Updated on 2022/11/01

写真a

 
NAKAMURA, Masanao
 
Organization
Nagoya University Hospital Diagnostic and Therapeutic Endoscopy Associate professor
Graduate School
Graduate School of Medicine
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. PhD ( 2007.6 ) 

Research Interests 6

  1. 潰瘍性大腸炎

  2. クローン病

  3. clinical research using capsule endoscopy

  4. clinical feature of follicular lymphoma with GI tract

  5. clinical management and research for small bowel diseases

  6. ダブルバルーン内視鏡

Research Areas 1

  1. Life Science / Gastroenterology  / inflammatory bowel disease, small bowel disease

Current Research Project and SDGs 5

  1. 潰瘍性大腸炎とクローン病の臨床研究

  2. 炎症腸粘膜における上皮と腸内環境の関係

  3. hyperpermeability in irritable bowel syndrome

  4. カプセル内視鏡の応用- 大腸検査、小腸狭窄への対応など

  5. 難治性腸疾患に対する便移植

Research History 3

  1. Nagoya University   Lecturer

    2020.1

  2. 名古屋大学医学部付属病院   消化器内科   病院講師

    2018.4

  3. 名古屋大学消化器内科   助教

    2014.2 - 2018.3

Professional Memberships 9

  1. 日本内科学会   総合内科専門医、指導医

  2. 日本消化器病学会   専門医、指導医、学会評議員、東海支部学内幹事

  3. 日本消化器内視鏡学会   専門医、指導医、学会評議員、卒後教育委員、和文誌編集委員

  4. 日本消化管学会   胃腸科専門医、指導医、代議員、学会賞選考委員

  5. 日本カプセル内視鏡学会   専門医、指導医、情報委員、読影トレーニング委員、認定制度委員、学術委員

  6. 日本超音波医学会

  7. 日本炎症性腸疾患学会

  8. 日本消化器がん検診学会

  9. 日本小腸学会   評議員

▼display all

Awards 3

  1. Best Reviewers award 2018

    2019.5   Digestive Endoscopy  

    Masanao Nakamura

     More details

    Award type:Award from publisher, newspaper, foundation, etc. 

  2. 2009年日本消化器内視鏡学会学会賞

    2010.10   日本消化器内視鏡学会  

     More details

    Country:Japan

  3. 第10回消化器病フォーラム優秀賞

    2009.10   消化器病フォーラム  

     More details

    Country:Japan

 

Papers 242

  1. A preliminary result of three-dimensional microarray technology to gene analysis with endoscopic ultrasound-guided fine-needle aspiration specimens and pancreatic juices. Reviewed

    Nonogaki K, Itoh A, Kawashima H, Ohno E, Ishikawa T, Matsubara H, Itoh Y, Nakamura Y, Nakamura M, Miyahara R, Ohmiya N, Ishigami M, Katano Y, Goto H, Hirooka Y.

    J Exp Clin Cancer Res.   Vol. 25   page: 29-36   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  2. Usefulness of EUS combined with contrast-enhancement in the differential diagnosis of malignant versus benign and preoperative localization of pancreatic endocrine tumors. Reviewed

    Ishikawa T, Itoh A, Kawashima H, Ohno E, Matsubara H, Itoh Y, Nakamura Y, Nakamura M, Miyahara R, Hayashi K, Ishigami M, Katano Y, Ohmiya N, Goto H, Hirooka Y.

    Gastrointest Endosc.   Vol. 75   page: 951-959   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  3. Confocal endomicroscopy for phenotypic diagnosis of gastric cancer. Reviewed

    Banno K, Niwa Y, Miyahara R, Nakamura M, Nagaya T, Nagasaka T, Watanabe O, Ando T, Kawashima H, Ohmiya N, Itoh A, Hirooka Y, Goto H.

    J Gastroenterol Hepatol.   Vol. 25   page: 712-718   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  4. Restriction-modification systems may be associated with Helicobacter pylori virulence. Reviewed

    Ando T, Ishiguro K, Watanabe O, Miyake N, Kato T, Hibi S, Mimura S, Nakamura M, Miyahara R, Ohmiya N, Niwa Y, Goto H.

    J Gastroenterol Hepatol.   Vol. 25   page: S95-98   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  5. Route selection for double-balloon endoscopy, based on capsule transit time, in obscure gastrointestinal bleeding. Reviewed

    Nakamura M, Ohmiya N, Shirai O, Takenaka H, Morishima K, Miyahara R, Ando T, Watanabe O, Kawashima H, Itoh A, Hirooka Y, Goto H.

    J Gastroenterol.   Vol. 45   page: 592-599   2010

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  6. Establishment of an interpretation system for video capsule endoscopy for obscure gastrointestinal bleeding. Reviewed

    Goto H, Nakamura M, Ohmiya N, Hirooka Y, Itoh A.

    J Gastroenterol.   Vol. 45   page: 468-469   2010

     More details

    Language:English  

  7. Advance of Video Capsule Endoscopy and the Detection of Anatomic Landmarks. Reviewed

    Nakamura M, Ohmiya N, Shirai O, Takenaka H, Kenji, Morishima, Miyahara R, Ando T,Watanabe O, Kawashima H, Itoh A, Hirooka Y, Niwa Y, Goto H.

    Hepatogastroenterology.   Vol. 56   page: 1600-1605   2009

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  8. Pilot study on confocal endomicroscopy for determination of the depth of squamous cell esophageal cancer on vivo. Reviewed

    Iguchi Y, Niwa Y, Miyahara R, Nakamura M, Banno K, Nagaya T, Nagasaka T, Watanabe O, Ando T, Kawashima H, Ohmiya N, Itoh A, Hirooka Y, Goto H.

    J Gastroenterol and Hepatol.   Vol. 24   page: 1733-1739   2009

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  9. Role of endoscopic ultrasonography in predicting the response to cyclosporin A in ulcerative colitis refractory to steroids. Reviewed

    Watanabe O, Ando T, El-Omar EM, Shimada M, Ina K, Ishiguro K, Hasegawa M, Miyake N, Nakamura M, Miyahara R, Ohmiya N, Niwa Y, Goto H.

    Dig Liver Dis.   Vol. 41   page: 735-739   2009

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  10. Diagnosis of Pancreatic Discorders Using Contrast-Enhanced Endoscopic Ultrasonography and Endoscopic Elastography. Reviewed

    Hirooka Y, Itoh A, Kawashima H, Ohno E, Ishikawa T, Matsubara H, Itoh Y, Nakamura M, Miyahara R, Ohmiya N, Niwa Y, Ishigami M, Katano Y, Goto H.

    Clin Gastroenterol and Hepatol.   Vol. 7   page: S63-67   2009

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  11. 原因不明の消化管出血例におけるカプセル内視鏡の診断的意義 Reviewed

    中村正直、大宮直木、宮原良二、安藤貴文、渡辺修、川嶋啓揮、伊藤彰浩、廣岡芳樹、丹羽康正、後藤秀実

    日本消化器内視鏡学会雑誌   Vol. 51 ( 11 ) page: 2866-2875   2009.11

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  12. Geranylgeranylacetone Protects against Diclofenac-Induced Gastric and Small Intestinal Mucosal Injuries in Healthy Subjects: A Prospective Randomized Placebo-Controlled Double-Blind Cross-Over Study. Reviewed

    Niwa, Y., Nakamura, M., Miyahara, R., Ohmiya, N., Watanabe, O., Ando, T., Kawashima, H., Itoh, A., Hirooka, Y., Goto, H..

    Digestion   Vol. 80 ( 4 ) page: 260-266   2009.10

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  13. Outcome after enteroscopy for patients with obscure GI bleeding: diagnostic comparison between double-balloon endoscopy and videocapsule endoscopy. Reviewed

    Gastrointestinal Endoscopy   Vol. 69 ( 4 ) page: 875-876   2009.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  14. Small-bowel obstruction: diagnostic comparison between double-balloon endoscopy and fluoroscopic enteroclysis, and the outcome of enteroscopic treatment. Reviewed

    Ohmiya, N., Arakawa, D., Nakamura, M., Honda, W.,Shirai, O., Taguchi, A., Itoh, A., Hirooka, Y., Niwa, Y., Maeda, O., Ando, T., Goto, H.,

    Gastrointestinal Endoscopy   Vol. 69 ( 1 ) page: 84-93   2009.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  15. "NEW INSTRUMENTS AND TECHNIQUESNEW OBJECTIVE EVALUATION METHOD FOR FUNCTIONAL BOWEL DISORDER USING VIDEO CAPSULE ENDSCOPY" Reviewed

    Nakamura, M., Niwa, Y., Yagihara, M., Ohmiya, N.,Miyahara, R., Ando, T., Watanabe, O., Kawashima, H., Itoh, A., Hirooka, Y., Fujimoto. H., Goto, H.,

    Digestive Endoscopy   Vol. 21 ( 1 ) page: 29-33   2009.1

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  16. Observation of Deworming Process in Intestinal Diphyllobothrium latum Parasitism by Gastrografin Injection Into Jejunum Through Double-Balloon Enteroscope Reviewed

    Ko S, Ohmiya N, Nakamura M, Honda W, Shirai O, Takenaka H, Niwa Y, Goto H.

    Am J Gastroenterol   Vol. 103   page: 2149-2150   2008

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  17. Efficacy of rebamipide for diclofenac-induced small-intestinal mucosal injuries in healthy subjects: a prospective,rando mized,double-blinded,placebo-controlled,cross-over study Reviewed

    Niwa, Y., Nakamura, M., Ohmiya, N., Maeda, O., Ando, T., Itoh, A., Hirooka, Y., Goto, H.,

    J Gastroenterol   Vol. 43 ( 4 ) page: 270-276   2008.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  18. Which route should we select when performing double-ballon enteroscopy? Reviewed

    Nakamura, M., Niwa, Y., Ohmiya, N., Goto, H.

    Gastrointestinal Endoscopy   Vol. 3 ( 67 ) page: 577-578   2008.3

     More details

    Authorship:Lead author   Language:English  

  19. Analysis of Large Bowel Peristalsis with Video Capsule Endoscopy. Reviewed

    Yagihashi M, Niwa Y, Nakamura M, Goto H, Fujimoto H.

    Complex Medical Engineering     page: 766–769   2007

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  20. Small bowel tuberculosis diagnosed by the combination of video capsule endoscopy and double balloon enteroscopy Reviewed

    Nakamura, M., Niwa, Y., Ohmiya, N., Arakawa, D., Honda, W., Miyahara, R., Matsuura, T., Ando, T., Maeda, O., Itoh, A., Hirooka, Y., Goto, H.

    European Journal of Gastroenterology & Hepatology   Vol. 19 ( 7 ) page: 595-598   2007.7

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  21. Diagnosis and treatment of obscure GI bleeding at double balloon endoscopy Reviewed

    Naoki Ohmiya,Tomonori Yano,Hironori Yamamoto,Daigo Arakawa, Masanao Nakamura,Wataru Honda,Akihiro Itoh,Yoshiki Hirooka,Yasumasa Niwa,Osamu Maeda,Takafumi Ando,Tsuneyoshi Matsui,Mitsuo Iida,Shinji Tanaka,Tsutomu Chiba,Choitsu Sakamoto,Kantaro Sugano,Hidemi Goto.

    Gastrointestinal Endoscopy   Vol. 66 ( 3 ) page: S72-S77   2007.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  22. Ilealcancer and erosions in small intestine revealed by capsule endoscopy. Reviewed

    Niwa Y, Nakamura M, Omiya N, Itoh A, Hirooka Y, Goto H

    Endoscopy   Vol. 38   page: E91-92   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  23. * Preliminary comparison of Capsule Endoscopy and Double-Balloon Enteroscopy in Patients with suspected Small-Bowel Bleeding Reviewed

    Nakamura, M., Niwa, Y., Ohmiya, N., Miyahara, R., Ohashi, A., Itoh, A., Hirooka, Y., Goto, H.

    Endoscopy   Vol. 38 ( 1 ) page: 59-66   2006.1

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  24. Endscopic resection of Peutz-Jeghers polips throughout the small intestine at double-balloon enteroscopy without laparotomy Reviewed

    Ohmiya,N., Taguchi, A., Shirai, K., Mabuchi, N., Arakawa, D., Kanazawa, H., Ozeki, M., Yamada, M.,Nakamura, M., Itoh, A., Hirooka, Y., Niwa, Y., (Nagasaka, T., Ito, M., Ohashi, S., Okamura, S.,Goto, H.,

    Gastrointestinal Endoscopy   Vol. 61 ( 1 ) page: 140-148   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  25. Differences in the intestinal microbiome associated with diarrhea during lenvatinib treatment for hepatocellular carcinoma.

    Inukai Y, Yamamoto K, Honda T, Ito T, Imai N, Ishizu Y, Nakamura M, Kawashima H, Ishigami M

    Digestive diseases (Basel, Switzerland)     2022.3

     More details

    Language:English  

    DOI: 10.1159/000524298

    PubMed

  26. Patients with low muscle mass have characteristic microbiome with low potential for amino acid synthesis in chronic liver disease.

    Yamamoto K, Ishizu Y, Honda T, Ito T, Imai N, Nakamura M, Kawashima H, Kitaura Y, Ishigami M, Fujishiro M

    Scientific reports   Vol. 12 ( 1 ) page: 3674   2022.3

     More details

    Language:English   Publisher:Scientific Reports  

    Sarcopenia is thought to be related to the microbiome, but not enough reports in chronic liver disease (CLD) patients. In addition to the differences in microbiome, the role of the microbiome in the gut is also important to be clarified because it has recently been shown that the microbiome may produce branched-chain amino acids (BCAAs) in the body. In this single-center study, sixty-nine CLD patients were divided by skeletal muscle mass index (SMI) into low (L-SMI: n = 25) and normal (N-SMI: n = 44). Microbiome was analyzed from stool samples based on V3-4 region of bacterial 16S rRNA). L-SMI had a lower Firmicutes/Bacteroidetes ratio than N-SMI. At the genus level, Coprobacillus, Catenibacterium and Clostridium were also lower while the Bacteroides was higher. Predictive functional profiling of the L-SMI group showed that genes related to nitrogen metabolism were enriched, but those related to amino acid metabolism, including BCAA biosynthesis, were lower. The genes related to 'LPS biosynthesis' was also higher. The microbiome of CLD patients with low muscle mass is characterized not only by high relative abundance of gram-negative bacteria with LPS, but also by the possibility of low potential for amino acid synthesis including BCAAs.

    DOI: 10.1038/s41598-022-07810-3

    Scopus

    PubMed

  27. Changes in the gut microbiome in relation to the degree of gastric mucosal atrophy before and after Helicobacter pylori eradication

    Furune Satoshi, Yamamoto Kenta, Honda Takashi, Fujiyoshi Toshihisa, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Nakamura Masanao, Miyahara Ryoji, Kawashima Hiroki, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   Vol. 57 ( 3 ) page: 266 - 273   2022.3

     More details

    Language:Japanese   Publisher:Scandinavian Journal of Gastroenterology  

    Objectives: Helicobacter pylori infection causes atrophic gastritis, which affects the gut microbiome; the gastric acid concentration depends on the degree of atrophic gastritis. Helicobacter pylori eradication also affects gastric acidity. Here, we determined the differences in the post-eradication changes in the gut microbiome in relation to the progression of gastric atrophy. Materials and Methods: Ten patients were included in the closed group and five in the open group, consisting of patients with non-progressive and progressive atrophy, respectively, diagnosed by endoscopy. The faecal microbiome was analysed and compared among three time-points: before eradication, 8 weeks after eradication, and 6 months after eradication. The microbiome was analysed by targeting 16S rRNA using Illumina Miseq. Results: The relative abundance of 14 genera significantly differed between the closed and open groups before eradication, but only 12 and 6 genera presented a significant difference in the relative abundance at 8 weeks and 6 months after eradication, respectively. Of the 12 genera that differed between the closed and open groups before eradication, 8 genera, namely, Actinomyces, Aggregatibacter, Campylobacter, Granulicatella, Pyramidobacter, Streptococcus, Cardiobacterium, and Haemophilus, were oral-origin bacteria. Longitudinal changes showed that Haemophilus and Catenibacterium were consistently significantly more abundant in the open group than in the closed group during the follow-up period. Conclusion: The gut microbiome substantially differed depending on the progression of gastric atrophy, but this difference was decreased by eradication, especially the differences in the number of oral bacteria in the gut. Eradication therapy may improve dysbiosis that result from gastric atrophy.

    DOI: 10.1080/00365521.2021.2005135

    Web of Science

    Scopus

    PubMed

  28. Fecal incontinence and oral regurgitation during duodenal endoscopic submucosal dissection using the water pressure method

    Takada Yoshihisa, Hirose Takashi, Nishida Kazuki, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   Vol. 34 ( 3 ) page: 526 - 534   2022.3

     More details

    Language:Japanese   Publisher:Digestive Endoscopy  

    Objectives: Endoscopic submucosal dissection (ESD) in the duodenum is challenging. The water pressure method (WP-ESD) has been developed with a decreased rate of perforation. However, details of perioperative adverse events of WP-ESD are unknown. The purpose of this study was to clarify the frequency and related factors of fecal incontinence and oral regurgitation during WP-ESD. Methods: A chart-based retrospective analysis was performed on 43 patients who underwent duodenal WP-ESD. The saline volume given into the body was calculated in all cases. All adverse events during WP-ESD until 6 weeks were extracted, and factors related to intraoperative fecal incontinence or oral regurgitation were analyzed. The frequency of fecal incontinence and oral regurgitation was also compared to those of 83 conventional ESD cases. Results: In WP-ESD, intraoperative fecal incontinence occurred in 12 (28%), oral regurgitation in six (14%), and aspiration pneumonia in one patient. For fecal incontinence, the infusion speed (saline volume divided by resection time) around 17 mL/min was a significant factor in multivariable analysis. For oral regurgitation, only tumor size was a significant factor in univariate analysis (P = 0.027). Significant difference was observed in the frequency of fecal incontinence between WP-ESD and conventional ESD (28% vs. 0%, P < 0.001), but no difference was observed in oral regurgitation or aspiration pneumonia. Conclusions: Intraoperative fecal incontinence is a unique adverse event of WP-ESD related to the infusion speed. WP-ESD did not pose a risk for oral regurgitation, but we should be aware of the risk in large tumor cases.

    DOI: 10.1111/den.14070

    Web of Science

    Scopus

    PubMed

  29. Safety and efficacy of the endoscopic delivery of capsule endoscopes in adult and pediatric patients: Multicenter Japanese study (AdvanCE-J study).

    Ohmiya N, Oka S, Nakayama Y, Iwama I, Nakamura M, Shimizu H, Sumioka A, Abe N, Kudo T, Osawa S, Honma H, Okuhira T, Mtsufuji S, Imaeda H, Ota K, Matsuoka R, Hotta N, Inoue M, Nakaji K, Takamaru H, Ozeki K, Kobayashi T, Hosoe N, Tajiri H, Tanaka S

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 34 ( 3 ) page: 543 - 552   2022.3

     More details

    Language:English   Publisher:Digestive Endoscopy  

    Background and Aim: We retrospectively determined the safety and efficacy of the endoscopic delivery (ED) of capsule endoscopes. Methods: We enrolled 10,156 patients who underwent small bowel capsule endoscopy (SBCE), 3182 who underwent patency capsule (PC), and 1367 who underwent colon capsule endoscopy (CCE), at 11 gastroenterological and nine pediatric centers. Results: Small bowel capsule endoscopies, PCs, and CCEs were endoscopically delivered to 546 (5.4%), 214 (6.7%), and 14 (1.0%) patients, respectively. Only mild complications occurred for 21.6% (167/774), including uneventful mucosal damage, bleeding, and abdominal pain. Successful ED of SBCE to the duodenum or jejunum occurred in 91.8% and 90.7% of patients aged <16 years and ≥16 years, respectively (P = 0.6661), but the total enteroscopy rate was higher in the first group (91.7%) than in the second (76.2%, P < 0.0001), for whom impossible ingestion (87.3%) was significantly more common than prolonged lodging in the stomach (64.2%, P = 0.0010). Successful PC and CCE delivery to the duodenum occurred in 84.1% and 28.6%, thereafter the patency confirmation rate and total colonoscopy rate was 100% and 61.5%, respectively. The height, weight, and age cutoff points in predicting spontaneous ingestion were 132 cm, 24.8 kg, and 9 years 2 months, respectively, in patients aged <16 years. Patients aged ≥16 years could not swallow the SBCEs mainly due to dysphagia (75.0%); those who retained it in the esophagus due to cardiac disease (28.6%), etc. and in the stomach due to diabetes mellitus (15.7%), etc. Conclusions: This large-scale study supports the safety and efficacy of ED in adult and pediatric patients. UMIN000042020.

    DOI: 10.1111/den.14104

    Scopus

    PubMed

  30. The impact of the age-adjusted Charlson comorbidity index as a prognostic factor for endoscopic papillectomy in ampullary tumors

    Takada Yoshihisa, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Ito Akihiro, Hirooka Yoshiki

    JOURNAL OF GASTROENTEROLOGY   Vol. 57 ( 3 ) page: 199 - 207   2022.3

     More details

    Language:Japanese   Publisher:Journal of Gastroenterology  

    Background: The prognostic nutritional index (PNI) and Charlson comorbidity index (CCI) have been useful for predicting the prognosis based on nutritional condition and comorbidities in surgery and endoscopic mucosal dissection. The age-adjusted CCI (ACCI) has also been reported to be useful in surgery, but it has not been applied to endoscopic treatment. We therefore clarified the prognostic factors associated with ampullary tumors treated with endoscopic papillectomy (EP). Methods: From January 2003 to December 2020, 236 patients who underwent EP for sporadic ampullary tumors at Nagoya University Hospital were included in this study. The 5-year survival and ability to predict the prognosis were evaluated in terms of the sex, PNI, ACCI, final pathological diagnosis, and intraductal extension. Results: During a median follow-up period of 1558 days, 17 patients died. No patient died of the primary disease. The 5-year survival rate was 91.1%. In a univariate analysis, only a high ACCI (≥ 5) was extracted as a significant prognostic factor (Odds ratio, 12.2; 95% confidence interval, 3.81–39.3; p < 0.001). The 5-year survival rates for a low ACCI (≤ 4) and high ACCI were 96.6% and 73.5%, respectively (p < 0.001). Conclusions: A high ACCI is an important prognostic factor associated with the 5-year survival and a risk of death from other illness. Ampullary tumors suitable for EP are less likely to be a prognostic factor, and treatment-free follow-up may be acceptable in patients with a high ACCI.

    DOI: 10.1007/s00535-022-01853-z

    Web of Science

    Scopus

    PubMed

  31. Artificial intelligence-based diagnosis of upper gastrointestinal subepithelial lesions on endoscopic ultrasonography images.

    Hirai K, Kuwahara T, Furukawa K, Kakushima N, Furune S, Yamamoto H, Marukawa T, Asai H, Matsui K, Sasaki Y, Sakai D, Yamada K, Nishikawa T, Hayashi D, Obayashi T, Komiyama T, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Ishigami M, Fujishiro M

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 25 ( 2 ) page: 382 - 391   2022.3

     More details

    Language:English   Publisher:Gastric Cancer  

    Background: Endoscopic ultrasonography (EUS) is useful for the differential diagnosis of subepithelial lesions (SELs); however, not all of them are easy to distinguish. Gastrointestinal stromal tumors (GISTs) are the commonest SELs, are considered potentially malignant, and differentiating them from benign SELs is important. Artificial intelligence (AI) using deep learning has developed remarkably in the medical field. This study aimed to investigate the efficacy of an AI system for classifying SELs on EUS images. Methods: EUS images of pathologically confirmed upper gastrointestinal SELs (GIST, leiomyoma, schwannoma, neuroendocrine tumor [NET], and ectopic pancreas) were collected from 12 hospitals. These images were divided into development and test datasets in the ratio of 4:1 using random sampling; the development dataset was divided into training and validation datasets. The same test dataset was diagnosed by two experts and two non-experts. Results: A total of 16,110 images were collected from 631 cases for the development and test datasets. The accuracy of the AI system for the five-category classification (GIST, leiomyoma, schwannoma, NET, and ectopic pancreas) was 86.1%, which was significantly higher than that of all endoscopists. The sensitivity, specificity, and accuracy of the AI system for differentiating GISTs from non-GISTs were 98.8%, 67.6%, and 89.3%, respectively. Its sensitivity and accuracy were significantly higher than those of all the endoscopists. Conclusion: The AI system, classifying SELs, showed higher diagnostic performance than that of the experts and may assist in improving the diagnosis of SELs in clinical practice.

    DOI: 10.1007/s10120-021-01261-x

    Scopus

    PubMed

  32. 今月の主題 炎症性腸疾患の粘膜治癒を再考する 主題 Crohn病における小腸粘膜治癒評価の意義-小腸カプセル内視鏡の立場から

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 石川 恵里, 角嶋 直美, 古川 和宏, 飯田 忠, 水谷 泰之, 石川 卓哉, 大野 栄三郎, 川嶋 啓揮, 藤城 光弘

    胃と腸   Vol. 57 ( 2 ) page: 183 - 189   2022.2

     More details

    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1403202660

    CiNii Research

  33. Effects of steroid use for stenosis prevention after endoscopic submucosal dissection for cervical esophageal cancer

    Muroi Koichi, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ito Nobuhito, Hirose Takashi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Funasaka Kohei, Miyahara Ryoji, Fujishiro Mitsuhiro

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY     2022.2

     More details

    Language:Japanese   Publisher:International Journal of Clinical Oncology  

    Background and aim: Esophageal stenosis is a serious complication after endoscopic submucosal dissection (ESD) for thoracic esophageal cancer (TEC), and steroid has been applied for stenosis prevention. However, the rate of stenosis and effect of steroid for ESD of cervical esophageal cancer (CEC) remain unknown. The aim was to clarify the rate and managements of post-ESD stenosis for CEC. Methods: A total of 325 lesions with 272 patients who underwent ESD for esophageal cancers were enrolled and were divided to the CEC group (43 lesions) or the TEC group (282 lesions). Patient characteristics, clinicopathological features, procedure-related outcomes of esophageal ESD, stenosis rate and clinical outcome of steroid use cases were evaluated. Results: More patients in the CEC group received preventive steroid treatment compared to the TEC group (37.2% vs 14.5%, P = 0.001). The rate of post-ESD stenosis tended to be higher in the CEC group (11.6%) than in the TEC group (6.7%). For cases of 3/4 ≤ of circumference, local injection with oral steroid had lower stenosis rate than local injection only in both groups (CEC 40% vs 100%, TEC 30.7% vs 56.3%). More sessions and longer duration of dilation were needed to release the stenosis in the CEC group (20 times vs. 5 times, P = 0.015; 196 days vs. 55 days, P = 0.043). Conclusion: The post-ESD stenosis rate of CEC tended to be higher than that of TEC. More intensive preventive measures for post-ESD stenosis may be needed for CEC than TEC.

    DOI: 10.1007/s10147-022-02139-3

    Web of Science

    Scopus

    PubMed

  34. Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients

    Nakamura Masanao, Maeda Keiko, Yamamoto Kenta, Yamamura Takeshi, Sawada Tsunaki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki

    DIGESTION     page: 1 - 12   2022.2

     More details

    Language:Japanese   Publisher:Digestion  

    Background: The pathophysiology of ulcerative colitis (UC) remains unclear, but early lesions on the colorectal mucosal surface may play an important role in its etiology. Intestinal mucus samples, including inner and outer layers, are collected by net or brush catheters, but the quality of the samples obtained by each method has not been fully investigated. Objective: The purpose of this study was to compare the microbiome and protein content of intestinal mucus collected by net and brush catheters during colonoscopy. Methods: Intestinal mucus samples from the lower rectum of 4 patients with UC were collected using a net catheter, a brush catheter, and intestinal fluid suction. Microbiome and protein content were analyzed using 16S rRNA gene sequencing and mass spectrometry. Results: The patients demonstrated significant differences in microbiome alpha diversity (p < 0.05), but this difference was not observed between the sampling methods. Net catheter samples demonstrated higher total protein concentrations than brush catheter samples. The brush catheter group had more Lachnospira, a butyrate-producing bacterium, when compared to the net group. The brush catheter group also had more oral bacteria of Staphylococcus and Dialister in those with active phase when compared to the net group. Conclusions: Brush catheters are more likely to collect the intestinal mucus inner layer, whereas net catheters are more likely to collect larger samples that include the outer mucus layer, as well as the intestinal fluid. Two sampling methods with different types of collection of the mucosa may lead to different results among patients with mucosal vulnerabilities.

    DOI: 10.1159/000521929

    Web of Science

    Scopus

    PubMed

  35. Immunoproliferative Small Intestinal Disease Diagnosed by Double-balloon Endoscopy with Biopsy Sampling

    Meza Miguel Ricardo Rodríguez, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi

    Internal Medicine   Vol. advpub ( 0 )   2022.2

     More details

    Language:English   Publisher:The Japanese Society of Internal Medicine  

    <p>We herein report an 80-year-old man diagnosed with immunoproliferative small intestine disease (IPSID) via small bowel endoscopy with a biopsy. He developed persistent diarrhea and subsequently presented with hypoproteinemia and moderate anemia. Transanal double-balloon endoscopy showed prominent villous edema in the middle and lower ileum, while a histological examination showed high lymphocyte/plasma cell infiltration in the mucosal layer. Furthermore, an immunostaining analysis showed that CD3 and CD20 were partially positive, while CD138 was diffusely positive. Immunoglobulin A positivity was also observed. He was diagnosed with IPSID and received a nutritional agent and minocycline. After three months, the patients' symptoms improved. </p>

    DOI: 10.2169/internalmedicine.8847-21

    PubMed

    CiNii Research

  36. Factors related to delayed adverse events of endoscopic submucosal dissection in the duodenum.

    Kawamura T, Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M

    Digestive diseases (Basel, Switzerland)     2022.2

     More details

    Language:English  

    DOI: 10.1159/000522362

    PubMed

  37. Gastrointestinal: Idiopathic omental hemorrhage

    Furukawa K., Yamamura T., Nakamura M., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 37 ( 2 ) page: 282 - 282   2022.2

     More details

    Language:Japanese   Publisher:Journal of Gastroenterology and Hepatology (Australia)  

    DOI: 10.1111/jgh.15639

    Web of Science

    Scopus

  38. Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 169 - 179   2022.2

     More details

    Language:Japanese   Publisher:Nagoya Journal of Medical Science  

    Ulcerative colitis (UC) is an incurable, chronic inflammatory disease of the large bowel whose etiology and pathogenesis have not yet been comprehensively explained. Tofacitinib is a small molecule Janus kinase inhibitor that was introduced for treating refractory UC. We aimed to examine the efficacy and safety of tofacitinib for the treatment of 18 patients with UC. Continuous treatment rates were 50, 38, and 33% at 8, 24, and 52 weeks, respectively. Overall, 83.3% of these patients showed tumor necrosis factor (TNF) antibody failure status. When the effective status was defined as a Lichtiger index (LI) that decreased by 3 points or more or was less than 4 points and remission status was defined as an LI less than 4 points, the effective and remission rates (%) at 2, 8, and 16 weeks were 55.5 (10/18) and 22.2 (4/18), 38.8 (7/18) and 33.3 (6/18), and 38.8 (7/18) and 38.8 (7/18), respectively. Background characteristics of 2-week responders and non-responders were compared. C-reactive protein level in responders was significantly lower than that in non-responders, and the hemoglobin level in responders was significantly higher than that in non-responders. This study provides preliminary results of the effectiveness of tofacitinib even for TNF antibody and tacrolimus failure patients.

    DOI: 10.18999/nagjms.84.1.169

    Web of Science

    Scopus

  39. Usefulness of Macroscopic On-Site Evaluation Using a Stereomicroscope during EUS-FNB for Diagnosing Solid Pancreatic Lesions

    Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Uetsuki Kota, Yashika Jun, Yamada Kenta, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Takada Yoshihisa, Takahashi Hidekazu, Aoi Hironori, Kato Katsuyuki, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Hirooka Yoshiki, Kawashima Hiroki

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 2022   page: 2737578   2022.1

     More details

    Language:Japanese   Publisher:Canadian Journal of Gastroenterology and Hepatology  

    Background/Aims. The usefulness of macroscopic on-site evaluation (MOSE) during endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) has been reported, but a specific method for MOSE has not been established. We aimed to investigate the usefulness of MOSE using a stereomicroscope (S-MOSE) for the diagnosis of solid pancreatic lesions (SPLs). Methods. We reviewed a total of 60 consecutive patients who underwent both S-MOSE and rapid on-site cytopathological evaluation (ROSE) during EUS-FNB between July 2019 and October 2020, and the usefulness of S-MOSE in comparison with histology was evaluated. A 22-gauge Franseen needle was used to perform EUS-FNB in all patients, and only the specimens obtained by the first pass were evaluated. The final diagnosis was based on the surgical specimen or the clinical course consistent with the EUS-FNB results. Results. The final diagnoses of the 60 patients included 45 patients with pancreatic ductal adenocarcinoma, 6 with autoimmune pancreatitis, 4 with mass-forming pancreatitis, 1 with pancreatic metastasis, 2 with pancreatic neuroendocrine tumor, and 2 with intraductal papillary mucinous carcinoma. The histological diagnostic accuracy of the first pass of EUS-FNB was 83.3% (50/60). The agreement between the S-MOSE and the histological diagnosis was 90% (54/60). The positive predictive value of S-MOSE for histological diagnosis was 90.7%, which can be an indicator of when to stop the EUS-FNB procedure. There were no immediate or delayed adverse events reported after the FNB based on the chart and medical visit history review. Conclusion. In the EUS-FNB of SPLs, S-MOSE can be an alternative to ROSE for specimen evaluation and has the potential to shorten the procedure time.

    DOI: 10.1155/2022/2737578

    Web of Science

    Scopus

    PubMed

  40. Comparison of outcomes between secondary fully covered and uncovered self-expandable metal stents in the treatment of recurrent biliary obstruction of pancreatic cancer

    Kataoka Kunio, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2022.1

     More details

    Language:Japanese   Publisher:Surgical Endoscopy  

    Background: The overall survival (OS) of pancreatic cancer (PC) has been prolonged by advances in chemotherapy, and the number of cases of recurrent biliary obstruction (RBO) after self-expandable metal stent (SEMS) placement is expected to increase. We herein compared outcomes between secondary fully covered SEMS (FC) and uncovered SEMS (UC) for RBO of PC with FC placed as the 1st SEMS. Methods: Between May 2010 and March 2021, 62 PC patients who underwent SEMS exchange to FC (n = 34) or UC (n = 28) for RBO were retrospectively analyzed. Patient characteristics, OS, time to RBO (TRBO), and stent-related adverse events were compared between the FC and UC groups. Cox’s proportional hazard model was used to identify risk factors for RBO with the 2nd SEMS. Results: There was a significant difference between the FC and UC groups only in the 2nd SEMS diameter. Median OS and TRBO were 195 and 238 days in FC patients and 306 and 455 days in UC patients, respectively, with no significant differences between the two groups. No significant differences were observed in the stent-related adverse event rate. In multivariate analyses, only the 2nd SEMS diameter was significant (P = 0.009). Median TRBO were 455, 238, and 103 days in 10-mm UC, 10-mm FC, and 8-mm UC patients, with 10-mm UC patients having significantly longer TRBO than 10-mm FC and 8-mm UC patients (P = 0.020 and 0.001). Conclusion: SEMS exchange to 10-mm UC may be appropriate for RBO of PC with FC as the 1st SEMS.

