K. Yokota, T. Yasui, H. Yasaki, M. Okochi, M. Taniguchi, T. Washio, Y. Baba, T. Kawai

    Micro Total Analysis Systems 2016     page: 679-680   2016.10

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  205. An immuno-wall microdevice exhibits rapid and sensitive detection of IDH1-R132H mutation specific to grade II and III gliomas Reviewed

    Yamamichi, Akane; Kasama, Toshihiro; Ohka, Fumiharu; Suzuki, Hiromichi; Kato, Akira; Motomura, Kazuya; Hirano, Masaki; Ranjit, Melissa; Chalise, Lushun; Kurimoto, Michihiro; Kondo, Goro; Aoki, Kosuke; Kaji, Noritada; Tokeshi, Manabu; Matsubara, Toshio; Senga, Takeshi; Kaneko, Mika. K; Suzuki, Hidenori; Hara, Masahito; Wakabayashi, Toshihiko; Baba, Yoshinobu; Kato, Yukinari; Natsume, Atsushi

    Science and Technology of Advanced Materials   Vol. 17 ( 1 ) page: pp.618-625   2016.10

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  206. 量子ドットによる移植幹細胞の生体内イメージング Reviewed

    湯川 博, 馬場嘉信

    光学   Vol. 45 ( 10 ) page: pp.386-391   2016.10

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  207. In vivo Imaging of Transplanted Stem Cells by Using Quantum Dots

      Vol. 45 ( 10 ) page: 386 - 391   2016.10

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  208. Measurement of DNA length changes upon CpG hypermethylation by microfluidic molecular stretching Reviewed

    Onoshima D*., Kawakita N., Takeshita D., Niioka H., Yukawa H., Miyake J., Baba Y.

    Cell Medicine   Vol. 91 ( 6 ) page: pp.61-66   2016.9

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  209. Measurement of DNA length changes upon CpG hypermethylation by microfluidic molecular stretching Reviewed

    Onoshima D, Kawakita N, Takeshita D, Niioka H, Yukawa H, Miyake J, Baba Y

    Cell Medicine   Vol. 91 ( 6 ) page: pp.61-66   2016.9

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  210. Multispectral Emissions of Lanthanide-Doped Gadolinium Oxide Nanophosphors for Cathodoluminescence and Near-Infrared Upconversion/Downconversion Imaging. Reviewed International journal

    Doan Thi Kim Dung, Shoichiro Fukushima, Taichi Furukawa, Hirohiko Niioka, Takumi Sannomiya, Kaori Kobayashi, Hiroshi Yukawa, Yoshinobu Baba, Mamoru Hashimoto, Jun Miyake

    Nanomaterials (Basel, Switzerland)   Vol. 6 ( 9 ) page: 163   2016.9

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    Comprehensive imaging of a biological individual can be achieved by utilizing the variation in spatial resolution, the scale of cathodoluminescence (CL), and near-infrared (NIR), as favored by imaging probe Gd₂O₃ co-doped lanthanide nanophosphors (NPPs). A series of Gd₂O₃:Ln3+/Yb3+ (Ln3+: Tm3+, Ho3+, Er3+) NPPs with multispectral emission are prepared by the sol-gel method. The NPPs show a wide range of emissions spanning from the visible to the NIR region under 980 nm excitation. The dependence of the upconverting (UC)/downconverting (DC) emission intensity on the dopant ratio is investigated. The optimum ratios of dopants obtained for emissions in the NIR regions at 810 nm, 1200 nm, and 1530 nm are applied to produce nanoparticles by the homogeneous precipitation (HP) method. The nanoparticles produced from the HP method are used to investigate the dual NIR and CL imaging modalities. The results indicate the possibility of using Gd₂O₃ co-doped Ln3+/Yb3+ (Ln3+: Tm3+, Ho3+, Er3+) in correlation with NIR and CL imaging. The use of Gd₂O₃ promises an extension of the object dimension to the whole-body level by employing magnetic resonance imaging (MRI).

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  211. Anomalous separation of small y-chromosomal DNA fragments on microchip electrophoresis Reviewed

    Mohammad Jabasini, Ashraf Ewis, Youichi Sato, Yutaka Nakahori, Yoshinobu Baba

    Scientia Pharmaceutica   Vol. 84 ( 3 ) page: 507 - 513   2016.9

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    © 2016 by the authors; licensee MDPI, Basel, Switzerland. We investigated an anomalous DNA separation where two DNA fragments from the human Y-chromosome sY638 (64 bp) and sY592 (65 bp), with only one base pair difference, were separated. This result is abnormal since in a previous study, we found that 5 bp was the minimum difference between two DNA fragments that the microchip electrophoresis system can separate. The formation of a mini-loop in the structure of the DNA fragment of sY638 (64 bp) was strongly expected to be the reason. To investigate this, we synthesized three modified DNA fragments for sY638 (64 bp), and the modifications were in two expected locations for possible mini-loop formation. Later, the separation between sY592 (65 bp) and the three modified fragments of sY638 (64 bp) was not possible. Thus, we conclude that the formation of a mini-loop in the structure of the DNA is the reason behind this anomalous separation.

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  212. セミの翅の物理的防御機構を模倣したナノワイヤ構造体の創製 Reviewed

    安井隆雄, 米勢明弘, 加地範匡, 柳田剛, 川合知二, 馬場嘉信

    昆虫と自然   Vol. 51 ( 9 ) page: pp.39-41   2016.8

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  213. Label-free detection of real-time DNA amplification using a nanofluidic diffraction grating Reviewed International journal

    Takao Yasui, Kensuke Ogawa, Noritada Kaji, Mats Nilsson, Taiga Ajiri, Manabu Tokeshi, Yasuhiro Horiike, Yoshinobu Baba

    SCIENTIFIC REPORTS   Vol. 6   page: 31642 - 31642   2016.8

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    Quantitative DNA amplification using fluorescence labeling has played an important role in the recent, rapid progress of basic medical and molecular biological research. Here we report a label-free detection of real-time DNA amplification using a nanofluidic diffraction grating. Our detection system observed intensity changes during DNA amplification of diffracted light derived from the passage of a laser beam through nanochannels embedded in a microchannel. Numerical simulations revealed that the diffracted light intensity change in the nanofluidic diffraction grating was attributed to the change of refractive index. We showed the first case reported to date for label-free detection of real-time DNA amplification, such as specific DNA sequences from tubercle bacilli (TB) and human papillomavirus (HPV). Since our developed system allows quantification of the initial concentration of amplified DNA molecules ranging from 1 fM to 1 pM, we expect that it will offer a new strategy for developing fundamental techniques of medical applications.

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  214. Nanowires modeled after physical defense mechanism of cicada wing

      Vol. 51 ( 9 ) page: 39 - 41   2016.8

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  215. Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment International journal

    Takao Yasui, Jumpei Morikawa, Noritada Kaji, Manabu Tokeshi, Kazuo Tsubota, Yoshinobu Baba

    MICROMACHINES   Vol. 7 ( 7 ) page: 113 - 113   2016.7

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    Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 mu m microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.

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  216. Application of a cell microarray chip system for accurate, highly sensitive, and rapid diagnosis for malaria in Uganda Reviewed International journal

    Shouki Yatsushiro, Takeki Yamamoto, Shohei Yamamura, Kaori Abe, Eriko Obana, Takahiro Nogami, Takuya Hayashi, Takashi Sesei, Hiroaki Oka, Joseph Okello-Onen, Emmanuel I. Odongo-Aginya, Mary Auma Alai, Alex Olia, Dennis Anywar, Miki Sakurai, Nirianne M. Q. Palacpac, Toshihiro Mita, Toshihiro Horii, Yoshinobu Baba, Masatoshi Kataoka

    SCIENTIFIC REPORTS   Vol. 6   page: 30136 - 30136   2016.7

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    Accurate, sensitive, rapid, and easy operative diagnosis is necessary to prevent the spread of malaria. A cell microarray chip system including a push column for the recovery of erythrocytes and a fluorescence detector was employed for malaria diagnosis in Uganda. The chip with 20,944 microchambers (105 mu m width and 50 mu m depth) was made of polystyrene. For the analysis, 6 mu l of whole blood was employed, and leukocytes were practically removed by filtration through SiO2-nano-fibers in a column. Regular formation of an erythrocyte monolayer in each microchamber was observed following dispersion of an erythrocyte suspension in a nuclear staining dye, SYTO 21, onto the chip surface and washing. About 500,000 erythrocytes were analyzed in a total of 4675 microchambers, and malaria parasite-infected erythrocytes could be detected in 5 min by using the fluorescence detector. The percentage of infected erythrocytes in each of 41 patients was determined. Accurate and quantitative detection of the parasites could be performed. A good correlation between examinations via optical microscopy and by our chip system was demonstrated over the parasitemia range of 0.0039-2.3438% by linear regression analysis (R-2 = 0.9945). Thus, we showed the potential of this chip system for the diagnosis of malaria.

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  217. The immunosuppressive effect via HGF-CMET pathway of autologous adipose tissue-derived mesenchymal stem cells in a rat lung transplantation model

    Watanabe Hironosuke, Tsuchiya Tomoshi, Yamasaki Naoya, Miyazaki Takuro, Matsumoto Keitaro, Yukawa Hiroshi, Baba Yoshinobu, Nagayasu Takeshi

    TRANSPLANTATION   Vol. 100 ( 7 ) page: S107-S108   2016.7

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  218. The immunosuppressive effect via HGF-CMET pathway of autologous adipose tissue-derived mesenchymal stem cells in a rat lung transplantation model Reviewed

    Watanabe Hironosuke, Tsuchiya Tomoshi, Yamasaki Naoya, Miyazaki Takuro, Matsumoto Keitaro, Yukawa Hiroshi, Baba Yoshinobu, Nagayasu Takeshi

    TRANSPLANTATION   Vol. 100 ( 7 ) page: S107 - S108   2016.7

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  219. Microfluidic transport through microsized holes treated by non-equilibrium atmospheric-pressure plasma Reviewed

    T. Ito, K. Ishikawa, D. Onoshima, N. Kihara, K. Tatsukoshi, H. Odaka, H. Hashizume, H. Tanaka, H. Yukawa, K. Takeda, H. Kondo, M. Sekine, Y. Baba, and M. Hori

    IEEE Trans. Plasma Sci   Vol. 44   page: pp.3060-3065   2016.6

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  220. A Japanese multicenter survey characterizing pain in Parkinson's disease

    Kubo S.I.

    Journal of the Neurological Sciences   Vol. 365   page: 162-166   2016.6

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    DOI: 10.1016/j.jns.2016.04.015

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  221. Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery Reviewed

    Yusuke Sato, Yusuke Note, Masatoshi Maeki, Noritada Kaji, Yoshinobu Baba, Manabu Tokeshi, Hideyoshi Harashima

    Journal of Controlled Release   Vol. 229   page: 48-57   2016.5

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  222. Three-dimensional fabrication for microfluidics by conventional techniques and equipment used in mass production Reviewed

    Toyohiro Naito, Makoto Nakamura, Noritada Kaji, Takuya Kubo, Yoshinobu Baba, Koji Otsuka

    Micromachines   Vol. 7 ( 5 ) page: 82   2016.5

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  223. Correlative near-infrared light and cathodoluminescence microscopy using Y2O3:Ln, Yb (Ln = Tm, Er) nanophosphors for multiscale, multicolour bioimaging Reviewed

    S. Fukushima, T. Furukawa, H. Niioka, M. Ichimiya, T. Sannomiya, N. Tanaka, D. Onoshima, H. Yukawa, Y. Baba, M. Ashida, J. Miyake, T. Araki, M. Hashimoto

    SCIENTIFIC REPORTS   Vol. 6   2016.5

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    This paper presents a new correlative bioimaging technique using Y2O3:Tm, Yb and Y2O3:Er, Yb nanophosphors (NPs) as imaging probes that emit luminescence excited by both near-infrared (NIR) light and an electron beam. Under 980 nm NIR light irradiation, the Y2O3:Tm, Yb and Y2O3:Er, Yb NPs emitted NIR luminescence (NIRL) around 810 nm and 1530 nm, respectively, and cathodoluminescence at 455 nm and 660 nm under excitation of accelerated electrons, respectively. Multimodalities of the NPs were confirmed in correlative NIRL/CL imaging and their locations were visualized at the same observation area in both NIRL and CL images. Using CL microscopy, the NPs were visualized at the single-particle level and with multicolour. Multiscale NIRL/CL bioimaging was demonstrated through in vivo and in vitro NIRL deep-tissue observations, cellular NIRL imaging, and high-spatial resolution CL imaging of the NPs inside cells. The location of a cell sheet transplanted onto the back muscle fascia of a hairy rat was visualized through NIRL imaging of the Y2O3:Er, Yb NPs. Accurate positions of cells through the thickness (1.5 mm) of a tissue phantom were detected by NIRL from the Y2O3:Tm, Yb NPs. Further, locations of the two types of NPs inside cells were observed using CL microscopy.

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  224. Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery Reviewed International journal

    Yusuke Sato, Yusuke Note, Masatoshi Maeki, Noritada Kaji, Yoshinobu Baba, Manabu Tokeshi, Hideyoshi Harashima

    JOURNAL OF CONTROLLED RELEASE   Vol. 229   page: 48 - 57   2016.5

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    Because nanoparticles with diameters less than 50 nm penetrate stromal-rich tumor tissues more efficiently, the synthesis of small-sized nanoparticles encapsulating short interfering RNA (siRNA) is important in terms of realizing novel siRNA medicine for the treatment of various cancers. Lipid nanoparticles (LNPs) are the leading systems for the delivery of siRNA in vivo. Limit size LNPs were successfully synthesized using a microfluidic mixing technique. However, the physicochemical properties and potential for in vivo siRNA delivery of the limit-size LNPs have not been examined in detail. In the present study, we prepared LNPs with different diameters from 32 to 67 nm using a microfluidic mixing devise and examined the physicochemical properties of the particles and the potential for their use in delivering siRNA in vitro and in vivo to liver. Reducing the size of the LNPs causes poor-packing and an increased surface area, which result in their instability in serum. Moreover, it was revealed that the ability of endosomal escape (cytosolic siRNA release) of the smaller LNPs is subject to inhibition by serum compared to that of larger counterparts. Taken together, an increase in packing and avoiding the adsorption of serum components are key strategies for the development of next-generation highly potent and small-sized LNPs. (C) 2016 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jconrel.2016.03.019

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  225. Recent developments of nanowires for bio-applications from molecular to cellular levels Reviewed

    S. Rahong, T. Yasui, N. Kaji, Y. Baba

    Lab on a Chip   Vol. 16   page: 1126-1138   2016.4

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  226. Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

    Ohmi Yuhsuke, Ise Wataru, Harazono Akira, Takakura Daisuke, Fukuyama Hidehiro, Baba Yoshihiro, Narazaki Masashi, Shoda Hirofumi, Takahashi Nobunori, Ohkawa Yuki, Ji Shuting, Sugiyama Fumihiro, Fujio Keishi, Kumanogoh Atsushi, Yamamoto Kazuhiko, Kawasaki Nana, Kurosaki Tomohiro, Takahashi Yoshimasa, Furukawa Koichi

    NATURE COMMUNICATIONS   Vol. 7   2016.4

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    DOI: 10.1038/ncomms11205

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  227. Recent developments in nanowires for bio-applications from molecular to cellular levels Reviewed International journal

    Sakon Rahong, Takao Yasui, Noritada Kaji, Yoshinobu Baba

    Lab on a Chip   Vol. 16 ( 7 ) page: 1126 - 1138   2016.4

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    © The Royal Society of Chemistry 2016. This review highlights the most promising applications of nanowires for bioanalytical chemistry and medical diagnostics. The materials discussed here are metal oxide and Si semiconductors, which are integrated with various microfluidic systems. Nanowire structures offer desirable advantages such as a very small diameter size with a high aspect ratio and a high surface-to-volume ratio without grain boundaries; consequently, nanowires are promising tools to study biological systems. This review starts with the integration of nanowire structures into microfluidic systems, followed by the discussion of the advantages of nanowire structures in the separation, manipulation and purification of biomolecules (DNA, RNA and proteins). Next, some representative nanowire devices are introduced for biosensors from molecular to cellular levels based on electrical and optical approaches. Finally, we conclude the review by highlighting some bio-applications for nanowires and presenting the next challenges that must be overcome to improve the capabilities of nanowire structures for biological and medical systems.

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  228. Crystal Phase-Controlled Synthesis of Rod-Shaped AgInTe2 Nanocrystals for in vivo Imaging in the Near-Infrared Wavelength Region Reviewed

    Kameyama, Tatsuya; Ishigami, Yujiro; Yukawa, Hiroshi; Shimada, Taisuke; Baba, Yoshinobu; Ishikawa, Tetsuya; Kuwabata, Susumu; Torimoto, Tsukasa

    Nanoscale   Vol. 8   page: 5435-5440   2016.2

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  229. Functional Double-Shelled Silicon Nanocrystals for Two-Photon Fluorescence Cell Imaging: Spectral Evolution and Tuning Reviewed

    Sourov Chandra, Batu Ghosh, Grory Beaune, Usharani Nagarajan, Takao Yasui, Jin Nakamura, Tohru Tsuruoka, Yoshinobu Baba, Naoto Shirahata, Francoise M. Winnik

    Nanoscale   Vol. 8   page: 9009-9019   2016.2

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    DOI: 10.1039/C6NR01437B

  230. Determination of six anti-Parkinson drugs using cyclodextrin-capillary electrophoresis method: application to pharmaceutical dosage forms Reviewed

    Abdallah M. Zeid*ab, Jenny Jeehan M. Nasrb, Fathalla F. Belalb, Shinya Kitagawac, Noritada Kajiade, Yoshinobu Babaadfg and Mohamed I. Walashb

    RSC Advances   Vol. 6 ( 21 ) page: pp.17519-17530   2016.2

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  231. 移植幹細胞in vivo蛍光イメージングが再生医療創薬に果たす役割 Reviewed

    湯川博、馬場嘉信

    DDS学会誌   Vol. 31   page: 135-145   2016.1

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  232. Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice

    Yoshizumi Yasuma, Yukawa Hiroshi, Iwaki Ryoji, Fujinaka Sanae, Kanou Ayano, Kanou Yuki, Yamada Tatsuya, Nakagawa Shingo, Ohara Tomomi, Nakagiri Kenta, Ogihara Yusuke, Tsutsui Yoko, Hayashi Yumi, Ishigami Masatoshi, Baba Yoshinobu, Ishikawa Tetsuya

    CELL MEDICINE   Vol. 9 ( 1-2 ) page: 21-33   2016.1

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  233. Measurement of DNA Length Changes Upon CpG Hypermethylation by Microfluidic Molecular Stretching

    Onoshima Daisuke, Kawakita Naoko, Takeshita Daiki, Niioka Hirohiko, Yukawa Hiroshi, Miyake Jun, Baba Yoshinobu

    CELL MEDICINE   Vol. 9 ( 1-2 ) page: 61-66   2016.1

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  234. An immuno-wall microdevice exhibits rapid and sensitive detection of IDH1-R132H mutation specific to grade II and III gliomas Reviewed

    Akane Yamamichi, Toshihiro Kasama, Fumiharu Ohka, Hiromichi Suzuki, Akira Kato, Kazuya Motomura, Masaki Hirano, Melissa Ranjit, Lushun Chalise, Michihiro Kurimoto, Goro Kondo, Kosuke Aoki, Noritada Kaji, Manabu Tokeshi, Toshio Matsubara, Takeshi Senga, Mika K. Kaneko, Hidenori Suzuki, Masahito Hara, Toshihiko Wakabayashi, Yoshinobu Baba, Yukinari Kato, Atsushi Natsume

    SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS   Vol. 17 ( 1 ) page: 618 - 625   2016

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    World Health Organization grade II and III gliomas most frequently occur in the central nervous system (CNS) in adults. Gliomas are not circumscribed; tumor edges are irregular and consist of tumor cells, normal brain tissue, and hyperplastic reactive glial cells. Therefore, the tumors are not fully resectable, resulting in recurrence, malignant progression, and eventual death. Approximately 69-80% of grade II and III gliomas harbor mutations in the isocitrate dehydrogenase 1 gene (IDH1), of which 83-90% are found to be the IDH1-R132H mutation. Detection of the IDH1-R132H mutation should help in the differential diagnosis of grade II and III gliomas from other types of CNS tumors and help determine the boundary between the tumor and normal brain tissue. In this study, we established a highly sensitive antibody-based device, referred to as the immuno-wall, to detect the IDH1-R132H mutation in gliomas. The immuno-wall causes an immunoreaction in microchannels fabricated using a photo-polymerizing polymer. This microdevice enables the analysis of the IDH1 status with a small sample within 15 min with substantially high sensitivity. Our results suggested that 10% content of the IDH1-R132H mutation in a sample of 0.33 mu l volume, with 500 ng protein, or from 500 cells is theoretically sufficient for the analysis. The immuno-wall device will enable the rapid and highly sensitive detection of the IDH1-R132H mutation in routine clinical practice.

