Updated on 2021/11/02

写真a

 
YAMADA, Kiyofumi
 
Organization
Nagoya University Hospital Department of Hospital Pharmacy Professor
Graduate School
Graduate School of Medicine
Title
Professor

Degree 1

  1. Doctor of Pharmaceutical Science ( 1991.11   Meijo University ) 

Research Interests 1

  1. Neuropsychopharmacology

Research Areas 3

  1. Others / Others  / Nerve Chemistry/Nerve Pharmacology

  2. Others / Others  / General Pharmacology

  3. Others / Others  / Clinical Pharmaceutical Science

Current Research Project and SDGs 4

  1. 痴呆症の病態解析と治療薬の開発研究

  2. 統合失調症の病態解析と治療薬の開発研究

  3. 薬物依存の分子機構

  4. Neuronal Mechanism of Learning and Memory

Research History 11

  1. Nagoya University

    2007.9

  2. 名古屋大学医学部附属病院 教授・薬剤部長,大学院医学系研究科医療薬学を担当

    2007.8

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    Country:Japan

  3. 金沢大学薬学部薬学科長

    2006.4 - 2007.7

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    Country:Japan

  4. 金沢大学大学院自然科学研究科 教授

    2004.4 - 2007.7

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    Country:Japan

  5. 金沢大学薬学部 教授

    2002.4 - 2004.3

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    Country:Japan

  6. Nagoya University

    1998.10 - 2002.3

  7. 名古屋大学医学部附属病院 助教授・副薬剤部長

    1998.6 - 2002.3

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    Country:Japan

  8. Nagoya University

    1998.6 - 2002.3

  9. 名古屋大学医学部附属病院薬剤部 文部技官薬剤師

    1993.4 - 2002.3

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    Country:Japan

  10. 米国ジョンズホプキンス大学医学部 訪問研究員

    1987.4 - 1989.5

  11. 大塚製薬株式会社徳島研究所 研究員

    1983.4 - 1993.3

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    Country:Japan

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Education 2

  1. Meijo University   Graduate School, Division of Pharmaceutical Sciences

    1981.4 - 1983.3

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    Country: Japan

  2. Meijo University   Faculty of Pharmaceutical Science

    1977.4 - 1981.3

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    Country: Japan

Professional Memberships 13

  1. International Drug Abuse Research Society (IDARS)   Board Member

    2008.1

  2. 日本医療薬学会   理事

    2003.4 - 2012.3

  3. 日本神経精神薬理学会   理事、評議員

    1996.1

  4. 日本薬理学会   理事、学術評議員

    1992.4 - 2010.3

  5. 日本神経精神薬理学会   理事

    2008.4

  6. 日本薬学会   医療薬科学部会世話人

    2008.4

  7. 日本薬学会   東海支部幹事

    2007.4 - 2011.1

  8. 日本神経化学会   評議員

    1999.4

  9. 日本神経精神薬理学会   理事

    2020.10

  10. 日本依存神経精神科学会   評議員

    2014.9 - 2015.10

  11. 日本病院薬剤師会   理事

    2014.7 - 2016.6

  12. Asian College of Neuropsychopharmacology(AsCNP)   Council member

    2011.4 - 2013.3

  13. 愛知県病院薬剤師会   副会長

    2009.4 - 2015.5

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Awards 2

  1. 平成20年度日本薬学会学術振興賞

    2008.3   日本薬学会  

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    Country:Japan

  2. 第12回日本薬理学会学術奨励賞

    1997.3   日本薬理学会  

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    Country:Japan

 

Papers 421

  1. Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks. Reviewed

    Liao,JZ,Dong,GY,Wulaer B,Sawahata M,Mizoguchi H,Mori D,Ozaki N,Nabeshima T,Nagai T,Yamada K.

    BEHAVIOURAL BRAIN RESEARCH.   Vol. 416 ( 7 )   2022.1

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  2. Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice Reviewed

    Mizoguchi A,Banno R,Sun R,Yaginuma H,Taki K,Kobayashi T,Sugiyama M,Tsunekawa T,Onoue T,Takagi H,Hagiwara D,Ito Y,Iwama S,Suga H,Nagai T,Yamada K,Arima H.

    Scientific Report   Vol. 11 ( 1 )   2021.6

  3. Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia. Reviewed

    Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K

    Neurochemistry international   Vol. 144   page: 104954   2021.3

  4. Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway Reviewed

    Lin You-Hsin, Yamahashi Yukie, Kuroda Keisuke, Faruk Omar, Zhang Xinjian, Yamada Kiyofumi, Yamanaka Akihiro, Nagai Taku, Kaibuchi Kozo

    NEUROCHEMISTRY INTERNATIONAL   Vol. 143   page: 104935   2021.2

  5. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons Reviewed

    Hada Kazuhiro, Wulaer Bolati, Nagai Taku, Itoh Norimichi, Sawahata Masahito, Sobue Akira, Mizoguchi Hiroyuki, Mori Daisuke, Kushima Itaru, Nabeshima Toshitaka, Ozaki Norio, Yamada Kiyofumi

    MOLECULAR BRAIN   Vol. 14 ( 1 ) page: 21   2021.1

  6. Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice Reviewed

    Wulaer Bolati, Hada Kazuhiro, Sobue Akira, Itoh Norimichi, Nabeshima Toshitaka, Nagai Taku, Yamada Kiyofumi

    MOLECULAR BRAIN   Vol. 13 ( 1 ) page: 170   2020.12

  7. Short hydration with 20 mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy: a prospective study Reviewed

    Hase Tetsunari, Miyazaki Masayuki, Ichikawa Kazuya, Yogo Naoyuki, Ozawa Naoya, Hatta Takahiro, Ando Masahiko, Sato Mitsuo, Kondo Masashi, Yamada Kiyofumi, Hasegawa Yoshinori

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 11 ) page: 1928 - 1935   2020.11

  8. Reelin Supplementation Into the Hippocampus Rescues Abnormal Behavior in a Mouse Model of Neurodevelopmental Disorders Reviewed

    Ibi Daisuke, Nakasai Genki, Koide Nayu, Sawahata Masahito, Kohno Takao, Takaba Rika, Nagai Taku, Hattori Mitsuharu, Nabeshima Toshitaka, Yamada Kiyofumi, Hiramatsu Masayuki

    FRONTIERS IN CELLULAR NEUROSCIENCE   Vol. 14   page: 285   2020.9

  9. Comparing incidences of infusion site reactions between brand-name and generic vinorelbine in patients with non-small cell lung cancer Reviewed

    Ozawa Naoya, Hase Tetsunari, Hatta Takahiro, Sagara Atsunobu, Ichikawa Kazuya, Miyazaki Masayuki, Yogo Naoyuki, Ando Masahiko, Hashimoto Naozumi, Yamada Kiyofumi, Hasegawa Yoshinori

    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY   Vol. 87 ( 3 ) page: 1318 - 1326   2020.8

  10. Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days Reviewed

    Sato Yoshitaka, Iguchi Mitsutaka, Kato Yoshiaki, Morioka Hiroshi, Hirabayashi Aki, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yamada Kiyofumi, Kimura Hiroshi, Yagi Tetsuya

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page: 407 - 414   2020.8

  11. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk Reviewed

    Sekiguchi Mariko, Sobue Akira, Kushima Itaru, Wang Chenyao, Arioka Yuko, Kato Hidekazu, Kodama Akiko, Kubo Hisako, Ito Norimichi, Sawahata Masahito, Hada Kazuhiro, Ikeda Ryosuke, Shinno Mio, Mizukoshi Chikara, Tsujimura Keita, Yoshimi Akira, Ishizuka Kanako, Takasaki Yuto, Kimura Hiroki, Xing Jingrui, Yu Yanjie, Yamamoto Maeri, Okada Takashi, Shishido Emiko, Inada Toshiya, Nakatochi Masahiro, Takano Tetsuya, Kuroda Keisuke, Amano Mutsuki, Aleksic Branko, Yamomoto Takashi, Sakuma Tetsushi, Aida Tomomi, Tanaka Kohichi, Hashimoto Ryota, Arai Makoto, Ikeda Masashi, Iwata Nakao, Shimamura Teppei, Nagai Taku, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi, Mori Daisuke, Ozaki Norio

    TRANSLATIONAL PSYCHIATRY   Vol. 10 ( 1 ) page: 247   2020.7

  12. AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication Reviewed

    Hori Kei, Yamashiro Kunihiko, Nagai Taku, Shan Wei, Egusa Saki F., Shimaoka Kazumi, Kuniishi Hiroshi, Sekiguchi Masayuki, Go Yasuhiro, Tatsumoto Shoji, Yamada Mitsuyo, Shiraishi Reika, Kanno Kouta, Miyashita Satoshi, Sakamoto Asami, Abe Manabu, Sakimura Kenji, Sone Masaki, Sohya Kazuhiro, Kunugi Hiroshi, Wada Keiji, Yamada Mitsuhiko, Yamada Kiyofumi, Hoshino Mikio

    ISCIENCE   Vol. 23 ( 6 ) page: 101183   2020.6

  13. Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus Reviewed

    Wulaer Bolati, Kunisawa Kazuo, Hada Kazuhiro, Suento Willy Jaya, Kubota Hisayoshi, Iida Tsubasa, Kosuge Aika, Nagai Taku, Yamada Kiyofumi, Nitta Atsumi, Yamamoto Yasuko, Saito Kuniaki, Mouri Akihiro, Nabeshima Toshitaka

    JOURNAL OF NEUROCHEMISTRY     2020.5

  14. Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia Reviewed

    Sawahata Masahito, Mori Daisuke, Arioka Yuko, Kubo Hisako, Kushima Itaru, Kitagawa Kanako, Sobue Akira, Shishido Emiko, Sekiguchi Mariko, Kodama Akiko, Ikeda Ryosuke, Aleksic Branko, Kimura Hiroki, Ishizuka Kanako, Nagai Taku, Kaibuchi Kozo, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 74 ( 5 ) page: 318 - 327   2020.5

  15. Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus Reviewed

    Saito Ryo, Koebis Michinori, Nagai Taku, Shimizu Kimiko, Liao Jingzhu, Wulaer Bolati, Sugaya Yuki, Nagahama Kenichiro, Uesaka Naofumi, Kushima Itaru, Mori Daisuke, Maruyama Kazuaki, Nakao Kazuki, Kurihara Hiroki, Yamada Kiyofumi, Kano Masanobu, Fukada Yoshitaka, Ozaki Norio, Aiba Atsu

    TRANSLATIONAL PSYCHIATRY   Vol. 10 ( 1 ) page: 35   2020.2

  16. Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors

    Funahashi Yasuhiro, Ariza Anthony, Emi Ryosuke, Xu Yifan, Shan Wei, Suzuki Ko, Kozawa Sachi, Ahammad Rijwan Uddin, Wu Mengya, Takano Tetsuya, Yura Yoshimitsu, Kuroda Keisuke, Nagai Taku, Amano Mutsuki, Yamada Kiyofumi, Kaibuchi Kozo

    CELL REPORTS   Vol. 29 ( 10 ) page: 3235 - +   2019.12

  17. Effects of Renal Function Evaluation with or without Serum Creatinine Adjustment on Cisplatin/Fluorouracil Therapy for Cervical Cancer

    Takagi Mai, Sagara Atsunobu, Ishizawa Ayumi, Ito Ayaka, Miyazaki Masayuki, Senzaki Kouji, Nagai Taku, Yamada Kiyofumi

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   Vol. 139 ( 10 ) page: 1327 - 1332   2019.10

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  18. Pharmacological and proteomic analyses of neonatal polyI:C-treated adult mice

    Kitagawa Kanako, Nagai Taku, Yamada Kiyofumi

    NEUROSCIENCE RESEARCH   Vol. 147   page: 39 - 47   2019.10

  19. Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration

    Uchida Mizuki, Hida Hirotake, Mori Kentaro, Yoshimi Akira, Kitagaki Shinji, Yamada Kiyofumi, Hiraoka Yuichi, Aida Tomomi, Tanaka Kohichi, Ozaki Norio, Noda Yukihiro

    EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 29 ( 8 ) page: 914 - 924   2019.8

  20. Methylation analysis for postpartum depression: a case control study

    Nakamura Yukako, Nakatochi Masahiro, Kunimoto Shohko, Okada Takashi, Aleksic Branko, Toyama Miho, Shiino Tomoko, Morikawa Mako, Yamauchi Aya, Yoshimi Akira, Furukawa-Hibi Yoko, Nagai Taku, Ohara Masako, Kubota Chika, Yamada Kiyofumi, Ando Masahiko, Ozaki Norio

    BMC PSYCHIATRY   Vol. 19 ( 1 ) page: 190   2019.6

  21. Exploring Molecular Targets for Epilepsy Treatment from the Perspective of Neuronal Homeostasis

    Nagai Taku, Shan Wei, Yamada Kiyofumi

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   Vol. 139 ( 6 ) page: 923 - 929   2019.6

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  22. Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

    Yoshimi Akira, Yamada Shinnosuke, Kunimoto Shohko, Aleksic Branko, Hirakawa Akihiro, Ohashi Mitsuki, Matsumoto Yurie, Hada Kazuhiro, Itoh Norimichi, Arioka Yuko, Kimura Hiroki, Kushima Itaru, Nakamura Yukako, Shiino Tomoko, Mori Daisuke, Tanaka Satoshi, Hamada Shuko, Noda Yukihiro, Nagai Taku, Yamada Kiyofumi, Ozaki Norio

    TRANSLATIONAL PSYCHIATRY   Vol. 9 ( 1 ) page: 126   2019.4

  23. Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

    Hasegawa Sho, Yoshimi Akira, Mouri Akihiro, Uchida Yoji, Hida Hirotake, Mishina Masayoshi, Yamada Kiyofumi, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

    NEUROPHARMACOLOGY   Vol. 148   page: 107 - 116   2019.4

  24. Methamphetamine use causes cognitive impairment and altered decision-making

    Mizoguchi Hiroyuki, Yamada Kiyofumi

    NEUROCHEMISTRY INTERNATIONAL   Vol. 124   page: 106 - 113   2019.3

  25. Nicotine and varenicline ameliorate changes in reward-based choice strategy and altered decision-making in methamphetamine-treated rats

    Mizoguchi Hiroyuki, Wang Tian, Kusaba Mizuki, Fukumoto Kazuya, Yamada Kiyofumi

    BEHAVIOURAL BRAIN RESEARCH   Vol. 359   page: 935 - 941   2019.2

  26. Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons

    Zhang Xinjian, Nagai Taku, Ahammad Rijwan Uddin, Kuroda Keisuke, Nakamuta Shinichi, Nakano Takashi, Yukinawa Naoto, Funahashi Yasuhiro, Yamahashi Yukie, Amano Mutsuki, Yoshimoto Junichiro, Yamada Kiyofumi, Kaibuchi Kozo

    NEUROCHEMISTRY INTERNATIONAL   Vol. 122   page: 8 - 18   2019.1

  27. Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1(Delta 2-3/Delta 2-3) mice

    Wulaer B., Nagai T., Sobue A., Itoh N., Kuroda K., Kaibuchi K., Nabeshima T., Yamada K.

    GENES BRAIN AND BEHAVIOR   Vol. 17 ( 8 )   2018.11

  28. Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3. Reviewed

    Yamada S, Itoh N, Nagai N, Nakai T, Ibi D, Nakajima A, Nabeshima T, Yamada K.

    J Neuroimmunol.   Vol. 15 ( 1 ) page: 295   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12974-018-1332-0.

  29. Short Hydration Regimen with a Modified Dose of Magnesium Supplementation for Lung Cancer Patients Receiving Cisplatin-Based Chemotherapy

    Hase T., Miyazaki M., Ichikawa K., Yogo N., Ozawa N., Ando M., Morise M., Sato M., Kondo M., Yamada K., Hasegawa Y.

    JOURNAL OF THORACIC ONCOLOGY   Vol. 13 ( 10 ) page: S880 - S880   2018.10

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  30. Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice

    Bin Saifullah Md. Ali, Nagai Taku, Kuroda Keisuke, Wulaer Bolati, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 14413   2018.9

  31. Dysfunction of serotoninergic and dopaminergic neuronal systems in the antidepressant-resistant impairment of social behaviors induced by social defeat stress exposure as juveniles. Reviewed

    Hasegawa S, Miyake Y, Yoshimi A, Mouri A, Hida H, Yamada K, Ozaki N, Nabeshima T, Noda Y

    The international journal of neuropsychopharmacology   Vol. 21 ( 9 ) page: 837 - 846   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ijnp/pyy038

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  32. Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia. Reviewed

    Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N

    Scientific reports   Vol. 8 ( 1 ) page: 13046   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-31390-w

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  33. Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis Reviewed

    Mouri Akihiro, Ukai Mayu, Uchida Mizuki, Hasegawa Sho, Taniguchi Masayuki, Ito Takahiro, Hida Hirotake, Yoshimi Akira, Yamada Kiyofumi, Kunimoto Shohko, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

    NEUROPHARMACOLOGY   Vol. 133   page: 23-37   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuropharm.2018.01.016

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  34. Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes Reviewed

    Sobue Akira, Ito Norimichi, Nagai Taku, Shan Wei, Hada Kazuhiro, Nakajima Akira, Murakami Yuki, Mouri Akihiro, Yamamoto Yasuko, Nabeshima Toshitaka, Saito Kuniaki, Yamada Kiyofumi

    GLIA   Vol. 66 ( 5 ) page: 1034 - 1052   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/glia.23299

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  35. Protein Kinase C delta Gene Depletion Protects Against Methamphetamine-Induced Impairments in Recognition Memory and ERK1/2 Signaling via Upregulation of Glutathione Peroxidase-1 Gene Reviewed

    The-Vinh Tran, Shin Eun-Joo, Lan Thuy Ty Nguyen, Lee Youngho, Kim Dae-Joong, Jeong Ji Hoon, Jang Choon-Gon, Nah Seung-Yeol, Toriumi Kazuya, Nabeshima Toshitaka, Yamada Kiyofumi, Kim Hyoung-Chun

    MOLECULAR NEUROBIOLOGY   Vol. 55 ( 5 ) page: 4136-4159   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12035-017-0638-8

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  36. Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy.

    Tajima H, Izumi T, Miyachi S, Matsubara N, Ito M, Imai T, Nishihori M, Shintai K, Okamoto S, Araki Y, Kumakura Y, Furukawa-Hibi Y, Yamada K, Wakabayashi T

    Nagoya journal of medical science   Vol. 80 ( 2 ) page: 207 - 215   2018.5

  37. Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a Reviewed

    Shan Wei, Nagai Taku, Tanaka Motoki, Itoh Norimichi, Furukawa-Hibi Yoko, Nabeshima Toshitaka, Sokabe Masahiro, Yamada Kiyofumi

    JOURNAL OF NEUROCHEMISTRY   Vol. 145 ( 1 ) page: 19 - 33   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jnc.14274

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  38. Efficacy of Prophylactic Treatment for Oxycodone-Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo-Controlled, Double-Blind Trial Reviewed

    Tsukuura Hiroaki, Miyazaki Masayuki, Morita Tatsuya, Sugishita Mihoko, Kato Hiroshi, Murasaki Yuka, Gyawali Bishal, Kubo Yoko, Ando Masahiko, Kondo Masashi, Yamada Kiyofumi, Hasegawa Yoshinori, Ando Yuichi

    ONCOLOGIST   Vol. 23 ( 3 ) page: 367 - 374   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1634/theoncologist.2017-0225

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  39. Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice Reviewed

    Phuong-Tram Nguyen, Shin Eun-Joo, Dang Duy-Khanh, Tran Hai-Quyen, Jang Choon-Gon, Jeong Ji Hoon, Lee Yu Jeung, Lee Hyo Jong, Lee Yong Sup, Yamada Kiyofumi, Nabeshima Toshitaka, Kim Hyoung-Chun

    NEUROCHEMISTRY INTERNATIONAL   Vol. 113   page: 69-84   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuint.2017.11.017

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  40. Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein Reviewed

    Itoh Norimichi, Nagai Taku, Watanabe Takashi, Taki Kentaro, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 493 ( 4 ) page: 1384 - 1389   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2017.09.159

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  41. MK-801, but not naloxone, attenuates high-dose dextromethorphan-induced convulsive behavior: Possible involvement of the GluN2B receptor

    Hai-Quyen Tran, Chung Yoon Hee, Shin Eun-Joo, The-Vinh Tran, Jeong Ji Hoon, Jang Choon-Gon, Nah Seung-Yeol, Yamada Kiyofumi, Nabeshima Toshitaka, Kim Hyoung-Chun

    TOXICOLOGY AND APPLIED PHARMACOLOGY   Vol. 334   page: 158 - 166   2017.11

  42. Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice Reviewed

    The-Vinh Tran, Shin Eun-Joo, Jeong Ji Hoon, Lee Ji Won, Lee Youngho, Jang Choon-Gon, Nah Seung-Yeol, Lei Xin Gen, Toriumi Kazuya, Yamada Kiyofumi, Nabeshima Toshitaka, Kim Hyoung-Chun

    MOLECULAR NEUROBIOLOGY   Vol. 54 ( 9 ) page: 7042-7062   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12035-016-0239-y

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  43. A new nomenclature for classifying psychotropic drugs Reviewed

    Caraci Filippo, Enna Sam J., Zohar Joseph, Racagni Giorgio, Zalsman Gil, van den Brink Wim, Kasper Siegfried, Koob George F., Pariante Carmine M., Piazza Pier Vincenzo, Yamada Kiyofumi, Spedding Michael, Drago Filippo

    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY   Vol. 83 ( 8 ) page: 1614-1616   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/bcp.13302

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  44. The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization. Reviewed

    Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T

    Behavioural Brain Research     page: 157-165   2017.6

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  45. Incidence of and risk factors associated with nedaplatin-related hypersensitivity reactions

    Kawarada Yuki, Miyazaki Masayuki, Itoh Ayaka, Araki Risa, Iwamizu Hidetaka, Kataoka Tomomi, Kumakura Yasuo, Ota Akiko, Nagai Taku, Yamada Kiyofumi

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 22 ( 3 ) page: 593 - 599   2017.6

  46. Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice. Reviewed

    Konishi H, Ohgami N, Matsushita A, Kondo Y, Aoyama Y, Kobayashi M, Nagai T, Ugawa S, Yamada K, Kato M, Kiyama H

    Neuroscience   Vol. 351   page: 15-23   2017.5

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    DOI: 10.1016/j.neuroscience.2017.03.028

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  47. Association of impaired neuronal migration with cognitive deficits in extremely preterm infants Reviewed

    Kubo Ken-Ichiro, Deguchi Kimiko, Nagai Taku, Ito Yukiko, Yoshida Keitaro, Endo Toshihiro, Benner Seico, Shan Wei, Kitazawa Ayako, Aramaki Michihiko, Ishii Kazuhiro, Shin Minkyung, Matsunaga Yuki, Hayashi Kanehiro, Kakeyama Masaki, Tohyama Chiharu, Tanaka Kenji F., Tanaka Kohichi, Takashima Sachio, Nakayama Masahiro, Itoh Masayuki, Hirata Yukio, Antalffy Barbara, Armstrong Dawna D., Yamada Kiyofumi, Inoue Ken, Nakajima Kazunori

    JCI INSIGHT   Vol. 2 ( 10 )   2017.5

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    DOI: 10.1172/jci.insight.88609

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  48. Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors Reviewed

    Shin Eun-Joo, Duy-Khanh Dang, The-Vinh Tran, Hai-Quyen Tran, Jeong Ji Hoon, Nah Seung-Yeol, Jang Choon-Gon, Yamada Kiyofumi, Nabeshima Toshitaka, Kim Hyoung-Chun

    ARCHIVES OF PHARMACAL RESEARCH   Vol. 40 ( 4 ) page: 403-428   2017.4

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    DOI: 10.1007/s12272-017-0897-y

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  49. [Analysis of Nedaplatin Dose in Patients with Impaired Renal Function]. Reviewed

    Araki R, Iwamizu H, Kataoka T, Kumakura Y, Miyazaki M, Nagai T, Ando Y, Yamada K

    Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 44 ( 2 ) page: 143-147   2017.2

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  50. Risk factors for postoperative delirium in abdominal surgery: a proposal of a postoperative delirium risk score in abdominal surgery. Reviewed

    Miyagawa Y, Yokoyama Y, Fukuzawa S, Fukata S, Ando M, Kawamura T, Yamada K, Nagino M.