    DOI: 10.1007/s00464-021-08981-2

    Web of Science

    Scopus

    PubMed

  41. Relationship between psoas muscle index and long-term survival in older patients aged >= 80 years after endoscopic submucosal dissection for gastric cancer

    Ito Nobuhito, Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 27 ( 4 ) page: 729 - 738   2022.1

     More details

    Language:Japanese   Publisher:International Journal of Clinical Oncology  

    Background: In Japan, endoscopic submucosal dissection (ESD) has been widely performed for ESD-adapted gastric cancer, but little is known about the prognostic factors after ESD for gastric cancer in older patients. The psoas muscle index (PMI) is an indicator of sarcopenia calculated from computed tomography images and reportedly related to the prognosis of some diseases. This study aimed to explore factors related to long-term survival after ESD for gastric cancer in patients aged ≥ 80 years. Methods: We retrospectively reviewed 88 patients (63 men, 25 women) with early gastric cancer who underwent ESD at ≥ 80 years. Possible factors related to death after gastric ESD were analyzed by univariate and multivariate analyses using a Cox proportional hazards model. The estimated overall survival (OS) was compared between the groups stratified by significant factors. Results: The 5-year OS rate was 73.9% (median follow-up period, 5.4 years). In the multivariate analysis, a low PMI (< 6.36 in men, < 3.92 in women) (hazard ratio [HR] 2.89, 95% confidence interval [CI] 1.11–7.54) and high Charlson comorbidity index (CCI) (≥ 3) (HR 1.87, 95% CI 1.14–3.09) were independently related to death after ESD. The 5-year OS rates were significantly higher in the high PMI group (82.3% vs. 70.7%, P = 0.026) and the low CCI group (76.0% vs. 37.9%, P = 0.002). Conclusion: In addition to low CCI, high PMI is a predictor of long-term survival after ESD for gastric cancer in patients aged ≥ 80 years.

    DOI: 10.1007/s10147-021-02112-6

    Web of Science

    Scopus

    PubMed

  42. Evaluation of ulcerative colitis activity using transabdominal ultrasound shear wave elastography

    Yamada Kenta, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Iida Tadashi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Ishigami Masatoshi, Fujishiro Mitsuhiro

    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY   Vol. 12 ( 1 ) page: 618 - 626   2022.1

     More details

    Language:Japanese   Publisher:Quantitative Imaging in Medicine and Surgery  

    Background: Transabdominal ultrasound (US) has been reported to be effective in the evaluation of ulcerative colitis (UC). US can measure shear wave elastography (SWE) and shear wave dispersion (SWD), which may be correlated with inflammation and necrosis. We aimed to investigate the relationship between UC activity and SWE and SWD. Methods: Patients with UC who underwent US within 2 days before or after a colonoscopy between April 2019 and March 2020 were included. SWE and SWD were measured in the sigmoid colon; the correlations of SWE and SWD with the Lichtiger index and the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) were investigated. We also compared SWE and SWD between patients with mucosal healing and those in the active phase according to the UCEIS. Results: Twenty-six UC patients were enrolled. The median Lichtiger index, UCEIS, SWE values, and SWD values were 8 [interquartile range (IQR), 5.3–10.8], 4 (IQR, 3.3–5), 1.69 (IQR, 1.49–2.16) m/s, and 11.9 (IQR, 10.9–13.3) (m/s)/kHz, respectively. The Lichtiger index and UCEIS were negatively correlated with the SWE values (rs=−0.404 and rs=−0.506) but not with the SWD values (rs=0.004 and rs=0.002). The SWE values differed significantly between the mucosal healing and active phase groups [2.40 (IQR, 2.18–3.38) vs. 1.62 (IQR, 1.44–1.95) m/s, P=0.007], whereas the SWD values did not [13.1 (IQR, 7.05–21.6) vs. 11.9 (IQR, 11.1–13.2) (m/s)/kHz, P=0.918]. Conclusions: SWE may be useful for the evaluation of UC activity and could be a noninvasive method of assessing disease severity.

    DOI: 10.21037/qims-21-403

    Web of Science

    Scopus

    PubMed

  43. Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern Era

    Ishikawa Eri, Nakamura Masanao, Satou Akira, Shimada Kazuyuki, Nakamura Shotaro

    CANCERS   Vol. 14 ( 2 )   2022.1

     More details

    Language:Japanese   Publisher:Cancers  

    Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) typically arises from sites such as the stomach, where there is no organized lymphoid tissue. Close associations between Helicobacter pylori and gastric MALT lymphoma or Campylobacter jejuni and immunoproliferative small intestinal disease (IPSID) have been established. A subset of tumors is associated with chromosomal rearrangement and/or genetic alterations. This disease often presents as localized disease, requiring diverse treatment approaches, from antibiotic therapy to radiotherapy and immunochemotherapy. Eradication therapy for H. pylori effectively cures gastric MALT lymphoma in most patients. However, treatment strategies for H. pylori-negative gastric MALT lymphoma are still challenging. In addition, the effectiveness of antibiotic therapy has been controversial in intestinal MALT lymphoma, except for IPSID. Endoscopic treatment has been noted to usually achieve complete remission in endoscopically resectable colorectal MALT lymphoma with localized disease. MALT lymphoma has been excluded from post-transplant lymphoproliferative disorders with the exception of Epstein–Barr virus (EBV)-positive marginal zone lymphoma (MZL). We also describe the expanding spectrum of EBV-negative MZL and a close association of the disease with the gastrointestinal tract.

    DOI: 10.3390/cancers14020446

    Web of Science

    Scopus

    PubMed

  44. Feasibility of endoscopic ultrasonography using a 60-MHz ultrasound miniature probe in the upper gastrointestinal tract

    Asai Hiromitsu, Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Furune Satoshi, Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 49 ( 1 ) page: 61 - 69   2022.1

     More details

    Language:Japanese   Publisher:Journal of Medical Ultrasonics  

    Purpose: The use of higher frequencies in ultrasound allows for a more detailed image. This study aimed to investigate the feasibility of delineating the gastrointestinal wall using a 60-MHz miniature ultrasound probe. Methods: A phantom study was performed using a multipurpose ultrasonic phantom model, and the depth of imaging was evaluated using 60-MHz and 20-MHz miniature probes and 7.5-MHz conventional convex-type endoscopic ultrasonography. A total of 25 visualized areas from a total of 16 specimens from 16 patients were enrolled. The structures of the layers of the esophagus, stomach, and duodenum were evaluated using a 60-MHz probe and a pathological specimen created from endoscopically or surgically resected specimens. Results: The 60-MHz probe was able to render to a depth of 2 mm and visualize the esophagus, stomach, and duodenum in five layers, respectively, within the depiction range. The depiction ranges of the 20-MHz probe and 7.5-MHz conventional endoscopic ultrasonography were 5 mm and 60 mm, respectively. The 60-MHz probe visualized the muscularis mucosae as the fourth layer in the esophagus, the fourth layer in the stomach, and the second layer in the duodenum. Muscularis mucosae were delineated in almost all cases, except in two cases where the layered structure disappeared. Conclusion: The 60-MHz probe provided good visualization of the muscularis mucosae and structure of the layers down to the submucosa, which improves the ability to diagnose the depth of early cancer invasion of the upper gastrointestinal tract, leading to more appropriate treatments.

    DOI: 10.1007/s10396-021-01172-5

    Web of Science

    Scopus

    PubMed

  45. Differentiation Between Solid Pseudopapillary Neoplasm of the Pancreas and Nonfunctional Pancreatic Neuroendocrine Neoplasm Using Endoscopic Ultrasound

    Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    PANCREAS   Vol. 51 ( 1 ) page: 106 - 111   2022.1

     More details

    Language:Japanese   Publisher:Pancreas  

    Objectives We investigated the utility of endoscopic ultrasound (EUS) for differentiating between solid pseudopapillary neoplasm of the pancreas (SPN) and pancreatic neuroendocrine neoplasm (PanNEN). Methods A retrospective analysis was performed on 29 and 77 consecutive patients with pathologically proven SPN and nonfunctional PanNEN. In patients who underwent contrast-enhanced harmonic EUS (CH-EUS), lesions were classified into 3 vascular patterns (hypoechoic/isoechoic/hyperechoic), and the presence of "the alveolus nest sign,"which we previously reported as a characteristic feature of SPN on CH-EUS, was also assessed. Results Conventional EUS findings showed that calcification echoes were significantly more frequent in SPN lesions than in PanNEN lesions (19/29 [66%] vs 21/77 [27%], P = 0.001) as was internal isoechogenicity or hyperechogenicity (10/29 [34%] vs 11/77 [14%], P = 0.029). Contrast-enhanced harmonic EUS findings showed that SPN lesions more frequently had the isoechoic or hypoechoic vascular pattern, and significantly more frequently had the alveolus nest sign (18/25 [72%] vs 4/60 [7%], P < 0.001). In a multivariate analysis, the presence of the alveolus nest sign contributed the most to the SPN diagnosis (odds ratio, 70; 95% confidence interval, 6.2-786). Conclusions Endoscopic ultrasound, particularly the presence of the alveolus nest sign on CH-EUS, is useful for differentiating SPN from PanNEN.

    DOI: 10.1097/MPA.0000000000001966

    Web of Science

    Scopus

    PubMed

  46. Indications and Limitations Associated with the Patency Capsule Prior to Capsule Endoscopy

    Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    Internal Medicine   Vol. 61 ( 1 ) page: 5 - 13   2022

     More details

    Language:Japanese   Publisher:The Japanese Society of Internal Medicine  

    <p>The retention of the capsule used during small bowel capsule endoscopy (SBCE) is a serious complication that can occur in patients with known or suspected small bowel stenosis, and a prior evaluation of the patency of the gastrointestinal (GI) tract is therefore essential. Patency capsule (PC) is a non-diagnostic capsule the same size as the diagnostic SBCE. To date, there are no clear guidelines regarding the contraindications for undergoing a PC evaluation prior to SBCE. Each small bowel disorder has specific occasions to inhibit the progress of PC and SBCE, even though they do not have any stenotic symptoms or abnormalities on imaging. In this review, we summarize the indications and limitations of PC prior to SBCE, especially the contraindications, and discuss clinical scenarios in which even PC should be avoided, and therefore such areas of stenosis should be evaluated by alternative modalities. We thus propose this new algorithm to evaluate the patency of the GI tract for patients with suspected and known small bowel stenosis in order that they may undergo SBCE safely. </p>

    DOI: 10.2169/internalmedicine.6823-20

    Web of Science

    Scopus

    PubMed

    CiNii Research

  47. THE ROLE OF CAPSULE ENDOSCOPY IN THE MANAGEMENT OF CROHN’S DISEASE

    NAKAMURA Masanao, YAMAMURA Takeshi

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 64 ( 2 ) page: 131 - 142   2022

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>The entire small bowel can be visualized non-invasively by capsule endoscopy (CE). Therefore, CE is considered a good tool to evaluate Crohnʼs disease (CD) lesions in the entire small intestine. In contrast, the investigation is associated with a potential risk of capsule retention due to small bowel stenosis; therefore, the appropriate modality should be selected based on the clinical background and patency of the gastrointestinal tract.</p><p>The applications of CE in clinical practice include (1) initial diagnosis of CD and differentiation from other inflammatory diseases, (2) identifying the small intestinal lesions of CD and their distribution, and (3) evaluation of the therapeutic effect and endoscopic monitoring of patients in clinical remission. CD is characterized by conspicuous erosions and small ulcers from the jejunum to the ileum. CE has the highest detection sensitivity of CD in the small intestine compared to other modalities. CE should be performed 6 months after the start of treatment to determine the therapeutic effect. In the event of low endoscopic activity or in cases of remission, laboratory data should be assessed regularly and CE should be performed within 2 years. Diagnosis and monitoring with the appropriate modality, including CE, can ensure long-term maintenance of clinical remission and avoidance of surgery in patients with CD.</p>

    DOI: 10.11280/gee.64.131

    CiNii Research

  48. Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching

    Saito Masashi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Mizutani Yasuyuki, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 27 ( 47 ) page: 8182 - 8193   2021.12

     More details

    Language:Japanese   Publisher:World Journal of Gastroenterology  

    BACKGROUND Cold polypectomy (CP) is a simple and safe procedure for polyps less than 10 mm in size; however, there is concern about local recurrence following CP because of unidentified margins of excised specimens and the lack of tumor suppression effect by coagulation. Some clinical trials have evaluated local persistent recurrence; their results suggest that a higher rate of local recurrence has not been documented so far. There were few reports that observed the course over long periods of time after CP in clinical practice. AIM To evaluate the presence of local recurrence following CP and hot polypectomy (HP) using propensity score matching. METHODS We analyzed 275 patients who underwent polypectomy for non-pedunculated colorectal polyps less than 10 mm (959 Lesions) between October 2016 and 2017 and underwent follow-up endoscopy subsequently. We divided them into the CP group (706 Lesions), wherein CP was performed, and the HP group (253 Lesions), wherein HP was performed. Using propensity score matching, we extracted 215 Lesions in each group and evaluated the local recurrence and content of CP in the real clinic and adverse events using medical records. RESULTS After propensity score matching, there were no significant differences in the patients’ and their endoscopic background (age, use of antithrombotics, indications, size, morphology, location of polyps, and polypectomy device) between the groups. The mean duration between colorectal polypectomy and the next follow-up colonoscopy was 17.5 ± 7.1 (range, 6-39) mo in the CP group and 15.7 ± 6.0 (range, 6-35) mo in the HP group, which was significantly longer in the CP group (P = 0.005). The local recurrence rate was 0.93% in the CP group and 0.93% in the HP group, without a significant difference (P = 0.688). Additionally, no differences were observed in the macroscopic en bloc resection rate, histopathological complete resection rate, and pathological results between the groups. Adverse events did not occur in either group. CONCLUSION Local recurrence after CP was equivalent to that following HP in clinical practice. CP is useful and safe in the treatment of non-pedunculated polyps of less than 10 mm.

    DOI: 10.3748/wjg.v27.i47.8182

    Web of Science

    Scopus

    PubMed

  49. 特集 Cold polypectomyの課題 4.症例からみえた課題(1)小腸ポリープに対するcold polypectomy

    山村 健史, 中村 正直, 前田 啓子, 澤田 つな騎, 石川 恵里, 角嶋 直美, 古川 和宏, 川嶋 啓揮

    臨床消化器内科   Vol. 37 ( 1 ) page: 93 - 96   2021.12

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000002065

    CiNii Research

  50. Changes in the gut microbiota after hepatitis C virus eradication

    Honda Takashi, Ishigami Masatoshi, Yamamoto Kenta, Takeyama Tomoaki, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Ishikawa Tetsuya, Hirooka Yoshiki, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 23568   2021.12

     More details

    Language:Japanese   Publisher:Scientific Reports  

    The gut microbiota interacts with infectious diseases and affects host immunity. Liver disease is also reportedly associated with changes in the gut microbiota. To elucidate the changes in the gut microbiota before and after hepatitis C virus (HCV) eradication through direct-acting antiviral (DAA) treatment in patients with chronic hepatitis C (CHC), we investigated 42 samples from 14 patients who received DAA therapy for HCV. Fecal samples were obtained before treatment (Pre), when treatment ended (EOT), and 24 weeks after treatment ended (Post24). The target V3–4 region of the 16S rRNA gene from fecal samples was amplified using the Illumina Miseq sequencing platform. The diversity of the gut microbiota did not significantly differ between Pre, EOT, and Post24. Principal coordinates analysis showed that for each patient, the values at Pre, EOT, and Post24 were concentrated within a small area. The linear discriminant analysis of effect size showed that the relative abundances of Faecalibacterium and Bacillus increased at EOT, further increased at Post24, and were significantly increased at Post24 compared to Pre. These suggest that changes in the gut microbiota should be considered as among the various effects observed on living organisms after HCV eradication.

    DOI: 10.1038/s41598-021-03009-0

    Web of Science

    Scopus

    PubMed

  51. Obesity and myosteatosis: the two characteristics of dynapenia in patients with cirrhosis

    Sugiyama Yoshiaki, Ishizu Yoji, Ando Yusuke, Yokoyama Shinya, Yamamoto Kenta, Ito Takanori, Imai Norihiro, Nakamura Masanao, Honda Takashi, Kawashima Hiroki, Ishikawa Tetsuya, Ishigami Masatoshi

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   Vol. 33 ( 1S Suppl 1 ) page: E916 - E921   2021.12

     More details

    Language:Japanese   Publisher:European journal of gastroenterology &amp; hepatology  

    OBJECTIVE: In patients with liver cirrhosis, the clinical characteristics of dynapenia, a condition in which skeletal muscle mass is maintained but muscle strength is reduced, are not yet known. This study aimed to clarify the characteristics of dynapenia and its impact on quality of life (QOL) in patients with liver cirrhosis. METHODS: We retrospectively analyzed 116 patients with cirrhosis. Based on grip strength and skeletal muscle mass measured by the bioelectrical impedance analysis method, patients were divided into four groups: normal muscle status, dynapenia, pre-sarcopenia (a condition involving only low muscle mass), and sarcopenia. The characteristics of dynapenia and its influence on QOL were examined. RESULTS: Fourteen patients had dynapenia. Liver function did not differ among the four groups. In patients with dynapenia, BMI was highest and computed tomography attenuation of skeletal muscle at the third lumbar spine vertebra was lowest among the four groups. The percentage of patients with both BMI ≥25 kg/m2 and myosteatosis was significantly higher in patients with dynapenia [9/14 (64.3%)] than in those with sarcopenia [2/23 (8.7%), P = 0.004] and pre-sarcopenia [0/18 (0%), P < 0.001] and tended to be higher than those with normal muscle status [16/61 (26.2%), P = 0.065]. The physical QOL in patients with dynapenia was as low as that in those with sarcopenia and significantly lower than that in those with normal muscle status. CONCLUSION: Cirrhotic patients with dynapenia had high BMI and myosteatosis, and impaired physical QOL.

    DOI: 10.1097/MEG.0000000000002303

    Web of Science

    Scopus

    PubMed

  52. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival

    Yamada Kentaro, Sawada Tsunaki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Ishikawa Eri, Iida Tadashi, Mizutani Yasuyuki, Kakushima Naomi, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Furune Satoshi, Hase Tetsunari, Yokota Kenji, Maeda Osamu, Hashimoto Naozumi, Akiyama Masashi, Ando Yuichi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 27 ( 41 ) page: 7190 - 7206   2021.11

     More details

    Language:Japanese   Publisher:World Journal of Gastroenterology  

    BACKGROUND Despite the popularity of immune checkpoint inhibitors (ICIs) in the treatment of advanced cancer, patients often develop gastrointestinal (GI) and non-GI immune- related adverse events (irAEs). The clinical characteristics and survival outcomes of GI-irAEs have not been fully elucidated in previous reports. This necessitates the evaluation of the impact of GI-irAEs on patients receiving ICI treatment. AIM To evaluate the clinical characteristics of GI-irAEs and their impact on survival in patients treated with ICIs. METHODS In this single-center, retrospective, observational study, we reviewed the records of 661 patients who received ICIs for various cancers at Nagoya University Hospital from September 2014 to August 2020. We analyzed the clinical characteristics of patients who received ICI treatment. We also evaluated the correlation between GI-irAE development and prognosis in non-small cell lung cancer (LC) and malignant melanoma (MM). Kaplan-Meier analysis was used to compare the median overall survival (OS). Multivariate Cox proportional hazards models were used to identify prognostic factors. A P value < 0.05 was considered statistically significant. RESULTS GI-irAEs occurred in 34 of 605 patients (5.6%) treated with an anti-programmed cell death-1/programmed death-ligand 1 (anti-PD-1/PD-L1) antibody alone and in nine of 56 patients (16.1%) treated with an anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) antibody alone or a combination of anti-PD-1 and anti-CTLA-4 antibodies. The cumulative incidence and median daily diarrhea frequency were significantly higher in patients receiving anti-CTLA-4 antibodies (P < 0.05). In 130 patients with MM, OS was significantly prolonged in the group that continued ICI treatment despite the development of GI-irAEs compared to the group that did not experience GI-irAEs (P = 0.035). In contrast, in 209 patients with non-small cell LC, there was no significant difference in OS between the groups. The multivariate analyses showed that a performance status of 2-3 (hazard ratio: 2.406; 95% confidence interval: 1.125-5.147; P = 0.024) was an independent predictive factor for OS in patients with MM. CONCLUSION Patients receiving anti-CTLA-4 antibodies develop GI-irAEs more frequently and with higher severity than those receiving anti-PD-1/PD-L1 antibodies. Continuing ICI treatment in patients with MM with GI-irAEs have better OS.

    DOI: 10.3748/wjg.v27.i41.7190

    Web of Science

    Scopus

    PubMed

  53. Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine

    Yamamoto Kenta, Honda Takashi, Yokoyama Shinya, Ma Lingyun, Kato Asuka, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Tsuji Noriko M., Fujishiro Mitsuhiro

    DIGESTIVE AND LIVER DISEASE   Vol. 53 ( 11 ) page: 1443 - 1450   2021.11

     More details

    Language:Japanese   Publisher:Digestive and Liver Disease  

    Background & aims: Hepatocellular carcinoma in nonalcoholic steatohepatitis is caused by the complex factors of inflammation, fibrosis and microbiomes. We used network analysis to examine the interrelationships of these factors. Methods: C57Bl/6 mice were categorized into groups: choline-sufficient high-fat (CSHF, n = 8), choline-deficient high-fat (CDHF, n = 9), and CDHF+ diethylnitrosamine (DEN, n = 8). All mice were fed CSHF or CDHF for 20 weeks starting at week 8, and mice in the CDHF + DEN group received one injection of DEN at 3 weeks of age. Bacterial gene was isolated from feces and analyzed using Miseq. Results: The CSHF group had less fibrosis than the other groups. Tumors were found in 22.2% and 87.5% of the CDHF group and CDHF + DEN groups, respectively. Gene expression in the liver of Cdkn1a (p21: tumor-suppressor) and c-jun was highest in the CDHF group. Bacteroides, Roseburia, Odoribacter, and Clostridium correlated with fibrosis. Streptococcus and Dorea correlated with inflammation and tumors. Akkermansia and Bilophila were inversely correlated with fibrosis and Bifidobacterium was inversely correlated with tumors. Conclusions: DEN suppressed the overexpression of p21 caused by CDHF. Some bacteria formed a relationship networking associated with their progression and inhibition for tumors and fibrosis.

    DOI: 10.1016/j.dld.2021.02.013

    Web of Science

    Scopus

    PubMed

  54. Endoscopic resection of a duodenal neuroendocrine tumor.

    Furukawa K, Nakamura M, Kawashima H, Fujishiro M

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva     2021.9

     More details

    Language:English  

    DOI: 10.17235/reed.2021.8232/2021

    PubMed

  55. The role of early video capsule endoscopy in the diagnosis and prognosis of obscure gastrointestinal bleeding: A multi-center propensity score matching study International coauthorship

    Zhao Ran, Nakamura Masanao, Wu Shan, Uchida Genta, Yamamura Takeshi, Gao Yun-Jie, Goto Hidemi, Fujishiro Mitsuhiro, Ge Zhi-Zheng

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 36 ( 9 ) page: 2540 - 2548   2021.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Gastroenterology and Hepatology (Australia)  

    Background and Aim: Video capsule endoscopy (VCE) is a first-line procedure for the diagnosis of obscure gastrointestinal bleeding (OGIB). The opinions on the timing for such diagnostic evaluation remain unclear. We aimed to explore the role of early VCE in OGIB patients. Methods: A total of 997 patients that underwent VCE at Renji Hospital and Nagoya University from May 15, 2002, to December 28, 2016, were included in this study. We matched patients that underwent early VCE within 14 days of bleeding (early group, n = 678) to patients that did not (late group, n = 319) via 1:1 propensity score matching (PSM). We then compared VCE diagnostic rates and the prevalence of post-VCE rebleeding in patients with initial negative VCE findings within 1 year between these groups before and after PSM. Results: Following PSM, early VCE was associated with a significantly higher rate of OGIB diagnosis (56.4% vs 45.5%, P = 0.001) and with a significantly lower incidence of rebleeding within 1 year following treatment (24.7% vs 36.7%, P = 0.041). In univariate and multivariate analyses, VCE timing (odds ratio 0.648; 95% confidence interval 0.496–0.847, P = 0.001 and odds ratio 0.666; 95% confidence interval 0.496–0.894, P = 0.007, respectively) was found to be linked with a higher rate of positive findings. Conclusion: Early VCE can improve the reliability of OGIB diagnosis while also reducing rates of post-VCE rebleeding. This suggests that timely and accurate diagnosis can help to improve OGIB patient treatment and prognosis.

    DOI: 10.1111/jgh.15491

    Web of Science

    Scopus

    PubMed

  56. A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasion

    Kuno Takeshi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Esaki Masaya, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 35 ( 8 ) page: 4389 - 4398   2021.8

     More details

    Language:Japanese   Publisher:Surgical Endoscopy  

    Background: It is important to accurately diagnose the depth of colorectal neoplasia invasion. We aimed to evaluate the usefulness of a new forward-viewing radial-array echoendoscope (FRE), relative to the pit pattern method. Methods: In this prospective study, the invasion depth of suspected early-stage carcinoma was diagnosed using the pit pattern and FRE methods. The diagnoses were classified as T1a (submucosal invasion distance < 1,000 μm) or shallower and T1b (≥ 1,000 μm) or deeper. Pathological diagnoses were used to compare the diagnostic capabilities of the two methods. Results: The final analyses included 110 lesions. The FRE was successfully inserted to the lesion in all cases. There were no significant differences between the two methods regarding the correct prediction rate (79.1% vs. 75.5%, P = 0.57), accuracy (81.3% vs. 79.0%, P = 0.68), specificity (81.3% vs. 70.8%, P = 0.135), positive predictive value (65.0% vs. 60.4%, P = 0.649), negative predictive value (91.0% vs. 98.1%, P = 0.108), or frequency of unevaluable cases (2.7% vs. 4.5%, P = 0.471). The correct prediction rate was calculated by adding the number of unevaluable cases to the denominator of accuracy. Relative to the pit pattern method, the FRE method offered significantly higher sensitivity for predicting T1b or deeper invasion (81.3% vs. 97.0%, P = 0.048). The pit pattern method had significantly poorer accuracy for large lesions (> 36 mm) than for smaller lesions (≤ 36 mm). In contrast, the accuracy of the FRE method did not differ significantly with lesion size. When using the FRE method, no cases were unevaluable because of attenuation. The FRE method provided correct diagnoses in 2 of 3 cases that were unevaluable using the pit pattern method. Conclusions: The pit pattern and FRE methods offered similar diagnostic performance for invasion depth. Furthermore, the FRE method may be used to correctly diagnose cases that are unevaluable using the pit pattern method.

    DOI: 10.1007/s00464-020-07936-3

    Web of Science

    Scopus

    PubMed

  57. Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscon Trial

    Hasegawa Issei, Yamamura Takeshi, Suzuki Hiroto, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Nakamura Masanao, Fujishiro Mitsuhiro

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   Vol. 19 ( 8 ) page: 1708 - +   2021.8

     More details

    Language:Japanese   Publisher:Clinical Gastroenterology and Hepatology  

    Background and aims: A higher adenoma detection rate (ADR) has been shown to be related to a lower incidence and mortality of colorectal cancer. We analyzed the efficacy of linked color imaging (LCI) by assessing the detection, miss, and visibility of various featured adenomas as compared with white light imaging (WLI). Methods: This was a prospective, randomized, tandem trial. The participants were randomly assigned to 2 groups: first observation by LCI, then second observation by WLI (LCI group); or both observations by WLI (WLI group). Suspected neoplastic lesions were resected after magnifying image-enhanced endoscopy. The primary outcome was to compare the ADR during the first observation. Secondary outcomes included evaluation of adenoma miss rate (AMR) and visibility score. Results: A total of 780 patients were randomized, 700 of whom were included in the final analysis. The ADR was 69.6% and 63.2% in the LCI and WLI groups, respectively, with no significant difference. However, LCI improved the average ADR in low-detectors compared with high-detectors (76.0% vs 55.1%; P < .001). Total AMR was 20.6% in the LCI group, which was significantly lower than that in the WLI group (31.1%) (P < .001). AMR in the LCI group was significantly lower, especially for diminutive adenomas (23.4% vs 35.1%; P < .001) and nonpolypoid lesions (25.6% vs 37.9%; P < .001) compared with the WLI group. Conclusion: Although both methods provided a similar ADR, LCI had a lower AMR than WLI. LCI could benefit endoscopists with lower ADR, an observation that warrants additional study. (UMIN Clinical Trials Registry, Number: UMIN000026359).

    DOI: 10.1016/j.cgh.2021.04.004

    Web of Science

    Scopus

    PubMed

  58. Novel ultrathin double-balloon endoscopy for the diagnosis of small-bowel diseases: a multicenter nonrandomized study.

    Nakamura M, Yano T, Esaki M, Oka S, Mitsui K, Hirai F, Kawasaki K, Fujishiro M, Torisu T, Tanaka S, Iwakiri K, Kishi M, Matsumoto T, Yamamoto H

    Endoscopy   Vol. 53 ( 8 ) page: 802 - 814   2021.8

     More details

    Language:English   Publisher:Endoscopy  

    Background This study aimed to compare the markers of potential pancreatic injury during antegrade double-balloon endoscopy (DBE) using the newly developed ultrathin EN-580XP system and the conventional EN-580T system. Methods Patients who were scheduled for antegrade DBE during daily clinical practice were enrolled. Clinical background, adverse events, and laboratory data of patients were compared between those who underwent endoscopy using the EN-580XP system and those in whom the EN-580T system was used. The primary end points were pancreatic hyperamylasemia and hyperlipasemia after DBE. Results A total of 295 cases were registered. Pancreatic hyperamylasemia occurred in 2 of 92 patients (2.2%) in the EN-580XP group and in 28 of 147 patients (19.1%) in the EN-580T diagnosis group (P <0.001). Hyperlipasemia was significantly different between the two groups (1.1% [EN-580XP] vs. 13.6% [EN-580T diagnosis]; P <0.001). Acute pancreatitis occurred in four patients (7.1%) in the EN-580T therapy group.Multiple logistic regression analyses revealed that the endoscope type EN-580T was significantly associated with pancreatic hyperamylasemia (adjusted odds ratio [OR] 8.63, 95% confidence interval [CI] 1.97-37.70; P <0.01) and hyperlipasemia (adjusted OR 13.10, 95%CI 1.70-100.70; P =0.01). Conclusions The EN-580XP system seemed less harmful to the pancreas during antegrade DBE.

    DOI: 10.1055/a-1243-0226

    Web of Science

    Scopus

    PubMed

  59. Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study

    Otsuka Hiroyuki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawade Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Iliroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page: 419 - 430   2021.8

     More details

    Language:Japanese   Publisher:Nagoya Journal of Medical Science  

    Patency capsule (PC) can evaluate the patency of gastrointestinal (GI) tract. We hypothesized preceding patient selection using PC would improve the successful rate of colon capsule endoscopy (CCE). Therefore, a prospective single-arm study using PC followed by CCE was conducted with a control group of CCE alone. Patients with suspected or known GI stenosis scheduled for CCE were enrolled. CCE was performed only when the PC was excreted out of the body within 33 hours of ingestion. Primary endpoint was the rate of observation of the entire GI tract within the duration of examination. The secondary endpoints were complications and CCE findings. Twenty-three patients (17 men) were enrolled. The mean age was 50.5±19.8 years. Suspected stenotic sites were 8, 5, and 10 in the small, large, and small and large bowel, respectively. Sixteen, 12, and 10 patients had abdominal pain, active inflammatory bowel disease, and history of surgery for suspected stenosis, respectively. Patency of GI tract was confirmed in 96% (22/23) of the patients by administered PC. Of the 22 patients who underwent CCE, the entire GI tract was observed in 86% (19/22). No complications were observed. The median transit times in the small bowel and colon were 99 (21–682) and 160 (5–328) minutes, respectively. CCE findings revealed ulcers, erosions, and diverticula in 5, 9, and 4 patients, respectively. In conclusion, CCE with PC might be a safer and useful modality to observe the large colon for patients with suspected GI stenosis.

    DOI: 10.18999/nagjms.83.3.419

    Web of Science

    Scopus

    PubMed

  60. Epstein-Barr Virus Positive B-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract

    Ishikawa Eri, Satou Akira, Nakamura Masanao, Nakamura Shigeo, Fujishiro Mitsuhiro

    CANCERS   Vol. 13 ( 15 )   2021.8

     More details

    Language:Japanese   Publisher:Cancers  

    Epstein-Barr virus positive B-cell lymphoproliferative disorder (EBV+ B-LPD) encompasses a broad clinicopathological spectrum and distinct clinical behavior that relatively favors the gastrointestinal (GI) tract. In this review, we provide an update on the clinicopathological features and biological behavior of EBV-positive mucocutaneous ulcer (EBVMCU) and primary EBV+ diffuse large B-cell lymphoma (DLBCL) of the GI tract. EBVMCU is a newly recognized entity but well known as an indolent and self-limited EBV+ B-LPD occurring in various immunodeficiencies. In contrast, EBV+ DLBCL constitutes the largest group of EBV+ B-LPDs and is regarded as an aggressive neoplasm. These two distinct diseases have historically been distinguished in the reappraisal of age-related EBV-associated B-LPDs but are challenging in routine practice regarding their differential diagnostic and therapeutic approaches. An increasing number of reports indicate that they are epidemiologically prevalent beyond western and eastern countries, but their comprehensive analysis is still limited. We also describe the PD-L1 positivity of tumorous large cells and non-malignant immune cells, which is relevant for the prognostic delineation among patients with primary DLBCL of the GI tract with and without EBV on tumor cells.

    DOI: 10.3390/cancers13153815

    Web of Science

    Scopus

    PubMed

  61. Difference of efficacy for small bowel lesion in Crohn

    Sawada T., Nakamura M., Yamamura T., Maeda K., Ishikawa E., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 36   page: 116 - 116   2021.8

     More details

    Language:Japanese  

    Web of Science

  62. Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's disease

    Nishikawa Takahiro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 36 ( 7 ) page: 1851 - 1858   2021.7

     More details

    Language:Japanese   Publisher:Journal of Gastroenterology and Hepatology (Australia)  

    Background and Aim: Endoscopic evaluation of disease activity, including mucosal healing, is poorly established in Crohn's disease. We previously reported that patients with a Lewis score (LS) on capsule endoscopy < 270 had a lower risk of exacerbation without additional treatment. This study investigated prognostic predictors in patients undergoing capsule endoscopy and determined the optimal LS cut-off value. Methods: In a retrospective single-center study, 102 patients with Crohn's disease who underwent capsule endoscopy were reviewed. We reviewed the clinical course and the patients' characteristics, Crohn's Disease Activity Index, laboratory findings, LS, and Prognostic Nutritional Index (PNI) for factors potentially associated with Crohn's disease-related emergency hospitalization. Subsequently, we prospectively enrolled 66 patients with Crohn's disease and analyzed clinical outcomes according to these factors. Results: In the retrospective study, LS ≥ 270 and PNI < 45 were identified as independent predictors of Crohn's disease-related emergency hospitalization with hazard ratios of 9.48 and 3.01, respectively. Even in patients with LS ≥ 270, cumulative hospitalization rates decreased after intervention based on capsule endoscopy findings. The prospective study confirmed that patients with LS ≥ 270 or PNI < 45 had a significantly higher risk of Crohn's disease-related emergency hospitalization and that additional treatment reduced the risk of relapse. Conclusions: LS and PNI are the best available prognostic predictors in patients with Crohn's disease without gastrointestinal stenosis and can guide decisions on treatment escalation. Patients with LS ≥ 270 and PNI < 45 were at increased risk for exacerbation, and additional treatments should be considered for this group.

