Nagoya University

1998.10 - 2002.3

名古屋大学医学部附属病院　助教授・副薬剤部長

1998.6 - 2002.3

Nagoya University

1998.6 - 2002.3

名古屋大学医学部附属病院薬剤部　文部技官薬剤師

1993.4 - 2002.3

米国ジョンズホプキンス大学医学部　訪問研究員

1987.4 - 1989.5

大塚製薬株式会社徳島研究所　研究員

1983.4 - 1993.3

日本薬学会   医療薬科学部会世話人

2008.4

日本薬学会   東海支部幹事

2007.4 - 2011.1

日本神経化学会   評議員

1999.4

日本神経精神薬理学会   理事

2020.10

日本依存神経精神科学会   評議員

2014.9 - 2015.10

日本病院薬剤師会   理事

2014.7 - 2016.6

Asian College of Neuropsychopharmacology(AsCNP)   Council member

2011.4 - 2013.3

愛知県病院薬剤師会   副会長

2009.4 - 2015.5

Anthocyanin-rich blackcurrant extract improves long-term memory impairment and emotional abnormality in senescence-accelerated mice Reviewed

Shimada M, Maeda H, Nanashima N, Yamada K, Nakajima A

J Food Biochem   Vol. 46 ( 10 ) page： e14295   2022.10

A Survey on the Actual Use of and Reasons for Heated Tobacco Products in Patients with Rheumatoid Arthritis Reviewed

Isaji H, Yamada K

Int. J. Environ. Res. Public Health 2022   Vol. 19   page： 12465   2022.9

医療機関における薬剤師の卒後研修とキャリアパス

山田清文

  Vol. 142 ( 9 ) page： 965 - 969   2022.9

精神科外来患者における抗うつ薬および抗不安薬の多剤併用処方状況に関する調査 Reviewed

肥田裕丈、磯貝里奈、野口健、堀田彰悟、吉見陽、尾崎紀夫、山田清文、野田幸裕

医療薬学   Vol. 48 ( 9 ) page： 359 - 367   2022.9

Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia Reviewed

Takase S, Liao J, Liu Y, Tanaka R, Miyagawa Y, Sawahata M, Sobue A, Mizoguchi H, Nagai T, Kaibuchi K, Ozaki N, Yamada K

European Journal of Pharmacology   Vol. 931   2022.9

シリーズ 薬剤師レジデント制度 名古屋大学医学部附属病院における取り組み

千崎康司、山田清文

日本病院薬剤師会雑誌   Vol. 58 ( 9 ) page： 1013 - 1016   2022.9

Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning Reviewed

Yamahashi Y, Lin YH, Mouri A, Iwanaga S, Kawashima K, Tokumoto Y, Watanabe Y, Faruk MO, Zhang X, Tsuboi D, Nakano T, Nagai T, Yamada K, Kaibuchi K

Mol Psychiatry   Vol. 27 ( 8 ) page： 3479 - 3492   2022.8

フェンタニル舌下錠の突出痛コントロール不良に至るリスク因子の探索 Reviewed

加藤 博史、成瀬 亮、長谷川 真由、宮崎 雅之、千﨑 康司、野田 幸裕、山田 清文

日本緩和医療薬学雑誌   Vol. 15 ( 2 ) page： 47 - 51   2022.6

精巣胚細胞腫瘍に対する低用量シスプラチン分割投与におけるアプレピタントの制吐効果 Reviewed

中村 真理子、蛯江 裕美、吉見 陽、肥田 裕丈、田中 理子、宮崎 雅之、山田 清文、野田 幸裕

日本緩和医療薬学雑誌   Vol. 15 ( 2 ) page： 33 - 40   2022.6

免疫チェックポイント阻害薬の有効性及び安全性に対する抗菌薬使用の影響 Reviewed

  Vol. 48 ( 5 ) page： 173 - 193   2022.5

Rho–Rho‑kinase regulates Ras‑ERK signaling through SynGAP1 for dendritic spine morphology Reviewed

Wu M, Funahashi Y, Takano T, Hossen E, Ahammad RU, Tsuboi D, Amano M, Yamada K, Kaibuchi K

Neurochem. Res     2022.5

A machine learning model that emulates experts’ decision making in vancomycin initial dose planning Reviewed

Matsuzaki T,Kato Y,Mizoguchi H,Yamada k

Journal of Pharmacological Sciences. 2022 Volume 148   Vol. 148 ( 4 ) page： 358 - 363   2022.4

周術期抗菌薬の適正使用に向けた取り組みとアウトカム評価 Reviewed

渡部 亨平, 稲垣 孝行, 今 俊介, 高野 雅己, 松原 匡希, 森岡 悠, 八木 哲也, 山田 清文

日本化学療法学会雑誌   Vol. 71 ( 2 ) page： 123 - 132   2022.3

Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning Reviewed

Faruk,Mo,Tsuboi D,Yamahashi Y,Funahashi Y,Lin YH,TzingounisAV,Yamada K,NagaiT,kaibuchi K

Journal Of Neurochemistry     2022.2

New strategies for the treatment of neuropsychiatric disorders based on Reelin dysfunction

Tsuneura Y, Nakai T, Mizoguchi H, Yamada K

Int. J. Mol. Sci.   Vol. 23 ( 3 ) page： 1829   2022.2

Muscarinic signaling regulates voltage‐gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning Reviewed

Faruk MO, Tsuboi D, Yamahashi Y, Funahashi Y, Lin YS, Ahammad RU, Hossen E, Amano N, Nishioka T, Tzingounis AV, Yamada K, Nagai T, Kaibuchi K

  Vol. 160 ( 3 ) page： 325 - 341   2022.2

Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks. Reviewed

Liao,JZ,Dong,GY，Wulaer B,Sawahata M,Mizoguchi H,Mori D,Ozaki N,Nabeshima T,Nagai T,Yamada K.

BEHAVIOURAL BRAIN RESEARCH.   Vol. 416 ( 7 )   2022.1

KANPHOS: A Database of Kinase-Associated Neural Protein hosphorylation in the Brain Reviewed

Ahammad RU,Nishioka T,Yoshimoto J,Kannon T,Amano M,Funahashi Y,Tsuboi D,Faruk Mo,Yamahashi Y,Yamada K,Nagai T, Kaibuchi K

Cells   Vol. 11 ( 1 )   2022.1

Clinical impact of standardized creatinine on dose adjustment of capecitabine Reviewed

Ito A, Ichikawa K, Miyazaki M, Sagara A, Motegi T, Ando Y, Senzaki K, Nagai T, Yamada K.

  ( 84 ) page： 547 - 553   2022

Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice Reviewed

Uchida M,Noda Y,Hasegawa S,Hida H,Taniguchi M,Mouri A,Yoshimi A,Nabeshima T,Yamada K,Aida T,Tanaka K,Ozaki N

Neurochemistry international     2021.11

Survey of chemotherapy-induced nausea and vomiting in patients with urothelial carcinoma.

Yoshimi A, Shiroma Y, Iwata M, Nakamura M, Torii-Goto A, Hida H, Tanaka N, Miyazaki M, Yamada K, Noda Y

Molecular and clinical oncology   Vol. 15 ( 4 ) page： 219   2021.10

Survey of chemotherapy-induced nausea and vomiting in patients eith urothelial carcinoma Reviewed

Yoshimi A,Shiroma Y,Iwata M,Nakamura M,Torii-Goto A,Hida H,Tanaka N,Miyazaki M,Yamada K,Noda Y

Molecular and Clinical Oncology   Vol. 15 ( 4 )   2021.8

Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice Reviewed

Sawahata M,AsanoH,Nagai T,Ito N,Kohno T,Nabeshima T,Hattori M,Yamada K

Pharmacological Research   Vol. 173 ( 105832 )   2021.8

Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice Reviewed

Mizoguchi A,Banno R,Sun R,Yaginuma H,Taki K,Kobayashi T,Sugiyama M,Tsunekawa T,Onoue T,Takagi H,Hagiwara D,Ito Y,Iwama S,Suga H,Nagai T,Yamada K,Arima H.

Scientific Report   Vol. 11 ( 1 )   2021.6

精神疾患の適切な診断と評価に基づく向精神薬の適正使用 Reviewed

尾崎紀夫、山田清文、鳥本真由美、森川真子

臨床精神薬理   Vol. 24 ( 5 )   2021.5

Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus Reviewed

Wulaer B, Kunisawa K, Hada K, Jaya Suento W, Kubota H, Iida T, Kosuge A, Nagai T, Yamada K, Nitta A, Yamamoto Y, Saito K, Mouri A, Nabeshima T

J. Neurochem   Vol. 157   page： 642 - 655   2021.5

Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia. Reviewed

Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K

Neurochemistry international   Vol. 144   page： 104954   2021.3

ベンゾジアゼピン系薬の長期使用患者におけるスボレキサントの導入に関する後方視的調査 Reviewed

堀田彰悟、肥田裕丈、松原匡希、宮崎雅之、野田幸裕、山田清文

医療薬学   Vol. 47 ( 3 ) page： 123 - 131   2021.3

Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway Reviewed

Lin You-Hsin, Yamahashi Yukie, Kuroda Keisuke, Faruk Omar, Zhang Xinjian, Yamada Kiyofumi, Yamanaka Akihiro, Nagai Taku, Kaibuchi Kozo

NEUROCHEMISTRY INTERNATIONAL   Vol. 143   page： 104935   2021.2

Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons Reviewed

Hada Kazuhiro, Wulaer Bolati, Nagai Taku, Itoh Norimichi, Sawahata Masahito, Sobue Akira, Mizoguchi Hiroyuki, Mori Daisuke, Kushima Itaru, Nabeshima Toshitaka, Ozaki Norio, Yamada Kiyofumi

MOLECULAR BRAIN   Vol. 14 ( 1 ) page： 21   2021.1

新型コロナウイルス感染症流行下における情報通信技術を用いた薬学病院実習の取り組みと学生からの評価 Reviewed

羽田和弘、千﨑康司、等浩太郎、白松貴子、吉見陽、野田幸裕、山田清文

医療薬学   Vol. 48 ( 1 ) page： 20 - 34   2021.1

Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice Reviewed

Wulaer Bolati, Hada Kazuhiro, Sobue Akira, Itoh Norimichi, Nabeshima Toshitaka, Nagai Taku, Yamada Kiyofumi

MOLECULAR BRAIN   Vol. 13 ( 1 ) page： 170   2020.12

Short hydration with 20 mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy: a prospective study Reviewed

Hase Tetsunari, Miyazaki Masayuki, Ichikawa Kazuya, Yogo Naoyuki, Ozawa Naoya, Hatta Takahiro, Ando Masahiko, Sato Mitsuo, Kondo Masashi, Yamada Kiyofumi, Hasegawa Yoshinori

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 11 ) page： 1928 - 1935   2020.11

Reelin Supplementation Into the Hippocampus Rescues Abnormal Behavior in a Mouse Model of Neurodevelopmental Disorders Reviewed

Ibi Daisuke, Nakasai Genki, Koide Nayu, Sawahata Masahito, Kohno Takao, Takaba Rika, Nagai Taku, Hattori Mitsuharu, Nabeshima Toshitaka, Yamada Kiyofumi, Hiramatsu Masayuki

FRONTIERS IN CELLULAR NEUROSCIENCE   Vol. 14   page： 285   2020.9

Comparing incidences of infusion site reactions between brand-name and generic vinorelbine in patients with non-small cell lung cancer Reviewed

Ozawa Naoya, Hase Tetsunari, Hatta Takahiro, Sagara Atsunobu, Ichikawa Kazuya, Miyazaki Masayuki, Yogo Naoyuki, Ando Masahiko, Hashimoto Naozumi, Yamada Kiyofumi, Hasegawa Yoshinori

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY   Vol. 87 ( 3 ) page： 1318 - 1326   2020.8

Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days Reviewed

Sato Yoshitaka, Iguchi Mitsutaka, Kato Yoshiaki, Morioka Hiroshi, Hirabayashi Aki, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yamada Kiyofumi, Kimura Hiroshi, Yagi Tetsuya

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page： 407 - 414   2020.8

ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk Reviewed

Sekiguchi Mariko, Sobue Akira, Kushima Itaru, Wang Chenyao, Arioka Yuko, Kato Hidekazu, Kodama Akiko, Kubo Hisako, Ito Norimichi, Sawahata Masahito, Hada Kazuhiro, Ikeda Ryosuke, Shinno Mio, Mizukoshi Chikara, Tsujimura Keita, Yoshimi Akira, Ishizuka Kanako, Takasaki Yuto, Kimura Hiroki, Xing Jingrui, Yu Yanjie, Yamamoto Maeri, Okada Takashi, Shishido Emiko, Inada Toshiya, Nakatochi Masahiro, Takano Tetsuya, Kuroda Keisuke, Amano Mutsuki, Aleksic Branko, Yamomoto Takashi, Sakuma Tetsushi, Aida Tomomi, Tanaka Kohichi, Hashimoto Ryota, Arai Makoto, Ikeda Masashi, Iwata Nakao, Shimamura Teppei, Nagai Taku, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi, Mori Daisuke, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   Vol. 10 ( 1 ) page： 247   2020.7

AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication Reviewed

Hori Kei, Yamashiro Kunihiko, Nagai Taku, Shan Wei, Egusa Saki F., Shimaoka Kazumi, Kuniishi Hiroshi, Sekiguchi Masayuki, Go Yasuhiro, Tatsumoto Shoji, Yamada Mitsuyo, Shiraishi Reika, Kanno Kouta, Miyashita Satoshi, Sakamoto Asami, Abe Manabu, Sakimura Kenji, Sone Masaki, Sohya Kazuhiro, Kunugi Hiroshi, Wada Keiji, Yamada Mitsuhiko, Yamada Kiyofumi, Hoshino Mikio

ISCIENCE   Vol. 23 ( 6 ) page： 101183   2020.6

Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus Reviewed

Wulaer Bolati, Kunisawa Kazuo, Hada Kazuhiro, Suento Willy Jaya, Kubota Hisayoshi, Iida Tsubasa, Kosuge Aika, Nagai Taku, Yamada Kiyofumi, Nitta Atsumi, Yamamoto Yasuko, Saito Kuniaki, Mouri Akihiro, Nabeshima Toshitaka

JOURNAL OF NEUROCHEMISTRY     2020.5

Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia Reviewed

Sawahata Masahito, Mori Daisuke, Arioka Yuko, Kubo Hisako, Kushima Itaru, Kitagawa Kanako, Sobue Akira, Shishido Emiko, Sekiguchi Mariko, Kodama Akiko, Ikeda Ryosuke, Aleksic Branko, Kimura Hiroki, Ishizuka Kanako, Nagai Taku, Kaibuchi Kozo, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 74 ( 5 ) page： 318 - 327   2020.5

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus Reviewed

Saito Ryo, Koebis Michinori, Nagai Taku, Shimizu Kimiko, Liao Jingzhu, Wulaer Bolati, Sugaya Yuki, Nagahama Kenichiro, Uesaka Naofumi, Kushima Itaru, Mori Daisuke, Maruyama Kazuaki, Nakao Kazuki, Kurihara Hiroki, Yamada Kiyofumi, Kano Masanobu, Fukada Yoshitaka, Ozaki Norio, Aiba Atsu

TRANSLATIONAL PSYCHIATRY   Vol. 10 ( 1 ) page： 35   2020.2

Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors

Funahashi Yasuhiro, Ariza Anthony, Emi Ryosuke, Xu Yifan, Shan Wei, Suzuki Ko, Kozawa Sachi, Ahammad Rijwan Uddin, Wu Mengya, Takano Tetsuya, Yura Yoshimitsu, Kuroda Keisuke, Nagai Taku, Amano Mutsuki, Yamada Kiyofumi, Kaibuchi Kozo

CELL REPORTS   Vol. 29 ( 10 ) page： 3235 - +   2019.12

Effects of Renal Function Evaluation with or without Serum Creatinine Adjustment on Cisplatin/Fluorouracil Therapy for Cervical Cancer

Takagi Mai, Sagara Atsunobu, Ishizawa Ayumi, Ito Ayaka, Miyazaki Masayuki, Senzaki Kouji, Nagai Taku, Yamada Kiyofumi

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   Vol. 139 ( 10 ) page： 1327 - 1332   2019.10

Pharmacological and proteomic analyses of neonatal polyI:C-treated adult mice

Kitagawa Kanako, Nagai Taku, Yamada Kiyofumi

NEUROSCIENCE RESEARCH   Vol. 147   page： 39 - 47   2019.10

Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration

Uchida Mizuki, Hida Hirotake, Mori Kentaro, Yoshimi Akira, Kitagaki Shinji, Yamada Kiyofumi, Hiraoka Yuichi, Aida Tomomi, Tanaka Kohichi, Ozaki Norio, Noda Yukihiro

EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 29 ( 8 ) page： 914 - 924   2019.8

Methylation analysis for postpartum depression: a case control study

Nakamura Yukako, Nakatochi Masahiro, Kunimoto Shohko, Okada Takashi, Aleksic Branko, Toyama Miho, Shiino Tomoko, Morikawa Mako, Yamauchi Aya, Yoshimi Akira, Furukawa-Hibi Yoko, Nagai Taku, Ohara Masako, Kubota Chika, Yamada Kiyofumi, Ando Masahiko, Ozaki Norio

BMC PSYCHIATRY   Vol. 19 ( 1 ) page： 190   2019.6

Exploring Molecular Targets for Epilepsy Treatment from the Perspective of Neuronal Homeostasis

Nagai Taku, Shan Wei, Yamada Kiyofumi

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   Vol. 139 ( 6 ) page： 923 - 929   2019.6

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

Yoshimi Akira, Yamada Shinnosuke, Kunimoto Shohko, Aleksic Branko, Hirakawa Akihiro, Ohashi Mitsuki, Matsumoto Yurie, Hada Kazuhiro, Itoh Norimichi, Arioka Yuko, Kimura Hiroki, Kushima Itaru, Nakamura Yukako, Shiino Tomoko, Mori Daisuke, Tanaka Satoshi, Hamada Shuko, Noda Yukihiro, Nagai Taku, Yamada Kiyofumi, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   Vol. 9 ( 1 ) page： 126   2019.4

Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

Hasegawa Sho, Yoshimi Akira, Mouri Akihiro, Uchida Yoji, Hida Hirotake, Mishina Masayoshi, Yamada Kiyofumi, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

NEUROPHARMACOLOGY   Vol. 148   page： 107 - 116   2019.4

Methamphetamine use causes cognitive impairment and altered decision-making

Mizoguchi Hiroyuki, Yamada Kiyofumi

NEUROCHEMISTRY INTERNATIONAL   Vol. 124   page： 106 - 113   2019.3

Nicotine and varenicline ameliorate changes in reward-based choice strategy and altered decision-making in methamphetamine-treated rats

Mizoguchi Hiroyuki, Wang Tian, Kusaba Mizuki, Fukumoto Kazuya, Yamada Kiyofumi

BEHAVIOURAL BRAIN RESEARCH   Vol. 359   page： 935 - 941   2019.2

Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons

Zhang Xinjian, Nagai Taku, Ahammad Rijwan Uddin, Kuroda Keisuke, Nakamuta Shinichi, Nakano Takashi, Yukinawa Naoto, Funahashi Yasuhiro, Yamahashi Yukie, Amano Mutsuki, Yoshimoto Junichiro, Yamada Kiyofumi, Kaibuchi Kozo

NEUROCHEMISTRY INTERNATIONAL   Vol. 122   page： 8 - 18   2019.1

Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1(Delta 2-3/Delta 2-3) mice

Wulaer B., Nagai T., Sobue A., Itoh N., Kuroda K., Kaibuchi K., Nabeshima T., Yamada K.

GENES BRAIN AND BEHAVIOR   Vol. 17 ( 8 )   2018.11

Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3. Reviewed

Yamada S, Itoh N, Nagai N, Nakai T, Ibi D, Nakajima A, Nabeshima T, Yamada K.

J Neuroimmunol.   Vol. 15 ( 1 ) page： 295   2018.10

Short Hydration Regimen with a Modified Dose of Magnesium Supplementation for Lung Cancer Patients Receiving Cisplatin-Based Chemotherapy

Hase T., Miyazaki M., Ichikawa K., Yogo N., Ozawa N., Ando M., Morise M., Sato M., Kondo M., Yamada K., Hasegawa Y.

JOURNAL OF THORACIC ONCOLOGY   Vol. 13 ( 10 ) page： S880 - S880   2018.10

Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice

Bin Saifullah Md. Ali, Nagai Taku, Kuroda Keisuke, Wulaer Bolati, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi

SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page： 14413   2018.9

Dysfunction of serotoninergic and dopaminergic neuronal systems in the antidepressant-resistant impairment of social behaviors induced by social defeat stress exposure as juveniles. Reviewed

Hasegawa S, Miyake Y, Yoshimi A, Mouri A, Hida H, Yamada K, Ozaki N, Nabeshima T, Noda Y

The international journal of neuropsychopharmacology   Vol. 21 ( 9 ) page： 837 - 846   2018.9

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia. Reviewed

Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N

Scientific reports   Vol. 8 ( 1 ) page： 13046   2018.8

Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis Reviewed

Mouri Akihiro, Ukai Mayu, Uchida Mizuki, Hasegawa Sho, Taniguchi Masayuki, Ito Takahiro, Hida Hirotake, Yoshimi Akira, Yamada Kiyofumi, Kunimoto Shohko, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

NEUROPHARMACOLOGY   Vol. 133   page： 23-37   2018.5

Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes Reviewed

Sobue Akira, Ito Norimichi, Nagai Taku, Shan Wei, Hada Kazuhiro, Nakajima Akira, Murakami Yuki, Mouri Akihiro, Yamamoto Yasuko, Nabeshima Toshitaka, Saito Kuniaki, Yamada Kiyofumi

GLIA   Vol. 66 ( 5 ) page： 1034 - 1052   2018.5

Protein Kinase C delta Gene Depletion Protects Against Methamphetamine-Induced Impairments in Recognition Memory and ERK1/2 Signaling via Upregulation of Glutathione Peroxidase-1 Gene Reviewed

The-Vinh Tran, Shin Eun-Joo, Lan Thuy Ty Nguyen, Lee Youngho, Kim Dae-Joong, Jeong Ji Hoon, Jang Choon-Gon, Nah Seung-Yeol, Toriumi Kazuya, Nabeshima Toshitaka, Yamada Kiyofumi, Kim Hyoung-Chun

MOLECULAR NEUROBIOLOGY   Vol. 55 ( 5 ) page： 4136-4159   2018.5

Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy.

Tajima H, Izumi T, Miyachi S, Matsubara N, Ito M, Imai T, Nishihori M, Shintai K, Okamoto S, Araki Y, Kumakura Y, Furukawa-Hibi Y, Yamada K, Wakabayashi T

Nagoya journal of medical science   Vol. 80 ( 2 ) page： 207 - 215   2018.5

Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a Reviewed

Shan Wei, Nagai Taku, Tanaka Motoki, Itoh Norimichi, Furukawa-Hibi Yoko, Nabeshima Toshitaka, Sokabe Masahiro, Yamada Kiyofumi

JOURNAL OF NEUROCHEMISTRY   Vol. 145 ( 1 ) page： 19 - 33   2018.4

Efficacy of Prophylactic Treatment for Oxycodone-Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo-Controlled, Double-Blind Trial Reviewed

Tsukuura Hiroaki, Miyazaki Masayuki, Morita Tatsuya, Sugishita Mihoko, Kato Hiroshi, Murasaki Yuka, Gyawali Bishal, Kubo Yoko, Ando Masahiko, Kondo Masashi, Yamada Kiyofumi, Hasegawa Yoshinori, Ando Yuichi

ONCOLOGIST   Vol. 23 ( 3 ) page： 367 - 374   2018.3

Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice Reviewed

Phuong-Tram Nguyen, Shin Eun-Joo, Dang Duy-Khanh, Tran Hai-Quyen, Jang Choon-Gon, Jeong Ji Hoon, Lee Yu Jeung, Lee Hyo Jong, Lee Yong Sup, Yamada Kiyofumi, Nabeshima Toshitaka, Kim Hyoung-Chun

NEUROCHEMISTRY INTERNATIONAL   Vol. 113   page： 69-84   2018.2

Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein Reviewed

Itoh Norimichi, Nagai Taku, Watanabe Takashi, Taki Kentaro, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 493 ( 4 ) page： 1384 - 1389   2017.12

MK-801, but not naloxone, attenuates high-dose dextromethorphan-induced convulsive behavior: Possible involvement of the GluN2B receptor

Hai-Quyen Tran, Chung Yoon Hee, Shin Eun-Joo, The-Vinh Tran, Jeong Ji Hoon, Jang Choon-Gon, Nah Seung-Yeol, Yamada Kiyofumi, Nabeshima Toshitaka, Kim Hyoung-Chun

TOXICOLOGY AND APPLIED PHARMACOLOGY   Vol. 334   page： 158 - 166   2017.11

Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice Reviewed

The-Vinh Tran, Shin Eun-Joo, Jeong Ji Hoon, Lee Ji Won, Lee Youngho, Jang Choon-Gon, Nah Seung-Yeol, Lei Xin Gen, Toriumi Kazuya, Yamada Kiyofumi, Nabeshima Toshitaka, Kim Hyoung-Chun

MOLECULAR NEUROBIOLOGY   Vol. 54 ( 9 ) page： 7042-7062   2017.11

A new nomenclature for classifying psychotropic drugs Reviewed

Caraci Filippo, Enna Sam J., Zohar Joseph, Racagni Giorgio, Zalsman Gil, van den Brink Wim, Kasper Siegfried, Koob George F., Pariante Carmine M., Piazza Pier Vincenzo, Yamada Kiyofumi, Spedding Michael, Drago Filippo

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY   Vol. 83 ( 8 ) page： 1614-1616   2017.8

The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization. Reviewed

Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T

Behavioural Brain Research     page： 157-165   2017.6

Incidence of and risk factors associated with nedaplatin-related hypersensitivity reactions

Kawarada Yuki, Miyazaki Masayuki, Itoh Ayaka, Araki Risa, Iwamizu Hidetaka, Kataoka Tomomi, Kumakura Yasuo, Ota Akiko, Nagai Taku, Yamada Kiyofumi

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 22 ( 3 ) page： 593 - 599   2017.6

Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice. Reviewed

Konishi H, Ohgami N, Matsushita A, Kondo Y, Aoyama Y, Kobayashi M, Nagai T, Ugawa S, Yamada K, Kato M, Kiyama H

Neuroscience   Vol. 351   page： 15-23   2017.5

Association of impaired neuronal migration with cognitive deficits in extremely preterm infants Reviewed

Kubo Ken-Ichiro, Deguchi Kimiko, Nagai Taku, Ito Yukiko, Yoshida Keitaro, Endo Toshihiro, Benner Seico, Shan Wei, Kitazawa Ayako, Aramaki Michihiko, Ishii Kazuhiro, Shin Minkyung, Matsunaga Yuki, Hayashi Kanehiro, Kakeyama Masaki, Tohyama Chiharu, Tanaka Kenji F., Tanaka Kohichi, Takashima Sachio, Nakayama Masahiro, Itoh Masayuki, Hirata Yukio, Antalffy Barbara, Armstrong Dawna D., Yamada Kiyofumi, Inoue Ken, Nakajima Kazunori

JCI INSIGHT   Vol. 2 ( 10 )   2017.5

Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors Reviewed

Shin Eun-Joo, Duy-Khanh Dang, The-Vinh Tran, Hai-Quyen Tran, Jeong Ji Hoon, Nah Seung-Yeol, Jang Choon-Gon, Yamada Kiyofumi, Nabeshima Toshitaka, Kim Hyoung-Chun

ARCHIVES OF PHARMACAL RESEARCH   Vol. 40 ( 4 ) page： 403-428   2017.4

[Analysis of Nedaplatin Dose in Patients with Impaired Renal Function]. Reviewed

Araki R, Iwamizu H, Kataoka T, Kumakura Y, Miyazaki M, Nagai T, Ando Y, Yamada K

Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 44 ( 2 ) page： 143-147   2017.2

Risk factors for postoperative delirium in abdominal surgery: a proposal of a postoperative delirium risk score in abdominal surgery. Reviewed

Miyagawa Y, Yokoyama Y, Fukuzawa S, Fukata S, Ando M, Kawamura T, Yamada K, Nagino M.

Digestive Surgery     page： 95-102   2017

Phospho-proteomics of the dopamine pathway enables discovery of Rap1 activation as a reward signal in vivo. Reviewed

Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K.

Neuron   Vol. 89   page： 550-565   2016

Molecular mechanism linking BDNF/TrkB signaling with the NMDA receptor in memory: The role of Girdin in the CNS. Reviewed

Itoh N, Enomoto A, Nagai T, Takahashi M, Yamada K

Rev Neurosci.   Vol. 27   page： 481-90   2016

Association of axitinib plasma exposure and genetic polymorphisms of ABC transporters with axitinib-induced toxicities in patients with renal cell carcinoma. Reviewed

Kato H, Sassa N, Miyazaki M, Takeuchi M, Asai M, Iwai A, Noda Y, Gotoh M, Yamada K.

Cancer Chemother. Pharmacol.   Vol. 78   page： 855-862   2016

Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease. Reviewed

Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, ueda M, Yamamoto A

Behav Brain Res   Vol. 293   page： 189-197   2015.10

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease(3XTg-AD). Reviewed

Nakajima A, Aoyama Y, Shin EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi T, Ohizumi Y, Yamada K

  Vol. 289   page： 69-77   2015.8

Insular neural system controls decision-making in healthy and methamphetamine-treated rats. Reviewed

Hiroyuki Mizoguchi, Kentaro Katahira, Ayumu Inutsuka, Kazuya Fukumoto, Akihiro Nakamura, Tian Wang, Taku Nagai, Jun Sato, Makoto Sawade, Hideki Ohira, Akihiro Yamanaka, Kiyofumi Yamada

Proc. Natl. Acad. Sci. USA.     page： 3930-3939   2015.7

Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene. Reviewed

Yoko Furukawa-Hibi, Taku Nagai, Jaesuk Yun, Kiyofumi Yamada

Neuroreport.     2015.7

A retrospective study to identify risk factors for somenolence and dizziness in patients treated with pregabalin. Reviewed

Hiroshi Kato, Masayuki Miyazaki, Mio Takeuchi, Hiroaki Tsukuura, Mihoko Sugishita, Yukihiro Noda, Kiyofumi Yamada.

J.Pharm.Health Care Sci.     2015.7

Prenatal nicotine exposure impairs the proliferation of neuronal progenitors, leading to fewer glutamatergic neurons in the medial prefrontal cortex. Reviewed

Yuki Aoyama, Kazuya Toriumi, Akihiro Mouri, Tomoya Hattori, Eriko Ueda, Akane Shimato, Nami Sakakibara, Yuka Soh, Takayoshi Mamiya, Taku Nagai, Hyoung-Chun Kim, Masayuki Hiramatsu, Toshitaka Nabeshima, Kiyofumi Yamada

Neuropsychopharmacology     page： 1-12   2015.6

FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization. Reviewed

Tsuyoshi Udagawa, Yusuke Fujioka, Motoki Tanaka, Daiyu Honda, Satoshi Yokoi, Yuichi Riku, Daisuke Ibi, Taku Nagai, Kiyofumi Yamada, Hirohisa Watanabe, Masahisa Katsuno, Toshifumi Inada, Kinji Ohno, Masahiro Sokabe, Haruo Okado, Shinsuke Ishigaki, Gen Sobue

Nature Communications     2015.5

A successful case of a patient undergoing warfarin and S-1 therapy using Internet-based control of home-measured PT-INR. Reviewed

Keiko Yamamura, Koji Yano, Yoshiki Hirooka, Akihiro Hirashiki, Toyoaki Murohara, Kiyofumi Yamada

YAKUGAKU ZASSHI.   Vol. 135 ( 7 ) page： 925-927   2015.4

Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: The Complex Mechanism of Blonanserin Action Involving D3-5-HT2A and D1-NMDA Receptors in the mPFC. Reviewed

Hirotake Hida, Akihiro Mouri, Kentaro Mori, Yurie Matsumoto, Takeshi Seki, Masayuki Taniguchi, Kiyofumi Yamada, Kunihiro Iwamoto, Norio Ozaki, Toshitaka Nabeshima, Yukihiro Noda

Neuropsychopharmacology   Vol. 40 ( 3 ) page： 601-613   2015.2

Pharmacist-managed clinics for patient education and counseling in Japan: current status and future perspectives. Reviewed

Kiyofumi Yamada, Toshitaka Nabeshima

J.Pharm.Health Care Sci.     2015.1

Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits. Reviewed

Kazuhiro Ishii, Taku Nagai, Yuki Hirota, Mariko Noda, Toshitaka Nabeshima, Kiyofumi Yamada, Ken-ichiro Kubo, Kazunori Nakajima