    Digestive Surgery     page: 95-102   2017

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  51. Phospho-proteomics of the dopamine pathway enables discovery of Rap1 activation as a reward signal in vivo. Reviewed

    Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K.

    Neuron   Vol. 89   page: 550-565   2016

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  52. Molecular mechanism linking BDNF/TrkB signaling with the NMDA receptor in memory: The role of Girdin in the CNS. Reviewed

    Itoh N, Enomoto A, Nagai T, Takahashi M, Yamada K

    Rev Neurosci.   Vol. 27   page: 481-90   2016

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  53. Association of axitinib plasma exposure and genetic polymorphisms of ABC transporters with axitinib-induced toxicities in patients with renal cell carcinoma. Reviewed

    Kato H, Sassa N, Miyazaki M, Takeuchi M, Asai M, Iwai A, Noda Y, Gotoh M, Yamada K.

    Cancer Chemother. Pharmacol.   Vol. 78   page: 855-862   2016

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  54. Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease. Reviewed

    Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, ueda M, Yamamoto A

    Behav Brain Res   Vol. 293   page: 189-197   2015.10

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  55. Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease(3XTg-AD). Reviewed

    Nakajima A, Aoyama Y, Shin EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi T, Ohizumi Y, Yamada K

      Vol. 289   page: 69-77   2015.8

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  56. A retrospective study to identify risk factors for somenolence and dizziness in patients treated with pregabalin. Reviewed

    Hiroshi Kato, Masayuki Miyazaki, Mio Takeuchi, Hiroaki Tsukuura, Mihoko Sugishita, Yukihiro Noda, Kiyofumi Yamada.

    J.Pharm.Health Care Sci.     2015.7

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    DOI: 10.1186/s40780-015-0022-7

  57. Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene. Reviewed

    Yoko Furukawa-Hibi, Taku Nagai, Jaesuk Yun, Kiyofumi Yamada

    Neuroreport.     2015.7

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    DOI: 10.1097/wNR0000000000000430

  58. Insular neural system controls decision-making in healthy and methamphetamine-treated rats. Reviewed

    Hiroyuki Mizoguchi, Kentaro Katahira, Ayumu Inutsuka, Kazuya Fukumoto, Akihiro Nakamura, Tian Wang, Taku Nagai, Jun Sato, Makoto Sawade, Hideki Ohira, Akihiro Yamanaka, Kiyofumi Yamada

    Proc. Natl. Acad. Sci. USA.     page: 3930-3939   2015.7

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    DOI: 10.1073/pnas.1418014112

  59. Prenatal nicotine exposure impairs the proliferation of neuronal progenitors, leading to fewer glutamatergic neurons in the medial prefrontal cortex. Reviewed

    Yuki Aoyama, Kazuya Toriumi, Akihiro Mouri, Tomoya Hattori, Eriko Ueda, Akane Shimato, Nami Sakakibara, Yuka Soh, Takayoshi Mamiya, Taku Nagai, Hyoung-Chun Kim, Masayuki Hiramatsu, Toshitaka Nabeshima, Kiyofumi Yamada

    Neuropsychopharmacology     page: 1-12   2015.6

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  60. FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization. Reviewed

    Tsuyoshi Udagawa, Yusuke Fujioka, Motoki Tanaka, Daiyu Honda, Satoshi Yokoi, Yuichi Riku, Daisuke Ibi, Taku Nagai, Kiyofumi Yamada, Hirohisa Watanabe, Masahisa Katsuno, Toshifumi Inada, Kinji Ohno, Masahiro Sokabe, Haruo Okado, Shinsuke Ishigaki, Gen Sobue

    Nature Communications     2015.5

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    DOI: 10.1038/ncomms8098

  61. A successful case of a patient undergoing warfarin and S-1 therapy using Internet-based control of home-measured PT-INR. Reviewed

    Keiko Yamamura, Koji Yano, Yoshiki Hirooka, Akihiro Hirashiki, Toyoaki Murohara, Kiyofumi Yamada

    YAKUGAKU ZASSHI.   Vol. 135 ( 7 ) page: 925-927   2015.4

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  62. Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: The Complex Mechanism of Blonanserin Action Involving D3-5-HT2A and D1-NMDA Receptors in the mPFC. Reviewed

    Hirotake Hida, Akihiro Mouri, Kentaro Mori, Yurie Matsumoto, Takeshi Seki, Masayuki Taniguchi, Kiyofumi Yamada, Kunihiro Iwamoto, Norio Ozaki, Toshitaka Nabeshima, Yukihiro Noda

    Neuropsychopharmacology   Vol. 40 ( 3 ) page: 601-613   2015.2

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  63. Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits. Reviewed

    Kazuhiro Ishii, Taku Nagai, Yuki Hirota, Mariko Noda, Toshitaka Nabeshima, Kiyofumi Yamada, Ken-ichiro Kubo, Kazunori Nakajima

    Neurosci. Res.   Vol. 96 ( 2015 ) page: 30-36   2015.1

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  64. Pharmacist-managed clinics for patient education and counseling in Japan: current status and future perspectives. Reviewed

    Kiyofumi Yamada, Toshitaka Nabeshima

    J.Pharm.Health Care Sci.     2015.1

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    DOI: 10.1186/s40780-014-0001-4

  65. Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes. Reviewed

    Akira Nakajima, Daisuke Ibi, Taku Nagai, Shinnosuke Yamada, Toshitaka Nabeshima, Kiyofumi Yamada

    European Journal of Pharmacology   Vol. 745   page: 166-175   2014.12

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  66. Cytoskeletal Regulation by AUTS2 in Neuronal Migration and Neuritogenesis. Reviewed

    Kei Hori , Taku Nagai , Wei Shan , Asami Sakamoto , Shinichiro Taya , Ryoya Hashimoto , Takashi Hayashi , Manabu Abe , Maya Yamazaki , Keiko Nakao , Tomoki Nishioka , Kenji Sakimura , Kiyofumi Yamada , Kozo Kaibuchi , Mikio Hoshino

    Cell Reports   Vol. 9   page: 2166-2179   2014.12

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  67. Girdin Phosphorylation Is Crucial for Synaptic Plasticity and Memory: A Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor. Reviewed

    Tsuyoshi Nakai, Taku Nagai, Motoki Tanaka, Norimichi Itoh, Naoya Asai, Atsushi Enomoto, Masato Asai, Shinnosuke Yamada, Ali Bin Saifullah, Masahiro Sokabe, Masahide Takahashi, Kiyofumi Yamada

    The Journal of Neuroscience   Vol. 34 ( 45 ) page: 14995-15008   2014.11

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  68. Clinical relevance of post-transplant pharmacodynamics analysis of cyclosporine in transplantation. Reviewed

    Kurata Y, Kuzuya T, Miwa Y, Iwasaki K, Haneda M, Amioka K, Yamada K, Watari Y, Katayama A, Uchida K, Kobayashi T

    Int. Immunophamacol   Vol. 22 ( 2 ) page: 384-391   2014.10

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  69. Npas4 Regulates Mdm2 and thus Dcx in Experience-Dependent Dendritic Spine Development of Newborn Olfactory Bulb Interneurons. Reviewed

    Sei-ichi Yoshihara, Hiroo Takahashi, Nobushiro Nishimura, Masahito Kinoshita, Ryo Asahina, Michiko Kitsuki, Kana Tatsumi, Yoko Furukawa-Hibi, Hirokazu Hirai, Taku Nagai, Kiyofumi Yamada, Akio Tsuboi

    Cell Reports   Vol. 8   page: 1-15   2014.8

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  70. Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies. Reviewed

    Akira Nakajima, Yasushi Ohizumi, Kiyofumi Yamada

    Clinical Psychopharmacology and Neuroscience   Vol. 12 ( 2 ) page: 75-82   2014.8

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  71. Alterations of GABAergic and domainergic system in mutant mice with disruption of exons 2 and 3 of the Disc1 gene. Reviewed

    Nakai T, Nagai T, Wang R, Yamada S, Kuroda K, Kaibuchi K, Yamada K

    Neurochem. Int.   Vol. 74   page: 74-83   2014.7

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  72. Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor. Reviewed

    Yuki Aoyama, Akihiro Mouri, Kazuya Toriumi, Takenao Koseki, Shiho Narusawa, Natsumi Ikawa, Takayoshi Mamiya, Taku Nagai, Kiyofumi Yamada, Toshitaka Nabeshima

    International Journal of Neuropsychopharmacology   Vol. 17 ( 5 ) page: 723-737   2014.5

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  73. Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes. Reviewed

    Shinnnosuke Yamada, Taku Nagai, Tsuyoshi Nakai, Daisuke Ibi, Akira Nakajima, Kiyofumi Yamada

    Brain,Behavior, and Immunity   Vol. 38   page: 272-282   2014.5

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  74. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Reviewed

    Yukio Mano, Tomomi Kotani, Mikako Ito, Taku Nagai, Yuko Ichinohashi, Kiyofumi Yamada, Kinji Ohno, Fumitaka Kikkawa, Shinya Toyokuni.

    Free Radical Biology and Medicine   Vol. 69   page: 324-330   2014.4

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  75. Alteration of gene expression and DNA methylation in drug-resistant gastric cancer. Reviewed

    Maeda O, Ando T, Ohmiya N, Isiguro K, Watanabe O, Miyahara R, Hibi Y, Nagai T, Yamada K

    Oncol Rep   Vol. 31   page: 1883-1890   2014.4

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  76. Deletion of SHATI/NAT8L increases dopamineD1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Reviewed

    Kazuya Toriumi, Mizuki Kondo, Taku Nagai, Ryota Hashimoto, Kazutaka Ohi, Ziyu Song,Junko Tanaka, Akihiro Mouri, Takenao Koseki, Hidenaga Yamamori, Yoko Furukawa-Hibi, Takayoshi Mamiya, Takeshi Fukushima, Masatoshi Takeda, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima.

    International Journal of Neuropsychopharmacology   Vol. 17 ( 3 ) page: 443-53   2014.3

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  77. Combination of neonatal Polyl:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Reviewed

    Hirotake Hida,Akihiro Mouri,Yu Ando,Kentaro Mori,Takayoshi Mamiya,Kunihiro Iwamoto,Norio Ozaki,Kiyofumi Yamada,Toshitaka Nabeshima,Yukihiro Noda.

    Behavioural Brain Research.   Vol. 258   page: 34-42   2014.1

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  78. Evalution of cognitive behaviors in young offspring of C57BL/6J mice after gestational nicotine exposure during different time-windows

    Tursun Alkam, Hyoung-Chun Kim, Takayoshi Mamiya, Kiyofumi Yamada, Masayuki Hiramatsu, Toshitaka Nabeshima

    Psychopharmacology   Vol. 230 ( 3 ) page: 451-463   2013.12

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  79. Role of Matrix Metalloproteinases and Their in Epileptogenesis and Seizures.

    Hiroyuki Mizoguchi,Kiyofumi Yamada.

    Clinical Psychopharmacology and Neuroscience.   Vol. 11 ( 2 ) page: 45-52   2013.8

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  80. Role of convergent activation of glutamatergic and dopaminergic systems in the nucleus accumbens in the development of methamphetamine psychosis and dependence.

    Masayuki Miyazaki,Yukihiro Noda,Akihiro Mouri,Kazuto Kobayashi,Masayoshi Mishima,Toshitaka Nabeshima,Kiyofumi Yamada.

    Int J Neuropsychopharmacol.   Vol. 16 ( 6 ) page: 1341-1350   2013.7

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  81. Correlation of CYP2C19 Phenotype With Voriconazole Plasma Concentration in Children

    Atsushi Narita, Hideki Muramatsu, Hirotoshi Sakaguchi, Sayoko Doisaki, Makito Tanaka, Asahito Hama, Akira Shimada, Yoshiyuki Takahashi, NaoYoshida, Kimikazu Matsumoto, Koji Kato, Kazuko Kudo, Yoko Furukawa-Hibi, Kiyofumi Yamada, Seiji Kojima

    J Pediatr Hematol Oncol   Vol. 35 ( 5 ) page: 219-223   2013.7

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  82. Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules.

    Akihiro Mouri,Taku Nagai,Daisuke Ibi,Kiyofumi Yamada.

    Neurobiol Dis.   Vol. 53   page: 61-74   2013.5

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  83. Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.

    Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K

    Glia   Vol. 61   page: 679-693   2013.5

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  84. Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in sic different time-windows.

    Alkam T,Kim HC,Hiramatsu M,Mamiya T,Aoyama Y,Nitta A,Yamada K,Nabeshima T.

    Behav Brain Res.   Vol. 239   page: 80-89   2013.2

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  85. Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and reapse in mice.

    Yan Y,Miyamoto Y,Nitta A,Muramatsu SI,Ozawa K,Yamada K,Nabeshima T.

    Int J Neuropsychopharmacol.   Vol. 22   page: 1-9   2013.2

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  86. Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats.

    Zhang L,Nagai T,Yamada K,Ibi D,Ichihara S,Subramanian K,Huang Z,Mohideen SS,Naito H,Ichihara G.

    Toxicology   Vol. 304   page: 76-82   2013.2

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  87. Neuronal PAS domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I.

    Jaesuk Yun,Taku Nagai,Yoko Furukawa-Hibi,Keisuke Kuroda ,Kozo Kaibuchi,Michael E.Greenberg,Kiyofumi Yamada.

    J Bio Chem.   Vol. 288 ( 4 ) page: 2655-64   2013.1

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  88. SHATI/NAT8L Regulates Neurite Outgrowth Via Microtubule Stabilization.

    Kazuya Toriumi,Miki Ikami,Mizuki Kondo,Akihiro Mouri,Takenao Koseki,Daisuke Ibi,Yoko Furukawa-Hibi,Taku Nagai,Takayoshi Mamiya,Atsumi Nitta,Kiyofumi Yamada,Toshitaka Nabeshima.

    Journal of Neuroscience Research91.     page: 1525-1532   2013

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  89. The risk factors of severe acute kidney injury induced by cisplatin.

    Mizuno T, Ishikawa K, Sato W, Koike T, Kushida M, Miyagawa Y, Yamada K, Hirata S, Imai E, Noda Y

    Oncology   Vol. 85   page: 364-369   2013

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  90. Transcriptional suppression of the neuronal PAS domain 4(Npas 4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter.

    Furukawa-Hibi Y,Yun J,Nagai T,Yamada K,

    J Neurochem.   Vol. 123 ( 5 ) page: 866-875   2012.12

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  91. Reliability and Validity of the Japanese Version of BEMIB Modified for Patients With Bipolar Disorder: a Self-rating Scale for Medication Adherence.

    Tokura T,Kimura H,Yoshimi A,Ohashi M,Masuda M,Senzaki K,Yoshida K,Aleksic B,Noda Y,Yamada K,Ozaki N.

    CNPT(Clinical Neuropsychopharmacology and Therapeutics.     page: 26-32   2012.12

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  92. D-serine ameliorates neonatal poly I:C treatment-induced emotional and cognitive impairments in adult mice.

    Nagai T,Yu J,Kitahara Y,Nabeshima T,Yamada K.

    Neuropharmacology   Vol. 120 ( 3 ) page: 213-227   2012.11

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  93. Dopamine release via the vacuolar ATPase V0 sector c-subunit,confirmed in N18 neuroblastoma cells,results in behavioral recovery in hemiparkinsonian mice.

    Jin D,Muramatsu S,Shimizu N,Yokoyama S,Hirai H,Yamada K,Liu HX,Higashida C,Hashii M,Higasida A,Asano M,Ohkuma S,Higasida H.

    Neurochem Int.   Vol. 61 ( 6 ) page: 907-12   2012.11

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  94. Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomy in elderly patients.

    Mizuno T, Ito K, Miyagawa Y, Ishikawa K, Suzuki Y, Mizuno M, Ito Y, Funahashi Y, Hattori R, Gotoh M, Yamada K, Noda Y

    Jpn J Clin Oncol.   Vol. 42   page: 1073-1078   2012.11

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  95. Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomaized mice.

    Takuma K, Mizoguchi H, Funatsu Y, Kitahara Y, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T, Yamada K

    J. Pharmacol. Sci.   Vol. 120   page: 89-97   2012.10

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  96. Absence of SHATI/Nata81 reduces social interaction in mice.

    Yoko Furukawa-Hibi,Atsumi Nitta,Hidefumi Fukumitsu,Hitomi Somiya,Kazuya Toriumi,Shoei Furukawa,Toshitaka Nabeshima,Kiyofumi Yamada.

    Neuroscience Lettters   Vol. 526 ( 2 ) page: 79-84   2012.9

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  97. Pharmacist-based Donepezil Outpationt Consultation Service to improve medication persistence.

    Watanabe N,Yamamura K,Suzuki Y,Umegaki H,Shigeno K,Matsushita R,Sai Y,Miyamoto K,Yamada K.

    Patient Prefer Adherence.   Vol. 6   page: 605-11   2012.9

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  98. Repeated tretment with nicotine induced phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization.

    Nakajima A,Kinupasa Y,Torii J,Hishinuma T,Tomioka Y,Yamada K,Yamakuni T.

    Neurosci Lett.   Vol. 524 ( 2 ) page: 133-138   2012.8

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  99. Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia.

    Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Esaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S.

    Blood.   Vol. 120   page: 1485-1488   2012.8

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  100. Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice.

    Yan Y,Nitta A,Koseki T,Yamada K,Nabeshipa T

    Psychopharmacology(Berl.)   Vol. 221 ( 3 ) page: 427-36   2012.6

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  101. Effect of shingle therapeutic doses of promethzine,fexofenadine and olopatadine on psychomotor function and histamine-induced wheal-and flare-responses:a randomized double-blind,placebo-controlled study in healthy volunteers.

    Kamei H,Isaji A,NodaY,Ishikawa K,Senzaki K,Yamada K,Tomita Y,Nabeshima T

    Arch Dematol Res   Vol. 304 ( 4 ) page: 263-72   2012.5

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  102. Involvement of matrix metalloproteinases-9 in the development of morphine tolerance.

    Nakamoto K,Kawasaki S,Kobori T,Fujita-Hamabe W,Mizoguchi H,Yamada K,Nabeshima T,Tokuyama S.

    Eur J Pharmacol.   Vol. 683 ( 1-3 ) page: 86-92   2012.5

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  103. Nobiletin,a citrus flavonoid,ameliorates cognitive impairment,oxidative burden,and hyperphosphorylation of tau in senescence-accelerated mouse.

    Akira Nakajima,Yuki Aoyama,Thuy-Ty Lan Nguyen,Eun Joo Shin,Hyoung-Chun Kim,Shinnosuke Yamada,Tsuyoshi Nakai,Taku Nagai,Akihiro Yokosuka,Yoshihiro Mimaki,Yasushi Ohizumi,Kiyofumi Yamada.

    Behavioural Brain Research Pii.   Vol. S0166-4328 ( 13 ) page: 00304-5   2012.5

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  104. Protective potentioal of IL-6 against trimethyltin-induced neurotoxicity in vivo.

    Tran HY,Shin EJ,Saito K,Nquyen XK,Chung YH,Jeong JH,Park DH,Yamada K,Nabeshima T,Yoneda Y,Kim HC

    Free Radic.Bio.Med.   Vol. 52 ( 7 ) page: 1159-1174   2012.4

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  105. Combination of Chronic Stress and Ovariectomy Causes Conditioned Fear Memory Deficites and Hippocampal Cholinergic Neuronal Loss in Mice

    Takuma K,Mizoguchi H,Funatsu Y,Hoshina Y,Himeno Y,Fukuzaki E,Kitahara Y,Arai S,Ib D,Kamei H,Matsuda K,Koike K,Inoue M,Nagai T,Yamada K.

    Neuroscience   Vol. 207   page: 261-73   2012.4

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  106. MEGA-D1 Regulates Expression of Depression-Like Behavior through Serotonin Transporter Ubiquitylation.

    Mouri A,Sasaki A,Watanabe K,Sogawa C,Kitayama S, Mamiya T,Miyamoto Y,Yamada K,Noda Y,Nabeshima T.

    J Neurosci.   Vol. 32 ( 13 ) page: 0   2012.3

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  107. Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome

    Iriyama C,Tomita A,Hoshino H,Adachi-Shirahata M,Furukawa-Hibi Y,Yamada K,Kiyoi H, Naoe T.

    Biophys Res Commun.   Vol. 419 ( 4 ) page: 662-9   2012.3

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  108. Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model.

    Kato H, Mizuno T, Mizuno M, Sawai A, Suzuki Y, Kinashi H, Nagura F, Maruyama S, Noda Y, Yamada K, Matsuo S, Ito Y.

    Nephrol. Dial. Transplant.   Vol. 27   page: 526-536   2012.2

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  109. Renal impairment after laparoscopic radical nephrectomy affects hypoglycaemic therapy.

    Mizuno T, Ito K, Miyagawa Y, Kimura K, Suzuki Y, Mizuno M, Ito Y, Funahasi Y, Hattori R, Gotoh M, Noda Y, Yamada K

    J Clinic. Pharm. Therapeu.   Vol. 37   page: 49-52   2012.2

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  110. KDIGO criteria could be useful outcome predictor of cisplatin-induced acute kidney injury.

    Mizuno T,Sato W,Ishikawa K,Shinjo H,Miyagawa Y,Noda Y,Imai E,Yamada K.

    Oncology   Vol. 82 ( 6 ) page: 354-359   2012

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  111. Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines.

    Nawa H, Yamada K

    Psychiatric Disorders: Methods and Protocols.     2012

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    DOI: 10.1007/978-1-61779-458-2_28

  112. Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy.

    Mizoguchi H, Yamada K, Nabeshima T

    Biochem. Res. Internat.     2011.12

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    DOI: 10.1155/2011/681385

  113. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the DISC1 gene in the mouse.

    Kuroda K, Yamada S, Tanaka, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K, Kaibuchi K

    Hum. Mol. Genet.   Vol. 20   page: 4666-4683   2011.12

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  114. Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-beta peptide in mice.

    Furukawa-Hibi Y, Alkam T, Nitta A, Matsuyama A, Mizoguchi H, Suzuki K, Moussaoui S, Yu Q-S, Greig NH, Nagai T, Yamada K

    Behav Brain Res.   Vol. 225   page: 222-229   2011.11

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  115. Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment.

    Nagai T, Kitahara Y, Ibi D, Nabeshima T, Sawa A, Yamada K

    Behav. Brain Res.   Vol. 225   page: 305-310   2011.11

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  116. Animal Model For Schizophrenia That Reflects Gene-Environment Interactions.

    Taku Nagai, Daisuke Ibi and Kiyofumi Yamada

    Biological & Pharmaceutical Bulletin   Vol. 34 ( 9 ) page: 1364-1368   2011.9

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  117. Translational research in neurodevelopmental disorders: Development of etiology-based animal models foreword.

    Yamada K

    Biol. Pharm. Bull.   Vol. 34   page: 1357   2011.9

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  118. Relationship between hematotoxicity and serum albumin level in the Treatment of head and neck cancers with concurrent chemoradiotherapy using cisplatin.

    Ishizuka M, Fujimoto Y, Itoh Y, Sano M, Miyagawa Y, Ando A, Hiramatsu M, Hirasawa N, Ishihara S, Nabeshima T, Yamada K.

    Jpn. J. Clin. Oncol.   Vol. 41   page: 973-979   2011.8

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  119. Nicotine ameliorates impairment of working memory in methamphetamine-treated rats.

    Mizoguchi H, Ibi D, Takase F, Nagai T, Kamei H, Toth E, Sato J, Takuma K, Yamada K

    Behav Brain Res.   Vol. 220 ( 1 ) page: 159-163   2011.7

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  120. Matrix metalloproteinase-9 contributes to kindlined seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.

    Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K

    J Neurosci   Vol. 31   page: 12963-12971   2011.7

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  121. The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF.

    Furukawa-Hibi Y, Nitta A, Ikeda T, Morishita K, Liu W, Ibi D, Alkam T, Nabeshima T, Yamada K

    Behav Brain Res.   Vol. 220   page: 271-280   2011.7

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  122. Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage.

    Shichi K,Fujita-Hamane W,Harada S,Mizoguchi H,Yamada K,Nabeshima T,Tokuyama S

    J Pharmacol ExpTher.   Vol. 332 ( 2 ) page: 701-10   2011.5

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  123. Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy.

    Wakasaya Y,Kawarabayashi T,Watanabe M,Yamamoto-Watanabe Y,Takamura A,Kurata T,MurakamiT,Abe K,Yamada K,Wakabayashi K,Sasaki A,Westaway D,Hyslop PS,Matsubara E,Shoji M.

    J Neurosci Res.   Vol. 89 ( 4 ) page: 576-84   2011.4

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  124. Effects of Gastrodia Bl on Phencycline-Induced Schizophrenia-Like psychosis in Mice.

    E-J. Shin, J-M. Kim, X-K T Nguyen, T-T L Nguyen, S Y Lee, J-H Jung, M J Kim, W K Whang, K Yamada, T Nabeshima and H-C Kim

    Current Neuropharmacology   Vol. 9   page: 245-250   2011.3

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  125. Pharmacologic treatment with GABA(B) receptor agonist on methamphetamine-induced cognitive impairment in mice.

    Mizoguchi H, Yamada K

    Curr. Neuropharmacol.   Vol. 9   page: 109-112   2011.3

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  126. Evaluation of object-based attention in mice. Reviewed

    Alkam T, Hiramatsu M, Mamiy T, Aoyama A, Nitta A, Yamada K, Kim HC, Nabeshima T

    Behav Brain Res.   Vol. 220 ( 1 ) page: 185-193   2011.1

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  127. Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation. Reviewed

    Mizuno T, Mizuno M, Morgan BP, Noda Y, Yamada K, Okada N, Yuzawa Y, Matsuo S, Ito Y

    Nephrol Dial Transplant   Vol. 26 ( 6 ) page: 1821-1830   2011.1

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  128. Matrix metalloproteinase-9 contributes to kindlined seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.

    Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K

    J Neurosci.   Vol. 31   page: 12963-12971   2011

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  129. Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty. Reviewed

    Miyagawa Y, Ejiri M, Kuzuya T, Osada T, Ishiguro N and Yamada K

    J. Clin. Pharm. Ther.   Vol. 35 ( 6 ) page: 679-684   2010.12

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  130. Overexpression of piccolo C2A domain induces depression-like behavior in mice. Reviewed

    Furukawa-Hibi Y, Nitta A, Fukumitsu Y, Somiya H, Furukawa S, Nabeshima T, and Yamada K

    Neuroreport   Vol. 21 ( 18 ) page: 1177-1181   2010.12

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  131. Gene-wide association study between methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population with an updated meta-analysis on currently available data.

    Yoshimi A, Aleksic B, Kawamura Y, Takahashi N, Yamada S, Usui H, Saito S, Ito Y, Iwata N, Inada T, Noda Y, Yamada K, Ozaki N

    Schizophr. Res.   Vol. 124   page: 216-222   2010.12

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  132. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems.

    Noda Y, Mouri A, Ando Y, Waki Y, Yamada SN, Yoshimi A, Yamada K, Ozaki N, Wang D, Nabeshima T

    Int J Neuropsychopharmacol.   Vol. 11   page: 1-12   2010.11

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  133. Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4.

    Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, Yoneyama M, Ogita K, Yoneda Y, Nabeshima T, Nagai T, Yamada K

    J. Neurochem   Vol. 114 ( 6 ) page: 1840-1851   2010.9

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  134. Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase.

    Alkam T, Nitta A, Furukawa-Hibi Y, Niwa M, Mizoguchi H, Yamada K, Nabeshima T

    Behav Brain Res.   Vol. 210 ( 2 ) page: 184-190   2010.7

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  135. Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT(1A) Receptor.

    Shin EJ, Whang WK, Kim S, Bach JH, Kim JM, Nguyen XK, Nguyen TT, Jung BD, Yamada K, Nabeshima T, Kim HC

    J. Pharmacol Sci.   Vol. 113 ( 4 ) page: 404-408   2010.7

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  136. Cytokine Receptor-Like Factor 1 is Highly Expressed in Damaged Human Knee Osteoarthritic Cartilage and Involved in Osteoarthritis Downstream of TGF-beta.

    Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, Hara T, Ishibashi H, Koshihara Y, Yamada K, Yoneda Y:

    Calcified Tissue Int.   Vol. 86   page: 47-57   2010.6

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  137. Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Reviewed

    Ohki M, Ohki Y, Akiyama H, Ishihara M, Nishida C, Komiyama H, Lund LR, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Werb Z, Heissig B, Hattori K

    Blood.   Vol. 115 ( 21 ) page: 4302-4312   2010.5

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  138. Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy.

    Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G

    J Neurosci.   Vol. 30 ( 16 ) page: 5702-5712   2010.4

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  139. Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment.

    Lu P, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, Zou L B, Nagai T, Yamada K, Ikejima T, Nabeshima T

    Behav Brain Res.   Vol. 207 ( 2 ) page: 387-393   2010.3

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  140. Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: An in vivo microdialysis study.

    Nagai T, Kitahara Y, Shiraki A, Hikita T, Taya S, Kaibuchi K, Yamada K

    Neurosci.Lett   Vol. 470 ( 2 ) page: 134-138   2010.2

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  141. Cytokine receptor-like factor 1 is highly expressed in damaged human knee OA cartilage and is involved in OA downstream of TGF-β.

    Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, Toshifumi Hara T, Ishibashi H, Koshihara Y, Yamada K, Yoneda Y

    Calcif Tissue Int.   Vol. 86 ( 1 ) page: 47-57   2010.1

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  142. Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Reviewed

    Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, and Yamada K

    Behav. Brain Res.   Vol. 206 ( 1 ) page: 32-37   2010.1

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  143. Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice.

    Mizoguchi H, Ibi D, Takuma K, Toth E, Sato J, Itohara S, Nabeshima N, Yamada K

    The Open Behavioral Science Journal.   Vol. 4   page: 19-25   2010

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  144. Nicotine ameliorates emotional and cognitive impairments induced by neonatal polyI:C treatment in mice.

    Yu J, Nagai T, Ibi D, Kitahara Y, Nabeshima T, Yamada K

    The Open Behavioral Science Journal.   Vol. 4   page: 9-18   2010

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  145. A survey of antipsychotic polypharmacy in outpatients at Nagoya University Hospital. Reviewed

    Yoshimi A, Noda Y, Aleksic B, Senzaki K, Ohashi M, Yamada S, Yamada K and Ozaki N

    Clinical Neuropsychopharmacology and Therapeutics     page: 43-49   2010

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  146. Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons. Reviewed

    Mizoguchi H, Arai S, Koike H, Ibi D, Kamei H, Nabeshima T, Kim HC, Takuma K ,Yamada K.

    Psychopharmacology   Vol. 207 ( 2 ) page: 235-243,   2009.12

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  147. Role of microsomal epoxide hydrolase in methamphetamine-induced drug dependence in mice Reviewed

    Shin EJ, Bing G, Chae JS, Kim TW, Bach JH, Park DH, Yamada K, Nabesima T, Kim HC

    J Neurosci Res.   Vol. 87 ( 16 ) page: 3679-86.   2009.12

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  148. Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairment. Reviewed

    Jin CH, Shin EJ, Park JB, Jang CG, Li Z, Kim MS, Koo KH, Yoon HJ, Park SJ, Choi WC, Yamada K, Nabeshima T and Kim HC

    J. Neurosci. Res.   Vol. 87 ( 16 ) page: 3658-70.   2009.12

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  149. *RAGE-mdiated signaling contributes to intraneuronal transport of amyloid- and neuronal dysfunction. Reviewed

    Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K and Yan SD

    Proc Natl Acad Sci USA   Vol. 106 ( 47 ) page: 20021-20026   2009.11

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  150. An environmental and biological study of occupational exposure to cyclophosphamide in the pharmacy of a Japanese community hospital designated for the treatment of cancer. Reviewed

    Tanimura M, Mori K, Nagata H, Tadokoro K, Miyake T, Hamaguchi Y, Sessink PJM, Sugiura S, Yamada K and Nabeshima T

    J. Health Sci.   Vol. 55 ( 5 ) page: 750   2009.10

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  151. Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice. Reviewed

    Shin EJ, Jang CG, Bing G, Park DH, Oh CH, Koo KH, Oh KW, Yamada K, Nabeshima T and Kim HC

    Drug Alcohol Dependence.   Vol. 104 ( 1-2 ) page: 175-84.   2009.9

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  152. Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic condition. Reviewed

    Otsuka N, Tsuritani K, Sakurai T, Kato K, Matoba R, Itoh J, Okuyama S, Yamada K and Yoneda Y

    Brain Res   Vol. 1287 ( 136-145 )   2009.9

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  153. Population pharmacokinetic analysis of vancomycin in patients with gram-positive infections and the influence of infectious disease type. Reviewed

    Yamamoto M, Kuzuya T, Baba H, Yamada K and Nabeshima T

    J. Clin. Pharm. Ther.   Vol. 34 ( 4 ) page: 473-83.   2009.8

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  154. Behavioral abnormality and phamacologic response in social isolation-reared mice. Reviewed

    Koike H, Ibi D, Mizoguchi H, Nagai T, Nitta A, Takuma K, Nabeshima T, Yoneda Y, Yamada K.

    Behav. Brain Res.   Vol. 202   page: 114–121   2009.8

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  155. Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood. Reviewed

    Ibi D, Nagai T, Kitahara Y, Mizoguchi H, Koike H, Shiraki A, Takuma K, Kamei H, Noda N, Nitta A, Nabeshima T, Yoneda Y and Yamada K

    Neurosci. Res.   Vol. 64   page: 297-305   2009.7

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  156. The latent risk of acidosis in commercially available total parenteral nutrition (TPN)products: a randomized clinical trial in postoperarative patients Reviewed

    Katsuyoshi Kato, Shin-ichi Sugiura, Kohji Yano, Toshio Fukuoka, Akio Itoh, Masato Nagino, Toshitaka Nabeshima, Kiyofumi Yamada.

    J.Clin.Biochem.Nutr.   Vol. 45 ( 68-73 )   2009.7

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  157. Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly. Reviewed

    168 Gu B, Nakamichi N, Zhang WS, Nakamura Y, Kambe Y, Fukumori R, Takuma K, Yamada K, Takarada T, Taniura H and Yoneda Y

    J. Neurosci. Res.   Vol. 87 ( 2145-2156 )   2009.7

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  158. Matrix metalloprotease-9 inhibition improves amyloid b-mediated cognitive impairment and neurotoxicity in mice. Reviewed

    Mizoguchi H, Takuma K, Fukuzaki E, Ibi D, Someya E, Akazawa K, Alkam T, Tsunekawa H, Mouri A, Noda Y, Nabeshima T and Yamada K

    J. Pharmacol. Exp. Ther.   Vol. 331   page: 14-22   2009.7

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  159. The chondroprotective agent ITZ-1 inhibits interleukin-1β-induzced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death Reviewed

    Kimura H, Yukitake H, Suzuki H, Tajima Y, Gomaibashi K, Morimoto S, Funabashi Y, Yamada K, Takizawa M

    J. Pharmacol. Sci.   Vol. 110 ( 201-211 )   2009.6

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  160. Antiamnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid β25-35 -induced toxicity in mice. Reviewed

    Villard V, Espallergues J, Keller E, Alkam T, Nitta A, Yamada K, Nabeshima, T, Vamvakides A and Maurice T

    Neuropsychopharmacology   Vol. 34   page: 1552-1566   2009.5

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  161. Evaluation of interleukin-2 mRNA in whole blood as a parameter for monitoring cyclosporine pharmacodynamics. Reviewed

    Kuzuya T, Kobayashi T, Katayama A, Nagasaka T, Miwa Y, Uchida K, Nakao A and Yamada K

    Biol. Pharm. Bull.   ( 32 ) page: 604-608   2009.4

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  162. Pharmacodynamicsを用いた代謝拮抗薬およびmTOR阻害薬の薬効評価 Reviewed

    水野加代子,葛谷孝文,加藤真梨奈,倉田洋子,岩崎研太, 野田幸裕,網岡克雄,山田清文,小林孝彰

    愛知県病院薬剤師会雑誌   Vol. 36 ( 4 )   2009.4

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  163. 痛みの表現に基づく痛みの評価 ―肺がん患者における痛みの表現と原因との関連性の検討―. Reviewed

    稲垣聡美、宮崎雅之、加藤勝義、手塚智子、長谷川好規、鍋島俊隆、野田幸裕、山田清文

    日本緩和医療薬学雑誌     page: 65-73   2009.2

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  164. 外来喘息教室における薬剤師の役割とその効果について Reviewed

    倉田洋子,岸里奈,山田真之亮,長谷川雅哉,山田清文,久米裕昭,長谷川好規,鍋島俊隆,野田幸裕

    医療薬学   Vol. 35   page: 145-151   2009.2

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  165. GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice. Reviewed

    Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Kamei H, Kim HC and Yamada K

    Eur. J. Pharmacol.   Vol. 602   page: 101-104   2009.1

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  166. Growth hormone–releaser diet attenuates β-amyloid(1-42)–induced cognitive impairment via stimulation of the insulin-like growth factor (IGF)-1 receptor in mice. Reviewed

    Shin EJ, Chae JS, Park SJ, Kim SC, Koo KH, Yamada K, Nabeshima T and Kim HC:

    J. Pharmacol. Sci.   ( 109 ) page: 139-143   2009.1

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  167. ドーパミン神経系と意思決定:薬物依存者における機能障害. Reviewed

    山田清文

    臨床精神医学   Vol. 38   page: 印刷中   2009

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  168. Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice. Reviewed

    Mizoguchi H, Takuma K, Fukakusa A, Ito Y, Nakatani A, Ibi D, Kim HC and Yamada K

    Psychopharmacology   Vol. 196   page: 233-241   2008

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  169. Restraining tumor necrosis factor-alpha by thalidomide prevents the Abeta-induced impairment of recognition memory in mice. Reviewed

    Alkam T, Nitta A, Mizoguchi H, Saito K, Seshima M, Itoh A, Yamada K and Nabeshima T

    Behav. Brain Res.   Vol. 189   page: 100-106   2008

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  170. Documenting the value of a pharmacist-managed anticoagulation classroom. Reviewed

    Yano K, Yamamura K, Osada T, Fukase F, Kiriyama N, Torimoto M, Yamada K, Kishi DT and Nabeshima T

    J. Appl. Ther. Res.   Vol. 6   page: 41-48   2008

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  171. Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens. Reviewed

    Fukakusa A, Nagai T, Mizoguchi H, Otsuka N, Kimura H, Kamei H, Kim H-C, Nabeshima T, Takuma K and Yamada K

    J. Neurochem.   Vol. 105   page: 436-444   2008

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  172. 造影剤使用による腎機能障害~造影剤腎症~. Reviewed

    水谷佳代, 加藤博史, 山田清文, 野田幸裕, 鍋島俊隆

    愛知県病院薬剤師会雑誌   Vol. 36 ( 1 ) page: 2-6   2008

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  173. 成人の喘息‐薬剤師によるファーマシューティカルケア外来. Reviewed

    長谷川雅哉, 鍋島俊隆, 山田清文

    薬事   Vol. 50   page: 389-393   2008

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  174. 米国ノースカロライナ大学における臨床薬学教育. Reviewed

    石塚雅子,山田清文,鍋島俊隆

    日本病院薬剤師会雑誌   Vol. 44   page: 297-302   2008

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  175. 薬物依存に関与するサイトカイン・プロテアーゼの動態および機能解析. Reviewed

    山田清文

    日本神経精神薬理学雑誌   Vol. 28   page: 195-201   2008

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  176. 組織プラスミノーゲン活性化因子による依存性薬物の報酬効果の制御. Reviewed

    永井拓,田熊一敞,鍋島俊隆,山田清文

    日本神経精神薬理学雑誌   Vol. 28   page: 1-6   2008

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  177. ニコチン依存における組織プラスミノーゲン活性化因子の役割.

    永井拓,山田清文

    日本アルコール・薬物医学会雑誌   Vol. 43   page: 151-157   2008

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  178. 抗真菌薬と免疫抑制薬‐併用における留意点.

    太田小織, 山田清文

    深在性真菌症~SFI Forum~   Vol. 4   page: 25-27   2008

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  179. 婦人科がん化学療法による嘔気・嘔吐の改善に向けたプロトコールの見直し. Reviewed

    川村由季子, 手塚智子, 桐山典子, 石川和宏, 山田清文, 鍋島俊隆, 野田幸裕

    医薬ジャーナル   Vol. 44   page: 2435-2440   2008

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  180. Basic and translational research on proteinase-activated receptors: Regulation of nicotine reward by the tissue plasminogen activator (tPA) – plasmin system via proteinase-activated receptor 1. Reviewed

    Nagai T, Nabeshima T and Yamada K

    J. Pharmacol. Sci.   Vol. 108   page: 408-414   2008

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  181. Role for anti-addictive and pro-addictive factor in drug dependence. Invited Reviewed

    Yamada K

    Nagoya J. Med. Sci.   Vol. 70   page: 67-72   2008

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  182. Neuropsychotoxicity of Abused Drugs: Involvement of matrix metalloproteinase-2 and -9, and tissue inhibitor of matrix metalloproteinase-2 in methamphetamine-induced behavioral sensitization and reward in rodents. Reviewed

    Mizoguchi H, Yamada K and Nabeshima T

    J. Pharmacol. Sci.   Vol. 106   page: 9-14   2008

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  183. Neuropsychotoxicity of abused drugs: Clinical and basic research and drug development: Preface. Reviewed

    Yamada K and Kaneko S

    J. Pharmacol. Sci.   Vol. 106   page: 1   2008

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  184. Endogenous modulators for drug dependence. Reviewed

    Yamada K

    Biol. Pharm. Bull.   Vol. 31   page: 1635-1638   2008

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  185. ステロイド剤が導入された婦人科がん化学療法レジメンの評価. Reviewed

    桐山典子,手塚智子,川村由季子,石川和宏,野田幸裕,鍋島俊隆,山田清文

    日本緩和医療薬学雑誌   Vol. 1   page: 47-52   2008

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  186. Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload. Reviewed

    Kanazawa Y, Makino M, Morishima Y, Yamada K, Nabeshima T and Shirasaki Y

    Neuroscience   Vol. 154   page: 473-481   2008

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  187. Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits. Reviewed

    Fukuzaki E, Takuma K, Himeno Y, Yoshida S, Funatsu Y, Kitahara Y, Mizoguchi H, Ibi D, Koike K, Inoue M and Yamada K

    Neurosci. Lett.   Vol. 433   page: 141-145   2008

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  188. Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen. Reviewed

    Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Takahashi K, Kamei H, Nabeshima T and Yamada K

    Neuropsychopharmacology   Vol. 33   page: 3164-3175   2008

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  189. Ovariectomy increases neuronal amyloid β binding alchohol dehydrogenease level in the mouse hippocampus. Reviewed

    Fukuzaki E, Takuma K, Funatsu Y, Himeno Y, Kitahara Y, Gu B, Mizoguchi H, Ibi D, Koike K, Inoue M, Yan SD and Yamada K

    Neurochem. Int.   Vol. 52   page: 1358-1364   2008

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  190. Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. Reviewed

    Fukakusa A, Mizoguchi H, Koike H, Nabeshima T, Takuma K and Yamada K

    J. Pharmacol. Sci.   Vol. 106   page: 321-324   2008

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  191. The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid β in mice. Reviewed

    Alkam T, Nitta A, Mizoguchi H, Itoh A, Murai R, Nagai T, Yamada K and Nabeshima T

    J. Pharmacol. Exp. Ther.   Vol. 27   page: 137-147   2008

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  192. Production and functions of IL-17 in microglia. Reviewed

    Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H and Suzumura A

    J. Neuroimmunol.   Vol. 194   page: 54-61   2008

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  193. A novel molecule `shati' increases dopamine uptake via the induction of tumor necrosis factor-α in pheochromocytoma-12 cells. Reviewed

    Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K and Nabeshima T

    J. Neurochem.   Vol. 107   page: 1697-1708   2008

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  194. Tamaki K, Yamada K, Nakamichi N, Taniura H and Yoneda Y Reviewed

    Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience.

    J. Neurochem.   Vol. 105   page: 1642-1655   2008

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  195. Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. Reviewed

    Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, Kamei H, Nagai T, Yoneda Y, Nabeshima T and Yamada K

    J. Neurochem.   Vol. 105   page: 921-932   2008

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  196. Transient drug-primed but persistent cue-induced reinstatement of extinguished methamphetamine-seeking behavior in mice. Reviewed

    Yan Y, Yamada K, Nitta A and Nabeshima T

    Behav. Brain Res.   Vol. 177   page: 261-268   2007

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  197. Repeated methamphetamine impairs spatial working memory in rats: reverasal by clozapine but not haloperidol. Reviewed

    Nagai T, Takuma K, Dohniwa M, Ibi D, Mizoguchi H, Kamei H, Nabeshima T and Yamada K

    Psychopharmacology   Vol. 194   page: 21-32   2007

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  198. Ginkgo bioba extract EGb761 improve hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats. Reviewed

    Takuma K, Hoshina, Y, Himeno Y, Arai S, Matsuo, A, Funatsu Y, Ibi, D, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K

    Neuroscience   Vol. 149   page: 256-262   2007

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  199. Reinforceing effects of morhine are reduced in tissue plasminogen activator (tPA)-knockout mice. Reviewed

    Yan Y, Yamada K, Mizoguchi H, Noda Y, Nagai T, Nitta A and Nabeshima T

    Neuroscience   Vol. 146   page: 50-59   2007

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  200. Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-OHDA-induced hemi-Parkinsonian mouse model. Reviewed

    Matsuya T, Takuma K, Sato K, Asai M, Murakami Y, Miyoshi S, Noda A, Nagai T, Mizoguchi H, Nishimura S and Yamada K

    J. Pharmacol. Sci.   Vol. 103   page: 329-332   2007

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  201. Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine. Reviewed

    Maeda K, Sugino H, Hirose T, Kitagawa H, Nagai T, Mizoguchi H, Takuma K and Yamada K

    J. Pharmacol. Sci.   Vol. 103   page: 299-308   2007

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  202. Activation of postsynaptic dopamine D1 receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling. Reviewed

    Ito M, Nagai T, Mizoguchi H, Sato K, Hayase M, Otsuka N, Nabeshima T, Takuma K and Yamada K.

    J. Neurochem.   Vol. 103   page: 2589-2596   2007

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  203. Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9 deficient mice. Reviewed

    Mizoguchi H, Yamada K, Niwa M, Mouri A, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T

    J. Neurochem.   Vol. 100   page: 1579-1588   2007

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  204. Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue-plasminogen activator-plasmin system. Reviewed

    Ito M, Nagai T, Mizoguchi H, Fukakusa A, Nakanishi Y, Kamei H, Nabeshima T, Takuma K and Yamada K

    J. Neurochem.   Vol. 101   page: 1392-1399   2007

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  205. 放射状迷路を用いたDelayed spatial win-shift課題による空間作業記憶の評価(実験技術).

    永井拓、田熊一敞、亀井浩行、溝口博之、鍋島俊隆、山田清文

    日本薬理学雑誌   Vol. 129   page: 457-462   2007

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  206. Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. Reviewed

    Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T and Kim HC:

    J. Pharmacol. Sci.   Vol. 105   page: 367-371   2007

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  207. A dibenzoylmethane (DBM) derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum (ER) stress. Reviewed

    Takano K, Kitao Y, Tabata Y, Miura H, Sato K, Takuma K, Yamada K, Hibino S, Choshi T, Iinuma M, Suzuki H, Murakami R, Yamada M, Ogawa S and Hori O

    Am. J. Physiol. Cell Physiol.   Vol. 293   page: 1884-1894   2007

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  208. The roles of glia cell-derived neurotrophic factor, tumor necrosis factor-a, and an inducer of them in drug dependence.