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  235. Crystal phase-controlled synthesis of rod-shaped AglnTe(2) nanocrystals for in vivo imaging in the near-infrared wavelength region Reviewed International journal

    Tatsuya Kameyama, Yujiro Ishigami, Hiroshi Yukawa, Taisuke Shimada, Yoshinobu Baba, Tetsuya Ishikawa, Susumu Kuwabata, Tsukasa Torimoto

    NANOSCALE   Vol. 8 ( 10 ) page: 5435 - 5440   2016

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    Rod-shaped AgInTe2 nanocrystals (NCs) exhibiting intense nearband edge photoluminescence in the near-infrared (NIR) wavelength region, were successfully prepared by the thermal reaction of metal acetates and Te precursors in 1-dodecanethiol. Increasing the reaction temperature resulted in the formation of larger AgInTe2 NCs with crystal structures varying from hexagonal to tetragonal at reaction temperatures of 280 degrees C or higher. The energy gap was increased from 1.13 to 1.20 eV with a decrease in rod width from 8.3 to 5.6 nm, accompanied by a blue shift in the photoluminescence (PL) peak wavelength from 1097 to 1033 nm. The optimal PL quantum yield was approximately 18% for AgInTe2 NCs with rod widths of 5.6 nm. The applicability of AgInTe2 NCs as a NIR-emitting material for in vivo biological imaging was examined by injecting AgInTe2 NC-incorporated liposomes into the back of a C57BL/6 mouse, followed by in vivo photoluminescence imaging in the NIR region.

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  236. Design of wave-shaped-micro-channel for active transportation of C. elegans

    Baba Y., Nakajima M., Ichikawa A., Fukuda T.

    2016 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS)     page: .   2016

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  237. Determination of six anti-Parkinson drugs using cyclodextrin-capillary electrophoresis method: application to pharmaceutical dosage forms Reviewed

    Abdallah M. Zeid, Jenny Jeehan M. Nasr, Fathalla F. Belal, Shinya Kitagawa, Noritada Kaji, Yoshinobu Baba, Mohamed I. Walash

    RSC ADVANCES   Vol. 6 ( 21 ) page: 17519 - 17530   2016

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    A novel capillary electrophoretic method was developed for the assay of two quaternary anti-Parkinson mixtures, entacapone, levodopa, carbidopa, and benserazide (mixture I), and selegiline, levodopa, carbidopa, and benserazide (mixture II), by using alpha-methyldopa as an internal standard. Furthermore, the method was extended for the determination of another anti-Parkinson drug, lisuride, as well as a psychoactive antihypertensive drug, alpha-methyldopa, without any modification of the general method. Separation and analyses of all compounds were simply achieved in an untreated fused-silica capillary tube (42.0 cm effective length and 50 mu m internal diameter) within 7 minutes under an applied voltage of 20 kV. Optimum separation and analyses were obtained using 25 mM borate buffer (pH 9.5) containing 5 mM beta-cyclodextrin as the background electrolyte. The apparatus was equipped with a diode array detector (DAD) to identify lisuride at 240 nm and all other drugs at 200 nm. The addition of 5 mM b-cyclodextrin to the borate buffer has a significant effect on the separation of entacapone and benserazide in mixture I, and on the separation of selegiline and benserazide in mixture II, which cannot be achieved without it. The proposed method was successfully applied to analyse the studied drugs in their multi-component and single-component pharmaceutical dosage forms. The analytical results proved the linearity (r(2) >= 0.9997), accuracy, precision (% RSD < 2), and selectivity of the proposed capillary electrophoretic method.

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  238. Functional double-shelled silicon nanocrystals for two-photon fluorescence cell imaging: spectral evolution and tuning

    Chandra Sourov, Ghosh Batu, Beaune Gregory, Nagarajan Usharani, Yasui Takao, Nakamura Jin, Tsuruoka Tohru, Baba Yoshinobu, Shirahata Naoto, Winnik Francoise M.

    NANOSCALE   Vol. 8 ( 16 ) page: 9009-9019   2016

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  239. Identifying DNA methylation in a nanochannel Reviewed

    Xiaoyin Sun, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Sakon Rahong, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

    SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS   Vol. 17 ( 1 ) page: 644 - 649   2016

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    DNA methylation is a stable epigenetic modification, which is well known to be involved in gene expression regulation. In general, however, analyzing DNA methylation requires rather time consuming processes (24-96 h) via DNA replication and protein modification. Here we demonstrate a methodology to analyze DNA methylation at a single DNA molecule level without any protein modifications by measuring the contracted length and relaxation time of DNA within a nanochannel. Our methodology is based on the fact that methylation makes DNA molecules stiffer, resulting in a longer contracted length and a longer relaxation time (a slower contraction rate). The present methodology offers a promising way to identify DNA methylation without any protein modification at a single DNA molecule level within 2 h.
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    DOI: 10.1080/14686996.2016.1223516

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  240. The role of <i>in vivo</i> fluorescence imaging of transplanted stem cells in regenerative medicine drug discovery research

    Yukawa Hiroshi, Baba Yoshinobu

    Drug Delivery System   Vol. 31 ( 2 ) page: 135 - 145   2016

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    © 2016, Japan Society of Drug Delivery System. All rights reserved. In vivo imaging diagnostic modalities play important roles in modern medicine. In this paper, we introduced in vivo fluorescence imaging technology of transplanted stem cells using quantum dots. Then, we showed the roles of in vivo fluorescence imaging technology of transplanted stem cells using quantum dots for clinical studies and drug developments of regenerative medicine in various tissues, organs and cancer immunity regions. The drug development in generative medicine is strongly expected by the interdisciplinary approach between in vivo fluorescence imaging technologies based on frontier nanotechnologies and regenerative medicine technologies in the future.

    DOI: 10.2745/dds.31.135

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  241. Design of wave-shaped-micro-channel for active transportation of C. elegans

    Baba Y, Nakajima M, Ichikawa A, Fukuda T

    2016 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS)     page: .   2016

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  242. Micro sand timer in glass membrane device separates single circulating tumor cells in blood

    D. Kuboyama, D. Onoshima, H. Yukawa, M. Tanaka, K. Ishikawa, M. Hori, Y. Baba

    20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016     page: 297 - 298   2016

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    We developed a size-exclusive micro sand timer in which a single cancer cell was trapped at the narrow neck through a trickle of blood from the upper bulb to the lower one. The cells in the bulbs could be directly subjected to enumeration and staining assays for identification of cancer cells in blood. A cell population with tumor markers was successfully detected as distinguished from other blood cells.

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  243. Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine Reviewed

    Daisuke Onoshima, Hiroshi Yukawa, Yoshinobu Baba

    Advanced Drug Delivery Reviews   Vol. 95   page: 2-14   2015.12

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  244. Multifunctional nanobiodevices in medical sciences Reviewed International journal

    Daisuke Onoshima, Hiroshi Yukawa, Yoshinobu Baba

    ADVANCED DRUG DELIVERY REVIEWS   Vol. 95 ( 1 ) page: 1 - 1   2015.12

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    DOI: 10.1016/j.addr.2015.11.006

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  245. Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine Reviewed International journal

    Daisuke Onoshima, Hiroshi Yukawa, Yoshinobu Baba

    ADVANCED DRUG DELIVERY REVIEWS   Vol. 95   page: 2 - 14   2015.12

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    A field of recent diagnostics and therapeutics has been advanced with quantum dots (QDs). QDs have developed into new formats of biomolecular sensing to push the limits of detection in biology and medicine. QDs can be also utilized as bio-probes or labels for biological imaging of living cells and tissues. More recently, QDs has been demonstrated to construct a multifunctional nanoplatform, where the QDs serve not only as an imaging agent, but also a nanoscaffold for diagnostic and therapeutic modalities. This review highlights the promising applications of multi-functionalized QDs as advanced nanosensors for diagnosing cancer and as innovative fluorescence probes for in vitro or in vivo stem cell imaging in regenerative medicine. (C) 2015 Elsevier B.V. All rights resrved.

    DOI: 10.1016/j.addr.2015.08.004

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  246. Micropillars fabricated on poly(methyl methacrylate) substrates for separation of microscale objects Reviewed

    Takao YASUI, Satoru ITO, Noritada KAJI, Manabu TOKESHI, and Yoshinobu BABA

    Analytical Sciences   Vol. 31 ( 11 ) page: 1197-1200   2015.11

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    DOI: 10.2116/analsci31.1197

  247. マイクロ化学チップを用いた単一DNA分子シークエンシング法

    加地範匡、馬場嘉信

    クリーンテクノロジー   Vol. 11   page: 5-8   2015.11

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  248. マイクロ化学チップを用いた単一DNA分子シークエンシング法

    加地範匡, 馬場嘉信

    クリーンテクノロジー   Vol. 11   page: 5-8   2015.11

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  249. IMMUNOSUPPRESSIVE EFFECT OF AUTOLOGOUS ADIPOSE-TISSUE DERIVED MESENCHYMAL STEM CELL IN A RAT LUNG TRANSPLANTATION MODEL

    Watanabe Hironosuke, Tsuchiya Tomoshi, Miyazaki Takuro, Matsumoto Keitaro, Yamasaki Naoya, Yukawa Hiroshi, Baba Yoshinobu, Nagayasu Takeshi

    TRANSPLANT INTERNATIONAL   Vol. 28   page: 164-164   2015.11

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  250. Micropillars Fabricated on Poly(methyl methacrylate) Substrates for Separation of Microscale Objects

    Yasui Takao, Ito Satoru, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    ANALYTICAL SCIENCES   Vol. 31 ( 11 ) page: 1197-1200   2015.11

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  251. Micropillars Fabricated on Poly(methyl methacrylate) Substrates for Separation of Microscale Objects Reviewed

    Takao Yasui, Satoru Ito, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

    ANALYTICAL SCIENCES   Vol. 31 ( 11 ) page: 1197 - 1200   2015.11

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    Development of polymeric microfluidic devices has played an important role in the recent, rapid progress of biomedical research. Here we report a fabrication method for micropillars on poly(methyl methacrylate) (PMMA) substrates for separation of microscale objects. The fabricated micropillars enable continuous separation of microparticles only by introducing fluids. The present method offers a new strategy to fabricate polymeric prototype devices for R&D work.

    DOI: 10.2116/analsci.31.1197

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  252. IMMUNOSUPPRESSIVE EFFECT OF AUTOLOGOUS ADIPOSE-TISSUE DERIVED MESENCHYMAL STEM CELL IN A RAT LUNG TRANSPLANTATION MODEL Reviewed

    Hironosuke Watanabe, Tomoshi Tsuchiya, Takuro Miyazaki, Keitaro Matsumoto, Naoya Yamasaki, Hiroshi Yukawa, Yoshinobu Baba, Takeshi Nagayasu

    TRANSPLANT INTERNATIONAL   Vol. 28   page: 164 - 164   2015.11

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  253. NIR-II近赤外領域における移植幹細胞in vivo蛍光イメージング

    湯川 博, 小野島 大介, 新岡 宏彦, 竹内 司, 大谷 敬亨, 三宅 淳, 石川 哲也, 馬場 嘉信

    日本バイオマテリアル学会大会予稿集   Vol. 37回   page: 113 - 113   2015.11

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  254. Superhydrophilic glass membrane device with open-microhole array for filtering and counting rare tumor cells Reviewed

    Akihiro Yonese, Daisuke Onoshima, Hiroshi Yukawa, Kenji Ishikawa, Masaru Hori, and Yoshinobu Baba

    Micro Total Analysis Systems 2015     page: 493-495   2015.10

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  255. PDMS-anchored nanowires for high throughput micro-rna extraction from extracellular vesicles in body fluid Reviewed

    D. Takeshita, T. Yasui, H. Yong, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 1516-1518   2015.10

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  256. A single cell nucleus array to monitor messenger-rna molecule transportation through nuclear membrane Reviewed

    N. Kaji, R. Koyama, T. Yasui, T. Higashiyama, Y. Baba

    Micro Total Analysis Systems 2015     page: 832-834   2015.10

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  257. A microchamber array device for studying genomic diversity in cancer cells at a single cell level Reviewed

    S. Ito, N. Kaji, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2015     page: 534-536   2015.10

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  258. A microchamber array device for studying genomic diversity in cancer cells at a single cell level Reviewed

    S. Ito, N. Kaji, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2015     page: 534-536   2015.10

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  259. A single cell nucleus array to monitor messenger-rna molecule transportation through nuclear membrane Reviewed

    N. Kaji, R. Koyama, T. Yasui, T. Higashiyama, Y. Baba

    Micro Total Analysis Systems 2015     page: 832-834   2015.10

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  260. PDMS-anchored nanowires for high throughput micro-rna extraction from extracellular vesicles in body fluid Reviewed

    D. Takeshita, T. Yasui, H. Yong, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 1516-1518   2015.10

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  261. Microfluidic approach for production of lipid nanoparticles-based nano medicine Reviewed

    M. Maeki, T. SAITO, Y. NODE, Y. Sato, T. Yasui, N. Kaji, A. Ishida, H. Tani, Y. Baba, H. Harashima, and M. Tokeshi

    Micro Total Analysis Systems 2015     page: 838-840   2015.10

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  262. Label-free detection of extracellular vesicles for cancer diagnosis Reviewed

    Taiga Ajiri, Takao Yasui, Akihiko Ishida, Hirofumi Tani, Yoshinobu Baba, Manabu Tokeshi

    Micro Total Analysis Systems 2015     page: 1789-1791   2015.10

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  263. Label-free detection of extracellular vesicles for cancer diagnosis Reviewed

    Taiga Ajiri, Takao Yasui, Akihiko Ishida, Hirofumi Tani, Yoshinobu Baba, Manabu Tokeshi

    Micro Total Analysis Systems 2015     page: 1789-1791   2015.10

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  264. Microfluidic approach for production of lipid nanoparticles-based nano medicine Reviewed

    M. Maeki, T. SAITO, Y. NODE, Y. Sato, T. Yasui, N. Kaji, A. Ishida, H. Tani, Y. Baba, H. Harashima, M. Tokeshi

    Micro Total Analysis Systems 2015     page: 838-840   2015.10

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  265. Cell deformability measurements for single cancer cells by ionic current in microfluidic devices Reviewed

    M. Sano, N. Kaji, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2015     page: 455-457   2015.10

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  266. Nanowire devices for extracellular vesicles analysis towards elucidation of intercellular communication Reviewed

    K. Tabuchi, T. Yasui, H. Yong, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 1510-1512   2015.10

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  267. Conformation and dynamic behavior of single DNA molecules in nanofluidic channels for detection of dna methylation Reviewed

    X. Sun, T. Yasui, S. Rahong, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 1115-1117   2015.10

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  268. Immuno-wall lab-on-chip companion diagnostic devices for rapid and low-cost detection of mutant epidermal growth factor receptors (EGFR) from cytological samples in lung cancer patients Reviewed

    T. Kasama, T. Hase, N. Nishiwaki, N. Yogo, M. Sato, M. Kondo, N. Kaji, M. Tokeshi, Y. Hasegawa and Y. Baba

    Micro Total Analysis Systems 2015     page: 925-927   2015.10

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  269. High-throughput methylation mapping by detecting fluorescently stained methylation sites at a single molecule level Reviewed

    A. Hattori, T. Yasui, N. Kaji, Y. Baba

    Micro Total Analysis Systems 2015     page: 861-863   2015.10

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  270. Cell deformability measurements for single cancer cells by ionic current in microfluidic devices Reviewed

    M. Sano, N. Kaji, T. Yasui, Y. Baba

    Micro Total Analysis Systems 2015     page: 455-457   2015.10

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  271. Nanowire devices for extracellular vesicles analysis towards elucidation of intercellular communication Reviewed

    K. Tabuchi, T. Yasui, H. Yong, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 1510-1512   2015.10

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  272. Immuno-wall lab-on-chip companion diagnostic devices for rapid and low-cost detection of mutant epidermal growth factor receptors (EGFR) from cytological samples in lung cancer patients Reviewed

    T. Kasama, T. Hase, N. Nishiwaki, N. Yogo, M. Sato, M. Kondo, N. Kaji, M. Tokeshi, Y. Hasegawa, Y. Baba

    Micro Total Analysis Systems 2015     page: 925-927   2015.10

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  273. High-throughput methylation mapping by detecting fluorescently stained methylation sites at a single molecule level Reviewed

    A. Hattori, T. Yasui, N. Kaji, Y. Baba

    Micro Total Analysis Systems 2015     page: 861-863   2015.10

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  274. Conformation and dynamic behavior of single DNA molecules in nanofluidic channels for detection of dna methylation Reviewed

    X. Sun, T. Yasui, S. Rahong, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 1115-1117   2015.10

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  275. Nanowire lysis and dna extracrtion from a single bacterium for bacteria analysis Reviewed

    T. Yasui, K. Otsuka, M. Takeuchi1, T. Yanagida, N. Kaji, M. Kanai, S. Rahong, K. Nagashima, T. Naito, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 320-322   2015.10

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  276. Highly sensitive ionic current sensing system with optical observation for discriminating a wide diversity of sizes of bacteria with contaminants Reviewed

    H. Yasaki, T. Yasui, S. Rahong, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 314-316   2015.10

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  277. Highly sensitive ionic current sensing system with optical observation for discriminating a wide diversity of sizes of bacteria with contaminants Reviewed

    H. Yasaki, T. Yasui, S. Rahong, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 314-316   2015.10

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  278. Nanowire lysis and dna extracrtion from a single bacterium for bacteria analysis Reviewed

    T. Yasui, K. Otsuka, M. Takeuchi, T. Yanagida, N. Kaji, M. Kanai, S. Rahong, K. Nagashima, T. Naito, T. Kawai, Y. Baba

    Micro Total Analysis Systems 2015     page: 320-322   2015.10

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  279. Hydrodynamic nonadhesive cell retention in a microfluidic circuit for stressless suspension culture Reviewed

    Toyohito Naito, Noritada Kaji, Manabu Tokeshi, Takuya Kubo, Yoshinobu Baba, Koji Otsuka

    Analytical Methods   Vol. 7 ( 17 ) page: 7264 - 7269   2015.9

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    © The Royal Society of Chemistry. Cell collection based on deterministic lateral displacement (DLD) and cell circulation with a loop channel are two component technologies for stressless cell retention which have been developed with a view to working toward suspension culture in a microfluidic channel. DLD devices with low array angles collect floating S. cerevisiae through an array effectively. The DLD device with an array angle of 2.6°showed an efficiency of 91.7%. Two types of loop channels with a piezoelectrie pump make a stable two-phase laminar flow of a pre-filled fluid and supplied fluid. A loop channel with a connection between an inlet and outlet on the opposite side replaces a filled fluid in the channel with a supplied fluid, which is essential for supplying nutrient rich medium to cells in microfluidic channels as well as retaining cells in a microenvironment without external stresses.