Neurosci. Res.   Vol. 96 ( 2015 ) page： 30-36   2015.1

Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes. Reviewed

Akira Nakajima, Daisuke Ibi, Taku Nagai, Shinnosuke Yamada, Toshitaka Nabeshima, Kiyofumi Yamada

European Journal of Pharmacology   Vol. 745   page： 166-175   2014.12

Cytoskeletal Regulation by AUTS2 in Neuronal Migration and Neuritogenesis. Reviewed

Kei Hori , Taku Nagai , Wei Shan , Asami Sakamoto , Shinichiro Taya , Ryoya Hashimoto , Takashi Hayashi , Manabu Abe , Maya Yamazaki , Keiko Nakao , Tomoki Nishioka , Kenji Sakimura , Kiyofumi Yamada , Kozo Kaibuchi , Mikio Hoshino

Cell Reports   Vol. 9   page： 2166-2179   2014.12

Girdin Phosphorylation Is Crucial for Synaptic Plasticity and Memory: A Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor. Reviewed

Tsuyoshi Nakai, Taku Nagai, Motoki Tanaka, Norimichi Itoh, Naoya Asai, Atsushi Enomoto, Masato Asai, Shinnosuke Yamada, Ali Bin Saifullah, Masahiro Sokabe, Masahide Takahashi, Kiyofumi Yamada

The Journal of Neuroscience   Vol. 34 ( 45 ) page： 14995-15008   2014.11

Clinical relevance of post-transplant pharmacodynamics analysis of cyclosporine in transplantation. Reviewed

Kurata Y, Kuzuya T, Miwa Y, Iwasaki K, Haneda M, Amioka K, Yamada K, Watari Y, Katayama A, Uchida K, Kobayashi T

Int. Immunophamacol   Vol. 22 ( 2 ) page： 384-391   2014.10

Npas4 Regulates Mdm2 and thus Dcx in Experience-Dependent Dendritic Spine Development of Newborn Olfactory Bulb Interneurons. Reviewed

Sei-ichi Yoshihara, Hiroo Takahashi, Nobushiro Nishimura, Masahito Kinoshita, Ryo Asahina, Michiko Kitsuki, Kana Tatsumi, Yoko Furukawa-Hibi, Hirokazu Hirai, Taku Nagai, Kiyofumi Yamada, Akio Tsuboi

Cell Reports   Vol. 8   page： 1-15   2014.8

Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies. Reviewed

Akira Nakajima, Yasushi Ohizumi, Kiyofumi Yamada

Clinical Psychopharmacology and Neuroscience   Vol. 12 ( 2 ) page： 75-82   2014.8

Alterations of GABAergic and domainergic system in mutant mice with disruption of exons 2 and 3 of the Disc1 gene. Reviewed

Nakai T, Nagai T, Wang R, Yamada S, Kuroda K, Kaibuchi K, Yamada K

Neurochem. Int.   Vol. 74   page： 74-83   2014.7

Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor. Reviewed

Yuki Aoyama, Akihiro Mouri, Kazuya Toriumi, Takenao Koseki, Shiho Narusawa, Natsumi Ikawa, Takayoshi Mamiya, Taku Nagai, Kiyofumi Yamada, Toshitaka Nabeshima

International Journal of Neuropsychopharmacology   Vol. 17 ( 5 ) page： 723-737   2014.5

Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes. Reviewed

Shinnnosuke Yamada, Taku Nagai, Tsuyoshi Nakai, Daisuke Ibi, Akira Nakajima, Kiyofumi Yamada

Brain,Behavior, and Immunity   Vol. 38   page： 272-282   2014.5

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Reviewed

Yukio Mano, Tomomi Kotani, Mikako Ito, Taku Nagai, Yuko Ichinohashi, Kiyofumi Yamada, Kinji Ohno, Fumitaka Kikkawa, Shinya Toyokuni.

Free Radical Biology and Medicine   Vol. 69   page： 324-330   2014.4

Alteration of gene expression and DNA methylation in drug-resistant gastric cancer. Reviewed

Maeda O, Ando T, Ohmiya N, Isiguro K, Watanabe O, Miyahara R, Hibi Y, Nagai T, Yamada K

Oncol Rep   Vol. 31   page： 1883-1890   2014.4

Deletion of SHATI/NAT8L increases dopamineD1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Reviewed

Kazuya Toriumi, Mizuki Kondo, Taku Nagai, Ryota Hashimoto, Kazutaka Ohi, Ziyu Song,Junko Tanaka, Akihiro Mouri, Takenao Koseki, Hidenaga Yamamori, Yoko Furukawa-Hibi, Takayoshi Mamiya, Takeshi Fukushima, Masatoshi Takeda, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima.

International Journal of Neuropsychopharmacology   Vol. 17 ( 3 ) page： 443-53   2014.3

Combination of neonatal Polyl:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Reviewed

Hirotake Hida,Akihiro Mouri,Yu Ando,Kentaro Mori,Takayoshi Mamiya,Kunihiro Iwamoto,Norio Ozaki,Kiyofumi Yamada,Toshitaka Nabeshima,Yukihiro Noda.

Behavioural Brain Research.   Vol. 258   page： 34-42   2014.1

Evalution of cognitive behaviors in young offspring of C57BL/6J mice after gestational nicotine exposure during different time-windows

Tursun Alkam, Hyoung-Chun Kim, Takayoshi Mamiya, Kiyofumi Yamada, Masayuki Hiramatsu, Toshitaka Nabeshima

Psychopharmacology   Vol. 230 ( 3 ) page： 451-463   2013.12

Role of Matrix Metalloproteinases and Their in Epileptogenesis and Seizures.

Hiroyuki Mizoguchi,Kiyofumi Yamada.

Clinical Psychopharmacology and Neuroscience.   Vol. 11 ( 2 ) page： 45-52   2013.8

Role of convergent activation of glutamatergic and dopaminergic systems in the nucleus accumbens in the development of methamphetamine psychosis and dependence.

Masayuki Miyazaki,Yukihiro Noda,Akihiro Mouri,Kazuto Kobayashi,Masayoshi Mishima,Toshitaka Nabeshima,Kiyofumi Yamada.

Int J Neuropsychopharmacol.   Vol. 16 ( 6 ) page： 1341-1350   2013.7

Correlation of CYP2C19 Phenotype With Voriconazole Plasma Concentration in Children

Atsushi Narita, Hideki Muramatsu, Hirotoshi Sakaguchi, Sayoko Doisaki, Makito Tanaka, Asahito Hama, Akira Shimada, Yoshiyuki Takahashi, NaoYoshida, Kimikazu Matsumoto, Koji Kato, Kazuko Kudo, Yoko Furukawa-Hibi, Kiyofumi Yamada, Seiji Kojima

J Pediatr Hematol Oncol   Vol. 35 ( 5 ) page： 219-223   2013.7

Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules.

Akihiro Mouri,Taku Nagai,Daisuke Ibi,Kiyofumi Yamada.

Neurobiol Dis.   Vol. 53   page： 61-74   2013.5

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.

Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K

Glia   Vol. 61   page： 679-693   2013.5

Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in sic different time-windows.

Alkam T,Kim HC,Hiramatsu M,Mamiya T,Aoyama Y,Nitta A,Yamada K,Nabeshima T.

Behav Brain Res.   Vol. 239   page： 80-89   2013.2

Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and reapse in mice.

Yan Y,Miyamoto Y,Nitta A,Muramatsu SI,Ozawa K,Yamada K,Nabeshima T.

Int J Neuropsychopharmacol.   Vol. 22   page： 1-9   2013.2

Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats.

Zhang L,Nagai T,Yamada K,Ibi D,Ichihara S,Subramanian K,Huang Z,Mohideen SS,Naito H,Ichihara G.

Toxicology   Vol. 304   page： 76-82   2013.2

Neuronal PAS domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I.

Jaesuk Yun,Taku Nagai,Yoko Furukawa-Hibi,Keisuke Kuroda ,Kozo Kaibuchi,Michael E.Greenberg,Kiyofumi Yamada.

J Bio Chem.   Vol. 288 ( 4 ) page： 2655-64   2013.1

SHATI/NAT8L Regulates Neurite Outgrowth Via Microtubule Stabilization.

Kazuya Toriumi,Miki Ikami,Mizuki Kondo,Akihiro Mouri,Takenao Koseki,Daisuke Ibi,Yoko Furukawa-Hibi,Taku Nagai,Takayoshi Mamiya,Atsumi Nitta,Kiyofumi Yamada,Toshitaka Nabeshima.

Journal of Neuroscience Research91.     page： 1525-1532   2013

The risk factors of severe acute kidney injury induced by cisplatin.

Mizuno T, Ishikawa K, Sato W, Koike T, Kushida M, Miyagawa Y, Yamada K, Hirata S, Imai E, Noda Y

Oncology   Vol. 85   page： 364-369   2013

Transcriptional suppression of the neuronal PAS domain 4(Npas 4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter.

Furukawa-Hibi Y,Yun J,Nagai T,Yamada K,

J Neurochem.   Vol. 123 ( 5 ) page： 866-875   2012.12

Reliability and Validity of the Japanese Version of BEMIB Modified for Patients With Bipolar Disorder: a Self-rating Scale for Medication Adherence.

Tokura T,Kimura H,Yoshimi A,Ohashi M,Masuda M,Senzaki K,Yoshida K,Aleksic B,Noda Y,Yamada K,Ozaki N.

CNPT(Clinical Neuropsychopharmacology and Therapeutics.     page： 26-32   2012.12

Dopamine release via the vacuolar ATPase V0 sector c-subunit,confirmed in N18 neuroblastoma cells,results in behavioral recovery in hemiparkinsonian mice.

Jin D,Muramatsu S,Shimizu N,Yokoyama S,Hirai H,Yamada K,Liu HX,Higashida C,Hashii M,Higasida A,Asano M,Ohkuma S,Higasida H.

Neurochem Int.   Vol. 61 ( 6 ) page： 907-12   2012.11

D-serine ameliorates neonatal poly I:C treatment-induced emotional and cognitive impairments in adult mice.

Nagai T,Yu J,Kitahara Y,Nabeshima T,Yamada K.

Neuropharmacology   Vol. 120 ( 3 ) page： 213-227   2012.11

Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomy in elderly patients.

Mizuno T, Ito K, Miyagawa Y, Ishikawa K, Suzuki Y, Mizuno M, Ito Y, Funahashi Y, Hattori R, Gotoh M, Yamada K, Noda Y

Jpn J Clin Oncol.   Vol. 42   page： 1073-1078   2012.11

Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomaized mice.

Takuma K, Mizoguchi H, Funatsu Y, Kitahara Y, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T, Yamada K

J. Pharmacol. Sci.   Vol. 120   page： 89-97   2012.10

Absence of SHATI/Nata81 reduces social interaction in mice.

Yoko Furukawa-Hibi,Atsumi Nitta,Hidefumi Fukumitsu,Hitomi Somiya,Kazuya Toriumi,Shoei Furukawa,Toshitaka Nabeshima,Kiyofumi Yamada.

Neuroscience Lettters   Vol. 526 ( 2 ) page： 79-84   2012.9

Pharmacist-based Donepezil Outpationt Consultation Service to improve medication persistence.

Watanabe N,Yamamura K,Suzuki Y,Umegaki H,Shigeno K,Matsushita R,Sai Y,Miyamoto K,Yamada K.

Patient Prefer Adherence.   Vol. 6   page： 605-11   2012.9

Repeated tretment with nicotine induced phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization.

Nakajima A,Kinupasa Y,Torii J,Hishinuma T,Tomioka Y,Yamada K,Yamakuni T.

Neurosci Lett.   Vol. 524 ( 2 ) page： 133-138   2012.8

Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia.

Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Esaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S.

Blood.   Vol. 120   page： 1485-1488   2012.8

Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice.

Yan Y,Nitta A,Koseki T,Yamada K,Nabeshipa T

Psychopharmacology(Berl.)   Vol. 221 ( 3 ) page： 427-36   2012.6

Effect of shingle therapeutic doses of promethzine,fexofenadine and olopatadine on psychomotor function and histamine-induced wheal-and flare-responses:a randomized double-blind,placebo-controlled study in healthy volunteers.

Kamei H,Isaji A,NodaY,Ishikawa K,Senzaki K,Yamada K,Tomita Y,Nabeshima T

Arch Dematol Res   Vol. 304 ( 4 ) page： 263-72   2012.5

Involvement of matrix metalloproteinases-9 in the development of morphine tolerance.

Nakamoto K,Kawasaki S,Kobori T,Fujita-Hamabe W,Mizoguchi H,Yamada K,Nabeshima T,Tokuyama S.

Eur J Pharmacol.   Vol. 683 ( 1-3 ) page： 86-92   2012.5

Nobiletin,a citrus flavonoid,ameliorates cognitive impairment,oxidative burden,and hyperphosphorylation of tau in senescence-accelerated mouse.

Akira Nakajima,Yuki Aoyama,Thuy-Ty Lan Nguyen,Eun Joo Shin,Hyoung-Chun Kim,Shinnosuke Yamada,Tsuyoshi Nakai,Taku Nagai,Akihiro Yokosuka,Yoshihiro Mimaki,Yasushi Ohizumi,Kiyofumi Yamada.

Behavioural Brain Research Pii.   Vol. S0166-4328 ( 13 ) page： 00304-5   2012.5

Protective potentioal of IL-6 against trimethyltin-induced neurotoxicity in vivo.

Tran HY,Shin EJ,Saito K,Nquyen XK,Chung YH,Jeong JH,Park DH,Yamada K,Nabeshima T,Yoneda Y,Kim HC

Free Radic.Bio.Med.   Vol. 52 ( 7 ) page： 1159-1174   2012.4

Combination of Chronic Stress and Ovariectomy Causes Conditioned Fear Memory Deficites and Hippocampal Cholinergic Neuronal Loss in Mice

Takuma K,Mizoguchi H,Funatsu Y,Hoshina Y,Himeno Y,Fukuzaki E,Kitahara Y,Arai S,Ib D,Kamei H,Matsuda K,Koike K,Inoue M,Nagai T,Yamada K.

Neuroscience   Vol. 207   page： 261-73   2012.4

MEGA-D1 Regulates Expression of Depression-Like Behavior through Serotonin Transporter Ubiquitylation.

Mouri A,Sasaki A,Watanabe K,Sogawa C,Kitayama S, Mamiya T,Miyamoto Y,Yamada K,Noda Y,Nabeshima T.

J Neurosci.   Vol. 32 ( 13 ) page： 0   2012.3

Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome

Iriyama C,Tomita A,Hoshino H,Adachi-Shirahata M,Furukawa-Hibi Y,Yamada K,Kiyoi H, Naoe T.

Biophys Res Commun.   Vol. 419 ( 4 ) page： 662-9   2012.3

Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model.

Kato H, Mizuno T, Mizuno M, Sawai A, Suzuki Y, Kinashi H, Nagura F, Maruyama S, Noda Y, Yamada K, Matsuo S, Ito Y.

Nephrol. Dial. Transplant.   Vol. 27   page： 526-536   2012.2

Renal impairment after laparoscopic radical nephrectomy affects hypoglycaemic therapy.

Mizuno T, Ito K, Miyagawa Y, Kimura K, Suzuki Y, Mizuno M, Ito Y, Funahasi Y, Hattori R, Gotoh M, Noda Y, Yamada K

J Clinic. Pharm. Therapeu.   Vol. 37   page： 49-52   2012.2

KDIGO criteria could be useful outcome predictor of cisplatin-induced acute kidney injury.

Mizuno T,Sato W,Ishikawa K,Shinjo H,Miyagawa Y,Noda Y,Imai E,Yamada K.

Oncology   Vol. 82 ( 6 ) page： 354-359   2012

Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines.

Nawa H, Yamada K

Psychiatric Disorders: Methods and Protocols.     2012

Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy.

Mizoguchi H, Yamada K, Nabeshima T

Biochem. Res. Internat.     2011.12

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the DISC1 gene in the mouse.

Kuroda K, Yamada S, Tanaka, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K, Kaibuchi K

Hum. Mol. Genet.   Vol. 20   page： 4666-4683   2011.12

Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-beta peptide in mice.

Furukawa-Hibi Y, Alkam T, Nitta A, Matsuyama A, Mizoguchi H, Suzuki K, Moussaoui S, Yu Q-S, Greig NH, Nagai T, Yamada K

Behav Brain Res.   Vol. 225   page： 222-229   2011.11

Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment.

Nagai T, Kitahara Y, Ibi D, Nabeshima T, Sawa A, Yamada K

Behav. Brain Res.   Vol. 225   page： 305-310   2011.11

Animal Model For Schizophrenia That Reflects Gene-Environment Interactions.