    Niwa M, Nitta A, Yamada K and Nabeshima T

    J. Pharmacol. Sci.   Vol. 104   page: 116-121   2007

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  209. A novel azaindolizinone derivative ZSET1446, spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one, improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2. Reviewed

    Ito Y, Takuma K, Kamei Y, Mizoguchi H, Nagai T and Yamada K

    J. Pharmacol. Exp. Ther.   Vol. 320   page: 819-827   2007

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  210. Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: Implication for dopamine receptor downregulation and dopamine release. Reviewed

    Mizoguchi H, Yamada K, Mouri A, Niwa M, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T

    J. Neurochem.   Vol. 102   page: 1548-1560   2007

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  211. Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice. Reviewed

    Yan Y, Yamada K, Niwa M, Nagai T, Nitta A and Nabeshima T.

    FASEB J.   Vol. 21   page: 1994-2004   2007

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  212. 17b-Estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. Reviewed

    Takuma K, Matsuo A, Himeno Y, Hoshina Y, Ohno Y, Funatsu Y, Arai S, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K

    Neuroscience   Vol. 146   page: 60-68   2007

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  213. Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex. Reviewed

    Nagai T, Takuma K, Kamei H, Ito Y, Nakamichi N, Ibi D, Nakanishi Y, Murai M, Mizoguchi H, Nabeshima T and Yamada K

    Lean Mem.   Vol. 14   page: 117-125   2007

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  214. CD38 is critical for social behavior by regulating oxytocin secretion. Reviewed

    Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatia O, Shnayder NA, Yamada K, Noda M, Seike T, Tujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi M, Tanaka S, Hashi M, Yoshihara T, Hidashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M and Higashida H

    Nature   Vol. 446   page: 41-45   2007

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  215. Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice. Reviewed

    Takahashi K, Nagai T, Kamei H, Maeda K, Matsuya T, Arai S, Mizoguchi H, Yoneda Y, Nabeshima T, Takuma K and Yamada K

    Biol. Psychiatry   Vol. 62 ( 2 ) page: 148-157   2007

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  216. 学習・記憶行動の評価法. Reviewed

    田熊一敞,永井拓,山田清文

    日本薬理学雑誌   Vol. 130   page: 112-116   2007

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  217. Involvement of hippocampal ERK1/2 in spatial working memory in rats. Reviewed

    Nagai T, Kamei H, Dohniwa M, Takayanagi M, Suzuki M, Matsuya T, Nabeshima T, Takuma K and Yamada K

    NeuroReport   Vol. 17   page: 1453-1457   2006

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  218. a7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in b-amyloid infused rats. Reviewed

    Chen L, Yamada K, Nabeshima T and Sokabe M

    Neuropharmacology   Vol. 50   page: 254-268   2006

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  219. The magnetism responsive gene Ntan1 in mouse brain. Reviewed

    Goto Y, Taniura H, Yamada K, Hirai T, Sanada N, Nakamichi N and Yoneda Y

    Neurochem. Int.   Vol. 49   page: 334-341   2006

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  220. Effect of fructose-rich high fat diet on glucose sensitivity and atherosclerosis in non-human primate. Reviewed

    Suzuki M, Yamamoto D, Suzuki T, Fujii M, Suzuki N, Fujishiro M, Sakurai T and Yamada K

    Methods Find. Exp. Clin. Pharmacol.   Vol. 28   page: 609-617   2006

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  221. High fat and high fructose diet induced intracranial atherosclerosis and enhanced vasoconstrictor responses in non-human primate. Reviewed

    Suzuki M, Yamamoto D, Suzuki T, Fujii M, Suzuki N, Fujishiro M, Sakurai T and Yamada K

    Life Sci.   Vol. 80   page: 200-204   2006

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  222. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. Reviewed

    Yoshida S, Maeda M, Kaku S, Hisao Ikeya H, Yamada K and Nakaike S

    J Neural Transm.   Vol. 113   page: 1803-1814   2006

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  223. Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds. Reviewed

    Yan Y, Nitta A, Mizuno T, Nakajima A, Yamada K and Nabeshima T

    Behav. Brain Res.   Vol. 173   page: 39-46   2006

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  224. Relapse of methamphetamine-seeking behavior in C57BL/6J mice demonstrated by a reinstatement procedure involving intravenous self-administration. Reviewed

    Yan Y, Nitta A, Mizoguchi H, Yamada K and Nabeshima T

    Behav. Brain Res.   Vol. 168   page: 137-143   2006

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  225. Effects of single and repeated administration of methamphetamine or morphine on neuroglycan C gene expression in the rat brain. Reviewed

    Ishikawa K, Nitta A, Mizoguchi H, Mohri A, Murai R, Miyamoto Y, Noda Y, Kitaichi K, Yamada K and Nabeshima T

    Int. J. Neuropsychopharmacol.   Vol. 9   page: 407-415   2006

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  226. 中枢神経系のアポトーシスにおけるミトコンドリアの役割に関する研究.

    田熊一敞,山田清文,松田敏夫

    日本薬理学雑誌   Vol. 127   page: 349?354   2006

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  227. モルヒネ依存形成における組織プラスミノーゲン活性化因子の役割.

    永井拓,鍋島俊隆,田熊一敞,山田清文

    日本アルコール・薬物医学会雑誌   Vol. 41   page: 23-30   2006

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  228. 覚せい剤により誘発される記憶障害―発症機構と薬物治療

    山田清文

    医学のあゆみ   Vol. 217   page: 1171-1173   2006

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  229. Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK 1/2 activation in the prefrontal cortex. Reviewed

    Kamei H, Nagai T, Nakano H, Togan Y, Takayanagi M, Takahashi K, Kobayashi K, Yoshida S, Maeda K, Takuma K, Nabeshima T and Yamada K

    Biol. Psychiatry   Vol. 59   page: 75-84   2006

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  230. 入院患者における末梢静脈カテーテルの閉塞に対するヘパリンロックの効果 Reviewed

    郡司聖子、古川裕之、宮下知治、西村元一、安藤絹子、坂尾雅子、飛田敦子、山田清文、宮本謙一

    医療薬学   Vol. 32   page: 87-95   2006

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  231. 卵巣摘出ラットのストレス誘発性認知障害に対するラロキシフェンの効果 Reviewed

    保科有希,小池浩司,姫野友紀子,鈴木信孝,村上弘一,田熊一敞,井上正樹,山田清文

    日本更年期医学会雑誌   Vol. 14   page: 232-239   2006

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  232. *The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1. Reviewed

    Nagai T, Ito M, Nakamichi N, Mizoguchi H, Kamei H, Fukakusa A, Nabeshima T, Takuma K and Yamada K

    J. Neurosci.   Vol. 26   page: 12374-12383   2006

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  233. Involvement of tissue plasminogen activator-plasmin system in depolarization-evoked dopamine release in the nucleus accumbens of mice. Reviewed

    Ito M, Nagai T, Kamei H, Nakamichi N, Nabeshima T, Takuma K and Yamada K

    Mol. Pharmacol.   Vol. 70   page: 1720-1725   2006

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  234. Effects of memantine and donepezil on amyloid b-induced memory impairment in a delayed-matching to position task in mice. Reviewed

    Yamada K, Takayanagi M, Kamei H, Nagai T, Dohniwa M, Kobayashi K, Yoshida S, Ohhara T, Takuma K and Nabeshima T

    Behav. Brain Res.   Vol. 162   page: 191-199   2005

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  235. Aberrant expression and mutations of TGF-b receptor type II gene in endometrial cancer. Reviewed

    Sakaguchi J, Kyo S, Kanaya T, Maida Y, Hashimoto M, Nakamura M, Yamada K and Inoue M

    Gynecol. Oncol.   Vol. 98   page: 427-433   2005

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  236. 覚せい剤および麻薬に共通する依存関連分子の検索

    山田清文、永井拓、中島晶、鍋島俊隆

    日本薬理学雑誌   Vol. 126   page: 49-53   2005

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  237. Mitochondrial dysfunction, endoplasmic reticulum stress and apoptosis in Alzheimer's disease.

    Takuma K, Yan SS, Stern DM and Yamada K

    J. Pharmacol. Sci.   Vol. 97   page: 312-316   2005

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  238. Drug dependence, synaptic plasticity, and tissue plasminogen activator.

    Yamada K, Nagai T and Nabeshima T

    J. Pharmacol. Sci.   Vol. 97   page: 157-161   2005

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  239. Amyloid pathology and protein kinase C (PKC): possible therapeutics effects of PKC activators.

    Olariu A, Yamada K and Nabeshima T

    J. Pharmacol. Sci.   Vol. 97   page: 1-5   2005

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  240. 薬物依存と前頭前野

    亀井浩行、野田幸裕、山田清文、鍋島俊隆

    Clinical Neuroscience (臨床神経科学)   Vol. 23   page: 682-684   2005

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  241. 脳と組織プラスミノーゲン活性化因子

    永井拓、田熊一敞、山田清文

    脳21   Vol. 8   page: 437-442   2005

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  242. グリア細胞の遅発性アポトーシス

    田熊一敞、山田清文、松田敏夫

    Clinical Neuroscience (臨床神経科学)   Vol. 23   page: 181-183   2005

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  243. 遺伝子改変動物における情動性の評価

    永井拓、山田清文、鍋島俊隆

    日本薬理学雑誌   Vol. 125   page: 71-76   2005

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  244. Modification by the tissue plasminogen activator-plasmin system of morphine-induced dopamine release and dopamine-dependent hyperlocomotion, but not antinociceptive effect in mice. Reviewed

    Nagai T, Kamei H, Ito M, Hashimoto K, Takuma K, Nabeshima T and Yamada K

    J. Neurochem.   Vol. 93   page: 1272-1279   2005

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  245. Prostaglandin E receptor EP1 controls impulsive behavior under stress. Reviewed

    Matsuoka Y, Furuyashiki T, Yamada K, Nagai T, Bito H, Tanaka Y, Kitaoka S, Ushikubi F, Nabeshima T and Narumiya S

    Proc. Natl. Acad. Sci. USA   Vol. 102   page: 16066-16071   2005

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  246. The role of tissue plasminogen activator in methmphetamine-related reward and sensitization. Reviewed

    Nagai T, Noda Y, Ishikawa K, Miyamoto Y, Yoshimura Y, Ito M, Takayanagi M, Takuma K, Yamada K and Nabeshima T

    J. Neurochem.   Vol. 92   page: 660-667   2005

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  247. ホルモン療法に抵抗を示す更年期の欝・不安症状に対する温経湯の有効性の検討 Reviewed

    松尾亜伊、小池浩司、保科有希、村上弘一、井上正樹、大野智、鈴木信孝、山田清文、高橋紀子

    産婦人科 漢方研究のあゆみ   Vol. 22   page: 70-74   2005

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  248. The interaction between the cholinergic and dopaminergic system in learning and memory process in rats. Reviewed

    Hefco V, Yamada K, Hefco A, Hritcu L, Tiron A, Nabeshima T.

    Rom. J. Physiol.   Vol. 41   page: 21-30   2004

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  249. Expression of estrogen receptor-b in the postischemic monkey hippocampus. Reviewed

    Takahashi N, Tonchev AB, Koike K, Murakami K, Yamada K, Yamashima T and Inoue M

    Neurosci. Lett.   Vol. 369   page: 9-13   2004

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  250. Anatomical substrates for the discriminative stimulus effects of methamphetamine in rats. Reviewed

    Nakajima A, Yamada K, He J, Zeng N, Nitta A and Nabeshima T

    J. Neurochem.   Vol. 91   page: 308-317   2004

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  251. Enhanced antidepressant efficacy of s1 receptor agonist in rats after chronic intracerebroventricular infusion of b-amyloid-(1-40) protein. Reviewed

    Urai A, Romieu P, Roman F, Yamada K, Noda Y, Kamei, H, Tran HM, Nagai T, Nabeshima T and Maurice T

    Eur. J. Pharmacol.   Vol. 486   page: 151-161   2004

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  252. Efficacy of the herbal medicine Unkei-to as an adjunctive treatment to hormone replacement therapy for postmenopausal women with depressive symptoms. Reviewed

    Koike K, Ohno S, Takahashi N, Suzuki N, Nozaki N, Murakami K, Sugiura K, Yamada K and Inoue M

    Clin. Neuropharmacol.   Vol. 27   page: 157-162   2004

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  253. b-Amyloid(1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. Reviewed

    Jhoo JH, Kim KC, Nabeshima T, Yamada K, Shin EJ, Jhoo WK, Kim W, Kang KS, Jo SA and Woo JI

    Behav. Brain Res.   Vol. 155   page: 185-196   2004

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  254. Nefiracetam attenuates methamphetamine-induced discriminative stimulus effects in rats. Reviewed

    Yan Y, Mizuno T, Nitta A, Yamada K, Nabeshima T

    Ann. NY Acad. Sci.   Vol. 1025   page: 274-278   2004

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  255. Fos expression associated with the discriminative stimulus effects of methamphetamine in rats. Reviewed

    Zeng N, Nakajima A, He J, Nitta A, Yamada K and Nabeshima T

    Ann. NY Acad. Sci.   Vol. 1025   page: 236-241   2004

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  256. Pro- and anti-addictive neurotrophic factors and cytokines in psychostimulant addiction.

    Yamada K and Nabeshima T

    Ann. NY Acad. Sci.   Vol. 1025   page: 198-204   2004

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  257. Oxidative stress mechanism of amyloid b-peptide-induced impairment of neurotransmission and memory.

    Nabeshima T, Tran MH, Kim KC and Yamada K

    Method Find. Exp. Clin. Pharmacol.   Vol. 26   page: 1-3   2004

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  258. Interaction of BDNF/TrkB signaling and NMDA receptors in learning and memory.

    Yamada K, Mizuno M and Nabeshima T

    Drug News Perspect.   Vol. 17   page: 1-4   2004

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  259. Behavioral adaptations to addictive drugs in mice lacking NMDA receptor e1 subunit. Reviewed

    Miyamoto Y, Yamada K, Nagai T, Mori, H, Mishina M, Furukawa H, Noda Y and Nabeshima T

    Eur. J. Neurosci.   Vol. 19   page: 151-158   2004

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  260. Regulation of methamphetamine reward by extracellualr signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors. Reviewed

    Mizoguchi H, Yamada K, Mizuno M, Mizuno T, Noda Y, Nitta A and Nabeshima T

    Mol. Pharmacol.   Vol. 65   page: 1293-1301   2004

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  261. Role of TNF-a in methamphetamine-induced drug dependence and neurotocicity. Reviewed

    Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC and Nabeshima T

    J. Neurosci.   Vol. 24   page: 2212-2225   2004

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  262. *Tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release. Reviewed

    Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto M, Hashimoto K, Noda Y, Nitta A and Nabeshima T

    Proc. Natl. Acad. Sci. USA.   Vol. 101   page: 3650-3655   2004

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  263. Immunocytochemical evidence that b-amyloid (1-42) impairs endogenous antioxidant systems in vivo. Reviewed

    Kim, HC, Yamada K, Olariu A, Tan MH, Jhoo WK, Im DH, Shin EJ, Park SC, Kato K, Hjelle OP, Mirault ME and Nabeshima T

    Neuroscience   Vol. 119   page: 399-419   2003

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  264. 新規老化促進モデルマウス、Klotho遺伝子変異マウスの認知障害

    永井 拓、山田清文、鍋島陽一、鍋島俊隆

    分子精神医学   Vol. 3   page: 62-63   2003

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  265. BDNF/TrkB signaling in memory processes.

    Yamada K and Nabeshima T

    J Pharmacol Sci.   Vol. 91   page: 267-270   2003

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  266. 動物モデルからみた不安障害

    亀井浩行、野田幸裕、鍋島俊隆、山田清文

    最新精神医学   Vol. 8   page: 537-546   2003

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  267. Klotho遺伝子変異マウスの学習障害と酸化ストレス

    永井 拓、山田清文、Hyoung Chun Kin、野田幸裕、鍋島陽一、鍋島俊隆

    日本神経精神薬理学雑誌   Vol. 23   page: 211-217   2003

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  268. 神経精神疾患におけるシグマ受容体リガンドの作用

    亀井浩行、野田幸裕、鍋島俊隆、山田清文

    日本神経精神薬理学雑誌   Vol. 23   page: 187-196   2003

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  269. 薬物依存におけるサイトカインの役割について

    中島 晶、山田清文、鍋島俊隆

    日本神経精神薬理学雑誌   Vol. 23   page: 179-182   2003

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  270. グルタミン酸受容体の修飾と薬物依存

    亀井浩行、山田清文、鍋島俊隆

    分子精神医学   Vol. 3   page: 140-146   2003

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  271. 大学院修士課程臨床薬学講義ならびに実務実習のVisual Analog Scale法による客観的評価 Reviewed

    成橋和正、野村政明、亀井浩行、小野俊介、松下 良、清水 栄、横川弘一、山田清文、鈴木永雄、宮本謙一、木村和子

    YAKUGAKU ZASSHI   Vol. 123   page: 973-980   2003

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  272. Neuronal mechanism of nociceptin-induced modulation of learning and memory: Involvement of N-methyl-D-aspartate receptors. Reviewed

    Mamiya T, Yamada K, Miyamoto Y, Watanabe Y, Noda Y and Nabeshima T

    Mol. Psychiat.   Vol. 8   page: 752-765   2003

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  273. *Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid b-peptide-induced cholinergic dysfunction. Reviewed

    Tran MH, Yamada K, Nakajima A, Mizuno M, He J, Kamei H and Nabeshima T

    Mol. Psychiat.   Vol. 8   page: 407-412   2003

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  274. Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Reviewed

    Mizuno M, Yamada K, Takei N, Tran MH, He J, Nakajima A, Nawa H and Nabeshima T

    Mol. Psychiat.   Vol. 8   page: 217-224   2003

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  275. Interaction of BDNF receptor TrkB and NMDA receptors in spatial memory formation. Reviewed

    Mizuno M, Yamada K, He J, Nakajima A, Kawano Y, Makino K and Nabeshima T

    Learn. Mem.   Vol. 10   page: 108-115   2003

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  276. Improvement in drug compliance by medical consultation at a pharmacist outpatients' clinic (Part 2). Reviewed

    Maruyama T, Sugiura S, Kojima J, Arimasa Y, Satoh Y, Kanaji K, Matsumura T, Ohsumi K, Yamada K and Nabeshima T

    J. Appl Therapeut. Res.   Vol. 4   page: 25-33   2003

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  277. Improvement in drug compliance by medical consultation at a pharmacist outpatients' clinic (Part 1). Reviewed

    Maruyama T, Sugiura S, Kojima J, Arimasa Y, Satoh Y, Kanaji K, Matsumura T, Ohsumi K, Yamada K and Nabeshima T

    J. Appl Therapeut. Res.   Vol. 4   page: 18-24   2003

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  278. Cognition impairment in the genetic model of aging, klotho gene mutant mice: a role of oxidative stress. Reviewed

    Nagai T, Yamada K, Kim HC, Kim, YS, Noda Y, Imura A, Nabeshima Y and Nabeshima T

    FASEB J.   Vol. 17   page: 50-52   2003

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  279. Effects of nicotine on memory impairment induced by blockade of muscarinic, nicotinic and dopamine D2 receptors in rats. Reviewed

    Hefco V, Yamda K, Hefco A, Hritcu L, Tiron A, Olariu A. and Nabeshima T

    Eur. J. Pharmacol.   Vol. 474   page: 227-232   2003

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  280. Role of mesotelencephalic dopamine system in learning and memory processes in rats. Reviewed

    Hefco V, Yamda K, Hefco A, Hritcu L, Tiron A and Nabeshima T:

    Eur. J. Pharmacol.   Vol. 475   page: 55-60   2003

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  281. Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrier. Reviewed

    Kitagami T, Yamada K, Miura H, Hashimoto R, Nabeshima T and Ohta T

    Brain Res.   Vol. 978   page: 104-114   2003

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  282. 記憶の神経メカニズム‐BDNFを中心とした分子シグナルによる制御‐

    水野 誠、山田清文、鍋島俊隆

    脳と精神の医学   Vol. 13   page: 389-396   2002

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  283. Therapeutic approaches for the treatment of Alzheimer's disease.

    Yamada K Kamei Y and Nabeshima T

    Drugs Today   Vol. 38   page: 631-637   2002

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  284. Amyloid b-peptide induces cholinergic dysfunction and cognitive deficits.

    Tran MH, Yamada K and Nabeshima T

    Peptides   Vol. 23   page: 1271-1283   2002

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  285. Oxidative stress in amyloid b-peptide-induced cholinergic dysfunction and cognitive deficits.

    Tran MH, Yamada K and Nabeshima T

    Jpn. J. Neuropsychopharmacol.   Vol. 21   page: 125-132   2002

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  286. Role for brain-derived neurotrophic factor in learning and memory.

