研究者詳細 - 佐藤　義朗

論文 - 佐藤　義朗

分割表示 125 件中 41 - 60 件目／全件表示 >>

Impact of the Coronavirus Disease 2019 Pandemic on the Clinical Features of Pediatric Respiratory Syncytial Virus Infection in Japan. 査読有り

Ozeki S, Kawada JI, Yamashita D, Yasufuku C, Akano T, Kato M, Suzuki K, Tano C, Matsumoto K, Mizutani SH, Mori A, Nishio N, Kidokoro H, Yasui Y, Takahashi Y, Sato Y, Nagoya Collaborative Clinical Research Team

Open forum infectious diseases 9 巻 ( 11 ) 頁： ofac562 2022年11月

Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan. 査読有り国際誌

Ushida T, Nakamura N, Nakatochi M, Kobayashi Y, Sato Y, Iitani Y, Imai K, Nakano-Kobayashi T, Hayakawa M, Kajiyama H, Kotani T, Neonatal Research Network of Japan

Pregnancy hypertension 29 巻頁： 54 - 60 2022年8月

Safety and tolerability of a multilineage-differentiating stress-enduring cell-based product in neonatal hypoxic-ischaemic encephalopathy with therapeutic hypothermia (SHIELD trial): a clinical trial protocol open-label, non-randomised, dose-escalation trial. 査読有り国際誌

Matsuyama N, Shimizu S, Ueda K, Suzuki T, Suzuki S, Miura R, Katayama A, Ando M, Mizuno M, Hirakawa A, Hayakawa M, Sato Y

BMJ open 12 巻 ( 4 ) 頁： e057073 2022年4月

Relationship between Neonatal MRI Findings and Emotional/Behavioral Evaluation in Early Childhood for Extremely Low-Birth-Weight Infants. 査読有り国際誌

Taniguchi A, Hayakawa M, Kataoka E, Fujishiro N, Sato Y

Journal of clinical medicine 11 巻 ( 3 ) 2022年1月

Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study. 査読有り国際誌

Katsuki S, Ushida T, Kidokoro H, Nakamura N, Iitani Y, Fuma K, Imai K, Nakano-Kobayashi T, Sato Y, Hayakawa M, Natsume J, Kajiyama H, Kotani T

Early human development 163 巻頁： 105479 - 105479 2021年12月

Trajectory of the incidence of brushes on preterm electroencephalogram and its association with neurodevelopment in extremely low birth weight infants. 査読有り国際誌

Maeda T, Kidokoro H, Tachibana T, Shiraki A, Yamamoto H, Nakata T, Fukasawa T, Kubota T, Sato Y, Kato T, Natsume J, Okumura A, Hayakawa M

Brain & development 43 巻 ( 10 ) 頁： 979 - 987 2021年11月

Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study. 査読有り国際誌

Ushida T, Kidokoro H, Nakamura N, Katsuki S, Imai K, Nakano-Kobayashi T, Moriyama Y, Sato Y, Hayakawa M, Natsume J, Kajiyama H, Kotani T

Pregnancy hypertension 25 巻頁： 143 - 149 2021年8月

Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy. 査読有り国際誌

Suzuki T, Sato Y, Kushida Y, Tsuji M, Wakao S, Ueda K, Imai K, Iitani Y, Shimizu S, Hida H, Temma T, Saito S, Iida H, Mizuno M, Takahashi Y, Dezawa M, Borlongan CV, Hayakawa M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 41 巻 ( 7 ) 頁： 1707 - 1720 2021年7月

Diverse actions of cord blood cell therapy for hypoxic-ischemic encephalopathy. 招待有り査読有り国際誌

Sato Y, Tsuji M

Pediatrics international : official journal of the Japan Pediatric Society 63 巻 ( 5 ) 頁： 497 - 503 2021年5月

Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection. 査読有り

Takemoto K, Oshiro M, Sato Y, Yamamoto H, Ito M, Hayashi S, Kato E, Kato Y, Hayakawa M

Nagoya journal of medical science 83 巻 ( 2 ) 頁： 311 - 319 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

Premature infants are at risk for developing symptomatic postnatal cytomegalovirus (CMV) disease, including sepsis-like syndrome. We performed a retrospective case-control study including infants born before 32 weeks of gestation and diagnosed with symptomatic postnatal CMV infection during the neonatal period. Neurodevelopmental outcome was evaluated using the Kyoto Scale of Psychological Development 2001 at 18 months of corrected age and at 3 years of age. Twenty-four infants were diagnosed with postnatal CMV infection; of them, 14 had sepsis-like symptoms and 10 had laboratory test abnormalities only. Home oxygen therapy was used significantly higher in the CMV-positive group compared with the control group at hospital discharge (52% vs 21%, P=0.032). The incidence of neurodevelopmental impairment was not significantly different between the two groups at 18 months of corrected age (29% vs 17%, P=0.48) and at 3 years of age (43% vs 29%, P=0.34). Postnatal CMV infection did not have a significant influence on neurodevelopmental outcomes of symptomatic preterm infants, although those in the CMV-positive group appeared worse. Larger studies with long-term follow-up are needed for a better understanding of continued neurodevelopmental outcomes in preterm infants with postnatal CMV infection.

