研究者詳細 - 益谷　央豪

論文 - 益谷　央豪

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Structure and mechanism of human DNA polymerase h. 査読有り

Biertümpfel, C., Zhao, Y., Kondo, Y., Ramón-Maiques, S., Gregory, M., Lee, J.Y., Masutani, C., Lehmann, A. R., *Hanaoka, F., and *Yang, W.

Nature 465 巻頁： 1044-1048 2010年6月

Polymerization by DNA polymerase h is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) crosslink: Implications for cytotoxic effects in nucleotide excision repair-negative tumor cells. 査読有り

Chijiwa, S., Masutani, C., Hanaoka, F., Iwai, S., and *Kuraoka, I.

Carcinogenesis 31 巻頁： 388-393 2010年3月

Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells.

Chijiwa S, Masutani C, Hanaoka F, Iwai S, Kuraoka I

Carcinogenesis 31 巻 ( 3 ) 頁： 388 - 93 2010年3月

The Molecular Chaperone Hsp90 Regulates Accumulation of DNA Polymerase eta at Replication Stalling Sites in UV-Irradiated Cells

Sekimoto Takayuki, Oda Tsukasa, Pozo Franklin Mayca, Murakumo Yoshiki, Masutani Chikahide, Hanaoka Fumio, Yamashita Takayuki

MOLECULAR CELL 37 巻 ( 1 ) 頁： 79 - 89 2010年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Molecular Cell

DNA polymerase η (Pol η) is a member of the mammalian Y family polymerases and performs error-free translesion synthesis across UV-damaged DNA. For this function, Pol η accumulates in nuclear foci at replication stalling sites via its interaction with monoubiquitinated PCNA. However, little is known about the posttranslational control mechanisms of Pol η, which regulate its accumulation in replication foci. Here, we report that the molecular chaperone Hsp90 promotes UV irradiation-induced nuclear focus formation of Pol η through control of its stability and binding to monoubiquitinated PCNA. Our data indicate that Hsp90 facilitates the folding of Pol η into an active form in which PCNA- and ubiquitin-binding regions are functional. Furthermore, Hsp90 inhibition potentiates UV-induced cytotoxicity and mutagenesis in a Pol η-dependent manner. Our studies identify Hsp90 as an essential regulator of Pol η-mediated translesion synthesis. © 2010 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.molcel.2009.12.015

Web of Science

Scopus

PubMed

Critical amino acids involved in erroneous incorporation of oxidized nucleotides by human DNA polymerase h and k. 査読有り

Katafuchi, A., Sassa, A., Niimi, N., Gruz, P., Fujimoto, H., Masutani, C., Hanaoka, F., Ohta, T., and *Nohmi, T.

Nucl. Acids Res. 38 巻頁： 859-867 2010年1月

The molecular chaperone Hsp90 regulates accumulation of DNA polymerase h at replication stalling sites in UV-irradiated cells. 査読有り

Sekimoto, T., Oda, T., Pozo, F. M., Murakumo, Y., Masutani, C., Hanaoka, F., and *Yamashita, T.

Mol. Cell 37 巻頁： 79-89 2010年1月

Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides.

Katafuchi A, Sassa A, Niimi N, Grúz P, Fujimoto H, Masutani C, Hanaoka F, Ohta T, Nohmi T

Nucleic acids research 38 巻 ( 3 ) 頁： 859 - 67 2010年1月

A novel interaction between human DNA polymerase h and MutLa. 査読有り

Kanao, R., Hanaoka, F., and *Masutani, C.

Biochem. Biophys. Res. Commun. 389 巻頁： 40-45 2009年11月

Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in vitro: REV1 inserts dC opposite the lesion and DNA polymerase k potentially catalyzes extension reaction from the 3'-dC terminus. 査読有り

Fukuda, H., Takamura-Enya, T., Masuda, Y., Nohmi, T., Seki, C., Kamiya, K., Sugimura, T., Masutani, C., Hanaoka, F., and *Nakagama, H.

J. Biol. Chem. 284 巻頁： 25585-25592 2009年9月

Interaction with DNA polymerase h is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells. 査読有り

Akagi, J., *Masutani, C., Kataoka, Y., Kan, T., Ohashi, E., Mori, T., Ohmori, H., and Hanaoka, F.

DNA Repair 8 巻頁： 585-599 2009年5月

Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases. 査読有り

Kimura, T., Takeuchi, T., Kumamoto-Yonezawa, Y., Ohashi, E., Ohmori, H., Masutani, C., Hanaoka, F., Sugawara, F., Yoshida, H., and *Mizushina, Y.

Bioorg. Medicinal Chem. 17 巻頁： 1811-1816 2009年3月

Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase h. 査読有り

Hidaka, K., Yamada, M., Kamiya, H., Masutani, C., Harashima, H., Hanaoka, F., and *Nohmi, T.

DNA Repair 7 巻頁： 497-506 2008年

Miscoding property of 2'-deoxyinosine, a nitric oxide-derived DNA adduct, during translesion synthesis catalyzed by human DNA polymerases. 査読有り

*Yasui, M., Suenaga, E., Koyama, N., Masutani, C., Hanaoka, F., Gruz, P., Shibutani, S., Nohmi, T., Hayashi, M., and Honma, M.

J. Mol. Biol. 377 巻頁： 1015-1023 2008年

Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase h. 査読有り

Shimizu, M., Gruz, P., Kamiya, H., Masutani, C., Xu, Y., Sugiyama, H., Harashima, H., Hanaoka, F., and Nohmi, T.

Biochemistry 46 巻頁： 5515-5522 2007年

A second PCNA loader complex, Ctf18-RFC, specifically stimulates DNA polymerase h activity. 査読有り

Shiomi, Y., Masutani, C., Hanaoka, F., Kimura, H., and *Tsurimoto, T.

J. Biol. Chem. 282 巻頁： 20906-20914 2007年

2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract. 査読有り

Satou, K., Kasai, H., Masutani, C., Hanaoka, F., Harashima, H., and Kamiya, H.

Biochemistry 46 巻頁： 6639-6646 2007年

DNA polymerase h and q function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. 査読有り

Masuda, K., Ouchida, R., Hikida, M., Kurosaki, T., Yokoi, M., Masutani, C., Seki, M., Wood, R.D., Hanaoka, F., and O-Wang, J.

J. Biol. Chem. 282 巻頁： 17387-17394 2007年

Deficiency of the Caenorhabditis elegans DNA polymerase h homologue increases sensitivity to UV radiation during germ-line development. 査読有り

Ohkumo, T., Masutani, C., Eki, T., and Hanaoka, F.

Cell Struct. Funct. 31 巻頁： 29-37 2006年

Ultraviolet B radiation induces epithelial tumors in mice lacking Polh and mesenchymal tumors in mice deficient for Poli. 査読有り

Ohkumo, T., Kondo, Y., Yokoi, M., Tsukamoto, T., Yamada, A., Sugimoto, T., Kanao, R., Higashi, Y., Kondoh, H., Tatematsu, M., Masutani, C., and Hanaoka, F.

Mol. Cell. Biol. 26 巻頁： 7696-7706 2006年

A human DNA polymerase h complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. 査読有り

Yuasa S., M., Masutani, C., Hirano, A., Cohn, M.A., Yamaizumi, M., Nakatani, Y., and Hanaoka, F.

Genes Cells 11 巻頁： 731-744 2006年

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