    DOI: 10.1111/jgh.15366

    Web of Science

    Scopus

    PubMed

  63. An initial trial of quantitative evaluation of autoimmune pancreatitis using shear wave elastography and shear wave dispersion in transabdominal ultrasound

    Suzuki Hirotaka, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro

    PANCREATOLOGY   Vol. 21 ( 4 ) page: 682 - 687   2021.6

     More details

    Language:Japanese   Publisher:Pancreatology  

    Background/Objectives: We aimed to examine therapeutic efficacy and prognosis prediction of autoimmune pancreatitis (AIP) using shear wave elastography (SWE) and shear wave dispersion (SWD) in transabdominal ultrasound (US). Methods: The subjects were 23 patients with diffuse type 1 AIP who underwent SWE and SWD, and 34 controls with a normal pancreas. Elasticity and dispersion were defined as the pancreatic elastic modulus (PEM) and dispersion slope, respectively. PEM and dispersion slope were compared between AIP and control cases, and the short-term therapeutic effect and long-term prognosis were examined. Results: PEM (30.9 vs. 6.6 kPa, P < 0.001) and dispersion slope (15.3 vs. 13.0 (m/sec)/kHz, P = 0.011) were significantly higher in AIP cases than in controls. Among the 17 AIP patients followed-up in two weeks after treatment, these parameters were 12.7 kPa and 10.5 (m/sec)/kHz with median decrease rate of 37.2% and 32.8%, respectively, which were significantly higher than the change in the size of pancreatic parenchyma (14.4%, P = 0.026). Fourteen of these subjects were followed up for >12 months, during which 2 had relapse; diabetes improved in 5 and worsened in 2; in 60% of cases, the pancreatic parenchyma was atrophied. The % change in PEM after two weeks was tended to be higher in non-atrophy cases. Conclusion: SWE and SWD measurement in US may be useful for quantitative assessment of AIP and evaluation of short-term treatment efficacy.

    DOI: 10.1016/j.pan.2021.02.014

    Web of Science

    Scopus

    PubMed

  64. An evaluation of resectability among endoscopic treatment methods for rectal neuroendocrine tumors < 10 mm

    Toriyama Kazuhiro, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Furukawa Kazuhiro, Ishikawa Takuya, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    ARAB JOURNAL OF GASTROENTEROLOGY   Vol. 22 ( 2 ) page: 104 - 110   2021.6

     More details

    Language:Japanese   Publisher:Arab Journal of Gastroenterology  

    Background and Study Aims: With respect to rectal neuroendocrine tumor (NET) resection, it remains unclear which of the following methods is the most effective: conventional endoscopic mucosal resection (cEMR), EMR using a fitted cap (EMR-C), EMR with a ligation band device (EMR-L), or endoscopic submucosal dissection (ESD). Thus, in this study, we aim to retrospectively evaluate the most effective endoscopic resection for rectal NETs < 10 mm. Patients and methods: In total, 61 consecutive patients with primary rectal NETs < 10 mm in diameter were included in this study; they were then divided into three groups: those with cEMR; those with modified EMR (mEMR) involving EMR-C and EMR-L; and those with ESD. The primary endpoint was to evaluate the difference in the complete en bloc resection rate. The secondary endpoint was to investigate differences in procedure time and complications. Results: Among the three groups, a significant difference was found in procedure time (cEMR vs ESD, P < .01; mEMR vs ESD, P < .01), en bloc resection rate (cEMR vs mEMR, P = .015), tumor size (mEMR vs ESD, P < .01), percentage of tumor diameter ≥ 5 mm (mEMR vs ESD, P < .01), and complete en bloc resection rate (cEMR vs mEMR, P = .014). Meanwhile, no significant difference was noted in terms of complication rate among the three groups. Conclusion: The mEMR was the most suitable resection method for rectal NETs < 10 mm with respect to the risks and benefits from procedure-related factors, such as complete en bloc resection rate, procedure time, and complication rate.

    DOI: 10.1016/j.ajg.2021.05.007

    Web of Science

    Scopus

    PubMed

  65. Endoscopic removal of a fish bone piercing the bile duct after pancreaticoduodenectomy

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nakamura Masanao, Yamada Suguru, Hayashi Masamichi, Fujishiro Mitsuhiro

    ENDOSCOPY   Vol. 53 ( 05 ) page: E164 - E165   2021.5

     More details

    Language:Japanese   Publisher:Endoscopy  

    DOI: 10.1055/a-1224-3724

    Web of Science

    Scopus

    PubMed

  66. Effects of endoscopy-related procedure time on musculoskeletal disorders in Japanese endoscopists: a cross-sectional study

    Matsuzaki Ippei, Ebara Takeshi, Tsunemi Mafu, Hatta Yoshifumi, Yamamoto Kojiro, Baba Akemi, Hattori Masashi, Nakamura Masanao, Fujishiro Mitsuhiro

    ENDOSCOPY INTERNATIONAL OPEN   Vol. 09 ( 05 ) page: E674 - E683   2021.5

     More details

  67. Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 2021   page: 8875564   2021.4

     More details

    Language:Japanese   Publisher:Canadian Journal of Gastroenterology and Hepatology  

    Introduction. Ischemic enteritis (IE) is a relatively rare small bowel disease that is diagnosed via double-balloon endoscopy (DBE), although the lack of established diagnostic criteria can make it difficult to confirm the diagnosis. This study aimed to describe the clinical characteristics, endoscopic imaging features, and treatments for IE at our center. Patients and Methods. We retrospectively searched the DBE database (1,521 patients) at Nagoya University Hospital for patients with IE and collected data regarding endoscopic findings, clinical background, and histological findings. The cases were categorized according to whether they involved transient or stenotic IE. Results. The DBE database included 24 patients (14 men) with IE. Transient IE was identified in 9 patients, and stenotic IE was identified in 15. Half of the patients had a history of cerebrovascular and cardiovascular disease. A granular structure at the ulcer base was the most frequently observed DBE finding at the stenotic site. Enterography using the contrast medium revealed that transient IE had a similar stenotic lesion length, relative to stenotic IE, although stenotic IE had a significantly higher stenosis ratio (81% vs. 63%, P=0.033). Small bowel enteroclysis revealed the "lead pipe"sign (11 patients), thumbprinting (3 patients), and the serrated lumen sign (1 patient). Only 1 patient with stenotic IE experienced recurrence after conservative treatment. Conclusion. During DBE, IE was characterized by cannular stenosis with extended and variable ulceration types, which spread over the edge of the stenosis, and a granular appearance at the ulcer base. These findings may help guide the diagnosis of IE.

    DOI: 10.1155/2021/8875564

    Web of Science

    Scopus

    PubMed

  68. Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer

    Yoshikawa Masakatsu, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kinoshita Fumie, Kawashima Hiroki, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 7409   2021.4

     More details

    Language:Japanese   Publisher:Scientific Reports  

    Shear wave elastography (SWE) is a technique to non-invasively and quantitatively evaluate tissue stiffness. We aimed to investigate whether we can differentiate pancreatic cancer (PC) from normal pancreatic parenchyma (NPP) by SWE using transabdominal ultrasound. We investigated a total of 106 patients (84 with NPP and 22 with PC) whose pancreatic elastic modulus was measured by two-dimensional SWE (2D-SWE). Intra-rater reliability in this study was examined, and three measurements were sufficiently reliable. There were no differences between the two groups in factors that could affect SWE measurements. The median value of the elastic modulus was 5.70 kPa in the PC patients and 5.66 kPa in the NPP group, which was not significantly different (P = 0.785). On the contrary, the range was 8.64 kPa and 4.72 kPa, with a significantly greater range in the PC patients (P = 0.001). In conclusion, the median elastic modulus measured by 2D-SWE was not significantly different between PC and NPP, and evaluating the obtained elastic modulus itself is not useful in differentiation. However, the variability was significantly greater in PC than in NPP. Evaluating the range of elasticities will provide additional information in SWE, which may be useful in the diagnosis of PC.

    DOI: 10.1038/s41598-021-86979-5

    Web of Science

    Scopus

    PubMed

  69. The relationship between oral-origin bacteria in the fecal microbiome and albumin-bilirubin grade in patients with hepatitis C

    Yamamoto Kenta, Honda Takashi, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Nakamura Masanao, Miyahara Ryoji, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 36 ( 3 ) page: 790 - 799   2021.3

     More details

    Language:Japanese   Publisher:Journal of Gastroenterology and Hepatology (Australia)  

    Background: Bacteria of oral origin (BO) in the gut are associated with prognosis in patients with cirrhosis. The Greengenes database (gg_13_8) is widely used in microbiome analysis, but the expanded Human Oral Microbiome Database (eHOMD), a specialized database for BO, can add more detailed information. We used each database to evaluate the relationship between the albumin–bilirubin grade (ALBI) and the microbiome in patients with hepatitis C. Methods: Eighty patients were classified into the low ALBI group (LA; n = 34) or high ALBI group (HA; n = 46). Isolated DNA from stool was amplified to target the V3–4 regions of 16S rRNA. The microbiomes of the two groups were compared using gg_13_8 or eHOMD. We evaluated the associations between microbiomes and prognoses using Cox proportional hazards models. Results: At the genus level, the two groups differed significantly regarding 6 (gg_13_8) and 7 (eHOMD) types of bacteria. All types except Akkermansia are classified as BO. Both databases showed an increase in Streptococcus and Veillonella. eHOMD showed a decrease in Fusobacterium and an increase in Fretibacterium; both produce various types of short-chain fatty acids. At the species level, the two groups demonstrated significant differences in 2 (gg_13_8) and 6 (eHOMD) bacterial types. Selenomonas noxia and Streptococcus salivarius were related to poor prognosis in univariate analysis. Conclusion: The HA group demonstrated increased BO, most of which produce lactic acid or acetic acid. The correlation between the microbiome and metabolism might be related to prognosis. eHOMD was a useful database for analyzing BO.

    DOI: 10.1111/jgh.15206

    Web of Science

    Scopus

    PubMed

  70. Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   Vol. 21 ( 1 ) page: 75   2021.2

     More details

    Language:Japanese   Publisher:BMC Gastroenterology  

    Background: Crohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well as the small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables observation of the whole GI tract, but its diagnostic yield for CD lesions in the whole GI tract remains unknown. Aim: To elucidate the diagnostic yield of PCCE-2 in patients with CD. Methods: Patients with CD who underwent PCCE-2 and double-balloon endoscopy (DBE) using oral and anal approaches were evaluated for CD lesions in the whole GI tract. We divided the small bowel into three segments (jejunum, ileum, and terminal ileum), and the large bowel into four segments (right colon, transverse colon, left colon, rectum). Detection of ulcer scars, erosion, ulcers, bamboo joint-like appearance, and notch-like appearance was assessed in each segment. The diagnostic yield of PCCE-2 was analyzed based on the DBE results as the gold standard. Results: Of the total 124 segments, the sensitivities of PCCE-2 for ulcer scars, erosion, and ulcers were 83.3%, 93.8%, and 88.5%, respectively, and the specificities were 76.0%, 78.3%, and 81.6%, respectively. For the 60 small bowel segments, the sensitivities were 84.2%, 95.5%, and 90.0%, respectively, and the specificities were 63.4%, 86.8%, and 87.5%, respectively. For the 64 large bowel segments, the sensitivities were 80.0%, 90.0%, and 83.3%, respectively, and the specificities were 84.7%, 72.2%, and 77.6%, respectively. Conclusion: PCCE-2 provides a high diagnostic yield for lesions in the whole GI tract of patients with CD. Thus, we recommend its use as a pan-enteric tool in clinical settings.

    DOI: 10.1186/s12876-021-01657-0

    Web of Science

    Scopus

    PubMed

  71. Ustekinumab is effective against small bowel lesions in Crohn's disease: two case reports

    Murate Kentaro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    CLINICAL JOURNAL OF GASTROENTEROLOGY   Vol. 14 ( 1 ) page: 129 - 135   2021.2

     More details

    Language:Japanese   Publisher:Clinical Journal of Gastroenterology  

    We encountered two patients with Crohn’s disease (CD) for whom induction of ustekinumab was effective for the management of small intestinal lesions with stenosis. The first symptomatic CD case was a 40-year-old female with longitudinal ulcers in the small bowel found at double-balloon endoscopy. She was in a biologic-naïve condition. Her symptoms improved immediately after ustekinumab induction. We confirmed the condition of intestinal mucosa by double-balloon endoscopy. Deep ulcers remained open at 24 weeks and were scarred at 72 weeks. The second case was a 50-year-old male who failed to respond to treatment with anti-TNFα agents. The lumen was narrow caused by circumferential ulcer, and an endoscope could not pass the site before induction. The circumferential ulcer had been healed by ustekinumab induction, and an endoscope passed through at 72 weeks. These two cases support the therapeutic efficacy of ustekinumab in alleviating small bowel lesions in CD patients.

    DOI: 10.1007/s12328-020-01242-0

    Web of Science

    Scopus

    PubMed

  72. A Prospective Study Evaluating the Clinical Utility of the Tag-Less Patency Capsule with Extended Time for Confirming Functional Patency

    Watanabe Kenji, Ohmiya Naoki, Nakamura Masanao, Fujiwara Yasuhiro

    DIGESTION   Vol. 102 ( 2 ) page: 180 - 187   2021.2

     More details

    Language:Japanese   Publisher:Digestion  

    Background: Patency confirmation is useful for avoiding the retention of capsule endoscopy (CE). We first evaluated the clinical utility of the tag-less PillCamTM Patency Capsule (PPC) for up to 72 h after ingestion prospectively. Methods: Excretion of an intact capsule or intact body within 72 h, or positive PPC image in the colon or negative PPC image by abdominal X-ray at 30 h was defined as confirmed functional patency. In patients with unconfirmed functional patency, balloon-assisted enteroscopy was performed to evaluate the reason. Results: Functional patency was confirmed in 44 of 57 patients. Patency was confirmed in 38 patients (66.7%) at 30 h. In 6 of 19 patients (31.6%) in whom patency was not confirmed at 30 h, patency was confirmed within 72 h and no capsule retention (CR) occurred. The rate of pan-enteroscopy did not differ between patients whose patency was confirmed at 30 h and those whose patency was confirmed within 72 h. Excretion time of the PPC significantly correlated with that of the capsule (r = 0.650). Severe adhesions (>5 cm) interfered with PPC passage in 2 patients, despite the absence of critical stricture. The rate of no CR in patients with functional patency confirmed by prior PPC was 97.7%. Misjudgment of the location of the PPC is a risk for CR. Conclusions: Extending the time to confirm functional patency to 72 h may be acceptable and increase the possibility to perform CE safely in whom CE can perform intrinsically. University Hospital Medical Information Network registration No: 000002564.

    DOI: 10.1159/000503027

    Web of Science

    Scopus

    PubMed

  73. Systematic review and meta-analysis of the diagnostic and therapeutic yield of small bowel endoscopy in patients with overt small bowel bleeding

    Uchida Genta, Nakamura Masanao, Yamamura Takeshi, Furukawa Kazuhiro, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   Vol. 33 ( 1 ) page: 66 - 82   2021.1

     More details

    Language:Japanese   Publisher:Digestive Endoscopy  

    Background: Small bowel endoscopy, including small bowel capsule endoscopy (SBCE) and balloon-assisted endoscopy (BAE), is useful for small bowel bleeding (SBB) assessment. However, the specific management strategy for overt SBB is not well established. This meta-analysis aimed to evaluate the pooled diagnostic yields (DYs) and therapeutic yields (TYs) of small bowel endoscopy in overt SBB and to determine the optimal endoscopy timing. Methods: A comprehensive literature search was performed of studies examining the DY and/or TY of small bowel endoscopy in overt SBB. Data on the DY, TY, and timing of small bowel endoscopy were extracted, pooled, and analyzed. The pooled DY and TY of small bowel endoscopy for patients with overt SBB were calculated. Meta-regression and subgroup analysis were performed. Results: Twenty-two studies were included. The pooled DY was 65.2% and 74.0% for SBCE and BAE, respectively. The pooled TY of SBCE and BAE was 55.9% and 35.8%, respectively. A meta-regression model showed that the timing of endoscopy was significantly associated with the DY of BAE and the TY of SBCE and BAE. Conclusions: Small bowel capsule endoscopy and BAE would be useful diagnostic and therapeutic modalities in overt SBB. According to the subgroup analysis, in which the TY seemed to be higher within 2 days after bleeding for SBCE and BAE, the optimal timing of endoscopy would be within 2 days.

    DOI: 10.1111/den.13669

    Web of Science

    Scopus

    PubMed

  74. Gastrointestinal tract metastasis of lung cancer: The PD-L1 expression and correlated clinicopathological variables

    Ishikawa Eri, Nakaguro Masato, Nakamura Masanao, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Maeda Keiko, Furukawa Kazuhiro, Shimoyama Yoshie, Kawashima Hiroki, Fujishiro Mitsuhiro

    PATHOLOGY INTERNATIONAL   Vol. 71 ( 1 ) page: 33 - 41   2021.1

     More details

    Language:Japanese   Publisher:Pathology International  

    The gastrointestinal tract is a rare site for metastatic lung cancer. Programmed cell death-ligand 1 (PD-L1) expression in lung cancer is a biomarker for the response to anti-PD-1/PD-L1 therapy. We investigated clinicopathological features and PD-L1 expression in 25 gastrointestinal metastatic tumors from the lung and primary adenocarcinoma of the small bowel. The small bowel was the most common site (16/25; 64%) of gastrointestinal tract lung cancer metastasis. A total of 19 (76%) of the gastrointestinal metastasis showed PD-L1 expression in ≥5% of tumor cells, with 14 (56%) showing high expression levels (≥50%). In contrast, 21 (84%) expressed PD-L1 in ≥5% immune cells, including 4 (16%) showing a high expression levels (≥50%). The PD-L1 expression on tumor cells and immune cells in primary lung cancer and corresponding gastrointestinal metastasis was concordant in 13 (68%) and 11 (58%) of the 19 paired cases, respectively. Small-bowel metastasis of lung cancer was characterized by a higher incidence of perforation (31% vs. 0%), ulcerated mass (83% vs. 60%), and neoplastic PD-L1 expression (75% vs. 0%) compared to primary small-bowel adenocarcinoma. Gastrointestinal metastasis from lung cancer might be a potential target for immune checkpoint inhibitor therapy, given its high expression of PD-L1.

    DOI: 10.1111/pin.13048

    Web of Science

    Scopus

    PubMed

  75. Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study

    OHNO Eizaburo, HIROOKA Yoshiki, KAWASHIMA Hiroki, ISHIKAWA Takuya, TANAKA Hiroyuki, SAKAI Daisuke, ISHIZU Yoji, KUZUYA Teiji, NAKAMURA Masanao, HONDA Takashi

    Choonpa Igaku   Vol. 48 ( 1 ) page: 35 - 44   2021

     More details

    Language:Japanese   Publisher:The Japan Society of Ultrasonics in Medicine  

    <p><b>Purpose</b>: To assess the feasibility and the clinical usefulness of a newly developed endoscopic ultrasonography (EUS) shearwave elastography technique (EUS shear-wave measurement: EUS-SWM) in the diagnosis and treatment of autoimmune pancreatitis (AIP). <b>Methods</b>: Tissue elasticity was measured in the pancreas in 160 patients. The success rate of EUS-SWMs, the velocity of the shear wave (Vs, m/s), and the reliability index of the Vs measurement (VsN) were evaluated, and the elasticity (median Vs) was compared between AIP patients (<I>n</I>=14) and normal controls. <b>Results</b>: A total of 3837 EUS-SWMs were performed without adverse events. Overall, 97.6% (3,743/3,837) were successful. The median VsN was 74%. The median Vs values of the pancreas were as follows: 2.22 m/s in the pancreatic head (push position), 2.36 m/s in the head (pull position), 1.99 m/s in the body, and 2.25 m/s in the tail. The median Vs of the AIP group (2.57 m/s) was significantly higher than that of the normal controls (1.89 m/s) (<I>P</I>=0.0185). The mean Vs significantly decreased from 3.32 m/s to 2.46 m/s after steroid therapy (<I>n</I>=6) (<I>P</I>=0.0234). <b>Conclusion</b>: EUS-SWM is feasible and generates credible results. EUS-SWM was a useful method for assessment of the effect of steroid therapy in AIP patients.</p>

    DOI: 10.3179/jjmu.jjmu.k.22

    CiNii Research

  76. A CASE OF A SUBTYPE OF EOSINOPHILIC ESOPHAGITIS WITH MINOR EPITHELIAL CHANGES AND THICKENED MUSCLE LAYER

    MUROI Koichi, FURUKAWA Kazuhiro, SUZUKI Tomohiko, HIROSE Takashi, ITO Nobuhito, FURUNE Satoshi, KAKUSHIMA Naomi, NAKAMURA Masanao, OOBAYASHI Tomohiko, FUJISHIRO Mitsuhiro

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 63 ( 3 ) page: 279 - 286   2021

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>Eosinophilic esophagitis (EoE) is a chronic inflammatory disease, clinically characterized by symptoms related to esophageal dysfunction and histologically characterized by eosinophil-predominant inflammation. In rare cases, there have been reports of subepithelial eosinophilic esophagitis or eosinophilic esophageal myositis, both of which are difficult to diagnose because the eosinophils are deeply infiltrated.</p><p>A 74-year-old male underwent esophagogastroduodenoscopy (EGD) to find the cause of dysphagia, but no abnormalities were observed. Although he started to take esomeprazole, his symptoms persisted. Six months later, he was hospitalized because of difficulty in oral feeding. EGD revealed mucosal cloudy edema around the middle and lower esophagus and a ring-shaped stenosis, which resulted in obstruction of passage. We suspected EoE by various examinations, but biopsies showed no eosinophil infiltration in the esophageal epithelium. Endoscopic ultrasound (EUS) showed thickening of the esophageal wall including the muscle layer. We diagnosed EoE with deep infiltration of eosinophils by repeated biopsies. We herein report a case of an EoE subtype in which severe obstruction of the esophagus occurred in six months and evaluation of the esophageal wall by EUS was useful for diagnosis.</p>

    DOI: 10.11280/gee.63.279

    Scopus

    CiNii Research

  77. DIAGNOSIS AND TREATMENT OF HAMARTOMATOUS POLYPOSIS SYNDROMES

    OHMIYA Naoki, NAKAMURA Masanao, SHIBATA Tomoyuki

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 63 ( 7 ) page: 1323 - 1335   2021

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>The hamartomatous polyposis syndromes are a group of inherited disorders that include Peutz-Jeghers syndrome (PJS), juvenile polyposis syndrome, Cowden syndrome, and tuberous sclerosis complex (TSC). PJS, Cowden syndrome, and TSC are characterized by phenotypic manifestations, which may be a clue to their diagnosis. The most frequent complications of PJS are intussusception and chronic anemia. Earlier entire small bowel examination with capsule endoscopy and balloon-assisted enteroscopy enabling accurate diagnosis and subsequent endoscopic polyp removal obviates the need for unnecessary multiple surgeries. Patients with a hamartomatous polyposis syndrome are at an elevated risk for gastrointestinal and extragastrointestinal malignancies; therefore periodic surveillance is needed. Here, we describe the clinical features, diagnostics, and therapeutics of hamartomatous polyposis syndromes.</p>

    DOI: 10.11280/gee.63.1323

    Scopus

    CiNii Research

  78. Survey of chemotherapy-induced nausea and vomiting in patients with urothelial carcinoma

    Yoshimi A., Shiroma Y., Iwata M., Nakamura M., Torii-Goto A., Hida H., Tanaka N., Miyazaki M., Yamada K., Noda Y.

    Molecular and Clinical Oncology   Vol. 15 ( 4 )   2021

     More details

    Language:Japanese   Publisher:Molecular and Clinical Oncology  

    Chemotherapy-induced nausea and vomiting (CINV) can cause anorexia, weight loss and deterioration of patient quality of life. It is one of the most unpleasant adverse effects of chemotherapy treatment regimens. For the optimal treatment of gastrointestinal symptoms during urothelial carcinoma chemotherapy, the present study investigated the association between gastrointestinal symptoms and therapeutic effects of gemcitabine plus platinum [cisplatin (GC) or carboplatin (GCa)] therapies. The incidence and frequency of nausea/vomiting with GC split therapy (gemcitabine, 1,000 mg/m2 on days 1 and 8; split-dose cisplatin, 35 mg/m2 on days 1 and 8; 21-day schedule) and GCa therapy [gemcitabine, 750-1,000 mg/m2 on days 1, 8 and 15; carboplatin, area under the blood concentration-time curve=5 mg min/ml (Calvert formula) on day 2; 28-day schedule] were lower compared with those of GC therapy (gemcitabine, 1,000 mg/m2 on days 1, 8 and 15; single-dose cisplatin 70 mg/m2 on day 2; 28-day schedule). However, no differences in therapeutic outcomes were observed among therapies. GCa therapy, regardless of renal function, and GC split therapy demonstrated significant increases compared with GC therapy in alleviating gastrointestinal symptoms associated with cancer chemotherapy in patients with urothelial carcinoma. Overall, these results suggested that split-dose cisplatin administration or the use of carboplatin instead of cisplatin may be useful in patients who experience CINV without compromising treatment effectiveness.

    DOI: 10.3892/mco.2021.2384

    Scopus

  79. SYSTEMATIC REVIEW AND META-ANALYSIS OF THE DIAGNOSTIC AND THERAPEUTIC YIELD OF SMALL BOWEL ENDOSCOPY IN PATIENTS WITH OVERT SMALL BOWEL BLEEDING

    UCHIDA Genta, NAKAMURA Masanao, YAMAMURA Takeshi, FURUKAWA Kazuhiro, KAWASHIMA Hiroki, HONDA Takashi, ISHIGAMI Masatoshi, FUJISHIRO Mitsuhiro

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 63 ( 9 ) page: 1649 - 1665   2021

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>Background: Small bowel endoscopy, including small bowel capsule endoscopy (SBCE) and balloon-assisted endoscopy (BAE), is useful for small bowel bleeding (SBB) assessment. However, the specific management strategy for overt SBB is not well established. This meta-analysis aimed to evaluate the pooled diagnostic yields (DYs) and therapeutic yields (TYs) of small bowel endoscopy in overt SBB and to determine the optimal endoscopy timing.</p><p>Methods: A comprehensive literature search was performed of studies examining the DY and/or TY of small bowel endoscopy in overt SBB. Data on the DY, TY, and timing of small bowel endoscopy were extracted, pooled, and analyzed. The pooled DY and TY of small bowel endoscopy for patients with overt SBB were calculated. Meta-regression and subgroup analysis were performed.</p><p>Results: Twenty-two studies were included. The pooled DY was 65.2% and 74.0% for SBCE and BAE, respectively. The pooled TY of SBCE and BAE was 55.9% and 35.8%, respectively. A meta-regression model showed that the timing of endoscopy was significantly associated with the DY of BAE and the TY of SBCE and BAE.</p><p>Conclusions: Small bowel capsule endoscopy and BAE would be useful diagnostic and therapeutic modalities in overt SBB. According to the subgroup analysis, in which the TY seemed to be higher within 2 days after bleeding for SBCE and BAE, the optimal timing of endoscopy would be within 2 days.</p>

    DOI: 10.11280/gee.63.1649

    Scopus

    CiNii Research

  80. TAG-LESS PATENCY CAPSULE FOR SUSPECTED SMALL BOWEL STENOSIS: NATIONWIDE MULTICENTER PROSPECTIVE STUDY IN JAPAN

    NAKAMURA Masanao, WATANABE Kenji, OHMIYA Naoki, HIRAI Fumihito, OMORI Teppei, TOKUHARA Daisuke, NAKAJI Konosuke, NOUDA Sadaharu, ESAKI Motohiro, SAMESHIMA Yukinori, GOTO Hidemi, TERANO Akira, TAJIRI Hisao, MATSUI Toshiyuki, J-POP study group

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 63 ( 10 ) page: 2242 - 2252   2021

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>Study aims: The PillCam patency capsule (PPC) is an Agile tag-less patency capsule used to evaluate gastrointestinal (GI) patency. We determined the appropriate use of PPC to preclude subsequent small bowel capsule endoscopy (SBCE) retention.</p><p>Methods: This prospective multicenter study consecutively enrolled patients indicated for SBCE with suspected or established small bowel stenosis. Excretion of an intact PPC or its radiologic visualization in the large bowel was considered GI patency. Primary and secondary study endpoints were SBCE retention rates in patients with confirmed patency and identification of factors associated with patency and SBCE retention, respectively.</p><p>Results: Of 1096 patients enrolled in the study, patency was confirmed in 976 (89.1%). PPC excretion occurred in 579 patients. Of the remaining 517 patients, patency was confirmed using imaging modalities in 401 (77.5%). SBCE retention occurred in five (0.51%) of 963 patients who underwent SBCE: 1.0% in established Crohnʼs disease (CD) patients, 0% in suspected CD, 0% in tumors, and 1.6% in patients with obscure GI bleeding, for which PPC localization had been radiographically misinterpreted. The non-confirmation of patency was associated with established CD, stenosis identified using imaging modalities, abdominal fullness, serum albumin levels <4.0g/dL, and previous small bowel obstruction (adjusted odds ratios: 4.21, 2.60, 2.47, 2.12, and 2.00; 95% confidence intervals: 2.62-6.78, 1.62-4.17, 1.43-4.27, 1.32-3.40, and 1.15-3.47, respectively).</p><p>Conclusions: The PillCam<sup>TM</sup> patency capsule helped preclude SBCE retention in most patients, but its accurate localization was essential for cases without excretion (Study registered the University Hospital Medical Information Network, #UMIN000010513).</p>

    DOI: 10.11280/gee.63.2242

    Scopus

    CiNii Research

  81. Impact of SARS-CoV-2 Pandemic on Colorectal Cancer Screening Delay:Effect on Stage Shift and Increased Mortality<sup> 1)</sup>.

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 63 ( 12 ) page: 2525 - 2525   2021

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    DOI: 10.11280/gee.63.2525

    CiNii Research

  82. 内視鏡的小腸カプセル内視鏡 (CE) 留置術の安全性・有効性に関する全国多施設共同研究

    大宮 直木, 岡 志郎, 中山 佳子, 岩間 達, 中村 正直, 田中 信治

    日本小腸学会学術集会プログラム・抄録集   Vol. 5 ( 0 ) page: 48 - 48   2021

     More details

    Language:Japanese   Publisher:日本小腸学会  

    <p>【目的】今回、小児・成人例におけるCE挿入補助器具の使用実態について調査し、その有効性および安全性を遡及的に多施設共同で検討した。【方法】REDCap<sup>®</sup>を用いて、1.CE検査数、2.CE内服不可または不可と予測された件数、3.内服不可(予測含む)および挿入補助具使用の内訳:性別、年齢、身長、体重、検査契機、病名、既往歴、CE嚥下可能・不可・不可(予測)、嚥下不可(予測含む)であった理由、補助具種類、カプセル留置部位、有害事象、全小腸観察の有無をオンライン登録した。【結果】全国20施設(消化器内科11施設、小児科9施設)で施行されたCE 10,156件のうち、内視鏡的留置術を行ったCEは546件(5.4%)。有害事象は治療不要な出血、粘膜損傷等の軽微なもののみで163件(29.9%)。十二指腸または空腸へのCE留置成功率は16歳未満で92.0% (335/364)、16歳以上で92.3% (168/182) と有意差なかったが、全小腸観察率は16歳未満で91.7%、16歳以上で76.2%と有意差あり(P<0.0001)。16歳以上でCE嚥下不可能の全小腸観察率は87.3%、胃内停滞例の全小腸観察率は64.2%と有意に低下していた(P=0.0010)。CEの食道停滞例は28例(5.1%)で、28.6%が心疾患、胃停滞例は69例(12.6%)で、糖尿病(15.7%)、腹部術後(15.7%) 等の基礎疾患。16歳未満のCE嚥下不可能(予測も含む)を推測するカットオフ値は身長132cm、体重24.8kg、年齢9歳2ヶ月。【結語】小児・成人に対する内視鏡的経口CE留置術は安全かつ有用な手技であるが、食道・胃停滞例では蠕動を促す他の処置も必要である。</p>

    DOI: 10.32264/shocho.5.0_48

    CiNii Research

  83. 炎症性腸疾患に対するインフラマソーム標的治療法の開発

    池上 脩二, 前田 啓子, 中村 正直

    日本小腸学会学術集会プログラム・抄録集   Vol. 5 ( 0 ) page: 51 - 51   2021

     More details

    Language:Japanese   Publisher:日本小腸学会  

    <p>【背景と目的】近年, 炎症性腸疾患(IBD)患者の急増とともに, 治療抵抗性の難治例が増加し, 病態に応じた新規治療薬開発が課題となっている.その病態には粘膜免疫の破綻,腸内細菌の関与とともに,両者を制御するインフラマソーム経路の重要性が認識されている.私達は, 治療抵抗性のIBD患者の血液, 腸管組織においてインフラマソーム関連サイトカインであるインターロイキン18(IL-18)の発現の上昇を見出した.本研究の目的は, 難治性IBDへの治療応用を見据え, 抗ヒト活性型IL-18モノクローナル抗体を作成し, IBDモデルマウスを用いて腸炎抑制効果, 作用機序の解明を行うことである.【方法】ヒトIL-18プロ体をカスパーゼで切断し活性型IL-18を作製し,ヒト活性型IL-18に対するモノクローナル抗体を樹立した.構造解析,機能阻害アッセイを行い, 阻害効果を持つ抗体を選別した.DSS誘導性腸炎モデルマウスを作成し, 抗IL-18抗体の腹腔内投与を行い, 腸炎スコア, 体重減少率を評価した.病理学的評価, 炎症性サイトカインの発現, FITC-Dextranの透過量の測定, NGSによる腸内細菌叢の解析を行った.【結果】高い親和性でIL-18と結合し, IL-18が誘導するIFN-<i>γ</i>産生を強力に抑制する抗ヒト活性型IL-18抗体の作成に成功した.抗体投与により腸炎の改善を認め, IFN-<i>γ</i>, TNF-<i>α</i>の発現抑制, FITC-Dextranの透過量の低下, 腸炎により増加したEnterococcus属, Staphylococcus属の低下を認めた. 更に抗TNF-<i>α</i>抗体との併用ではより強力に腸炎を抑制した.【結論】抗IL-18抗体は, 炎症性サイトカインの分泌抑制に加え, 腸内細菌叢の制御,腸管上皮透過性亢進の改善を介して腸炎を改善させた. 既存治療薬との併用により腸炎抑制効果の増強が認められ,難治例への治療応用が期待される.</p>

    DOI: 10.32264/shocho.5.0_51

    CiNii Research

  84. A novel Lugol's iodine staining technique to visualize the upper margin of the surgical anal canal intraoperatively for Hirschsprung disease: a case series

    Yokota Kazuki, Amano Hizuru, Kudo Toyoki, Yamamura Takeshi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Nakamura Masanao, Fujishiro Mitsuhiro, Hinoki Akinari, Uchida Hiroo

    BMC SURGERY   Vol. 20 ( 1 ) page: 317   2020.12

     More details

    Language:Japanese   Publisher:BMC Surgery  

    Background: In cases of Hirschsprung disease, complete and reproducible resection of the aganglionic bowel is ideal to achieve good postoperative bowel function. Reliable identification of the upper margin of the surgical anal canal, which is the squamous-columnar junction, is necessary during transanal pull-through. Here, we describe a novel staining technique using Lugol’s iodine stain to visualize the upper margin of the surgical anal canal. Methods: Lugol’s iodine staining was performed in five patients with Hirschsprung disease treated using a single-stage laparoscopic transanal pull-through modified Swenson procedure. In two of these patients, endocytoscopic observation with ultra-high magnification was performed using methylene blue and crystal violet to mark the border of the squamous epithelium at 1 week before surgery. The alignment between the incisional line, which was revealed using Lugol’s iodine staining and endocytoscopic marking, was evaluated. Complications, including postoperative bowel dysfunction, were evaluated. Results: In all cases, Lugol’s iodine staining produced a well-demarcated line. The endocytoscopic marking of the upper margin of the surgical anal canal was aligned with the line revealed by Lugol’s iodine staining. There were no complications associated with the transanal pull-through procedure, including postoperative bowel dysfunction. Conclusions: Lugol’s iodine staining could be a safe and practical method to visualize the upper margin of the surgical anal canal intraoperatively. This finding may be useful for surgeons to make a consistent removal of the aganglionic bowel during surgery for Hirschsprung disease.