    DOI: 10.1039/c5ay00485c

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  280. Development of Microfluidic Devices for Rapid, Low-Cost Detection of EGFR Mutations in Cytological Samples from Patients with Lung Cancer

    Hase Tetsunari, Kasama Toshihiro, Nishiwaki Nanako, Yogo Naoyuki, Sato Mitsuo, Kaji Noritada, Kondo Masashi, Tokeshi Manabu, Baba Yoshinobu, Hasegawa Yoshinori

    JOURNAL OF THORACIC ONCOLOGY   Vol. 10 ( 9 ) page: S585-S585   2015.9

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  281. Fluorescence Quenching of CdSe/ZnS Quantum Dots by Using Black Hole Quencher Molecules Intermediated With Peptide for Biosensing Application Reviewed

    Sreenadh Sasidharan Pillai, Hiroshi Yukawa, Daisuke Onoshima,Vasudevanpillai Biju, and Yoshinobu Baba

    Cell Medicine   Vol. 8   page: 57-62   2015.8

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    DOI: 10.3727/215517915X689074

  282. Hepatic arterial infusion chemotherapy with fine-powder cisplatin and iodized-oil suspension in patients with intermediate-stage and advanced-stage (Barcelona Clinic Liver Cancer stage-B or stage-C) hepatocellular carcinoma: multicenter phase-II clinical study

    Takaki H.

    International Journal of Clinical Oncology   Vol. 20 ( 4 ) page: 745-754   2015.8

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    DOI: 10.1007/s10147-014-0773-4

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  283. ナノバイオデバイスが拓く次世代医療・創薬 Reviewed

    馬場嘉信

    ファルマシア   Vol. 51   page: 747-749   2015.8

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  284. ナノバイオデバイスによる単一細胞解析と単一生体分子解析 Reviewed

    安井隆雄,馬場嘉信

    分析化学 特集号「ミクロで拓く分析化学」   Vol. 64 ( 6 ) page: 413-419   2015.7

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  285. The Scope of Analytical Chemistry Reviewed

    Jonathan V. Sweedler, Daniel W. Armstrong, Yoshinobu Baba, Gert Desmet, Norman Dovichi, Andrew Ewing, Catherine C. Fenselau, Robert T. Kennedy, Cynthia K. Larive, Frances S. Ligler, Richard L. McCreery, Reinhard Niessner, Jeanne E. Pemberton, Weihong Tan, David R. Walt, John R. YatesIII, Renato Zenobi, and Xinrong Zhang

    Analytical Chemistry   Vol. 87 ( 13 ) page: 6425-6425   2015.7

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  286. Nanobiodevice-based Single Cell Analysis and Single Biomolecule Analysis

    YASUI Takao, BABA Yoshinobu

    BUNSEKI KAGAKU   Vol. 64 ( 6 ) page: 413-419   2015.7

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    A nanobiodevice is a piece of contrivance, equipment, machine, or component, which is created by overlapping multidisciplinary activities associated with nanotechnology and biotechnology, intended for biological, medical, and clinical purposes. We developed nanobiodevices for biomedical applications, including single cancer-cell diagnosis for cancer metastasis, circulating tumor cell (CTC) detection by microfluidic devices, nanopillar devices for the ultrafast analysis of genomic DNA and microRNA, nanopore devices for single DNA and microRNA sequencing, nanowire devices for exosome analysis, single-molecular epigenetic analysis, quantum switching <i>in vivo</i> imaging of iPS cells and stem cells, and quantum technology-based cancer theranostics.

    DOI: 10.2116/bunsekikagaku.64.413

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  287. ナノバイオデバイスによる単一細胞解析と単一生体分子解析 Reviewed

    安井隆雄, 馬場嘉信

    分析化学 特集号「ミクロで拓く分析化学」   Vol. 64 ( 6 ) page: 413-419   2015.7

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  288. The Scope of Analytical Chemistry Reviewed

    Jonathan V. Sweedler, Daniel W. Armstrong, Yoshinobu Baba, Gert Desmet, Norman Dovichi, Andrew Ewing, Catherine C. Fenselau, Robert T. Kennedy, Cynthia K. Larive, Frances S. Ligler, Richard L. McCreery, Reinhard Niessner, Jeanne E. Pemberton, Weihong Tan, David R. Walt, John R. Yates, Renato Zenobi, Xinrong Zhang

    ANALYTICAL CHEMISTRY   Vol. 87 ( 13 ) page: 6425 - 6425   2015.7

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    DOI: 10.1021/acs.analchem.5b02231

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  289. Three-dimensional Nanowire Structures for Ultra-Fast Separation of DNA, Protein and RNA Molecules

    Rahong Sakon, Yasui Takao, Yanagida Takeshi, Nagashima Kazuki, Kanai Masaki, Meng Gang, He Yong, Zhuge Fuwei, Kaji Noritada, Kawai Tomoji, Baba Yoshinobu

    SCIENTIFIC REPORTS   Vol. 5   page: 10584   2015.6

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    DOI: 10.1038/srep10584

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  290. イムノピラーデバイスの高性能化:抗体固定化担体の改良 Reviewed

    西脇 奈菜子,笠間 敏博,石田 晃彦,谷 博文,馬場 嘉信,渡慶次 学

    分析化学 特集号「生(bio)」   Vol. 64 ( 5 ) page: 329-335   2015.6

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  291. Nanobiodevice-based Single Cell Analysis and Single Biomolecule Analysis

    Yasui Takao, Baba Yoshinobu

    BUNSEKI KAGAKU   Vol. 64 ( 6 ) page: 413-419   2015.6

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  292. Three-dimensional Nanowire Structures for Ultra-Fast Separation of DNA, Protein and RNA Molecules, Reviewed

    Sakon Rahong, Takao Yasui, Takeshi Yanagida, Kazuki Nagashima, Masaki Kanai, Gang Meng, Yong He, Fuwei Zhuge, Noritada Kaji, Tomoji Kawai and Yoshinobu Baba,

    Sci. Rep.   Vol. 5   page: 10584   2015.5

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  293. Rapid, highly sensitive, and simultaneous detection of staphylococcal enterotoxins in milk by using immuno-pillar devices Reviewed

    Toshihiro Kasama, Mai Ikami, Wanchun Jin, Keiko Yamada, Noritada Kaji, Yusuke Atsumi, Makoto Mizutani, Atsushi Murai, Akira Okamoto, Takao Namikawa, Michio Ohta, Manabu Tokeshi, and Yoshinobu Baba

    Analytical Methods   Vol. 12 ( 7 ) page: 5092-5095   2015.5

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  294. Three-dimensional Nanowire Structures for Ultra-Fast Separation of DNA, Protein and RNA Molecules, Reviewed

    Sakon Rahong, Takao Yasui, Takeshi Yanagida, Kazuki Nagashima, Masaki Kanai, Gang Meng, Yong He, Fuwei Zhuge, Noritada Kaji, Tomoji Kawai, Yoshinobu Baba

    Sci. Rep.   Vol. 5   page: 10584   2015.5

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  295. A Strategy for Synthesis of Lipid Nanoparticles Using Microfluidic Devices with a Mixer Structure RSC Advances Reviewed

    M. Maeki, T. Saito, Y. Sato, T. Yasui, N. Kaji, A. Ishida, H. Tani, Y. Baba, H. Harashima, M. Tokeshi

    RSC Advances   Vol. 5   page: 46181-46185   2015.5

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  296. A Strategy for Synthesis of Lipid Nanoparticles Using Microfluidic Devices with a Mixer Structure RSC Advances Reviewed

    M. Maeki, T. Saito, Y. Sato, T. Yasui, N. Kaji, A. Ishida, H. Tani, Y. Baba, H. Harashima, M. Tokeshi

    RSC Advances   Vol. 5   page: 46181-46185   2015.5

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  297. Arrangement of a Nanostructure Array To Control Equilibrium and Nonequilibrium Transports of Macromolecules

    Yasui Takao, Kaji Noritada, Ogawa Ryo, Hashioka Shingi, Tokeshi Manabu, Horiike Yasuhiro, Baba Yoshinobu

    NANO LETTERS   Vol. 15 ( 5 ) page: 3445 - 51   2015.5

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    DOI: 10.1021/acs.nanolett.5b00783

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  298. Three-dimensional fabrication for microfluidics by conventional techniques and equipment used in mass production Reviewed

    Toyohiro Naito *, Makoto Nakamura, Noritada Kaji, Takuya Kubo, Yoshinobu Baba, Koji Otsuka

    Micromachies   Vol. 7   page: 82   2015.5

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    DOI: 10.3390/mi7050082

  299. Development of High-performance Immuno-pillar Devices: Improvement of Antibody-immobilized Solid Support

    Nishiwaki Nanako, Kasama Toshihiro, Ishida Akihiko, Tani Hirofumi, Baba Yoshinobu, Tokeshi Manabu

    BUNSEKI KAGAKU   Vol. 64 ( 5 ) page: 329-335   2015.5

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  300. Arrangement of a nanostructure array to control equilibrium and non-equilibrium transports of macromolecules Reviewed

    Yasui Takao, Kaji Noritada, Ogawa Ryo, Hashioka Shingi, Tokeshi Manabu,Horiike Yasuhiro, Baba Yoshinobu

    Nano Lett.   Vol. 15   page: 3445-3451   2015.4

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  301. Arrangement of a nanostructure array to control equilibrium and non-equilibrium transports of macromolecules Reviewed

    Yasui Takao, Kaji Noritada, Ogawa Ryo, Hashioka Shingi, Tokeshi Manabu, Horiike Yasuhiro, Baba Yoshinobu

    Nano Lett.   Vol. 15   page: 3445-3451   2015.4

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  302. Self-assembled Nanowire Arrays as Three-dimensional Nanopores for Filtration of DNA Molecules Reviewed

    Sakon RAHONG, Takao YASUI, Takeshi YANAGIDA, Kazuki NAGASHIMA, Masaki KANAI, Gang MENG, Yong HE, Fuwei ZHUGE, Noritada KAJI, Tomoji KAWAI, and Yoshinobu BABA

    Anal. Sci.   Vol. 31 ( 3 ) page: 153-157   2015.3

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  303. 量子ドットによる移植幹細胞in vivoイメージング Reviewed

    湯川博、馬場嘉信

    分析化学 特集号「生(bio)」   Vol. 64 ( 2 ) page: 89-97   2015.3

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  304. ナノバイオデバイス創製と未来医療への展開 ナノとバイオと医療の境界領域に挑む Reviewed

    馬場嘉信

    化学と工業   Vol. 68 ( 3 ) page: 274-276   2015.3

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  305. Self-assembled Nanowire Arrays as Three-dimensional Nanopores for Filtration of DNA Molecules

    Rahong Sakon, Yasui Takao, Yanagida Takeshi, Nagashima Kazuki, Kanai Masaki, Meng Gang, He Yong, Zhuge Fuwei, Kaji Noritada, Kawai Tomoji, Baba Yoshinobu

    ANALYTICAL SCIENCES   Vol. 31 ( 3 ) page: 153-157   2015.3

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  306. Self-assembled Nanowire Arrays as Three-dimensional Nanopores for Filtration of DNA Molecules Reviewed

    Sakon Rahong, Takao Yasui, Takeshi Yanagida, Kazuki Nagashima, Masaki Kanai, Gang Meng, Yong He, Fuwei Zhuge, Noritada Kaji, Tomoji Kawai, Yoshinobu Baba

    ANALYTICAL SCIENCES   Vol. 31 ( 3 ) page: 153 - 157   2015.3

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    Molecular filtration and purification play important roles for biomolecule analysis. However, it is still necessary to improve efficiency and reduce the filtration time. Here, we show self-assembled nanowire arrays as three-dimensional (3D) nanopores embedded in a microfluidic channel for ultrafast DNA filtration. The 3D nanopore structure was formed by a vapor-liquid-solid (VLS) nanowire growth technique, which allowed us to control pore size of the filtration material by varying the number of growth cycles. lambda DNA molecules (48.5 kbp) were filtrated from a mixture of T4 DNA (166 kbp) at the entrance of the 3D nanopore structure within 1 s under an applied electric field. Moreover, we observed single DNA molecule migration of T4 and lambda DNA molecules to clarify the filtration mechanism. The 3D nanopore structure has simplicity of fabrication, flexibility of pore size control and reusability for biomolecule filtration. Consequently it is an excellent material for biomolecular filtration.

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  307. 私の自慢 ナノバイオデバイス創製と未来医療への展開 : ナノとバイオと医療の境界領域に挑む

    馬場 嘉信

    化学と工業 = Chemistry & chemical industry   Vol. 68 ( 3 ) page: 274 - 276   2015.3

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  308. Influence of Autofluorescence Derived From Living Body on In Vivo Fluorescence Imaging Using Quantum Dots International journal

    Yukawa Hiroshi, Watanabe Masaki, Kaji Noritada, Baba Yoshinobu

    CELL MEDICINE   Vol. 7 ( 2 ) page: 75 - 82   2015.2

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    DOI: 10.3727/215517914X685169

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  309. In vivo Imaging of Transplanted Stem Cells Using Quantum Dots

    Yukawa Hiroshi, Baba Yoshinobu

    BUNSEKI KAGAKU   Vol. 64 ( 2 ) page: 89-97   2015.2

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  310. In vivo Imaging of Transplanted Stem Cells Using Quantum Dots Reviewed

    Hiroshi Yukawa, Yoshinobu Baba

    BUNSEKI KAGAKU   Vol. 64 ( 2 ) page: 89 - 97   2015.2

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    Quantum dots (QDs) have excellent fluorescence properties compared to traditional fluorescence probes. Thus, the optical application of QDs is in a rapid expansion to each field of analytical chemistry. In this paper, we described about the application of QDs to regenerative medicine, especially stem cell transplantation therapy. Specifically, labeling technologies of stem cells by QDs composed of semiconductor materials in combination with poly-cationic liposome (Lipofectamine) or cell-penetrating peptide (octa-arginine) were reviewed. Moreover, in vivo imaging technology of transplanted stem cells in mice by QDs emitting fluorescence in near-infrared region, which could be detected by fluorescence in vivo imaging machines, such as an IVIS imaging system, was reviewed.

    DOI: 10.2116/bunsekikagaku.64.89

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  311. マイクロ抽出場によるヒト細胞由来のマイクロRNA抽出法 Reviewed

    岡本 行広,日比野 理人,加地 範匡, 渡慶次 学, 馬場 嘉信

    分析化学   Vol. 64   page: 9-13   2015.1

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  312. ここまで進んだがんの診断 エクソソーム・マイクロRNAによる超早期がん診断の最前線 Reviewed

    湯川博,馬場嘉信

    ライフライン21 がんの先進医療   Vol. 16   page: 46-48   2015.1

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  313. Microfluidic transfer of liquid interface for parallel stretching and stamping of terminal-unmodified single DNA molecules between zigzag-shaped microgrooves Reviewed

    Hirotoshi Yasaki, Daisuke Onoshima, Takao Yasui, Hiroshi Yukawa, Notitada Kaji, and Yoshinobu Baba

    Lab on a Chip   Vol. 15   page: 135-140   2015.1

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  314. Microfluidic transfer of liquid interface for parallel stretching and stamping of terminal-unmodified single DNA molecules between zigzag-shaped microgrooves Reviewed

    Hirotoshi Yasaki, Daisuke Onoshima, Takao Yasui, Hiroshi Yukawa, Notitada Kaji, Yoshinobu Baba

    Lab on a Chip   Vol. 15   page: 135-140   2015.1

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  315. Carbon nanotubes and modern nanoagriculture Reviewed

    Maged F. Serag, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

    Nanotechnology and Plant Sciences: Nanoparticles and Their Impact on Plants     page: 183 - 201   2015.1

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    © Springer International Publishing Switzerland 2015. Since their discovery, carbon nanotubes have been prominent members of the nanomaterial family. Owing to their extraordinary physical, chemical, and mechanical properties, carbon nanotubes have been proven to be a useful tool in the field of plant science. They were frequently perceived to bring about valuable biotechnological and agricultural applications that still remain beyond experimental realization. An increasing number of studies have demonstrated the ability of carbon nanotubes to traverse different plant cell barriers. These studies, also, assessed the toxicity and environmental impacts of these nanomaterials. The knowledge provided by these studies is of practical and fundamental importance for diverse applications including intracellular labeling and imaging, genetic transformation, and for enhancing our knowledge of plant cell biology. Although different types of nanoparticles have been found to activate physiological processes in plants, carbon nanotubes received particular interest. Following addition to germination medium, carbon nanotubes enhanced root growth and elongation of some plants such as onion, cucumber and rye-grass. They, also, modulated the expression of some genes that are essential for cell division and plant development. In addition, multi-walled carbon nanotubes were evidenced to penetrate thick seed coats, stimulate germination, and to enhance growth of young tomato seedlings. Multi-walled carbon nanotubes can penetrate deeply into the root system and further distribute into the leaves and the fruits. In recent studies, carbon nanotubes were reported to be chemically entrapped into the structure of plant tracheary elements. This should activate studies in the fields of plant defense and wood engineering. Although, all of these effects on plant physiology and plant developmental biology have not been fully understood, the valuable findings promises more research activity in the near future toward complete scientific understanding of the behavior of carbon nanotubes in plants. This chapter focuses on the impact of carbon nanotubes on plants and the potential use of these unique nanomaterials in crop management and plant biotechnology.

    DOI: 10.1007/978-3-319-14502-0_10

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  316. Development of a Micro RNA Extraction Chip from Human Tumor Cells

    Okamoto Yukihiro, Hibino Ayato, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    BUNSEKI KAGAKU   Vol. 64 ( 1 ) page: 9-13   2015.1

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  317. Nanobiodevices for single biomolecular separations

    Y. Baba

    Chromatography   Vol. 36   page: 73-79   2015

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  318. Influence of Autofluorescence Derived From Living Body on In Vivo Fluorescence Imaging Using Quantum Dots Reviewed

    Yukawa, Hiroshi; Watanabe, Masaki; Kaji, Noritada; Baba, Yoshinobu

    Cell Medicine   Vol. 7 ( 2 ) page: 75-82   2015

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  319. Multifunctional nanobiodevices in Medical Sciences Reviewed

    D. Onoshima, H. Yukawa, Y. Baba

    Adv. Drug Del. Rev.   Vol. 95 ( 1 ) page: 00   2015

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  320. A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure International journal

    Maeki Masatoshi, Saito Tatsuyoshi, Sato Yusuke, Yasui Takao, Kaji Noritada, Ishida Akihiko, Tani Hirofumi, Baba Yoshinobu, Harashima Hideyoshi, Tokeshi Manabu

    RSC ADVANCES   Vol. 5 ( 57 ) page: 46181 - 46185   2015

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    DOI: 10.1039/c5ra04690d

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  321. Development of a Micro RNA Extraction Chip from Human Tumor Cells

    OKAMOTO Yukihiro, HIBINO Ayato, KAJI Noritada, TOKESHI Manabu, BABA Yoshinobu

    BUNSEKI KAGAKU   Vol. 64 ( 1 ) page: 9 - 13   2015

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    The importance of micro RNA analysis has been significantly increasing because the role of micro RNA in the human body has been gradually revealed. Despite its importance, the analysis has suffered from several troublesome pretreatments, which hamper any easy analysis. Therefore, an easy and high-throughput pretreatment method has been demanded. In this paper, we focused on the great advantages of microchip pretreatments over conventional manual pretreatments and developed a microchip for micro RNA extraction. To simplify microchip fabrication, we adopted poly(dimethyl siloxane) (PDMS) microchip and a silica membrane, which has rolls in RNA extraction fields. With silica membranes and the adhesion nature of PDMS, we could easily fabricate RNA extraction fields in the microchip. With this microchip, we successfully extracted micro RNA from cancer tumor cells. Though this is a preliminary experiment, and still has many improvement points, our device is expected to be applied for easy and fast micro RNA extraction from biological samples.

    DOI: 10.2116/bunsekikagaku.64.9

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  322. Development of High-performance Immuno-pillar Devices: Improvement of Antibody-immobilized Solid Support

    NISHIWAKI Nanako, KASAMA Toshihiro, ISHIDA Akihiko, TANI Hirofumi, BABA Yoshinobu, TOKESHI Manabu

    BUNSEKI KAGAKU   Vol. 64 ( 5 ) page: 329 - 335   2015

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    In order to realize ultra-early diagnosis of disease in practical applications, we have fabricated next-generation immuno-pillar devices with higher sensitivity. In the newly developed devices, capture antibodies were immobilized on affinity beads based on chemical bonding, while in the previous-generation ones, polystyrene beads were used for physical adsorption-based immobilization. To evaluate the sensitivity of the next-generation immuno-pillar device, we quantitatively analyzed C-reactive protein (CRP). The limit of detection was estimated to be 0.1 ng mL</sup>&minus;1</sup> (total assay time, 23 min), which was twoorders of magnitude lower than that obtained by using the previous-generation immuno-pillar device, and was low enough to perform the CRP test. In addition, we investigated the storage stability of the immuno-pillar device, and confirmed that the device can retain its performance for over 9 months.