Taku Nagai, Daisuke Ibi and Kiyofumi Yamada

Biological & Pharmaceutical Bulletin   Vol. 34 ( 9 ) page： 1364-1368   2011.9

Translational research in neurodevelopmental disorders: Development of etiology-based animal models foreword.

Yamada K

Biol. Pharm. Bull.   Vol. 34   page： 1357   2011.9

Relationship between hematotoxicity and serum albumin level in the Treatment of head and neck cancers with concurrent chemoradiotherapy using cisplatin.

Ishizuka M, Fujimoto Y, Itoh Y, Sano M, Miyagawa Y, Ando A, Hiramatsu M, Hirasawa N, Ishihara S, Nabeshima T, Yamada K.

Jpn. J. Clin. Oncol.   Vol. 41   page： 973-979   2011.8

Nicotine ameliorates impairment of working memory in methamphetamine-treated rats.

Mizoguchi H, Ibi D, Takase F, Nagai T, Kamei H, Toth E, Sato J, Takuma K, Yamada K

Behav Brain Res.   Vol. 220 ( 1 ) page： 159-163   2011.7

Matrix metalloproteinase-9 contributes to kindlined seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.

Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K

J Neurosci   Vol. 31   page： 12963-12971   2011.7

The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF.

Furukawa-Hibi Y, Nitta A, Ikeda T, Morishita K, Liu W, Ibi D, Alkam T, Nabeshima T, Yamada K

Behav Brain Res.   Vol. 220   page： 271-280   2011.7

Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage.

Shichi K,Fujita-Hamane W,Harada S,Mizoguchi H,Yamada K,Nabeshima T,Tokuyama S

J Pharmacol ExpTher.   Vol. 332 ( 2 ) page： 701-10   2011.5

Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy.

Wakasaya Y,Kawarabayashi T,Watanabe M,Yamamoto-Watanabe Y,Takamura A,Kurata T,MurakamiT,Abe K,Yamada K,Wakabayashi K,Sasaki A,Westaway D,Hyslop PS,Matsubara E,Shoji M.

J Neurosci Res.   Vol. 89 ( 4 ) page： 576-84   2011.4

Effects of Gastrodia Bl on Phencycline-Induced Schizophrenia-Like psychosis in Mice.

E-J. Shin, J-M. Kim, X-K T Nguyen, T-T L Nguyen, S Y Lee, J-H Jung, M J Kim, W K Whang, K Yamada, T Nabeshima and H-C Kim

Current Neuropharmacology   Vol. 9   page： 245-250   2011.3

Pharmacologic treatment with GABA(B) receptor agonist on methamphetamine-induced cognitive impairment in mice.

Mizoguchi H, Yamada K

Curr. Neuropharmacol.   Vol. 9   page： 109-112   2011.3

Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation. Reviewed

Mizuno T, Mizuno M, Morgan BP, Noda Y, Yamada K, Okada N, Yuzawa Y, Matsuo S, Ito Y

Nephrol Dial Transplant   Vol. 26 ( 6 ) page： 1821-1830   2011.1

Evaluation of object-based attention in mice. Reviewed

Alkam T, Hiramatsu M, Mamiy T, Aoyama A, Nitta A, Yamada K, Kim HC, Nabeshima T

Behav Brain Res.   Vol. 220 ( 1 ) page： 185-193   2011.1

Matrix metalloproteinase-9 contributes to kindlined seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.

Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K

J Neurosci.   Vol. 31   page： 12963-12971   2011

Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty. Reviewed

Miyagawa Y, Ejiri M, Kuzuya T, Osada T, Ishiguro N and Yamada K

J. Clin. Pharm. Ther.   Vol. 35 ( 6 ) page： 679-684   2010.12

Overexpression of piccolo C2A domain induces depression-like behavior in mice. Reviewed

Furukawa-Hibi Y, Nitta A, Fukumitsu Y, Somiya H, Furukawa S, Nabeshima T, and Yamada K

Neuroreport   Vol. 21 ( 18 ) page： 1177-1181   2010.12

Gene-wide association study between methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population with an updated meta-analysis on currently available data.

Yoshimi A, Aleksic B, Kawamura Y, Takahashi N, Yamada S, Usui H, Saito S, Ito Y, Iwata N, Inada T, Noda Y, Yamada K, Ozaki N

Schizophr. Res.   Vol. 124   page： 216-222   2010.12

Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems.

Noda Y, Mouri A, Ando Y, Waki Y, Yamada SN, Yoshimi A, Yamada K, Ozaki N, Wang D, Nabeshima T

Int J Neuropsychopharmacol.   Vol. 11   page： 1-12   2010.11

Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4.

Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, Yoneyama M, Ogita K, Yoneda Y, Nabeshima T, Nagai T, Yamada K

J. Neurochem   Vol. 114 ( 6 ) page： 1840-1851   2010.9

Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase.

Alkam T, Nitta A, Furukawa-Hibi Y, Niwa M, Mizoguchi H, Yamada K, Nabeshima T

Behav Brain Res.   Vol. 210 ( 2 ) page： 184-190   2010.7

Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT(1A) Receptor.

Shin EJ, Whang WK, Kim S, Bach JH, Kim JM, Nguyen XK, Nguyen TT, Jung BD, Yamada K, Nabeshima T, Kim HC

J. Pharmacol Sci.   Vol. 113 ( 4 ) page： 404-408   2010.7

Cytokine Receptor-Like Factor 1 is Highly Expressed in Damaged Human Knee Osteoarthritic Cartilage and Involved in Osteoarthritis Downstream of TGF-beta.

Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, Hara T, Ishibashi H, Koshihara Y, Yamada K, Yoneda Y:

Calcified Tissue Int.   Vol. 86   page： 47-57   2010.6

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Reviewed

Ohki M, Ohki Y, Akiyama H, Ishihara M, Nishida C, Komiyama H, Lund LR, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Werb Z, Heissig B, Hattori K

Blood.   Vol. 115 ( 21 ) page： 4302-4312   2010.5

Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy.

Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G

J Neurosci.   Vol. 30 ( 16 ) page： 5702-5712   2010.4

Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment.

Lu P, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, Zou L B, Nagai T, Yamada K, Ikejima T, Nabeshima T

Behav Brain Res.   Vol. 207 ( 2 ) page： 387-393   2010.3

Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: An in vivo microdialysis study.

Nagai T, Kitahara Y, Shiraki A, Hikita T, Taya S, Kaibuchi K, Yamada K

Neurosci.Lett   Vol. 470 ( 2 ) page： 134-138   2010.2

Cytokine receptor-like factor 1 is highly expressed in damaged human knee OA cartilage and is involved in OA downstream of TGF-β.

Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, Toshifumi Hara T, Ishibashi H, Koshihara Y, Yamada K, Yoneda Y

Calcif Tissue Int.   Vol. 86 ( 1 ) page： 47-57   2010.1

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Reviewed

Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, and Yamada K

Behav. Brain Res.   Vol. 206 ( 1 ) page： 32-37   2010.1

Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice.

Mizoguchi H, Ibi D, Takuma K, Toth E, Sato J, Itohara S, Nabeshima N, Yamada K

The Open Behavioral Science Journal.   Vol. 4   page： 19-25   2010

Nicotine ameliorates emotional and cognitive impairments induced by neonatal polyI:C treatment in mice.

Yu J, Nagai T, Ibi D, Kitahara Y, Nabeshima T, Yamada K

The Open Behavioral Science Journal.   Vol. 4   page： 9-18   2010

A survey of antipsychotic polypharmacy in outpatients at Nagoya University Hospital. Reviewed

Yoshimi A, Noda Y, Aleksic B, Senzaki K, Ohashi M, Yamada S, Yamada K and Ozaki N

Clinical Neuropsychopharmacology and Therapeutics     page： 43-49   2010

Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons. Reviewed

Mizoguchi H, Arai S, Koike H, Ibi D, Kamei H, Nabeshima T, Kim HC, Takuma K ,Yamada K.

Psychopharmacology   Vol. 207 ( 2 ) page： 235-243,   2009.12

Role of microsomal epoxide hydrolase in methamphetamine-induced drug dependence in mice Reviewed

Shin EJ, Bing G, Chae JS, Kim TW, Bach JH, Park DH, Yamada K, Nabesima T, Kim HC

J Neurosci Res.   Vol. 87 ( 16 ) page： 3679-86.   2009.12

Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairment. Reviewed

Jin CH, Shin EJ, Park JB, Jang CG, Li Z, Kim MS, Koo KH, Yoon HJ, Park SJ, Choi WC, Yamada K, Nabeshima T and Kim HC

J. Neurosci. Res.   Vol. 87 ( 16 ) page： 3658-70.   2009.12

*RAGE-mdiated signaling contributes to intraneuronal transport of amyloid- and neuronal dysfunction. Reviewed

Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K and Yan SD

Proc Natl Acad Sci USA   Vol. 106 ( 47 ) page： 20021-20026   2009.11

An environmental and biological study of occupational exposure to cyclophosphamide in the pharmacy of a Japanese community hospital designated for the treatment of cancer. Reviewed

Tanimura M, Mori K, Nagata H, Tadokoro K, Miyake T, Hamaguchi Y, Sessink PJM, Sugiura S, Yamada K and Nabeshima T

J. Health Sci.   Vol. 55 ( 5 ) page： 750   2009.10

Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice. Reviewed

Shin EJ, Jang CG, Bing G, Park DH, Oh CH, Koo KH, Oh KW, Yamada K, Nabeshima T and Kim HC

Drug Alcohol Dependence.   Vol. 104 ( 1-2 ) page： 175-84.   2009.9

Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic condition. Reviewed

Otsuka N, Tsuritani K, Sakurai T, Kato K, Matoba R, Itoh J, Okuyama S, Yamada K and Yoneda Y

Brain Res   Vol. 1287 ( 136-145 )   2009.9

Population pharmacokinetic analysis of vancomycin in patients with gram-positive infections and the influence of infectious disease type. Reviewed

Yamamoto M, Kuzuya T, Baba H, Yamada K and Nabeshima T

J. Clin. Pharm. Ther.   Vol. 34 ( 4 ) page： 473-83.   2009.8

Behavioral abnormality and phamacologic response in social isolation-reared mice. Reviewed

Koike H, Ibi D, Mizoguchi H, Nagai T, Nitta A, Takuma K, Nabeshima T, Yoneda Y, Yamada K.

Behav. Brain Res.   Vol. 202   page： 114–121   2009.8

Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood. Reviewed

Ibi D, Nagai T, Kitahara Y, Mizoguchi H, Koike H, Shiraki A, Takuma K, Kamei H, Noda N, Nitta A, Nabeshima T, Yoneda Y and Yamada K

Neurosci. Res.   Vol. 64   page： 297-305   2009.7

The latent risk of acidosis in commercially available total parenteral nutrition (TPN)products: a randomized clinical trial in postoperarative patients Reviewed

Katsuyoshi Kato, Shin-ichi Sugiura, Kohji Yano, Toshio Fukuoka, Akio Itoh, Masato Nagino, Toshitaka Nabeshima, Kiyofumi Yamada.

J.Clin.Biochem.Nutr.   Vol. 45 ( 68-73 )   2009.7

Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly. Reviewed

168 Gu B, Nakamichi N, Zhang WS, Nakamura Y, Kambe Y, Fukumori R, Takuma K, Yamada K, Takarada T, Taniura H and Yoneda Y

J. Neurosci. Res.   Vol. 87 ( 2145-2156 )   2009.7

Matrix metalloprotease-9 inhibition improves amyloid b-mediated cognitive impairment and neurotoxicity in mice. Reviewed

Mizoguchi H, Takuma K, Fukuzaki E, Ibi D, Someya E, Akazawa K, Alkam T, Tsunekawa H, Mouri A, Noda Y, Nabeshima T and Yamada K

J. Pharmacol. Exp. Ther.   Vol. 331   page： 14-22   2009.7

The chondroprotective agent ITZ-1 inhibits interleukin-1β-induzced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death Reviewed

Kimura H, Yukitake H, Suzuki H, Tajima Y, Gomaibashi K, Morimoto S, Funabashi Y, Yamada K, Takizawa M

J. Pharmacol. Sci.   Vol. 110 ( 201-211 )   2009.6

Antiamnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid β25-35 -induced toxicity in mice. Reviewed

Villard V, Espallergues J, Keller E, Alkam T, Nitta A, Yamada K, Nabeshima, T, Vamvakides A and Maurice T

Neuropsychopharmacology   Vol. 34   page： 1552-1566   2009.5

Evaluation of interleukin-2 mRNA in whole blood as a parameter for monitoring cyclosporine pharmacodynamics. Reviewed

Kuzuya T, Kobayashi T, Katayama A, Nagasaka T, Miwa Y, Uchida K, Nakao A and Yamada K

Biol. Pharm. Bull.   ( 32 ) page： 604-608   2009.4

Pharmacodynamicsを用いた代謝拮抗薬およびmTOR阻害薬の薬効評価 Reviewed

水野加代子,葛谷孝文,加藤真梨奈，倉田洋子，岩崎研太, 野田幸裕，網岡克雄，山田清文，小林孝彰

愛知県病院薬剤師会雑誌   Vol. 36 ( 4 )   2009.4

痛みの表現に基づく痛みの評価　―肺がん患者における痛みの表現と原因との関連性の検討―． Reviewed

稲垣聡美、宮崎雅之、加藤勝義、手塚智子、長谷川好規、鍋島俊隆、野田幸裕、山田清文

日本緩和医療薬学雑誌     page： 65-73   2009.2

外来喘息教室における薬剤師の役割とその効果について Reviewed

倉田洋子，岸里奈，山田真之亮，長谷川雅哉，山田清文，久米裕昭，長谷川好規，鍋島俊隆，野田幸裕

医療薬学   Vol. 35   page： 145-151   2009.2

GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice. Reviewed

Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Kamei H, Kim HC and Yamada K

Eur. J. Pharmacol.   Vol. 602   page： 101-104   2009.1

Growth hormone–releaser diet attenuates β-amyloid(1-42)–induced cognitive impairment via stimulation of the insulin-like growth factor (IGF)-1 receptor in mice. Reviewed

Shin EJ, Chae JS, Park SJ, Kim SC, Koo KH, Yamada K, Nabeshima T and Kim HC:

J. Pharmacol. Sci.   ( 109 ) page： 139-143   2009.1

ドーパミン神経系と意思決定：薬物依存者における機能障害. Reviewed

山田清文

臨床精神医学   Vol. 38   page： 印刷中   2009

Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice. Reviewed

Mizoguchi H, Takuma K, Fukakusa A, Ito Y, Nakatani A, Ibi D, Kim HC and Yamada K

Psychopharmacology   Vol. 196   page： 233-241   2008

Documenting the value of a pharmacist-managed anticoagulation classroom. Reviewed

Yano K, Yamamura K, Osada T, Fukase F, Kiriyama N, Torimoto M, Yamada K, Kishi DT and Nabeshima T

J. Appl. Ther. Res.   Vol. 6   page： 41-48   2008

Restraining tumor necrosis factor-alpha by thalidomide prevents the Abeta-induced impairment of recognition memory in mice. Reviewed

Alkam T, Nitta A, Mizoguchi H, Saito K, Seshima M, Itoh A, Yamada K and Nabeshima T

Behav. Brain Res.   Vol. 189   page： 100-106   2008

Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens. Reviewed

Fukakusa A, Nagai T, Mizoguchi H, Otsuka N, Kimura H, Kamei H, Kim H-C, Nabeshima T, Takuma K and Yamada K

J. Neurochem.   Vol. 105   page： 436-444   2008

造影剤使用による腎機能障害～造影剤腎症～. Reviewed

水谷佳代, 加藤博史, 山田清文, 野田幸裕, 鍋島俊隆

愛知県病院薬剤師会雑誌   Vol. 36 ( 1 ) page： 2-6   2008

成人の喘息‐薬剤師によるファーマシューティカルケア外来. Reviewed

長谷川雅哉, 鍋島俊隆, 山田清文

薬事   Vol. 50   page： 389-393   2008

米国ノースカロライナ大学における臨床薬学教育． Reviewed

石塚雅子，山田清文，鍋島俊隆

日本病院薬剤師会雑誌   Vol. 44   page： 297-302   2008

薬物依存に関与するサイトカイン・プロテアーゼの動態および機能解析. Reviewed

山田清文

日本神経精神薬理学雑誌   Vol. 28   page： 195-201   2008

組織プラスミノーゲン活性化因子による依存性薬物の報酬効果の制御． Reviewed

永井拓，田熊一敞，鍋島俊隆，山田清文

日本神経精神薬理学雑誌   Vol. 28   page： 1-6   2008

ニコチン依存における組織プラスミノーゲン活性化因子の役割．

永井拓，山田清文

日本アルコール・薬物医学会雑誌   Vol. 43   page： 151-157   2008

抗真菌薬と免疫抑制薬‐併用における留意点.