    DOI: 10.1186/s12893-020-00986-3

    Web of Science

    Scopus

    PubMed

  85. Glycoproteomic analysis identifies cryptdin-related sequence 1 as O-glycosylated protein modified with alpha 1,2-fucose in the small intestine

    Hashiguchi Hiroki, Tsukamoto Yohei, Ogawa Mitsutaka, Tashima Yuko, Takeuchi Hideyuki, Nakamura Masanao, Kawashima Hiroki, Fujishiro Mitsuhiro, Okajima Tetsuya

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 695   page: 108653   2020.11

     More details

    Language:Japanese   Publisher:Archives of Biochemistry and Biophysics  

    The modification of galactose with α1,2-fucose is involved in symbiosis with intestinal bacteria and elimination of pathogenic bacteria. It is postulated that α1,2-fucosylated mucin secreted from goblet cells is involved in defending an organism against infections, but the detailed molecular mechanisms are yet to be elucidated. It was previously reported that Paneth cells of the small intestine were positive for UEA-1 lectin staining. However, glycoproteins in Paneth cells carrying α1,2-fucose have not yet been identified. Glycoproteomic analysis of ileal lysates identified 3212 O-linked and 2962 N-linked glycopeptides. In particular, cryptdin-related sequence 1 (CRS1) expressed in Paneth cells was found to be α1,2-fucosylated. Unlike other antimicrobial α-defensin proteins, CRS1 contains unique Thr residues, which are modified with O-glycans, with 3HexNAc2Hex1Fuc1NeuAc being the main glycoform. Identification of α1,2-fucose on the O-glycans of CRS1 expressed in Paneth cells will pave the way for a mechanistic understanding of α1,2-fucose-dependent symbiosis with intestinal bacteria and elimination of pathogenic bacteria in the intestine.

    DOI: 10.1016/j.abb.2020.108653

    Web of Science

    Scopus

    PubMed

  86. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

    Niwa Yoshiki, Nakamura Masanao, Kawashima Hiroki, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 26 ( 42 ) page: 6669 - 6678   2020.11

     More details

    Language:Japanese   Publisher:World Journal of Gastroenterology  

    BACKGROUND Retrograde cholangiopancreatography using double-balloon endoscopic retrograde cholangiography (DBERC) is a valuable technique to treat biliary stone and jejunobiliary anastomotic stenosis in patients with altered gastrointestinal anatomy. The accurate selection of the route at the anastomosis branch is one of the most important factors in reaching the target in a timely manner. AIM To determine the accuracy of carbon dioxide insufflation enterography (CDE) at the branch for selecting the correct route during DBERC. METHODS We enrolled 52 consecutive patients scheduled for DBERC at our institution from June 2015 to November 2017. Route selection via two methods (visual observation and CDE) was performed in each patient. We determined the correct rate of route selection using CDE. RESULTS Thirty-three patients had a jejunojejunal anastomosis and 19 patients had a gastrojejunal anastomosis. The therapeutic target region was reached in 50 patients. The mean procedure times from the teeth to the target (total insertion time), from the teeth to the branch, and from the branch to the target, and the mean total examination time were 15.2, 5.0, 8.2, and 60.3 min, respectively. The rate of correct route selection using visual observation and CDE were 36/52 (69.2%) and 48/52 (92.3%), respectively (P = 0.002). The rate of correct route selection using CDE in patients with a jejunojejunal anastomosis was 29/33 (87.8%), and the rate in patients with a gastrojejunal anastomosis was 19/19 (100%). CONCLUSION CDE is helpful in selecting the route at the branch in the anastomosis for more timely access to the target in patients with altered gastrointestinal anatomy undergoing DBERC.

    DOI: 10.3748/wjg.v26.i42.6669

    Web of Science

    Scopus

    PubMed

  87. 特集 除菌後時代を迎えた胃癌診療 -残された課題を巡って 1 .除菌後胃癌を巡る課題(3)除菌後胃癌の診断を巡って e.除菌後胃癌-診断困難例を巡って ② 除菌による側方進展への影響

    伊藤 信仁, 舩坂 好平, 古川 和宏, 角嶋 直美, 中村 正直, 藤城 光弘

    臨床消化器内科   Vol. 35 ( 12 ) page: 1459 - 1464   2020.10

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000001420

    CiNii Research

  88. 特集 ガイドラインには書いていない-胃癌治療のCQ -ESD後の追加胃切除の真の適応-消化器内科医はどのような場合に心から追加胃切除を勧めるか?

    伊藤 信仁, 古川 和宏, 角嶋 直美, 柴田 寛幸, 平井 恵子, 飛田 恵美子, 鈴木 孝弘, 鈴木 智彦, 室井 航一, 廣瀨 崇, 和田 啓孝, 古根 聡, 中村 正直, 藤城 光弘

    臨床外科   Vol. 75 ( 10 ) page: 1147 - 1151   2020.10

     More details

    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1407213069

    CiNii Research

  89. 特集 食道胃接合部癌update III. 治療 1.食道胃接合部癌の内視鏡治療適応と根治基準

    鈴木 孝弘, 古川 和宏, 角嶋 直美, 古根 聡, 伊藤 信仁, 和田 啓孝, 廣瀬 崇, 室井 航一, 鈴木 智彦, 飛田 恵美子, 平井 恵子, 柴田 寛幸, 中村 正直, 藤城 光弘

    外科   Vol. 82 ( 11 ) page: 1120 - 1123   2020.10

     More details

    Publisher:南江堂  

    DOI: 10.15106/j_geka82_1120

    CiNii Research

  90. 特集 分子標的時代のIBD 診療 -IBD の寛解導入,寛解維持の実践 3.IBD 治療における寛解導入と寛解維持に関するトピック(6)IBD センターの構想と効果,社会的役割

    中村 正直, 中山 吾郎, 山村 健史, 服部 憲史, 澤田 つな騎, 佐藤 雄介, 藤城 光弘

    臨床消化器内科   Vol. 35 ( 10 ) page: 1275 - 1279   2020.8

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000001326

    CiNii Research

  91. 特集 クローン病小腸狭窄病変に対する内視鏡的バルーン拡張術─基本からピットフォールまで Ⅱ.クローン病小腸狭窄病変に対するバルーン拡張術(4)クローン病におけるバルーン拡張術のコツ a.ダブルバルーン内視鏡の立場から

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 石川 恵里, 古川 和宏, 角嶋  直美, 藤城 光弘

    INTESTINE   Vol. 24 ( 3 ) page: 197 - 202   2020.8

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/int.0000000486

    CiNii Research

  92. 特集 分子標的時代のIBD 診療 -IBD の寛解導入,寛解維持の実践 3.IBD 治療における寛解導入と寛解維持に関するトピック(5)UC 関連腫瘍の早期診断と治療

    山村 健史, 中村 正直, 前田 啓子, 澤田 つな騎, 石川 恵里, 喜田 裕一, 古川 和宏, 川嶋 啓揮, 藤城 光弘

    臨床消化器内科   Vol. 35 ( 10 ) page: 1267 - 1273   2020.8

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000001325

    CiNii Research

  93. 特集 薬剤性消化器疾患の診療 4 .その他の薬剤性消化器疾患(4)免疫チェックポイント阻害薬による消化器障害

    伊藤 隆徳, 澤田 つな騎, 中村 正直, 本多 隆, 石上 雅敏, 藤城 光弘

    臨床消化器内科   Vol. 35 ( 7 ) page: 759 - 765   2020.6

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000001205

    CiNii Research

  94. TOPICS 文献紹介〈炎症関連*〉 クローン病診断に有用なカプセル内視鏡所見に関する検討─本邦多施設症例対照研究〔Review from ─ J Gastroenterol 2019;54:249-260〕

    江﨑 幹宏, 松本 主之, 大宮 直木, 鷲尾 恵万, 森下 寿文, 坂本 圭, 安倍 弘生, 山本 章二朗, 金城 徹, 冨樫 一智, 渡辺 憲治, 平井 郁仁, 中村 正直, 能田 貞治, 芦塚 伸也, 大森 鉄平, 河内 修司, 梁井 俊一, 冬野 雄太, 平野 敦士, 梅野 淳嗣, 北園 孝成, 金城 福則, 渡辺 守, 松井 敏幸, 鈴木 康夫

    INTESTINE   Vol. 24 ( 2 ) page: 157 - 159   2020.6

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/int.0000000466

    CiNii Research

  95. 連載 手技の解説 Sit‒stand endoscopic workstation-人間工学から考える内視鏡

    松崎 一平, 服部 昌志, 山本 孔次郎, 榎原 毅, 中村 正直, 藤城 光弘

    臨床消化器内科   Vol. 35 ( 6 ) page: 661 - 666   2020.5

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000001177

    CiNii Research

  96. Nonexposed wall-inversion surgery as a novel local resection method for neoplasms in the gastrointestinal tract

    Fujishiro Mitsuhiro, Furukawa Kazuhiro, Yamamura Takeshi, Nakamura Masanao, Honda Takashi, Maeda Osamu, Ishigami Masatoshi, Kawashima Hiroki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 175 - 182   2020.5

     More details

    Language:Japanese   Publisher:Nagoya Journal of Medical Science  

    Nonexposed wall-inversion surgery was invented for the treatment of node-negative gastrointestinal tumors that are difficult to be resected using the endoluminal approach alone. The advantages of this surgery include 1. full-thickness resection procedure of gastrointestinal wall with minimum necessary tumor-negative margins and 2. less risk of bacterial contamination and tumor seeding into the abdominal cavity. We conducted a PubMed search to select relevant articles published until the end of October 2019 for pooled case analyses using the keyword "nonexposed wall-inversion surgery, " Based on our search, we enrolled the data of 88 gastric lesions and 1 duodenal lesion retrieved from 7 case report articles and 4 original articles of clinical cases. The gastric lesions consisted of 59 gastrointestinal stromal tumors, 7 ectopic pancreases, 5 leiomyomas, 3 early gastric cancers, and 14 others, with a mean maximal tumor diameter of 25.0 mm. In 5 lesions (5.7%), intraoperative perforation was performed, and 2 lesions (2.3%) were retrieved by the transabdominal route. All 4 major postoperative complications (4.5%) were managed without resurgical interventions. The duodenal case, neuroendocrine tumor, measuring 13 mm in size, was curatively resected without complications. Nonexposed wall-inversion surgery appears to be an acceptable treatment for node-negative gastric and duodenal tumors; however, further accumulation of cases is necessary to confirm the feasibility.

    DOI: 10.18999/nagjms.82.2.175

    Web of Science

    Scopus

    PubMed

  97. An International Study on the Diagnostic Accuracy of the Japan Narrow-Band Imaging Expert Team Classification for Colorectal Polyps Observed with Blue Laser Imaging

    Suzuki Hiroto, Yamamura Takeshi, Nakamura Masanao, Hsu Chen-Ming, Su Ming-Yao, Chen Tsung-Hsing, Chiu Cheng-Tang, Hirooka Yoshiki, Goto Hidemi

    DIGESTION   Vol. 101 ( 3 ) page: 339 - 346   2020.5

     More details

    Language:Japanese   Publisher:Digestion  

    Background: The Japan narrow-band imaging Expert Team (JNET) classification of colorectal polyps based on magnifying endoscopy is used in Japan, but not worldwide. The objective of this study was to clarify differences of diagnostic accuracy between JNET users in Japan and non-JNET users in other countries. Methods: A total of 185 colorectal tumors were assessed. Six endoscopists (3 each from Japan and Taiwan) participated in the study. The Japanese endoscopists normally used the JNET classification and the Taiwanese endoscopists normally used the narrow-band imaging International Colorectal Endoscopic classification for diagnosis of colorectal tumors. After receiving a lecture on the JNET classification, they all observed one blue laser imaging magnified image per lesion and performed diagnosis based on the JNET classification. Results: Diagnostic ability was equivalent for Type 1, Type 2A, and Type 2B. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value of Type 3 for deep submucosal invasive carcinoma was, respectively, 44.4, 98.3, 57.1, and 97.2% in Group J and 70.0, 94.7, 40.4, and 98.4% in Group T. The PPV for diagnosis of Type 3 with a high confidence was significantly higher in Group J than in Group T (81.8% [55.4-94.6] vs. 44.4% [33.6-50.9], p < 0.05). Conclusions: The PPV for Type 3 differed between the 2 groups, suggesting the need to become familiar with differentiation between Type 2B and Type 3.

    DOI: 10.1159/000499856

    Web of Science

    Scopus

    PubMed

  98. COMPARISON OF 8- AND 10-MM DIAMETER FULLY COVERED SELFEXPANDABLE METAL STENTS: A MULTICENTER PROSPECTIVE STUDY IN PATIENTS WITH DISTAL MALIGNANT BILIARY OBSTRUCTION

    KAWASHIMA Hiroki, HASHIMOTO Senju, OHNO Eizaburo, ISHIKAWA Takuya, MORISHIMA Tomomasa, MATSUBARA Hiroshi, SUGIMOTO Hiroyuki, NONOGAKI Koji, KANAMORI Akira, HARA Kazuo, KUWAHARA Takamichi, NAKAMURA Masanao, MIYAHARA Ryoji, ISHIGAMI Masatoshi, ANDO Masahiko, HIROOKA Yoshiki, The Nagoya Biliary Stent Study(NABIS) -01 Group.

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 62 ( 5 ) page: 593 - 603   2020

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>Objectives: The time to recurrent biliary obstruction (TRBO) of unresectable distal malignant biliary obstruction is generally thought to be longer when a self-expandable metal stent (SEMS) with a thicker inner diameter is used for drainage, but the dependence on the inner diameter using a fully covered SEMS (FCSEMS) is uncertain. The objective of this multicenter prospective study was to compare TRBO and adverse events, such as cholecystitis and pancreatitis, in treatment of patients with unresectable malignant biliary obstruction using 8- and 10- mm diameter FCSEMS.</p><p>Methods: Eighteen tertiary-care centers participated in the study. Patients were allocated to the 8- and 10-mm diameter groups. TRBO, non-inferiority of the 8-mm FCSEMS, overall survival time, frequency and type of adverse events, and nonrecurrent biliary obstruction (RBO) rate at the time of death were compared between the two groups.</p><p>Results: Median TRBO did not differ significantly between the 8-mm (<i>n</i>=102) and 10-mm (<i>n</i>=100) groups (275 vs 293 days, <i>P</i>=0.971). The hazard ratio of the 8- to 10-mm groups was 0.90 (80% confidence interval, 0.77-1.04; upper limit lower than the acceptable hazard ratio [1.33] of the null hypothesis). Based on these findings, the 8-mm diameter stent was determined to be non-inferior to the 10-mm diameter stent. Survival time, incidence of adverse events and non-RBO rate at the time of death did not differ significantly between the two groups.</p><p>Conclusions: Time to RBO with an 8-mm diameter FCSEMS was non-inferior to that with a 10-mm diameter FCSEMS. This finding is important for development of future SEMS.</p>

    DOI: 10.11280/gee.62.593

    Scopus

    CiNii Research

  99. COLOR INFORMATION FROM LINKED COLOR IMAGING IS ASSOCIATED WITH INVASION DEPTH AND VASCULAR DIAMETER IN SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA

    KOBAYASHI Kenichi, MIYAHARA Ryoji, FUNASAKA Kohei, FURUKAWA Kazuhiro, SAWADA Tsunaki, MAEDA Keiko, YAMAMURA Takeshi, ISHIKAWA Takuya, OHNO Eizaburo, NAKAMURA Masanao, KAWASHIMA Hiroki, NAKAGURO Masato, OKUMURA Yuki, HIROOKA Yoshiki, FUJISHIRO Mitsuhiro

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 62 ( 9 ) page: 1624 - 1633   2020

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>Objectives: Accurate diagnosis of invasion depth is important for reliable treatment of esophageal squamous cell carcinoma (ESCC), but it is limited to the muscularis mucosae to slight submucosal invasion (MM/SM1). The diagnostic accuracy of invasion depth is unsatisfactory and remains to be improved. We aimed to investigate the association between the color of the superficial ESCC and invasion depth using linked color imaging (LCI) under light-emitting diode (LED) light sources.</p><p>Methods: Lesions diagnosed as superficial ESCC were observed using white light imaging and then by LCI. The color values were calculated using Commission Internationale de lʼEclariage - L<sup>*</sup>a<sup>*</sup>b<sup>*</sup> color space, and the color difference was calculated according to invasion depth. The vascular diameters and vascular angles of the intrapapillary capillary loops were pathologically analyzed. Their correlation with mucosal color was also investigated by LCI.</p><p>Results: In all, 52 lesions from 48 patients were analyzed. On the basis of invasion depth, the color difference between the normal mucosa and the lesion was larger in the MM/SM1 or deeper group than in the epithelium and the lamina propria mucosa (EP/LPM) group using LCI (<i>P</i>=0.025). The vascular diameter was positively correlated with the b<sup>*</sup> color value (correlation coefficient=0.302, <i>P</i>=0.033).</p><p>Conclusion: Observation using LCI under LED light sources may improve the endoscopic diagnosis of the invasion depth of superficial ESCC. Further research is needed to validate its usefulness. (UMIN000024615)</p>

    DOI: 10.11280/gee.62.1624

    Scopus

    CiNii Research

  100. Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ohashi Ayako, Kajikawa Go, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    Internal Medicine   Vol. 59 ( 23 ) page: 3009 - 3014   2020

     More details

    Language:Japanese   Publisher:The Japanese Society of Internal Medicine  

    <p>Granulocyte and monocyte adsorptive apheresis (GMA) is occasionally introduced as an alternative combination therapy after loss of response to biologics in ulcerative colitis (UC) patients. However, there have been no reports of the concomitant use of vedolizumab (VDZ) and GMA for the initial induction of UC. A 20-year-old man with refractory UC was admitted for recrudescence. VDZ monotherapy had previously been introduced but was ineffective. Therefore, he received scheduled combination of VDZ and GMA and achieved clinical remission. The combination of two different approaches to inhibit the migration of leukocytes into the inflamed tissue led to satisfactory clinical outcomes. </p>

    DOI: 10.2169/internalmedicine.5302-20

    Web of Science

    Scopus

    PubMed

    CiNii Research

  101. 単発性小腸Peutz-Jeghers型ポリープに関する臨床的検討

    鳥山 和浩, 中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 石川 恵里, 梶川 豪, 村手 健太郎, 喜田 裕一, 江崎 正哉, 濱崎 元伸, 角嶋 直美, 古川 和宏, 藤城 光弘

    日本小腸学会学術集会プログラム・抄録集   Vol. 4 ( 0 ) page: 39 - 39   2020

     More details

    Language:Japanese   Publisher:日本小腸学会  

    <p>【背景】Peutz-Jeghers症候群(PJS)は食道を除く全消化管において上皮の過形成と粘膜筋板のポリープ内への樹枝状増生を特徴とする過誤腫性ポリポーシスと皮膚、粘膜の色素斑を特徴とする常染色体優性遺伝性疾患である。一方、家族歴や皮膚、粘膜の色素沈着を伴わない単発性のPeutz-Jeghers型ポリープ(PJP)を認めることがあるが、その臨床的特徴に関する報告は少ないのが現状である。</p><p>【目的】単発性小腸PJPにおける臨床的特徴を明らかにする。</p><p>【対象】2007年4月から2020年5月までに当院で内視鏡治療を施行し、病理組織学的にPJPと診断された単発性小腸PJP16症例。</p><p>【結果】レトロスペクティブにカルテ、内視鏡画像をレビューした。性別は男性10例、女性6例、診断時年齢中央値(範囲)は61(18-82)歳。診断契機は貧血7例、黒色便5例、腹痛1例、イレウス症状1例、他疾患精査時の偶発的発見が2例。原発部位は空腸14例、回腸2例で、腫瘍径中央値(範囲)は25(4-35)mm。切除したPJP全病変で病変内に悪性腫瘍の併存は認めなかった。癌の既往歴を有したのは6例(前立腺癌2例、舌癌1例、大腸癌1例、胃癌1例、子宮体癌1例)。観察期間中央値(範囲)は4.6(0.1-53.7)ヶ月で再発並びに関連死は認めなかった。</p><p>【考察】単発性小腸PJPにおいては診断時の年齢が高く、発見契機としては出血関連症状が多く、病変部位は空腸に多い特徴があった。</p><p>【結語】当院で経験した単発性小腸PJPの臨床的特徴を検討した。今後更なる症例の蓄積が必要である。</p>

    DOI: 10.32264/shocho.4.0_39

    CiNii Research

  102. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope

    Suzuki Hiroto, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    Internal Medicine   Vol. 59 ( 15 ) page: 1795 - 1801   2020

     More details

    Language:Japanese   Publisher:The Japanese Society of Internal Medicine  

    <p><b>Objective </b>With the advent of endoscopic treatment, the detailed diagnosis of colorectal neoplasms made using magnifying colonoscopy has become increasingly important. However, insertion difficulty causes pain in unsedated colonoscopy. The aim of this prospective observational study was to clarify the factors associated with a patient's pain in unsedated colonoscopy using a magnifying endoscope. </p><p><b>Methods </b>Patient pain was assessed using a numerical rating scale (0-10) immediately after the procedure. We defined 5 as mild enough pain that patients would not be reluctant to undergo another colonoscopy. Acceptable pain was defined as 5 or less and severe pain was defined as 8 to 10. Univariate and multivariate linear regression analyses were performed using the pain scale score as a dependent variable. </p><p><b>Results </b>A total of consecutive 600 patients undergoing unsedated colonoscopies were evaluated to assess their abdominal pain. The completion rate was 99.5% (597/600). The mean pain scale score was 3.88±2.38. The rate of acceptable pain was 80.5% (483/600). The rate of severe pain was 6.7% (40/600) including the incomplete cases. A comparison of polyp-positive and polyp-negative cases revealed no marked difference in patient pain (3.82±2.24 vs. 3.94±2.49, respectively; p=0.590) or insertion time (6.62±3.98 vs. 6.29±4.21, p=0.090), while more observation time was needed in polyp-positive cases than in polyp-negative ones (16.30±4.95 vs. 13.08±4.69, p<0.01). Univariate and multivariate linear regression analyses revealed that an older age, colectomy, antispasmodic agent use, and a small-diameter endoscope were significant factors associated with less patient pain. In particular, a small-diameter endoscope induces significantly more acceptable pain than a non-small diameter endoscope [85.63% (274/320) vs. 73.93% (207/280), p=0.00003]. </p><p><b>Conclusion </b>Unsedated colonoscopy using a magnifying endoscope by an expert may result in acceptable pain levels. The use of an antispasmodic agent, particularly hyoscine N-butyl bromide, and a small-diameter endoscope are recommended for reducing abdominal pain during unsedated colonoscopy. </p>

    DOI: 10.2169/internalmedicine.4267-19

    Web of Science

    Scopus

    PubMed

    CiNii Research

  103. カプセル内視鏡内服不可能および内視鏡的挿入補助具に関する全国多施設共同調査(AdvanCE-J study)

    大宮 直木, 岡 志郎, 中村 正直, 中山 佳子, 岩間 達, 田中 信治, 田尻 久雄

    日本小腸学会学術集会プログラム・抄録集   Vol. 4 ( 0 ) page: 45 - 45   2020

     More details

    Language:Japanese   Publisher:日本小腸学会  

    <p>【背景・目的】カプセル内視鏡は乳児・年少児や稀に成人でも内服困難で、また長時間食道内や胃内に停滞することもある。その際、上部消化管内視鏡下でネットやスネア、挿入補助器具のAdvanCE®(US Endoscopy社製、国内販売:富士フイルムメディカル)を用いて十二指腸に誘導する必要がある。AdvanCEは2013年に薬事承認されたが、現在保険未承認である。本邦小児例におけるAdvanCEの有用性については、すでにIwamaらが2013~2017年に18歳未満でAdvanCEによる挿入補助を行った154例を対象に、90%で十二指腸への誘導が可能であり、89%でカプセル内視鏡による全小腸観察が可能で重篤な有害事象の発生はなかったと報告している(Eur J Gastroenterol Hepatol 2019; 31:1502-1507)。ただ、これまで成人例でのカプセル内視鏡の内服困難例、食道・胃内での停滞例での挿入補助具の使用報告は少ない。そこで、本研究ではAdvanCEの手技料加算承認を目標とし、本邦小児・成人例におけるカプセル内視鏡挿入補助器具の使用実態について調査し、その有効性および安全性を遡及的に多施設共同で検討する(課題名:カプセル内視鏡内服不可能および内視鏡的挿入補助具に関する全国多施設共同調査、Multicenter survey of impossible swallowing of capsule endoscopy and use of capsule delivery system including AdvanCE system in Japan:AdvanCE-J study)。</p><p>【方法】小腸・大腸カプセル内視鏡検査、パテンシーカプセルによる消化管通過性検査を行った症例を対象に以下の項目を調査する。今後倫理委員会承認後に藤田医科大学のREDCap®を用いたオンライン登録で入力を行う予定である。1.検査数(導入開始~直近)、2.そのうちカプセル内服不可または不可と予測された件数、3.内服不可(予測含む)および挿入補助具使用した各症例の内訳:性別、年齢、身長、体重、検査契機、病名、既往歴、カプセル内視鏡前のパテンシーカプセルによる消化管通過性検査の有無、カプセル嚥下可能・不可・不可(予測)、嚥下不可(予測含む)であった理由、対応(カプセル検査中止、使用機材種類)、補助具使用の理由、鎮静の有無、補助具挿入の施行場所、デリバリー時間、カプセル留置部位、有害事象、全小腸(大腸)観察の有無、カプセル内視鏡所見、各施設の補助具使用ルール。</p>

    DOI: 10.32264/shocho.4.0_45

    CiNii Research

  104. Endoscopic screening for gastric cancer

    FURUKAWA Kazuhiro, NAKAMURA Masanao, FUJISHIRO Mitsuhiro

    Nippon Shokakibyo Gakkai Zasshi   Vol. 117 ( 6 ) page: 469 - 476   2020

     More details

    Language:Japanese   Publisher:The Japanese Society of Gastroenterology  

    DOI: 10.11405/nisshoshi.117.469

    Scopus

    PubMed

    CiNii Research

  105. A Case Where Administration of Ustekinumab Maintained the Intestinal Patency After Balloon Dilation for Small Intestinal Stenosis Caused by Crohn's Disease

    Murate Kentaro, Nakamura Masanao, Fujishiro Mitsuhiro

    INFLAMMATORY BOWEL DISEASES   Vol. 25 ( 11 ) page: E140 - E140   2019.11

     More details

    Language:Japanese   Publisher:Oxford University Press (OUP)  

    DOI: 10.1093/ibd/izz166

    Web of Science

    Scopus

    PubMed

    CiNii Research

  106. Learning curve for mastery of colorectal endoscopic submucosal dissection: Perspectives from a Japanese cohort of more than 500 procedures

    Pu L. Zorron Cheng Tao, Yamamura T., Kaosombatwattana U., Esaki M., Nakamura M., Edwards S., Burt A., Hirooka Y., Singh R., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 34   page: 20 - 21   2019.9

     More details

    Language:Japanese  

    Web of Science

  107. Effect of time of day and specialty on polyp detection rates in Australia.

    Zorron Cheng Tao Pu L, Lu K, Ovenden A, Rana K, Singh G, Krishnamurthi S, Edwards S, Wilson B, Nakamura M, Yamamura T, Ruszkiewicz A, Hirooka Y, Burt AD, Singh R

    Journal of gastroenterology and hepatology   Vol. 34 ( 5 ) page: 899 - 906   2019.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.14566

    Web of Science

    Scopus

    PubMed

  108. 今月の主題 知っておきたい小腸疾患 主題 小腸の非腫瘍性疾患-小腸リンパ管拡張症

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 丹羽 慶樹, 石川 恵里, 大塚 裕之, 鈴木 悠土, 西川 貴広, 石田 哲也, 久野 剛史, 服部 峻, 山田 啓策, 廣岡 芳樹, 藤城 光弘

    胃と腸   Vol. 54 ( 4 ) page: 532 - 536   2019.4

     More details

    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1403201630

    CiNii Research

  109. Neoadjuvant CAPOX and bevacizumab alone for locally advanced rectal cancer: long-term results from the N-SOG 03 trial.

    Tomida A, Uehara K, Hiramatsu K, Maeda A, Sakamoto E, Okada Y, Kurumiya Y, Nakayama G, Nakamura M, Aiba T, Nagino M, Of the Nagoya Surgical Oncology Group.

    International journal of clinical oncology   Vol. 24 ( 4 ) page: 403 - 410   2019.4

     More details

    Language:English   Publisher:International Journal of Clinical Oncology  

    Background: Neoadjuvant chemotherapy (NAC) alone for locally advanced rectal cancer (LARC) remains an experimental treatment, and the efficacy in terms of long-term outcome has not been fully elucidated. The N-SOG 03 trial examined the safety and efficacy of neoadjuvant CAPOX and bevacizumab (Bev) without radiotherapy in patients with poor-risk LARC. Methods: Thirty-two patients with MRI-defined LARC received neoadjuvant CAPOX and Bev followed by curative resection between 2010 and 2011. The overall survival (OS), progression-free survival (PFS), and local-relapse rate (LRR) were calculated using the Kaplan–Meier method, and the risk factors were evaluated by multivariate analysis using the Cox proportional hazard models. This trial is registered with UMIN, number 000003507. Results: In the entire cohort, the 5-year OS was 81.3%. Because of disease progression during chemotherapy, 3 patients ultimately did not undergo curative surgery. As a result, 29 patients underwent R0/1 resection. Among these 29 patients, the 5-year OS, PFS, and LRR were 89.7%, 72.4% and 13.9%, respectively. In multivariate analysis, cT4b tumor was an independent poor prognostic factor for OS and LRR, and ypT4b tumor and absence of N down-staging were independent poor prognostic factors for PFS. Conclusions: Patients with cT4b tumor were not suitable for NAC alone. However, the long-term outcomes of the other patients were satisfactory, and NAC alone might be an option for treatment of LARC. N down-staging was likely to bring favorable PFS, even in patients with cStage III.