    DOI: 10.2116/bunsekikagaku.64.329

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  323. Microfluidic transfer of liquid interface for parallel stretching and stamping of terminal-unmodified single DNA molecules in zigzag-shaped microgrooves

    Yasaki Hirotoshi, Onoshima Daisuke, Yasui Takao, Yukawa Hiroshi, Kaji Noritada, Baba Yoshinobu

    LAB ON A CHIP   Vol. 15 ( 1 ) page: 135-140   2015

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    DOI: 10.1039/c4lc00990h

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  324. Nano- and Microbiodevices for High-Performance Separation of Biomolecules International journal

    Baba Yoshinobu

    CHROMATOGRAPHY   Vol. 36 ( 3 ) page: 73-79 - 79   2015

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    DOI: 10.15583/jpchrom.2015.030

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  325. Rapid, highly sensitive, and simultaneous detection of staphylococcal enterotoxins in milk by using immuno-pillar devices Reviewed

    Toshihiro Kasama, Mai Ikami, Wanchun Jin, Keiko Yamada, Noritada Kaji, Yusuke Atsumi, Makoto Mizutani, Atsushi Murai, Akira Okamoto, Takao Namikawa, Michio Ohta, Manabu Tokeshi, Yoshinobu Baba

    ANALYTICAL METHODS   Vol. 7 ( 12 ) page: 5092 - 5095   2015

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    Staphylococcal enterotoxins (SEs) have repeatedly caused food poisoning incidents worldwide. Some of the challenges associated with food poisoning outbreaks are that traditional detection methods are expensive and require long processing times and trained technicians. Microchannel devices represent a potential detection method by which these difficulties can be overcome. In this paper, we propose that immuno-pillar devices may represent a rapid, highly sensitive, and low-cost analytical system for the simultaneous detection of staphylococcal enterotoxin types A, B, and D (SEA, SEB, and SED) in milk. To prepare milk samples simulating food contaminated with SEs, commercial milk was spiked with equal amounts of SEA, SEB, and SED. A quantitative analysis of the milk samples was performed within 15 min by using the microchannel device. The analysis required only 0.5 mu L of untreated milk sample. The resultant limit of detection was 15.6 pg mL(-1) for each SE, and the total assay time and sensitivity were markedly shorter and higher, respectively, than those for commercially available assay kits. The detection range of each enterotoxin using these devices was estimated as 15.6 pg mL(-1) to 100 ng mL(-1), which completely covers the SE concentrations that can lead to foodborne diseases based on the U.S. Food and Drug Administration's criterion for the infectious SE dose in SE poisoning (1 mu g SE). Using our devices, frequent assessment of food potentially contaminated with SE is possible.

    DOI: 10.1039/c5ay00698h

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  326. Self-assembled nanowire arrays as three-dimensional nanopores for filtration of DNA molecules.

    Rahong S, Yasui T, Yanagida T, Nagashima K, Kanai M, Meng G, He Y, Zhuge F, Kaji N, Kawai T, Baba Y

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 31 ( 3 ) page: 153-7   2015

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    DOI: 10.2116/analsci.31.153

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  327. ナノバイオデバイスが拓く未来医療・創薬

    馬場 嘉信

    ファルマシア   Vol. 51 ( 8 ) page: 747 - 749   2015

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    ナノテクノロジーは,半導体微細加工技術や自己組織化技術により,原子・分子サイズで精密にサイズを制御したナノバイオデバイスを開発することができる.私の研究室は,ナノテクノロジーを駆使して,医工薬などの異分野融合の基礎研究を展開するとともに,産学連携による医療・創薬応用可能なナノバイオデバイスの実用化を進めており,ナノポア1分子DNAシークエンシング※,単一分子計測・単一細胞計測に基づくがん超早期診断と疾患診断,がん治療・ドラッグデリバリーシステム(drug delivery system:DDS),iPS細胞再生医療用<i>in vivo</i>イメージング,がん診断・治療融合などの成果を上げてきた.<br>本稿では,私が研究を始めた動機から,どのように異分野の壁を乗り越えて,基礎研究から実用化まで研究を展開してきたのか振り返ってみたい.

    DOI: 10.14894/faruawpsj.51.8_747

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  328. Analysis of exosomes derived from cancer cells by nanobiodevices

    Yukawa Hiroshi, Baba Yoshinobu

    Organ Biology   Vol. 22 ( 2 ) page: 193-198   2015

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    We herein showed the analysis of exosomes derived from cancer cells by nanobiodevices. At fi rst, the nano-pore device formed by an electrode couple on a nano-pore was developed. The number and size of exosomes could be analyzed by measuring the current value of the tunnel current of exosomes in the culture supernatant poured into nano-pore device. Next, the nano-wire device formed by nano-wires on a microfl uidic device made from polymethylmethacrylate (PMMA) was developed. The exosomes could be collected from the culture supernatant with high effi ciency by using this nano-wire device, and then miRNA existing in the exosomes could be extracted by pouring the miRNA extraction liquid into the nanowire device. In addition, these devices were available to the analysis of exosomes in the serum and urine. Therefore, the analysis of exosomes derived from cancer cells by nanobiodevices may be useful for the diagnosis of cancers in early stage.

    DOI: 10.11378/organbio.22.193

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  329. High-speed separation methods for nucleic acids by nanopillar and nanowire chips

    Kaji Noritada, Baba Yoshinobu

    Electrophoresis Letters   Vol. 59 ( 2 ) page: 61-63   2015

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    DOI: 10.2198/electroph.59.61

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  330. ナノポア1分子DNAシークエンシング技術

    馬場 嘉信

    ファルマシア   Vol. 51 ( 8 ) page: 775_1-775_1   2015

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    シリコン上に,DNAの直径と同程度(2nm)の孔(ナノポア)を形成し,ナノポア中にDNAが通り抜ける間隔で電極を作成したデバイスを用いて,DNAのシークエンシングを行う技術である.ナノポア中の電極間にトンネル電流を流し,1分子の1本鎖DNAを一定速度で通過させると,DNAの各塩基の電子状態の違いにより,トンネル電流値が変化するために,その変化量を解析しDNA配列を解読できる.DNA解読速度は,1秒間に1,000塩基程度であり,1,000個のナノポアを並列化することで,1時間で30億塩基のヒト・ゲノム解析が可能になる.DNAのみならず,RNA,メチル化DNA,タンパク質もシークエンシング可能である.

    DOI: 10.14894/faruawpsj.51.8_775_1

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  331. Influence of Autofluorescence Derived From Living Body on In Vivo Fluorescence Imaging Using Quantum Dots Reviewed

    Yukawa, Hiroshi, Watanabe, Masaki, Kaji, Noritada, Baba, Yoshinobu

    Cell Medicine   Vol. 7 ( 2 ) page: 75-82   2015

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  332. Nanobiodevices for single biomolecular separations

    Y. Baba

    Chromatography   Vol. 36   page: 73-79   2015

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  333. Superhydrophilic glass membrane device with open-microhole array for filtering and counting rare tumor cells

    A. Yonese, D. Onoshima, H. Yukawa, K. Ishikawa, M. Hori, Y. Baba

    MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences     page: 493 - 495   2015

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    © 15CBMS-0001. We report the development of a glass membrane filter device with open microholes for size-based isolation with direct on-chip characterization of rare tumor cells at a single cell level. The enhanced wettability by exposure to an atmospheric plasma enabled cell suspension to flow through the holes and single tumor cells were successfully trapped inside the holes. Different plasma-exposure amounts and directions were studied to evaluate the trapping efficiency of the device for optimizing the condition of device. This device can be applied to medical diagnosis of cancer metastasis in the future.

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  334. ナノバイオデバイスが拓く未来医療

    馬場嘉信

      Vol. 7 ( 6 ) page: 1-15   2014.12

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  335. Carbon nanowall scaffold to control culturing of cervical cancer cells Reviewed

    Hitoshi Watanabe, Hiroki Kondo, Yukihiro Okamoto, Mineo Hiramatsu, Makoto Sekine, Yoshinobu Baba, Masaru Hori

    Applied Physics Letters   Vol. 105 ( 24 )   2014.12

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    © 2014 AIP Publishing LLC. The effect of carbon nanowalls (CNWs) on the culturing rate and morphological control of cervical cancer cells (HeLa cells) was investigated. CNWs with different densities were grown using plasma-enhanced chemical vapor deposition and subjected to post-growth plasma treatment for modification of the surface terminations. Although the surface wettability of the CNWs was not significantly dependent on the CNWdensities, the cell culturing rates were significantly dependent. Morphological changes of the cells were not significantly dependent on the density of CNWs. These results indicate that plasma-induced surface morphology and chemical terminations enable nanobio applications using carbon nanomaterials.

    DOI: 10.1063/1.4902054

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  336. Synthesis and Reactions of Ynolates via a Stop-Flow Method with a Flow Microreactor Reviewed

    Toshiya Yoshiiwa, Satoshi Umezu, Manabu Tokeshi, Yoshinobu Babad and Mitsuru Shindo

    J. Flow Chem.   Vol. 4   page: 180-184   2014.12

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  337. Synthesis and Reactions of Ynolates via a Stop-Flow Method with a Flow Microreactor Reviewed

    Toshiya Yoshiiwa, Satoshi Umezu, Manabu Tokeshi, Yoshinobu Babad, Mitsuru Shindo

    J. Flow Chem.   Vol. 4   page: 180-184   2014.12

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  338. 超解像蛍光顕微鏡の開発

    加地範匡、渡慶次学、馬場嘉信

    現代化学   ( 12 ) page: 31-34   2014.12

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  339. 光学顕微鏡の限界を超える ノーベル化学賞に輝く超解像顕微鏡の世界

    馬場嘉信

    化学と工業   Vol. 67 ( 12 ) page: 1065-1066   2014.12

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  340. 2014年ノーベル化学賞 超解像蛍光顕微鏡の開発

    加地 範匡, 渡慶次 学, 馬場 嘉信

    現代化学   ( 525 ) page: 31 - 34   2014.12

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  341. 光学顕微鏡の限界を超える ノーベル化学賞に輝く超解像顕微鏡の世界

    馬場嘉信

    化学と工業   Vol. 67 ( 12 ) page: 1065-1066   2014.12

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  342. Nanopillar, Nanowall, and Nanowire Devices for Fast Separation of Biomolecules

    Takao Yasui, Sakon Rahong, Noritada Kaji, Yoshinobu Baba

    ISRAEL JOURNAL OF CHEMISTRY   Vol. 54 ( 11-12 ) page: 1556 - 1563   2014.11

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    Nanostructures based on nanotechnologies have opened up a novel research field for the fast analysis of biomolecules with ultrahigh resolution, including the analysis of single biomolecules. Nanostructures for electrophoretic separation, especially, are an exciting topic among researchers in many areas, and their designs are widely expected to contribute to the goal of developing a single separation tool for a wide range of biomolecules. In this review, nanopillar, nanowall, and nanowire devices are introduced for fast separation of DNA molecules and protein samples, and the numerous advantages of these devices are described. This review also outlines the fabrication processes for nanostructures, including top-down and bottom-up nanofabrication approaches. Besides describing the fast separation of biomolecules, the electroosmotic flow (EOF) suppression effect, and its related online concentration technique in nanopillar devices, is reviewed. The nanowall devices have the unique feature that longer DNA molecules migrate faster than shorter ones, and that is completely different from the separation behavior of DNA molecules based on nanopillar devices. The feasibility is shown for self-assembly of the nanowire structure embedded in a microchannel on a fused silica substrate, as a means to separate DNA molecules. Applications of a newly-fabricated 3D network structure with spatial density control for the fast separation of a wide range of DNA molecules are also given.

    DOI: 10.1002/ijch.201400102

    Web of Science

  343. ここまで進んだがんの診断・ 血中マーカーによる診断と呼気診断の最前線

    小野島大介、馬場嘉信

    ライフライン21 がんの先進医療   ( 15 ) page: 46-48   2014.10

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  344. A MILLISECOND MICRO-RNA EXTRACTION TECHNIQUE FOR NANOPORE-BASED NUCLEIC ACID SEQUENCING Reviewed

    Qiong Wu, Takao Yasui, Sakon Rahong, Takeshi Yanagida, Masaki Kanai, Noritada Kaji, Manabu Tokeshi, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

    MicroTAS 2014     page: 233-235   2014.10

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  345. SIZING AND SORTING OF SINGLE DNA MOLECULES BY MICROFLUIDIC MOLECULAR COMBING DEVICE Reviewed

    Daisuke Onoshima, Naoko Kawakita, Daiki Takeshita, Hiroshi Yukawa, and Yoshinobu Baba

    MicroTAS 2014     page: 1775-1777   2014.10

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  346. ADDITIVE MANUFACTURING BASED ON INJECTION MOLDING FOR THREE DIMENSIONAL MICROFLUIDICS Reviewed

    Toyohiro Naito, Makoto Nakamura, Takuya Kubo, Takao Yasui, Noritada Kaji, Yoshinobu Baba and Koji Otsuka

    MicroTAS 2014     page: 1686-1688   2014.10

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  347. MICROFLUIDIC STRETCHING OF DNA WITH FLUORESCENT GOLD NANOPARTICLE FOR OPTICAL/ELECTRON MICROSCOPIC IMAGING OF A SINGLE DNA METHYLATION Reviewed

    Daiki Takeshita, Daisuke Onoshima, Yukawa Hiroshi, Takao Yashui, Noritada Kaji and Yoshinobu Baba

    MicroTAS 2014     page: 2348-2350   2014.10

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  348. DEVELOPMENT OF IMMUNO-WALL DEVICES AND A MOBILE FLUORESCENCE READER FOR ON-SITE SAMPLE-TO-ANSWER IMMUNOASSAY Reviewed

    Toshihiro Kasama, Yutaka Hasegawa, Haruyasu Kondo, Tsutomu Ozawa, Noritada Kaji, Manabu Tokeshi and Yoshinobu Baba

    MicroTAS 2014     page: 935-937   2014.10

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  349. QUANTITATIVE EVALUATION OF INSULATING PERFORMANCE ON SILICON NANOBIODEVICES FOR FULLY INTEGRATED NANOPORE SINGLE DNA SEQUENCING Reviewed

    Mamiko Sano, Takao Yasui, Noritada Kaji, Masateru Taniguchi, Tomoji Kawai, Yoshinobu Baba

    MicroTAS 2014     page: 1479-1481   2014.10

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  350. MICROPORE CHANELL-BASED SIMULTANEOUS ELECTRICAL AND OPTICAL SENSING FROM SINGLE BIOMOLECULES, SINGLEEXOSOMES TO SINGLE CELLS Reviewed

    Hirotoshi Yasaki, Takao Yasui, Sakon Rahong, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

    MicroTAS 2014     page: 2161-2163   2014.10

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  351. GEOMETRICAL CONTROL OF A SINGLE DNA MOLECULE TRANSLOCATION VELOCITY IN NANOPORE CHANNELS Reviewed

    Xiaoyin Sun, Takao Yasui, Sakon Rahong, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai and Yoshinobu Baba

    MicroTAS 2014     page: 1338-1340   2014.10

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  352. ULTRAFAST SEPARATION OF SMALL BIOMOLECULES BY THREE-DIMENSIONAL NANOWIRE STRUCTURE Reviewed

    Sakon Rahong, Takao Yasui, Takeshi Yanagida, Masaki Kanai, Kazuki Nagashima, Noritada Kaji, Tomoji Kawai and Yoshinobu Baba

    MicroTAS 2014     page: 2432-2434   2014.10

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  353. EXOSOMAL MEMBRANE PROTEIN DETECTION BY NANOWIRE DEVICE Reviewed

    Yuki Konakade, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Yong He, Masaki Kanai, Kazuki Nagashima, Hiroshi Yukawa, Tomoji Kawai, Yoshinobu Baba

    MicroTAS 2014     page: 2017-2019   2014.10

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  354. EXOSOMAL MICRO-RNA ANALYSIS IN URINE OR SERUM USING NANOWIRE STRUCTURES Reviewed

    Takao Yasui, Satoru Ito, Takeshi Yanagida, Yong He, Sakon Rahong, Masaki Kanai, Kazuki Nagashima, Hiroshi Yukawa, Noritada Kaji, Tomoji Kawai and Yoshinobu Baba

        page: 680-682   2014.10

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  355. Nanobiodevices for Single DNA and Cell Analysis Reviewed

    N. Kaji, Y. Baba

    Micro Total Analysis Systems 2014     page: 264-266   2014.10

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  356. ADDITIVE MANUFACTURING BASED ON INJECTION MOLDING FOR THREE DIMENSIONAL MICROFLUIDICS Reviewed

    Toyohiro Naito, Makoto Nakamura, Takuya Kubo, Takao Yasui, Noritada Kaji, Yoshinobu Baba, Koji Otsuka

    MicroTAS 2014     page: 1686-1688   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  357. SIZING AND SORTING OF SINGLE DNA MOLECULES BY MICROFLUIDIC MOLECULAR COMBING DEVICE Reviewed

    Daisuke Onoshima, Naoko Kawakita, Daiki Takeshita, Hiroshi Yukawa, Yoshinobu Baba

    MicroTAS 2014     page: 1775-1777   2014.10

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  358. Microfluidic transfer of liquid interface for parallel stretching and stamping of terminal-unmodified single DNA molecules between zigzag-shaped microgrooves Reviewed

    Hirotoshi Yasaki, Daisuke Onoshima, Takao Yasui, Hiroshi Yukawa, Notitada Kaji, and Yoshinobu Baba

    Lab on a Chip     page: DOI   2014.9

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    DOI: 10.1039/C4LC00990H

  359. Nanobiodebice-based single biomolecule analysis, single-cell analysis, and in vivo imaging for cancer diagnosis, cancer theranostics, and iPS cell-based regenerative medicine Reviewed

    N. Kaji, Y. Baba

    Anal. Sci.   Vol. 30   page: 859-864   2014.9

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  360. Nanobiodevice-based Single Biomolecule Analysis, Single-Cell Analysis, and in vivo Imaging for Cancer Diagnosis, Cancer Theranostics, and iPS Cell-based Regenerative Medicine

    Kaji Noritada, Baba Yoshinobu

    ANALYTICAL SCIENCES   Vol. 30 ( 9 ) page: 859-864   2014.9

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    Web of Science

  361. Rhinorrhea in Parkinson's disease: A consecutive multicenter study in Japan

    Kano O.

    Journal of the Neurological Sciences   Vol. 343 ( 1-2 ) page: 88-90   2014.8

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    DOI: 10.1016/j.jns.2014.05.039

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  362. ここまで進んだがんの診断・ 血中循環がん細胞の最新検出技術

    笠間敏博、馬場嘉信

    ライフライン21 がんの先進医療   Vol. 14   page: 44-46   2014.7

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  363. ナノ流路を用いた単一分子解析技術 Reviewed

    加地範匡、安井隆雄、馬場嘉信

    ぶんせき   ( 7 ) page: 348-354   2014.7

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    DOI: n/a

  364. Ultrafast and Wide Range Analysis of DNA Molecules Using Rigid Network Structure of Solid Nanowires Reviewed

    Sakon Rahong, Takao Yasui, Takeshi Yanagida, Kazuki Nagashima, Masaki Kanai, Annop Klamchuen, Gang Meng, Yong He, Fuwei Zhuge, Noritada Kaji, Tomoji Kawai & Yoshinobu Baba

    Scientific Reports   Vol. 4   page: 5252   2014.6

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    DOI: 10.1038/srep05252

  365. Synthesis and Reactions of Ynolates via a Stop-Flow Method with a Flow Microreactor Reviewed

    Toshiya Yoshiiwa,Satoshi Umezu,Manabu Tokeshi,Yoshinobu Baba and Mitsuru Shindo

    J. Flow Chem.     page: 10.1556/JFC-D-14-00008   2014.6

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    DOI: 10.1556/JFC-D-14-00008

  366. ナノバイオデバイスによるエクソソーム解析 Reviewed

    湯川博、安井隆雄、馬場嘉信

      Vol. 6   page: n/a   2014.5

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    DOI: n/a

  367. Quantum Dot Reviewed

      Vol. 13 ( 2 ) page: 168-169   2014.5

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  368. がん早期診断の最前線 Reviewed

    湯川博、馬場嘉信

    ライフライン21 がんの先進医療   Vol. 13   page: 31-34   2014.4

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    DOI: 31-34

  369. Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes Reviewed

    Yasuhiro Hayashi, Erina Suemitsu, Kazuaki Kajimoto, Yusuke Sato, Afsana Akhter, Erina Suemitsu, Yu Sakurai, Hiroto Hatakeyama, Mamoru Hyodo, Noritada Kaji, Yoshinobu Baba, and Hideyoshi Harashima

    Mol. Ther., Nucleic Acids   Vol. 3   page: e154   2014.3

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    DOI: 10.1038/mtna.2014.4.