太田小織, 山田清文

深在性真菌症～SFI Forum～   Vol. 4   page： 25-27   2008

婦人科がん化学療法による嘔気・嘔吐の改善に向けたプロトコールの見直し. Reviewed

川村由季子, 手塚智子, 桐山典子, 石川和宏, 山田清文, 鍋島俊隆, 野田幸裕

医薬ジャーナル   Vol. 44   page： 2435-2440   2008

Basic and translational research on proteinase-activated receptors: Regulation of nicotine reward by the tissue plasminogen activator (tPA) – plasmin system via proteinase-activated receptor 1. Reviewed

Nagai T, Nabeshima T and Yamada K

J. Pharmacol. Sci.   Vol. 108   page： 408-414   2008

Role for anti-addictive and pro-addictive factor in drug dependence. Invited Reviewed

Yamada K

Nagoya J. Med. Sci.   Vol. 70   page： 67-72   2008

Neuropsychotoxicity of Abused Drugs: Involvement of matrix metalloproteinase-2 and -9, and tissue inhibitor of matrix metalloproteinase-2 in methamphetamine-induced behavioral sensitization and reward in rodents. Reviewed

Mizoguchi H, Yamada K and Nabeshima T

J. Pharmacol. Sci.   Vol. 106   page： 9-14   2008

Neuropsychotoxicity of abused drugs: Clinical and basic research and drug development: Preface. Reviewed

Yamada K and Kaneko S

J. Pharmacol. Sci.   Vol. 106   page： 1   2008

Endogenous modulators for drug dependence. Reviewed

Yamada K

Biol. Pharm. Bull.   Vol. 31   page： 1635-1638   2008

ステロイド剤が導入された婦人科がん化学療法レジメンの評価. Reviewed

桐山典子，手塚智子，川村由季子，石川和宏，野田幸裕，鍋島俊隆，山田清文

日本緩和医療薬学雑誌   Vol. 1   page： 47-52   2008

Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload. Reviewed

Kanazawa Y, Makino M, Morishima Y, Yamada K, Nabeshima T and Shirasaki Y

Neuroscience   Vol. 154   page： 473-481   2008

Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits. Reviewed

Fukuzaki E, Takuma K, Himeno Y, Yoshida S, Funatsu Y, Kitahara Y, Mizoguchi H, Ibi D, Koike K, Inoue M and Yamada K

Neurosci. Lett.   Vol. 433   page： 141-145   2008

Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen. Reviewed

Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Takahashi K, Kamei H, Nabeshima T and Yamada K

Neuropsychopharmacology   Vol. 33   page： 3164-3175   2008

Ovariectomy increases neuronal amyloid β binding alchohol dehydrogenease level in the mouse hippocampus. Reviewed

Fukuzaki E, Takuma K, Funatsu Y, Himeno Y, Kitahara Y, Gu B, Mizoguchi H, Ibi D, Koike K, Inoue M, Yan SD and Yamada K

Neurochem. Int.   Vol. 52   page： 1358-1364   2008

Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. Reviewed

Fukakusa A, Mizoguchi H, Koike H, Nabeshima T, Takuma K and Yamada K

J. Pharmacol. Sci.   Vol. 106   page： 321-324   2008

The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid β in mice. Reviewed

Alkam T, Nitta A, Mizoguchi H, Itoh A, Murai R, Nagai T, Yamada K and Nabeshima T

J. Pharmacol. Exp. Ther.   Vol. 27   page： 137-147   2008

Production and functions of IL-17 in microglia. Reviewed

Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H and Suzumura A

J. Neuroimmunol.   Vol. 194   page： 54-61   2008

A novel molecule `shati' increases dopamine uptake via the induction of tumor necrosis factor-α in pheochromocytoma-12 cells. Reviewed

Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K and Nabeshima T

J. Neurochem.   Vol. 107   page： 1697-1708   2008

Tamaki K, Yamada K, Nakamichi N, Taniura H and Yoneda Y Reviewed

Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience.

J. Neurochem.   Vol. 105   page： 1642-1655   2008

Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. Reviewed

Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, Kamei H, Nagai T, Yoneda Y, Nabeshima T and Yamada K

J. Neurochem.   Vol. 105   page： 921-932   2008

Transient drug-primed but persistent cue-induced reinstatement of extinguished methamphetamine-seeking behavior in mice. Reviewed

Yan Y, Yamada K, Nitta A and Nabeshima T

Behav. Brain Res.   Vol. 177   page： 261-268   2007

Activation of postsynaptic dopamine D1 receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling. Reviewed

Ito M, Nagai T, Mizoguchi H, Sato K, Hayase M, Otsuka N, Nabeshima T, Takuma K and Yamada K.

J. Neurochem.   Vol. 103   page： 2589-2596   2007

Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9 deficient mice. Reviewed

Mizoguchi H, Yamada K, Niwa M, Mouri A, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T

J. Neurochem.   Vol. 100   page： 1579-1588   2007

Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue-plasminogen activator-plasmin system. Reviewed

Ito M, Nagai T, Mizoguchi H, Fukakusa A, Nakanishi Y, Kamei H, Nabeshima T, Takuma K and Yamada K

J. Neurochem.   Vol. 101   page： 1392-1399   2007

Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine. Reviewed

Maeda K, Sugino H, Hirose T, Kitagawa H, Nagai T, Mizoguchi H, Takuma K and Yamada K

J. Pharmacol. Sci.   Vol. 103   page： 299-308   2007

Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. Reviewed

Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T and Kim HC:

J. Pharmacol. Sci.   Vol. 105   page： 367-371   2007

A dibenzoylmethane (DBM) derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum (ER) stress. Reviewed

Takano K, Kitao Y, Tabata Y, Miura H, Sato K, Takuma K, Yamada K, Hibino S, Choshi T, Iinuma M, Suzuki H, Murakami R, Yamada M, Ogawa S and Hori O

Am. J. Physiol. Cell Physiol.   Vol. 293   page： 1884-1894   2007

The roles of glia cell-derived neurotrophic factor, tumor necrosis factor-a, and an inducer of them in drug dependence.

Niwa M, Nitta A, Yamada K and Nabeshima T

J. Pharmacol. Sci.   Vol. 104   page： 116-121   2007

放射状迷路を用いたDelayed spatial win-shift課題による空間作業記憶の評価（実験技術）．

永井拓、田熊一敞、亀井浩行、溝口博之、鍋島俊隆、山田清文

日本薬理学雑誌   Vol. 129   page： 457-462   2007

Repeated methamphetamine impairs spatial working memory in rats: reverasal by clozapine but not haloperidol. Reviewed

Nagai T, Takuma K, Dohniwa M, Ibi D, Mizoguchi H, Kamei H, Nabeshima T and Yamada K

Psychopharmacology   Vol. 194   page： 21-32   2007

Ginkgo bioba extract EGb761 improve hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats. Reviewed

Takuma K, Hoshina, Y, Himeno Y, Arai S, Matsuo, A, Funatsu Y, Ibi, D, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K

Neuroscience   Vol. 149   page： 256-262   2007

Reinforceing effects of morhine are reduced in tissue plasminogen activator (tPA)-knockout mice. Reviewed

Yan Y, Yamada K, Mizoguchi H, Noda Y, Nagai T, Nitta A and Nabeshima T

Neuroscience   Vol. 146   page： 50-59   2007

Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-OHDA-induced hemi-Parkinsonian mouse model. Reviewed

Matsuya T, Takuma K, Sato K, Asai M, Murakami Y, Miyoshi S, Noda A, Nagai T, Mizoguchi H, Nishimura S and Yamada K

J. Pharmacol. Sci.   Vol. 103   page： 329-332   2007

A novel azaindolizinone derivative ZSET1446, spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one, improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2. Reviewed

Ito Y, Takuma K, Kamei Y, Mizoguchi H, Nagai T and Yamada K

J. Pharmacol. Exp. Ther.   Vol. 320   page： 819-827   2007

Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: Implication for dopamine receptor downregulation and dopamine release. Reviewed

Mizoguchi H, Yamada K, Mouri A, Niwa M, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T

J. Neurochem.   Vol. 102   page： 1548-1560   2007

Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice. Reviewed

Yan Y, Yamada K, Niwa M, Nagai T, Nitta A and Nabeshima T.

FASEB J.   Vol. 21   page： 1994-2004   2007

17b-Estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. Reviewed

Takuma K, Matsuo A, Himeno Y, Hoshina Y, Ohno Y, Funatsu Y, Arai S, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K

Neuroscience   Vol. 146   page： 60-68   2007

Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex. Reviewed

Nagai T, Takuma K, Kamei H, Ito Y, Nakamichi N, Ibi D, Nakanishi Y, Murai M, Mizoguchi H, Nabeshima T and Yamada K

Lean Mem.   Vol. 14   page： 117-125   2007

CD38 is critical for social behavior by regulating oxytocin secretion. Reviewed

Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatia O, Shnayder NA, Yamada K, Noda M, Seike T, Tujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi M, Tanaka S, Hashi M, Yoshihara T, Hidashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M and Higashida H

Nature   Vol. 446   page： 41-45   2007

Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice. Reviewed

Takahashi K, Nagai T, Kamei H, Maeda K, Matsuya T, Arai S, Mizoguchi H, Yoneda Y, Nabeshima T, Takuma K and Yamada K

Biol. Psychiatry   Vol. 62 ( 2 ) page： 148-157   2007

学習・記憶行動の評価法． Reviewed

田熊一敞，永井拓，山田清文

日本薬理学雑誌   Vol. 130   page： 112-116   2007

Involvement of hippocampal ERK1/2 in spatial working memory in rats. Reviewed

Nagai T, Kamei H, Dohniwa M, Takayanagi M, Suzuki M, Matsuya T, Nabeshima T, Takuma K and Yamada K

NeuroReport   Vol. 17   page： 1453-1457   2006

a7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in b-amyloid infused rats. Reviewed

Chen L, Yamada K, Nabeshima T and Sokabe M

Neuropharmacology   Vol. 50   page： 254-268   2006

The magnetism responsive gene Ntan1 in mouse brain. Reviewed

Goto Y, Taniura H, Yamada K, Hirai T, Sanada N, Nakamichi N and Yoneda Y

Neurochem. Int.   Vol. 49   page： 334-341   2006

Effect of fructose-rich high fat diet on glucose sensitivity and atherosclerosis in non-human primate. Reviewed

Suzuki M, Yamamoto D, Suzuki T, Fujii M, Suzuki N, Fujishiro M, Sakurai T and Yamada K

Methods Find. Exp. Clin. Pharmacol.   Vol. 28   page： 609-617   2006

High fat and high fructose diet induced intracranial atherosclerosis and enhanced vasoconstrictor responses in non-human primate. Reviewed

Suzuki M, Yamamoto D, Suzuki T, Fujii M, Suzuki N, Fujishiro M, Sakurai T and Yamada K

Life Sci.   Vol. 80   page： 200-204   2006

Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. Reviewed

Yoshida S, Maeda M, Kaku S, Hisao Ikeya H, Yamada K and Nakaike S

J Neural Transm.   Vol. 113   page： 1803-1814   2006

Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds. Reviewed

Yan Y, Nitta A, Mizuno T, Nakajima A, Yamada K and Nabeshima T

Behav. Brain Res.   Vol. 173   page： 39-46   2006

Relapse of methamphetamine-seeking behavior in C57BL/6J mice demonstrated by a reinstatement procedure involving intravenous self-administration. Reviewed

Yan Y, Nitta A, Mizoguchi H, Yamada K and Nabeshima T

Behav. Brain Res.   Vol. 168   page： 137-143   2006

Effects of single and repeated administration of methamphetamine or morphine on neuroglycan C gene expression in the rat brain. Reviewed

Ishikawa K, Nitta A, Mizoguchi H, Mohri A, Murai R, Miyamoto Y, Noda Y, Kitaichi K, Yamada K and Nabeshima T

Int. J. Neuropsychopharmacol.   Vol. 9   page： 407-415   2006

中枢神経系のアポトーシスにおけるミトコンドリアの役割に関する研究．

田熊一敞，山田清文，松田敏夫

日本薬理学雑誌   Vol. 127   page： 349?354   2006

モルヒネ依存形成における組織プラスミノーゲン活性化因子の役割．

永井拓，鍋島俊隆，田熊一敞，山田清文

日本アルコール・薬物医学会雑誌   Vol. 41   page： 23-30   2006

覚せい剤により誘発される記憶障害―発症機構と薬物治療

山田清文

医学のあゆみ   Vol. 217   page： 1171-1173   2006

Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK 1/2 activation in the prefrontal cortex. Reviewed

Kamei H, Nagai T, Nakano H, Togan Y, Takayanagi M, Takahashi K, Kobayashi K, Yoshida S, Maeda K, Takuma K, Nabeshima T and Yamada K

Biol. Psychiatry   Vol. 59   page： 75-84   2006

入院患者における末梢静脈カテーテルの閉塞に対するヘパリンロックの効果 Reviewed

郡司聖子、古川裕之、宮下知治、西村元一、安藤絹子、坂尾雅子、飛田敦子、山田清文、宮本謙一

医療薬学   Vol. 32   page： 87-95   2006

卵巣摘出ラットのストレス誘発性認知障害に対するラロキシフェンの効果 Reviewed

保科有希，小池浩司，姫野友紀子，鈴木信孝，村上弘一，田熊一敞，井上正樹，山田清文

日本更年期医学会雑誌   Vol. 14   page： 232-239   2006

*The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1. Reviewed

Nagai T, Ito M, Nakamichi N, Mizoguchi H, Kamei H, Fukakusa A, Nabeshima T, Takuma K and Yamada K

J. Neurosci.   Vol. 26   page： 12374-12383   2006

Involvement of tissue plasminogen activator-plasmin system in depolarization-evoked dopamine release in the nucleus accumbens of mice. Reviewed

Ito M, Nagai T, Kamei H, Nakamichi N, Nabeshima T, Takuma K and Yamada K

Mol. Pharmacol.   Vol. 70   page： 1720-1725   2006

Effects of memantine and donepezil on amyloid b-induced memory impairment in a delayed-matching to position task in mice. Reviewed

Yamada K, Takayanagi M, Kamei H, Nagai T, Dohniwa M, Kobayashi K, Yoshida S, Ohhara T, Takuma K and Nabeshima T

Behav. Brain Res.   Vol. 162   page： 191-199   2005

Aberrant expression and mutations of TGF-b receptor type II gene in endometrial cancer. Reviewed

Sakaguchi J, Kyo S, Kanaya T, Maida Y, Hashimoto M, Nakamura M, Yamada K and Inoue M

Gynecol. Oncol.   Vol. 98   page： 427-433   2005

覚せい剤および麻薬に共通する依存関連分子の検索

山田清文、永井拓、中島晶、鍋島俊隆

日本薬理学雑誌   Vol. 126   page： 49-53   2005

Mitochondrial dysfunction, endoplasmic reticulum stress and apoptosis in Alzheimer's disease.

Takuma K, Yan SS, Stern DM and Yamada K

J. Pharmacol. Sci.   Vol. 97   page： 312-316   2005

Drug dependence, synaptic plasticity, and tissue plasminogen activator.

Yamada K, Nagai T and Nabeshima T

J. Pharmacol. Sci.   Vol. 97   page： 157-161   2005

Amyloid pathology and protein kinase C (PKC): possible therapeutics effects of PKC activators.