    Yamada K, Mizuno M and Nabeshima T

    Life Sci.   Vol. 70   page: 735-744   2002

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  287. インターネットで学ぶ医療薬学講座 Reviewed

    木村和子、松下良、柳川さおり、清水栄、成橋和正、鈴木永雄、山田清文、辻彰、渡辺珠代、石橋弘行

    医薬品情報学   Vol. 7   page: 15-19   2002

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  288. Absorption of cyclosporin (Neoral) from a microemulsion formulation in a living donor liver transplant recipient. Reviewed

    Maeda Y, Kuzuya T, Ota S, Yamada K, Kobayashi T, Hayashi S, Yokoyama I, Nakao A and Nabeshima T

    Transplant. P.   Vol. 34   page: 2784-2787   2002

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  289. A role of Fos expression in the CA3 region of the hippocampus in spatial memory formation in rats. Reviewed

    He J, Yamada K and Nabeshima T

    Neuropsychopharmacology   Vol. 26   page: 259-268   2002

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  290. Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor e4 subunit. Reviewed

    Miyamoto Y, Yamada K, Noda Y, Mori H, Mishina M and Nabeshima T

    J. Neurosci.   Vol. 22   page: 2335-2342   2002

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  291. Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levels. Reviewed

    Nakajima A, Yamada K, Zou L.B., Yan Y., Mizuno M. and Nabeshima T

    Free Radic. Biol. Med.   Vol. 32   page: 1324-1332   2002

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  292. Memory impairment induced by chronic intracerebroventricular infusion of b-amyloid (140) involves downregulation of protein kinase C. Reviewed

    Olariu A, Yamada K, Mamiya T, Hefco V and Nabeshima T

    Brain Res.   Vol. 957   page: 278-286   2002

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  293. The effect of dietary fiber on morphine-induced constipation in rats. Reviewed

    Niwa T, Nakao M, Hoshi S, Yamada K, Inagaki K, Nishida M and Nabeshima T

    Biosci. Biotechnol. Biochem.   Vol. 66   page: 1233-1240   2002

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  294. Learning and memory in two different reward tasks in a radial arm maze in rats. Reviewed

    He J, Yamada K, Nakashima A, H. Kamei and Nabeshima T

    Behav. Brain Res.   Vol. 134   page: 139-149   2002

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  295. CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. Reviewed

    Mizuno M, Yamada K, Maekawa N, Saito K, Seishima M and Nabeshima T

    Behav. Brain Res.   Vol. 133   page: 135-141   2002

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  296. 名古屋大学病院における治験コーディネーターの取り組みとその成果 Reviewed

    亀井浩行、加藤経子、安藤幸子、成瀬由香里、市野真弓、白木比奈子、堅田早紀子、加藤純子、宮澤憲治、新出千聡、加藤英里、土井千香子、宇野雅子、葛谷孝文、村岡 勲、伊藤幸代、大原洋子、山田清文、吉田 純、鍋島俊隆、石黒直樹

    臨床薬理   Vol. 33   page: 85-91   2002

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  297. 治験の品質管理における治験コーディネーターの役割 Reviewed

    亀井浩行、安藤幸子、加藤経子、成瀬由香里、市野真弓、白木比奈子、堅田早紀子、加藤純子、宮澤憲治、新出千聡、加藤英里、土井千香子、宇野雅子、葛谷孝文、村岡 勲、伊藤幸代、大原洋子、山田清文、石黒直樹、鍋島俊隆

    臨床薬理   Vol. 34   page: 19-23   2002

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  298. Alzheimer病の薬物療法と創薬

    鍋島俊隆、山田清文

    医学のあゆみ   Vol. 196   page: 224-227   2001

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  299. 我が国における抗痴呆薬の開発状況(2000年3月現在)

    長谷川雅哉、野田幸裕、前田洋子、亀井浩行、山田清文、鍋島俊隆

    臨床精神薬理   Vol. 4   page: 399-410   2001

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  300. A selective phosphodiesterase IV inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice. Reviewed

    Hamdy MM, Mamiya T, Noda Y, Sayed M, Assi A-A, Gomaa A, Yamada K and Nabeshima T

    Behav. Brain Res.   Vol. 118   page: 85-93   2001

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  301. Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking NMDA receptor e1 subunit. Reviewed

    Miyamato Y, Yamada K, Noda Y, Mori H, Mishina M and Nabeshima T:

    J. Neurosci.   Vol. 21   page: 750-757   2001

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  302. Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats. Reviewed

    He J, Yamada K Zou, L-B and Nabeshima T

    J. Neural Transm.   Vol. 108   page: 1435-1443   2001

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  303. Memory deficits and increased emotionality induced by b-amyloid(25-25) are correlated with the reduced acetylcholine release and altered phorbol dibutyrate binding in the hippocampus. Reviewed

    Olariu A, Tran MH, Yamada K, Mizuno M, Hefco V and Nabeshima T

    J. Neural Transm.   Vol. 108   page: 1065-1079   2001

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  304. Amyloid b-peptide induces nitric oxide production in rat hippocampus: association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors. Reviewed

    Tran MH, Yamada K, Olariu A, Mizuno M, Ren XH and Nabeshima T

    FASEB. J.   Vol. 15   page: 1407-1409   2001

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  305. Involvement of the cyclic AMP systems in morphine physical dependence in mice: prevention of development of dependence by rolipram, a phosphodiesterase IV inhibitor. Reviewed

    Mamiya T, Noda Y, Ren X, Hamdy M, Furukawa S, Kameyama T, Yamada K and Nabeshima T

    Br. J. Pharmacol.   Vol. 132   page: 1111-1117   2001

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  306. 抗痴呆薬の開発の現状と将来

    鍋島俊隆、山田清文、野田幸裕、長谷川雅哉、村岡 勲

    応用薬理   Vol. 59   page: 1-9   2000

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  307. Animal models of Alzheimer's disease and evaluation of anti-dementia drugs.

    Yamada K and Nabeshima T

    Pharmacol. Therapeut.   Vol. 88   page: 93-113   2000

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  308. Neurotrophic factor strategies for the treatment of Alzheimer disease.

    Nabeshima T and Yamada K

    Alzheimer Dis. Assoc. Disord.   Vol. 14   page: S39-46   2000

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  309. 抗痴呆薬の進歩

    山田清文、鍋島俊隆

    Pharm Medica   Vol. 18   page: 73-77   2000

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  310. 抗痴呆薬開発の戦略:NGFの観点から

    水野 誠、山田清文、鍋島俊隆

    老年精神医学雑誌   Vol. 11   page: 154-160   2000

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  311. β-アミロイド蛋白の脳室内持続注入によるアルツハイマー型痴呆動物モデルの作製と今後の展望

    伊東亜紀雄、山田清文、鍋島俊隆

    CRJ Letters   Vol. 13   page: 1-8   2000

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  312. 痴呆症の治療と予防:グルタメイト受容体作用薬

    前田洋子、山田清文、鍋島俊隆

    Pharm Medica   Vol. 18   page: 81-86   2000

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  313. 抗痴呆薬の開発動向と21世紀における痴呆の薬物療法

    小野寺憲治、山田清文、鍋島俊隆

    臨床と薬物治療   Vol. 19   page: 10-18   2000

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  314. インビボダイアリシスによる脳内一酸化窒素(NO)代謝物の測定

    山田清文、鍋島俊隆

    日本薬理学雑誌   Vol. 115   page: 99-104   2000

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  315. Suppression of neurocognitive damage in LP-BM5 infected mice with a targeted deletion of the TNFa gene. Reviewed

    Iida R, Saito K, Yamada K, Basile AS, Sekikawa K, Takemura M, Fujii H, Wada H, Seishima M and Nabeshima T

    FASEB J.   Vol. 14   page: 1023-1031   2000

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  316. Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice. Reviewed

    Mamiya T, Noda Y, Noda A, Hiramatsu M, Karasawa T, Kameyama T, Furukawa S, Yamada K, and Nabeshima T

    Neuropharmacology   Vol. 39   page: 2391-2398   2000

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  317. Effects of? s1 receptor agonist SA4503 and neuroactive steroids on performance in a raidal arm maze task in rats. Reviewed

    Zou L-B, Yamada K, Sasa M, Nakata Y and Nabeshima T

    Neuropharmacology   Vol. 39   page: 1617-1627   2000

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  318. Spatiotemporal expression of BDNF in the hippocampus induced by the continuous intracerebroventricular infusion of b-amyloid in rats. Reviewed

    Tang P-Y, Yamada K, Kanou Y, Miyazaki T, Xiong X-L, Kambe F, Murata Y, Seo H and Nabeshima T

    Mol. Brain Res.   Vol. 80   page: 188-197   2000

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  319. *Involvement of BDNF in spatial memory formation and maintenance in a radial arm maze test in rats. Reviewed

    Mizuno M, Yamada K, Olariu A, Nawa H and Nabeshima T

    J. Neurosci.   Vol. 20   page: 7116-7121   2000

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  320. Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-a gene: implications for emotional behavior. Reviewed

    Yamada K, Iida R, Miyamoto Y, Saito K, Sekikawa K, Seishima M and Nabeshima T

    J. Neuroimmunol.   Vol. 111   page: 131-138   2000

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  321. Involvement of nitric oxide in pentylenetetrazol-induced kindling in rats. Reviewed

    Han D, Yamada K, Senzaki K, Xiong H, Nawa H and Nabeshima T

    J. Neurochem.   Vol. 74   page: 792-798   2000

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  322. Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, amurine model of AIDS. Reviewed

    Iida R, Yamada K, Mamiya T, Saito K, Seishima M and Nabeshima T

    J. Neuroimmunol.   Vol. 95   page: 65-72   1999

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  323. 平成10年度厚生科学研究費補助金医薬安全総合研究事業「医薬品の適正使用における病院薬剤師の役割」―外国人研究者招聘事業(東海・関西地区)―

    鍋島俊隆、松葉和久、岡田 啓、全田 浩、奥村勝彦、横山昭由、菅家浦子、山田清文

    日本病院薬剤師会雑誌   Vol. 35   page: 1287-1291   1999

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  324. 我が国における抗痴呆薬の開発状況(1999年3月現在)

    長谷川雅哉、野田幸裕、前田洋子、山田清文、鍋島俊隆

    日本薬理学雑誌   Vol. 114   page: 327-336   1999

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  325. Protective effects of idebenone and α-tocopherol on β-amyloid-(1-42) induced learning and memory deficits in rats : implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo (共著) Reviewed

    Yamada K, Tanaka T, Han D, Senzaki K, Kameyama T and Nabeshima T

    Eur. J. Neurosci.   Vol. 11 ( 11 ) page: 83-90   1999

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  326. Impairments of nicotinic signal transduction and long-term potentiation in hippocampal slices of β-amyloid-infused rats. Reviewed

    Itoh A, Akaike T, Sokabe M, Nitta A, Iida R, Olariu A, Yamada K and Nabeshima T

    Eur. J. Pharmacol.   Vol. 382   page: 167-175   1999

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  327. Regulation of nerve growth factor release by nitric oxide in cortical glial cells. Reviewed

    Xiong H, Yamada K, Jourdi H, Kawamura M, Takei N, Han D, Nabeshima T and Nawa H

    Mol. Pharmacol.   Vol. 56   page: 339-347   1999

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  328. Long-term deprivation of estrogens by ovariectomy potentiates β-amyloid-indued working memory deficits in rats. Reviewed

    Yamada K, Tanaka T, Zou L-B, Senzaki K, Yano K, Osada T, Olariu A, Ren X, Kameyama T and Nabeshima T

    Br. J. Pharmacol.   Vol. 128   page: 419-427   1999

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  329. Mutual regulation between the intercellular messengers nitric oxide and brain-derived neurotrophic factor in rodent neocortical neurons. Reviewed

    Xiong H, Yamada K, Han D, Nabeshima T, Enikolopov G, Carnahan J and Nawa H

    Eur. J. Neurosci.   Vol. 11   page: 1567-1576   1999

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  330. 学習・記憶とレセプター

    前田洋子、山田清文、鍋島俊隆

    Pharm D   Vol. 2   page: 31-35   1999

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  331. Perspectives of pharmacotherapy in Alzheimer's disease. Reviewed

    Yamada K, Ren X and Nabeshima T

    Jpn. J. Pharmacol.   Vol. 80   page: 9-14   1999

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  332. 治験に係わる診療の特定療養費制度の問題点

    葛谷孝文、加藤勝義、山田清文、鍋島俊隆

    日本病院薬剤師会雑誌   Vol. 35   page: 1507-1510   1999

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  333. ラット脳室内へのβ-アミロイド蛋白の持続注入により誘発される学習記憶障害の発現機序

    山田清文、鍋島俊隆

    医科学応用研究財団研究報告   Vol. 18   page: 178-182   1999

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  334. Brain dysfunction associated with an induction of nitric oxide synthase following an intracerebral injection of lipopolysaccharide in rats. Reviewed

    Yamada K, Komori Y, Tanaka T, Senzaki K, Nikai T, Sugihara H, Kameyama T and Nabeshima T

    Neuroscience   Vol. 88   page: 281-294   1999

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  335. Improvement of nefiracetam of β-amyloid-(1-42)-induced learning and memory impairment in rats. Reviewed

    Yamada K, Tanaka T, Mamiya T, Shiotani T, Kameyama T and Nabeshima T

    Br. J. Pharmacol.   Vol. 126   page: 235-244   1999

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  336. Two phases of behavioral plasticity in rats following unilateral excitotoxic lesion of the hippocampus. Reviewed

    Zou L-B, Yamada K, Sasa M and Nabeshima T

    Neuroscience   Vol. 92   page: 819-826   1999

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  337. The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (s) receptor ligands involves both s1 and s2 sites. Reviewed

    Maurice T, Phan V, Noda Y, Yamada K, Privat A and Nabeshima T

    Br. J. Pharmacol.   Vol. 127   page: 335-342   1999

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  338. Changes in NMDA receptor/nitric oxide signaling pathway in the brain with aging.

    Yamada K and Nabeshima T

    Microsc. Res. Techniq.   Vol. 43   page: 68-74   1998

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  339. Propentofylline improves learning and memory deficits induced in rats by β-amyloid protein-(1-40). Reviewed

    Yamada K, Tanaka T, Senzaki K, Kameyama T and Nabeshima T

    Eur. J. Pharmacol.   Vol. 349   page: 15-22   1998

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  340. Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged Rats. Reviewed

    Miyagawa H, Hasegawa M, Fukuta T, Amano M, Yamada K and Nabeshima T

    Behav. Brain Res.   Vol. 91   page: 73-81   1998

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  341. 連合学習と長期増強

    山田清文、鍋島俊隆

    日本薬理学雑誌   Vol. 111   page: 190   1998

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  342. σ Receptor ligand(+)-SKF10047 and SA4503 improve dizocilpine-induced spatial memory deficits in rats Reviewed

    Zou L-B, Yamada K and Nabeshima T

    Eur. J. Pharmacol.   Vol. 355   page: 1-10   1998

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  343. NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by β-amyloid protein in rats. Reviewed

    Tanaka T, Yamada K, Senzaki K, Narimatsu M, Nishimura K, Kameyama T and Nabeshima T

    Eur. J. Pharmacol.   Vol. 352   page: 135-142   1998

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  344. 学習記憶過程におけるガス状情報伝達物質 一酸化窒素(NO)の役割の解明-最終報告-

        1998

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  345. 学習記憶における一酸化窒素の役割

    山田清文、鍋島俊隆

    医学のあゆみ   Vol. 183   page: 674-675   1998

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  346. 不老長寿の薬

    山田清文、鍋島俊隆

      Vol. 36   page: 71-74   1998

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  347. 学習記憶過程における一酸化窒素の役割

    山田清文

    日本薬理学雑誌   Vol. 111   page: 87-96   1998

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  348. Nitric oxide and cyclic GMP signaling pathway in learning and memory processes

    Yamada K and Nabeshima T

    Curr Top Pharmacol   Vol. 4   page: 77-86   1998

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  349. Modulation of nitric oxide production in vivo in the brain.

    Yamada K and Nabeshima T

    Meth. Find. Exp. Clin. Pharmacol.   Vol. 20   page: 601-605   1998

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  350. Nitric oxide synthase inhibitors impair reference memory formation in a radial arm maze task in rats. Reviewed

    Zou L-B, Yamada K, Tanaka T, Kameyama T and Nabeshima T

    Neuropharmacology   Vol. 37   page: 323-330   1998

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  351. 株化神経系細胞PC12におけるインターロイキン-6の細胞保護作用

    山田清文、梅垣宏行、井口昭久、鍋島俊隆

    臨床薬理の進歩   Vol. 18   page: 87-91   1997

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  352. Simultaneous measurement of nitrite and nitrate levels as indices of nitric oxide release in the cerebellum of conscious rats. Reviewed

    Yamada K and Nabeshima T

    J. Neurochem.   Vol. 68   page: 1234-1243   1997

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  353. 学習記憶過程におけるガス状情報伝達物質 一酸化窒素(NO)の役割の解明-中間報告-

      Vol. 24   page: 90   1997

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  354. Orally active NGF synthesis stimulators: Potential therapeutic agents in Alzheimer's disease.

    Yamada K, Nitta A, Hasegawa T, Fuji K, Hiramatsu M, Kameyama T, Furukawa Y, Hayashi K and Nabeshima T

    Behav. Brain Res.   Vol. 83   page: 117-122   1997

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  355. Role of nitric oxide in the effect of aging on spatial memory in rats. Reviewed

    Noda Y, Yamada K and Nabeshima T

    Behav. Brain. Res.   Vol. 83   page: 153-158   1997

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  356. No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging. Reviewed

    Yamada K, Nishiwaki K, Hattori K, Senzaki K, Nagata M, Komatsu T, Simada Y and Nabeshima T

    J. Neural Transm.   Vol. 104   page: 825-831   1997

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  357. 学習記憶過程における一酸化窒素の役割に関する研究

      Vol. 650   page: 8   1997

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  358. Two Pathways of nitric oxide production through glutamate receptors in the rat cerebellum in vivo. Reviewed

    Yamada K and Nabeshima T

    Neurosci. Res.   Vol. 28   page: 93-102   1997

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  359. Changes in extracellular nitrite and nitrate levels after inhibition of glial metabolism with fluorocitrate. Reviewed

    Yamada K, Senzaki K, Komori Y, Nikai T, Sugihara H and Nabeshima T

    Brain Res.   Vol. 762   page: 72-78   1997

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  360. Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells. Reviewed

    Yamada K, Umegaki H, Maezawa I, Iguchi A, Kameyama T and Nabeshima T

    Brain Res. Bull.   Vol. 43   page: 573-577   1997

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  361. Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore. Reviewed

    Umegai H, Yamada K, Naito M, Kameyama T, Iguchi A and Nabeshima T

    Biochem. Pharmacol.   Vol. 52   page: 911-916   1996

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  362. Nefiracetam (DM-9384): a novel antiamnesic drug.

    Yamada K and Nabeshima T

    CNS Drug Rev.   Vol. 2   page: 322-342   1996

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  363. The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice. Reviewed

    Yamada K, Noda Y, Hasegawa T, Komori Y, Nikai T, Sugihara H and Nabeshima T

    J. Pharmacol. Exp. Ther.   Vol. 276   page: 460-466   1996

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  364. NGFの産生を促進する薬剤について

    FAX DIニュース   Vol. 119   page: 1   1996

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  365. Role of dopaminergic neuronal system in dizocilpine-induced acethylcholine release in the rat brain. Reviewed

    Hasegawa M, Yamada K, Hasegawa T and Nabeshima T

    J. Neural Transm.   Vol. 103   page: 651-660   1996

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  366. Effects of dietary vegetable oils on behavior and drug responses in mice. Reviewed

    Kameyama T, Ohhara T, Nakashima Y, Naito Y,Huang M, Watanabe S, Kobayashi T, Okuyama H, Yamada K and Nabeshima T

    Biol. Pharm. Bull.   Vol. 19   page: 400-404   1996

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  367. シグマ受容体リガンドの中枢薬理作用、-抗不安作用、学習記憶障害改善作用および脳保護作用を中心に-

    天野 学、山田清文、松野 聖、鍋島俊隆

    日本神経精神 薬理学雑誌   Vol. 16   page: 73-84   1996

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  368. Role of nitric oxide and cyclic GMP in the dizocilpine-induced impairment of spontaneous alternation behavior in mice. Reviewed

    Yamada K, Hiramatsu M, Noda Y, Mamiya T, Murai M, Kameyama T, Komori Y, Nikai T, Sugihara H and Nabeshima T

    Neuroscience   Vol. 74   page: 365-374   1996

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  369. Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats. Reviewed

    Yamada K, Noda Y, Komori Y, Sugihara H, Hasegawa T and Nabeshima T

    Neurosci. Res.   Vol. 24   page: 393-402   1996

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  370. Role of nitric oxide in the development of tolerance and sensitization to behavioral effects of phencyclidine in mice. Reviewed

    Noda Y, Yamada K, Komori Y, Sugihara H, Furukawa H and Nabeshima T

    Br. J. Pharmacol.   Vol. 117   page: 1579-1585   1996

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  371. Effects of the subacute administration of nefiracetam on abnormal behavior in aged rats. Reviewed

    Hasegawa M, Nakayama S, Kinoshita H, Amano M, Yamada K, Hasegawa T, and Nabeshima T

    Behav. Brain. Res.   Vol. 78   page: 93-100   1996

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  372. Neuronal mechanism of the inhibitory effects of calcitonin on N-methyl-D-aspartate-induced aversive behavior. Reviewed

    Maeda Y, Yamada K, Hasegawa T and Nabeshima T

    Eur. J. Pharmacol.   Vol. 275   page: 163-170   1995

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  373. Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40)protein. Reviewed

    Yamada K, Nitta A, Saito T, Hu J and Nabeshima T

    Neurosci. Lett.   Vol. 201   page: 155-158   1995

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  374. Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. Reviewed

    Yamada K, Kono K, Umegaki H, Yamada K, Iguchi A, Fukatsu T, Nakashima N, Nishiwaki H, Shimada Y, Sugita Y, Yamamoto T, Hasegawa T and Nabeshima T

    Neurosci. Lett.   Vol. 186   page: 219-221   1995

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  375. Stress-induced behavioral responses and multiple opioid systems in the brain.

    Yamada K and Nabeshima T

    Behav. Brain Res.   Vol. 67   page: 133-145   1995

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  376. Possible involvement of nitric oxide in quinolinic acid-induced convulsion in mice. Reviewed

    Nakamura T, Yamada K, Hasegawa T and Nabeshima T

    Pharmacol. Biochem. Behav.   Vol. 51   page: 309-312   1995

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  377. NOによる脳機能の調節

    山田清文、鍋島俊隆

      Vol. 32   page: 893-894   1995

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  378. Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine : a new model of schizophrenia. Reviewed

    Noda Y, Yamada K, Furukawa H and Nabeshima T

    Br. J. Pharmacol.   Vol. 116   page: 2531-2537   1995

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  379. 強制水泳時の無動状態に対するphencyclidineによる影響

    野田幸裕、山田清文、中山忍、長谷川高明、古川宏、鍋島俊隆

      Vol. 21   page: 131-134   1995

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  380. サイトカインの神経栄養因子作用と神経疾患

    山田清文、鍋島俊隆

      Vol. 10   page: 605-608   1995

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  381. Phencyclidine increases the extracellular acetylcholine level in the parietal cortex partly through sigma receptors. Reviewed

    Ohzeki M, Hasegawa M, Katoh T, Yamada K, Hasegawa T, Furukawa H and Nabeshima T

    Res. Commun. Alcohol Sub. Abuse   Vol. 16   page: 97-103   1995

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  382. Involvement of nitric oxide in phencyclidine-induced hyperlocomotion in mice. Reviewed

    Noda Y, Yamada K, Furukawa H and Nabeshima T

    Eur. J. Pharmacol.   Vol. 286   page: 291-297   1995

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  383. The attenuation of suppression of motility by triazolam in the conditioned fear stress task in exacerbated by ethanol in mice. Reviewed

    Kitaichi K, Minami Y, Amano M, Yamada K, Hasegawa T and Nabeshima T

    Life Sci.   Vol. 57   page: 743-753   1995

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  384. Role of nitric oxide in learning and memory and in monoamine metabolism in the brain of rats. Reviewed

    Yamada K, Noda Y, Nakayama S, Komori Y, Sugihara H, Hasegawa T and Nabeshima T

    Br. J. Pharmacol.   Vol. 115   page: 852-858   1995

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  385. Possible involvement of the activation of voltage-sensitive calcium channels in the ameliorating effects of nefiracetam on scopolamine-induced impairment of performance in a passive avoidance task. Reviewed

    Yamada K, Nakayama S, Shiotani T, Hasegawa T and Nabeshima T

    J. Pharmacol. Exp. Ther.   Vol. 270   page: 881-892   1994

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  386. Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task. Reviewed

    Nabeshima T, Nakayama S, Ichihara K, Yamada K, Shiotani T and Hasegawa T

    Eur. J. Pharmacol.   Vol. 255   page: 57-65   1994

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  387. ω-Conotoxin GVIA inhibits methylphenidate-induced but not methamphetamine-induced behavior. Reviewed

    Yamada K, Teraoka T, Seiji M, Hasegawa T and Nabeshima T

    Neurosci. Lett.   Vol. 165   page: 191-194   1994

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  388. Inhibitory effects of salmon salcitonin on the tail-biting and scratching behavior. Reviewed

    Maeda Y, Yamada K, Hasegawa T, Iyo M, Fukui S and Nabeshima T

    J. Neural Transm.   Vol. 96   page: 125-133   1994

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  389. Effects of Kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography. (2) Changes in GABAA and benzodiazepine receptor binding. Reviewed

    Yamada K, Hayashi T, Hasegawa T, Ishihara S, Kameyama T, Morimasa T, Kaneyuki T, Shohmori T and Nabeshima T

    Jpn. J. Pharmacol.   Vol. 66   page: 53-58   1994

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  390. Relationship between anti-aversive effects of salmon calcitonin and plasma levels of ACTH, beta-endorphin and prostaglandin E2 in mice. Reviewed

    Maeda Y, Yamada K, Hasegawa T, Kawamata Y, Uchida K, Iyo M, Fukui S and Nabeshima T

    Res. Commun. Chem. Pathol. Pharmacol.   Vol. 83   page: 15-24   1994

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  391. Effects of resperidone on phencyclidine-induced behavior : comparison with haloperidol and ritanserin. Reviewed

    Kitaichi K, Yamada K, Hasegawa T, Furukawa H and Nabeshima T

    Jpn. J. Pharmacol.   Vol. 66   page: 181-189   1994

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  392. 視覚テスト

    山田清文、鍋島俊隆

    生体の科学   Vol. 45   page: 484-485   1994

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  393. 聴覚テスト

    山田清文、鍋島俊隆

    生体の科学   Vol. 45   page: 482-483   1994

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  394. Resperidone prevents the development of super-sensitivity, but not tolerance, to phencyclidine in rats treated with subacute phencyclidine. Reviewed

    Kitaichi K, Yamada K, Yoneda Y, Ogita K, Hasegawa T, Furukawa H and Nabeshima T

    Life Sci.   Vol. 56   page: 531-543   1994

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  395. Changes in muscarinic cholinergic, PCP, GABAA, D1 and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats. Reviewed

    Nabehsima T, Yamada K, Hayashi T, Hasegawa T, Ishihara S, Kameyama T, Morimasa T, Kaneyuk T and Shohmori T

    Life Sci.   Vol. 55   page: 1585-1593   1994

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  396. Effects of Kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography : Changes in dopamine D1 and serotonin-5-HT2A receptor binding. Reviewed

    Ishihara S, Yamada K, Hayashi T, Hasegawa T, Kameyama T, Morimasa T, Kaneyuki T, Shohmori T and Nabeshima T

    Biol. Pharm. Bull.   Vol. 17   page: 1132-1134   1994

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  397. Effects of Kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by vitro autoradiography (1) Changes in the [3H]QNB binding. Reviewed

    Hayashi T, Yamada K, Hasegawa T, Ishihara S,Kameyama T, Morimasa T, Kaneyuki T, Shohmori T and Nabeshima T

    Jpn. J. Pharmacol.   Vol. 64   page: 303-306   1994

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  398. Oral administration of idevenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats. Reviewed

    Nitta A, Murakami Y, Furukawa Y, Kawatsura W, Hayashi K, Yamada K, Hasegawa T and Nabeshima T

    Naunyn-Schemiedeberg's Arch Pharmacol.   Vol. 349   page: 401-407   1994

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  399. ω-Conotoxin GVIA protects against ischemia-induced neuronal death in the Mongolian gerbil but not quinolinic acid-induced neurotoxicity in the rat. Reviewed

    Yamada K, Teraoka T, Seiji M, Hasegawa T and Nabeshima T

    Neuropharmacology   Vol. 33   page: 251-254   1994

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  400. The inhibitory effects of salmon calcitonin on intrathecally-injected N-methyl-D-aspartate-induced aversive behavior in mice. Reviewed

    Nabeshima T, Maeda Y, Yamada K, Nakamura T and Hasegawa T

    Res. Commun. Chem. Pathol. Pharmacol.   Vol. 82   page: 175-184   1993

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  401. Neuropharmacological characterization of voltage-sensitive calcium channels : Possible existence of neomycin-sensitive, ω-conotoxin GVIA-and dihydropyridines-resistant calcium channels in the rat brain. Reviewed

    Yamada K, Teraoka T, Seiji M, Hasegawa T and Nabeshima T:

    Jpn J. Pharmacol.   Vol. 63   page: 423-432   1993

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  402. Neuroprotective and antiamnesic effects of NMDA antagonists.