  370. Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes Reviewed

    Yasuhiro Hayashi, Erina Suemitsu, Kazuaki Kajimoto, Yusuke Sato, Afsana Akhter, Erina Suemitsu, Yu Sakurai, Hiroto Hatakeyama, Mamoru Hyodo, Noritada Kaji, Yoshinobu Baba, and Hideyoshi Harashima

      Vol. 4   page: 5252   2014.3

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    DOI: 10.1038/srep05252

  371. Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes

    Hayashi Yasuhiro, Suemitsu Erina, Kajimoto Kazuaki, Sato Yusuke, Akhter Afsana, Sakurai Yu, Hatakeyama Hiroto, Hyodo Mamoru, Kaji Noritada, Baba Yoshinobu, Harashima Hideyoshi

    MOLECULAR THERAPY-NUCLEIC ACIDS   Vol. 3   page: e154   2014.3

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    DOI: 10.1038/mtna.2014.4

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  372. On-Chip Analysis of Intermittent Molecular Encounters in Nuclease Digestion of Specific DNA Sequence

    Onoshima Daisuke, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    BIOPHYSICAL JOURNAL   Vol. 106 ( 2 ) page: 699A-699A   2014.1

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    Web of Science

  373. Microfluidic biosensor for the detection of DNA by fluorescence enhancement and the following streptavidin detection by fluorescence quenching

    Wang Jun, Aki Michihiko, Onoshima Daisuke, Arinaga Kenji, Kaji Noritada, Tokeshi Manabu, Fujita Shozo, Yokoyama Naoki, Baba Yoshinobu

    BIOSENSORS & BIOELECTRONICS   Vol. 51   page: 280 - 5   2014.1

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    DOI: 10.1016/j.bios.2013.07.058

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  374. Nationwide post event survey and analysis of the 2011 Tohoku earthquake tsunami

    Mori N.

    Coastal Engineering Journal   Vol. 54 ( 1 )   2014.1

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    DOI: 10.1142/S0578563412500015

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  375. 量子ドットイメージング Reviewed

    湯川博、馬場嘉信

    Organ Biology   Vol. 21   page: 237-240   2014

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    DOI: n/a

  376. Novel positively charged nanoparticle labeling for in vivo imaging of adipose tissue-derived stem cells Reviewed

    Hiroshi Yukawa a, Shingo Nakagawa b, Yasuma Yoshizumi b, Masaki Watanabe c, Hiroaki Saito d, Yoshitaka Miyamoto e, Hirofumi Noguchi f, Koichi Oishi g, Kenji Ono g, Makoto Sawada g, Ichiro Kato d, Daisuke Onoshima h, Momoko Obayashi a, Yumi Hayashi b, Noritada Kaji a, c, Tetsuya Ishikawa b, Shuji Hayashi e, Yoshinobu Baba a, b, i

    PLOS ONE     page: DOI   2014

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    DOI: DOI

  377. Novel Positively Charged Nanoparticle Labeling for In Vivo Imaging of Adipose Tissue-Derived Stem Cells

    Hiroshi Yukawa, Shingo Nakagawa, Yasuma Yoshizumi, Masaki Watanabe, Hiroaki Saito, Yoshitaka Miyamoto, Hirofumi Noguchi, Koichi Oishi, Kenji Ono, Makoto Sawada, Ichiro Kato, Daisuke Onoshima, Momoko Obayashi, Yumi Hayashi, Noritada Kaji, Tetsuya Ishikawa, Shuji Hayashi, Yoshinobu Baba

    PLOS ONE   Vol. 9 ( 11 ) page: e110142   2014

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    Stem cell transplantation has been expected to have various applications for regenerative medicine. However, in order to detect and trace the transplanted stem cells in the body, non-invasive and widely clinically available cell imaging technologies are required. In this paper, we focused on magnetic resonance (MR) imaging technology, and investigated whether the trimethylamino dextran-coated magnetic iron oxide nanoparticle -03 (TMADM-03), which was newly developed by our group, could be used for labeling adipose tissue-derived stem cells (ASCs) as a contrast agent. No cytotoxicity was observed in ASCs transduced with less than 100 mu g-Fe/mL of TMADM-03 after a one hour transduction time. The transduction efficiency of TMADM-03 into ASCs was about four-fold more efficient than that of the alkali-treated dextran-coated magnetic iron oxide nanoparticle (ATDM), which is a major component of commercially available contrast agents such as ferucarbotran (Resovist), and the level of labeling was maintained for at least two weeks. In addition, the differentiation ability of ASCs labeled with TMADM-03 and their ability to produce cytokines such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2), were confirmed to be maintained. The ASCs labeled with TMADM-03 were transplanted into the left kidney capsule of a mouse. The labeled ASCs could be imaged with good contrast using a 1T MR imaging system. These data suggest that TMADM-03 can therefore be utilized as a contrast agent for the MR imaging of stem cells.

    DOI: 10.1371/journal.pone.0110142

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  378. Nanobiodevice-based single biomolecule analysis, single-cell analysis, and in vivo imaging for cancer diagnosis, cancer theranostics, and iPS cell-based regenerative medicine.

    Kaji N, Baba Y

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 30 ( 9 ) page: 859-64   2014

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    DOI: 10.2116/analsci.30.859

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    CiNii Article

  379. Influence of cryopreservation of exosomes derived from liver cancer cells on angiogenic potency

    Yukawa Hiroshi, Baba Yoshinobu

    Organ Biology   Vol. 21 ( 2 ) page: 237-240   2014

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    In this study, we herein examined the effects of the exosomes secreted from a stable hepatocellular carcinoma (HCC) cell line (HCC-exosomes) on the lumen formation of human umbilical vein endothelial cells(HUVECs). The uptake of HCC-exosomes by HUVECs and lumen formation by the HUVECs that included the exosomes were observed. The degree of lumen formation of HUVECs was dependent on the number of the HCC-exosomes. HCC-exosomes expressed a stress-induced heat shock protein associated with angiogenesis through the vascular endothelial growth factor(VEGF)receptor. In addition, the exosomes contained several microRNAs (miRNAs)reported to exist in the serum of HCC patients. The changes in the expression levels of miRNAs associated with angiogenesis were detected in the HUVECs treated with HCC-exosomes. Moreover, the abilities of the exosomes maintained after the treatment of cryopreservation. These results suggest that the HCC-exosomes play an important role in the angiogenesis. Further studies on the function of HCC-exosomes may provide a new target for HCC treatment.

    DOI: 10.11378/organbio.21.237

    CiNii Article

  380. Induced Pluripotent Stem Cell Labeling Using Quantum Dots

    Hiroshi Yukawa, Kaoru Suzuki, Yuki Kano, Tatsuya Yamada, Noritada Kaji, Tetsuya Ishikawa, and Yoshinobu Baba

    Cell Medicine   Vol. 6 ( 1-2 ) page: 83 - 90   2013.12

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    DOI: 10.3727/215517913X674270

    PubMed

  381. Adipose Tissue-Derived Stem Cell Imaging Using Cadmium-Free Quantum Dots

    Yoshiyuki Miyazaki, Hiroshi Yukawa, Hiroyasu Nishi, Yukihiro Okamoto, Noritada Kaji, Tsukasa Torimoto, and Yoshinobu Baba

    Cell Medicine   Vol. 6 ( 1-2 ) page: 91 - 7   2013.12

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    DOI: 10.3727/215517913X674261

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  382. Reduced Plasma Glucose by Asparagine Synthetase Knockdown in the Mouse Liver

    Iida Shinya, Kamiya Hiroyuki, Nakaya Akihiro, Hayashi Yasuhiro, Sawada Akihiro, Kaji Noritada, Baba Yoshinobu, Harashima Hideyoshi

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 36 ( 12 ) page: 2009-2011   2013.12

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    Web of Science

  383. Observation of Positively Charged Magnetic Nanoparticles Inside HepG2 Spheroids Using Electron Microscopy

    Yoshitaka Miyamoto, Yumie Koshidaka, Hirofumi Noguchi, Koichi Oishi, Hiroaki Saito, Hiroshi Yukawa, Noritada Kaji, Takeshi Ikeya, Satoshi Suzuki, Hisashi Iwata, Yoshinobu Baba, Katsutoshi Murase, Shuji Hayashi

    Cell Medicine   Vol. 5 ( 2-3 ) page: 89 - 96   2013.11

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    DOI: 10.3727/215517913X666530

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  384. A DNA microarray-based analysis of immune-stimulatory and transcriptional responses of dendritic cells to KALA-modified nanoparticles International journal

    Akita Hidetaka, Ishii Soichiro, Miura Naoya, Shaheen Sharif Mohammad, Hayashi Yasuhiro, Nakamura Takashi, Kaji Noritada, Baba Yoshinobu, Harashima Hideyoshi

    BIOMATERIALS   Vol. 34 ( 35 ) page: 8979 - 90   2013.11

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    DOI: 10.1016/j.biomaterials.2013.08.003

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  385. Induced Pluripotent Stem Cell Labeling Using Quantum Dots Reviewed

    Hiroshi Yukawa, Kaoru Suzuki, Yuki Kano, Tatsuya Yamada, Noritada Kaji, Tetsuya Ishikawa, and Yoshinobu Baba

    Cell Medicine   Vol. 6   page: 83-90   2013.10

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  386. Adipose Tissue-Derived Stem Cell Imaging Using Cadmium-Free Quantum Dots Reviewed

    Yoshiyuki Miyazaki, Hiroshi Yukawa, Hiroyasu Nishi, Yukihiro Okamoto, Noritada Kaji, Tsukasa Torimoto, and Yoshinobu Baba

    Cell Medicine   Vol. 6   page: 91-97   2013.10

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  387. MICROFLUIDIC PARALLEL STRETCHING AND STAMPING OF SINGLE DNA MOLECULES FOR SUPER RESOLUTION MICROSCOPE IMAGING Reviewed

    Hirotoshi Yasaki, Daisuke Onoshima, Takao Yasui, Toyohiro Naito, Noritada Kaji, and Yoshinobu Baba

    Micro Total Analysis Systems 2013     page: 88-90   2013.10

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    DOI: 88-90

  388. DEVELOPMENT OF 3RD GENERATION IMMUNO-PILLAR DEVICE FOR HIGH SENSITIVE DETECTION OF DISEASE MARKERS Reviewed

    N. Nishiwaki, T. Kasama, A. Ishida, H. Tani, Y. Baba, M. Tokeshi

    Micro Total Analysis Systems 2013     page: 1164-1166   2013.10

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    DOI: 1164-1166

  389. CHRISTMAS-TREE NANOWIRE CHIPS FOR DNA SEPARATION Reviewed

    Sakon Rahong, Takao Yasui, Takeshi Yanagida, Masaki Kanai, Kazuki Nagashima, Annop Klamchuen, Meng Gang, He Yong, Fuwei Zhuge, Noritada Kaji, Yoshinobu Baba and Tomoji Kawai

    Micro Total Analysis Systems 2013     page: 164-166   2013.10

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  390. NANOWIRE DEVICES FOR EXOSOMAL MICRORNA EXTRACTION Reviewed

    Satoru Ito, Takao Yasui, He Yong, Takeshi Yanagida, Sakon Rahong, Masaki Kanai, Kazuki Nagashima, Hiroshi Yukawa, Noritada Kaji, Tomoji Kawai, Yoshinobu Baba

    Micro Total Analysis Systems 2013     page: 1887-1889   2013.10

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    DOI: 1887-1889

  391. LABAL-FREE DETECTION AND QUANTIFICATION OF REAL-TIME DNA AMPLIFICATION USING ONE-DIMENSIONAL PHOTONIC CRYSTAL

    Takao Yasui, Kensuke Ogawa, Noritada Kaji, Mats Nilsson, Manabu Tokeshi, Yasuhiro Horiike, and Yoshinobu Baba

    Micro Total Analysis Systems 2013     page: 1123-1125   2013.10

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    DOI: 1123-1125

  392. SINGLE DNA MOLECULE EXTRACTION FROM SINGLE BACTERIUM USING NANOWIRE STRUCTURES

    Kouhei Ootsuka, Takao Yasui, Noritada Kaji, Sakon Rahong, Takeshi Yanagida, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai and Yoshinobu Baba

    Micro Total Analysis Systems 2013     page: 479-481   2013.10

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    DOI: 479-481

  393. MICROFLUIDIC SINGLE-MOLECULE NUCLEASE DIGESTION REVEALS RATE-ENHANCING OFF-AND-ON MOLECULAR ENCOUNTERING FUNCTION FOR SITE-SPECIFIC DNA BREAK Reviewed

    Daisuke Onoshima, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

    Micro Total Analysis Systems 2013     page: 820-822   2013.10

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    DOI: 820-822

  394. HIGH THROUGHPUT PURIFICATION DEVICES FOR IN VIVO APPLICATIONS OF GENEDELIVERY MULTIFUNCTIONAL EVELOPE-TYPE NANODEVICES Reviewed

    Noritada Kaji, Daisuke Shigenaka, Masami Ukawa, Manabu Tokeshi, Hidetaka Akita, Hideyoshi Harashima and Yoshinobu Baba

    Micro Total Analysis Systems 2013     page: 1170-1172   2013.10

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    DOI: 1170-1172

  395. CONTROL OF DNA TRANSLOCATION VELOCITIES FOR NANOPORE-BASED DNA SEQUENCING Reviewed

    Xiaoyin Sun, Takao Yasui, Sakon Rahong, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai and Yoshinobu Baba

    Micro Total Analysis Systems 2013     page: 1117-1119   2013.10

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    DOI: 1117-1119

  396. HIGH-SPEED MICRO-RNA ISOLATION FROM DNA FRAGMENTS BY NANOPILLER ARRAY CHIP Reviewed

    .Qiong Wu, Takao Yasui, Sakon Rahong, Takeshi Yanagida, Masaki Kanai, Noritada Kaji, Manabu Tokeshi, Kazuki Nagashima, Tomoji Kawai, and Yoshinobu Baba

    Micro Total Analysis Systems 2013     page: 1206-1208   2013.10

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    DOI: 1206-1208

  397. DNA METHYLATION MAPPING IN NANOSLIT DEVICES AT A SINGLE MOLECULE LEVELMicro Total Analysis Systems 2013, 2013, 29-31. Reviewed

    Mayu Mizutani, Takao Yasui, Kasama Toshihiro, Nortada Kaji, Yoshinobu Baba

    Micro Total Analysis Systems 2013     page: 29-31   2013.10

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    DOI: 29-31

  398. Direct conversion of silver complexes to nanoscale hexagonal columns on a copper alloy for plasmonic applications

    Yamamoto Yuko S., Hasegawa Katsuyuki, Hasegawa Yuuki, Takahashi Naoshi, Kitahama Yasutaka, Fukuoka Satoshi, Murase Norio, Baba Yoshinobu, Ozaki Yukihiro, Itoh Tamitake

    PHYSICAL CHEMISTRY CHEMICAL PHYSICS   Vol. 15 ( 35 ) page: 14611 - 5   2013.9

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    DOI: 10.1039/c3cp52564c

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  399. Visualization of Two-Dimensional Excitation Temperatures in CH4/N2/Ar Plasmas for Preparation of Carbonaceous Materials Reviewed

    Qingchun Shen, Yasushi Miyata, Shigeaki Morita, Yoshinobu Baba, Kuniyuki Kitagawa and Ashwani K. Gupta

    Journal of Energy Resources Technology   Vol. 135 ( 3 ) page: 034501-1,2, 3   2013.9

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    DOI: 10.1115/1.4023744

  400. Microfluidic biosensor for the detection of DNA by fluorescence enhancement and the following streptavidin detection by fluorescence quenching

    Jun Wang, Michihiko Aki, Daisuke Onoshima, Kenji Arinag Noritada Kaji Manabu Tokeshi,Shozo Fujita, Naoki Yokoyama, and Yoshinobu Baba

    Biosensors and Bioelectronics   ( 5 ) page: 280-285   2013.8

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  401. High speed DNA denaturation using microheating devices International journal

    Furuhashi Masayuki, Okamoto Yukihiro, Onoshima Daisuke, Ohshiro Takahito, Ryuzaki Sou, Yokota Kazumichi, Tsutsui Makusu, Taniguchi Masateru, Nakatani Kazuhiko, Baba Yoshinobu, Kawai Tomoji

    APPLIED PHYSICS LETTERS   Vol. 103 ( 2 )   2013.7

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    DOI: 10.1063/1.4813552

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  402. Plasmonic staining of DNA molecules with photo-induced Ag nanoparticles monitored using dark-field microscopy International journal

    Yamamoto Yuko S., Hirano Ken, Ishido Tomomi, Yasui Takao, Murase Norio, Baba Yoshinobu, Itoh Tamitake

    PHYSICAL CHEMISTRY CHEMICAL PHYSICS   Vol. 15 ( 25 ) page: 10316 - 20   2013.7

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    DOI: 10.1039/c3cp51494c

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  403. High speed DNA denaturation using microheating devices Reviewed

    M. Furuhashi, Y. Okamoto, D. Onoshima, T. Ohshiro, S. Ryuzaki, K. Yokota, M. Tsutsui, M. Taniguchi, K. Nakatani, Y. Baba, T. Kawai

    Applied Physics Letters   Vol. 103 ( 2 ) page: 023112-1,2,3,4   2013.7

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  404. Nanopillar Array Chip Integrated with On-line Stacking for Fast DNA Separation with High Sensitivity and High Resolution

    Takao Yasuia, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, Yasuhiro Horiike, and Yoshinobu Baba

    Micro & Nanofluidicis   Vol. 14 ( 6 ) page: 961 - 967   2013.6

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    DOI: 10.1007/s10404-012-1103-7

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  405. Nanobiodevices for Biomolecule Analysis and Imaging

    T. Yasui, N. Kaji, Y. Baba

    Annual Review of Analytical Chemistry   Vol. 6   page: 83-96   2013.6

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  406. Application of IgY to ELISA, LFDs, and immunopillar chips for detecting staphylococcal enterotoxins in milk and dairy products

    Jin W., Yamada K., Ikami M., Kaji N., Tokeshi M., Atsumi Y., Mizutani M., Murai A., Okamoto A., Namikawa T., Baba Y., Ohta M.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 42   page: S46-S47   2013.6

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  407. Plasmonic Imaging of Brownian Motion of Single DNA Molecules Spontaneously Binding to Ag Nanoparticles

    Hirano Ken, Ishido Tomomi, Yamamoto Yuko S., Murase Norio, Ichikawa Masatoshi, Yoshikawa Kenichi, Baba Yoshinobu, Itoh Tamitake

    NANO LETTERS   Vol. 13 ( 5 ) page: 1877 - 82   2013.5

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    DOI: 10.1021/nl304247n

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  408. Pretreatment Methods for Selections Lung Cancer Markers in Mouse Urine

    HANAI Yosuke, BABA Yoshinobu

    BUNSEKI KAGAKU   Vol. 62 ( 5 ) page: 437 - 442   2013.5

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    Lung cancer is a leading cause of cancer-related deaths. Hence, developing early stage diagnostic tests that are highly sensitive and specific is crucial. In order to achieve a desirable preventive medicine in the future, a non-invasive diagnostic technique with a volatile biomarker is a key. In this work, we compared VOCs obtained from the urine of tumor-bearing mice and normal control mice, and found 21 VOCs to be candidate biomarkers for lung cancer. To more efficiently extract the candidate biomarkers, we tested five different pretreatment methods. Among these the most improved extraction efficiency was the addition of sodium chloride along with a heat treatment.