Olariu A, Yamada K and Nabeshima T

J. Pharmacol. Sci.   Vol. 97   page： 1-5   2005

薬物依存と前頭前野

亀井浩行、野田幸裕、山田清文、鍋島俊隆

Clinical Neuroscience (臨床神経科学)   Vol. 23   page： 682-684   2005

脳と組織プラスミノーゲン活性化因子

永井拓、田熊一敞、山田清文

脳21   Vol. 8   page： 437-442   2005

グリア細胞の遅発性アポトーシス

田熊一敞、山田清文、松田敏夫

Clinical Neuroscience (臨床神経科学)   Vol. 23   page： 181-183   2005

遺伝子改変動物における情動性の評価

永井拓、山田清文、鍋島俊隆

日本薬理学雑誌   Vol. 125   page： 71-76   2005

Modification by the tissue plasminogen activator-plasmin system of morphine-induced dopamine release and dopamine-dependent hyperlocomotion, but not antinociceptive effect in mice. Reviewed

Nagai T, Kamei H, Ito M, Hashimoto K, Takuma K, Nabeshima T and Yamada K

J. Neurochem.   Vol. 93   page： 1272-1279   2005

ホルモン療法に抵抗を示す更年期の欝・不安症状に対する温経湯の有効性の検討 Reviewed

松尾亜伊、小池浩司、保科有希、村上弘一、井上正樹、大野智、鈴木信孝、山田清文、高橋紀子

産婦人科　漢方研究のあゆみ   Vol. 22   page： 70-74   2005

The role of tissue plasminogen activator in methmphetamine-related reward and sensitization. Reviewed

Nagai T, Noda Y, Ishikawa K, Miyamoto Y, Yoshimura Y, Ito M, Takayanagi M, Takuma K, Yamada K and Nabeshima T

J. Neurochem.   Vol. 92   page： 660-667   2005

Prostaglandin E receptor EP1 controls impulsive behavior under stress. Reviewed

Matsuoka Y, Furuyashiki T, Yamada K, Nagai T, Bito H, Tanaka Y, Kitaoka S, Ushikubi F, Nabeshima T and Narumiya S

Proc. Natl. Acad. Sci. USA   Vol. 102   page： 16066-16071   2005

The interaction between the cholinergic and dopaminergic system in learning and memory process in rats. Reviewed

Hefco V, Yamada K, Hefco A, Hritcu L, Tiron A, Nabeshima T.

Rom. J. Physiol.   Vol. 41   page： 21-30   2004

Expression of estrogen receptor-b in the postischemic monkey hippocampus. Reviewed

Takahashi N, Tonchev AB, Koike K, Murakami K, Yamada K, Yamashima T and Inoue M

Neurosci. Lett.   Vol. 369   page： 9-13   2004

Anatomical substrates for the discriminative stimulus effects of methamphetamine in rats. Reviewed

Nakajima A, Yamada K, He J, Zeng N, Nitta A and Nabeshima T

J. Neurochem.   Vol. 91   page： 308-317   2004

Enhanced antidepressant efficacy of s1 receptor agonist in rats after chronic intracerebroventricular infusion of b-amyloid-(1-40) protein. Reviewed

Urai A, Romieu P, Roman F, Yamada K, Noda Y, Kamei, H, Tran HM, Nagai T, Nabeshima T and Maurice T

Eur. J. Pharmacol.   Vol. 486   page： 151-161   2004

Efficacy of the herbal medicine Unkei-to as an adjunctive treatment to hormone replacement therapy for postmenopausal women with depressive symptoms. Reviewed

Koike K, Ohno S, Takahashi N, Suzuki N, Nozaki N, Murakami K, Sugiura K, Yamada K and Inoue M

Clin. Neuropharmacol.   Vol. 27   page： 157-162   2004

b-Amyloid(1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. Reviewed

Jhoo JH, Kim KC, Nabeshima T, Yamada K, Shin EJ, Jhoo WK, Kim W, Kang KS, Jo SA and Woo JI

Behav. Brain Res.   Vol. 155   page： 185-196   2004

Nefiracetam attenuates methamphetamine-induced discriminative stimulus effects in rats. Reviewed

Yan Y, Mizuno T, Nitta A, Yamada K, Nabeshima T

Ann. NY Acad. Sci.   Vol. 1025   page： 274-278   2004

Fos expression associated with the discriminative stimulus effects of methamphetamine in rats. Reviewed

Zeng N, Nakajima A, He J, Nitta A, Yamada K and Nabeshima T

Ann. NY Acad. Sci.   Vol. 1025   page： 236-241   2004

Pro- and anti-addictive neurotrophic factors and cytokines in psychostimulant addiction.

Yamada K and Nabeshima T

Ann. NY Acad. Sci.   Vol. 1025   page： 198-204   2004

Oxidative stress mechanism of amyloid b-peptide-induced impairment of neurotransmission and memory.

Nabeshima T, Tran MH, Kim KC and Yamada K

Method Find. Exp. Clin. Pharmacol.   Vol. 26   page： 1-3   2004

Interaction of BDNF/TrkB signaling and NMDA receptors in learning and memory.

Yamada K, Mizuno M and Nabeshima T

Drug News Perspect.   Vol. 17   page： 1-4   2004

Behavioral adaptations to addictive drugs in mice lacking NMDA receptor e1 subunit. Reviewed

Miyamoto Y, Yamada K, Nagai T, Mori, H, Mishina M, Furukawa H, Noda Y and Nabeshima T

Eur. J. Neurosci.   Vol. 19   page： 151-158   2004

*Tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release. Reviewed

Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto M, Hashimoto K, Noda Y, Nitta A and Nabeshima T

Proc. Natl. Acad. Sci. USA.   Vol. 101   page： 3650-3655   2004

Regulation of methamphetamine reward by extracellualr signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors. Reviewed

Mizoguchi H, Yamada K, Mizuno M, Mizuno T, Noda Y, Nitta A and Nabeshima T

Mol. Pharmacol.   Vol. 65   page： 1293-1301   2004

Role of TNF-a in methamphetamine-induced drug dependence and neurotocicity. Reviewed

Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC and Nabeshima T

J. Neurosci.   Vol. 24   page： 2212-2225   2004

Immunocytochemical evidence that b-amyloid (1-42) impairs endogenous antioxidant systems in vivo. Reviewed

Kim, HC, Yamada K, Olariu A, Tan MH, Jhoo WK, Im DH, Shin EJ, Park SC, Kato K, Hjelle OP, Mirault ME and Nabeshima T

Neuroscience   Vol. 119   page： 399-419   2003

新規老化促進モデルマウス、Klotho遺伝子変異マウスの認知障害

永井　拓、山田清文、鍋島陽一、鍋島俊隆

分子精神医学   Vol. 3   page： 62-63   2003

BDNF/TrkB signaling in memory processes.

Yamada K and Nabeshima T

J Pharmacol Sci.   Vol. 91   page： 267-270   2003

動物モデルからみた不安障害

亀井浩行、野田幸裕、鍋島俊隆、山田清文

最新精神医学   Vol. 8   page： 537-546   2003

Klotho遺伝子変異マウスの学習障害と酸化ストレス

永井　拓、山田清文、Hyoung Chun Kin、野田幸裕、鍋島陽一、鍋島俊隆

日本神経精神薬理学雑誌   Vol. 23   page： 211-217   2003

神経精神疾患におけるシグマ受容体リガンドの作用

亀井浩行、野田幸裕、鍋島俊隆、山田清文

日本神経精神薬理学雑誌   Vol. 23   page： 187-196   2003

薬物依存におけるサイトカインの役割について

中島　晶、山田清文、鍋島俊隆

日本神経精神薬理学雑誌   Vol. 23   page： 179-182   2003

グルタミン酸受容体の修飾と薬物依存

亀井浩行、山田清文、鍋島俊隆

分子精神医学   Vol. 3   page： 140-146   2003

大学院修士課程臨床薬学講義ならびに実務実習のVisual Analog Scale法による客観的評価 Reviewed

成橋和正、野村政明、亀井浩行、小野俊介、松下　良、清水　栄、横川弘一、山田清文、鈴木永雄、宮本謙一、木村和子

YAKUGAKU ZASSHI   Vol. 123   page： 973-980   2003

Neuronal mechanism of nociceptin-induced modulation of learning and memory: Involvement of N-methyl-D-aspartate receptors. Reviewed

Mamiya T, Yamada K, Miyamoto Y, Watanabe Y, Noda Y and Nabeshima T

Mol. Psychiat.   Vol. 8   page： 752-765   2003

*Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid b-peptide-induced cholinergic dysfunction. Reviewed

Tran MH, Yamada K, Nakajima A, Mizuno M, He J, Kamei H and Nabeshima T

Mol. Psychiat.   Vol. 8   page： 407-412   2003

Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Reviewed

Mizuno M, Yamada K, Takei N, Tran MH, He J, Nakajima A, Nawa H and Nabeshima T

Mol. Psychiat.   Vol. 8   page： 217-224   2003

Interaction of BDNF receptor TrkB and NMDA receptors in spatial memory formation. Reviewed

Mizuno M, Yamada K, He J, Nakajima A, Kawano Y, Makino K and Nabeshima T

Learn. Mem.   Vol. 10   page： 108-115   2003

Improvement in drug compliance by medical consultation at a pharmacist outpatients' clinic (Part 2). Reviewed

Maruyama T, Sugiura S, Kojima J, Arimasa Y, Satoh Y, Kanaji K, Matsumura T, Ohsumi K, Yamada K and Nabeshima T

J. Appl Therapeut. Res.   Vol. 4   page： 25-33   2003

Improvement in drug compliance by medical consultation at a pharmacist outpatients' clinic (Part 1). Reviewed

Maruyama T, Sugiura S, Kojima J, Arimasa Y, Satoh Y, Kanaji K, Matsumura T, Ohsumi K, Yamada K and Nabeshima T

J. Appl Therapeut. Res.   Vol. 4   page： 18-24   2003

Cognition impairment in the genetic model of aging, klotho gene mutant mice: a role of oxidative stress. Reviewed

Nagai T, Yamada K, Kim HC, Kim, YS, Noda Y, Imura A, Nabeshima Y and Nabeshima T

FASEB J.   Vol. 17   page： 50-52   2003

Effects of nicotine on memory impairment induced by blockade of muscarinic, nicotinic and dopamine D2 receptors in rats. Reviewed

Hefco V, Yamda K, Hefco A, Hritcu L, Tiron A, Olariu A. and Nabeshima T

Eur. J. Pharmacol.   Vol. 474   page： 227-232   2003

Role of mesotelencephalic dopamine system in learning and memory processes in rats. Reviewed

Hefco V, Yamda K, Hefco A, Hritcu L, Tiron A and Nabeshima T:

Eur. J. Pharmacol.   Vol. 475   page： 55-60   2003

Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrier. Reviewed

Kitagami T, Yamada K, Miura H, Hashimoto R, Nabeshima T and Ohta T

Brain Res.   Vol. 978   page： 104-114   2003

記憶の神経メカニズム‐BDNFを中心とした分子シグナルによる制御‐

水野　誠、山田清文、鍋島俊隆

脳と精神の医学   Vol. 13   page： 389-396   2002

Therapeutic approaches for the treatment of Alzheimer's disease.

Yamada K Kamei Y and Nabeshima T

Drugs Today   Vol. 38   page： 631-637   2002

Amyloid b-peptide induces cholinergic dysfunction and cognitive deficits.

Tran MH, Yamada K and Nabeshima T

Peptides   Vol. 23   page： 1271-1283   2002

Oxidative stress in amyloid b-peptide-induced cholinergic dysfunction and cognitive deficits.

Tran MH, Yamada K and Nabeshima T

Jpn. J. Neuropsychopharmacol.   Vol. 21   page： 125-132   2002

Role for brain-derived neurotrophic factor in learning and memory.

Yamada K, Mizuno M and Nabeshima T

Life Sci.   Vol. 70   page： 735-744   2002

インターネットで学ぶ医療薬学講座 Reviewed

木村和子、松下良、柳川さおり、清水栄、成橋和正、鈴木永雄、山田清文、辻彰、渡辺珠代、石橋弘行

医薬品情報学   Vol. 7   page： 15-19   2002

Absorption of cyclosporin (Neoral) from a microemulsion formulation in a living donor liver transplant recipient. Reviewed

Maeda Y, Kuzuya T, Ota S, Yamada K, Kobayashi T, Hayashi S, Yokoyama I, Nakao A and Nabeshima T

Transplant. P.   Vol. 34   page： 2784-2787   2002

A role of Fos expression in the CA3 region of the hippocampus in spatial memory formation in rats. Reviewed

He J, Yamada K and Nabeshima T

Neuropsychopharmacology   Vol. 26   page： 259-268   2002

Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor e4 subunit. Reviewed

Miyamoto Y, Yamada K, Noda Y, Mori H, Mishina M and Nabeshima T

J. Neurosci.   Vol. 22   page： 2335-2342   2002

Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levels. Reviewed

Nakajima A, Yamada K, Zou L.B., Yan Y., Mizuno M. and Nabeshima T

Free Radic. Biol. Med.   Vol. 32   page： 1324-1332   2002

Memory impairment induced by chronic intracerebroventricular infusion of b-amyloid (140) involves downregulation of protein kinase C. Reviewed

Olariu A, Yamada K, Mamiya T, Hefco V and Nabeshima T

Brain Res.   Vol. 957   page： 278-286   2002

The effect of dietary fiber on morphine-induced constipation in rats. Reviewed

Niwa T, Nakao M, Hoshi S, Yamada K, Inagaki K, Nishida M and Nabeshima T

Biosci. Biotechnol. Biochem.   Vol. 66   page： 1233-1240   2002

Learning and memory in two different reward tasks in a radial arm maze in rats. Reviewed

He J, Yamada K, Nakashima A, H. Kamei and Nabeshima T

Behav. Brain Res.   Vol. 134   page： 139-149   2002

CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. Reviewed

Mizuno M, Yamada K, Maekawa N, Saito K, Seishima M and Nabeshima T

Behav. Brain Res.   Vol. 133   page： 135-141   2002

名古屋大学病院における治験コーディネーターの取り組みとその成果 Reviewed

亀井浩行、加藤経子、安藤幸子、成瀬由香里、市野真弓、白木比奈子、堅田早紀子、加藤純子、宮澤憲治、新出千聡、加藤英里、土井千香子、宇野雅子、葛谷孝文、村岡　勲、伊藤幸代、大原洋子、山田清文、吉田　純、鍋島俊隆、石黒直樹

臨床薬理   Vol. 33   page： 85-91   2002

治験の品質管理における治験コーディネーターの役割 Reviewed

亀井浩行、安藤幸子、加藤経子、成瀬由香里、市野真弓、白木比奈子、堅田早紀子、加藤純子、宮澤憲治、新出千聡、加藤英里、土井千香子、宇野雅子、葛谷孝文、村岡　勲、伊藤幸代、大原洋子、山田清文、石黒直樹、鍋島俊隆

臨床薬理   Vol. 34   page： 19-23   2002

Alzheimer病の薬物療法と創薬

鍋島俊隆、山田清文

医学のあゆみ   Vol. 196   page： 224-227   2001

我が国における抗痴呆薬の開発状況（2000年3月現在）

長谷川雅哉、野田幸裕、前田洋子、亀井浩行、山田清文、鍋島俊隆

臨床精神薬理   Vol. 4   page： 399-410   2001

A selective phosphodiesterase IV inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice. Reviewed

Hamdy MM, Mamiya T, Noda Y, Sayed M, Assi A-A, Gomaa A, Yamada K and Nabeshima T

Behav. Brain Res.   Vol. 118   page： 85-93   2001

Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking NMDA receptor e1 subunit. Reviewed

Miyamato Y, Yamada K, Noda Y, Mori H, Mishina M and Nabeshima T:

J. Neurosci.   Vol. 21   page： 750-757   2001

Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats. Reviewed

He J, Yamada K Zou, L-B and Nabeshima T

J. Neural Transm.   Vol. 108   page： 1435-1443   2001

Memory deficits and increased emotionality induced by b-amyloid(25-25) are correlated with the reduced acetylcholine release and altered phorbol dibutyrate binding in the hippocampus. Reviewed

Olariu A, Tran MH, Yamada K, Mizuno M, Hefco V and Nabeshima T

J. Neural Transm.   Vol. 108   page： 1065-1079   2001

Amyloid b-peptide induces nitric oxide production in rat hippocampus: association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors. Reviewed

Tran MH, Yamada K, Olariu A, Mizuno M, Ren XH and Nabeshima T

FASEB. J.   Vol. 15   page： 1407-1409   2001

Involvement of the cyclic AMP systems in morphine physical dependence in mice: prevention of development of dependence by rolipram, a phosphodiesterase IV inhibitor. Reviewed

Mamiya T, Noda Y, Ren X, Hamdy M, Furukawa S, Kameyama T, Yamada K and Nabeshima T

Br. J. Pharmacol.   Vol. 132   page： 1111-1117   2001

抗痴呆薬の開発の現状と将来

鍋島俊隆、山田清文、野田幸裕、長谷川雅哉、村岡　勲

応用薬理   Vol. 59   page： 1-9   2000

Animal models of Alzheimer's disease and evaluation of anti-dementia drugs.

Yamada K and Nabeshima T

Pharmacol. Therapeut.   Vol. 88   page： 93-113   2000

Neurotrophic factor strategies for the treatment of Alzheimer disease.