    DOI: 10.1007/s10147-018-1372-6

    Web of Science

    Scopus

    PubMed

  110. 腸リンパ管拡張症の診断と治療

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 藤城 光弘

    日本小腸学会学術集会プログラム・抄録集   Vol. 3 ( 0 ) page: 34_2 - 34_2   2019

     More details

    Language:Japanese   Publisher:日本小腸学会  

    <p>【背景・目的】 小腸内視鏡診断の進歩により腸リンパ管拡張症(Intestinal lymphangiectasia:IL)を含む蛋白漏出性腸症の小腸精査が可能になった。本研究の目的はILの臨床経過を後ろ向きに評価し、その特徴を明らかにしたうえでより良い治療法を模索することであった。</p><p>【対象と方法】 対象は2003年6月から2019年6月までにILと診断された17例(男性9例、女性8例、発症年齢は中央値37歳、0-75歳)であった。ILの診断は蛋白漏出性腸症と診断され且つ内視鏡下生検もしくは剖検にて病理学的に腸リンパ管拡張を認めたもので、他疾患が否定的であったものとした。白色絨毛、散布性白点を有する白色絨毛群(WV)と、異常なしもしくは軽度絨毛腫大、ケルクリング襞腫大を認める非白色絨毛群(NWV)に分けて臨床成績を比較検討した。</p><p>【結果】 WV、NWVは10例、7例であった。平均血清アルブミン値(g/dl)はWV:NWV = 2.0:1.2でNWVにおいて有意に低かった(P = 0.0061)。平均<i>α</i>1アンチトリプシンクリアランスはWV:NWV = 132:284(P = 0.0509)であった。ステロイド治療への反応はWV:NWV = 2/7:6/6 例でみられた。平均観察期間48箇月において1例のILが影響した死亡例を経験したが、重篤な真菌感染症によるものであった。</p><p>【結論】 NWV群は蛋白漏出は多いがステロイドへの反応がWV群よりも良好であった。治療のゴールドスタンダードは存在せず可能な可能で効果があるものを続けることが現状であった。</p>

    DOI: 10.32264/shocho.3.0_34_2

    CiNii Research

  111. MULTICENTER FEASIBILITY STUDY OF BOWEL PREPARATION WITH CASTOR OIL FOR COLON CAPSULE ENDOSCOPY

    OHMIYA Naoki, HOTTA Naoki, MITSUFUJI Shoji, NAKAMURA Masanao, OMORI Takafumi, MAEDA Kohei, OKUDA Kotaro, YATSUYA Hiroshi, TAJIRI Hisao

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 61 ( 12 ) page: 2646 - 2655   2019

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>Background and Aim: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster.</p><p>Methods: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged.</p><p>Results: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (<i>P</i><0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; <i>P</i>=0.0048), male gender (adjusted OR, 3.20; <i>P</i>=0.0051), and use of castor oil (adjusted OR, 6.29; <i>P</i>=0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (<i>P</i> = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (<i>P</i> = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively.</p><p>Conclusion: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.</p>

    DOI: 10.11280/gee.61.2646

    Scopus

    CiNii Research

  112. A CASE OF MULTIPLE HEMANGIOMAS OF THE SMALL INTESTINE TREATED BY SCLEROTHERAPY USING DOUBLE-BALLOON ENTEROSCOPY

    YAMADA Keisaku, YAMAMURA Takeshi, NAKAMURA Masanao, SAWADA Tsunaki, MIZUTANI Yasuyuki, MAEDA Keiko, FURUKAWA Kazuhiro, MIYAHARA Ryoji, YOKOI Takio, HIROOKA Yoshiki

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 61 ( 6 ) page: 1231 - 1236   2019

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>A 70-year-old male was referred to our department due to melena which began one month previously. Esophagogastroduodenoscopy and colonoscopy were performed, but no signs of active bleeding were found. Therefore, capsule endoscopy was performed to check for small intestinal lesions. Capsule endoscopy revealed multiple protruded lesions and bloody intestinal fluid in a lesion in the upper ileum. Double-balloon enteroscopy revealed multiple protruded lesions suspicious of being hemangioma. Endoscopic mucosal resection of a lesion was performed, and it was finally diagnosed as capillary hemangioma. Sclerotherapy was performed by injecting polidocanol in the multiple hemangiomas. After this treatment, there was no melena and the follow-up endoscopy showed decreased size of the lesions. Thus, sclerotherapy was found to be useful in the treatment of multiple hemangiomas in the small intestine.</p>

    DOI: 10.11280/gee.61.1231

    Scopus

    CiNii Research

  113. Fecal calprotectin reflects endoscopic activity in patients with small-bowel Crohn's disease according to double-balloon endoscopy findings

    Matsuura Rinzaburo, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Furukawa Kazuhiro, Ishikawa Takuya, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 2 ) page: 257 - 266   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nagoya University  

    Fecal calprotectin (FC) has drawn attention as a biomarker in the evaluation of Crohn's disease (CD). However, few reports have provided a detailed examination of the relationship between small-bowel CD lesions and FC levels. The present study aimed to examine the entire small bowel using double-balloon endoscopy (DBE) and to determine the relationship between the endoscopic activity in small-bowel CD and FC levels. Twenty small-bowel CD patients, who underwent DBE, were prospectively enrolled. Endoscopic evaluation was based on the simple endoscopic score for CD, with the small bowel divided into four regions. This score was defined as the double-balloon endoscopic score for CD (DES-CD). Furthermore, to focus on mucosal membrane damage, we used the partial DES-CD (pDES-CD), in which presence of stenosis was excluded from DES-CD. DES-CD revealed a correlation with FC (γ = 0.691, P = 0.001) and C-reactive protein (CRP) (γ = 0.631, P = 0.003) levels. Furthermore, pDES-CD showed a correlation with the FC level (γ = 0.747, P &lt
    0.001), erythrocyte sedimentation rate (γ = 0.492, P = 0.028), and the CRP level (γ = 0.605, P = 0.005). CD Activity Index and endoscopic score showed no correlation. Our results revealed a correlation between the endoscopic activity in small-bowel CD and FC levels. Furthermore, pDES-CD showed a strong correlation with FC levels. This may be because FC levels were elevated due to mucosal membrane damages, rather than stenoses.

    DOI: 10.18999/nagjms.80.2.257

    Web of Science

    Scopus

    PubMed

  114. Nomogram-based prediction of rebleeding in small bowel bleeding patients: The 'PRSBB' score Reviewed

    Genta Uchida, Yoshiki Hirooka, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Masanobu Matsushita, Hiroki Suhara, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto

    Scientific Reports   Vol. 8 ( 1 ) page: 6378   2018.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Nature Publishing Group  

    Small bowel capsule endoscopy (SBCE) and balloon-assisted endoscopy (BAE) have revolutionized the diagnosis and treatment of small bowel bleeding (SBB), allowing access to the small bowel and identification of specific bleeding lesions. However, some patients experience rebleeding after small bowel investigation, and there are no definitive algorithms for determining the most appropriate follow-up strategy in SBB patients. We developed and validated a nomogram that can predict rebleeding risk and be used to develop a risk-stratified follow-up strategy in SBB patients. A retrospective study was performed using data from 401 SBB patients who underwent SBCE at Nagoya University Hospital. We developed and internally validated a predictive model for rebleeding in the form of a nomogram using Cox regression models and a bootstrap resampling procedure. Optimal risk factors were selected according to the least absolute shrinkage and selection operator (LASSO). The LASSO method identified 8 independent predictors of rebleeding that could be assessed to obtain a 'predicting rebleeding in SBB', or 'PRSBB' score: age, sex, SBB type, transfusion requirement, cardiovascular disease, liver cirrhosis, SBCE findings, and treatment. The c-statistic for the predictive model was 0.681. In conclusion, our PRSBB score can help clinicians devise appropriate follow-up plans.

    DOI: 10.1038/s41598-018-24868-0

    Web of Science

    Scopus

    PubMed

  115. 特集 緊急内視鏡の適応と実際 5 .小腸出血

    中村 正直, 大宮 直木, 廣岡 芳樹, 後藤 秀実

    臨床消化器内科   Vol. 33 ( 5 ) page: 505 - 511   2018.4

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000000317

    CiNii Research

  116. ASSOCIATIONS BETWEEN DRUGS AND SMALL-BOWEL MUCOSAL BLEEDING: MULTICENTER CAPSULE-ENDOSCOPY STUDY

    NIIKURA Ryota, YAMADA Atsuo, MAKI Koutarou, NAKAMURA Masanao, WATABE Hirotsugu, FUJISHIRO Mitsuhiro, OKA Shiro, ESAKI Motohiro, FUJIMORI Shunji, NAKAJIMA Atsushi, OHMIYA Naoki, MATSUMOTO Takayuki, TANAKA Shinji, KOIKE Kazuhiko, SAKAMOTO Choitsu

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 60 ( 11 ) page: 2428 - 2439   2018

     More details

    Language:Japanese   Publisher:Japan Gastroenterological Endoscopy Society  

    <p>Background and Aim: Although several drugs may induce small-bowel mucosal injuries, it is unclear whether these injuries contribute to overt small-bowel bleeding. This study was designed to evaluate the associations between drug use and small-bowel mucosal injury and between these mucosal injuries and overt bleeding in a disease-relevant population.</p><p>Methods: We retrospectively studied patients with suspected small-bowel diseases who underwent capsule endoscopy between 2010 and 2013. Drug exposure, Charlson Comorbidity Index, smoking, and alcohol consumption were assessed before capsule endoscopy. Adjusted odds ratios (AOR) and confidence intervals (CI) were estimated for small-bowel mucosal injury and small-bowel overt bleeding. </p><p>Results: In total, 850 patients were analyzed during the study period. Median age was 64 years, and 544 patients (64.0%) were men. Among the patients with small-bowel mucosal injury (<i>n</i> = 60) and without mucosal injury (<i>n</i> = 705), use of nonsteroidal anti-inflammatory drugs (NSAIDs) (AOR 1.8, 95% CI 1.01-3.31) was significantly associated with an increased risk of small-bowel mucosal injury compared with non-use. Patients with small-bowel mucosal injury with overt bleeding (<i>n</i> = 85) and without overt bleeding (<i>n</i> = 60) were compared, and no significant difference between the groups in the usage rates for NSAIDs, thienopyridine, other antiplatelets, anticoagulants, acetaminophen, tramadol hydrochloride, or steroids was revealed, even after adjusting for confounders.</p><p>Conclusion: Although the use of NSAIDs was significantly associated with an increased risk of small-bowel mucosal injury, no significant associations were observed between the use of such drugs and small-bowel overt bleeding.</p>

    DOI: 10.11280/gee.60.2428

    CiNii Research

  117. 特集 小腸の炎症性病変を見直す Ⅱ.各論  ( 6 )小腸リンパ管拡張症の臨床像と治療

    中村 正直, 大宮 直木, 廣岡 芳樹, 後藤 秀実

    INTESTINE   Vol. 21 ( 6 ) page: 531 - 535   2017.11

     More details

    Publisher:日本メディカルセンター  

    DOI: 10.19020/int.0000000117

    CiNii Research

  118. 今月の主題 消化管結核の診断と治療─最近の進歩 主題症例 抗結核薬による診断的治療が奏効した小腸多発潰瘍の1例

    齋藤 雅之, 中村 正直, 渡辺 修, 山村 健史, 松下 正伸, 中野 有泰, 大島 啓嗣, 佐藤 淳一, 松浦 倫三郎, 舩坂 好平, 大野 栄三郎, 川嶋 啓揮, 宮原 良二, 廣岡 芳樹, 後藤 秀実

    胃と腸   Vol. 52 ( 2 ) page: 233 - 238   2017.2

     More details

    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1403200839

    CiNii Research

  119. Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors. International journal

    Takashi Hirose, Naomi Kakushima, Kazuhiro Furukawa, Satoshi Furune, Eri Ishikawa, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Kazuki Nishida, Takio Yokoi, Hiroki Kawashima, Mitsuhiro Fujishiro

    Digestion   Vol. 102 ( 6 ) page: 895 - 902   2021.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: Endoscopic criteria for the diagnosis of superficial nonampullary duodenal epithelial tumors (SNADETs) are lacking. The aim of this study was to explore the usefulness of endocytoscopy (ECS) in the duodenum. METHODS: A total of 77 ECS images stained by methylene blue and 58 images with double staining of methylene blue and crystal violet were obtained from 20 patients. Images were classified into 3 grades based on nuclear and villi atypia: EC A, B, and C. Diagnostic performance of ECS classification to predict histology and interobserver agreement was evaluated. The performance was compared between staining methods and ×520 or ×936 zoom. RESULTS: With methylene blue staining, high rates of accuracy, sensitivity, specificity, and positive predictive value (PPV) over 90% were achieved for tumor and nontumor diagnosis as assessed by EC A versus EC B. High rates of accuracy, sensitivity, PPV, and negative predictive value over 90% were achieved for the differentiation between the diagnosis of the Vienna category 3 and 4/5 as assessed by EC B versus C. The accuracy rate of interpreting ECS images with ×936 zoom among 10 endoscopists was 82%, and the interobserver agreement rate was 0.803 (Kendall's coefficient of concordance). In the ×936 zoom group, methylene blue staining was significantly associated with higher accuracy rate (odds ratio 1.76 [1.06-2.92], p value 0.0297). No benefit was observed by double staining. CONCLUSIONS: ECS diagnosis with methylene blue provides a high accuracy rate and good interobserver agreement to predict histology of SNADETs.

    DOI: 10.1159/000516512

    Web of Science

    Scopus

    PubMed

  120. Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasound. International journal

    Kunio Kataoka, Takuya Ishikawa, Eizaburo Ohno, Yasuyuki Mizutani, Tadashi Iida, Eri Ishikawa, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Masatoshi Ishigami, Hiroki Kawashima, Yoshiki Hirooka, Mitsuhiro Fujishiro

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 21 ( 7 ) page: 1364 - 1370   2021.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: Pancreatic metastases from renal cell carcinoma (PRCC) often appear many years after treatment of the primary tumor, and differentiation from pancreatic neuroendocrine neoplasm (PanNEN) can be challenging due to their hypervascularity. Here, we investigated the utility of endoscopic ultrasound (EUS) for differentiation of these conditions. METHODS: A retrospective analysis was performed in 17 and 79 consecutive patients with pathologically proven PRCC and non-functional PanNEN who were examined by EUS. In cases examined by EUS elastography or contrast-enhanced harmonic EUS (CH-EUS), the lesions were classified as stiff or soft, or into three vascular patterns as hypoechoic, isoechoic, and hyperechoic. CH-EUS images at 20 s, 40 s, 60 s, 3 min and 5 min were used for evaluation. EUS images were independently reviewed by two readers who were blinded to all clinical information. RESULTS: The patients with PRCC were significantly older than those with PanNEN (median, 71 (range, 45-81) vs. 58 (22-76), P = 0.001) and more often had multiple tumors (6/17 (35%) vs. 7/79 (9%), P = 0.010). In EUS findings, PRCC lesions significantly more frequently had a marginal hypoechoic zone (MHZ) (11/17 (65%) vs. 27/79 (34%), P = 0.028), being classified as soft (12/13 (92%) vs. 26/58 (45%), P = 0.002), and showed sustained hyperechoic vascular patterns at 5 min (7/8 (88%) vs. 4/59 (7%), P < 0.001) compared to PanNEN lesions. CONCLUSIONS: The presence of a MHZ, a soft lesion, and a sustained hyperechoic vascular pattern in EUS may be useful for differentiating PRCC from PanNEN.

    DOI: 10.1016/j.pan.2021.07.001

    Web of Science

    Scopus

    PubMed

  121. Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms. International journal

    Masaya Esaki, Takeshi Yamamura, Masanao Nakamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Eri Ishikawa, Hiroto Suzuki, Takeshi Kuno, Kentaro Yamada, Issei Hasegawa, Takuya Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Eizaburo Ohno, Hiroki Kawashima, Yoshiki Hirooka, Mitsuhiro Fujishiro

    Digestion   Vol. 102 ( 5 ) page: 701 - 713   2021.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: We aimed to compare the efficacy of endoscopic ultrasound elastography (EUS-EG) with that of magnifying chromoendoscopy (MCE) and endoscopic ultrasonography (EUS) for the diagnosis of the depth of invasion in colorectal neoplasms. This is an important clinical issue as the depth of invasion is associated with the risk of metastasis. METHODS: Consecutive patients with suspected superficial colorectal neoplasms, evaluated by MCE, EUS, and EUS-EG, for whom endoscopic submucosal dissection was considered, were enrolled in 2018 (derivation study) and in 2019-2020 (validation study). The primary clinical endpoint was the diagnostic yield differentiating intramucosal and shallow submucosal neoplasms from deep submucosal (dSM) and advanced colorectal cancers. In addition, inter- and intra-observer agreements of the elastic score of colorectal neoplasm (ES-CRN) were evaluated by 2 expert and 2 non-expert endoscopists. RESULTS: Thirty-one (33 lesions) and 50 (55 lesions) patients were enrolled in the derivation and validation studies, respectively. Sensitivity, specificity, positive, and negative predictive values, and accuracy of assessment of the depth of submucosal or deeper invasion in the derivation and validation groups were as follows: EUS-EG, 100/88.2/86.7/100/93.3% and 77.8/86.1/73.7/88.6/83.3%; MCE, 66.7/94.4/90.9/77.3/81.8% and 84.2/91.4/84.2/91.4/88.9%; and EUS, 93.3/77.8/77.8/93.3/84.8% and 89.5/65.7/58.6/92.0/74.1%, respectively. For the 2 expert endoscopists, interobserver agreement for the ES-CRN (first and second assessments) in the derivation group was 0.84 and 0.78, respectively; these values were 0.73 and 0.49, respectively, for the 2 non-expert endoscopists. DISCUSSION/CONCLUSION: All 3 modalities presented similar diagnostic yield. Inter- and intra-observer agreements of the ES-CRN were substantial, even for non-expert endoscopists. Therefore, EUS-EG may be a useful modality in determining the depth of invasion in colorectal neoplasms.

    DOI: 10.1159/000511589

    Web of Science

    Scopus

    PubMed

  122. A novel scoring system to predict therapeutic intervention for non-variceal upper gastrointestinal bleeding. International journal

    Nobuhito Ito, Kohei Funasaka, Kazuhiro Furukawa, Naomi Kakushima, Takashi Hirose, Koichi Muroi, Tomohiko Suzuki, Takahiro Suzuki, Emiko Hida, Takuya Ishikawa, Takeshi Yamamura, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Ryoji Miyahara, Mitsuhiro Fujishiro

    Internal and emergency medicine     2021.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Various scoring systems have been developed to predict the need for endoscopic treatment in patients with non-variceal upper gastrointestinal bleeding (NVUGIB). However, they have rarely been applied in clinical practice because the processes are complicated. The aim of this study was to establish a simple scoring system that predicts the need for endoscopic intervention in patients with NVUGIB. We retrospectively enrolled 509 consecutive patients with suspected NVUGIB who underwent emergency endoscopy. In the development cohort (from January 2016 to December 2018), risk factors that predict the need for endoscopic intervention were determined from 349 patients' data by multivariate logistic regression analysis. This led to the development of a novel scoring system named the Nagoya University score (N score). In the validation cohort (from January 2019 to September 2020), we evaluated the diagnostic value of the N score, the Hirosaki score, and the Glasgow-Blatchford scores (GBS) by receiver operating characteristic (ROC) curves using another 160 patients' data. Multivariate logistic regression analysis revealed syncope, hematemesis, blood urea nitrogen (BUN), and BUN/Cr as significant predictive factors for endoscopic intervention. In the validation study, the N score was superior to the GBS and equal to the Hirosaki score in predicting the endoscopic intervention (AUC, N score 0.776 [95% CI 0.702-0.851] vs. GBS 0.615 [0.523-0.708], Hirosaki 0.719 [0.636-0.803]). The N score revealed a sensitivity of 84.5% and a specificity of 61.8%. Our N score, which is consisted of only four factors, would select patients who require endoscopic intervention with high probability.

    DOI: 10.1007/s11739-021-02822-9

    Web of Science

    Scopus

    PubMed

  123. Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure. International journal

    Koichi Muroi, Naomi Kakushima, Kazuhiro Furukawa, Eri Ishikawa, Tsunaki Sawada, Takuya Ishikawa, Keiko Maeda, Takeshi Yamamura, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Kohei Funasaka, Ryoji Miyahara, Mitsuhiro Fujishiro

    Digestive diseases and sciences   Vol. 66 ( 7 ) page: 2291 - 2300   2021.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Endoscopic ultrasonography (EUS) and high-resolution manometry (HRM) can be used in the evaluation of eosinophilic esophagitis (EoE) for frequent symptoms such as dysphagia. However, the role of these examinations is not clear. AIMS: The aim of this study was to objectively evaluate the subjective symptoms of EoE patients with EUS and HRM. METHODS: Patients who had endoscopic findings indicative of EoE and matched the number of eosinophil infiltrates used as diagnostic criteria were recruited between September 2018 and August 2019. Evaluable subjects underwent EUS and HRM and completed the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. The esophageal wall thickness (evaluated with EUS) and HRM parameters between patients with and without symptoms were retrospectively compared. Symptomatic patients were re-examined using EUS and HRM 6 months after treatment. RESULTS: A total of 35 patients (29 males, median age of 49 years) were divided into symptomatic (20 patients) and asymptomatic groups (15 patients). The esophageal wall was thicker, and the distal contractile integral (DCI) values were higher in the symptomatic group (P < 0.001). In addition, DCI values were positively correlated with esophageal wall thickness. After treatment, the GSRS scores showed an improving trend for each item. Esophageal wall thickness and DCI values were significantly decreased (Ps < 0.001). CONCLUSIONS: Esophageal wall thickening and increased esophageal body pressure may be involved in subjective symptoms. In addition, treatment may reduce esophageal thickness and pressure along with improvement of subjective symptoms.

    DOI: 10.1007/s10620-020-06527-5

    Web of Science

    Scopus

    PubMed

  124. Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long‐term prognosis

    Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Tadashi Iida, Hiroyuki Tanaka, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Senju Hashimoto, Akihiro Itoh, Masatoshi Ishigami, Yoshiki Hirooka, Mitsuhiro Fujishiro

    Digestive Endoscopy   Vol. 33 ( 5 ) page: 858 - 869   2021.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/den.13881

    Web of Science

    Scopus

    PubMed

    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/den.13881

  125. Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus. International journal

    Koichi Muroi, Ryoji Miyahara, Kohei Funasaka, Kazuhiro Furukawa, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Takeshi Onoue, Hiroshi Arima, Yoshiki Hirooka, Mitsuhiro Fujishiro

    Digestion   Vol. 102 ( 4 ) page: 554 - 562   2021.6

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: Dysphagia is a common symptom that occurs in patients with diabetes mellitus (DM). There have been few prospective observational studies on esophageal motility disorders in DM using high-resolution manometry (HRM). This study aimed to clarify the characteristics of esophageal motility disorders using HRM in patients with dysphagia and compare them between DM and non-DM patients. METHODS: Patients with dysphagia were prospectively recruited between October 2018 and July 2019. Patients (n = 89) underwent esophagogastroduodenoscopy and HRM and completed the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. Manometry parameters and motility disorder classifications were compared between DM and non-DM patients. We also investigated the differences in clinical backgrounds and questionnaire scores among DM patients with normal and abnormal manometry results. RESULTS: A higher prevalence of esophageal motility disorder was observed in DM patients (60%, 21/35) compared to non-DM patients (29.6%, 16/54) (p = 0.001). The prevalence of minor disorders such as ineffective esophageal motor disorder and fragmented peristalsis was significantly higher (45 vs. 11%), and the distal contractile integral, integrated relaxation pressure, and contractile front velocity values were lower in the DM group. Among DM patients, those with abnormal esophageal motility had a significantly higher prevalence of neuropathy, retinopathy, and nephropathy, as well as higher reflux or constipation scores on the GSRS, than those with normal results. CONCLUSIONS: Among patients with dysphagia, the frequency of minor esophageal motility disorders was higher in DM patients than in non-DM patients. Abnormal esophageal motility related to poor esophageal clearance was associated with higher prevalence of diabetic complications.

    DOI: 10.1159/000510081

    Web of Science

    Scopus

    PubMed

  126. Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal Dissection. International journal

    Tomohiko Suzuki, Kazuhiro Furukawa, Kohei Funasaka, Eri Ishikawa, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Ryoji Miyahara, Mitsuhiro Fujishiro

    Digestion   Vol. 102 ( 4 ) page: 563 - 571   2021.6

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: Patients with esophageal squamous cell carcinoma (ESCC) have various comorbidities. Thus, it is necessary to determine the appropriateness of performing treatment based on the patient's general condition. AIM: This study aimed to clarify the prognostic predictors of ESCC indicated for endoscopic submucosal dissection (ESD). METHODS: This retrospective study enrolled 241 patients with superficial ESCC endoscopically diagnosed as ESD-indicated lesions at the Nagoya University Hospital between January 2007 and December 2017. We evaluated the 3- and 5-year overall survival (OS) rates and prognostic predictors, such as the Prognostic Nutritional Index (PNI), Charlson Comorbidity Index (CCI), Psoas Muscle Index, and Controlling Nutritional Status score. Furthermore, we created a score-based classification using the prognostic predictors identified by multivariate analysis, and the 3- and 5-year OS rates were compared among the calculated scores. RESULTS: In the multivariate analysis, PNI < 45 (hazard ratio [HR]: 2.39; 95% confidence interval [CI]: 1.28-4.46; p = 0.006) and CCI ≥ 3 (HR: 4.42; 95% CI: 2.40-8.12; p < 0.001) were significantly associated with the OS. Based on the HR, 0 and 1 were assigned to PNI and 0, 2, and 4 were assigned to CCI, and the score classification of 0-5 points was created. The 3- and 5-year OS rates in patients with a score 3 were significantly higher than in those with scores 4 and 5. As a result of scoring, the prognosis was stratified; the 3- and 5-year OS rates in patients with scores 4 and 5, that is, CCI ≥ 6, were clearly low, at approximately 10%. CONCLUSIONS: CCI and PNI can be prognostic predictors of patients with superficial ESCC indicated for ESD. Observation without ESD might be an acceptable strategy among patients with CCI ≥ 6.

    DOI: 10.1159/000510091

    Web of Science

    Scopus

    PubMed

  127. Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis. International journal

    Hiroyuki Tanaka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Tadashi Iida, Eri Ishikawa, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Yoshie Shimoyama, Ryoji Miyahara, Naoto Kawabe, Teiji Kuzuya, Senju Hashimoto, Masatoshi Ishigami, Yoshiki Hirooka, Mitsuhiro Fujishiro

    BMC gastroenterology   Vol. 21 ( 1 ) page: 224 - 224   2021.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Endoscopic papillectomy of duodenal papillary tumors (PT) is indicated for adenomas or well-differentiated adenocarcinomas that do not involve the sphincter of Oddi. However, there is currently no reliable pre-operative method to diagnose the infiltration in the sphincter of Oddi.' Insulin-like growth factor 2 mRNA protein 3 (IMP3) staining is reportedly associated with advanced disease stage and clinical outcomes in many carcinomas. The aim of this retrospective study was to investigate the ability of diagnosing sphincter of Oddi involvement in PT and predicting the prognoses using IMP3 immunohistochemistry. METHODS: Twenty-five resected specimens from patients with PT and 24 biopsy specimens from the same patients excluding one were immunostained for IMP3. The percentage of positive cells in the tumor was evaluated and compared with the final pathological diagnosis and prognosis. RESULTS: The final pathological diagnoses were adenoma in 5 patients and adenocarcinoma in 20 patients (no sphincter of Oddi involvement in 5 and involvement in 15). The ability to diagnose sphincter of Oddi involvement based on the percentage of IMP3-positive cells in resected specimens and tissue biopsies was the area under the curve 0.8 and 0.78, respectively, of the receiver operating characteristic curve, and the accuracies were 80.0% and 75.0% (cutoff value: 10%), respectively. Moreover, patients with an IMP3-positive cell rate of ≥ 10% had a significantly worse prognosis (log-rank test P = 0.01). CONCLUSION: IMP3 immunostaining of resected and biopsy specimens from PT patients enables the diagnosis of sphincter of Oddi involvement objectively and is also effective in predicting the prognosis.

    DOI: 10.1186/s12876-021-01811-8

    Web of Science

    Scopus

    PubMed

  128. Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency. International journal

    Kota Uetsuki, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Tadashi Iida, Kenta Yamamoto, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Masatoshi Ishigami, Yoshiki Hirooka, Mitsuhiro Fujishiro

    BMC gastroenterology   Vol. 21 ( 1 ) page: 211 - 211   2021.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Pancreatic exocrine insufficiency (PEI) is associated with the outcome of pancreatic disease. However, there is no method for assessing PEI that can be used noninvasively and easily for outpatient. It has been reported that changes in intestinal bacteria caused by PEI may increase breath hydrogen concentration (BHC) levels during glucose or lactose loading. We have evaluated the usefulness of fasting breath hydrogen concentration (FBHC) measurement without glucose loading for the evaluation of PEI. METHODS: Sixty patients underwent FBHC measurement, BT-PABA testing, and microbiome analysis. They were classified into PEI group (PABA excretion rate < 73.4%, n = 30) and non-PEI group (n = 30). The FBHC of the two groups were compared, and the diagnostic ability of PEI by them was evaluated. The 16 s rRNA (V3-V4) from fecal samples was analyzed by MiSeq. RESULTS: FBHC levels was higher in the PEI group 15.70 (1.4 to 77.0) ppm than in the non-PEI group 2.80 (0.7 to 28.2) ppm (P < 0.0001). FBHC was negatively correlated with PABA excretion rate (r =  - 0.523, P < 0.001). The cutoff value of FBHC of 10.7 ppm (95% CI: 0.678-0.913, P < 0.001) showed a sensitivity of 73.3% and specificity of 83.3% for PEI diagnosis. In the PEI group, there was a significant increase of relative abundance of phylum Firmicutes (P < 0.05) and the genus Clostridium (P < 0.05). CONCLUSION: FBHC shows good potential as a simple and repeatable test for the diagnosis of PEI. The elevated FBHC levels may be caused by hydrogen-producing bacteria such as Clostridium.

    DOI: 10.1186/s12876-021-01776-8

    Web of Science

    Scopus

    PubMed

  129. New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasms. International journal

    Masaya Esaki, Takeshi Yamamura, Masanao Nakamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Eri Ishikawa, Kazuhiro Furukawa, Hiroki Kawashima, Yoshiki Hirooka, Mitsuhiro Fujishiro

    International journal of colorectal disease   Vol. 36 ( 5 ) page: 919 - 927   2021.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    PURPOSE: Sound speed correction (SSC) is a non-invasive modality that quantifies the hardness of neoplasms. The aim of our study was to evaluate the usefulness of SSC for the diagnostic accuracy of colorectal neoplasms and to differentiate the depth of invasion. METHODS: Forty colorectal neoplasms, contributed by 40 patients, were included in the analysis. The primary outcome was the diagnostic ability of SSC for the depth of invasion of colorectal neoplasms, with the secondary endpoint being the clinical efficacy of SSC to distinguish between a neoplasm and normal mucosa. RESULTS: The median sound speeds for colorectal neoplasms and normal mucosa were 1580 m/s and 1515 m/s, respectively (p < 0.001), with a median sound speed of 1583 m/s for lesions with a depth shallower than that of the muscularis propria and 1610 m/s for depths deeper than that of the muscularis propria (p = 0.002). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 80.0%, 100%, 100%, 83.3%, 90.0%, and 100%, respectively, for the diagnosis of neoplasms (using a cut-off sound speed of 1557 m/s) and 100%, 77.8%, 33.3%, 100%, 80.0%, respectively, for the diagnosis of the depth of invasion (using a cut-off of 1590 m/s). CONCLUSION: We identified absolute sound speeds for colorectal neoplasms and the depth of invasion of neoplasms which yielded a good diagnostic performance. SSC provides an objective evaluation of colorectal neoplasms and the depth of invasion of neoplasms and, thus, might be a useful modality in practice. TRIAL REGISTRATION: UMIN000038235 , Date of registration; October 8, 2019.

    DOI: 10.1007/s00384-020-03790-w

    Web of Science

    Scopus

    PubMed

  130. Diagnostic performance of endoscopic ultrasonography-guided elastography for solid pancreatic lesions: Shear-wave measurements versus strain elastography with histogram analysis. International journal

    Eizaburo Ohno, Hiroki Kawashima, Takuya Ishikawa, Tadashi Iida, Hirotaka Suzuki, Kota Uetsuki, Jun Yashika, Kenta Yamada, Masakatsu Yoshikawa, Noriaki Gibo, Toshinori Aoki, Kunio Kataoka, Hiroshi Mori, Takeshi Yamamura, Kazuhiro Furukawa, Masanao Nakamura, Yoshiki Hirooka, Mitsuhiro Fujishiro

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 33 ( 4 ) page: 629 - 638   2021.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND AND AIMS: Endoscopic ultrasound (EUS) elastography (EUS-EG) is a minimally invasive diagnostic method for evaluating tissue elasticity. The aim of this study was to evaluate the feasibility of newly developed EUS shear-wave measurement (EUS-SWM) and to compare diagnostic performance between EUS-SWM and the conventional strain elastography (SE) for the measurement of elasticity of solid pancreatic lesions (SPLs). METHODS: From December 2017 until August 2019, we retrospectively reviewed 64 consecutive cases with SPLs who underwent both EUS-SWM and SE. EUS-SWM was used to measure the shear-wave velocity, Vs (m/s), and the unique measurement reliability index, VsN (%), in the target lesion. SE images were assessed by strain histogram (SH) analysis, and the mean strain value of the elasticity index was measured. We evaluated the diagnostic performance of EUS-SWM and SE with SH to characterize the SPLs. RESULTS: The Vs (m/s) values of SPLs were 2.19 for pancreatic cancer (PC), 1.31 for pancreatic neuroendocrine neoplasm (PanNEN), 2.56 for mass-forming pancreatitis (MFP) and 1.58 for metastatic tumors. Vs showed no significant difference based on the disease. The mean strain values were 45.5 for PC, 47.3 for PanNEN, and 74.5 for MFP. In the comparison of tissue elasticity between PC and MFP, Vs showed no significant difference (P = 0.5687); however, the mean strain value was significantly lower in PC cases (45.4 vs 74.5: P = 0.0007). CONCLUSION: Endoscopic ultrasound SWM tended to be unstable for the measurement of elasticity of SPLs, and conventional SE with SH was superior for their characterization.

    DOI: 10.1111/den.13791

    Web of Science

    Scopus

    PubMed

  131. Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice. International journal

    Takahiro Nishikawa, Keiko Maeda, Masanao Nakamura, Takeshi Yamamura, Tsunaki Sawada, Yasuyuki Mizutani, Takanori Ito, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Ryoji Miyahara, Hiroki Kawashima, Takashi Honda, Masatoshi Ishigami, Tokunori Yamamoto, Seiji Matsumoto, Yuji Hotta, Mitsuhiro Fujishiro

    Digestive diseases and sciences   Vol. 66 ( 4 ) page: 1034 - 1044   2021.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, persistent, and intractable enteritis; however, an effective treatment strategy is yet to be established. Mesenchymal stem cells (MSCs) and their paracrine factors exhibit anti-inflammatory actions and have been proposed as a new therapeutic candidate for IBD treatment, although the efficacy of MSC lysate on enteritis is unclear. AIMS: Here, we examined the efficacy and appropriate regimen of filtrated murine adipose-derived mesenchymal stem cell lysate (FADSTL) in an acute colitis mouse model as a novel cell-free MSC therapy. METHODS: To confirm the clinical effects of FADSTL, survival rate, body weight, and disease activity index (DAI) were investigated in the DSS-induced colitis mouse model. Further, differences in efficacy with dosing frequency were assessed to optimize the proper regimen. Colon length, histological findings, gene expression of inflammatory mediators and tight junction proteins in colon tissues, and anti-apoptotic effects were also compared in 3-day continuous FADSTL administration and PBS groups. RESULTS: Three-day continuous FADSTL administration significantly improved weight loss and DAI score compared to those in the PBS-treated group, whereas the effect was not observed with single administration. Additionally, colon shortening and histological inflammation were suppressed in the FADSTL-treated group. Further, this treatment decreased gene expression of inflammatory mediators, maintained expression of tight junction proteins in the colon, and showed anti-apoptotic effects. CONCLUSIONS: FADSTL effects were dependent on its administration frequency, suggesting the requirement of continuous FADSTL administration. FADSTL improved colitis by maintaining the intestinal barrier function through its anti-inflammatory and anti-apoptotic actions.

    DOI: 10.1007/s10620-020-06359-3

    Web of Science

    Scopus

    PubMed

  132. Endoscopic ultrasound elastography for small solid pancreatic lesions with or without main pancreatic duct dilatation. International journal

    Kunio Kataoka, Takuya Ishikawa, Eizaburo Ohno, Tadashi Iida, Hirotaka Suzuki, Kota Uetsuki, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Masatoshi Ishigami, Hiroki Kawashima, Yoshiki Hirooka, Mitsuhiro Fujishiro

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 21 ( 2 ) page: 451 - 458   2021.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: /Objectives: Endoscopic ultrasound elastography (EUS-EG) is useful for diagnosis of small solid pancreatic lesions (SPLs), particularly in excluding pancreatic cancer (PC), but its dependence on main pancreatic duct dilatation (MPDD) has not been examined. We aimed to investigate EUS-EG for diagnosis of small SPLs with and without MPDD. METHODS: Patients with pathologically diagnosed SPLs of ≤20 mm were included and retrospectively analyzed. Using the blue:green ratio, an EUS-EG image was classified as blue-dominant, equivalent, or green-dominant. Using multiple EUS-EG images per patient, a lesion with a greater number of blue-dominant than green-dominant images was classified as stiff, and the others as soft. EUS-EG images in random order were judged by three raters. Considering stiff SPLs as PC, diagnostic performance of EUS-EG was examined for SPLs with and without MPDD. RESULTS: Of 126 cases analyzed, 65 (52%) were diagnosed as PC, and 63 (50%) had MPDD. A total of 1077 EUS-EG images were examined (kappa coefficient = 0.783). Lesions were classified as stiff in 91 cases and soft in 35 (kappa coefficient = 0.932). The ratio of stiff to soft lesions was significantly higher in PC than in non-PC (62:3 vs. 29:32, P < 0.001). The sensitivity, specificity, and negative predictive value of a stiff lesion with vs. without MPDD for diagnosis of PC were 94%, 23%, and 50% vs. 100%, 60%, and 100%, respectively. CONCLUSIONS: Using the EUS-EG stiffness classification for small SPLs, PC can be excluded with high confidence and concordance for a soft lesion without MPDD.