    DOI: 10.2116/bunsekikagaku.62.437

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  409. マウス尿中肺がんマーカー候補選定のための前処理法 Reviewed

    分析化学   Vol. 62 ( 5 ) page: 437-442   2013.5

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  410. Plasmonic staining of DNA molecules with photo-induced Ag nanoparticles monitored using dark-field microscopy Reviewed

    Y.S. Yamamoto, K. Hirano, T. Ishido, T. Yasui, N. Murase, Y. Baba

    Physical Chemistry Chemical Physics   Vol. 15 ( 25 ) page: 10316-10320   2013.5

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  411. Plasmonic Imaging of Brownian Motion of Single DNA Molecules Spontaneously Binding to Ag Nanoparticles Reviewed

    K. Hirano, T. Ishido, Y.S. Yamamoto, N. Murase, M. Ichikawa, K. Yoshikawa, Y. Baba

    Nano Lett.   Vol. 13 ( 5 ) page: 1877-1882   2013.5

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  412. Nano Packagingが拓く次世代核酸医療 Reviewed

    松尾保隆、加地範匡、畠山浩人、渡慶次学、小暮健太朗、馬場嘉信、原島秀吉

    表面   Vol. 51   page: 227-240   2013.5

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    DOI: 227-240

  413. Pretreatment Methods for Selections Lung Cancer Markers in Mouse Urine

    Hanai Yosuke, Baba Yoshinobu

    BUNSEKI KAGAKU   Vol. 62 ( 5 ) page: 437-442   2013.5

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  414. Nanobiotechnology meets plant cell biology: carbon nanotubes as organelle targeting nanocarriers

    Serag Maged F., Kaji Noritada, Habuchi Satoshi, Bianco Alberto, Baba Yoshinobu

    RSC ADVANCES   Vol. 3 ( 15 ) page: 4856 - 4862   2013.4

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    DOI: 10.1039/c2ra22766e

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  415. A Method for Screening Lung Cancer Samples for Volatile, Organic Urinary Compounds as Biomarkers for Lung Cancer Using Solid-Phase Microextraction and Gas Chromatography Time-of-Flight Mass Spectrometry

    HANAI Yosuke, BABA Yoshinobu

    Journal of the Mass Spectrometry Society of Japan   Vol. 61 ( 2 ) page: 13-21   2013.4

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    Of all types of cancers, lung cancer is the primary cause of mortality. To reduce the high mortality rate, development of sensitive and specific techniques for the early diagnosis of lung cancer would be highly desirable. For preventive medicine in the future, one of the key technologies is a non-invasive diagnostic technique for identifying volatile biomarkers. In this work, volatile organic compounds (VOCs) derived from urine were extracted by solid phase micro extraction (SPME) and analyzed by gas chromatography time-of-flight mass spectrometer (GC-TOF MS). We compared the VOCs obtained from the urine of the tumor-bearing mice with the corresponding compounds from normal control mice. In order to detect volatile biomarkers for lung cancer more efficiently, we examined five different pretreatment methods for the extraction of VOCs by SPME, and finally were able to identify some potential candidate biomarkers for lung cancer.

    DOI: 10.5702/massspec.12-49

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  416. Nanobiotechnology meets plant cell biology: carbon nanotubes as organelle targeting nanocarriers Reviewed

    M.F. Serag, N. Kaji, S. Habuchi, A. Bianco, Y. Baba

    RSC Advances   Vol. 3 ( 15 ) page: 4856-4862   2013.4

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  417. DNA Manipulation and Separation in Sublithographic-Scale Nanowire Array Reviewed

    T. Yasui, S. Rahong, K. Motoyama, T. Yanagida, Q. Wu, N. Kaji, M. Kanai, K. Doi, K. Nagashima, M. Tokeshi, M. Taniguchi, S. Kawano, T. Kawai, Y. Baba

    ACS Nano   Vol. 7 ( 4 ) page: 3029-3035   2013.4

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  418. SPME GC-TOF MSを用いた肺がん識別のため尿中揮発性有機化合物のスクリーニング法の検討 Reviewed

    花井陽介, 馬場嘉信

    質量分析学会誌   Vol. 61 ( 2 ) page: 13-21   2013.4

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  419. DNA Manipulation and Separation in Sublithographic-Scale Nanowire Array

    Yasui Takao, Rahong Sakon, Motoyama Koki, Yanagida Takeshi, Wu Qiong, Kaji Noritada, Kanai Masaki, Doi Kentaro, Nagashima Kazuki, Tokeshi Manabu, Taniguchi Masateru, Kawano Satoyuki, Kawai Tomoji, Baba Yoshinobu

    ACS NANO   Vol. 7 ( 4 ) page: 3029-3035   2013.4

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    DOI: 10.1021/nn4002424

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  420. Application of IgY to sandwich enzyme-linked immunosorbent assays, lateral flow devices, and immunopillar chips for detecting staphylococcal enterotoxins in milk and dairy products Reviewed

    W.C. Jin, K. Yamada, M. Ikami, N. Kaji, M. Tokeshi, Y. Atsumi, M. Mizutani, A. Murai, A. Okamoto, T. Namikawa, Y. Baba, M. Ohta

    Journal of Microbiological Methods   Vol. 92 ( 3 ) page: 323-331   2013.3

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  421. ナノバイオデバイスが拓く未来ヘルスケアとバイオセンサへの展開

    馬場嘉信

    月刊ディスプレイ   Vol. 19 ( 3 ) page: 1-8   2013.3

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  422. Parallel Real-Time PCR on a Chip for Genetic Tug-of-War (gTOW) Method Reviewed

    T. Naito, A. Yatsuhashi, N. Kaji, T. Ando, K. Sato, H. Moriya, H. Kitano, T. Yasui, M. Tokeshi, Y. Baba

    Analytical Sciences   Vol. 29 ( 3 ) page: 367-371   2013.3

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  423. Enzyme-catalysed reaction for long-term fluorescent observation of single DNA molecules Reviewed

    T. Yasui, K. Motoyma, N. Kaji, M. Tokeshia, Y. Baba

    RSC Adv.   Vol. 3 ( 10 ) page: 3237–3240   2013.3

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  424. Application of IgY to sandwich enzyme-linked immunosorbent assays, lateral flow devices, and immunopillar chips for detecting staphylococcal enterotoxins in milk and dairy products International journal

    Jin Wanchun, Yamada Keiko, Ikami Mai, Kaji Noritada, Tokeshi Manabu, Atsumi Yusuke, Mizutani Makoto, Murai Atsushi, Okamoto Akira, Namikawa Takao, Baba Yoshinobu, Ohta Michio

    JOURNAL OF MICROBIOLOGICAL METHODS   Vol. 92 ( 3 ) page: 323 - 31   2013.3

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    DOI: 10.1016/j.mimet.2013.01.001

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  425. Parallel Real-Time PCR on a Chip for Genetic Tug-of-War (gTOW) Method

    Naito Toyohiro, Yatsuhashi Ai, Kaji Noritada, Ando Taeko, Sato Kazuo, Moriya Hisao, Kitano Hiroaki, Yasui Takao, Tokeshi Manabu, Baba Yoshinobu

    ANALYTICAL SCIENCES   Vol. 29 ( 3 ) page: 367-371   2013.3

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  426. Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices

    Naito Toyohiro, Arayanarakool Rerngchai, Le Gac Severine, Yasui Takao, Kaji Noritada, Tokeshi Manabu, van den Berg Albert, Baba Yoshinobu

    LAB ON A CHIP   Vol. 13 ( 3 ) page: 452 - 8   2013.2

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    DOI: 10.1039/c2lc41030c

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  427. Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices Reviewed

    T. Naito, R. Arayanarakool, S. Le Gac, T. Yasui, N. Kaji, M. Tokeshi, A. van den Berg, Y. Baba

    Lab on a Chip   Vol. 13 ( 3 ) page: 452-458   2013.2

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  428. 血中循環がん細胞(CTC)検出によるがん診断

    岡本行広, 馬場嘉信

    現代化学   Vol. 504   page: 32-36   2013.2

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  429. 進展する早期がん診断の研究

    馬場嘉信

    現代化学   Vol. 504   page: 21-23   2013.2

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  430. カーボンナノチューブによる植物細胞への遺伝子導入

    馬場嘉信

    VBLニュース   Vol. 17 ( 2 ) page: 4   2013.2

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  431. Simultaneous Immunoassay Analysis of Plasma IL-6 and TNF-alpha on a Microchip Reviewed

    K. Abe, Y. Hashimoto, S. Yatsushiro, S. Yamamura, M. Bando, Y. Hiroshima, J. Kido, M. Tanaka, Y. Shinohara, T. Ooie, Y. Baba, M. Kataoka

    PLoS One   Vol. 8 ( 1 ) page: 8   2013.1

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  432. A DNA microarray-based analysis of immune-stimulatory and transcriptional responses of dendritic cells to KALA-modified nanoparticles Reviewed

    H. Akita, S. Ishii, N. Miura, S.M. Shaheen, Y. Hayashi, T. Nakamura, N. Kaji, Y. Baba

    Biomaterials     page: in press   2013

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  433. On-demand Production of Highly Reproducible SERS Substrates Made of Silver Nanohexagonal Columns via Galvanic Displacement Reviewed

    Y.S. Yamamoto, K. Hasegawa, Y. Hasegawa, Y. Kitahama, S. Fukuoka, N. Murase, Y. Baba, Y. Ozaki, T. Itoh

    Physical Chemistry Chemical Physics     page: in press   2013

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  434. Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver Reviewed

    Shinya Iida, Hiroyuki Kamiya, Akihiro Nakaya, Yasuhiro Hayashi, Akihiro Sawada, Noritada Kaji, Yoshinobu Baba and Hideyoshi Harashima

    Biol. Pharm. Bull., in press     page: -   2013

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  435. Enzyme-catalysed reaction for long-term fluorescent observation of single DNA molecules

    Yasui Takao, Motoyama Koki, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    RSC ADVANCES   Vol. 3 ( 10 ) page: 3237-3240   2013

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    DOI: 10.1039/c3ra22999h

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  436. ESTABLISHMENT OF PORTABLE IMMUNOASSAY SYSTEM FOR EARLY DIAGNOSIS

    Kasama Toshihiro, Hasegawa Yutaka, Matsumoto Hiroyuki, Kondo Haruyasu, Ozawa Tsutomu, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    2013 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS)     page: .   2013

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  437. Nanobiodevices for Biomolecule Analysis and Imaging International journal

    Yasui Takao, Kaji Noritada, Baba Yoshinobu

    ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 6   Vol. 6   page: 83 - 96   2013

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    DOI: 10.1146/annurev-anchem-062012-092619

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  438. Parallel real-time PCR on a chip for genetic tug-of-war (gTOW) method.

    Naito T, Yatsuhashi A, Kaji N, Ando T, Sato K, Moriya H, Kitano H, Yasui T, Tokeshi M, Baba Y

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 29 ( 3 ) page: 367 - 71   2013

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    DOI: 10.2116/analsci.29.367

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  439. Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver.

    Iida S, Kamiya H, Nakaya A, Hayashi Y, Sawada A, Kaji N, Baba Y, Harashima H

    Biological & pharmaceutical bulletin   Vol. 36 ( 12 ) page: 2009-11   2013

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    DOI: 10.1248/bpb.b13-00414

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  440. Simultaneous Immunoassay Analysis of Plasma IL-6 and TNF-alpha on a Microchip

    Abe Kaori, Hashimoto Yoshiko, Yatsushiro Shouki, Yamamura Shohei, Bando Mika, Hiroshima Yuka, Kido Jun-ichi, Tanaka Masato, Shinohara Yasuo, Ooie Toshihiko, Baba Yoshinobu, Kataoka Masatoshi

    PLOS ONE   Vol. 8 ( 1 ) page: e53620   2013

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    DOI: 10.1371/journal.pone.0053620

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  441. 連載 超解像顕微鏡の世界:波長の壁を越えて見る(1)  超解像顕微鏡とは:Abbeの法則への挑戦

    加地範匡、渡慶次学、馬場嘉信

    現代化学   Vol. 1   page: 50-54   2012.12

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    DOI: 50-54

  442. Spatiotemporal Visualization of Subcellular Dynamics of Carbon Nanotubes

    Maged F. Serag, Kevin Braeckmans, Satoshi Habuchi, Noritada Kaji, Alberto Bianco and Yoshinobu Baba

    Nano Letters   Vol. 12 ( 12 ) page: 6145 - 51   2012.12

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    DOI: 10.1021/nl3029625

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  443. ナノバイオデバイスが拓く再生医療研究の新展開

    馬場嘉信

    工学への道     page: in press   2012.12

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  444. ナノバイオデバイスによる単一DNA分子解析技術の最前線

    加地範匡

    化学と工業     page: in press   2012.12

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  445. 30年~50年後に花が咲く研究を

    馬場嘉信

    研究室の窓から     page: in press   2012.12

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  446. A deep microfluidic absorbance detection cell replicated from a thickly stacked SU-8 dry film resist mold Reviewed

    Daisuke Onoshima, Jun Wang, Michihiko Aki, Kenji Arinaga, Noritada Kaji, Manabu Tokeshi, Shozo Fujita, Naoki Yokoyama and Yoshinobu Baba

    Anal. Methods   Vol. 4   page: 4368-4372   2012.12

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    DOI: 10.1039/C2AY26099A

  447. 連載 超解像顕微鏡の世界:波長の壁を超えて見る(1) 超解像顕微鏡とは:Abbeの法則への挑戦

    加地範匡, 渡慶次学, 馬場嘉信

    現代化学   Vol. 502 ( 1 ) page: 50-54   2012.12

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  448. Inkjet Injection of DNA Droplets for Microchannel Array Electrophoresis

    Yasui Takao, Inoue Yosuke, Naito Toyohiro, Okamoto Yukihiro, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    ANALYTICAL CHEMISTRY   Vol. 84 ( 21 ) page: 9282 - 6   2012.11

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    DOI: 10.1021/ac3020565

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  449. Inkjet Injection of DNA droplets for microchannel array electrophoresis Reviewed

    Takao Yasui, Yosuke Inoue, Toyohiro Naito, Yukihiro Okamoto, Noritada Kaji, Manabu Tokeshia, and Yoshinobu Baba

    Anal. Chem.   Vol. 84 ( 21 ) page: 9282-9286   2012.11

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  450. フロントランナーに聞く

    杉本直己, 馬場嘉信, 三原久和, 浜地格, 深瀬浩一

    CSJカレントレビュー10 ここまで進んだバイオセンシング・イメージング ~1分子から細胞、脳まで~     page: 2-9   2012.11

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  451. 量子ドットin vivoイメージング

    馬場嘉信

    CSJカレントレビュー10 ここまで進んだバイオセンシング・イメージング ~1分子から細胞、脳まで~     page: 172-177   2012.11

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  452. 絵解き バイオセンシング・バイオイメージングの基礎

    馬場嘉信

    CSJカレントレビュー10 ここまで進んだバイオセンシング・イメージング ~1分子から細胞、脳まで~     page: 10-14   2012.11

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  453. Single DNA Manipulation in Sublithographic Nanowire Array Chips Reviewed

    Takao Yasui, Sakon Rahong, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kentaro Doi, Manabu Tokeshi, Satoyuki Kawano, Tomoji Kawai, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 228-230   2012.10

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  454. GRAPHENE FOREST DEVICES AS CELL SCAFFOLDS FOR STEM CELLS Reviewed

    Yukihiro Okamoto, Hitoshi Watanabe, Kazutoshi Kubo, Hiroki Kondo, Noritada Kaji, Manabu Tokeshi, Masaru Hori, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 1633-1635   2012.10

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  455. MICROFLUIDIC RARE CANCER CELL COLLECTION WITH ANTI-EpCAM ANTIBODY MODIFIED EUGLENA BY PHOTOTAXIS INSIDE MICROCHANNELS Reviewed

    Yukihiro Okamoto, Yukinori Nakakita, Takahiro Sano, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 1108-1110   2012.10

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  456. IDENTIFICATION OF SINGLE MOLECULAR DNA METHYLATION POINTS BY MICROFLUIDIC DNA MOLECULE STRETCHING AND QUANTUM DOT DETECTION Reviewed

    Yukihiro Okamoto, Tatsuki Sano, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 1939-1941   2012.10

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  457. Fabrication of PMMA Micropillars by Reactive Ion Etching Towards Separation of White and Red Blood Cells Reviewed

    Satoru Ito, Takao Yasui, Yukihiro Okamoto, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 1234-1236   2012.10

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  458. High Throughput Purification Device for Gene Delivery Multifunctional Envelope-Type Nanodevice Reviewed

    Daisuke Shigenaka, Masami Ukawa, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, Hidetaka Akita, Hideyoshi Harashima, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 1546-1548   2012.10

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  459. Detection of Metallic Elements in A Single Cancer Cell Using Microfluidic Devices Coupled With ICP-MS Reviewed

    Yoshiyuki Miyazaki, Takao Yasui, Kazumi Inagaki, Yukihiro Okamoto, Noritada Kaji, Tomonari Umemura, Manabu Tokeshi, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 767-769   2012.10

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  460. DEVELPOEMENT OF NOVEL CIRCULATING TUMOR CELLS SEPARATION AND NON-LABELING DETECTION BY CIRCULATING TUMOR CELLS' SPECIFIC PROPERTIES Reviewed

    Kouhei Ootsuka, Yukihiro Okamoto, Tetsunari Hase, Manabu Tokeshi, Noritada Kaji, Yoshinori Hasegawa, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 1123-1125   2012.10

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  461. On-Chip Electric Power Generation System from Sound of Portable Music Players and Smartphones Toward Portable μTAS Reviewed

    Toyohiro Naito, Noritada Kaji, Severine Le Gac, Manabu Tokeshi, Albert Van Den Berg, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 1852-1854   2012.10

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  462. A Highly Efficient 3D Micromixer Fabricated by Standard Soft-Lithography Equipment Reviewed

    Toyohiro Naito, Rerngchai Arayanarakool, Noritada Kaji, Severine Le Gac, Manabu Tokeshi, Albert Van Den Berg, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 662-664   2012.10

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  463. Sub-Millisecond Separation of DNA and Micro-RNA by Nanopiller Array Chips Reviewed

    Qiong Wu, Takao Yasui, Sakon Rahong, Takeshi Yanagida, Masaki Kanai, Yukihiro Okamoto, Noritada Kaji, Manabu Tokeshi, Tomoji Kawai, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 599-601   2012.10

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  464. Rapid Urine-Based Clinical Diagnosis of Diabetic Nephropathy with Femto-Molar Sensitivity By Immunopillar Devices Reviewed

    Miaomiao Sun, Toshihiro Kasama, Yukio Yuzawa, Shin-Ichi Akiyama, Seiichi Matsuo, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 812-814   2012.10

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  465. Plasma Separation from Human Blood Using Spiral Microchannels for Dry Eye Treatment Reviewed

    Jumpei Morikawa, Takao Yasui, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, Kazuo Tsubota, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 464-466   2012.10

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  466. Nanopillar Parallel-Array Structure with DNA Trapping and Torque-Assisted Escape Mode For DNA Separation Reviewed

    Takao Yasui, Koki Motoyama, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, Yasuhiro Horiike, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 1186-1188   2012.10

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  467. Label-Free Detection of Real-Time DNA Amplification Using Nanowall Array Structures Reviewed

    Kensuke Ogawa, Takao Yasui, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, Yasuhiro Horiike, Mats Nilsson, Yoshinobu Baba

    Micro Total Analysis Systems 2012     page: 25-27   2012.10

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  468. Exploring the dramatic dependence of ssDNA: histone assembly on oligomer length

    Serag Maged F., Kaji Noritada, Dwyer Jason R., Baba Yoshinobu

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 244   page: .   2012.8

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  469. 量子ドットのバイオ応用最前線

    湯川博, 小野島大介, 馬場嘉信

    現代化学   Vol. 498 ( 9 ) page: 31-35   2012.8

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  470. Direct Cytotoxicity of Lentinula edodes Mycelia Extract on Human Hepatocellular Carcinoma Cell Line Reviewed

    H. Yukawa, S. Ishikawa, T. Kawanishi, M. Tamesada, and H. Tomi

    Biological & Pharmaceutical Bulletin   Vol. 35 ( 7 ) page: 1014-1021   2012.7

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  471. Toward the integrated optimization of steel plate production process - A proposal for production control by multi-scale hierarchical modeling

    Nishioka K.