DOI： 10.18999/nagjms.83.2.311

PubMed

ドップラーセンサを用いた新生児の心拍測定におけるテンプレートマッチング呼吸残差法の検討査読有り

上林眞司, 森智也, 佐藤義朗

電子情報通信学会論文誌B 通信 J104-B 巻 ( 3 ) 頁： 369 - 378 2021年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：電子情報通信学会

従来，ドップラーセンサを使い，電波により遠隔で心拍を測定する方法の研究が数多く報告されているが，呼吸・体動の影響の除去が課題であった．心拍による胸壁の振幅は，呼吸による振幅の1/10程度であり，更に心拍間隔，呼吸間隔は共に，1周期ごとにわずかに変動するため，呼吸と心拍が混在する信号波形から心拍のみを抽出し精度よく測定することは容易ではない．本研究では，体動の少ない保育器内の新生児をターゲットとし，ドップラーセンサ出力波形から呼吸のテンプレート波形を自動的に生成し，テンプレートマッチング法により1周期ごとに同期して呼吸波形を除去して心拍を測定する方法を提案する．本手法を新生児モデル実験及び成人実験に適用した結果，測定時間10秒の場合，心拍間隔の平均値の測定誤差3%程度の遠隔心拍測定が実現できることを確認した．

DOI： 10.14923/transcomj.2020jbp3039

CiNii Research

Brain damage caused by neonatal hypoxia-ischemia and the effects of hypothermia in severe combined immunodeficient (SCID) mice. 査読有り国際誌

Ogawa Y, Tanaka E, Sato Y, Tsuji M

Experimental neurology 337 巻頁： 113577 - 113577 2021年3月

Non-invasive biosignals detection for continuous monitoring of a neonate using quartz crystal resonator 査読有り

Shiro Watanabe, Yuichi Murozaki, Hirotaka Sugiura, Yoshiaki Sato, Kazuya Honbe, Fumihito Arai

Sensors and Actuators A: Physical 317 巻頁： 112475 - 112475 2021年1月

Muse細胞を用いた新生児低酸素性虚血性脳症の新規治療法開発～動物実験から探索的臨床試験（医師主導治験）まで～招待有り査読有り

佐藤義朗

日本周産期・新生児医学会雑誌 56 巻 ( 4 ) 頁： 586 - 589 2021年

担当区分：筆頭著者,　最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本周産期・新生児医学会

はじめに　新生児死亡率は年々減少しているが，脳性麻痺の発症は出生1,000人に対し，1.5から2.5の間であり一向に減少の兆しがない．脳性麻痺は生涯続き，1人当たりの経済的費用は約1億円と非常に高額である．患者本人はもちろん，支える家族にとっても大きな負担となる．そのため脳性麻痺を未然に防ぐことが極めて重要である．　周産期低酸素性虚血性脳症（HIE）は，脳性麻痺の主たる原因である．発症頻度は出生1,000人に対し1.3から1.7であるが，確立した治療は低体温療法のみである．その低体温療法も18カ月後の死亡，もしくは，重度の神経学的後遺症を減少させる治療必要数（NNT：number needed to treat）は9と効果は限定的であり，新たな治療法が望まれる．そこで，我々は幹細胞療法に着目し，研究を進めてきた．

DOI： 10.34456/jjspnm.56.4_586

CiNii Research

Metabolomic analysis and mass spectrometry imaging after neonatal stroke and cell therapies in mouse brains. 査読有り国際誌

Tanaka E, Ogawa Y, Fujii R, Shimonaka T, Sato Y, Hamazaki T, Nagamura-Inoue T, Shintaku H, Tsuji M