    DOI: 10.1016/j.pan.2020.12.012

    Web of Science

    Scopus

    PubMed

  133. Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancer. International journal

    Jun Yashika, Eizaburo Ohno, Takuya Ishikawa, Tadashi Iida, Hirotaka Suzuki, Kota Uetsuki, Kenta Yamada, Masakatsu Yoshikawa, Noriaki Gibo, Yoshie Shimoyama, Eri Ishikawa, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Masatoshi Ishigami, Yoshiki Hirooka, Hiroki Kawashima, Mitsuhiro Fujishiro

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 21 ( 2 ) page: 390 - 396   2021.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) is reported as a high-risk factor for pancreatic cancer (PC) that includes IPMN-derived cancers (IPMC) and the development of invasive pancreatic ductal adenocarcinoma (PDAC) concomitant with IPMN. Since invasive IPMC and PDAC exhibit different oncological behaviors, their differentiation is clinically important. We aimed to investigate the use of contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) for the differential diagnosis between invasive IPMC and PDAC. METHODS: This study involved 183 consecutive patients with PC (invasive IPMC: 42, PDAC concomitant with IPMN: 9, without IPMN: 132) who underwent CEH-EUS preoperatively. While investigating the patterns, enhanced effects in the solid part of the tumor were compared with those in the surrounding pancreatic parenchyma after administration of Sonazoid® and evaluated as hyperenhanced, isoenhanced, or hypoenhanced. We retrospectively compared the enhanced pattern of CEH-EUS by using multiphasic analysis and clinicopathological factors between invasive IPMC and PDAC. RESULTS: In multiphase evaluations at 20, 40 and 60 s in CEH-EUS, 75.2% (106/141) of PDACs were hypoenhanced (-) at ≥2 of the 3 time points, with significant differences from those of invasive IPMC (P < 0.001). The solid tumor diameter was significantly larger in PDAC than in invasive IPMC, and the tumor stage and preoperative serum carbohydrate antigen 19-9 level were higher. After propensity score matching of stage and solid tumor diameter, contrast enhancement patterns were significantly more persistent in invasive IPMC than in PDAC (P = 0.0013). CONCLUSIONS: Multiphase evaluation using CEH-EUS is a useful method for differentiating between invasive IPMC and PDAC.

    DOI: 10.1016/j.pan.2020.12.022

    Web of Science

    Scopus

    PubMed

  134. Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesions. International journal

    Takuya Ishikawa, Hiroki Kawashima, Eizaburo Ohno, Tadashi Iida, Hirotaka Suzuki, Kota Uetsuki, Jun Yashika, Kenta Yamada, Masakatsu Yoshikawa, Noriaki Gibo, Toshinori Aoki, Kunio Kataoka, Hiroshi Mori, Takeshi Yamamura, Kazuhiro Furukawa, Masanao Nakamura, Yoshiki Hirooka, Mitsuhiro Fujishiro

    Scientific reports   Vol. 11 ( 1 ) page: 406 - 406   2021.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Autoimmune pancreatitis (AIP) is recognized as the pancreatic manifestation of a systemic IgG4-related disease that can involve various organs, including the kidney. However, renal lesions tend to be overlooked when AIP is diagnosed, and the clinical characteristics and long-term prognosis of AIP with renal lesions are unclear. We retrospectively reviewed 153 patients with AIP diagnosed at our hospital with a median follow-up period of 41 months (interquartile range, 10-86) and classified them into two groups: the KD group (n = 17), with characteristic renal imaging features, and the non-KD group (n = 136). Serum IgG4 levels were significantly higher in the KD group (663 vs. 304.5 mg/dl, P = 0.014). No differences were observed between the two groups in terms of steroid treatment [14/17 (82.4%) vs. 112/136 (82.4%), P = 1] or in the number of patients who exhibited exacerbation of renal function during treatment [1/17 (5.9%) vs. 8/136 (5.9%), P = 1]. However, the cumulative relapse rate was significantly higher in the KD group [61% vs. 21.9% (3 years), P < 0.001]. Patients in the KD group had different clinical features with high relapse rates compared with those in the non-KD group, and thus, it is important to confirm the presence of renal lesions in AIP patients.

    DOI: 10.1038/s41598-020-79899-3

    Web of Science

    Scopus

    PubMed

  135. Tag‐less patency capsule for suspected small bowel stenosis: Nationwide multicenter prospective study in Japan Reviewed

    Masanao Nakamura, Kenji Watanabe, Naoki Ohmiya, Fumihito Hirai, Teppei Omori, Daisuke Tokuhara, Konosuke Nakaji, Sadaharu Nouda, Motohiro Esaki, Yukinori Sameshima, Hidemi Goto, Akira Terano, Hisao Tajiri, Toshiyuki Matsui

    Digestive Endoscopy   Vol. 33 ( 1 ) page: 151 - 161   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/den.13673

    Scopus

    PubMed

    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/den.13673

  136. Collision Tumors of Gastric Adenocarcinoma and Mucosa-associated Lymphoid Tissue Lymphoma

    Kobayashi Kenichi, Furukawa Kazuhiro, Ishikawa Eri, Mitsuma Ayako, Funasaka Kohei, Kakushima Naomi, Furune Satoshi, Ito Nobuhito, Wada Hirotaka, Hirose Takashi, Muroi Koichi, Suzuki Tomohiko, Suzuki Takahiro, Hida Emiko, Hirai Keiko, Shibata Hiroyuki, Koya Toshinari, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Fujishiro Mitsuhiro

    Internal Medicine   Vol. 60 ( 15 ) page: 2419 - 2424   2021

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Internal Medicine  

    <p>A 65-year-old woman with a history of treatment for splenic marginal zone B-cell lymphoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma underwent esophagogastroduodenoscopy. A reddish elevated lesion was found in the fundus of the stomach. On image-enhanced endoscopy, several findings, such as glandular structures of varying sizes suggesting well-differentiated adenocarcinoma, pruned blood vessels, and dilated blood vessels in deeper mucosa suggesting MALT lymphoma, were observed. The final pathological diagnosis after surgical resection was collision tumors of well-differentiated adenocarcinoma and MALT lymphoma. The features of both tumors could be observed simultaneously with image-enhanced endoscopy. </p>

    DOI: 10.2169/internalmedicine.6124-20

    Web of Science

    Scopus

    PubMed

    CiNii Research

  137. The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease.

    Shun Hattori, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Kenta Yamamoto, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Takashi Honda, Hiroki Kawashima, Masatoshi Ishigami, Yoshiki Hirooka, Mitsuhiro Fujishiro

    Journal of gastroenterology   Vol. 55 ( 12 ) page: 1138 - 1149   2020.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Mucosal healing is the main treatment goal for Crohn's disease. In this situation, some patients have difficulty with endoscopic evaluation of the entire small intestine. Crohn's disease is closely associated with the gut microbiota, but the relationship between the microbiome and disease activity in the small intestine remains unclear. We examined the association between the microbiome and endoscopic findings in the small intestine and determined whether the microbiome can predict mucosal healing. METHODS: The patients with Crohn's disease who were scheduled for capsule or balloon-assisted endoscopy were included in this prospective study. Patients whose entire small intestine was evaluated were divided into two groups based on ulcerative findings. The microbiomes in the fecal samples were analyzed using 16S rRNA sequencing. RESULTS: The 38 enrolled patients were divided into the ulcer group (24) and mucosal healing group (14). The ulcer group exhibited lower α diversity. Six genera, namely Faecalibacterium (P = 0.008), Lachnospira (P = 0.009), Paraprevotella (P = 0.01), Dialister (P = 0.012), Streptococcus (P = 0.025), and Clostridium (P = 0.028) were enriched in the mucosal healing group. A predictive score for mucosal healing was defined using these six genera. The area under the curve was 0.795 and the sensitivity and specificity for predicting mucosal healing were 0.643 and 0.917, respectively. CONCLUSIONS: Fecal microbiome is corelated with disease activity in the entire small intestine in Crohn's disease patients. The predictive score proposed by microbiota characteristics was a potential biomarker for mucosal healing in the small intestine.

    DOI: 10.1007/s00535-020-01728-1

    Web of Science

    Scopus

    PubMed

  138. Mutation analysis of gastrointestinal stromal tumors using RNA obtained via endoscopic ultrasound-guided fine-needle aspiration. International journal

    Kohei Funasaka, Ryoji Miyahara, Kazuhiro Furukawa, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Yoshiki Hirooka, Naoki Ohmiya, Mitsuhiro Fujishiro

    Translational oncology   Vol. 13 ( 11 ) page: 100848 - 100848   2020.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) is useful for pathologically diagnosing gastrointestinal stromal tumor (GIST) before surgery. However, its role in mutation analysis remains unclear. To examine the feasibility of analyzing GIST mutations using mRNA obtained with EUS-FNA, we prospectively enrolled 41 patients with subepithelial lesion from which EUS-FNA was successfully acquired tissue sample. Thirty-two, 5, and 4 subepithelial lesions were diagnosed as GISTs, schwannomas, and leiomyomas, respectively. After RNA was extracted from FNA sample, RNA was converted to cDNA. Full-length sequence of the KIT cDNA amplified via the polymerase chain reaction (PCR) was successful in 31 (96.9%) out of 32 GIST and three out of 9 non-GIST (33.3%). The KIT mutation statuses of 31 GISTs in which KIT cDNA was amplified were successfully determined through directional sequencing. Furthermore, 15 of 16 surgically excised GISTs exhibited the same mutation status in both the EUS-FNA and resected samples. In vitro experiment, the minimum number of cells required to amplify full-length of KIT cDNA from RNA was one-tenth of that required to amplify KIT exon11 gene from DNA. This study clarifies that mutation analysis using RNA obtained with EUS-FNA is feasible and reliable. Moreover, our data would support that RNA-based mutation is superior to DNA-based mutation analysis in GIST.

    DOI: 10.1016/j.tranon.2020.100848

    Web of Science

    Scopus

    PubMed

  139. Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn’s Disease Patients Reviewed

    Kentaro Murate, Keiko Maeda, Masanao Nakamura, Daisuke Sugiyama, Hirotaka Wada, Takeshi Yamamura, Tsunaki Sawada, Yasuyuki Mizutani, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Takashi Honda, Hiroki Kawashima, Ryoji Miyahara, Masatoshi Ishigami, Hiroyoshi Nishikawa, Mitsuhiro Fujishiro

    Inflammatory Bowel Diseases   Vol. 26 ( 11 ) page: 1669 - 1681   2020.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    <title>Abstract</title>
    <sec>
    <title>Background and Aims</title>
    The therapeutic efficacy and safety of ustekinumab for Crohn’s disease (CD) have been reported from randomized controlled trials and real-world data. However, there are few studies describing the identification of patients most suitable for ustekinumab therapy. The aim of this study was to prospectively evaluate the patients receiving ustekinumab and identify predictors of the treatment efficacy.


    </sec>
    <sec>
    <title>Methods</title>
    Patients with moderate to severe active CD scheduled to receive ustekinumab were enrolled. The responders and nonresponders were compared at weeks 0, 8, 24, and 48 by evaluating patient demographics, simple endoscopic scores (SES-CD), ustekinumab and cytokine concentrations, and cellular fractions.


    </sec>
    <sec>
    <title>Results</title>
    The clinical response and clinical remission rates in the 22 enrolled patients were 59.1% and 31. 8% at week 8, 68.2% and 45.5% at week 24, and 54.4% and 40.9% at week 48, respectively. There were no significant differences in patients’ demographic and disease characteristics at baseline between responders and nonresponders. A combination of low SES-CD and high serum TNF-α concentration at baseline showed a good correlation with the clinical response. Serum TNF-α concentration was decreased because of the therapy. The ratio of CD4+TNF-α cells at baseline was significantly higher in responders than in nonresponders; however, the ratios of CD45+CD11b+TNF-α and CD45+CD11c+TNF-α cells were not different. The ratio of CD4+ TNF-α cells decreased with the treatment in the responders but not in the nonresponders.


    </sec>
    <sec>
    <title>Conclusions</title>
    The combination of 2 factors, namely higher serum TNF-α concentration and lower SES-CD at baseline, may assist clinicians in selecting the appropriate therapy for patients with moderate to severe CD.


    </sec>

    DOI: 10.1093/ibd/izaa086

    Web of Science

    Scopus

    PubMed

  140. What is the role of measuring shear wave dispersion using shear wave elastography in pancreatic parenchyma?

    Hirotaka Suzuki, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Senju Hashimoto, Masanao Nakamura, Ryoji Miyahara, Masatoshi Ishigami, Yoshiki Hirooka, Mitsuhiro Fujishiro

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 47 ( 4 ) page: 575 - 581   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER JAPAN KK  

    Purpose Shear wave elastography (SWE) using transabdominal ultrasonography (US) is widely used for diagnosis of tissue stiffness. Ultrasound shear wave dispersion (SWD) enables evaluation of tissue viscosity using SWE. The objective of this study was to investigate the reliability and clinical significance of SWD in pancreatic screening. Methods SWE and SWD were measured in 76 patients examined by US in pancreatic screenings performed between November 2017 and November 2018. The median pancreatic elastic modulus (PEM) and dispersion slope were obtained from at least five measurements. The reproducibility of these values and their correlations with patient characteristics, pancreatic echogenicity, and the pancreas-to-spleen attenuation ratio (P/S) on plain CT, which is associated with fatty change in pancreatic parenchyma, were investigated retrospectively. Results The median PEM and dispersion slope were 7.4 kPa and 15.7 (m/sec)/kHz, respectively, and both values had high intraclass correlation coefficients, showing high reproducibility (rho = 0.869 and rho = 0.867, respectively). The interquartile range/median value of PEM and dispersion slope were 0.36 and 0.28, respectively. PEM had a positive correlation with age (r(s) = 0.348,p = 0.002), and dispersion slope was positively correlated with age (r(s) = 0.278,p = 0.016) and BMI (r(s) = 0.397,p < 0.001). The hyperechoic pancreas had significantly higher PEM (6.6 vs. 7.8 kPa,p = 0.037) and dispersion slope (13.2 vs. 16.3 (m/sec)/kHz,p < 0.001). On plain CT performed in 50 patients, the P/S was not correlated with PEM (r(s) = - 0.180,p = 0.221), but was inversely correlated with dispersion slope (r(s) = - 0.338,p = 0.019). Conclusion Measurement of SWD in pancreatic screening was highly reproducible and may permit objective evaluation of fatty change of the pancreas.

    DOI: 10.1007/s10396-020-01033-7

    Web of Science

    Scopus

    PubMed

  141. Comparison of different virtual chromoendoscopy classification systems for the characterization of colorectal lesions. International journal

    Leonardo Zorron Cheng Tao Pu, Takeshi Yamamura, Masanao Nakamura, Doreen S C Koay, Amanda Ovenden, Suzanne Edwards, Alastair D Burt, Yoshiki Hirooka, Mitsuhiro Fujishiro, Rajvinder Singh

    JGH open : an open access journal of gastroenterology and hepatology   Vol. 4 ( 5 ) page: 818 - 826   2020.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Background and Aim: Commonly used classifications for colorectal lesions (CLs) include the Narrow Band Imaging (NBI) International Colorectal Endoscopic (NICE) and Japan NBI Expert Team (JNET) classifications. However, both lack a sessile serrated adenoma/polyp (SSA/P) category. This has been addressed by the modified Sano's (MS) and Workgroup serrAted polypS and Polyposis (WASP) classifications. This study aims to compare the accuracy of wNICE and wJNET (WASP added to both) with the stand-alone MS classification. Methods: Patients undergoing colonoscopy at an Australian tertiary hospital who had at least one CL detected were prospectively enrolled. In the exploratory phase, CLs were characterized in real time with NBI and magnification using all classifications. In the validation phase, CLs were assessed with both NBI and Blue Laser Imaging (BLI) by four external endoscopists in Japan. The primary outcome was the comparison of wJNET and MS. Secondary outcomes included comparisons among all classifications and the calculation of interrater reliability. Results: A total of 483 CLs were evaluated in real time in the exploratory phase, and four sets of 30 CL images (80 on NBI and 40 on BLI) were scored in the validation phase. For high-confidence diagnoses, MS accuracy was superior to wJNET in both the exploratory (86% vs 79%, P < 0.05) and validation (85% vs 69%, P < 0.05) phases. The interrater reliability was substantial for all classifications (κ = 0.74, 0.69, and 0.63 for wNICE, wJNET, and MS, respectively). Conclusions: MS classification achieved the highest accuracy in both the exploratory and validation phases. MS can differentiate serrated and adenomatous polyps as a stand-alone classification.

    DOI: 10.1002/jgh3.12382

    Web of Science

    Scopus

    PubMed

  142. Computer-aided diagnosis for characterization of colorectal lesions: comprehensive software that includes differentiation of serrated lesions. International journal

    Leonardo Zorron Cheng Tao Pu, Gabriel Maicas, Yu Tian, Takeshi Yamamura, Masanao Nakamura, Hiroto Suzuki, Gurfarmaan Singh, Khizar Rana, Yoshiki Hirooka, Alastair D Burt, Mitsuhiro Fujishiro, Gustavo Carneiro, Rajvinder Singh

    Gastrointestinal endoscopy   Vol. 92 ( 4 ) page: 891 - 899   2020.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND AND AIMS: Endoscopy guidelines recommend adhering to policies such as resect and discard only if the optical biopsy is accurate. However, accuracy in predicting histology can vary greatly. Computer-aided diagnosis (CAD) for characterization of colorectal lesions may help with this issue. In this study, CAD software developed at the University of Adelaide (Australia) that includes serrated polyp differentiation was validated with Japanese images on narrow-band imaging (NBI) and blue-laser imaging (BLI). METHODS: CAD software developed using machine learning and densely connected convolutional neural networks was modeled with NBI colorectal lesion images (Olympus 190 series - Australia) and validated for NBI (Olympus 290 series) and BLI (Fujifilm 700 series) with Japanese datasets. All images were correlated with histology according to the modified Sano classification. The CAD software was trained with Australian NBI images and tested with separate sets of images from Australia (NBI) and Japan (NBI and BLI). RESULTS: An Australian dataset of 1235 polyp images was used as training, testing, and internal validation sets. A Japanese dataset of 20 polyp images on NBI and 49 polyp images on BLI was used as external validation sets. The CAD software had a mean area under the curve (AUC) of 94.3% for the internal set and 84.5% and 90.3% for the external sets (NBI and BLI, respectively). CONCLUSIONS: The CAD achieved AUCs comparable with experts and similar results with NBI and BLI. Accurate CAD prediction was achievable, even when the predicted endoscopy imaging technology was not part of the training set.

    DOI: 10.1016/j.gie.2020.02.042

    Web of Science

    Scopus

    PubMed

  143. Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors. International journal

    Keiichi Sakamaki, Kohei Funasaka, Ryoji Miyahara, Kazuhiro Furukawa, Takeshi Yamamura, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Yoshiki Hirooka, Mitsuhiro Fujishiro, Hidemi Goto

    Scientific reports   Vol. 10 ( 1 ) page: 14767 - 14767   2020.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Although the majority of gastrointestinal stromal tumors (GISTs) possess KIT mutations that induce constitutive signal transduction, the clinical outcomes are variable. The ETS translocation variant 1 (ETV1) gene encodes a transcription factor that is reported to cooperate with KIT in GISTs. However, the clinical role of ETV1 is largely unknown. The aim of this study was to examine ETV1 expression and its associations with clinical features in GISTs. We conducted a cohort study involving 64 patients with GISTs who underwent surgical resection between October 2008 and February 2015. ETV1 mRNA expression was compared with that in non-GISTs and was analyzed among risk classifications or clinical outcomes. The GIST samples exhibited significantly higher ETV1 mRNA expression than the non-GIST samples (P < 0.0001). Sixty-four GISTs were stratified into high or low ETV1 mRNA expression groups based on the median relative abundance of ETV1 mRNA. The multivariate analysis showed that low ETV1 expression, as well as tumor size and mitotic index, was an independent factor of recurrence (hazard ratio: 8.1). Patients with high ETV1 expression achieved significantly longer recurrence-free survival (RFS) times than those with low ETV1 expression (P = 0.025). Our study revealed that low ETV1 expression is an independent factor of recurrence after surgery in patients with GISTs, and thus, low ETV1 expression might be a marker of more aggressive malignant GISTs.

    DOI: 10.1038/s41598-020-71719-y

    Web of Science

    Scopus

    PubMed

  144. Reappraisal of Primary Epstein-Barr Virus (EBV)-positive Diffuse Large B-Cell Lymphoma of the Gastrointestinal Tract: Comparative Analysis Among Immunosuppressed and Nonimmunosuppressed Stage I and II-IV Patients. Reviewed International journal

    Shouhei Miyagi, Eri Ishikawa, Masanao Nakamura, Kazuyuki Shimada, Takeshi Yamamura, Kazuhiro Furukawa, Tsutomu Tanaka, Seiyo Mabuchi, Yuta Tsuyuki, Kei Kohno, Ayako Sakakibara, Akira Satou, Seiichi Kato, Mitsuhiro Fujishiro, Shigeo Nakamura

    The American journal of surgical pathology   Vol. 44 ( 9 ) page: 1173 - 1183   2020.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoproliferation encompasses a broad range of clinicopathologic findings, including specific subtypes, for example, EBV mucocutaneous ulcer. Here we reassessed 36 cases of primary EBV diffuse large B-cell lymphomas (16 men and 20 women; median age, 69.5 y; range, 35 to 84 y), including 8 immunosuppressed patients (Lugano stage II-IV; median age, 74 y), 7 nonimmunosuppressed patients with stage I disease (median age, 69 y), and 21 nonimmunosuppressed patients with stage II-IV disease (median age, 69 y). All immunosuppressed patients exhibited iatrogenic immunodeficiency and an ulcerative appearance, with ulcer sites including the stomach (1 patient), small intestine (6 patients), and rectum (1 patient). Four patients were in the setting of treated lymphoma-associated immunosuppression. Immunosuppressed patients had higher incidences of intestinal involvement (P=0.001) and perforation (n=2) compared with advanced stage nonimmunosuppressed patients. Among nonimmunosuppressed stage I patients, lesions were restricted to the stomach, none showed multiple lesions or elevated serum lactate dehydrogenase, and the overall survival curve plateaued, although it was not statistically significant (P=0.0581). One nonimmunosuppressed stage I patient with a polypoid lesion exhibited spontaneous regression within 2 months after diagnosis, while another with bulky disease pursued an aggressive clinical course. Nonimmunosuppressed stage I cases without bulky masses may be considered EBV mucocutaneous ulcer with local progression. Our results demonstrated that primary EBV gastrointestinal diffuse large B-cell lymphoma could be delineated into 3 groups based on immune status and clinical stage, revealing distinguishing features useful as a pragmatic guide for diagnostic and therapeutic approaches.

    DOI: 10.1097/PAS.0000000000001499

    Web of Science

    Scopus

    PubMed

  145. Learning curve for mastery of colorectal endoscopic submucosal dissection: Perspectives from a large Japanese cohort. International journal

    Leonardo Zorron Cheng Tao Pu, Takeshi Yamamura, Masanao Nakamura, Masaya Esaki, Uayporn Kaosombatwattana, Miguel R Rodriguez, Suzanne Edwards, Alastair D Burt, Rajvinder Singh, Yoshiki Hirooka, Mitsuhiro Fujishiro

    JGH open : an open access journal of gastroenterology and hepatology   Vol. 4 ( 4 ) page: 611 - 616   2020.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Background and Aim: Endoscopic submucosal dissection (ESD) is a challenging procedure. A dissection speed of ≥9 cm2/h has been acknowledged as a mark for expertise, alongside a complication rate of ≤5% and en bloc resection rate of ≥90%. However, there is lack of objective information on whether the three measures correlate with each other. This study aims to evaluate the dissection speed, safety, and efficacy of colorectal ESDs performed by experts and trainees. Methods: Consecutive patients undergoing colorectal ESD at a Japanese hospital (2006-2017) were included in a prospectively collected database. Information on patient demographics, proceduralist, and intra-/postprocedure data was retrieved. The primary outcome was the comparison in dissection speed. The secondary outcomes included differences in safety and efficacy. Log-linear regression models adjusted for confounders (e.g. R0 resection) were used to assess the differences in dissection speed. Results: Five hundred ninety procedures (514 patients) performed by 26 endoscopists were analyzed. Experts performed a higher number of difficult lesions (e.g. F2 fibrosis) but achieved higher dissection speed (10.3 vs 6.7 cm2/h). The difference was statistically significant for both unadjusted and adjusted models (P < 0.0001). The en bloc resection rates were similar for both groups (experts = 95.6%; trainees = 94.7%, P = 0.61). Although nonexperts damaged more of the muscularis propria (18.6 vs 12.5%, P = 0.04), this did not translate into a significant difference in perforation (experts = 3.7%; trainees = 6.9%, P = 0.09) or delayed bleeding (experts = 2.9%; trainees = 4.4%, P = 0.34). The dissection speed steadily increased with expertise. Conclusion: Although dissection speed for colorectal ESD was significantly higher for experts, ESDs could be safely and efficaciously performed by ESD trainees.

    DOI: 10.1002/jgh3.12298

    Web of Science

    Scopus

    PubMed

  146. Polyp Detection Rate as a Surrogate for Adenoma and Sessile Serrated Adenoma/Polyp Detection Rates. International journal

    Leonardo Zorron Cheng Tao Pu, Gurfarmaan Singh, Khizar Rana, Masanao Nakamura, Takeshi Yamamura, Sudarshan Krishnamurthi, Amanda Ovenden, Suzanne Edwards, Andrew Ruszkiewicz, Yoshiki Hirooka, Mitsuhiro Fujishiro, Alastair D Burt, Rajvinder Singh

    Gastrointestinal tumors   Vol. 7 ( 3 ) page: 74 - 82   2020.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Introduction: Quality measures for colonoscopy such as adenoma detection rate (ADR) have been proposed to be surveilled for ensuring minimum standards. However, its direct measurement is time consuming and often neglected. Extrapolating ADR and other quality measures from polyp detection rate (PDR) can be a pragmatic alternative. Objective: To determine quotients for estimating ADR and sessile serrated adenoma/polyp detection rate (SSA/P-DR) from PDR in an Australian cohort. Methods: Consecutive adult patient colonoscopies during a 1-year period were retrospectively assessed in a single Australian tertiary endoscopy center. Adenoma detection quotient (ADQ) and SSA/P detection quotient (SSA/P-DQ) were defined as the division of ADR and SSA/P-DR by PDR, respectively. The primary outcome was the number of procedures to achieve a stable cumulative ADQ and SSA/P-DQ. Secondary outcomes included evaluation of ADQ and SSA/P-DQ in different subsets. Results: In total, 2,657 colonoscopies were performed by 15 endoscopists in 2016. The ADR, SSA/P-DR, and PDR found were 32.2, 6.7, and 47.3%, respectively. The ADQ and SSA/P-DQ values found were 0.68 and 0.14, respectively. After approximately 500 procedures, both ADQ and SSA/P-DQ became stable. Interclass correlation coefficient (ICC) for the prediction of ADR from ADQ was excellent for all endoscopists that performed >177 procedures in that year (ICC 0.84). Conclusions: ADQ and SSA/P-DQ values were consistent when over 500 procedures were analyzed. ADQ had an excellent correlation with ADR when >177 procedures per endoscopist were evaluated.

    DOI: 10.1159/000505622

    Web of Science

    PubMed

  147. Use of Immunostaining for the diagnosis of Lymphovascular invasion in superficial Barrett's esophageal adenocarcinoma. International journal

    Isao Hosono, Ryoji Miyahara, Kazuhiro Furukawa, Kohei Funasaka, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Takio Yokoi, Tetsuya Tsukamoto, Yoshiki Hirooka, Mitsuhiro Fujishiro

    BMC gastroenterology   Vol. 20 ( 1 ) page: 175 - 175   2020.6

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: The prevalence of Barrett's esophageal adenocarcinoma (BEA) is increasing in Japan. Accurate assessment of lymphovascular invasion (LVI) after endoscopic resection or surgery is essential in evaluating treatment response. This study aimed to assess the usefulness of immunostaining in determining the extent of LVI in superficial BEA. METHODS: We retrospectively included 41 patients who underwent endoscopic resection or surgery between January 2007 and July 2018. In all cases, 3-μm serial sections from paraffin-embedded resected specimens were used for hematoxylin and eosin (H-E) staining and immunostaining for D2-40 and CD31. Two specialized gastrointestinal pathologists (T.Y. and T.T.), blinded to clinical information, independently evaluated the extent of LVI from these specimens. The LVI-positivity rate was evaluated with respect to the depth of invasion, changes in the positivity rate on immunostaining, pathological characteristics of patients with LVI, lymph node metastasis or relapse, and course after treatment. RESULTS: H-E staining alone identified LVI in 7 patients (positivity rate: 17.1%). Depths of invasion were categorized based on extension to the submucosa (SM) or deeper. On immunostaining for D2-40 and CD31, additional positivity was detected in 2 patients with SM1 and 1 SM3, respectively; LVI was detected in 10 patients (positivity rate: 24.4%). LVI-positivity rates with invasion of the superficial muscularis mucosa (SMM)/lamina propria mucosa (LPM)/deep muscularis mucosa (DMM), SM 1, 2, and 3 were 0, 75, 28.6, and 55.6%, respectively. CONCLUSIONS: Combined H-E staining and immunostaining is useful in diagnosing LVI in superficial BEA, particularly in endoscopically resected specimens.

    DOI: 10.1186/s12876-020-01319-7

    Web of Science

    Scopus

    PubMed

  148. PROSPECTIVE MULTICENTER STUDY ON THE USEFULNESS OF EUS-GUIDED FINE NEEDLE BIOPSY FOR THE DIAGNOSIS OF AUTOIMMUNE PANCREATITIS USING A 22-GAUGE FRANSEEN NEEDLE

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yashika Jun, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Keiko Maeda, Sawada Tsunaki, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   Vol. 91 ( 6 ) page: AB172 - AB172   2020.6

     More details

  149. NOVEL METHOD TO DETERMINE THE DEPTH OF INVASION IN COLORECTAL NEOPLASMS WITH ULTRASOUND ELASTOGRAPHY USING A FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE

    Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Keiko Maeda, Sawada Tsunaki, Mizutani Yasuyuki, Kuno Takeshi, Yamada Kentaro, Hasegawa Issei, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   Vol. 91 ( 6 ) page: AB430 - AB430   2020.6

     More details

  150. ENDOSCOPIC DIAGNOSIS USING MAGNIFYING IMAGE-ENHANCED ENDOSCOPY FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMORS

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Sawada Tsunaki, Keiko Maeda, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   Vol. 91 ( 6 ) page: AB618 - AB618   2020.6

     More details

  151. EVALUATION OF RESECTABILITY BETWEEN ENDOSCOPIC TREATMENT METHODS FOR RECTAL NEUROENDOCRINE TUMOR

    Toriyama Kazuhiro, Yamamura Takeshi, Nakamura Masanao, Keiko Maeda, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   Vol. 91 ( 6 ) page: AB101 - AB101   2020.6

     More details

  152. Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy. International journal

    Keisaku Yamada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Ryoji Miyahara, Hiroki Kawashima, Naoki Hotta, Yoshiki Hirooka

    Digestion   Vol. 101 ( 3 ) page: 316 - 322   2020.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: There are a number of reports that demonstrate the high diagnostic accuracy of colon capsule endoscopy (CCE) for polyp detection. However, some colorectal polyps are missed on CCE, and the clinical factors influencing those missed polyps are still unknown. OBJECTIVE: The aim of this study was to elucidate the clinical factors related to missing colorectal polyp on CCE by using per-polyp analysis. METHODS: We performed a retrospective multi-center study of 53 consecutive patients who underwent both CCE and colonoscopy (CS) within 3 months from January 2014 to -December 2017. Of those patients, we analyzed 151 polyps detected on CCE, and 149 polyps detected on CS diagnosed as neoplasm according to histopathological result. RESULTS: The capsule excretion rate was 81%. One hundred three polyps were detected on both CS and CCE, 46 polyps (31%) were missed on CCE, and 48 polyps were considered false positive on CCE when CS result was considered as the gold standard. Per-polyp sensitivity and positive predictive value on CCE were 69.1 and 68%. On multiple logistic analysis, only the segmental transit time on CCE was identified as the independent factor influencing missed polyp on CCE. CONCLUSIONS: The clinical factor related to missing colorectal polyp on CCE was the segmental transit time.

    DOI: 10.1159/000498942

    Web of Science

    Scopus

    PubMed

  153. Different factors are associated with conventional adenoma and serrated colorectal neoplasia.

    Leonardo Zorron Cheng Tao Pu, Khizar Rana, Gurfarmaan Singh, Masanao Nakamura, Takeshi Yamamura, Doreen Siew Ching Koay, Amanda Ovenden, Suzanne Edwards, Andrew Ruszkiewicz, Yoshiki Hirooka, Mitsuhiro Fujishiro, Alastair D Burt, Rajvinder Singh

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 335 - 343   2020.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Current data shows there are differences in factors associated with colorectal neoplasia based on geographical location and cultural settings. There are no studies focusing on the association between environmental factors and colorectal polyps in Australia. The aim of this study was to prospectively evaluate the association of various factors with different colorectal neoplasia histology. We utilized a simplified one-page questionnaire for patients undergoing colonoscopy for information on age; gender; comorbidities; family history of colorectal cancer; physical activity; smoking; diet; alcohol intake; and body mass index. Factors were then evaluated for association with the presence of: (1) neoplastic lesions; (2) conventional adenomas; (3) neoplastic serrated polyps; (4) any lesions (past and present); and (5) hyperplastic polyps. 291 procedures and 260 patients were included. Factors with a p-value < 0.2 in a univariate regression were included in an initial multivariable regression model. Backwards elimination was then performed, removing one predictor at a time until only significant predictors remained. In the final multivariable model, age≥65, male gender, type-2 diabetes mellitus, active smoking and family history of colorectal cancer were found to be statistically significant predictors for the presence of colorectal neoplasia. However, the significant predictors found for conventional adenomas (older age, male gender and smoking) were different from the significant predictors for neoplastic serrated polyps (type-2 diabetes mellitus and family history of colorectal cancer). Older age, male gender, type-2 diabetes mellitus, and smoking were significantly associated with the presence of colorectal neoplasia. The factors associated with conventional adenomas differed from those associated with neoplastic serrated polyps.