Nabeshima T and Yamada K

Alzheimer Dis. Assoc. Disord.   Vol. 14   page： S39-46   2000

抗痴呆薬の進歩

山田清文、鍋島俊隆

Pharm Medica   Vol. 18   page： 73-77   2000

抗痴呆薬開発の戦略：NGFの観点から

水野　誠、山田清文、鍋島俊隆

老年精神医学雑誌   Vol. 11   page： 154-160   2000

β-アミロイド蛋白の脳室内持続注入によるアルツハイマー型痴呆動物モデルの作製と今後の展望

伊東亜紀雄、山田清文、鍋島俊隆

CRJ Letters   Vol. 13   page： 1-8   2000

痴呆症の治療と予防：グルタメイト受容体作用薬

前田洋子、山田清文、鍋島俊隆

Pharm Medica   Vol. 18   page： 81-86   2000

抗痴呆薬の開発動向と21世紀における痴呆の薬物療法

小野寺憲治、山田清文、鍋島俊隆

臨床と薬物治療   Vol. 19   page： 10-18   2000

インビボダイアリシスによる脳内一酸化窒素(NO)代謝物の測定

山田清文、鍋島俊隆

日本薬理学雑誌   Vol. 115   page： 99-104   2000

Suppression of neurocognitive damage in LP-BM5 infected mice with a targeted deletion of the TNFa gene. Reviewed

Iida R, Saito K, Yamada K, Basile AS, Sekikawa K, Takemura M, Fujii H, Wada H, Seishima M and Nabeshima T

FASEB J.   Vol. 14   page： 1023-1031   2000

Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice. Reviewed

Mamiya T, Noda Y, Noda A, Hiramatsu M, Karasawa T, Kameyama T, Furukawa S, Yamada K, and Nabeshima T

Neuropharmacology   Vol. 39   page： 2391-2398   2000

Effects of? s1 receptor agonist SA4503 and neuroactive steroids on performance in a raidal arm maze task in rats. Reviewed

Zou L-B, Yamada K, Sasa M, Nakata Y and Nabeshima T

Neuropharmacology   Vol. 39   page： 1617-1627   2000

Spatiotemporal expression of BDNF in the hippocampus induced by the continuous intracerebroventricular infusion of b-amyloid in rats. Reviewed

Tang P-Y, Yamada K, Kanou Y, Miyazaki T, Xiong X-L, Kambe F, Murata Y, Seo H and Nabeshima T

Mol. Brain Res.   Vol. 80   page： 188-197   2000

*Involvement of BDNF in spatial memory formation and maintenance in a radial arm maze test in rats. Reviewed

Mizuno M, Yamada K, Olariu A, Nawa H and Nabeshima T

J. Neurosci.   Vol. 20   page： 7116-7121   2000

Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-a gene: implications for emotional behavior. Reviewed

Yamada K, Iida R, Miyamoto Y, Saito K, Sekikawa K, Seishima M and Nabeshima T

J. Neuroimmunol.   Vol. 111   page： 131-138   2000

Involvement of nitric oxide in pentylenetetrazol-induced kindling in rats. Reviewed

Han D, Yamada K, Senzaki K, Xiong H, Nawa H and Nabeshima T

J. Neurochem.   Vol. 74   page： 792-798   2000

Protective effects of idebenone and α-tocopherol on β-amyloid-(1-42) induced learning and memory deficits in rats : implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo (共著) Reviewed

Yamada K, Tanaka T, Han D, Senzaki K, Kameyama T and Nabeshima T

Eur. J. Neurosci.   Vol. 11 ( 11 ) page： 83-90   1999

Impairments of nicotinic signal transduction and long-term potentiation in hippocampal slices of β-amyloid-infused rats. Reviewed

Itoh A, Akaike T, Sokabe M, Nitta A, Iida R, Olariu A, Yamada K and Nabeshima T

Eur. J. Pharmacol.   Vol. 382   page： 167-175   1999

Regulation of nerve growth factor release by nitric oxide in cortical glial cells. Reviewed

Xiong H, Yamada K, Jourdi H, Kawamura M, Takei N, Han D, Nabeshima T and Nawa H

Mol. Pharmacol.   Vol. 56   page： 339-347   1999

Long-term deprivation of estrogens by ovariectomy potentiates β-amyloid-indued working memory deficits in rats. Reviewed

Yamada K, Tanaka T, Zou L-B, Senzaki K, Yano K, Osada T, Olariu A, Ren X, Kameyama T and Nabeshima T

Br. J. Pharmacol.   Vol. 128   page： 419-427   1999

Mutual regulation between the intercellular messengers nitric oxide and brain-derived neurotrophic factor in rodent neocortical neurons. Reviewed

Xiong H, Yamada K, Han D, Nabeshima T, Enikolopov G, Carnahan J and Nawa H

Eur. J. Neurosci.   Vol. 11   page： 1567-1576   1999

Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, amurine model of AIDS. Reviewed

Iida R, Yamada K, Mamiya T, Saito K, Seishima M and Nabeshima T

J. Neuroimmunol.   Vol. 95   page： 65-72   1999

我が国における抗痴呆薬の開発状況(1999年3月現在)

長谷川雅哉、野田幸裕、前田洋子、山田清文、鍋島俊隆

日本薬理学雑誌   Vol. 114   page： 327-336   1999

Perspectives of pharmacotherapy in Alzheimer's disease. Reviewed

Yamada K, Ren X and Nabeshima T

Jpn. J. Pharmacol.   Vol. 80   page： 9-14   1999

治験に係わる診療の特定療養費制度の問題点

葛谷孝文、加藤勝義、山田清文、鍋島俊隆

日本病院薬剤師会雑誌   Vol. 35   page： 1507-1510   1999

ラット脳室内へのβ-アミロイド蛋白の持続注入により誘発される学習記憶障害の発現機序

山田清文、鍋島俊隆

医科学応用研究財団研究報告   Vol. 18   page： 178-182   1999

学習・記憶とレセプター

前田洋子、山田清文、鍋島俊隆

Pharm D   Vol. 2   page： 31-35   1999

平成10年度厚生科学研究費補助金医薬安全総合研究事業「医薬品の適正使用における病院薬剤師の役割」―外国人研究者招聘事業（東海・関西地区）―

鍋島俊隆、松葉和久、岡田　啓、全田　浩、奥村勝彦、横山昭由、菅家浦子、山田清文

日本病院薬剤師会雑誌   Vol. 35   page： 1287-1291   1999

Brain dysfunction associated with an induction of nitric oxide synthase following an intracerebral injection of lipopolysaccharide in rats. Reviewed

Yamada K, Komori Y, Tanaka T, Senzaki K, Nikai T, Sugihara H, Kameyama T and Nabeshima T

Neuroscience   Vol. 88   page： 281-294   1999

Improvement of nefiracetam of β-amyloid-(1-42)-induced learning and memory impairment in rats. Reviewed

Yamada K, Tanaka T, Mamiya T, Shiotani T, Kameyama T and Nabeshima T

Br. J. Pharmacol.   Vol. 126   page： 235-244   1999

Two phases of behavioral plasticity in rats following unilateral excitotoxic lesion of the hippocampus. Reviewed

Zou L-B, Yamada K, Sasa M and Nabeshima T

Neuroscience   Vol. 92   page： 819-826   1999

The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (s) receptor ligands involves both s1 and s2 sites. Reviewed

Maurice T, Phan V, Noda Y, Yamada K, Privat A and Nabeshima T

Br. J. Pharmacol.   Vol. 127   page： 335-342   1999

Propentofylline improves learning and memory deficits induced in rats by β-amyloid protein-(1-40). Reviewed

Yamada K, Tanaka T, Senzaki K, Kameyama T and Nabeshima T

Eur. J. Pharmacol.   Vol. 349   page： 15-22   1998

Changes in NMDA receptor/nitric oxide signaling pathway in the brain with aging.

Yamada K and Nabeshima T

Microsc. Res. Techniq.   Vol. 43   page： 68-74   1998

Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged Rats. Reviewed

Miyagawa H, Hasegawa M, Fukuta T, Amano M, Yamada K and Nabeshima T

Behav. Brain Res.   Vol. 91   page： 73-81   1998

σ Receptor ligand(+)-SKF10047 and SA4503 improve dizocilpine-induced spatial memory deficits in rats Reviewed

Zou L-B, Yamada K and Nabeshima T

Eur. J. Pharmacol.   Vol. 355   page： 1-10   1998

NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by β-amyloid protein in rats. Reviewed

Tanaka T, Yamada K, Senzaki K, Narimatsu M, Nishimura K, Kameyama T and Nabeshima T

Eur. J. Pharmacol.   Vol. 352   page： 135-142   1998

学習記憶過程におけるガス状情報伝達物質 一酸化窒素(NO)の役割の解明-最終報告-

    1998

学習記憶における一酸化窒素の役割

山田清文、鍋島俊隆

医学のあゆみ   Vol. 183   page： 674-675   1998

不老長寿の薬

山田清文、鍋島俊隆

  Vol. 36   page： 71-74   1998

学習記憶過程における一酸化窒素の役割

山田清文

日本薬理学雑誌   Vol. 111   page： 87-96   1998

Nitric oxide and cyclic GMP signaling pathway in learning and memory processes

Yamada K and Nabeshima T

Curr Top Pharmacol   Vol. 4   page： 77-86   1998

Modulation of nitric oxide production in vivo in the brain.

Yamada K and Nabeshima T

Meth. Find. Exp. Clin. Pharmacol.   Vol. 20   page： 601-605   1998

Nitric oxide synthase inhibitors impair reference memory formation in a radial arm maze task in rats. Reviewed

Zou L-B, Yamada K, Tanaka T, Kameyama T and Nabeshima T

Neuropharmacology   Vol. 37   page： 323-330   1998

連合学習と長期増強

山田清文、鍋島俊隆

日本薬理学雑誌   Vol. 111   page： 190   1998

株化神経系細胞PC12におけるインターロイキン-6の細胞保護作用

山田清文、梅垣宏行、井口昭久、鍋島俊隆

臨床薬理の進歩   Vol. 18   page： 87-91   1997

Simultaneous measurement of nitrite and nitrate levels as indices of nitric oxide release in the cerebellum of conscious rats. Reviewed

Yamada K and Nabeshima T

J. Neurochem.   Vol. 68   page： 1234-1243   1997

学習記憶過程におけるガス状情報伝達物質 一酸化窒素(NO)の役割の解明-中間報告-

  Vol. 24   page： 90   1997

Orally active NGF synthesis stimulators: Potential therapeutic agents in Alzheimer's disease.

Yamada K, Nitta A, Hasegawa T, Fuji K, Hiramatsu M, Kameyama T, Furukawa Y, Hayashi K and Nabeshima T

Behav. Brain Res.   Vol. 83   page： 117-122   1997

Role of nitric oxide in the effect of aging on spatial memory in rats. Reviewed

Noda Y, Yamada K and Nabeshima T

Behav. Brain. Res.   Vol. 83   page： 153-158   1997

No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging. Reviewed

Yamada K, Nishiwaki K, Hattori K, Senzaki K, Nagata M, Komatsu T, Simada Y and Nabeshima T

J. Neural Transm.   Vol. 104   page： 825-831   1997

学習記憶過程における一酸化窒素の役割に関する研究

  Vol. 650   page： 8   1997

Two Pathways of nitric oxide production through glutamate receptors in the rat cerebellum in vivo. Reviewed

Yamada K and Nabeshima T

Neurosci. Res.   Vol. 28   page： 93-102   1997

Changes in extracellular nitrite and nitrate levels after inhibition of glial metabolism with fluorocitrate. Reviewed

Yamada K, Senzaki K, Komori Y, Nikai T, Sugihara H and Nabeshima T

Brain Res.   Vol. 762   page： 72-78   1997

Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells. Reviewed

Yamada K, Umegaki H, Maezawa I, Iguchi A, Kameyama T and Nabeshima T

Brain Res. Bull.   Vol. 43   page： 573-577   1997

Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore. Reviewed

Umegai H, Yamada K, Naito M, Kameyama T, Iguchi A and Nabeshima T

Biochem. Pharmacol.   Vol. 52   page： 911-916   1996

Nefiracetam (DM-9384): a novel antiamnesic drug.

Yamada K and Nabeshima T

CNS Drug Rev.   Vol. 2   page： 322-342   1996

The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice. Reviewed

Yamada K, Noda Y, Hasegawa T, Komori Y, Nikai T, Sugihara H and Nabeshima T

J. Pharmacol. Exp. Ther.   Vol. 276   page： 460-466   1996

NGFの産生を促進する薬剤について

FAX DIニュース   Vol. 119   page： 1   1996

Role of dopaminergic neuronal system in dizocilpine-induced acethylcholine release in the rat brain. Reviewed

Hasegawa M, Yamada K, Hasegawa T and Nabeshima T

J. Neural Transm.   Vol. 103   page： 651-660   1996

Effects of dietary vegetable oils on behavior and drug responses in mice. Reviewed

Kameyama T, Ohhara T, Nakashima Y, Naito Y,Huang M, Watanabe S, Kobayashi T, Okuyama H, Yamada K and Nabeshima T

Biol. Pharm. Bull.   Vol. 19   page： 400-404   1996

シグマ受容体リガンドの中枢薬理作用、-抗不安作用、学習記憶障害改善作用および脳保護作用を中心に-

天野　学、山田清文、松野　聖、鍋島俊隆

日本神経精神 薬理学雑誌   Vol. 16   page： 73-84   1996

Role of nitric oxide and cyclic GMP in the dizocilpine-induced impairment of spontaneous alternation behavior in mice. Reviewed

Yamada K, Hiramatsu M, Noda Y, Mamiya T, Murai M, Kameyama T, Komori Y, Nikai T, Sugihara H and Nabeshima T

Neuroscience   Vol. 74   page： 365-374   1996

Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats. Reviewed

Yamada K, Noda Y, Komori Y, Sugihara H, Hasegawa T and Nabeshima T

Neurosci. Res.   Vol. 24   page： 393-402   1996

Role of nitric oxide in the development of tolerance and sensitization to behavioral effects of phencyclidine in mice. Reviewed

Noda Y, Yamada K, Komori Y, Sugihara H, Furukawa H and Nabeshima T

Br. J. Pharmacol.   Vol. 117   page： 1579-1585   1996

Effects of the subacute administration of nefiracetam on abnormal behavior in aged rats. Reviewed

Hasegawa M, Nakayama S, Kinoshita H, Amano M, Yamada K, Hasegawa T, and Nabeshima T

Behav. Brain. Res.   Vol. 78   page： 93-100   1996

Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40)protein. Reviewed

Yamada K, Nitta A, Saito T, Hu J and Nabeshima T

Neurosci. Lett.   Vol. 201   page： 155-158   1995

Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. Reviewed

Yamada K, Kono K, Umegaki H, Yamada K, Iguchi A, Fukatsu T, Nakashima N, Nishiwaki H, Shimada Y, Sugita Y, Yamamoto T, Hasegawa T and Nabeshima T

Neurosci. Lett.   Vol. 186   page： 219-221   1995

Neuronal mechanism of the inhibitory effects of calcitonin on N-methyl-D-aspartate-induced aversive behavior. Reviewed

Maeda Y, Yamada K, Hasegawa T and Nabeshima T

Eur. J. Pharmacol.   Vol. 275   page： 163-170   1995

Stress-induced behavioral responses and multiple opioid systems in the brain.