Scientific reports 10 巻 ( 1 ) 頁： 21881 - 21881 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Ischemic brain injury provokes complex, time-dependent downstream pathways that ultimately lead to cell death. We aimed to demonstrate the levels of a wide range of metabolites in brain lysates and their on-tissue distribution following neonatal stroke and cell therapies. Postnatal day 12 mice underwent middle cerebral artery occlusion (MCAO) and were administered 1 × 105 cells after 48 h. Metabolomic analysis of the injured hemisphere demonstrated that a variety of amino acids were significantly increased and that tricarboxylic acid cycle intermediates and some related amino acids, such as glutamate, were decreased. With the exception of the changes in citric acid, neither mesenchymal stem/stromal cells nor CD34+ cells ameliorated these changes. On-tissue visualization with matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) imaging revealed that the signal intensity of glutamate was significantly decreased in the infarct area, consistent with the metabolomic analysis, while its intensity was significantly increased in the peri-infarct area after MCAO. Although cell therapies did not ameliorate the changes in metabolites in the infarct area, mesenchymal stem cells ameliorated the increased levels of glutamate and carnitine in the peri-infarct area. MALDI-MS imaging showed the location-specific effect of cell therapies even in this subacute setting after MCAO. These methodologies may be useful for further investigation of possible treatments for ischemic brain injury.

DOI： 10.1038/s41598-020-78930-x

Web of Science

PubMed

Mesenchymal stem/stromal cells stably transduced with an inhibitor of CC chemokine ligand 2 ameliorate bronchopulmonary dysplasia and pulmonary hypertension. 査読有り国際誌

Suzuki T, Sato Y, Yamamoto H, Kato T, Kitase Y, Ueda K, Mimatsu H, Sugiyama Y, Onoda A, Saito S, Takahashi Y, Nakayama T, Hayakawa M

Cytotherapy 22 巻 ( 4 ) 頁： 180 - 192 2020年4月

Autologous cord blood cell therapy for neonatal hypoxic-ischaemic encephalopathy: a pilot study for feasibility and safety. 査読有り国際誌

Tsuji M, Sawada M, Watabe S, Sano H, Kanai M, Tanaka E, Ohnishi S, Sato Y, Sobajima H, Hamazaki T, Mori R, Oka A, Ichiba H, Hayakawa M, Kusuda S, Tamura M, Nabetani M, Shintaku H

Scientific reports 10 巻 ( 1 ) 頁： 4603 - 4603 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Neonatal hypoxic-ischaemic encephalopathy (HIE) is a serious condition; many survivors develop neurological impairments, including cerebral palsy and intellectual disability. Preclinical studies show that the systemic administration of umbilical cord blood cells (UCBCs) is beneficial for neonatal HIE. We conducted a single-arm clinical study to examine the feasibility and safety of intravenous infusion of autologous UCBCs for newborns with HIE. When a neonate was born with severe asphyxia, the UCB was collected, volume-reduced, and divided into three doses. The processed UCB was infused at 12-24, 36-48, and 60-72 hours after the birth. The designed enrolment was six newborns. All six newborns received UCBC therapy strictly adhering to the study protocol together with therapeutic hypothermia. The physiological parameters and peripheral blood parameters did not change much between pre- and postinfusion. There were no serious adverse events that might be related to cell therapy. At 30 days of age, the six infants survived without circulatory or respiratory support. At 18 months of age, neurofunctional development was normal without any impairment in four infants and delayed with cerebral palsy in two infants. This pilot study shows that autologous UCBC therapy is feasible and safe.

DOI： 10.1038/s41598-020-61311-9

Web of Science

PubMed

A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats. 査読有り国際誌

Kitase Y, Sato Y, Ueda K, Suzuki T, Mikrogeorgiou A, Sugiyama Y, Matsubara K, Tsukagoshi Okabe Y, Shimizu S, Hirata H, Yukawa H, Baba Y, Tsuji M, Takahashi Y, Yamamoto A, Hayakawa M

Stem cells and development 29 巻 ( 2 ) 頁： 63 - 74 2020年1月

Establishment of a Novel Fetal Growth Restriction Model and Development of a Stem-Cell Therapy Using Umbilical Cord-Derived Mesenchymal Stromal Cells. 査読有り国際誌

Kitase Y, Sato Y, Arai S, Onoda A, Ueda K, Go S, Mimatsu H, Jabary M, Suzuki T, Ito M, Saito A, Hirakawa A, Mukai T, Nagamura-Inoue T, Takahashi Y, Tsuji M, Hayakawa M

Frontiers in cellular neuroscience 14 巻頁： 212 - 212 2020年

Risk factors for absence of catch-up growth in small for gestational age very low-birthweight infants. 査読有り国際誌

Arai S, Sato Y, Muramatsu H, Yamamoto H, Aoki F, Okai Y, Kataoka S, Hanada Y, Hamada M, Morimoto Y, Kojima S, Natsume J, Takahashi Y, Nagoya Collaborative Clinical Research Team

Pediatrics international : official journal of the Japan Pediatric Society 61 巻 ( 9 ) 頁： 889 - 894 2019年9月

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