    Synthesiology   Vol. 5 ( 2 ) page: 98-112   2012.6

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  472. Fabrication of Functionalized Double-Lamellar Multifunctional Envelope-Type Nanodevices Using a Microfluidic Chip with a Chaotic Mixer Array Reviewed

    K. Kitazoe, Y.S. Park, N. Kaji, Y. Okamoto, M. Tokeshi, K. Kogure, H. Harashima, and Y. Baba

    PLoS One   Vol. 7 ( 6 ) page: 8   2012.6

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  473. ナノバイオデバイスが拓く再生医療研究の新展開

    馬場嘉信

    再生医療   Vol. 11 ( 2 ) page: 127-139   2012.5

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  474. Nanobiodevices for Future Personalized Medicine

    BABA Yoshinobu

    The Journal of the Institute of Electronics, Information, and Communication Engineers   Vol. 95 ( 4 ) page: 310-314   2012.4

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  475. パイこね変換に基づく量産対応・高速ミキサの開発 Reviewed

    尾本悠輔, 加藤大香士, 鈴木教和, 安井隆雄, 大里恵子, 加地範匡, 渡慶次学, 馬場嘉信, 酒井康彦, and 社本英二

    日本機械学会論文集   Vol. 78 ( 788 ) page: 762-768   2012.4

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  476. ナノバイオデバイスによる未来医療

    馬場嘉信

    電子情報通信学会誌   Vol. 95 ( 4 ) page: 310-314   2012.4

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  477. Nanobiodevice based single molecule and single cell sensing for cancer diagnosis and in vivo imaging of stem cell therapy

    Baba Yoshinobu

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 243   page: .   2012.3

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  478. Accurate detection of carcinoma cells by use of a cell microarray chip Reviewed

    Y. Shohei, Y. Shouki, Y. Yuka, S. Yasuo, T. Eiichi, H. Toshihiro, B. Yoshinobu, and K. Masatoshi

    PLoS One   Vol. 7 ( 3 ) page: e32370   2012.3

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  479. Monitoring transplanted adipose tissue-derived stem cells combined with heparin in the liver by fluorescence imaging using quantum dots Reviewed

    H. Yukawa, M. Watanabe, N. Kaji, Y. Okamoto, M. Tokeshi, Y. Miyamoto, H. Noguchi, Y. Baba, and S. Hayashi

    Biomaterials   Vol. 33 ( 7 ) page: 2177-2186   2012.3

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  480. Monitoring transplanted adipose tissue-derived stem cells combined with heparin in the liver by fluorescence imaging using quantum dots

    Yukawa Hiroshi, Watanabe Masaki, Kaji Noritada, Okamoto Yukihiro, Tokeshi Manabu, Miyamoto Yoshitaka, Noguchi Hirofumi, Baba Yoshinobu, Hayashi Shuji

    BIOMATERIALS   Vol. 33 ( 7 ) page: 2177 - 86   2012.3

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    DOI: 10.1016/j.biomaterials.2011.12.009

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  481. Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice Cancer Cell International

    Y. Hanai, K. Shimono, H. Oka, Y. Baba, K. Yamazaki, and G.K. Beauchamp

    Cancer Cell International   Vol. 12 ( 1 ) page: 7   2012.2

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    DOI: 10.1186/1475-2867-12-7

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  482. Introducing carbon nanotubes into living walled plant cells through cellulase-induced nanoholes Reviewed

    Maged F. Serag, Noritada Kaji, Manabu Tokeshi, and Yoshinobu Baba

    RSC Advances   Vol. 2 ( 2 ) page: 398-400   2012.2

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  483. The plant cell uses carbon nanotubes to build tracheary elements Reviewed

    M.F. Serag, N. Kaji, M. Tokeshi, A. Bianco, and Y. Baba

    Integrative Biology   Vol. 4 ( 2 ) page: 127-131   2012.2

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  484. Cryopreservation of Human Adipose Tissue-Derived Stem/Progenitor Cells Using the Silk Protein Sericin Reviewed

    Y. Miyamoto, K. Oishi, H. Yukawa, H. Noguchi, M. Sasaki, H. Iwata, and S. Hayashi

    Cell Transplant   Vol. 21 ( 2-3 ) page: 617-622   2012.2

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  485. Single and hypofractionated stereotactic radiotherapy with CyberKnife for craniopharyngioma

    Iwata H.

    Journal of Neuro-Oncology   Vol. 106 ( 3 ) page: 571-577   2012.2

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    DOI: 10.1007/s11060-011-0693-3

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  486. The plant cell uses carbon nanotubes to build tracheary elements

    Serag Maged F., Kaji Noritada, Tokeshi Manabu, Bianco Alberto, Baba Yoshinobu

    INTEGRATIVE BIOLOGY   Vol. 4 ( 2 ) page: 127 - 31   2012.2

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    DOI: 10.1039/c2ib00135g

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  487. Confocal Microscopic Evaluation of Mixing Performance for Three-Dimensional Microfluidic Mixer

    YASUI Takao, OMOTO Yusuke, OSATO Keiko, KAJI Noritada, SUZUKI Norikazu, NAITO Toyohiro, OKAMOTO Yukihiro, TOKESHI Manabu, SHAMOTO Eiji, BABA Yoshinobu

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 28 ( 1 ) page: 57-59   2012.1

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  488. Aqueous Phase Synthesized CdSe Magic-Sized Clusters: Solution Composition Dependence of Adsorption Layer Structure Reviewed

    Yeon-Su Park, Yukihiro Okamoto, Noritada Kaji, Manabu Tokeshi, and Yoshinobu Baba

    J. Nanoparticle Res.   Vol. 12 ( 1 ) page: 539-546   2012.1

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  489. How environmental solution condistion decide the compaction velocity of single DNA moleules Reviewed

    Ken Hirano, Masatoshi Ichikawa, Tomomi Ishido, Mitsuru Ishikawa, Yoshinobu Baba and Kenichi Yoshikawa

    Nucleic Acids Res.   Vol. 40 ( 1 ) page: 284-289   2012.1

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  490. Confocal Microscopic Evaluation of Mixing Performance for Three-Dimensional Microfluidic Mixer Reviewed

    T. Yasui, Y. Omoto, K. Osato, N. Kaji, N. Suzuki, T. Naito, Y. Okamoto, M. Tokeshi, E. Shamoto, and Y. Baba

    Analytical Science   Vol. 28 ( 1 ) page: 57-59   2012.1

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  491. Differentiation of Mouse Pancreatic Stem Cells Into Insulin-Producing Cells by Recombinant Sendai Virus-Mediated Gene Transfer Technology Reviewed

    Hiroshi Yukawa, Hirofumi Noguchi, Koichi Oishi, Yoshitaka Miyamoto, Makoto Inoue, Mamoru Hasegawa, Shuji Hayashi, and Yoshinobu Baba

    Cell Medicine   Vol. 3   page: 51-61   2012.1

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    DOI: http://dx.doi.org/10.3727/215517912X639487

  492. Aqueous Phase Synthesized CdSe Magic-Sized Clusters: Solution Composition Dependence of Adsorption Layer Structure International journal

    Park Yeon-Su, Okamoto Yukihiro, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY   Vol. 12 ( 1 ) page: 539 - 46   2012.1

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    DOI: 10.1166/jnn.2012.5354

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  493. Confocal Microscopic Evaluation of Mixing Performance for Three-Dimensional Microfluidic Mixer

    Yasui Takao, Omoto Yusuke, Osato Keiko, Kaji Noritada, Suzuki Norikazu, Naito Toyohiro, Okamoto Yukihiro, Tokeshi Manabu, Shamoto Eiji, Baba Yoshinobu

    ANALYTICAL SCIENCES   Vol. 28 ( 1 ) page: 57-59   2012.1

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  494. Differentiation of Mouse Pancreatic Stem Cells Into Insulin-Producing Cells by Recombinant Sendai Virus-Mediated Gene Transfer Technology.

    Yukawa H, Noguchi H, Oishi K, Miyamoto Y, Inoue M, Hasegawa M, Hayashi S, Baba Y

    Cell medicine   Vol. 3 ( 1-3 ) page: 51-61   2012.1

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    DOI: 10.3727/215517912X639487

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  495. How environmental solution conditions determine the compaction velocity of single DNA molecules

    Hirano Ken, Ichikawa Masatoshi, Ishido Tomomi, Ishikawa Mitsuru, Baba Yoshinobu, Yoshikawa Kenichi

    NUCLEIC ACIDS RESEARCH   Vol. 40 ( 1 ) page: 284 - 9   2012.1

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    DOI: 10.1093/nar/gkr712

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  496. A deep microfluidic absorbance detection cell replicated from a thickly stacked SU-8 dry film resist mold

    Onoshima Daisuke, Wang Jun, Aki Michihiko, Arinaga Kenji, Kaji Noritada, Tokeshi Manabu, Fujita Shozo, Yokoyama Naoki, Baba Yoshinobu

    ANALYTICAL METHODS   Vol. 4 ( 12 ) page: 4368-4372   2012

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    DOI: 10.1039/c2ay26099a

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  497. Accurate Detection of Carcinoma Cells by Use of a Cell Microarray Chip

    Yamamura Shohei, Yatsushiro Shouki, Yamaguchi Yuka, Abe Kaori, Shinohara Yasuo, Tamiya Eiichi, Baba Yoshinobu, Kataoka Masatoshi

    PLOS ONE   Vol. 7 ( 3 ) page: e32370   2012

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    DOI: 10.1371/journal.pone.0032370

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  498. Confocal microscopic evaluation of mixing performance for three-dimensional microfluidic mixer.

    Yasui T, Omoto Y, Osato K, Kaji N, Suzuki N, Naito T, Okamoto Y, Tokeshi M, Shamoto E, Baba Y

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 28 ( 1 ) page: 57 - 9   2012

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    DOI: 10.2116/analsci.28.57

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  499. Fabrication of Functionalized Double-Lamellar Multifunctional Envelope-Type Nanodevices Using a Microfluidic Chip with a Chaotic Mixer Array

    Kitazoe Katsuma, Park Yeon-Su, Kaji Noritada, Okamoto Yukihiro, Tokeshi Manabu, Kogure Kentaro, Harashima Hideyoshi, Baba Yoshinobu

    PLOS ONE   Vol. 7 ( 6 ) page: e39057   2012

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    DOI: 10.1371/journal.pone.0039057

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  500. Introducing carbon nanotubes into living walled plant cells through cellulase-induced nanoholes

    Serag Maged F., Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    RSC ADVANCES   Vol. 2 ( 2 ) page: 398 - 400   2012

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    DOI: 10.1039/c1ra00760b

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  501. Polysaccharide Functionalized Magnetic Nanoparticles for Cell Labeling and Tracking: A New Three-Dimensional Cell-Array System for Toxicity Testing

    Miyamoto Y., Koshidaka Y., Noguchi H., Oishi K., Saito H., Yukawa H., Kaji N., Ikeya T., Iwata H., Baba Y., Murase K., Hayashi S.

    NANOMATERIALS FOR BIOMEDICINE   Vol. 1119   page: 191-+   2012

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  502. Size-selective synthesis of ultrasmall hydrophilic CdSe nanoparticles in aqueous solution at room temperature.

    Park YS, Okamoto Y, Kaji N, Tokeshi M, Baba Y

    Methods in molecular biology (Clifton, N.J.)   Vol. 906   page: 125 - 41   2012

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    DOI: 10.1007/978-1-61779-953-2_9

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  503. Development of Mass-Producible Rapid Mixer Based on Baker's Transformation

    SHAMOTO Eiji, KATO Takashi, SUZUKI Norikazu

    TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B   Vol. 78 ( 788 ) page: 762-768   2012

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    We developed a new passive-type lamination mixer for high viscosity fluid with a low Reynolds number, based on the baker's transformation (BT). BT is the best transformation for mixing fluids of laminar flow. However, there was difficulty in mass-producing the BT structure especially for micro devices like MicroTAS, Lab-on-a-Chip and Micro-Reactors, because conventional BT mixers require three-dimensional (3D) piping structures. We have successfully developed the easy-to-massproduce BT mixer by changing that concept of 3D piping structures to 3D channel structures. The 3D channel structures are not easy to produce by photolithography unlike the conventional mixers, while they can be easily mass-produced by molding once their 3D molds are produced. In this report, we newly developed a miniature scale BT mixer to meet the needs for mixing high viscosity fluids in food processing, resin blending, etc. An experiment for mixing different colored hardening silicone elastomers was performed by using the prototype mixer made of aluminum alloy, and the good BT mixing result was obtained, with observing several cross sectional patterns. The numerical fluid analysis also gave similar results of the patterns to those observed in the experiment.

    DOI: 10.1299/kikaib.78.762

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  504. Characterization of low viscosity polymer solutions for microchip electrophoresis of non-denatured proteins on plastic chips, Biomicrofluidics Reviewed

    T. Yasui, M.R. Mohamadi, N. Kaji, Y. Okamoto, M. Tokeshi, and Y. Baba

    Biomicrofluidics   Vol. 5 ( 4 ) page: 044114-1-9   2011.12

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  505. Characterization of low viscosity polymer solutions for microchip electrophoresis of non-denatured proteins on plastic chips

    Yasui Takao, Mohamadi Mohamad Reza, Kaji Noritada, Okamoto Yukihiro, Tokeshi Manabu, Baba Yoshinobu

    BIOMICROFLUIDICS   Vol. 5 ( 4 ) page: 44114 - 441149   2011.12

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    DOI: 10.1063/1.3668233

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  506. Functional Platform for Controlled Subcellular Distribution of Carbon Nanotubes

    Serag, M. F. Kaji, N. Venturelli, E. Okamoto, Y. Terasaka, K. Tokeshi, M. Mizukami, H. Braeckmans, K. Bianco, A. Baba, Y.

    Acs Nano   Vol. 5 ( 11 ) page: 9264 - 70   2011.11

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    DOI: 10.1021/nn2035654

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  507. Estimation of the Distribution of Intravenously Injected Adipose Tissue-Derived Stem Cells Labeled with Quantum Dots in Mice Organs through the Determination of their Metallic Components by ICPMS

    Takasaki Yuka, Watanabe Masaki, Yukawa Hiroshi, Sabarudin Akhmad, Inagaki Kazumi, Kaji Noritada, Okamoto Yukihiro, Tokeshi Manabu, Miyamoto Yoshitaka, Noguchi Hirofumi, Umemura Tomonari, Hayashi Shuji, Baba Yoshinobu, Haraguchi Hiroki

    ANALYTICAL CHEMISTRY   Vol. 83 ( 21 ) page: 8252 - 8   2011.11

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    DOI: 10.1021/ac202053y

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  508. Rapid Qualitative Evaluation of DNA Transcription Factor Nf-kb By Microchip Electrophoretic Mobility Shift Assay In Mammalian Cells Reviewed

    S. Inoue, N. Kaji, M. Kataoka, Y. Shinohara, Y. Okamoto, M. Tokeshi, and Y. Baba

    Electrophoresis   Vol. 32 ( 22 ) page: 3241-3247   2011.11

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  509. Estimation of the Distribution of Intravenously Injected Adipose Tissue-Derived Stem Cells Labeled with Quantum Dots in Mice Organs through the Determination of their Metallic Components by ICPMS Reviewed

    Y. Takasaki, M. Watanabe, H. Yukawa, A. Sabarudin, K. Inagaki, N. Kaji, Y. Okamoto, M. Tokeshi, Y. Miyamoto, H. Noguchi, T. Umemura, S. Hayashi, Y. Baba, and H. Haraguchi

    Anal. Chem   Vol. 83 ( 21 ) page: 8252-8   2011.11

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  510. Transcriptional microarray analysis reveals suppression of histamine signaling by Kujin alleviates allergic symptoms through down-regulation of FAT10 expression Reviewed

    Dev Shrabanti, Hiroyuki Mizuguchi, Das Asish Kumar, Yoshinobu Baba, Hiroyuki Fukui

    Int. Immunology   Vol. 11   page: 1504-1509   2011.11

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  511. Rapid qualitative evaluation of DNA transcription factor NF-kappa B by microchip electrophoretic mobility shift assay in mammalian cells

    Inoue Sonoko, Kaji Noritada, Kataoka Masatoshi, Shinohara Yasuo, Okamoto Yukihiro, Tokeshi Manabu, Baba Yoshinobu

    ELECTROPHORESIS   Vol. 32 ( 22 ) page: 3241 - 7   2011.11

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    DOI: 10.1002/elps.201100261

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  512. Electroosmotic Flow in Nanopillar Chips Reviewed

    Takao Yasui, Noritada Kaji, M. Reza Mohamadi, Yukihiro Okamoto, Manabu Tokeshi, Yasuhiro Horiike and Yoshinobu Baba

    ACS Nano   Vol. 5 ( 10 ) page: 7775-80   2011.10

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  513. Electroosmotic Flow in Microchannels with Nanostructures

    Yasui Takao, Kaji Noritada, Mohamadi Mohamad Reza, Okamoto Yukihiro, Tokeshi Manabu, Horiike Yasuhiro, Baba Yoshinobu

    ACS NANO   Vol. 5 ( 10 ) page: 7775 - 80   2011.10

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    DOI: 10.1021/nn2030379

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  514. A touch-and-go lipid wrapping technique in microfluidic channels for rapid fabrication of multifunctional envelope-type gene delivery nanodevices

    Kitazoe Katsuma, Wang Jun, Kaji Noritada, Okamoto Yukihiro, Tokeshi Manabu, Kogure Kentaro, Harashima Hideyoshi, Baba Yoshinobu

    LAB ON A CHIP   Vol. 11 ( 19 ) page: 3256 - 62   2011.10

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    DOI: 10.1039/c1lc20392d

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  515. Microfluidic baker's transformation device for three-dimensional rapid mixing International journal

    Yasui Takao, Omoto Yusuke, Osato Keiko, Kaji Noritada, Suzuki Norikazu, Naito Toyohiro, Watanabe Masaki, Okamoto Yukihiro, Tokeshi Manabu, Shamoto Eiji, Baba Yoshinobu

    LAB ON A CHIP   Vol. 11 ( 19 ) page: 3356 - 60   2011.10

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    DOI: 10.1039/c1lc20342h

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  516. A clinical trial for therapeutic drug monitoring using microchip-based fluorescence polarization immunoassay Reviewed

    T. Tachi, T. Hase, Y. Okamoto, N. Kaji, T. Arima, H. Matsumoto, M. Kondo, M. Tokeshi, Y. Hasegawa, and Y. Baba

    Analytical and bioanalytical chemistry   Vol. 401 ( 7 ) page: 2301-2305   2011.10

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  517. Microfluidic baker's transformation device for three-dimensional rapid mixing Reviewed

    T. Yasui, Y. Omoto, K. Osato, N. Kaji, N. Suzuki, T. Naito, M. Watanabe, Y. Okamoto, M. Tokeshi, E. Shamoto, and Y. Baba

    Lab on a Chip   Vol. 11 ( 19 ) page: 3356-3360   2011.10

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  518. A touch-and-go lipid wrapping technique in microfluidic channels for rapid fabrication of multifunctional envelope-type gene delivery nanodevices Reviewed