    Yamada K and Nabeshima T

    Drug News Perspectives   Vol. 4   page: 524-529   1991

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  403. Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody. Reviewed

    Nabeshima T, Ogawa S, Yamada K, Ishimaru H, Fuji K, Kameyama T, Fukuta T, Takeuchi R and Hayashi K

    Res. Commun. Chem. Pathol. Pharmacol.   Vol. 74   page: 141-152   1991

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  404. [3H]Hemicholinium-3 binding in rats with status epilepticus induced by lithium and pilocarpine. Reviewed

    Yamada K, Saltarelli MD and Coyle JT

    Eur. J. Pharmacol.   Vol. 195   page: 395-397   1991

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  405. Effects of calmodulin antagonists on sodium-dependent high-affinity choline uptake. Reviewed

    Yamada K, Saltarelli MD and Coyle JT

    Brain. Res.   Vol. 542   page: 132-134   1991

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  406. Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle. Reviewed

    Yamada K, Nabeshima T and Kameyama T

    J. Pharmacobio-Dyn.   Vol. 14   page: 351-355   1991

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  407. Phospholipase A2 and [3H]hemicholinium-3 binding sites in rat brain : a potential second messenger role for fatty acids in the regulation of high-affinity choline uptake. Reviewed

    Saltarelli MD, Yamada K and Coyle JT

    J. Neurosci.   Vol. 10   page: 62-72   1990

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  408. Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats. Reviewed

    Yamada K, Fuji K, Nabeshima T and Kameyama T

    Neurosci. Lett.   Vol. 118   page: 128-131   1990

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  409. Specificity of the activation of [3H]hemicholinium-3 binding by phospholipase A2. Reviewed

    Yamada K, Saltarelli MD and Coyle JT

    J. Pharmacol. Exp. Ther.   Vol. 249   page: 836-842   1989

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  410. 7-[3-(4-[2,3-dimethylphenyl]piperazinyl)propoxy]-2(1H)-qinolinone(OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor agonist. Reviewed

    Yasuda Y, Kikuchi K, Suzuki S, Tsutsui M, Yamada K and Hiyama T

    Life Sci.   Vol. 42   page: 1941-1954   1988

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  411. Involvement of phospholipase A2 in the regulation of [3H]hemicholimium-3 binding. Reviewed

    Yamada K, Saltarelli MD and Coyle JT

    Biochem. Pharmacol.   Vol. 37   page: 4367-4373   1988

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  412. Solubilization and characterization of a [3H]hemicholinium-3 binding site in rat brain. Reviewed

    Yamada K, Saltarelli MD and Coyle JT

    J. Neurochem.   Vol. 50   page: 1759-1764   1988

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  413. 電気ショックによる行動変化と脳内オピオイド受容体

    鍋島俊隆、松野 聖、山田清文、亀山 勉

      Vol. 11   page: 132-146   1985

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  414. Differences of alteration in opioid systems induced by conditioned suppression and electric footshock in mice. Reviewed

    Kameyama T, Nabeshima T and Yamada K

    Pharmacol. Biochem. Behav.   Vol. 22   page: 249-254   1985

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  415. Effects of antidepressant drugs on a quickly-learned conditioned suppression in mice. Reviewed

    Kameyama T, Nagasaka M and Yamada K

    Neuropharmacology   Vol. 24   page: 285-290   1985

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  416. 条件抑制におけるdopamineおよびopioid神経系の役割

    生物学的精神医学 最近の進歩   Vol. 1   page: 186-195   1985

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  417. Sex-dependent differences in the pharmacological actions and pharmacokinetics of phencyclidine in rats Reviewed

    Nabeshima T, Yamaguchi K, Yamada K, Hiramatsu M, Furukawa H and Kameyama T

    Eur. J. Pharmacol.   Vol. 97   page: 217-227   1984

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  418. Effects of opiate agonists on the conditioned suppression in motility of mice. Reviewed

    Nabeshima T, Yamada K and Kameyama T

    Neurosci. Lett.   Vol. 39   page: 301-306   1983

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  419. Effects of lesions in the striatum, nucleus accumbens and medial raphe on phencyclidine-induced stereotyped behaviors and hyperactivity in rats. Reviewed

    Nabeshima T, Yamada K, Yamaguchi K, Hiramatsu M, Furukawa H and Kameyama T

    Eur. J. Pharmacol.   Vol. 91   page: 455-462   1983

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  420. Contribution of different opioid systems on foot-shock-induced analgesia and motor suppression. Reviewed

    Nabeshima T, Yamada K and Kameyama T

    Eur. J. Pharmacol.   Vol. 92   page: 199-205   1983

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  421. Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum. Reviewed

    Nabeshima T, Yamaguchi K, Yamada K, Hiramatsu M, Furukawa H and Kameyama T

    Eur. J. Pharmacol.   Vol. 93   page: 229-234   1983

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Books 32

  1. 実践行動薬理学 第一編 基礎編:行動薬理研究における実験技術, 9.記憶・学習行動の評価法

    田熊一敞,山田清文( Role: Joint author)

    金芳堂  2010.3 

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    Language:Japanese

  2. 実践行動薬理学 第Ⅱ編 応用編:行動薬理研究の実際, 第4章 報酬機構関連, 3.依存性薬物による精神障害の分子機序

    永井拓,鍋島俊隆,山田清文( Role: Joint author)

    金芳堂  2010.3 

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    Language:Japanese

  3. 臨床精神薬理ハンドブック第2版 第3章・精神薬理学の研究手法

    監修 樋口輝彦,小山司 編集,神庭重信,大森哲郎,加藤忠史( Role: Joint author)

    医学書院  2009.12 

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    Language:Japanese

  4. 「病気と薬パーフェクトブック2009 薬局2009年3月増刊号(Vol.60, No.4)/ 24悪性腫瘍 脳腫瘍

    横田千津子,池田宇一,大越教夫監修,山田勝士,小高賢一,大井一弥,丸山徹,高村徳人,伊藤由紀編( Role: Joint author)

    南山堂  2009.3 

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  5. 綜合臨牀 2008年(Vol.57)増刊「新版処方計画法」・薬物依存症

    辻美江,石川和宏,野田裕幸,山田清文,田中聡,尾崎紀夫,鍋島俊隆( Role: Joint author)

    永井書店  2008.4 

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  6. スタンダード薬学シリーズ9、薬学と社会 第2版(日本薬学会編)・第8章 地域薬局の役割(SBO30-32)

    山田清文( Role: Joint author)

    東京化学同人  2008.3 

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    Language:Japanese

  7. Memory improvement, In: Encyclopedia of Neuroscience (C. Binder MD, Hirokawa N, Windhorst U, Hirsch MC, eds)

    Yamada K and Nabeshima T( Role: Joint author)

    Springer-Verlag Berlin and Heidelberg  2007 

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    Language:English

  8. 南山堂医学大辞典第19版・抗不安薬、催眠鎮静薬

    山田清文( Role: Joint author)

    南山堂  2006 

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  9. ストレスの事典(河野友信、石川俊男編)・基礎編第3章6節ストレスと行動

    山田清文、鍋島俊隆( Role: Joint author)

    浅倉書店  2005 

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  10. Molecular mechanism of amyloid-β-induced impairment of neurotransmission and memory in relation to oxidative stress, In: Recent Progress in Alzheimer’s and Parkinson’s Disease (Hanin I, Cacabelos R and Fisher A, eds)

    Yamada K, Kim HC and Nabeshima T( Role: Joint author)

    Taylor & Francis, London  2005 

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  11. 薬学生・実習指導者のための実務実習ガイドブック

    鍋島俊隆、榛葉哲男監修、山田清文、他23名編集( Role: Joint author)

    南山堂  2005 

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  12. クリニカルファーマシーのための疾病解析 第7版(福地 坦監訳)・第7章 生物工学

    山田清文、鍋島俊隆( Role: Joint author)

    医薬ジャーナル社  2005 

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  13. スタンダード薬学シリーズ9、薬学と社会(日本薬学会編)・第8章 地域薬局の役割(SBO30-32)

    山田清文( Role: Joint author)

    東京化学同人  2004.11 

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  14. Nitric oxide in learning and memory, In: From Messengers to Molecules: Memories are Made of These (Riedel, G., Platt, B., eds)

    Yamada K and Nabeshima( Role: Joint author)

    Landes Bioscience, Georgetown, Texas  2004 

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  15. Development of anti-dementia drugs for Alzheimer’s disease: present and future, In: Mapping the Progress of Alzheimer’s and Parkinson’s Disease (Mizuno Y, Fisher A, Hanin I, eds)

    Nabeshima T and Yamada, K( Role: Joint author)

    Kluwer Academic/Plenum Publishers, New York  2002 

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  16. Role of inducible nitric oxide synthase in β-amyloid-induced brain dysfunction in rats, In: Mapping the Progress of Alzheimer’s and Parkinson’s Disease (Mizuno Y, Fisher A, Hanin I, eds)

    Yamada K, Tran MH, Kim HC and Nabeshima T( Role: Joint author)

    Kluwer Academic/Plenum Publishers, New York  2002 

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  17. 非臨床試験マニュアル(野村護、堀井郁夫、吉田武美編)・第4 節モデル動物の利用と評価—脳—

    石川和宏、山田清文、鍋島俊隆( Role: Joint author)

    エル・アイ・シー  2001 

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  18. New therapeutic approaches to Alzheimer's disease, In Neuroscientific Basis of Dementia (C. Tanaka, P.L. McGeer and Y. Ihara, eds)

    Nabeshima T and Yamada K( Role: Joint author)

    Birkhäuser Verlag, Basel  2001 

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  19. 臨床精神医学講座「アルツハイマー病」(松下正明編)・新しい治療薬の開発

    鍋島俊隆、山田清文( Role: Joint author)

    中山書店  2000.6 

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  20. 咬合状態に起因する他臓器の異常(厚生科学研究「口腔保健と全身的な健康状態の関係について」運営協議会(座長:小林修平)編)・歯牙喪失による脳機能の変化―学習記憶およびアセチルコリン遊離の障害―

    山田清文、長谷川雅哉、加藤武司、上田 実、鍋島俊隆( Role: Joint author)

    財団法人口腔保健協会  2000 

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  21. 薬物治療学 第2版(南 勝、木皿憲佐編)・薬物療法での注意

    山田清文、鍋島俊隆( Role: Joint author)

    南山堂  2000 

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  22. クリニカルファーマシーのための疾病解析 第6版(福地 坦監訳)・第75章 免疫抑制患者における感染症

    山田清文、鍋島俊隆( Role: Joint author)

    医薬ジャーナル社  1999 

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  23. Nitric oxide production in vivo in the brain following a direct intrahippocampal injection of lipopolysaccharide in rats, In: The Biology of Nitric Oxide. Part 6. (Moncada S, Toda N, Maeda H and Higgs EA eds)

    ( Role: Joint author)

    Portland Press, U. K.  1998 

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    Language:English

  24. 神経伝達物質 update ―基礎から臨床まで 第3版(中村重信編)・拮抗物質

    山田清文、鍋島俊隆( Role: Joint author)

    中外医学社  1998 

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  25. Nitric oxide production caused by activation of non-N-methyl-D-aspartate and metabotropic glutamate receptors may be independent on nitric oxide synthase in the rat cerebellum in vivo, In: The Biology of Nitric Oxide. Part 6. (Moncada S, Toda N, Maeda H and Higgs EA eds)

    ( Role: Joint author)

    Portland Press, U. K.  1998 

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    Language:English

  26. 薬物治療学 初版(南 博、木皿憲佐著者代表)・薬物療法での注意

    山田清文、鍋島俊隆( Role: Joint author)

    南山堂  1997 

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    Language:Japanese

  27. レセプター分子薬理学的アプローチ 初版(日高弘義、谷口隆之、宇井理編)・中枢レセプターと行動

    山田清文、鍋島俊隆( Role: Joint author)

    講談社  1997 

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    Language:Japanese

  28. 神経行動薬理学研究の最前線―抗痴呆薬研究の最近の進歩―(小野寺憲治編)・学習記憶と伝達物質研究の進歩と最前線

    山田清文、鍋島俊隆( Role: Joint author)

    Prous Science,Spain  1997 

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  29. 医療薬学 新薬論 初版(金久保好男編)・向精神薬

    篠田正彦、山田清文、鍋島俊隆( Role: Joint author)

    広川書店  1995 

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  30. Memory impairment in rats induced by an active fragment of nerve growth factor antibody. In: Basic, clinical and therapeutic aspects of Alzheimer's and Parkinson's disease. Vol 1. (Nagatsu T et al., eds)

    ( Role: Joint author)

    Plenum Press, NY  1990 

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    Language:English

  31. 生物学的精神医学 最近の進歩 初版(難波益之編)・条件抑制におけるdopamine およびopioid 神経系の役割

    鍋島俊隆、亀井浩行、加藤 晃、長坂光昭、山田清文、亀山 勉( Role: Joint author)

    ヘスコインターナショナル  1985 

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  32. Sex differences in the pharmacological actions of phencyclidine in rats. In: Phencylcidine and related arylcyclohexylamines. Present and future applications. (J.M. Kamenka, E.F. Domino and P. Geneste, eds)

    ( Role: Joint author)

    NPP Books, Ann Arbor  1983 

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    Language:English

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Presentations 170

  1. 腎細胞癌患者におけるABCG2遺伝子多型のアキシチニブ血中濃度への影響

    加藤博史、山田清文

    第74回日本癌学会学術総会 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  2. 医薬連携を基盤とする名大病院・薬剤師外来

    山田 清文

    第17回応用薬理シンポジウム 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  3. プロテオミクス解析による新規IFITM3結合タンパク室の同定

    伊藤 教道、永井 拓、山田 清文

    第17回応用薬理シンポジウム 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  4. The insula controls decision-making in healthy and methamphetamine-treated rats. International conference

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  5. Correlation between the changes in body composition and anti-tumor effects or adverse events in chemotherapy for head and neck cancer.

    Yasutaka Fujino, Kazuki Imai, Koji Yano, Yasushi Fujimoto, Kiyofumi Yamada

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    Event date: 2015.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  6. 心房細動合併急性心不全入院患者における認知機能別にみた抗凝固療法導入状況の検討

    細川量代、奥村貴裕、渡邉直樹、小林聖典、清水美帆、山田清文、室原豊明

    第21回日本心臓リハビリテーション学会学術集会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  7. 肺がんEGFR阻害薬の皮膚障害マネジメントに対するチームの取り組み

    宮崎雅之、市川和哉、長谷哲也、山田里美、十九浦宏明、近藤征史、安藤雄一、長谷川好規、山田清文

    第13回日本臨床腫瘍学会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  8. 肺癌カルボプラチン併用療法の予防制吐治療失敗の検討

    市川和哉、森瀬昌宏、宮崎雅之、長谷哲也、近藤征史、長谷川好規、山田清文

    第13回日本臨床腫瘍学会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  9. UPLC-MS/MS定量法を用いたロピバカイン血中濃度測定の有用性

    宮崎雅之、永井拓、森厚詞、西脇公俊、山田清文

    第23回クリニカルファーマシーシンポジウム/医療薬学フォーラム2015 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  10. ニコチン投与は覚せい剤依存ラットの意志決定障害を緩解させる

    王天、溝口博之、山田清文

    第127回日本薬理学会近畿部会 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  11. 名古屋大学医学部附属病院老年内科における75歳以上の高齢者に対して特に慎重な投与を要する薬物のリスト該当薬物の使用状況

    渡邉雄貴、梅垣宏行、山田清文、葛谷雅文

    第57回日本老年医学会学術集会 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  12. 名古屋大学医学部附属病院老年内科入院期間中の薬剤の変更内容における病院・薬局間の情報共有強化とその有効性について

    渡邉雄貴、広瀬貴久、鈴木裕介、山田清文、葛谷雅文

    第57回日本老年医学会学術集会 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  13. Decision-making in animal models for neuropsychiatric. International conference

    IBNS 2015 Annual Meeting 

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    Event date: 2015.6

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Canada  

  14. Dysfunction of Gabaergic system in the insular cortex contributes to impairments of decision-making in methamphetamine-dependent rats. International conference

    Kiyofumi Yamada, Hiroyuki Mizoguchi

    ISAM2014 

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    Event date: 2014.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  15. Dysfunction of GABAergic system in the insular cortex is associated with impaired decision-making in methamphetamine-treated rats. International conference

    Kiyofumi Yamada, Kazuya Fukumoto, Tian Wang, Hiroyuki Mizoguchi

    29th CINP World Congress of Neuropsychopharmacology 

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    Event date: 2014.6

    Language:English   Presentation type:Poster presentation  

    Country:Canada  

  16. 精神疾患の病因仮説モデルを用いた創薬標的の探索研究

    山田清文

    日本薬学会 

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    Event date: 2014.3

    Language:Japanese  

    Venue:熊本県   Country:Japan  

  17. Dysfunction of GABAergic system in the insular cortex of an animal model for decision-making impairments.

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    Event date: 2014.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  18. 精神化領域における創薬研究の最前線~総合失調症を例として~

    山田清文

    日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2013 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:三重県   Country:Japan  

  19. ストレス応答性転写因子NPAS4欠損マウスにおけるGABA神経発達と表現方解析

    山田清文

    新学術領域「マイクロ精神病態」班会議 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  20. 薬物依存モデル動物の意思決定プロセスに対するニコチンの効果

    山田清文、溝口博之

    喫煙科学研究財団平成24年度助成研究発表会 

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    Event date: 2013.7

    Language:Japanese  

    Country:Japan  

  21. Animal model of treatment-resistant schizophrenia. International conference

    Kiyofumi Yamada, Daisuke Ibi, Akira Sawa, Taku Nagai

    28th CINP World Congress of Neuropsychopharmacology 

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    Event date: 2012.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  22. 脳神経発達障害の行動学的解析;周産期疑似ウィルス感染モデルを例として

    山田清文

    第23回産業神経・行動学研究会 

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  23. ベンゾジアゼピン系薬物の依存モデル International conference

    山田清文

    第107回日本精神神経学会学術総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京   Country:Japan  

  24. 災害支援医薬品活用システムの構築の必要性

    山田清文、曽良一郎、池田和隆、溝口広一

    第21回日本臨床神経精神薬理学会 第41回日本神経精神薬理学会合同年会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  25. ストレス応答性転写因子NPAS4の創薬標的としての可能性 International conference

    山田清文

    創薬薬理フォーラム 第19、回シンポジウム 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京   Country:Japan  

  26. 東日本大震災における緊急支援医薬品の活用状況と管理・供給上の問題点

    山田清文、曽良一郎、池田和隆、溝口広一、山脇成人

    医療薬学フォーラム2011 クリニカルファーマシーシンポジウム 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:旭川   Country:Japan  

  27. 新生仔期polyI:C処置によって誘発される不安様行動および学習記憶障害に対するニコチンの効果

    山田清文、Yu Jinghua、北原裕子、衣斐大祐、鍋島俊隆、永井拓

    第117回日本薬理学会近畿部会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  28. 望ましい薬剤師の生涯教育

    山田清文

    第60回日本病院学会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  29. Role of pallidotegmental gabaergic neurons in ppi of the acoustic startle reflex. International conference

    International Behavioral Neuroscience Society(IBNS) Annual Meeting 

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    Event date: 2010.6

    Language:English   Presentation type:Oral presentation (general)  

  30. Poly:C誘発神経発達障害動物モデルの行動異常とその発現機構

    愛知県心身障害者コロニー発達障害研究所 公開シンポジウム2009「自閉症・発達障害の基礎と臨床」 

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    Event date: 2009.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  31. 臨床卒業研究 臨床の視点から

    日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2009 

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    Event date: 2009.11

    Language:Japanese  

    Country:Japan  

  32. 神経発達障害仮説に基づく精神疾患動物モデル

    第2回「社会性認識」学際脳科学シンポジウム 

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    Event date: 2009.11

    Language:Japanese  

    Country:Japan  

  33. ニコチンのドパミン遊離作用におけるプロテアーゼシグナルの役割.

    山田清文,永井拓,溝口博之,鍋島俊隆

    財団法人喫煙科学研究財団第24回平成20年度助成研究発表会 

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    Event date: 2009.7

    Language:Japanese  

    Country:Japan  

  34. 大学病院薬剤部での実務と研究.

    愛知学院大学薬学会講演会 

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    Event date: 2009.6

    Language:Japanese  

    Country:Japan  

  35. 遺伝-環境相互作用に基づく統合失調症モデル

    第82回日本薬理学会年会 

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    Event date: 2009.3

    Language:Japanese  

    Country:Japan  

  36. 抗てんかん薬治療の基本と最近の話題

    愛知県病院薬剤師会学術講演会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  37. 食欲を刺激するホルモン“グレリン”の発見とその多彩な生理機能

    第82回日本薬理学会年会 

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    Event date: 2009.3

    Language:Japanese  

    Country:Japan  

  38. 長期隔離飼育および覚せい剤による脳特異的転写調節因子Npas4の発現変化.