    DOI: 10.18999/nagjms.82.2.335

    Web of Science

    Scopus

    PubMed

  154. Narrow-band imaging for scar (NBI-SCAR) classification: from conception to multicenter validation. International journal

    Leonardo Zorron Cheng Tao Pu, Keng Hoong Chiam, Takeshi Yamamura, Masanao Nakamura, Tyler M Berzin, Fahad F Mir, Eduardo Guimarães Hourneaux de Moura, Antonio Coutinho Madruga Neto, Doreen Siew Ching Koay, Cheong Kuan Loong, Amanda Ovenden, Suzanne Edwards, Alastair D Burt, Yoshiki Hirooka, Mitsuhiro Fujishiro, Rajvinder Singh

    Gastrointestinal endoscopy   Vol. 91 ( 5 ) page: 1146 - +   2020.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND AND AIMS: Surveillance post-endoscopic resection (ER) currently warrants biopsy samples from the resection site scar in most cases, although clinical practice is variable. A classification with standard criteria for scars has not yet been established. We aimed to create and validate a novel classification for post-ER scars by using specific criteria based on advanced imaging. METHODS: Key endoscopic features for scars with and without recurrence were (1) dark brown color, elongated/branched pit pattern, and dense capillary pattern and (2) whitish, pale appearance, round/slightly large pits, and irregular sparse vessels. Scars were first assessed with high-definition white-light endoscopy (HD-WLE) followed by interrogation with narrow-band imaging (NBI). Scars with at least 2 concordant characteristics were diagnosed with "high confidence" for NBI for scar (NBI-SCAR) classification. The final endoscopic predictions were correlated with histopathology. The primary outcome was the difference in sensitivity between NBI-SCAR and HD-WLE predictions. Secondary outcomes included the validation of our findings in 6 different endoscopy settings (Australia, United States, Japan, Brazil, Singapore, and Malaysia). The validation took place in 2 sessions separated by 2 to 3 weeks, each with 10 one-minute videos of post-ER scars on underwater NBI with dual focus. Inter-rater and intrarater reliability were calculated with Fleiss' free-marginal kappa and Bennett et al. S score, respectively. RESULTS: One hundred scars from 82 patients were included. Ninety-five scars were accurately predicted with high confidence by NBI-SCAR in the exploratory phase. NBI-SCAR sensitivity was significantly higher compared with HD-WLE (100% vs 73.7%, P < .05). In the validation phase, similar results were found for endoscopists who routinely perform colonoscopies and use NBI (sensitivity of 96.4%). The inter-rater and intrarater reliability throughout all centers were, respectively, substantial (κ = .61) and moderate (average S = .52) for this subset. CONCLUSIONS: NBI-SCAR has a high sensitivity and negative predictive value for excluding recurrence for endoscopists experienced in colonoscopy and NBI. In this setting, this approach may help to accurately evaluate or resect scars and potentially mitigate the burden of unnecessary biopsy samples.

    DOI: 10.1016/j.gie.2019.08.036

    Web of Science

    Scopus

    PubMed

  155. Diagnosis of vascular invasion in pancreatic ductal adenocarcinoma using endoscopic ultrasound elastography. International journal

    Kenta Yamada, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroyuki Tanaka, Masanao Nakamura, Ryoji Miyahara, Masatoshi Ishigami, Yoshiki Hirooka, Mitsuhiro Fujishiro

    BMC gastroenterology   Vol. 20 ( 1 ) page: 81 - 81   2020.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Vascular invasion is an important criterion for resectability and deciding the therapeutic strategy for pancreatic ductal adenocarcinoma (PDAC), but imaging diagnosis is currently difficult. Endoscopic ultrasound (EUS) elastography (EG) images have band-like artifacts on the border between tumor and vessel due to different movement if the tumor is not connected to the vessel, i.e., no invasion. Based on this phenomenon, we assessed the usefulness of EUS-EG in the diagnosis of vascular invasion in PDAC. METHODS: The subjects were 44 out of 313 patients with PDAC who underwent EUS between January 2015 and November 2018, followed by surgery, no chemotherapy or radiotherapy, and pathological evaluation. Diagnostic accuracies of vascular invasion using dynamic computed tomography (CT), EUS B-mode and EUS-EG were compared with histopathological diagnosis. RESULTS: In 44 subjects (48 sites) who underwent both dynamic CT and EUS-B mode, the sensitivity, specificity and accuracy were 0.733, 0.697 and 0.708 on dynamic CT (48 sites); 0.733, 0.606 and 0.646 in EUS B-mode (48 sites); and 0.917, 0.900 and 0.906 in EUS-EG (32 sites). In 27 subjects (29 sites) with a tumor contacting a vessel with no vascular obstruction or stenosis on dynamic CT, the sensitivity, specificity and accuracy were 0.556, 0.750 and 0.690 on dynamic CT; 0.667, 0.700 and 0.690 in EUS B-mode; and 0.889, 0.850 and 0.862 in EUS-EG. CONCLUSIONS: These results suggest that EUS combined with EG improves diagnostic performance of vascular invasion in PDAC, especially in cases of which vascular invasion cannot be clearly assessed by dynamic CT.

    DOI: 10.1186/s12876-020-01228-9

    Web of Science

    Scopus

    PubMed

  156. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study. International journal

    Ryo Nishio, Hiroki Kawashima, Masanao Nakamura, Eizaburo Ohno, Takuya Ishikawa, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Hiroyuki Tanaka, Daisuke Sakai, Ryoji Miyahara, Masatoshi Ishigami, Yoshiki Hirooka, Mitsuhiro Fujishiro

    World journal of gastroenterology   Vol. 26 ( 10 ) page: 1056 - 1066   2020.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Double-balloon endoscopic retrograde cholangiography (DB-ERC) is widely performed for biliary diseases after reconstruction in gastrointestinal surgery, but there are few reports on DB-ERC after hepatectomy or living donor liver transplantation (LDLT). AIM: To examine the success rates and safety of DB-ERC after hepatectomy or LDLT. METHODS: The study was performed retrospectively in 26 patients (45 procedures) who underwent hepatectomy or LDLT (liver operation: LO group) and 40 control patients (59 procedures) who underwent pancreatoduodenectomy (control group). The technical success (endoscope reaching the choledochojejunostomy site), diagnostic success (performance of cholangiography), therapeutic success (completed interventions) and overall success rates, insertion and procedure (completion of DB-ERC) time, and adverse events were compared between these groups. RESULTS: There were no significant differences between LO and control groups in the technical [93.3% (42/45) vs 96.6% (57/59), P = 0.439], diagnostic [83.3% (35/42) vs 83.6% (46/55), P = 0.968], therapeutic [97.0% (32/33) vs 97.7% (43/44), P = 0.836], and overall [75.6% (34/45) vs 79.7% (47/59), P = 0.617] success rates. The median insertion time (22 vs 14 min, P < 0.001) and procedure time (43.5 vs 30 min, P = 0.033) were significantly longer in the LO group. The incidence of adverse events showed no significant difference [11.1% (5/45) vs 6.8% (4/59), P = 0.670]. CONCLUSION: DB-ERC after liver operation is safe and useful but longer time is required, so should be performed with particular care.

    DOI: 10.3748/wjg.v26.i10.1056

    Web of Science

    Scopus

    PubMed

  157. Microbiota profile is different for early and invasive colorectal cancer and is consistent throughout the colon. Reviewed

    Zorron Cheng Tao Pu L, Yamamoto K, Honda T, Nakamura M, Yamamura T, Hattori S, Burt AD, Singh R, Hirooka Y, Fujishiro M

    Journal of gastroenterology and hepatology   Vol. 35 ( 3 ) page: 433 - 437   2020.3

     More details

  158. Usefulness of Endoscopic Ultrasound Elastography Combined With the Strain Ratio in the Estimation of Treatment Effect in Autoimmune Pancreatitis. International journal

    Takuya Ishikawa, Hiroki Kawashima, Eizaburo Ohno, Hiroyuki Tanaka, Keiko Maeda, Tsunaki Sawada, Takeshi Yamamura, Kazuhiro Furukawa, Masanao Nakamura, Ryoji Miyahara, Masatoshi Ishigami, Mitsuhiro Fujishiro

    Pancreas   Vol. 49 ( 2 ) page: E21 - E22   2020.2

     More details

  159. Relationship Between Adverse Events and Microbiomes in Advanced Hepatocellular Carcinoma Patients Treated With Sorafenib. International journal

    Kenta Yamamoto, Teiji Kuzuya, Takashi Honda, Takanori Ito, Yoji Ishizu, Masanao Nakamura, Ryoji Miyahara, Hiroki Kawashima, Masatoshi Ishigami, Mitsuhiro Fujishiro

    Anticancer research   Vol. 40 ( 2 ) page: 665 - 676   2020.2

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND/AIM: Sorafenib results in several adverse events, the mechanism and predictors of which are unknown. Recently, it was reported that metabolism by microbiome changes the structure and effects of drugs. The blood levels of sorafenib may be affected by enterohepatic recycling of sorafenib due to microbial enzymes in the gut. We evaluated the relationship between adverse events caused by sorafenib treatment and microbiome in patients with advanced hepatocellular carcinoma. MATERIALS AND METHODS: Twenty-five patients were classified into two groups based on the presence of hand-foot syndrome (HFS) or diarrhea within 12 weeks post-sorafenib treatment. Before sorafenib treatment, the fecal samples were analyzed targeting the V3-V4 region of 16s ribosomal RNA. Microbiome and predicted functional gene were compared between two groups. RESULTS: The non-HFS group had a richer abundance of Veillonella, Bacillus, Enterobacter, Faecalibacterium, Lachnospira, Dialister, and Anaerostipes than the HFS group at genus level. Carotenoid biosynthesis and bacterial invasion of epithelial cells were enriched in the HFS group. The former three bacteria are classified as oral-origin bacteria, and the two predicted functions are associated with dysbiosis. The non-diarrhea group had a higher abundance of Butyricimonas and a lower abundance of Citrobacter, Peptostreptococcus, and Staphylococcaceae than the diarrhea group. Eight categories of predicted functional genes were detected with differences between the two groups. CONCLUSION: The non-HFS group had a higher relative abundance of oral-origin bacteria, which likely led to more robust dysbiosis in the gut. This dysbiosis may affect enterohepatic recycling. Additionally, the metabolism of these short-chain fatty acids in the gut may be different between the diarrhea and non-diarrhea groups.

    DOI: 10.21873/anticanres.13996

    Web of Science

    Scopus

    PubMed

  160. Generation of magnifying endoscopic images of gastric neoplasms based on an all-in-focus algorithm. International journal

    Kenichi Matsui, Kohei Funasaka, Ryoji Miyahara, Kazuhiro Furukawa, Masanobu Matsushita, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Osamu Watanabe, Kenichi Ohara, Yoshiki Hirooka, Hidemi Goto

    Journal of gastroenterology and hepatology   Vol. 35 ( 1 ) page: 65 - 70   2020.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND AND AIM: Magnifying endoscopy is useful for diagnosis of early gastrointestinal neoplasms by visualizing microvascular (MV) and microsurface (MS) structures of the mucosa when combined with image-enhanced endoscopy. However, precise control of the endoscope is needed because the depth of focus is narrow and the target may move. These problems may be overcome by the all-in-focus (AIF) technique, which was developed in the engineering field. The aim of the study was to evaluate magnifying endoscopic image with AIF algorithm. METHODS: Twenty gastric neoplasms were examined. Images were acquired at 80× magnification and converted to endoscopic images with an AIF algorithm (EI-AIF). The focus area and MV and MS patterns in the original image and the EI-AIF were compared on a 5-point Likert scale, where 5 indicates that the EI-AIF was superior. Intraclass correlation coefficients (ICCs) were used to assess the inter-evaluator reliability. An image quality measurement value was calculated for each image as an indicator of the degree of focus. RESULTS: The scores for focus area, MV, and MS were 4.78 ± 0.45 (ICC = 0.63), 4.12 ± 0.76 (ICC = 0.70), and 4.72 ± 0.52 (ICC = 0.45), respectively, with the EI-AIF significantly superior for all three items (P < 0.05 by Student's t-test). ICCs for the focus area and MV were > 0.60, indicating strong inter-evaluator reliability. Image quality measurement was higher for the EI-AIF compared with the original image in every case. CONCLUSIONS: Endoscopic observation with AIF algorithm gives a better image quality that allows easier evaluation of MV and MS patterns. This technique may resolve the difficulties with magnifying endoscopic observation.

    DOI: 10.1111/jgh.14792

    Web of Science

    Scopus

    PubMed

  161. Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma. Reviewed

    Kobayashi K, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Nakaguro M, Okumura Y, Hirooka Y, Fujishiro M

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 32 ( 1 ) page: 65 - 73   2020.1

     More details

  162. Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma. Reviewed

    Ishikawa E, Nakamura M, Shimada K, Tanaka T, Satou A, Kohno K, Sakakibara A, Furukawa K, Yamamura T, Miyahara R, Nakamura S, Kato S, Fujishiro M

    Journal of gastroenterology   Vol. 55 ( 1 ) page: 39 - 50   2020.1

     More details

  163. Nasal patency as a factor for successful transnasal endoscopy.

    Toshihiko Nagaya, Ryoji Miyahara, Kohei Funasaka, Kazuhiro Furukawa, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Tsutomu Nakashima, Seiichi Nakata, Yoshiki Hirooka

    Nagoya journal of medical science   Vol. 81 ( 4 ) page: 587 - 595   2019.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    In recent years, transnasal endoscopy had been more widely accepted for its safety and convenience, and although it can lead to a weaker pharyngeal reflex, compared with the effects of transoral endoscopy, examinees often suffer intolerable pain and discomfort during passage of the endoscope through the nasal cavity. The aim of this study was to estimate the relationship between the uncomfortable factors during transnasal endoscopy and nasal patency. The subjects comprised 23 consecutive patients who underwent transnasal endoscopy from October 2007 to April 2009 at our Gastroenterology and Otorhinolaryngology Departments. Immediately prior to endoscopy, the left and right nasal resistance was measured with an active anterior rhinomanometer; a value of 100 Pa was determined as nasal resistance. The transnasal endoscope was inserted in the subjectively preferred side by the examinee. Thereafter, the subjects were asked to fill in a questionnaire on physical tolerance during the procedure, to quantify the sensations of nasal pain, nausea, and choking on a 10-point visual analogue scale. The mean scores were 3.0 ± 2.7 for nasal pain, 1.7 ± 2.0 for choking, and 1.6 ± 1.9 for nausea. The most intolerable factor among the complaints was pain (45%), which was followed by nausea (18%) and choking (9%). Unilateral nasal resistance was significantly related with nasal pain only (P = 0.0135). In conclusion, the most difficult problem during transnasal endoscopy was pain, which was related to nasal patency. We successfully demonstrated the clinical significance of nasal patency in determining the side of insertion for transnasal endoscopy.

    DOI: 10.18999/nagjms.81.4.587

    Web of Science

    Scopus

    PubMed

  164. Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study.

    Eizaburo Ohno, Yoshiki Hirooka, Hiroki Kawashima, Takuya Ishikawa, Hiroyuki Tanaka, Daisuke Sakai, Yoji Ishizu, Teiji Kuzuya, Masanao Nakamura, Takashi Honda

    Journal of medical ultrasonics (2001)   Vol. 46 ( 4 ) page: 425 - 433   2019.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    PURPOSE: To assess the feasibility and the clinical usefulness of a newly developed endoscopic ultrasonography (EUS) shear-wave elastography technique (EUS shear-wave measurement: EUS-SWM) in the diagnosis and treatment of autoimmune pancreatitis (AIP). METHODS: Tissue elasticity was measured in the pancreas in 160 patients. The success rate of EUS-SWMs, the velocity of the shear wave (Vs, m/s), and the reliability index of the Vs measurement (VsN) were evaluated, and the elasticity (median Vs) was compared between AIP patients (n = 14) and normal controls. RESULTS: A total of 3837 EUS-SWMs were performed without adverse events. Overall, 97.6% (3743/3837) were successful. The median VsN was 74%. The median Vs values of the pancreas were as follows: 2.22 m/s in the pancreatic head (push position), 2.36 m/s in the head (pull position), 1.99 m/s in the body, and 2.25 m/s in the tail. The median Vs of the AIP group (2.57 m/s) was significantly higher than that of the normal controls (1.89 m/s) (P = 0.0185). The mean Vs significantly decreased from 3.32 m/s to 2.46 m/s after steroid therapy (n = 6) (P = 0.0234). CONCLUSION: EUS-SWM is feasible and generates credible results. EUS-SWM was a useful method for assessment of the effect of steroid therapy in AIP patients.

    DOI: 10.1007/s10396-019-00944-4

    Web of Science

    Scopus

    PubMed

  165. Specific members of gut microbiota predict mucosal healing in Crohn's disease

    Hattori S., Nakamura M., Yamamura T., Maeda K., Sawada T., Mizutani Y., Yamamoto K., Pu L. Zorron Cheng Tao, Honda T., Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 34   page: 152 - 152   2019.9

     More details

  166. Objective evaluation of the therapeutic effect of ustekinumab on Crohn's disease

    Yamamura T., Nakamura M., Murate K., Maeda K., Sawada T., Mizutani Y., Nishikawa T., Hattori S., Yamamoto K., Pu L. Zorron Cheng Tao, Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 34   page: 145 - 145   2019.9

     More details

  167. The Propagation Display Method Improves the Reproducibility of Pancreatic Shear Wave Elastography. International journal

    Kiyotaka Hashizume, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Manabu Kawai, Hiroki Suhara, Tomoaki Takeyama, Toshinari Koya, Hiroyuki Tanaka, Daisuke Sakai, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Takamichi Kuwahara, Senju Hashimoto, Hidemi Goto

    Ultrasound in medicine & biology   Vol. 45 ( 8 ) page: 2242 - 2247   2019.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Evaluation of the pancreatic elastic modulus (PEM) using shear wave elastography (SWE) requires at least 5 measurements to ensure reproducibility. The aim of this study was to evaluate improvement in reproducibility of SWE, using the propagation display method in normal pancreas ([NP] phase 1) and to examine the differences in PEM between NP and chronic pancreatitis (CP), intraductal papillary mucinous neoplasm (IPMN) and autoimmune pancreatitis ([AIP] phase 2). In phase 1, the measurement success rate, median PEM in repeated measurements and appropriate number of SWE measurements were determined in 109 cases with NP. In phase 2, PEM was measured in CP (n = 10), IPMN (n = 31) and AIP (n = 5), using the required number of SWE measurements determined in phase 1. In phase 1, the measurement success rate was 93.9% (92/109 cases). The median PEM for NP was 14.6 kPa and the appropriate number of SWE measurements was at least 3. In phase 2, the median PEMs in CP, IPMN and AIP were 19.6, 18.1 and 17.2 kPa, respectively, with significant differences between NP and CP (p = 0.0133) and between NP and IPMN (p = 0.0436). Use of the propagation display method in SWE improves the reproducibility of measurement of PEM.

    DOI: 10.1016/j.ultrasmedbio.2019.04.003

    Web of Science

    Scopus

    PubMed

  168. Comparison of 8- and 10-mm diameter fully covered self-expandable metal stents: A multicenter prospective study in patients with distal malignant biliary obstruction. International journal

    Hiroki Kawashima, Senju Hashimoto, Eizaburo Ohno, Takuya Ishikawa, Tomomasa Morishima, Hiroshi Matsubara, Hiroyuki Sugimoto, Koji Nonogaki, Akira Kanamori, Kazuo Hara, Takamichi Kuwahara, Masanao Nakamura, Ryoji Miyahara, Masatoshi Ishigami, Masahiko Ando, Yoshiki Hirooka

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 31 ( 4 ) page: 439 - 447   2019.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: The time to recurrent biliary obstruction (TRBO) of unresectable distal malignant biliary obstruction is generally thought to be longer when a self-expandable metal stent (SEMS) with a thicker inner diameter is used for drainage, but the dependence on the inner diameter using a fully covered SEMS (FCSEMS) is uncertain. The objective of this multicenter prospective study was to compare TRBO and adverse events, such as cholecystitis and pancreatitis, in treatment of patients with unresectable malignant biliary obstruction using 8- and 10-mm diameter FCSEMS. METHODS: Eighteen tertiary-care centers participated in the study. Patients were allocated to the 8- and 10-mm diameter groups. TRBO, non-inferiority of the 8-mm FCSEMS, overall survival time, frequency and type of adverse events, and non-recurrent biliary obstruction (RBO) rate at the time of death were compared between the two groups. RESULTS: Median TRBO did not differ significantly between the 8-mm (n = 102) and 10-mm (n = 100) groups (275 vs 293 days, P = 0.971). The hazard ratio of the 8- to 10-mm groups was 0.90 (80% confidence interval, 0.77-1.04; upper limit lower than the acceptable hazard ratio [1.33] of the null hypothesis). Based on these findings, the 8-mm diameter stent was determined to be non-inferior to the 10-mm diameter stent. Survival time, incidence of adverse events and non-RBO rate at the time of death did not differ significantly between the two groups. CONCLUSIONS: Time to RBO with an 8-mm diameter FCSEMS was non-inferior to that with a 10-mm diameter FCSEMS. This finding is important for development of future SEMS.

    DOI: 10.1111/den.13366

    Web of Science

    Scopus

    PubMed

  169. USEFULNESS OF THE FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE IN THE DIAGNOSIS OF INVASION DEPTH OF COLORECTAL NEOPLASIA

    Kuno Takeshi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Suzuki Hiroto, Esaki Masaya, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 89 ( 6 ) page: AB324 - AB324   2019.6

     More details

  170. USEFULLNESS OF EUS-GUIDED SHEAR-WAVE MEASUREMENT (EUS-SWM) FOR THE ASSESSMENT OF ACTIVITIES OF AUTOIMMUNE PANCREATITIS; A PROSPECTIVE EXPLORATORY STUDY

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Tanaka Hiroyuki, Sakai Daisuke, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji

    GASTROINTESTINAL ENDOSCOPY   Vol. 89 ( 6 ) page: AB608 - AB608   2019.6

     More details

  171. CLINICAL SIGNIFICANCE OF THE PATENCY OF GASTROINTESTINAL TRACT IN CROHN'S DISEASE EVALUATED BY PATENCY CAPSULE

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Kuno Takeshi, Yamada Keisaku, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 89 ( 6 ) page: AB333 - AB333   2019.6

     More details

  172. ダブルバルーン小腸内視鏡を用いた硬化療法にて治療効果を得た小腸多発血管腫の1例

    山田 啓策, 山村 健史, 中村 正直, 澤田 つな騎, 水谷 泰之, 前田 啓子, 古川 和宏, 宮原 良二, 横井 太紀雄, 廣岡 芳樹

    Gastroenterological Endoscopy   Vol. 61 ( 6 ) page: 1231 - 1236   2019.6

     More details

    Language:Japanese   Publisher:(一社)日本消化器内視鏡学会  

    70歳代男性。1ヵ月間持続する黒色便にて当科紹介となった。上下部消化管内視鏡検査では、明らかな出血源を認めなかった。小腸出血を疑いカプセル内視鏡検査を施行したところ、全小腸にわたり多発する隆起性病変を認めた。ダブルバルーン小腸内視鏡検査を行いジャンボバイオプシー目的の内視鏡的粘膜切除術(Endoscopic mucosal resection:EMR)にて海綿状血管腫と診断した。後日多発する血管腫に対してpolidocanol(Aethoxysklerol)による硬化療法を行った。4日後の内視鏡観察では、血管腫は縮小を認め、以後黒色便も消失した。小腸に多発する血管腫に対して内視鏡的硬化療法が有用であった1例を経験したので報告する。(著者抄録)

  173. The utility of ultrathin endoscopy with flexible spectral imaging color enhancement for early gastric cancer. Reviewed

    Yokoyama T, Miyahara R, Funasaka K, Furukawa K, Yamamura T, Ohno E, Nakamura M, Kawashima H, Watanabe O, Hirooka Y, Hirakawa A, Goto H

    Nagoya journal of medical science   Vol. 81 ( 2 ) page: 241 - 248   2019.5

     More details

  174. Colorectal endoscopic submucosal dissection in special locations

    Kaosombatwattana Uayporn, Yamamura Takeshi, Nakamura Masanao, Hirooka Yoshiki, Goto Hidemi

    WORLD JOURNAL OF GASTROINTESTINAL ENDOSCOPY   Vol. 11 ( 4 ) page: 262 - 270   2019.4

  175. Preoperative endoscopic predictors of severe submucosal fibrosis in colorectal tumors undergoing endoscopic submucosal dissection

    Kaosombatwattana Uayporn, Yamamura Takeshi, Limsrivilai Julajak, Nakamura Masanao, Leelakusolvong Somchai, Hirooka Yoshiki, Goto Hidemi

    ENDOSCOPY INTERNATIONAL OPEN   Vol. 7 ( 4 ) page: E421 - E430   2019.4

  176. Development of a Comorbidity Index to Identify Patients With Small Bowel Bleeding at Risk for Rebleeding and Small Bowel Vascular Diseases. Reviewed International journal

    Ohmiya N, Nakamura M, Osaki H, Yamada H, Tahara T, Nagasaka M, Nakagawa Y, Shibata T, Tsukamoto T, Kuroda M

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   Vol. 17 ( 5 ) page: 896 - +   2019.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND & AIMS: We aimed to establish a comorbidity index for small bowel vascular diseases (SBVD) associated with small bowel bleeding (SBB) and recurrent bleeding. METHODS: We performed a retrospective analysis of 404 patients diagnosed with SBB via double-balloon enteroscopy, at 2 hospitals in Japan from June 2003 through July 2016. We collected data on comorbidities, computed Charlson Comorbidity Index and anticoagulation and risk factors in atrial fibrillation (ATRIA) scores, and analyzed associations with SBVD, rebleeding, and overall survival associated with bleeding and/or comorbidities. We used these data to develop a comorbidity index to identify patients at risk for SBVD, rebleeding, and reduced survival time. We validated our findings in a separate, prospective cohort of 88 patients with SBB. RESULTS: We developed a weighted index (the Ohmiya index) that identified patients who developed SBVD with an area under the receiver operating characteristic (AUROC) curve of 0.7758; this value was higher than that of the Charlson index score (0.6828; P < .0001) or ATRIA score (0.6728; P < .0001) alone. Among the 51 patients taking oral anticoagulants, there was no significant difference in AUROCs for the Ohmiya score (0.5254) vs the outcomes registry for better informed treatment score (0.5857; P = .4300). In the retrospective cohort, the Ohmiya index identified patients with SBVD with 68% sensitivity (93/137), 84% specificity (223/267), and 78% accuracy (316/404); in the validation cohort, these values were 63% (22/35), 85% (45/53), and 76% (67/88), respectively. Onset age <50 years and index score <2 identified patients with Meckel's diverticulum and Crohn's disease with 53% accuracy. Onset age ≥50 years and index score <2 identified patients with inflammatory diseases, drug-induced injuries, or tumors with 72% accuracy. An index score ≥2 identified patients with SBVD with 68% accuracy, regardless of age. Among patients with Ohmiya index scores ≥2, 33% had rebleeding; among patients with scores <2, 15% had rebleeding (hazard ratio for score ≥2, 1.729; 95% CI, 1.038-2.882; P = .0355). CONCLUSION: We developed an index, based on comorbidities and age of onset of SBB, that identified patients at risk for rebleeding and vascular disease (for example, enteroscopic hemostasis for SBVD, medication for inflammatory diseases, surgery with enteroscopic tattooing for tumors and diverticula). UMIN: 000025693.

    DOI: 10.1016/j.cgh.2018.08.034

    Web of Science

    Scopus

    PubMed

  177. Utility of linked color imaging for endoscopic diagnosis of early gastric cancer. Reviewed

    Fujiyoshi T, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Nakaguro M, Nakatochi M, Hirooka Y

    World journal of gastroenterology   Vol. 25 ( 10 ) page: 1248 - 1258   2019.3

     More details

  178. Capsule endoscopy findings for the diagnosis of Crohn's disease: a nationwide case-control study. Reviewed

    Esaki M, Matsumoto T, Ohmiya N, Washio E, Morishita T, Sakamoto K, Abe H, Yamamoto S, Kinjo T, Togashi K, Watanabe K, Hirai F, Nakamura M, Nouda S, Ashizuka S, Omori T, Kochi S, Yanai S, Fuyuno Y, Hirano A, Umeno J, Kitazono T, Kinjo F, Watanabe M, Matsui T, Suzuki Y

    Journal of gastroenterology   Vol. 54 ( 3 ) page: 249 - 260   2019.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Capsule endoscopy can be used to identify the early stage of small bowel Crohn's disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. METHODS: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD. Inter- and intra-observer agreement in the determination of lesions was assessed in 25 pairs of SBCE from the two groups. RESULTS: Under SBCE, cobblestone appearance (33% vs. 2%, p < 0.0001), longitudinal ulcers (78% vs. 20%, p < 0.0001), and irregular ulcers (84% vs. 60%, p < 0.01) were more frequently found in patients with CD. Linear erosion (90% vs. 38%, p < 0.0001) and irregular erosion (89% vs. 64%, p < 0.005) were also more frequent in patients with CD. Furthermore, circumferential (75% vs. 9%, p < 0.0001) and longitudinal (56% vs. 7%, p < 0.0001) alignment of diminutive lesions, mainly observed in the 1st tertile of the small bowel, was more frequent in patients with CD. Good intra-observer agreement was found for ulcers, cobblestone appearance, and lesion alignment. However, inter-observer agreement of SBCE findings differed among observers. CONCLUSIONS: Circumferential or longitudinal alignment of diminutive lesions, especially in the upper small bowel, may be a diagnostic clue for CD under SBCE, while inter-observer variations should be cautiously considered when using SBCE.

    DOI: 10.1007/s00535-018-1507-6

    Scopus

    PubMed

  179. Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy. Reviewed

    Ohmiya N, Hotta N, Mitsufuji S, Nakamura M, Omori T, Maeda K, Okuda K, Yatsuya H, Tajiri H

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 31 ( 2 ) page: 164 - 172   2019.3

     More details

  180. Transabdominal ultrasound elastography of the esophagogastric junction predicts reflux esophagitis. Reviewed

    Suhara H, Hirooka Y, Kawashima H, Ohno E, Ishikawa T, Nakamura M, Miyahara R, Ishigami M, Hashimoto S, Goto H

    Journal of medical ultrasonics (2001)   Vol. 46 ( 1 ) page: 99 - 104   2019.1

     More details

  181. Plummer-Vinson Syndrome with Esophageal Web Formation in which Detailed Endoscopic Images Were Obtained

    Hirose Takashi, Funasaka Kohei, Furukawa Kazuhiro, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki

    Internal Medicine   Vol. 58 ( 6 ) page: 785 - 789   2019

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Internal Medicine  

    <p>Plummer-Vinson syndrome is a rare entity, characterized by dysphagia, esophageal web formation, and iron deficiency anemia. The patient was a 63-year-old woman with a clinical history of iron deficiency anemia and glossitis in her 20s to 40s and who had experienced swallowing difficulties for the past 20 years. A membranous stricture was found in the cervical esophagus during a fluoroscopic examination. An endoscopic examination conducted under general anesthesia revealed an oblique linear scar on the proximal surface of the stricture. Sequential balloon dilation was performed successfully. We suggest that the esophageal web formation might have been related to the healing of an esophageal ulcer. </p>

    DOI: 10.2169/internalmedicine.1628-18

    Web of Science

    Scopus

    PubMed

    CiNii Research

  182. Lewis Score on Capsule Endoscopy as a Predictor of the Risk for Crohn's Disease-Related Emergency Hospitalization and Clinical Relapse in Patients with Small Bowel Crohn's Disease. International journal

    Takahiro Nishikawa, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Ryoji Miyahara, Hiroki Kawashima, Yoshiki Hirooka

    Gastroenterology research and practice   Vol. 2019   page: 4274257 - 4274257   2019

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Background: Small bowel capsule endoscopy (CE) is a useful tool for evaluating the mucosal changes in patients with Crohn's disease (CD). The Lewis score (LS) on CE could be used to objectively assess the inflammatory activity of the small bowel mucosa. However, only few reports on the correlation between the LS and CD prognosis exist. This study is aimed at evaluating the clinical significance of the LS by determining the cutoff value of the LS that could predict CD-related emergency hospitalization. Methods: This retrospective single-center study included 125 patients who underwent CE for small bowel CD. Eighty-six patients whose treatment was not changed after CE were analyzed. Inflammatory activity was assessed with the LS. We examined the clinical course of the patients who could be observed for 1 year after CE and investigated the LS cutoff value that could predict CD-related emergency hospitalization within 1 year. We also examined the hospitalization-free and clinical relapse-free rates using the LS cutoff value and evaluated the factors related to emergency hospitalization. Results: The LS cutoff value that could predict CD-related emergency hospitalization within 1 year was 264 (area under the curve, 0.92 (P < 0.001); sensitivity, 0.80; and specificity, 0.94). The cumulative hospitalization-free rate and cumulative clinical relapse-free rate were significantly higher in patients with a LS < 264 (P < 0.001). Multivariate analysis showed that a LS < 264 was a statistically significant factor (P = 0.001; 95% CI, 0.010-0.308). Conclusion: A LS of 264 is a useful cutoff value that could predict CD-related emergency hospitalization. This LS cutoff value may help determine treatment strategies for CD.

    DOI: 10.1155/2019/4274257

    Web of Science

    Scopus

    PubMed

    CiNii Research

  183. Clinical Impact of EUS-Guided Fine Needle Biopsy Using a Novel Franseen Needle for Histological Assessment of Pancreatic Diseases

    Takuya Ishikawa, Hiroki Kawashima, Eizaburo Ohno, Hiroyuki Tanaka, Daisuke Sakai, Tadashi Iida, Ryo Nishio, Takeshi Yamamura, Kazuhiro Furukawa, Masanao Nakamura, Ryoji Miyahara, Senju Hashimoto, Masatoshi Ishigami, Yoshiki Hirooka

    Canadian Journal of Gastroenterology and Hepatology   Vol. 2019   page: 8581743 - 8   2019

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Hindawi Limited  

    <italic>Background and Aims</italic>. Several studies have shown the benefits of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) using a Franseen needle for histological assessment. However, studies focusing on pancreatic diseases are limited and the safety of this method has not been well assessed. We aimed to assess the current status and issues of EUS-FNB in the diagnosis of pancreatic diseases.<italic> Materials and Methods</italic>. We retrospectively reviewed 87 consecutive EUS-FNB specimens using either a 22-gauge Franseen needle (Group A, N = 51) or a conventional 22-gauge fine-needle aspiration needle (Group B, N = 36) for pancreatic diseases, and the diagnostic accuracy and safety were compared. Final diagnoses were obtained based on surgical pathology or a minimum six-month clinical follow-up.<italic> Results</italic>. Although the diagnostic accuracy for malignancy was 96.1% in Group A versus 88.9% in Group B, with no statistically significant difference (<italic>P</italic> = 0.19), the median sample area was significantly larger in Group A (4.07 versus 1.31mm<sup>2</sup>,<italic> P</italic> &lt; 0.0001). There were no differences between the two needles in the locations from which the specimens were obtained. Adverse events occurred in one case (2%) in Group A (mild pancreatitis) and none in Group B with no statistical significance (<italic>P</italic> = 0.586). Although there was no case of bleeding defined as adverse events, 2 cases in Group A showed active bleeding during the procedure with increase in the echo-free space, which required CT scanning to rule out extravasation. Eventually, the bleeding stopped spontaneously.<italic> Conclusions</italic>. Given its guaranteed ability to obtain core specimens and comparable safety, and although the risk of bleeding should be kept in mind, EUS-FNB using a Franseen needle is likely to become a standard procedure for obtaining pancreatic tissue in the near future.