    K. Kitazoe, J. Wang, N. Kaji, Y. Okamoto, M. Tokeshi, K. Kogure, H. Harashima, and Y. Baba

    Lab on a Chip   Vol. 11 ( 19 ) page: 3256-3262   2011.10

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  519. SINGLE MOLECULE ENZYMATIC KINETICS IN SUBCELLULAR-SIZED NANOSPACES USING PNEUMATIC VALVE-ASSISTED ATTO-LITER CHAMBER ARRAY DEVICES Reviewed

    Kasuki Iiijima, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, and Yoshinobu Baba

    Micro Total Analysis Systems 2011     page: 1092-1094.   2011.10

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  520. DNA TRAPPING AT THE INTERFACE OF NANOPILLAR AND NANOPILLAR-FREE REGIONS FOR LONG DNA SEPARATION Reviewed

    Koki Motoyama, Takao Yasui, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi and Yoshinobu Baba

    Micro Total Analysis Systems 2011     page: 647-649   2011.10

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  521. EPIGENETIC ANALYSIS OF A SINGLE DNA MOLECULE BY MICROFLUIDIC DEVICE WITH QUANTUM DOT Reviewed

    .Tatsuki Sano, Yukihiro Okamoto, Noritada Kaji, Manabu Tokeshi, and Yoshinobu Baba

    Micro Total Analysis Systems 2011     page: 1909-1911   2011.10

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  522. MICROFLUIDIC CELL SEPARATION WITH ANTIBODY MODIFIED EUGLENA BY USING PHOTOTAXIS MEDIATED MIGRATION Reviewed

    Yukihiro Okamoto, Yukinori Nakakita, Takahiro Sano, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

    Micro Total Analysis Systems 2011     page: 1909-1911   2011.10

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  523. LONG-TERM STRESSLESS CELL CULTURE CHIPS FOR NON-ADHESIVE CELLS Reviewed

    Toyohiro Naito ,Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, and Yoshinobu Baba

    Micro Total Analysis Systems 2011     page: 1909-1911   2011.10

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  524. TEMPERATURE-DRIVEN SELF-ACTUATED MICROVALVE FOR PCR Reviewed

    Toyohiro Naito, Rerngchai Arayanarakool, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, Serine Le Gac, Albert van den Berg and Yoshinobu Baba

    Micro Total Analysis Systems 2011     page: 248-250   2011.10

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  525. NANOWALL ARRAY CHIPS FOR DNA SEPARATION Reviewed

    Takao Yasui, Naoritada Kaji, Ryo Ogawa, Shingi Hashioka, Manabu Tokeshi, Yasuhiro Horiike, and Yoshinobu Baba

    Micro Total Analysis Systems 2011     page: 638-640   2011.10

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  526. Maged F. Serag, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi and Yoshinobu Baba Reviewed

    A DNA SIZE PROBE BASED ON ENERGY MIGRATION IN CROSS-LINKED CHROMATIN

    Micro Total Analysis Systems     page: 58-60   2011.10

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  527. LABEL-FREE DETECTION OF DNA USING DIFFRACTED LASER IN NANOWALL ARRAY STRUCTURES Reviewed

    Micro Total Analysis Systems 2011     page: 54-56   2011.10

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  528. MICROFLUIDIC VISUALIZATION OF ENCOUNTER COMPLEX IN ENZYMATIC DIGESTION OF SINGLE DNA MOLECULE BY DUAL MOLECULAR TAGGING Reviewed

    Micro Total Analysis Systems 2011     page: 2061-2063   2011.10

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  529. A clinical trial for therapeutic drug monitoring using microchip-based fluorescence polarization immunoassay International journal

    Tachi Tomoya, Hase Tetsunari, Okamoto Yukihiro, Kaji Noritada, Arima Takeshi, Matsumoto Hiroyuki, Kondo Masashi, Tokeshi Manabu, Hasegawa Yoshinori, Baba Yoshinobu

    ANALYTICAL AND BIOANALYTICAL CHEMISTRY   Vol. 401 ( 7 ) page: 2301 - 5   2011.10

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    DOI: 10.1007/s00216-011-5304-9

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  530. A DNA MICROARRAY-BASED ANALYSIS OF THE HOST RESPONSE TO A NONVIRAL GENE CARRIER: EXPLORING CPG-DEPENDENT/INDEPENDENT MECHANISMS

    Hatakeyama H., Yamamoto M., Hayashi Y., Kajimoto K., Akita H., Kaji N., Baba Y., Harashima H.

    NUCLEIC ACID THERAPEUTICS   Vol. 21 ( 5 ) page: A34-A34   2011.10

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  531. Transcriptional microarray analysis reveals suppression of histamine signaling by Kujin alleviates allergic symptoms through down-regulation of FAT10 expression International journal

    Dev Shrabanti, Mizuguchi Hiroyuki, Das Asish Kumar, Baba Yoshinobu, Fukui Hiroyuki

    INTERNATIONAL IMMUNOPHARMACOLOGY   Vol. 11 ( 10 ) page: 1504 - 9   2011.10

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    DOI: 10.1016/j.intimp.2011.05.004

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  532. DNA Separation in Nanowall Array Chips

    Yasui Takao, Kaji Noritada, Ogawa Ryo, Hashioka Shingi, Tokeshi Manabu, Horiike Yasuhiro, Baba Yoshinobu

    ANALYTICAL CHEMISTRY   Vol. 83 ( 17 ) page: 6635 - 40   2011.9

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    DOI: 10.1021/ac201184t

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  533. DNA Separation in Nanowall Array Chips Reviewed

    T. Yasui, N. Kaji, R. Ogawa, S. Hashioka, M. Tokeshi, Y. Horiike, and Y. Baba

    Analytical Chemistry   Vol. 83 ( 17 ) page: 6635-6640   2011.9

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  534. Nanobiodevices for Genome Analysis, Proteome Analysis, and Biomedical Applications

    Baba Yoshinobu

    Bulletin of the Chemical Society of Japan   Vol. 84 ( 8 ) page: 819-828   2011.8

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  535. Nanobiodevices for Genome Analysis, Proteome Analysis, and Biomedical Applications International journal

    Baba Yoshinobu

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   Vol. 84 ( 8 ) page: 819 - 828   2011.8

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    DOI: 10.1246/bcsj.20100341

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  536. Hypofractionated stereotactic radiotherapy with CyberKnife for nonfunctioning pituitary adenoma: High local control with low toxicity

    Iwata H.

    Neuro-Oncology   Vol. 13 ( 8 ) page: 916-922   2011.8

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    DOI: 10.1093/neuonc/nor055

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  537. Nanobiodevice for genome analysis, proteome analysis, and biomedical applications

    Y. Baba

    Bull. Chem. Soc. Jpn., The Award Accounts   Vol. 84 ( 8 ) page: 819-828   2011.7

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  538. ナノ構造体を用いた無標識検出 Reviewed

    安井、加地、岡本、渡慶次、堀池、馬場

      Vol. 8   page: 43-45   2011.6

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  539. Label-free detection using nanostructures

    YASUI Takao, KAJI Noritada, OKAMOTO Yukihiro, TOKESHI Manabu, HORIIKE Yasuhiro, BABA Yoshinobu

      Vol. 2011 ( 8 ) page: 43-45   2011.6

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  540. Ribonuclease protection assay on microchip electrophoresis Reviewed

    Yuka Yamaguchi, Shouki Yatsushiro, Shohei Yamamura, Hiroko Abe, Kaori Abe, Masahiro Watanabe, Kazuaki Kajimoto, Yasuo Shinohara, Yoshinobu Baba and Masatoshi Kataoka

    Analyst   Vol. 136 ( 11 ) page: 2247-2251   2011.6

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    DOI: 10.1039/C0AN01044H

  541. Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid. Reviewed

    Hatakeyama H, Akita H, Ito E, Hayashi Y, Oishi M, Nagasaki Y, Danev R, Nagayama K, Kaji N, Kikuchi H, Baba Y, Harashima H.

    Biomaterials   Vol. 32 ( 18 ) page: 4306-4316   2011.6

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  542. Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid

    Hatakeyama Hiroto, Akita Hidetaka, Ito Erika, Hayashi Yasuhiro, Oishi Motoi, Nagasaki Yukio, Danev Radostin, Nagayama Kuniaki, Kaji Noritada, Kikuchi Hiroshi, Baba Yoshinobu, Harashima Hideyoshi

    BIOMATERIALS   Vol. 32 ( 18 ) page: 4306 - 16   2011.6

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    DOI: 10.1016/j.biomaterials.2011.02.045

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  543. Label-Free Detection of DNA-Binding Proteins Based on Microfluidic Solid-State Molecular Beacon Sensor Reviewed

    Jun Wang, Daisuke Onoshima, Michihiko Aki, Yukihiro Okamoto, Noritada Kaji, Manabu Tokeshi, and Yoshinobu Baba

    Anal. Chem.   Vol. 83 ( 9 ) page: 3528-3532   2011.5

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    DOI: 10.1021/ac200236r

  544. Label-Free Detection of DNA-Binding Proteins Based on Microfluidic Solid-State Molecular Beacon Sensor

    Wang Jun, Onoshima Daisuke, Aki Michihiko, Okamoto Yukihiro, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    ANALYTICAL CHEMISTRY   Vol. 83 ( 9 ) page: 3528-3532   2011.5

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    DOI: 10.1021/ac200236r

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  545. Highly sensitive DNA detection with a combination of 2 DNA-intercalating dyes for microchip electrophoresis Reviewed

    Shouki Yatsushiro, Yuka Yamaguchi, Shohei Yamamura, Yasuo Shinohara, Yoshinobu Baba, Masatoshi Kataoka

    J. Pharm. Biomed. Anal.   Vol. 55 ( 1 ) page: 202-205   2011.4

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    DOI: 10.1016/j.jpba.2010.12.014

  546. Highly sensitive DNA detection with a combination of 2 DNA-intercalating dyes for microchip electrophoresis

    Yatsushiro Shouki, Yamaguchi Yuka, Yamamura Shohei, Shinohara Yasuo, Baba Yoshinobu, Kataoka Masatoshi

    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS   Vol. 55 ( 1 ) page: 202-205   2011.4

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    DOI: 10.1016/j.jpba.2010.12.014

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  547. Quantitative Analysis of Serum Procollagen Type I C-Terminal Propeptide by Immunoassay on Microchip Reviewed

    Shouki Yatsushiro, Rie Akamine, Shohei Yamamura, Mami Hino, Kazuaki Kajimoto, Kaori Abe,Hiroko Abe, Jun-ichi Kido, Masato Tanaka, Yasuo Shinohara, Yoshinobu Baba, Toshihiko Ooie, Masatoshi Kataoka

    PLOS One   Vol. 6 ( 4 ) page: e18807   2011.4

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  548. Quantitative Analysis of Serum Procollagen Type I C-Terminal Propeptide by Immunoassay on Microchip

    Yatsushiro Shouki, Akamine Rie, Yamamura Shohei, Hino Mami, Kajimoto Kazuaki, Abe Kaori, Abe Hiroko, Kido Jun-ichi, Tanaka Masato, Shinohara Yasuo, Baba Yoshinobu, Ooie Toshihiko, Kataoka Masatoshi

    PLOS ONE   Vol. 6 ( 4 ) page: e18807   2011.4

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    DOI: 10.1371/journal.pone.0018807

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  549. Online transient isotachophoresis concentration by the pesudo-terminating electrolyte for the separation of DNA-aptamer and its thrombin complex in poly(methyl methacrylate) microchip electrophoresis Reviewed

    Jun Wang, Yong Zhang, Yukihiro Okamoto, Noritada Kaji, Manabu Tokeshi and Yoshinobu Baba

      Vol. 136 ( 6 ) page: 1142-1147   2011.3

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    DOI: 10.1039/c0an00434k

  550. Tracking Degradations of Single DNA and Protein Molecules in Fluid Reviewed

    D. Onoshima, N. Kaji, M. Tokeshi, and Y. Baba

    Biophysical Society 55th Annual Meeting   Vol. 100 ( 3 ) page: 151a-152a   2011.3

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  551. A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Reviewed

    Hiroto Hatakeyama, Erika Ito, Momoko Yamamoto, Hidetaka Akita, Yasuhiro Hayashi, Kazuaki Kajimoto, Noritada Kaji, Yoshinobu Baba and Hideyoshi Harashima

    Molecular Therapy     2011.3

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    DOI: 10.1038/mt.2011.24

  552. Laser-controlled Injector for Biological Applications Reviewed International journal

    Ooie Toshihiko, Tanaka Masato, Nakahara Tomonori, Yamachoshi Yuji, Akamine Rie, Kataoka Masatoshi, Baba Yoshinobu

    JOURNAL OF LASER MICRO NANOENGINEERING   Vol. 6 ( 1 ) page: 44 - 48   2011.3

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    DOI: 10.2961/jlmn.2011.01.0010

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  553. 量子ドットによる幹細胞のin vivoイメージング

    渡辺将生、湯川博、鏡味幸真、加地範匡、宮本義孝、岡本行広、渡慶次学、林衆治、馬場嘉信

    生命化学研究レター   Vol. 35   page: 38-42   2011.2

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  554. Aqueous Phase-Synthesized Small CdSe Quantum Dots: Adsorption Layer Structure and Strong Band-Edge and Surface Trap Emission Reviewed

    Yeon-Su Park, Yukihiro Okamoto, Noritada Kaji, Manabu Tokeshi, and Yoshinobu Baba

    J. Nanoparticle Res.     2011.2

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    DOI: 10.1007/s11051-011-0273-7

  555. ナノバイオデバイスによる健康予知診断

    馬場嘉信

    臨床化学   Vol. 40 ( 1 ) page: 36-44   2011.1

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  556. Nanobiodevice based disease diagnosis and healthcare

    Baba Y.

    Japanese Journal of Clinical Chemistry   Vol. 40 ( 1 ) page: 444-452   2011.1

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  557. Trafficking and Subcellular Localization of Multiwalled Carbon Nanotubes in Plant Cells Reviewed

    Maged F. Serag, Noritada Kaji, Claire Gaillard, Yukihiro Okamoto, Kazuyoshi Terasaka, Mohammad Jabasini, Manabu Tokeshi, Hajime Mizukami, Alberto Bianco, and Yoshinobu Baba

      Vol. 5 ( 1 ) page: 493-499   2011.1

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    DOI: 10.1021/nn102344t

  558. Trafficking and Subcellular Localization of Multiwalled Carbon Nanotubes in Plant Cells

    Serag Maged F., Kaji Noritada, Gaillard Claire, Okamoto Yukihiro, Terasaka Kazuyoshi, Jabasini Mohammad, Tokeshi Manabu, Mizukami Hajime, Bianco Alberto, Baba Yoshinobu

    ACS NANO   Vol. 5 ( 1 ) page: 493-499   2011.1

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    DOI: 10.1021/nn102344t

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  559. ナノバイオデバイスが拓く未来医療

    馬場嘉信

    サイテック     page: 1-19   2011

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  560. Online transient isotachophoresis concentration by the pseudo-terminating electrolyte buffer for the separation of DNA-aptamer and its thrombin complex in poly(methyl methacrylate) microchip

    Wang Jun, Zhang Yong, Okamoto Yukihiro, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu

    ANALYST   Vol. 136 ( 6 ) page: 1142-1147   2011

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    DOI: 10.1039/c0an00434k

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  561. Ribonuclease protection assay on microchip electrophoresis

    Yamaguchi Yuka, Yatsushiro Shouki, Yamamura Shohei, Abe Hiroko, Abe Kaori, Watanabe Masahiro, Kajimoto Kazuaki, Shinohara Yasuo, Baba Yoshinobu, Kataoka Masatoshi

    ANALYST   Vol. 136 ( 11 ) page: 2247-2251   2011

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    DOI: 10.1039/c0an01044h

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  562. ナノ構造を利用した電気泳動によるOmics解析

    馬場 嘉信

    日本臨床プロテオーム研究会要旨集   Vol. 2011 ( 0 )   2011

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    DOI: 10.14905/jscp.2011.0_13

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  563. Immuno-Pillar Chip: A New Platform For Rapid And Easy-To-Use Immunoassay

    Mai Ikami, A. Kawakami, M. Kakuta Manabu Tokeshi, Noritada Kaji And Yoshinobu Baba

    Lab on a Chip   Vol. 10 ( 24 ) page: 3335 - 40   2010.12

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    DOI: 10.1039/c0lc00241k

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  564. Editorial: 10th Anniversary Issue: Japan

    Y. Baba

    Lab on a Chip   Vol. 10   page: 3324   2010.12

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    DOI: 10.1039/C0LC90086A

  565. Aqueous Phase-Synthesized CdSe Nanoparticles with Well-Defined Numbers of Constituent Atoms

    Yeon-Su Park, Andriy Dmytruk, Igor Dmitruk, Atsuo Kasuya, Yukihiro Okamoto, Noritada Kaji, Manabu Tokeshi and Yoshinobu Baba

    J. Phys. Chem.C   Vol. 114 ( 44 ) page: 18834 - 18840   2010.11

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    DOI: 10.1021/jp107608b

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  566. Consecutive Incorporation of Fluorophore-Labelled Nucleotides by Mammalian DNA Polymerase beta

    Ken Hirano, Yuichiro Yoshida, Tomomi Ishido, Naoshi Yamazaki, Yoshiyuki Mizushina,Yoshinobu Baba and Mitsuru Ishikawa

    Anal. Biochem.   Vol. 405 ( 2 ) page: 160 - 7   2010.10

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    DOI: 10.1016/j.ab.2010.06.005

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  567. Rapid and Highly Sensitive Detection of Malaria-Infected Erythrocytes Using a Cell Microarray Chip

    Yatsushiro Shouki, Yamamura Shohei, Yamaguchi Yuka, Shinohara Yasuo, Tamiya Eiichi, Horii Toshihiro, Baba Yoshinobu, Kataoka Masatoshi

    PLOS ONE   Vol. 5 ( 10 ) page: e13179   2010.10

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    DOI: 10.1371/journal.pone.0013179

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  568. Development of an Easy and High-Throughput Cell Assay System with a Culture Chip and an Assay Chip

    SUGIURA Kanako, KAJI Noritada, OKAMOTO Yukihiro, TOKESHI Manabu, BABA Yoshinobu

      Vol. 130 ( 10 ) page: 471-475   2010.10

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  569. Rapid and Highly Sensitive Detection of Malaria-Infected Erythrocytes Using a Cell Microarray Chip Reviewed

    S. Yatsushiro, S. Yamamura, Y. Yamaguchi, Y. Shinohara, E. Tamiya, T. Horii, Y. Baba, and M. Kataoka

    PLoS One   Vol. 5 ( 10 ) page: e13179-1~8   2010.10

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    DOI: 10.1371/journal.pone.0013179

  570. DEVELOPMENT OF THREE-STEP CONSOLIDATING MICROCHIP FOR THERAPEUTIC DRUG MONITORING Reviewed

    Kanako Sugiura, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi and Yoshinobu Baba

    Micro Total Analysis System 2010     page: 806-808   2010.10

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  571. TRACKING OF SINGLE DNA AND PROTEIN MOLECULES UNDERGOING ENZYMATIC DEGRADATION IN FLUID Reviewed

    Daisuke Onoshima, Noritada Kaji, Manabu Tokeshi and Yoshinobu Baba

    Micro Total Analysis System 2010     page: 1437-1439   2010.10

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  572. REAL-TIME OBSERVATION OF DNA COMFORMATIONAL TRANSITIONS AT A SINGLE-MOLECULE LEVEL BY MICROFLUIDIC DEVICES Reviewed

    Hiroshi Suzuki, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi and Yoshinobu Baba

    Micro Total Analysis System 2010     page: 1880-1882   2010.10

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  573. MICROFLUIDIC SENSOR FOR THE DETECTION OF DNA OR PROTEIN BY HYBRIDIZATION-BASED FLUORESCENCE ENHANCEMENT OR IMMUNOASSAY-BASED FLUORESCENCE QUENCHING Reviewed

    Jun Wang, Michihiko Aki, Daisuke Onoshima, Kenji Arinaga, Noritada Kaji, Manabu Tokeshi, Shozo Fujita, Naoki Yokoyama, and Yoshinobu Baba

    Micro Total Analysis System 2010     page: 1514-1516   2010.10

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