    山田清文,Jaesuk YUN,衣斐大祐,日比陽子,新田淳美,永井拓

    第13回神経科学領域における分子モニタリングシンポジウム 

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    Event date: 2009.1

    Language:Japanese  

  39. 研究テーマB「脳とこころの病気」グループ.

    第13回神経科学領域における分子モニタリングシンポジウム 

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    Event date: 2009.1

    Language:Japanese  

    Country:Japan  

  40. Involvement of matrix metalloprotease-9 in cognitive impairment and neurotoxicity induced by i.c.v. injection of amyloid β protein in mice. International conference

    The 19th Korea-Japan Joint Seminar on Pharmacology 

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    Event date: 2008.11

    Language:English  

  41. がん専門薬剤師になるためのレクチャーシンポジウム「がん分子標的治療におけるがん専門薬剤師の役割

    山田清文,藤井聡

    第67回日本癌学会学術総会 

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    Event date: 2008.10

    Language:Japanese  

  42. メタンフェタミン依存マウスにおける薬物探索行動:GDNFの役割.(シンポジウム2「動物やヒトの行動に対する遺伝子・環境相互作用」)

    山田清文,鍋島俊隆

    第51回日本神経化学会 

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    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  43. 実務家教員に期待するもの‐大学病院の立場より‐(シンポジウム「薬学教育において実務家教員が果たすべき役割)

    第18回日本医療薬学会年会 

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    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  44. 実務家教員に期待するもの‐大学病院の立場より‐.(シンポジウム6「薬学教育において実務家教員が果たすべき役割」)

    第18回日本医療薬学会年会 

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    Event date: 2008.9

    Language:Japanese  

    Country:Japan  

  45. Alterations of Adult Neurogenesis in Animal Models for Schizophrenia: Role for NMDA Receptors. International conference

    2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP 

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    Event date: 2008.9

    Language:English  

    Country:Japan  

  46. Early life stress-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. International conference

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    Event date: 2008.9

    Language:English  

    Country:Japan  

  47. 薬物依存に関与するサイトカイン・プロテアーゼの動態および機能解析.(特別講演)

    第45回脳の医学・生物学研究会 

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    Event date: 2008.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  48. ニコチンのドパミン遊離作用におけるプロテアーゼシグナルの役割.

    山田清文, 永井拓, 田熊一敞, 溝口博之, 鍋島俊隆

    財団法人喫煙科学研究財団第23回平成19年度助成研究発表会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  49. アミロイドタンパクによる脳機能障害の分子機構.(特別講演)

    第3回東北薬科大学ハイテク・リサーチシンポジウム 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  50. 統合失調症‐薬物療法の現状から最先端研究まで‐(特別講演)

    石川県病院薬剤師会学術講演会 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  51. 遺伝子変異マウスを用いた薬物依存モデルの行動解析.(シンポジウム「精神疾患とその病態モデル小動物の表現型解析」)

    "山田清文, Yijin YAN, 永井拓, 溝口博之, 新田淳美, 鍋島俊隆

    第55回日本実験動物学会総会,第42回日本実験動物技術者協会総会合同大会(日本実験動物科学技術2008) 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  52. 学習記憶および情動の制御機構と障害に関する神経精神薬理学的研究.(平成20年度日本薬学会学術振興賞受賞講演)

    日本薬学会第128年会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  53. 精神科および神経科領域における疾病の薬物治療.

    石川県薬剤師会「薬局薬剤師グレードアップ講座」 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  54. tPA-プラスミンシステムによるニコチンの報酬効果の制御:PAR-1の関与.(シンポジウム「プロテイナーゼ活性化型受容体の基礎と臨床:新たな治療標的としての可能性を探る」)

    第81回日本薬理学会年会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  55. 学習記憶および情動に及ぼす発達期隔離ストレスの影響.

    山田清文, 衣斐大祐, 田熊一敞

    名城大学文部科学省学術フロンティア推進事業「脳とこころの発達における神経科学的・心理学的アプローチ」第1回研究成果報告会 

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    Event date: 2008.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  56. The role of tissue plasminogen activator in methamphetamine-induced reward, behavioral sensitization and cognitive deficit in mice. International conference

    Symposium of the Institute of Pharmaceutical Science 2007 

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    Event date: 2007.10

    Language:English  

  57. 覚せい剤による依存・精神病性障害と認知障害における組織プラスミノーゲン活性化因子の関与

    山田清文, 永井拓, 溝口博之, 鍋島俊隆, 田熊一敞

    第42回日本アルコール・薬物医学会総会、第19回日本アルコール精神医学会、第10回ニコチン・薬物依存研究フォーラム合同学術総会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  58. 発達障害のモデル動物作製と発症分子機序の解析

    山田清文

    第4回脳細胞・発達・学習・記憶分子シンポジウム 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  59. 統合失調症の認知障害モデル(シンポジウム「精神疾患治療の基礎から臨床へ」)

    山田清文, 田熊一敞, 溝口博之, 永井拓, 亀井浩行, 野田幸裕, 鍋島俊隆

    日本薬学会第127年会 

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    Event date: 2007.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  60. Cognitive dysfunction induced by chronic restraint stress in ovariectomized animals: an animal model of cognitive impairment in postmenopausal women. International conference

    The Korean Society for Gerontology 

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    Event date: 2006.10

    Language:English   Presentation type:Oral presentation (invited, special)  

  61. The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1(特別講演) International conference

    Special Lecture; College of Pharmacy Kangwon National University (Chunchon, KOREA) 

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    Event date: 2006.10

    Language:English   Presentation type:Oral presentation (invited, special)  

  62. Targeting the tPA-plasmin-protease activated receptor-1 system for the treatment of nicotine dependence. International conference

    18th Japan-Korea Joint Seminar on Pharmacology 

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    Event date: 2006.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  63. ニコチン依存におけるtPA-プラスミンシステムの役割

    山田清文, 永井拓, 伊藤美奈、中道範隆、亀井浩行, 深草亜由美, 鍋島俊隆, 田熊一敞

    第49回日本神経化学会大会 

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    Event date: 2006.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  64. Targeting the tPA-plasmin-protease activated receptor-1 system for the treatment of nicotine dependence. International conference

    18th Japan-Korea Joint Seminar on Pharmacology 

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    Event date: 2006.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  65. Regulation by tissue plasminogen activator-plasmin system of morphine reward by protease activated receptor-1. International conference

    The 2006 International Narcotic Research Conference 

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    Event date: 2006.7

    Language:English   Presentation type:Oral presentation (general)  

  66. ニコチンの神経精神作用における組織プラスミノーゲン活性化因子/プラスミンシグナルの役割.

    山田清文, 亀井浩行, 永井拓, 田熊一敞, 鍋島俊隆

    財団法人喫煙科学研究財団第21回平成17年度助成研究発表会 

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    Event date: 2006.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  67. The role of tissue plasminogen activator in methamphetamine-related reward and sensitization (Sympojium) International conference

    The American College of Neuropsychopharmacology (ACNP) 44th Annual Meeting 

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    Event date: 2005.12

    Language:English   Presentation type:Oral presentation (invited, special)  

  68. 薬物依存における組織プラスミノーゲン活性化因子の役割

    山田清文, 永井拓, 鍋島俊隆

    第27回日本生物学的精神医学会・第35回日本神経精神薬理合同年会 

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    Event date: 2005.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  69. ニコチンの神経精神作用における組織プラスミノーゲン活性化因子/プラスミンシグナルの役割.

    山田清文, 亀井浩行, 永井拓, 田熊一敞, 鍋島俊隆

    財団法人喫煙科学研究財団第20回平成16年度助成研究発表会 

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    Event date: 2005.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  70. Role of tPA in methamphetamine dependence and psychosis International conference

    8th World Congress of Biological Psychiatry. 

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    Event date: 2005.6

    Language:English   Presentation type:Oral presentation (invited, special)  

  71. Interaction of BDNF/TrkB signaling and NMDA receptors in spatial memory International conference

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    Event date: 2005.5

    Language:English   Presentation type:Oral presentation (invited, special)  

  72. Interaction of BDNF/TrkB signaling and NMDA receptors in spatial memory International conference

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    Event date: 2005.5

    Language:English   Presentation type:Oral presentation (invited, special)  

  73. 覚せい剤により誘発される認知障害

    山田清文, 亀井浩行, 永井拓, 中野寛子, 東岸由里子, 小林香奈, 田熊一敞, 鍋島俊隆

    第8回ニコチン・薬物依存研究フォーラム学術年会 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  74. 依存性薬物の報酬効果の神経機構に関する研究.

    山田清文, 永井拓, 亀井浩行, 田熊一敞, 鍋島俊隆

    文部科学省目標達成型脳科学研究「依存性薬物により誘発される精神障害の機構の解明の研究」平成16年度後期研究報告会 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  75. メタンフェタミン依存および神経毒性に対する内因性保護因子TNF-aの作用.

    山田清文, 中島晶, 永井拓, 宮本嘉明, 間宮隆吉, 水野誠, TRAN Manh Hung, 新田淳美, 北市清幸, 長谷川高明, 斉藤邦明, 清島満, KIM Hyoung Chun, 鍋島俊隆

    第8回ニコチン・薬物依存研究フォーラム学術年会 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  76. Involvement of tissue plasminogen activator-plasmin system in the modulation of depolarization-evoked dopamine release. International conference

    34th Annual meeting Society for Neuroscience 

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    Event date: 2004.10

    Language:English   Presentation type:Oral presentation (general)  

  77. Involvement of tissue plasminogen activator-plasmin system in the modulation of depolarization-evoked dopamine release. International conference

    34th Annual meeting Society for Neuroscience 

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    Event date: 2004.10

    Language:English   Presentation type:Oral presentation (general)  

  78. 少人数問題提起・解決型セミナー‐EBMに基づく標準的薬物療法について‐.

    山田清文, 犬飼舞, 小村江里, 白井良枝, 松尾亜伊, 山本将孝, 亀井浩行, 田熊一敞, 永井拓

    第14回日本医療薬学会 

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    Event date: 2004.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  79. 依存性薬物の報酬効果の神経機構に関する研究.

    山田清文, 田熊一敞, 亀井浩行, 永井拓, 鍋島俊隆

    文部科学省目標達成型脳科学研究「依存性薬物により誘発される精神障害の機構の解明の研究」平成16年度前期研究報告会 

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    Event date: 2004.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  80. 覚醒剤および麻薬依存に共通する依存関連分子の検索

    山田清文、永井 拓、新田淳美、鍋島俊隆

    薬理学セミナー2004 

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    Event date: 2004.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  81. 覚せい剤および麻薬依存に共通する内因性anti-addictiveおよびpro-addictive substances.(シンポジウム:薬物依存の分子機構)

    山田清文、鍋島俊隆

    第31回トキシコロジー学会学術年会 

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    Event date: 2004.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  82. The tissue plasminogen activator-plasmin system participates in morphine-induced dopamine-dependent behaviors by regulating dopamine release. International conference

    IIIrd Meeting of Asian Pacific Opioid Symposium on Molecular Basis of Opioid Tolerance and Dependence 

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    Event date: 2004.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  83. モルヒネの報酬効果における組織プラスミノーゲン活性化因子‐プラスミン系の関与(シンポジウム)

    山田清文、永井拓、Yan Yijin、亀井浩行、野田幸裕、新田淳美、鍋島俊隆

    第77回日本薬理学会年会 

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    Event date: 2004.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  84. 老年期痴呆の予防と治療(特別講演)

    山田清文

    三重県厚生連薬剤師学術講演会 

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    Event date: 2004.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  85. 老年期痴呆の予防と治療(学術講演)

    山田清文

    平成15年度薬剤師生涯教育推進事業 指導者研修会 

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    Event date: 2003.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  86. メタンフェタミンの弁別刺激効果に対するTNF-a抑制作用.

    山田清文, 中島晶, HE Jue, ZENG Nan, 新田淳美, 鍋島俊隆

    第104回日本薬理学会近畿部会 

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    Event date: 2003.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  87. Interaction of BDNF/TrkB Signaling and NMDA Receptors in Spatial Memory(セッションオーガナイザー) International conference

    The Ist Symposium Neurobehavioral Pharmacology 

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    Event date: 2003.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  88. Interaction of BDNF/TRKB signaling NMDA receptors in spatial memory. International conference

    1st Symposium of Neurobehavioral Pharmacology 

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    Event date: 2003.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  89. 少人数グループ学習形式による問題解決型学習:水・電解質,輸液の学習を通して.

    山田清文, 熊倉康郎, 坂口純子, 高橋紀子, 中川貴史, 橋詰岳, 亀井浩行

    第13回日本医療薬学会 

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    Event date: 2003.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  90. Amyloid b-peptide-induced brain dysfunction: Involvement of oxidative Stress, inducible nitric oxide synthase and protein tyrosine nitration. (セッションオーガナイザー) International conference

    The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists 

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    Event date: 2003.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  91. Amyloid b-peptide-induced brain dysfunction: involvement of oxidative stress, inducible nitric oxide synthase and protein tyrosine nitration. International conference

    The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists 

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    Event date: 2003.8

    Language:English   Presentation type:Oral presentation (general)  

  92. Klotho遺伝子変異マウスの行動解析(シンポジウム)

    山田清文、永井 拓、鍋島陽一、鍋島俊隆

    日本行動計量学会第31会大会 

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    Event date: 2003.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  93. Neuroprotective role of TNF-a in methamphetamine-indcued drug dependence and neurotoxicity(シンポジウム). International conference

    Satellite Meeting of the International Society for Neurochemistry and Asian Society for Neurochemistry 

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    Event date: 2003.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  94. Neuroprotective role of TNF-α in methamphetamine-induced drug dependence and neurotoxicity. International conference

    International Society for Neurochemistry/Asian Pacific Society for Neurochemistry Sponsored Satellite Meeting 

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    Event date: 2003.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  95. メタンフェタミン依存および神経毒性におけるTNF-αの役割(ワークショップ)

    山田清文、亀井浩行、中島 晶、新田淳美、鍋島俊隆

    第38回日本アルコール薬物医学会総会 

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    Event date: 2003.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  96. アルツハイマー病の薬物療法‐現状と将来‐(特別講演)

    山田清文

    PCファーラム三重 

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    Event date: 2003.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  97. メタンフェタミンとモルヒネ依存に共通する薬物依存関連因子の検索

    山田清文, 亀井浩行, 中島 晶, 永井 拓, 新田淳美, 鍋島俊隆

    日本薬学会第123回年会シンポジウム 

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    Event date: 2003.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  98. Molecular mechanism of brain dysfunction induced by amyloid b-peptide in vivo International conference

    The 4th ILSONG International Symposium on Aging and Neurodegenerative Diseases 

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    Event date: 2002.12

    Language:English   Presentation type:Oral presentation (invited, special)  

  99. アルツハイマー病治療薬の現状と展望

    山田清文

    薬剤師生涯教育リフレッシュフォーラム, 

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    Event date: 2002.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  100. b‐アミロイド蛋白により誘発されるシナプトフィジンのチロシンニトロ化.

    山田清文, Manh Hung Tran, 中島晶, 水野誠, 亀井浩行, 鍋島俊隆

    第75回日本薬理学会年会 

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    Event date: 2002.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  101. オピオイド系鎮痛薬と神経刺激薬に共通した薬物依存の形成機構.

    山田清文, 宮本嘉明, 水野誠, Jue He, 中島晶, 永井拓, 溝口博之, 内山武久, 吉村正子, 水野朋子, 石川和宏, 野田幸裕, 鍋島俊隆

    科学技術振興調整費目標達成脳科学研究「依存性薬物により誘発される精神障害の機構の解明の研究」平成13年度班会議 

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    Event date: 2002.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  102. 学習記憶におけるBDNFの役割(シンポジウム)

    山田清文、水野 誠、鍋島俊隆

    第31回日本神経精神薬理学会 

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    Event date: 2001.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  103. メタンフェタミンの精神依存および神経毒性におけるTNF-αの役割(シンポジウム)

    山田清文、中島 晶、内山武久、石川和宏、鍋島俊隆

    第24回日本神経科学、第44回日本神経化学 (Neuro2001) 

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    Event date: 2001.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  104. 学習記憶におけるNO/BDNFシグナルの役割.

    山田清文, 水野誠, 鍋島俊隆

    第7回日本行動薬理研究会 

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    Event date: 2001.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  105. メタンフェタミンの条件性場所嗜好反応の発現に伴うmitogen-activated protein kinases (MAPK) の活性化.

    山田清文, 水野誠, 溝口博之, 宮本嘉明, 鍋島俊隆

    第4回ニコチン・薬物依存研究フォーラム学術年会 

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    Event date: 2001.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  106. β?アミロイド蛋白により誘発される脳機能障害:抗痴呆薬開発への応用(招待講演)

    山田清文、鍋島俊隆

    第19回生物製剤学研究会 

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    Event date: 2001.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  107. b-アミロイド蛋白により誘発される脳機能障害における誘導型一酸化炭素合成窒素の関与.

    山田清文, Tran MH, 鍋島俊隆

    第28回日本脳科学会 

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    Event date: 2001.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  108. ラット脳室内へのb-アミロイド蛋白の持続注入により誘発されるprotein kinase Cの変化.

    山田清文, Olariu A, 鍋島俊隆

    第23回日本生物学的精神医学会 

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    Event date: 2001.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  109. Non-transgenic models of Alzheimer's disease: animal model of Alzheimer's disease induced by continuous infusion of b-amyloid protein (シンポジウム) International conference

    5th International Conference on Progress in Alzheimer's and Parkinson's Disease. 

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    Event date: 2001.3

    Language:English   Presentation type:Oral presentation (invited, special)  

  110. Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular gluthathione levels. International conference

    31th Meeting of Society for Neuroscience 

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    Event date: 2001

    Language:English   Presentation type:Oral presentation (general)  

  111. 老化促進マウス(Klothoマウス)の脳機能解析.

    山田清文, 永井拓, 鍋島陽一, 鍋島俊隆

    平成12年度文部省科学研究費補助金特定領域研究 (C)「先端脳」班会議 

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    Event date: 2000.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  112. Involvement of BDNF in spatial learning and memory in a radial arm maze test in rats. International conference

    30th Meeting of Society for Neuroscience 

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    Event date: 2000.11

    Language:English   Presentation type:Oral presentation (general)  

  113. A role of c-Fos expression and BDNF for spatial memory formation in rats(特別講演) International conference

    Special Lecture; College of Pharmacy Kangwon National University (Chunchon, KOREA) 

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    Event date: 2000.10

    Language:English   Presentation type:Oral presentation (invited, special)  

  114. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. International conference

    The 15th Korea-Japan Joint Seminar on Pharmacology 

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    Event date: 2000.10

    Language:English   Presentation type:Oral presentation (general)  

  115. 八方向型放射状迷路を用いた報酬位置変動式学習記憶試験とその特徴- (1) 行動薬理学的検討.

    山田清文, Jue He, 鍋島俊隆

    第30回日本神経精神薬理学会年会 

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    Event date: 2000.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  116. ノシセプチン受容体欠損マウスの学習記憶亢進の機序(シンポジウム)

    山田清文、間宮隆吉、宮本嘉明、野田幸裕、竹島 浩、鍋島俊隆

    第23回日本神経科学大会、第10回日本神経回路学会合同大会 

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    Event date: 2000.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  117. TNF欠損マウスの情動行動の変化.

    山田清文, 飯田竜一, 宮本嘉明, 齋藤邦明, 清島満, 鍋島俊隆

    第23回日本神経科学大会第10回日本神経回路学会合同大会 

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    Event date: 2000.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  118. β―アミロイド注入による痴呆モデルに対する抗酸化剤の効果(シンポジウム)

    山田清文

    第3回「Vitamin E Up Data Forum」 

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    Event date: 2000.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  119. 学習記憶におけるノシセプチンの役割―ノシセプチン受容体欠損マウスを用いた研究―(シンポジウム)

    山田清文、間宮隆吉、宮本嘉明、野田幸裕、竹島 浩、鍋島俊隆

    第21回鎮痛薬・オピオイドペプチドシンポジウム 

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    Event date: 2000.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  120. Involvement of BDNF in spatial learning and memory in a radial arm maze task in rats.

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    Event date: 2000.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  121. ノシセプチン受容体遺伝子ノックアウトマウスの学習記憶の増強の神経機構.

    山田清文, 間宮隆吉, 宮本嘉明, Olariu Ana, 野田幸裕, 竹島浩, 鍋島俊隆

    第9回神経行動薬理若手研究者の集い 

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    Event date: 2000.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  122. Involvement of nitric oxide in pentylenetetrazol-induced kindling in rats. International conference

    29th Meeting of Society for Neuroscience 

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    Event date: 1999.10

    Language:English   Presentation type:Oral presentation (general)  

  123. Effect of ovariectomy on b-amyloid-induced memory deficits in rats. International conference

    International Symposium on Dementia 

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    Event date: 1999.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  124. 合成βーアミロイド蛋白による学習障害(シンポジウム)

    山田清文、鍋島俊隆

    第5回行動薬理研究会 

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    Event date: 1999.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  125. 歯牙喪失による脳機能の変化?行動解析とin vivo dialysis 法による評価?(ワークショップ)

    山田清文

    厚生科学研究「口腔保健と全身的な健康状態の関係」(主任研究者:小林修平)研究協力者会議(葉山ワークショップ) 

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    Event date: 1999.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  126. ペンチレンテトラゾール誘発キンドリングにおける一酸化窒素の関与.

    山田清文, 韓大建, 千崎康司, Huabaio Xiong, 那波宏之, 鍋島俊隆

    第22回日本神経科学大会 

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    Event date: 1999.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  127. 日本における抗痴呆薬開発の現状(シンポジウム)

    山田清文、鍋島俊隆

    第8回神経行動薬理若手研究者の集い 

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    Event date: 1999.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  128. Ovariectomy potentiates b-amyloid-induced working memory deficits in rats.

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    Event date: 1999.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  129. b-アミロイド蛋白により誘発されるラットの学習記憶障害に対するネフィラセタムの改善作用.

    山田清文, 田中智子, 亀山勉, 鍋島俊隆

    第28回日本神経精神薬理学会 

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    Event date: 1998.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  130. ラット脳室内へのb-アミロイド蛋白の持続注入により誘発される海馬のBDNF mRNAの増加.

    山田清文, 唐亜平, 加納安彦, 宮崎高志, 村田善晴, 妹尾久雄, 鍋島俊隆

    第21回日本神経科学・第41回日本神経化学合同大会 

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    Event date: 1998.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  131. bアミロイド蛋白(1-42)の脳室内持続注入により誘発されるラットの学習記憶障害に対する抗酸化剤の作用.

    山田清文, 田中智子, 韓大健, 千崎康司, 亀山勉, 鍋島俊隆

    第93回日本薬理学会近畿部会 

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    Event date: 1998.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  132. Brain dysfunction associated with an induction of nitric oxide synthase following an intracerebral injection of lipopolysaccharide in rats.

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    Event date: 1998.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  133. Modulation of [3H]hemicholinium-3 binding sites and high-affinity choline uptake by unsaturated free fatty acids. International conference

    The 7th Meeting of European Society for Neurochemistry 

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    Event date: 1998

    Language:English   Presentation type:Oral presentation (general)  

  134. Solubilization and characterization of a [3H]hemicholinium-3 binding site. International conference

    The19th Meetingof American Society for Neurochemistry 

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    Event date: 1998

    Language:English   Presentation type:Oral presentation (general)  

  135. 脳内のNO 産生の調節機構を研究する上でのNOx 測定の問題点について(テクニカルセミナー)

    山田清文、鍋島俊隆

    第40回日本神経化学会 

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    Event date: 1997.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  136. ラットの放射状迷路学習に対する神経型一酸化窒素合成酵素阻害剤 7-nitroindazole の作用.

    山田清文, 鄒莉波, 田中智子, 亀山勉, 鍋島俊隆

    第27回日本神経精神薬理学会年会 

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    Event date: 1997.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  137. Nitric oxide production in vivo in the brain following a direct intrahippocampal injection of lipopolysaccharide in rats. International conference

    The 5th International Meeting on the Biology of Nitric Oxide 

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    Event date: 1997.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  138. ダイノルフィンフラグメントによる抗痴呆薬の開発のための基礎的研究‐脳内での一酸化窒素(NO)の産生調節に関する検討.