Yamada K and Nabeshima T

Behav. Brain Res.   Vol. 67   page： 133-145   1995

Possible involvement of nitric oxide in quinolinic acid-induced convulsion in mice. Reviewed

Nakamura T, Yamada K, Hasegawa T and Nabeshima T

Pharmacol. Biochem. Behav.   Vol. 51   page： 309-312   1995

Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine : a new model of schizophrenia. Reviewed

Noda Y, Yamada K, Furukawa H and Nabeshima T

Br. J. Pharmacol.   Vol. 116   page： 2531-2537   1995

強制水泳時の無動状態に対するphencyclidineによる影響

野田幸裕、山田清文、中山忍、長谷川高明、古川宏、鍋島俊隆

  Vol. 21   page： 131-134   1995

サイトカインの神経栄養因子作用と神経疾患

山田清文、鍋島俊隆

  Vol. 10   page： 605-608   1995

Phencyclidine increases the extracellular acetylcholine level in the parietal cortex partly through sigma receptors. Reviewed

Ohzeki M, Hasegawa M, Katoh T, Yamada K, Hasegawa T, Furukawa H and Nabeshima T

Res. Commun. Alcohol Sub. Abuse   Vol. 16   page： 97-103   1995

Involvement of nitric oxide in phencyclidine-induced hyperlocomotion in mice. Reviewed

Noda Y, Yamada K, Furukawa H and Nabeshima T

Eur. J. Pharmacol.   Vol. 286   page： 291-297   1995

The attenuation of suppression of motility by triazolam in the conditioned fear stress task in exacerbated by ethanol in mice. Reviewed

Kitaichi K, Minami Y, Amano M, Yamada K, Hasegawa T and Nabeshima T

Life Sci.   Vol. 57   page： 743-753   1995

Role of nitric oxide in learning and memory and in monoamine metabolism in the brain of rats. Reviewed

Yamada K, Noda Y, Nakayama S, Komori Y, Sugihara H, Hasegawa T and Nabeshima T

Br. J. Pharmacol.   Vol. 115   page： 852-858   1995

NOによる脳機能の調節

山田清文、鍋島俊隆

  Vol. 32   page： 893-894   1995

Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task. Reviewed

Nabeshima T, Nakayama S, Ichihara K, Yamada K, Shiotani T and Hasegawa T

Eur. J. Pharmacol.   Vol. 255   page： 57-65   1994

Possible involvement of the activation of voltage-sensitive calcium channels in the ameliorating effects of nefiracetam on scopolamine-induced impairment of performance in a passive avoidance task. Reviewed

Yamada K, Nakayama S, Shiotani T, Hasegawa T and Nabeshima T

J. Pharmacol. Exp. Ther.   Vol. 270   page： 881-892   1994

ω-Conotoxin GVIA inhibits methylphenidate-induced but not methamphetamine-induced behavior. Reviewed

Yamada K, Teraoka T, Seiji M, Hasegawa T and Nabeshima T

Neurosci. Lett.   Vol. 165   page： 191-194   1994

Effects of Kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography. (2) Changes in GABA_A and benzodiazepine receptor binding. Reviewed

Yamada K, Hayashi T, Hasegawa T, Ishihara S, Kameyama T, Morimasa T, Kaneyuki T, Shohmori T and Nabeshima T

Jpn. J. Pharmacol.   Vol. 66   page： 53-58   1994

Relationship between anti-aversive effects of salmon calcitonin and plasma levels of ACTH, beta-endorphin and prostaglandin E₂ in mice. Reviewed

Maeda Y, Yamada K, Hasegawa T, Kawamata Y, Uchida K, Iyo M, Fukui S and Nabeshima T

Res. Commun. Chem. Pathol. Pharmacol.   Vol. 83   page： 15-24   1994

Effects of resperidone on phencyclidine-induced behavior : comparison with haloperidol and ritanserin. Reviewed

Kitaichi K, Yamada K, Hasegawa T, Furukawa H and Nabeshima T

Jpn. J. Pharmacol.   Vol. 66   page： 181-189   1994

視覚テスト

山田清文、鍋島俊隆

生体の科学   Vol. 45   page： 484-485   1994

聴覚テスト

山田清文、鍋島俊隆

生体の科学   Vol. 45   page： 482-483   1994

Resperidone prevents the development of super-sensitivity, but not tolerance, to phencyclidine in rats treated with subacute phencyclidine. Reviewed

Kitaichi K, Yamada K, Yoneda Y, Ogita K, Hasegawa T, Furukawa H and Nabeshima T

Life Sci.   Vol. 56   page： 531-543   1994

Changes in muscarinic cholinergic, PCP, GABA_A, D₁ and 5-HT_2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats. Reviewed

Nabehsima T, Yamada K, Hayashi T, Hasegawa T, Ishihara S, Kameyama T, Morimasa T, Kaneyuk T and Shohmori T

Life Sci.   Vol. 55   page： 1585-1593   1994

Effects of Kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography : Changes in dopamine D₁ and serotonin-5-HT_2A receptor binding. Reviewed

Ishihara S, Yamada K, Hayashi T, Hasegawa T, Kameyama T, Morimasa T, Kaneyuki T, Shohmori T and Nabeshima T

Biol. Pharm. Bull.   Vol. 17   page： 1132-1134   1994

Effects of Kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by vitro autoradiography (1) Changes in the [3H]QNB binding. Reviewed

Hayashi T, Yamada K, Hasegawa T, Ishihara S,Kameyama T, Morimasa T, Kaneyuki T, Shohmori T and Nabeshima T

Jpn. J. Pharmacol.   Vol. 64   page： 303-306   1994

Oral administration of idevenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats. Reviewed

Nitta A, Murakami Y, Furukawa Y, Kawatsura W, Hayashi K, Yamada K, Hasegawa T and Nabeshima T

Naunyn-Schemiedeberg's Arch Pharmacol.   Vol. 349   page： 401-407   1994

ω-Conotoxin GVIA protects against ischemia-induced neuronal death in the Mongolian gerbil but not quinolinic acid-induced neurotoxicity in the rat. Reviewed

Yamada K, Teraoka T, Seiji M, Hasegawa T and Nabeshima T

Neuropharmacology   Vol. 33   page： 251-254   1994

Inhibitory effects of salmon salcitonin on the tail-biting and scratching behavior. Reviewed

Maeda Y, Yamada K, Hasegawa T, Iyo M, Fukui S and Nabeshima T

J. Neural Transm.   Vol. 96   page： 125-133   1994

The inhibitory effects of salmon calcitonin on intrathecally-injected N-methyl-D-aspartate-induced aversive behavior in mice. Reviewed

Nabeshima T, Maeda Y, Yamada K, Nakamura T and Hasegawa T

Res. Commun. Chem. Pathol. Pharmacol.   Vol. 82   page： 175-184   1993

Neuropharmacological characterization of voltage-sensitive calcium channels : Possible existence of neomycin-sensitive, ω-conotoxin GVIA-and dihydropyridines-resistant calcium channels in the rat brain. Reviewed

Yamada K, Teraoka T, Seiji M, Hasegawa T and Nabeshima T:

Jpn J. Pharmacol.   Vol. 63   page： 423-432   1993

Neuroprotective and antiamnesic effects of NMDA antagonists.

Yamada K and Nabeshima T

Drug News Perspectives   Vol. 4   page： 524-529   1991

Effects of calmodulin antagonists on sodium-dependent high-affinity choline uptake. Reviewed

Yamada K, Saltarelli MD and Coyle JT

Brain. Res.   Vol. 542   page： 132-134   1991

Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle. Reviewed

Yamada K, Nabeshima T and Kameyama T

J. Pharmacobio-Dyn.   Vol. 14   page： 351-355   1991

Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody. Reviewed

Nabeshima T, Ogawa S, Yamada K, Ishimaru H, Fuji K, Kameyama T, Fukuta T, Takeuchi R and Hayashi K

Res. Commun. Chem. Pathol. Pharmacol.   Vol. 74   page： 141-152   1991

[3H]Hemicholinium-3 binding in rats with status epilepticus induced by lithium and pilocarpine. Reviewed

Yamada K, Saltarelli MD and Coyle JT

Eur. J. Pharmacol.   Vol. 195   page： 395-397   1991

Phospholipase A2 and [3H]hemicholinium-3 binding sites in rat brain : a potential second messenger role for fatty acids in the regulation of high-affinity choline uptake. Reviewed

Saltarelli MD, Yamada K and Coyle JT

J. Neurosci.   Vol. 10   page： 62-72   1990

Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats. Reviewed

Yamada K, Fuji K, Nabeshima T and Kameyama T

Neurosci. Lett.   Vol. 118   page： 128-131   1990

Specificity of the activation of [3H]hemicholinium-3 binding by phospholipase A₂. Reviewed

Yamada K, Saltarelli MD and Coyle JT

J. Pharmacol. Exp. Ther.   Vol. 249   page： 836-842   1989

7-[3-(4-[2,3-dimethylphenyl]piperazinyl)propoxy]-2(1H)-qinolinone(OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D₂ receptor agonist. Reviewed

Yasuda Y, Kikuchi K, Suzuki S, Tsutsui M, Yamada K and Hiyama T

Life Sci.   Vol. 42   page： 1941-1954   1988

Solubilization and characterization of a [3H]hemicholinium-3 binding site in rat brain. Reviewed

Yamada K, Saltarelli MD and Coyle JT

J. Neurochem.   Vol. 50   page： 1759-1764   1988

Involvement of phospholipase A₂ in the regulation of [3H]hemicholimium-3 binding. Reviewed

Yamada K, Saltarelli MD and Coyle JT

Biochem. Pharmacol.   Vol. 37   page： 4367-4373   1988

電気ショックによる行動変化と脳内オピオイド受容体

鍋島俊隆、松野　聖、山田清文、亀山　勉

  Vol. 11   page： 132-146   1985

Differences of alteration in opioid systems induced by conditioned suppression and electric footshock in mice. Reviewed

Kameyama T, Nabeshima T and Yamada K

Pharmacol. Biochem. Behav.   Vol. 22   page： 249-254   1985

Effects of antidepressant drugs on a quickly-learned conditioned suppression in mice. Reviewed

Kameyama T, Nagasaka M and Yamada K

Neuropharmacology   Vol. 24   page： 285-290   1985

条件抑制におけるdopamineおよびopioid神経系の役割

生物学的精神医学 最近の進歩   Vol. 1   page： 186-195   1985

Sex-dependent differences in the pharmacological actions and pharmacokinetics of phencyclidine in rats Reviewed

Nabeshima T, Yamaguchi K, Yamada K, Hiramatsu M, Furukawa H and Kameyama T

Eur. J. Pharmacol.   Vol. 97   page： 217-227   1984

Effects of opiate agonists on the conditioned suppression in motility of mice. Reviewed

Nabeshima T, Yamada K and Kameyama T

Neurosci. Lett.   Vol. 39   page： 301-306   1983

Effects of lesions in the striatum, nucleus accumbens and medial raphe on phencyclidine-induced stereotyped behaviors and hyperactivity in rats. Reviewed

Nabeshima T, Yamada K, Yamaguchi K, Hiramatsu M, Furukawa H and Kameyama T

Eur. J. Pharmacol.   Vol. 91   page： 455-462   1983

Contribution of different opioid systems on foot-shock-induced analgesia and motor suppression. Reviewed

Nabeshima T, Yamada K and Kameyama T

Eur. J. Pharmacol.   Vol. 92   page： 199-205   1983

Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum. Reviewed

Nabeshima T, Yamaguchi K, Yamada K, Hiramatsu M, Furukawa H and Kameyama T

Eur. J. Pharmacol.   Vol. 93   page： 229-234   1983

スタンダード薬学シリーズ９、薬学と社会 第２版（日本薬学会編）・第8章　地域薬局の役割（SBO30-32）

山田清文（ Role： Joint author）

東京化学同人  2008.3 

Memory improvement, In: Encyclopedia of Neuroscience (C. Binder MD, Hirokawa N, Windhorst U, Hirsch MC, eds)

Yamada K and Nabeshima T（ Role： Joint author）

Springer-Verlag Berlin and Heidelberg  2007 

南山堂医学大辞典第19版・抗不安薬、催眠鎮静薬

山田清文（ Role： Joint author）

南山堂  2006 

ストレスの事典（河野友信、石川俊男編）・基礎編第3章6節ストレスと行動

山田清文、鍋島俊隆（ Role： Joint author）

浅倉書店  2005 

薬学生・実習指導者のための実務実習ガイドブック

鍋島俊隆、榛葉哲男監修、山田清文、他２３名編集（ Role： Joint author）

南山堂  2005 

クリニカルファーマシーのための疾病解析 第7版(福地　坦監訳）・第7章　生物工学

山田清文、鍋島俊隆（ Role： Joint author）

医薬ジャーナル社  2005 

Molecular mechanism of amyloid-β-induced impairment of neurotransmission and memory in relation to oxidative stress, In: Recent Progress in Alzheimer’s and Parkinson’s Disease (Hanin I, Cacabelos R and Fisher A, eds)

Yamada K, Kim HC and Nabeshima T（ Role： Joint author）

Taylor & Francis, London  2005 

スタンダード薬学シリーズ９、薬学と社会（日本薬学会編）・第8章　地域薬局の役割（SBO30-32）

山田清文（ Role： Joint author）

東京化学同人  2004.11 

Nitric oxide in learning and memory, In: From Messengers to Molecules: Memories are Made of These (Riedel, G., Platt, B., eds)

Yamada K and Nabeshima（ Role： Joint author）

Landes Bioscience, Georgetown, Texas  2004 

Development of anti-dementia drugs for Alzheimer’s disease: present and future, In: Mapping the Progress of Alzheimer’s and Parkinson’s Disease (Mizuno Y, Fisher A, Hanin I, eds)

Nabeshima T and Yamada, K（ Role： Joint author）

Kluwer Academic/Plenum Publishers, New York  2002 

Role of inducible nitric oxide synthase in β-amyloid-induced brain dysfunction in rats, In: Mapping the Progress of Alzheimer’s and Parkinson’s Disease (Mizuno Y, Fisher A, Hanin I, eds)

Yamada K, Tran MH, Kim HC and Nabeshima T（ Role： Joint author）

Kluwer Academic/Plenum Publishers, New York  2002 

非臨床試験マニュアル（野村護、堀井郁夫、吉田武美編）・第４ 節モデル動物の利用と評価—脳—

石川和宏、山田清文、鍋島俊隆（ Role： Joint author）

エル・アイ・シー  2001 

New therapeutic approaches to Alzheimer's disease, In Neuroscientific Basis of Dementia (C. Tanaka, P.L. McGeer and Y. Ihara, eds)

Nabeshima T and Yamada K（ Role： Joint author）

Birkhäuser Verlag, Basel  2001 

臨床精神医学講座「アルツハイマー病」（松下正明編）・新しい治療薬の開発

鍋島俊隆、山田清文（ Role： Joint author）

中山書店  2000.6 

咬合状態に起因する他臓器の異常（厚生科学研究「口腔保健と全身的な健康状態の関係について」運営協議会（座長：小林修平）編）・歯牙喪失による脳機能の変化―学習記憶およびアセチルコリン遊離の障害―

山田清文、長谷川雅哉、加藤武司、上田　実、鍋島俊隆（ Role： Joint author）

財団法人口腔保健協会  2000 

薬物治療学　第２版（南　勝、木皿憲佐編）・薬物療法での注意

山田清文、鍋島俊隆（ Role： Joint author）

南山堂  2000 

クリニカルファーマシーのための疾病解析 第6版(福地　坦監訳）・第75章　免疫抑制患者における感染症

山田清文、鍋島俊隆（ Role： Joint author）

医薬ジャーナル社  1999 

Nitric oxide production in vivo in the brain following a direct intrahippocampal injection of lipopolysaccharide in rats, In: The Biology of Nitric Oxide. Part 6. (Moncada S, Toda N, Maeda H and Higgs EA eds)

（ Role： Joint author）

Portland Press, U. K.  1998 

Nitric oxide production caused by activation of non-N-methyl-D-aspartate and metabotropic glutamate receptors may be independent on nitric oxide synthase in the rat cerebellum in vivo, In: The Biology of Nitric Oxide. Part 6. (Moncada S, Toda N, Maeda H and Higgs EA eds)

（ Role： Joint author）

Portland Press, U. K.  1998 

神経伝達物質 update ―基礎から臨床まで 第３版（中村重信編）・拮抗物質

山田清文、鍋島俊隆（ Role： Joint author）

中外医学社  1998 

レセプター分子薬理学的アプローチ　初版（日高弘義、谷口隆之、宇井理編）・中枢レセプターと行動

山田清文、鍋島俊隆（ Role： Joint author）

講談社  1997 

神経行動薬理学研究の最前線―抗痴呆薬研究の最近の進歩―（小野寺憲治編）・学習記憶と伝達物質研究の進歩と最前線

山田清文、鍋島俊隆（ Role： Joint author）

Prous Science，Spain  1997 

薬物治療学　初版（南　博、木皿憲佐著者代表）・薬物療法での注意

山田清文、鍋島俊隆（ Role： Joint author）

南山堂  1997 

医療薬学　新薬論　初版（金久保好男編）・向精神薬

篠田正彦、山田清文、鍋島俊隆（ Role： Joint author）

広川書店  1995 

Memory impairment in rats induced by an active fragment of nerve growth factor antibody. In: Basic, clinical and therapeutic aspects of Alzheimer's and Parkinson's disease. Vol 1. (Nagatsu T et al., eds)

（ Role： Joint author）

Plenum Press, NY  1990 

生物学的精神医学　最近の進歩　初版（難波益之編）・条件抑制におけるdopamine およびopioid 神経系の役割

鍋島俊隆、亀井浩行、加藤　晃、長坂光昭、山田清文、亀山　勉（ Role： Joint author）

ヘスコインターナショナル  1985 

Sex differences in the pharmacological actions of phencyclidine in rats. In: Phencylcidine and related arylcyclohexylamines. Present and future applications. (J.M. Kamenka, E.F. Domino and P. Geneste, eds)

（ Role： Joint author）

NPP Books, Ann Arbor  1983