    山田清文, 鍋島俊隆

    平成7-8年度文部省科学研究費基盤研究B試験1研究成果報告会 

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    Event date: 1997.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  139. 学習記憶過程における一酸化窒素の役割に関する研究(学術奨励賞受賞講演)

    山田清文

    第70日本薬理学会年会 

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    Event date: 1997.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  140. Effects of NG-nitro-L-arginine methyl ester (L-NAME) and cytochrome P-450 inhibitors on glutamate receptor agonist-induced increase in nitric oxide metabolite levels in the rat cerebellum in vivo.

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    Event date: 1997.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  141. 神経細胞死に対するインターロイキン‐6の保護作用.

    山田清文, 鍋島俊隆, 梅垣宏行, 井口昭久

    第1回東海アポトーシス研究会 

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    Event date: 1997.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  142. Nitric oxide in the brain: modulation of production and the role in learning and memory International conference

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    Event date: 1997

    Language:English   Presentation type:Oral presentation (invited, special)  

  143. In vivo microdialysis 法を用いたラット脳内の一酸化窒素代謝物の測定(特別講演)

    山田清文、鍋島俊隆

    第7回マイクロダイアリシス研究会 

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    Event date: 1996.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  144. ラット小脳における一酸化窒素(NO)産生に対するグルタミン酸レセプターアゴニストの作用.

    山田清文, 鍋島俊隆

    第26回日本神経精神薬理学会年会 

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    Event date: 1996.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  145. ラット小脳での一酸化窒素(NO)産生におけるグリア細胞の役割.

    山田清文, 鍋島俊隆

    第39回日本神経化学会 

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    Event date: 1996.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  146. ラット小脳における一酸化窒素産生の調節メカニズムについて

    山田清文、鍋島俊隆

    第1回神経科学領域における分子モニタリングシンポジウム 

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    Event date: 1996.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  147. 学習記憶過程における一酸化窒素の役割とメカニズム.

    山田清文, 野田幸裕, 鍋島俊隆

    第2回行動薬理研究会ならびに神経行動薬理若手研究者の集い5周年記念シンポジウム 

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    Event date: 1996.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  148. Measurement of nitrite and nitirate in the cerebellum of awake rats by using in vivo brain microdialysis.

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    Event date: 1996.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  149. Neuroprotective effects of interleukin-6 in PC12 cells. International conference

    The 5th International Conference on Alzheimer's Disease and Related Diseases 

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    Event date: 1996.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  150. In vivo brain microdialysis法を用いたラット小脳における一酸化窒素代謝物の測定.

    山田清文, 鍋島俊隆

    第89回日本薬理学会近畿部会 

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    Event date: 1996.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  151. In vivo brain microdialysis法によるラット小脳におけるNO代謝物の測定.

    山田清文, 鍋島俊隆

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    Event date: 1996.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  152. MK-801により誘発されるマウスの自発交替行動障害におけるNO/cyclic GMP系の役割.

    山田清文,野田幸裕,間宮隆吉,平松正行,村井正明,亀山 勉,小森由美子,二改俊章,杉原久義,鍋島俊隆

    第69回日本薬理学会年会 

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    Event date: 1996.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  153. 6-Hydroxydopamineの細胞毒性に対するサイトカインおよび神経栄養因子の保護作用.

    山田清文, 熊小莉, 服部貴代美, 梅垣宏行, 井口昭久, 鍋島俊隆

    第88回日本薬理学会近畿部会 

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    Event date: 1995.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  154. Dizocilpine(MK-801)誘発健忘におけるNO/cGMPの役割.

    山田清文, 野田幸裕, 鍋島俊隆

    第25回日本神経精神薬理学会年会 

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    Event date: 1995.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  155. Orally active NGF synthsis stimulator as a potential candidate of therapeutic agent to Alzheimer's disease. International conference

    The 15th ISN Satellite Symposium ""Neurochemical and Psychopharmacological Approaches to Cognitive Enhancers" 

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    Event date: 1995.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  156. Phencyclidine誘発行動の耐性および逆耐性発現における一酸化窒素の関与.

    山田清文, 野田幸裕, 鍋島俊隆

    第38回日本神経化学会 

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    Event date: 1995.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  157. Orally active NGF synthsis stimulator as a potential candidate of therapeutic agent to Alzheimer's disease. International conference

    The15th ISN Satellite Symposium “Neurochemical and Psychopharmacological Approaches to Cognitive Enhancers" 

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    Event date: 1995.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  158. A role of nitric oxide in spatial learning of radial arm maze task in rats.

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    Event date: 1995.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  159. The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice. International conference

    The 25th Meeting of Society for Neuroscience 

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    Event date: 1995

    Language:English   Presentation type:Oral presentation (general)  

  160. ラットの学習行動に対する一酸化窒素合成酵素阻害剤の作用.

    山田清文, 野田幸裕, 長谷川高明, 鍋島俊隆

    第18回日本神経科学会 

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    Event date: 1994.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  161. 老齢ラット脳における一酸化窒素合成酵素含有神経細胞の減少.

    山田清文, 野田幸裕, 鍋島俊隆

    第37回日本神経化学会 

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    Event date: 1994.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  162. Behavioral and Neurochemical evidences that ω- conotoxin GVIA inhibits the striatal dopamine release in vivo.

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    Event date: 1993.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  163. ラット脳内neomycin感受性カルシウムチャンネルの特徴について.

    山田清文, 寺岡友美, 森田誠治, 長谷川高明, 鍋島俊隆

    第84回日本薬理学会近畿部会 

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    Event date: 1993.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  164. Specific activation of [3H]hemicholinium-3 binding in rat synaptic membranes by phospholipase A2. International conference

    The 18th Meeting of Society for Neuroscience 

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    Event date: 1988

    Language:English   Presentation type:Oral presentation (general)  

  165. 電気ショックにより誘発される鎮痛及び行動抑制とオピエートシステムの関係.

    山田清文, 鍋島俊隆, 亀山勉

    第56回日本薬理学会総会 

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    Event date: 1983.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  166. Phencyclidineにより誘発される常同行動に対する脳諸部位破壊の影響.

    山田清文, 平松正行, 山口和政, 鍋島俊隆, 古川宏, 亀山勉

    第6回日本薬理学会近畿西南合同部会 

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    Event date: 1982.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  167. 条件抑制に対するopiate agonist及びantagonistの影響.

    山田清文, 鍋島俊隆, 亀山勉

    第9回脳研究会 

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    Event date: 1982.10

    Language:Japanese  

  168. マウスのストレスによる行動抑制について.

    山田清文, 鍋島俊隆, 亀山勉

    日本動物心理学会第42回大会 

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    Event date: 1982.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  169. 電気ショックおよび条件抑制によるマウスの行動量減少とオピエート神経系の関連.

    山田清文, 鍋島俊隆, 亀山勉

    第61回日本薬理学会近畿部会 

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    Event date: 1982.6

    Language:Japanese  

    Country:Japan  

  170. 条件抑制に対するmorphine様物質の作用.

    山田清文, 鍋島俊隆, 亀山勉

    第4回中部日本神経精神薬理学研究会 

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    Event date: 1982

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

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Works 17

  1. 新しい抗精神病薬の開発を目指したトランスレーショナルリサーチの推進.薬事日報. 2011.3.18

    2011

  2. 抗うつ薬の使い方. 薬事日報. 2010.9.10

    2010

  3. 地域医療と研究教育への貢献を両立させる大学病院薬剤部(Interview)Sound Sleep Pharma, 3, 2009.2

    2009

  4. 医療を考える「薬学教育6年制に思う」・薬事新報・2587,3・2009,7.16

    2009

  5. 会社勤め.[懐かしき日々]. 名大医学部学友時報, 711, 2009.4.22

    2009

  6. 抗精神病薬の使い方. 薬事日報, 10650, 6-7, 2009.2.27

    2009

  7. 薬物依存の分子機構(研究トピックス):名大医学部学友時報, 694(2007.11.22)

    2007

  8. 外用抗生物質の院内製剤方法(質疑応答):日本医事新報, 4414 (2008.11.29)

    2007

  9. 薬剤誘発性睡眠障害:薬事日報(2008.10.6)

    2007

  10. 精神科専門薬剤師認定制度:薬事日報(2008.10.1)

    2007

  11. 薬物の「快感酵素」特定:北陸中日新聞 (2005.2.12)

    2002

  12. ドーパミンD1受容体・ERK1/2シグナル-活性化が長期認知記憶に関与:Medical Tribune (2007.6.7)

    2002

  13. ニコチン依存症治療に光:北陸中日新聞 (2006.12.01)

    2002

  14. 学術の森「依存症の犯人補足」:北國新聞 (2005.6.21)

    2002

  15. Philip J. Schneider, 全田浩, 鍋島俊隆, 岩本喜久生, 大石了三, 岡田啓, 木平健治, 宮崎勝巳, 山田清文:「アメリカでの薬剤師の教育・研修」についての座談会.日本病院薬剤師会雑誌, 36, 1619-1629, 2000

    1993

  16. 学習記憶過程における一酸化窒素の役割に関する研究. Medical Academy News, 650, 8, 1997

    1993

  17. NGFの産生を促進する薬剤について. FAX・DIニュース(医薬情報社), 119, 1, 1996

    1993

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Research Project for Joint Research, Competitive Funding, etc. 28

  1. ARHGAP10変異を伴う精神疾患の薬効及び副作用評価系の構築、並びに治療薬候補化合物の探索

    2020.4

    共同研究 

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    Authorship:Coinvestigator(s) 

    Grant amount:\2500000 ( Direct Cost: \2500000 )

  2. 全身性免疫応答に連関する中枢グリア細胞の機能変化

    2018.1 - 2020.3

    第10回 特定研究助成金 

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    Grant type:Competitive

  3. 神経発達障害モデルにおけるセクレトーム解析

    2013.10 - 2014.3

    企業からの受託研究 

  4. 創薬標的としてのニコチン受容体:覚せい剤依存モデル動物の近視眼的意思決定に対するニコチン効果

    2013.4 - 2016.3

    喫煙科学研究財団 

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    Grant type:Competitive

  5. 薬物依存モデル動物の意思決定プロセスに対するニコチンの効果

    2012.4 - 2013.3

    喫煙科学研究財団 

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    Grant type:Competitive

  6. 総合失調症モデルマウスの研究

    2009.7 - 2011.5

    企業からの受託研究 

  7. Effects of rivastigmine on amyloid-induced memory impairment: involvement of NO-mediated mechanisms

    2008.6 - 2010.6

    Funded Research from Enterprise 

  8. 統合失調症モデルマウスの研究

    2008.6 - 2010.5

    企業からの受託研究 

  9. 神経疾患・腫瘍の統合分子医学の拠点形成

    2008.4 - 2013.3

    学内共同研究 

  10. ニコチンのドパミン遊離作用におけるプロテアーゼシグナルの役割

    2008.4 - 2011.3

    (財)喫煙科学研究財団(特定研究) 

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    Grant type:Competitive

    ニコチンによるドーパミン放出における組織プラスミノーゲン活性化因子の役割に関する研究

  11. ストレスセンサーとしての脳特異的転写調節因子Npas4の動態および機能解析

    2008 - 2010.3

    武田科学研究奨励財団 

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    Grant type:Competitive

  12. Mechanism of cognitive impairment in a neurodevelopmental animal model of schizophrenia.

    2007.4 - 2008.3

    Cooperative Research within Japan 

  13. 神経発達関連因子を標的とした統合失調症の分子病態解明

    2007.4

    国内共同研究 

  14. プロテアーゼ活性化受容体を分子標的とした禁煙補助薬・依存症治療薬の開発に関する研究の発展

    2006.4 - 2007.3

    三谷研究開発支援財団 

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    Grant type:Competitive

  15. 分泌型セリンプロテアーゼ/プロテアーゼ受容体を分子標的とした禁煙補助薬・依存症治療薬の開発に関する基礎的研究

    2005.4 - 2006.3

    三谷研究開発支援財団 

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    Grant type:Competitive

  16. 薬物依存における分泌型セリンプロテアーゼ/プロテアーゼ活性化受容体の役割

    2005.4 - 2006.3

    先進医薬振興財団 

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    Grant type:Competitive

  17. 発達・学習・記憶と障害の革新脳科学の創成

    2004.4 - 2007.3

    国内共同研究 

  18. ニコチンの神経精神作用における組織プラスミノーゲン活性化因子/プラスミンシグナルの役割

    2004.4 - 2006.3

    (財)喫煙科学研究財団 

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    Grant type:Competitive

    ニコチンの報酬効果における組織プラスミノーゲン活性化因子の役割に関する基礎研究

  19. 神経精神疾患における組織プラスミノーゲン活性化因子の役割の解明

    2003.4 - 2004.3

    (財)医薬資源研究振興会 研究助成金 

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    Grant type:Competitive

  20. 薬物依存形成における免疫系サイトカインTNF-αの役割

    2002.4 - 2003.3

    財団法人ノバルティス科学振興財団:第16回ノバルティス研究奨励金 

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    Grant type:Competitive

  21. 生体複雑系の4次元分子論的解析と臨床医学・教育への応用(分担課題:ニューロトロフィン・サイトカインによる高次精神機能の制御と破綻)

    2001.4 - 2002.3

    学内共同研究 

  22. 依存性薬物により誘発される精神障害の機構の解明の研究(分担課題:オピオイド系鎮痛薬と精神刺激薬に共通した薬物依存の形成機構)

    2000.4 - 2002.3

    国内共同研究 

  23. 学習記憶におけるニューロトロフィンとその受容体の役割

    1999.4 - 2000.3

    (財)薬理研究会研究助成 

      More details

    Grant type:Competitive

  24. β-アミロイド蛋白により誘発される学習記憶障害の発現機序

    1998.4 - 1999.3

    (財)薬学研究奨励財団研究助成金 

      More details

    Grant type:Competitive

  25. ラット脳室内へのβ-アミロイド蛋白の持続注入により誘発される学習記憶障害の発現機序

    1998.4 - 1999.3

    鈴木謙三記念(財)医科学応用研究財団調査研究助成金 

      More details

    Grant type:Competitive

  26. 第26回米国神経科学会への出席

    1996

    (財)金原一郎医学医療振興財団研究交流助成金 

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    Grant type:Competitive

  27. 学習記憶過程におけるガス状情報伝達物質一酸化窒素 (NO) の役割の解明

    1994.4 - 1996.3

    石田財団研究助成 

      More details

    Grant type:Competitive

  28. サイトカインの神経保護作用に関する研究

    1994.4 - 1995.3

    (財)臨床薬理研究振興財団研究助成金 

      More details

    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 18

  1. Genomic analysis-based neuropharmacological study on basal ganglia-thalamocortical circuits for new drug discovery in schizophrenia

    Grant number:20H03428  2020.4 - 2023.3

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    Authorship:Principal investigator 

    Grant amount:\7540000 ( Direct Cost: \5800000 、 Indirect Cost:\1740000 )

  2. Development a translatable visual discrimination test in rodents to apply for drug discovery and development

    Grant number:17H04031  2017.4 - 2020.3

    Yamada Kiyofumi

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    Authorship:Principal investigator 

    Grant amount:\17940000 ( Direct Cost: \13800000 、 Indirect Cost:\4140000 )

    Cognitive function in mouse models of schizophrenia was evaluated by a touchscreen-based visual discrimination (VD) test, a rational assay that can be performed by rodents and humans, in order to provide translational validity. Genetic mouse models of schizophrenia, including mouse carrying DISC1 deletion, schizophrenia-associated RELN or ARHGAP10 gene mutation, all exhibited impairments in the VD test, which was accompanied by an increase in c-Fos expression in the prefrontal cortex and dorsomedial striatum. We also demonstrated that mitogen-activated protein kinase signaling in the dopamine D1 receptor expressing-medium spiny neurons of the nucleus accumbens plays an important role in stimulus-reward learning. Through the comprehensive behavioral and neurochemical analyses of genetic mouse models of neuropsychiatric disorders we have identified several new targets for novel drug discovery and development.

  3. Development of a new transgenic mouse model as a platform for the imaging-based drug discovery and development

    Grant number:16K15201  2016.4 - 2018.3

    Yamada Kiyofumi

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    Authorship:Principal investigator 

    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    In 2016, to regulate the expression of target genes in a neuronal activity-dependent manner, we created a new transgenic mice line (NPAS4-tTA mice) in which the expression of tTA gene is regulated under the control of Npas4 promoter. We obtained the double transgenic mice following mating with tet0-ChR2-EYFP transgenic mice as a reporter. The double transgenic mice exhibited a high background expression of EYFP in the brain with or without pentylentetrazole (PTZ) treatment.
    In 2017, we prepared cyclic AMP response element (CRE)-luciferase expression system using AAV vector. We observed a significant increase in chemiluminescent after cocaine treatment in vivo in the brain of mice expressing the CRE-luciferase gene. As to the functional analysis of target genes of Npas4, we demonstrated that Npas4-Homer1a signal played a role in the regulation of homeostatic scaling in the hippocampus.

  4. 意思決定の神経回路・分子機構の解明と創薬研究への応用

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(B),課題番号26293053

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    Authorship:Principal investigator 

  5. 過剰免除反応による精神疾患発症機構のリアルタイムイメージング解析

    2014.4 - 2016.3

    科学研究費補助金  挑戦的萌芽研究 ,課題番号26670121

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    Authorship:Principal investigator 

  6. ストレス応答性転写因子NPAS4欠損マウスにおけるGABA神経発達と表現型解析

    2013.4 - 2015.3

    科学研究費補助金  文部省科学研究費:新学術領域研究

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    Authorship:Principal investigator 

  7. アストログリア細胞のエンドサイトーシスの障害による神経発達障害

    2012.4 - 2014.3

    科学研究費補助金  文部省科学研究費:新学術領域研究

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    Authorship:Principal investigator 

  8. 広汎性発達障害と統合失調症のゲノム解析を起点として、発症因に基づく両疾患の診断体型再編と診断法開発を目指した研究多面発現的効果を有するゲノムコピー数変異(CNV)に着目して

    2011.4 - 2016.3

    科学研究費補助金  文部省科学研究費: 脳科学研究戦略推進プログラム

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    Authorship:Coinvestigator(s) 

  9. 化学物質による神経伝達物質受容体を介した精神毒性発現機序の解明および行動評価方法の開発に関する研究

    2008.4 - 2011.3

    科学研究費補助金  厚生労働科学研究費補助金:化学物質リスク研究事業

    鍋島俊隆

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    Authorship:Coinvestigator(s) 

  10. ドーパミン関連神経精神疾患モデルにおけるtPAの動態と機能解析

    2007.4 - 2011.3

    科学研究費補助金  基盤研究(B) 課題番号19390062

    山田清文

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    Authorship:Principal investigator 

  11. 精神刺激薬により誘発される神経精神毒性の分子機構の解明

    2007.4 - 2009.3

    科学研究費補助金  日本学術振興会二国間交流事業(韓国(KOSEF)との共同研究

    山田清文

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    Authorship:Principal investigator 

  12. 依存性および未規制薬物による神経毒性と精神病の発現機序に関する研究

    2004.4 - 2007.3

    科学研究費補助金  厚生労働省科研費:医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業

    鍋島俊隆

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    Authorship:Coinvestigator(s) 

  13. メタンフェタミンにより誘発される認知障害の機構の解明と治療法の確立

    2004.3 - 2007.3

    科学研究費補助金  厚生労働省科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究事

    鍋島俊隆

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    Authorship:Coinvestigator(s) 

    覚せい剤であるメタンフェタミンの乱用と依存に伴い誘発される認知障害に関する基礎研究

  14. 依存性薬物により誘発される精神障害の機構の解明の研究(分担課題:依存性薬物の報酬効果の神経機構に関する研究)

    2002.4 - 2005.3

    科学研究費補助金  科学技術振興調整費 目標達成型脳科学研究推進制度

    鍋島俊隆

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    Authorship:Coinvestigator(s) 

    モルヒネあるいはメタンフェタミンの摂取に伴い生じる快感や認知障害の神経回路とメカニズムに関する基礎研究

  15. 可塑的脳機能変化における組織プラスミノーゲン活性化因子の役割

    2002.4 - 2004.3

    科学研究費補助金  文部省科学研究費補助金:萌芽研究

    山田清文

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    Authorship:Principal investigator 

  16. 記憶形成における脳由来神経栄養因子(BDNF)の役割

    2000.4 - 2002.3

    科学研究費補助金  文部省科学研究費補助金:基盤研究(C)

    山田清文

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    Authorship:Principal investigator 

  17. ラット脳内における一酸化窒素の産生に対するストレスの影響

    1998.4 - 1999.3

    科学研究費補助金  文部省科学研究費補助金:奨励研究(B)

    山田清文

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    Authorship:Principal investigator 

  18. ラット脳内における一酸化窒素 (NO) の生成調節機構の解明

    1996.4 - 1997.3

    科学研究費補助金  文部省科学研究費補助金:奨励研究(B)

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Industrial property rights 2

  1. 異常行動を示す遺伝子改変非ヒト哺乳動物及びその作成方法

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    Application no:PCT/JP2008/063497  Date applied:2008.7

    Country of applicant:Domestic  

  2. Remedies for neurological disorders

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    Application no:PCT/JP99/00502  Date applied:1998.2

    Announcement no:WO99/39714 

    Country of applicant:Foreign country  

 

Teaching Experience (On-campus) 5

  1. Seminar on Neuropsychopharmacology and Hospital Pharmacy

    2020

  2. Experimental Research on Neuropsychopharmacology and Hospital Pharmacy

    2020

  3. 臨床薬理学

    2013

  4. 臨床薬理学

    2012

  5. 臨床薬理学

    2011

Teaching Experience (Off-campus) 23

  1. 神経科学入門

    2010.4 - 2011.3 東京大学大学院医学系研究科非常勤講師)

  2. 2008.4 - 2009.3 名古屋大学環境医学研究所特任講師)

  3. 機能形態学Ⅲ

    2008.4 - 2009.3 金沢大学薬学部客員教授)

  4. 医用工学特論Ⅱ

    2008.4 - 2009.3 名古屋工業大学大学院非常勤講師)

  5. 2008.4 - 2009.3 名城大学薬学部客員教授)

  6. 2007.4 - 2008.3 名城大学客員教授)

  7. 2007.4 - 2008.3 名城大学薬学部客員教授)

  8. 大学院特論

    2007.4 - 2008.3 京都大学大学院薬学研究科非常勤講師)

  9. 機能形態学Ⅲ

    2007.4 - 2008.3 金沢大学薬学部客員教授)

  10. 2005.4 - 2006.3 奈良先端科学技術大学院大学バイオサイエンス研究科非常勤講師)

  11. 2001.4 - 2002.3 名城大学薬学専攻科臨床指導講師)

  12. 2001.4 - 2002.3 新潟大学大学院医学研究科非常勤講師)

  13. 新薬論

    2001.4 - 2002.3 名城大学薬学部非常勤講師)

  14. 2000.4 - 2001.3 名城大学薬学専攻科臨床指導講師)

  15. 新薬論

    2000.4 - 2001.3 名城大学薬学部非常勤講師)

  16. 2000.4 - 2001.3 岐阜薬科大学(病院実習)非常勤講師)

  17. 1999.4 - 2000.3 名城大学薬学専攻科臨床指導講師)

  18. 1999.4 - 2000.3 岐阜薬科大学(病院実習)非常勤講師)

  19. 1998.4 - 1999.3 名城大学薬学専攻科臨床指導講師)

  20. 1998.4 - 1999.3 岐阜薬科大学(病院実習)非常勤講師)

  21. 1997.4 - 1998.3 名城大学薬学専攻科臨床指導講師)

  22. 1996.4 - 1997.3 名城大学薬学専攻科臨床指導講師)

  23. 1995.4 - 1996.3 名城大学薬学専攻科臨床指導講師)

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