    DOI: 10.1155/2019/8581743

    Web of Science

    Scopus

    PubMed

    Other Link: http://downloads.hindawi.com/journals/cjgh/2019/8581743.xml

  184. Clinicopathological analysis of primary intestinal diffuse large B-cell lymphoma: Prognostic evaluation of CD5, PD-L1, and Epstein-Barr virus on tumor cells

    Ishikawa Eri, Kato Seiichi, Shimada Kazuyuki, Tanaka Tsutomu, Suzuki Yuka, Satou Akira, Kohno Kei, Sakakibara Ayako, Yamamura Takeshi, Nakamura Masanao, Miyahara Ryoji, Goto Hidemi, Nakamura Shigeo, Hirooka Yoshiki

    CANCER MEDICINE   Vol. 7 ( 12 ) page: 6051 - 6063   2018.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cam4.1875

    Web of Science

    PubMed

    CiNii Research

  185. Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease. Reviewed

    Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Kawashima H, Miyahara R, Koulaouzidis A, Hirooka Y, Nagoya University Crohn’s Disease Study Group

    Journal of clinical medicine   Vol. 7 ( 10 )   2018.10

  186. Prospective study predicting histology in colorectal lesions using wNICE, wJNET, and MS classifications

    Pu L. Zorron Cheng Tao, Yamamura T., Nakamura M., Koay D. S. C., Ovenden A., Edwards S., Hoong C. K., Burt A. D., Hirooka Y., Singh R.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 33   page: 14 - 14   2018.9

     More details

  187. Prevalence and distribution of serrated polyps in the colon

    Pu L. Zorron Cheng Tao, Singh G., Krishnamurthi S., Ovenden A., Nakamura M., Yamamura T., Rana K., Lu K., Edwards S., Ruszkiewicz A., Hoong C. K., Hirooka Y., Burt A. D., Singh R.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 33   page: 185 - 186   2018.9

     More details

  188. Effect of training and time of the day on polyp detection rates

    Pu L. Zorron Cheng Tao, Lu K., Ovenden A., Rana K., Singh G., Krishnamurthi S., Edwards S., Wilson B., Nakamura M., Yamamura T., Ruszkiewicz A., Hoong C. K., Hirooka Y., Burt A. D., Singh R.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 33   page: 184 - 185   2018.9

     More details

  189. Objective evaluation of blood flow in the small-intestinal villous: quantification of findings from dynamic endoscopy with concomitant narrow-band imaging. Reviewed International journal

    Takeyama T, Hirooka Y, Kawashima H, Ohno E, Ishikawa T, Yamamura T, Furukawa K, Funasaka K, Nakamura M, Miyahara R, Ishigami M, Goto H

    Endoscopy international open   Vol. 6 ( 8 ) page: E941 - E949   2018.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Background and aims:  We have previously shown that the increase in blood flow volume in jejunum villi after spraying of 10 % dextrose solution correlates with pancreatic exocrine function (PEF). The aim of this study was to establish an objective method to evaluate the amount of jejunum villous blood flow using a novel image analysis system. Patients and methods:  The subjects were 26 patients who underwent upper gastrointestinal endoscopy with a newly developed small intestine endoscope (SIF-Y0007, Olympus, Tokyo, Japan). By defining the ratio of capillary occupancy in each villus at levels from 1 to 5, villous blood flow was evaluated subjectively on the villous blood flow scale (VBFS). Objective evaluation was performed based on luminance analysis. The morphological opening process was used to make images with leveled brightness. A histogram was prepared from the luminance information and the standard deviation was determined and defined as SDOV (Standard Deviation calculated from a histogram made by luminance analysis Of Villi). PEF was evaluated by measuring the BT-PABA (N-benzoyl-L-tyrosyl-p-aminobenzoic acid) excretion rate. Results:  There was a significant positive correlation between VBFS and SDOV ( P  < 0.0001, ρ = 0.5882). SDOV was also positively correlated with PEF ( P  = 0.0004, ρ = 0.6421). Conclusions:  SDOV is a new objective index for evaluation of blood flow volume in jejunum villi. SDOV may be useful in clinical practice to estimate PEF and for clarification of the mechanisms underlying the functional correlation between the pancreas and small intestine.

    DOI: 10.1055/a-0619-4965

    Web of Science

    PubMed

  190. groove膵癌の1症例

    橋詰 清孝, 廣岡 芳樹, 川嶋 啓揮, 大野 栄三郎, 石川 卓哉, 桑原 崇通, 河合 学, 須原 寛樹, 竹山 友章, 小屋 敏也, 松下 正伸, 山村 健史, 古川 和宏, 舩坂 好平, 中村 正直, 宮原 良二, 渡辺 修, 後藤 秀実

    肝胆膵治療研究会誌   Vol. 15 ( 1 ) page: 39 - 46   2018.8

     More details

    Language:Japanese   Publisher:肝胆膵治療研究会  

    症例は60歳代男性。膵頭部腫大と肝胆道系酵素高値にて当院紹介受診となった。造影CT検査ではgroove領域に正常膵実質と比較し、早期動脈相・後期動脈相では低吸収、門脈相でほぼ等吸収、平衡相でやや高吸収な腫瘤様所見を認めた。肝内・肝外胆管は拡張しており、膵内胆管に狭窄を認めたが、主膵管拡張は認めなかった。ERCP施行時、副乳頭周囲の十二指腸粘膜に発赤・襞のひきつれ所見を認めた。膵管像は膵頭部の主膵管に不整所見を認め、副膵管は造影されなかった。胆管像では膵内胆管の狭窄は平滑であった。EUSでは膵頭部に径約30mmの輪郭不明瞭な低エコー腫瘤を認めた。Sonazoidを用いた造影では全体が均一に染影されたが、内部に造影効果が著明に減弱する部位を認めた。診断目的にEUS-FNAを施行したが悪性所見は認めず、ERCP施行時の副乳頭周囲と胆管狭窄部からの生検でも悪性所見は認めなかった。画像診断(特に膵管造影所見)より悪性疾患の可能性が否定できず、十分な説明のもと膵頭十二指腸切除術を施行した。病理結果はgroove膵癌であった。(著者抄録)

  191. groove膵癌の一例

    橋詰 清孝, 廣岡 芳樹, 川嶋 啓揮, 大野 栄三郎, 桑原 崇通, 森島 大雅, 河合 学, 須原 寛樹, 竹山 友章, 小屋 敏也, 山村 健史, 舩坂 好平, 中村 正直, 宮原 良二, 渡辺 修, 後藤 秀実

    肝胆膵治療研究会誌   Vol. 15 ( 1 ) page: 101 - 101   2018.8

     More details

    Language:Japanese   Publisher:肝胆膵治療研究会  

  192. Increase in breath hydrogen concentration was correlated with the main pancreatic duct stenosis

    Sakai Daisuke, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Tsuruta Akihiro, Shin Woosuck, Goto Hidemi

    JOURNAL OF BREATH RESEARCH   Vol. 12 ( 3 ) page: 036004   2018.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1088/1752-7163/aaaf77

    Web of Science

    PubMed

  193. A prognostic model, including the EBV status of tumor cells, for primary gastric diffuse large B-cell lymphoma in the rituximab era. Reviewed International journal

    Eri Ishikawa, Tsutomu Tanaka, Kazuyuki Shimada, Kei Kohno, Akira Satou, Ahmed E Eladl, Ayako Sakakibara, Kazuhiro Furukawa, Kohei Funasaka, Ryoji Miyahara, Masanao Nakamura, Hidemi Goto, Shigeo Nakamura, Seiichi Kato, Yoshiki Hirooka

    Cancer medicine   Vol. 7 ( 7 ) page: 3510 - 3520   2018.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    EBV-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS), often affects the gastrointestinal tract. However, the prognostic significance of EBV associated with primary gastric DLBCL (gDLBCL) has not been established. This retrospective study included 240 patients with primary gDLBCL, diagnosed between 1995 and 2015. Tumor specimens were analyzed with EBER in situ hybridization. In 25 (10%) cases, tumor cells harbored EBV. The EBV+ group more frequently exhibited programmed death-ligand 1 (PD-L1) expression in microenvironment immune cells, but not tumor cells, compared to the EBV- group (86% vs 43%, P = .006). Among 156 patients that received rituximab-containing chemotherapy, the EBV+ group had a significantly worse overall survival (OS) than the EBV- group (P = .0029). Multivariate analyses identified 3 independent adverse prognostic factors of OS: multiple gastric lesions (P = .002), EBER positivity (P = .003), and B symptoms (P = .018). These factors were combined to develop a gDLBCL prognostic (gDLP) model that significantly stratified the patients into 3 distinct risk groups (Scores: good = 0, intermediate = 1, and poor = 2/3, P < .0001) with 5-year OS rates of 100%, 81%, and 39%, respectively. Patients with EBV+ gDLBCL commonly exhibited microenvironmental PD-L1 expression and showed a significantly worse prognosis than subjects with EBV- gDLBCL. Our gDLP model, which included EBV+ tumor cells, provided good predictions of clinical outcome and may be useful for selecting patients in trials in the immune-oncology era.

    DOI: 10.1002/cam4.1595

    Web of Science

    PubMed

    CiNii Research

  194. EVALUATION OF LOCAL RECURRENCE AFTER COLD POLYPECTOMY COMPARED WITH CONVENTIONAL HOT POLYPECTOMY IN A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL

    Yamamura Takeshi, Saito Masashi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Suzuki Hiroto, Otsuka Hiroyuki, Uchida Genta, Nishikawa Takahiro, Ishida Tetsuya, Kuno Takeshi, Yamada Keisaku, Hattori Shun, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB478-AB478   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  195. ENDOSCOPIC TREATMENT FOR SUPERFICIAL NON-AMPULLARY DUODENAL TUMORS

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB315-AB316   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  196. USEFULNESS OF HISTOLOGICAL ASSESSMENT WITH EUS-GUIDED FINE NEEDLE BIOPSY USING A NEW CORE NEEDLE IN PANCREATIC DISEASES

    Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB432 - AB433   2018.6

     More details

  197. USEFULLNESS OF CONTRAST-ENHANCED HARMONIC EUS(CH-EUS) FOR THE PREOPERATIVE ASSESSMENT OF MPD INVOLVEMENT IN IPMN; A RETROSPECTIVE COMPARISON STUDY OF CH-EUS AND IDUS

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Furukawa Kazuhiro, Yamamura Takeshi, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB426 - AB427   2018.6

     More details

  198. THE DIAGNOSTIC ABILITY AND PITFALL OF JNET(JAPAN NBI EXPERT TEAM)CLASSIFICATION IN TRAINEES

    Suzuki Hiroto, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Niwa Yoshiki, Uchida Genta, Otsuka Hiroyuki, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keisaku, Hattori Shun, Kajikawa Go, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB489 - AB490   2018.6

     More details

  199. PROSPECTIVE STUDY OF SMALL BOWEL CAPSULE ENDOSCOPY FOR EVALUATING THE THERAPEUTIC EFFECTS IN PATIENTS WITH CROHN'S DISEASE

    Nakamura Masanao, Hirooka Yoshiki, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Koulaouzidis Anastasios, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB393 - AB393   2018.6

     More details

  200. OUTCOMES AND PREDICTORS OF SEVERE SUBMUCOSAL FIBROSIS IN COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION

    Kaosombatwattana Uayporn, Yamamura Takeshi, Limsrivilai Julajak, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Leelakusolvong Somchai, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB377 - AB377   2018.6

     More details

  201. DIAGNOSTIC IMAGING SYSTEM WITH VIRTUAL ENTEROSCOPY AND COMPUTER-AIDED DETECTION FOR EVALUATION OF SMALL BOWEL LESIONS OF CROHN'S DISEASE

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Oda Masahiro, Mori Kensaku, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB304 - AB304   2018.6

     More details

  202. ENDOSCOPIC TREATMENT FOR SUPERFICIAL NON-AMPULLARY DUODENAL TUMORS

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB315-AB316   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  203. USEFULNESS OF HISTOLOGICAL ASSESSMENT WITH EUS-GUIDED FINE NEEDLE BIOPSY USING A NEW CORE NEEDLE IN PANCREATIC DISEASES

    Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB432-AB433   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  204. PROSPECTIVE STUDY OF SMALL BOWEL CAPSULE ENDOSCOPY FOR EVALUATING THE THERAPEUTIC EFFECTS IN PATIENTS WITH CROHN'S DISEASE

    Nakamura Masanao, Hirooka Yoshiki, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Koulaouzidis Anastasios, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB393-AB393   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  205. OUTCOMES AND PREDICTORS OF SEVERE SUBMUCOSAL FIBROSIS IN COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION

    Kaosombatwattana Uayporn, Yamamura Takeshi, Limsrivilai Julajak, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Leelakusolvong Somchai, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB377-AB377   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  206. EVALUATION OF LOCAL RECURRENCE AFTER COLD POLYPECTOMY COMPARED WITH CONVENTIONAL HOT POLYPECTOMY IN A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL

    Yamamura Takeshi, Saito Masashi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Suzuki Hiroto, Otsuka Hiroyuki, Uchida Genta, Nishikawa Takahiro, Ishida Tetsuya, Kuno Takeshi, Yamada Keisaku, Hattori Shun, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB478-AB478   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  207. Multiphase evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic solid lesions

    Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Hashizume Kiyotaka, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Goto Hidemi

    PANCREATOLOGY   Vol. 18 ( 3 ) page: 291 - 297   2018.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pan.2018.02.002

    Web of Science

    PubMed

  208. Usefulness of shear wave elastography as a quantitative diagnosis of chronic pancreatitis. International journal

    Takamichi Kuwahara, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Senju Hashimoto, Hidemi Goto

    Journal of gastroenterology and hepatology   Vol. 33 ( 3 ) page: 756 - 761   2018.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND AND AIM: Chronic pancreatitis (CP) is sometimes diagnosed at the progressed stage. For the early diagnosis of CP, endoscopic ultrasonography (EUS) may be a useful method, but its diagnostic criteria is based on subjective judgment. Shear wave elastography (SW-EG) using transabdominal ultrasonography, which quantifies tissue elasticity as an absolute value, may be an objective and noninvasive method for the diagnosis of CP. METHODS: Eighty-five patients with known or suspected CP who underwent both EUS and SW-EG from October 2012 to July 2016 were included in this study. Patients were categorized into four stages using Rosemont classification and into three stages using Japan Pancreas Society clinical diagnostic criteria 2009 that was EUS-based criteria for the diagnosis of CP. SW-EG was measured five times in the pancreatic parenchyma, and the median value was defined as the pancreatic elastic modulus (PEM). RESULTS: Pancreatic elastic modulus was significantly positively correlated with Rosemont classification stage (rs  = 0.54), Japan Pancreas Society stage (rs  = 0.41), and the number of EUS features (rs  = 0.47). Area under the receiver operating characteristic curve for the accuracy of SW-EG (consistent with CP and suggestive of CP vs normal and indeterminate for CP) was 0.77 (sensitivity 77.1%, specificity 64.9%). In a multivariate linear regression analysis including various EUS features related to PEM, hyperechoic foci with shadowing and lobularity with honeycombing were independent features related to PEM. CONCLUSIONS: Chronic pancreatitis may be diagnosed noninvasively and objectively using SW-EG without performing EUS.

    DOI: 10.1111/jgh.13926

    Web of Science

    PubMed

  209. Clinical significance of gastrointestinal patency evaluation by using patency capsule in Crohn's disease

    Yoshimura Toru, Hirooka Yoshiki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 1 ) page: 121 - 128   2018.2

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.80.1.121

    Web of Science

    PubMed

  210. Multiple keratotic papules and plaques on the trunk in Cowden's disease with MALT lymphoma. Reviewed International journal

    Sayaka Mizuno, Takuya Takeichi, Junichi Sato, Masanao Nakamura, Hidemi Goto, Kazumitsu Sugiura, Masashi Akiyama

    The Journal of dermatology   Vol. 45 ( 2 ) page: 238 - 240   2018.2

  211. Associations between drugs and small-bowel mucosal bleeding: Multicenter capsule-endoscopy study. Reviewed

    Niikura R, Yamada A, Maki K, Nakamura M, Watabe H, Fujishiro M, Oka S, Esaki M, Fujimori S, Nakajima A, Ohmiya N, Matsumoto T, Tanaka S, Koike K, Sakamoto C

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 30 ( 1 ) page: 79 - 89   2018.1

     More details

  212. Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy. Reviewed

    Hayashi D, Hirooka Y, Kawashima H, Ohno E, Ishikawa T, Kuwahara T, Kawai M, Yamamura T, Furukawa K, Funasaka K, Nakamura M, Miyahara R, Watanabe O, Ishigami M, Hashimoto S, Goto H

    Pancreas   Vol. 47 ( 5 ) page: 601 - 608   2018

  213. Endoscopic ultrasound in diagnosis of solid pancreatic lesions: Elastography or contrast-enhanced harmonic alone versus the combination

    Chantarojanasiri Tanyaporn, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Kuwahara Takamichi, Yamamura Takeshi, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Watanabe Osamu, Hashimoto Senju, Hirakawa Akihiro, Ratanachu-ek Thawee, Goto Hidemi

    ENDOSCOPY INTERNATIONAL OPEN   Vol. 5 ( 11 ) page: E1136 - E1143   2017.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0043-118829

    Web of Science

    PubMed

  214. Development and validation of a new scoring system to determine the necessity of small-bowel endoscopy in obscure gastrointestinal bleeding Reviewed

    Genta Uchida, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto, Yoshiki Hirooka

    DIGESTIVE AND LIVER DISEASE   Vol. 49 ( 11 ) page: 1218 - 1224   2017.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Background: Small bowel capsule endoscopy (SBCE) is the recommended first-line procedure for obscure gastrointestinal bleeding (OGIB). However, a method for predicting the necessity of subsequent double-balloon endoscopy (DBE) has not been established.
    Aims: We aimed to develop a new scoring system that predicts the necessity of DBE in OGIB.
    Methods: A retrospective study was performed in 330 patients who underwent SBCE for OGIB at Nagoya University Hospital. The enrolled patients were randomly assigned to either a development or a validation dataset. The former was used to construct a prediction scoring system to assess the necessity of DBE using independent predictors selected by logistic regression. The diagnostic yield of the prediction model was assessed using the validation dataset.
    Results: Multivariate logistic regression analysis of the development dataset identified OGIB type, blood transfusion, and SBCE findings as independent predictors of the necessity of DBE. A prediction score gave an area under the receiver operating characteristics curve of 0.77. The sensitivity, specificity, positive predictive value, and negative predictive value at a cutoff &gt;= 2.5 points were 72.5%, 74.6%, 72.6%, and 74.5%, respectively.
    Conclusion: Our scoring system may aid clinicians in deciding when to recommend DBE for patients with OGIB. (C) 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.dld.2017.08.036

    Web of Science

    PubMed

  215. In vivo histological diagnosis for gastric cancer using endocytoscopy Reviewed

    Issei Tsurudome, Ryoji Miyahara, Kohei Funasaka, Kazuhiro Furukawa, Masanobu Matsushita, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Osamu Watanabe, Masato Nakaguro, Akira Satou, Yoshiki Hirooka, Hidemi Goto

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 23 ( 37 ) page: 6894 - 6901   2017.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:BAISHIDENG PUBLISHING GROUP INC  

    AIM
    To examine usefulness of virtual biopsy using endocytoscopy by comparing the in vivo endocytoscopic and histopathological images of gastric cancers.
    METHODS
    Endocytoscopy was performed in 30 patients with early gastric cancer. Of these, 26 patients showed well differentiated adenocarcinomas, while 4 patients showed poorly differentiated adenocarcinomas (including one signet ring cell carcinoma). Cancerous and non-cancerous areas were observed after double staining with 0.05% crystal violet and 0.1% methylene blue. The endocytoscopic images obtained were evaluated by an expert endoscopist and an expert pathologist without knowledge of patient clinical data, and endocytoscopic and histopathological diagnoses were compared.
    RESULTS
    The endocytoscopic images of the cancerous area were assessed as evaluable in 25 (83.3%) and 27 (90%) patients by endoscopist A and pathologist B, respectively, and those of the non-cancerous area as evaluable in 28 (93.3%) and 23 (76.7%) patients by the endoscopist and pathologist, respectively. The sensitivity, specificity, and diagnostic accuracy of gastric cancer diagnosis using evaluable endocytoscopic images were 88.0% and 92.9%, and 90.6% by endoscopist A, and 88.9% and 91.3%, and 90.0% by pathologist B, respectively. Evaluation of the diagnostic concordance rate between the endoscopist and the pathologist by inter-observer agreement calculation revealed no significant difference between the two observers. The inter-observer agreement (kappa-value) for endocytoscopic diagnosis was 0.745.
    CONCLUSION
    Endocytoscopy is useful for the differentiation of cancerous from non-cancerous gastric mucosa, making it a promising tool for virtual biopsy.

    DOI: 10.3748/wjg.v23.i37.6894

    Web of Science

    PubMed

  216. ETV1 expression would be a predictive marker of malignancy in GIST

    Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 32   page: 79-80   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  217. Making decision to treat with infliximab by the result of periodic surveillance with double-balloon endoscopy after ilectomy can obtain mucosal healing and avoid re-operation on patients with Crohn's disease for a long-term follow-up study

    Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Saito Masashi, Matsuura Rinzaburou, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keishi, Kuno Takeshi, Hattori Shun, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 32   page: 287 - 287   2017.9

     More details

  218. ETV1 expression would be a predictive marker of malignancy in GIST

    Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 32   page: 79-80   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  219. Making decision to treat with infliximab by the result of periodic surveillance with double-balloon endoscopy after ilectomy can obtain mucosal healing and avoid re-operation on patients with Crohn's disease for a long-term follow-up study

    Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Saito Masashi, Matsuura Rinzaburou, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keishi, Kuno Takeshi, Hattori Shun, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 32   page: 287-287   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  220. Clinical factors related to false-positive rates of patency capsule examination Reviewed

    Tsunaki Sawada, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Elzaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto, Yoshiki Hirooka

    THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   Vol. 10 ( 8 ) page: 589 - 598   2017.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:SAGE PUBLICATIONS LTD  

    Background: Retention is the most common complication of capsule endoscopy (CE), and is reported to occur in 0-13% of cases. To avoid retention, a PillCam patency capsule (PC) is used in patients with suspected intestinal stenosis. However, a relatively low positive predictive value of the PC examination has been reported previously. The aims of this study were to clarify the accuracy of PC examination and to evaluate clinical factors related to cases of false-positive detection.
    Methods: We performed a retrospective single-center study of 282 consecutive patients referred for PC examination. Patients in which the PC could not pass through the small bowel within 33 h were classified into the 'no patency' group. The 'no patency' group was investigated for evidence of significant stenosis upon further examinations, including CE, double-balloon endoscopy, and small bowel follow-through after PC examination. Clinical factors related to small bowel patency and false-positive cases were evaluated.
    Results: We included 161 male (57.1%) and 121 female (42.9%) patients with a mean age of 47.5 17.7 years. Of the 282 patients enrolled, 27 patients exhibited 'no patency' upon PC examination. Multivariate analysis showed that clinical factors related to 'no patency' included Crohn's disease, abdominal symptoms, stenosis upon imaging, and previous abdominal surgery. Upon further examination, nine cases in the 'no patency' group had significant stenosis. Sensitivity, specificity, and negative and positive predictive values of PC examination for detecting small bowel stenosis were 93.8%, 96.6%, 99.6%, and 62.5%, respectively, and the only clinical factor related to false-positive cases was constipation (p &lt; 0.05).
    Conclusion: We found a relatively low positive predictive value of PC examination and that constipation was related to false-positive results. To extend the implications of CE indications, clinical study focusing on these results is expected.

    DOI: 10.1177/1756283X17722744

    Web of Science

    PubMed

  221. Quantitative diagnosis of chronic pancreatitis using EUS elastography.

    Takamichi Kuwahara, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Manabu Kawai, Hiroki Suhara, Tomoaki Takeyama, Kiyotaka Hashizume, Toshinari Koya, Hiroyuki Tanaka, Daisuke Sakai, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Senju Hashimoto, Hidemi Goto

    Journal of gastroenterology   Vol. 52 ( 7 ) page: 868 - 874   2017.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: It is difficult to diagnose chronic pancreatitis (CP) objectively because of a lack of standard diagnostic criteria. Endoscopic ultrasonography (EUS) has been used to assess the severity of CP, but the diagnosis of CP using EUS depends on an endosnonographer. The aim of this study was to establish an objective diagnostic method for CP using EUS elastography (EUS-EG). METHODS: A retrospective study was designed and 96 patients underwent EUS-EG for follow-up of known CP, or who were clinically suspected as having CP. CP patients were categorized CP patients as 4 stages using the Rosemont classification (RC). EUS-EG was performed and the "Mean value", which was negatively correlated with pancreatic fibrosis, was calculated using histogram analysis. RESULTS: The "Mean value" of each RC stage (normal, indeterminate for CP, suggestive of CP, and consistent with CP) was 90.1 ± 19.3, 73.2 ± 10.6, 63.7 ± 14.2, and 56.1 ± 13.6, respectively, and showed significant differences for each stage (p < 0.001). There was a significant negative correlation between the "Mean value" and the number of EUS features (r s = -0.59, p < 0.001). Multiple linear regression analysis was used to assess the diagnostic finding of the "Mean value" and showed that hyperechoic foci with shadowing and lobularity with honeycombing maintained their independent diagnostic findings. CONCLUSIONS: EUS-EG was an objective diagnostic apparatus for CP and provided objective information to support EUS features.

    DOI: 10.1007/s00535-016-1296-8

    Web of Science

    PubMed

  222. Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction Reviewed

    Kazuhiro Ishiguro, Osamu Watanabe, Masanao Nakamura, Takeshi Yamamura, Masanobu Matsushita, Hidemi Goto, Yoshiki Hirooka

    CLINICAL IMMUNOLOGY   Vol. 180   page: 120 - 127   2017.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    4-Chloro-7-nitro-2,1,3-benzoxadiazole (NBD-CI) functions as a hapten and fluoresces upon binding to proteins. Therefore, fluorescence visualization of hapten-proteins is a feature of the colitis induced by NBD-Cl. Using this colitis model, we located activated fibroblasts in the vicinity of hapten-proteins upon colitis induction and observed interleukin (IL)-6 production in the activated fibroblasts. We screened herbal ingredients using primary fibroblasts stimulated with tumor necrosis factor alpha (TNF-alpha) and found the suppressive action of Atractylodin on IL-6 production. Under TNF-alpha stimulation, Atractylodin induced the tri-methylation of histone H3 at lysine residue 9, which impaired the binding between NF-kappa B and the IL-6 promoter on the genomic DNA. Atractylodin inhibited KDM4A but not KDM6A activity. Atractylodin administration attenuated colitis induction. The KDM4A inhibitor ML324 showed similar actions on IL-6 production and colitis induction. We propose the inhibition of KDM4A activity as a strategy to suppress IL-6 production and attenuate colitis induction. (C) 2017 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.clim.2017.05.014

    Web of Science

    PubMed

  223. Combinational use of lipid-based reagents for efficient transfection of primary fibroblasts and hepatoblasts Reviewed

    Kazuhiro Ishiguro, Osamu Watanabe, Masanao Nakamura, Takeshi Yamamura, Masanobu Matsushita, Hidemi Goto, Yoshiki Hirooka

    BIOTECHNIQUES   Vol. 63 ( 1 ) page: 37 - 39   2017.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:BIOTECHNIQUES OFFICE  

    Commercially available lipid-based transfection reagents are widely used to deliver DNA to cells. However, these lipid-based transfection reagents show poor gene transfer efficiency in primary cells. Here, we demonstrate a simple method to improve gene transfer efficiency in primary fibroblasts and hepatoblasts using a combination of lipid-based transfection reagents. Our data show that combined use of Lipofectamine LTX and FuGENE HD increases the efficiency of gene transfer compared with the use of either reagent alone, and this combination achieves the best result of any pairwise combination of Lipofectamine LTX, FuGENE HD, TransFectin, and Fibroblast Transfection Reagent.

    DOI: 10.2144/000114569

    Web of Science

    PubMed

    CiNii Research

  224. The Study of Diagnostic Ability for the Colorectal Neoplasms by Imaged Enhanced Endoscopy Using by JNET (Japan NBI Expert Team) Classification

    Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Saito Masashi, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB402-AB402   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  225. Establishment of a New Scoring System for Predicting the Necessity of Double-Balloon Endoscopy in Obscure Gastrointestinal Bleeding

    Uchida Genta, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB300-AB300   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  226. The Outcome of Treatment in Hypopharyngeal and Cervical Esophageal Carcinoma

    Fujiyoshi Toshihisa, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB597 - AB598   2017.5

     More details

  227. Predicting the Depth of Invasion of Esophageal Squamous Cell Carcinoma: Under Experience of Linked Colored Imaging With LED Light Source

    Kobayashi Kenichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB527 - AB527   2017.5

     More details

  228. Clinical Factors Related to False Positive Rates of Patency Capsule Examination

    Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB305 - AB305   2017.5

     More details

  229. Novel EMR Technique for Preoperative Diagnosis and Treatment of Submucosal Tumor in the Small Bowel at Double-Balloon Endoscopy

    Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB300 - AB300   2017.5

     More details

  230. Objective Assessment of Jejunal Villous Blood Flow for Evaluating Pancreas-Jejunum Functional Correlation Using a Novel Image Analyzing System

    Takeyama Tomoaki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Hashizume Kiyotaka, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB319 - AB320   2017.5

     More details

  231. One Year Follow-Up After Cold Polypectomy Compared With Hot Polypectomy for Small Colorectal Polyps - a Prospective Randomized Controlled Trial

    Saito Masashi, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB365 - AB366   2017.5

     More details

  232. A prospective randomised study comparing double-balloon colonoscopy and conventional colonoscopy in pre-defined technically difficult cases.

    Despott EJ, Murino A, Nakamura M, Bourikas L, Fraser C

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver   Vol. 49 ( 5 ) page: 507 - 513   2017.5

  233. Comparison of the diagnostic ability of blue laser imaging magnification versus pit pattern analysis for colorectal polyps

    Nakano Arihiro, Hirooka Yoshiki, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi

    ENDOSCOPY INTERNATIONAL OPEN   Vol. 5 ( 4 ) page: E224 - E231   2017.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0043-102400

    Web of Science

    PubMed

  234. 【消化管結核の診断と治療-最近の進歩】抗結核薬による診断的治療が奏効した小腸多発潰瘍の1例

    齋藤 雅之, 中村 正直, 渡辺 修, 山村 健史, 松下 正伸, 中野 有泰, 大島 啓嗣, 佐藤 淳一, 松浦 倫三郎, 舩坂 好平, 大野 栄三郎, 川嶋 啓揮, 宮原 良二, 廣岡 芳樹, 後藤 秀実

    胃と腸   Vol. 52 ( 2 ) page: 233 - 238   2017.2

     More details

    Language:Japanese   Publisher:(株)医学書院  

    患者は60歳代,女性.下痢,食欲不振にて受診.腹部CT検査で腸間膜リンパ節腫大,腸管壁肥厚を認め,大腸内視鏡検査で回腸末端のびらんを認めた.小腸カプセル内視鏡検査およびバルーン内視鏡検査で中部空腸〜回腸末端までほぼ全域で多発する網目状潰瘍を認めた.生検では陰窩膿瘍を認めていた.Crohn病としてステロイド薬が投与されたが,病状悪化,血中サイトメガロウイルス(CMV)アンチゲネミアが陽転化し,CMV腸炎の診断で,ガンシクロビルが投与されたが,潰瘍治癒は得られなかった.結核菌,乾酪性肉芽腫は未検出,抗結核特異INF-γ陰性であったが,腸結核の可能性を考慮し,抗結核薬による診断的治療を行った.4ヵ月後に行った小腸内視鏡にて小腸潰瘍の消失を確認した.(著者抄録)

  235. Specific characteristics of hemorrhagic Meckel's diverticulum at double-balloon endoscopy

    Mizutani Yasuyuki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Murino Alberto, Goto Hidemi, Hirooka Yoshiki

    ENDOSCOPY INTERNATIONAL OPEN   Vol. 5 ( 1 ) page: E35 - E40   2017.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0042-119810

    Web of Science

    PubMed

  236. Prospective study of factors important to achieve observation of the entire colon on colon capsule endoscopy Reviewed

    Junichi Sato, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Kohei Funasaka, Eizaburo Ohno, Ryoji Miyahara, Hiroki Kawashima, Hidemi Goto, Yoshiki Hirooka

    THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   Vol. 10 ( 1 ) page: 20 - 31   2017.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:SAGE PUBLICATIONS LTD  

    Background: Colon capsule endoscopy (CCE) is a procedure in which capsule swallowing facilitates observation of the lumen of the entire digestive tract. It does not require an air supply, and is a noninvasive procedure with a markedly low risk of adverse events in comparison with conventional colonoscopy (CS). It reduces patient stress, and may be acceptable to patients. A limitation of this procedure is that the entire colon observation rate (CCE excretion rate, completed CCE rate) is not 100%. In this study, we prospectively investigated clinical factors important to achieve observation of the entire colon on CCE.
    Methods:The participants were 70 patients for whom CCE was scheduled, and from whom written informed consent regarding participation in this study was obtained. We selected patient background/examination factors, and analyzed all factors involved in observation of the entire colon and factors for completion of the CCE within 4 h after the start of examination using multivariate analysis.
    Results: Of the 70 enrolled patients, 64 were analyzed, excluding 6. On multiple logistic analysis, only a water intake of 12.0 ml/min during examination [p = 0.025, odds ratio (OR): 46.753, 95% confidence interval (CI): 1.630-1341.248] was identified as an independent predictive factor involved in observation of the entire colon. With respect to factors involved in the completion of CCE within 4 h, multiple logistic analysis showed that a body mass index (BMI) of 25 (p = 0.039, OR: 13.723, 95% CI: 1.135-165.913), the absence of constipation (p = 0.030, OR: 13.988, 95% CI: 1.287-152.047), and a water intake of 12.0 ml/min during examination (p = 0.004, OR: 12.028, 95% CI: 2.225-65.029) were independent predictive factors.
    Conclusions: Completion of a CCE was most closely related to water intake per hour. In addition to water intake, CCE-promoting factors included a high BMI and the absence of constipation.

    DOI: 10.1177/1756283X16673556

    Web of Science

    PubMed

  237. Endoscopic Characteristics, Risk Grade, and Prognostic Prediction in Gastrointestinal Stromal Tumors of the Small Bowel Reviewed

    Arihiro Nakano, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto, Yoshiki Hirooka

    DIGESTION   Vol. 95 ( 2 ) page: 122 - 131   2017

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:KARGER  

    Background/Aims: Balloon-assisted endoscopy allows us to diagnose gastrointestinal (GI) stromal tumors (GISTs) in the small bowel including endoscopic ultrasonography and taking biopsy. The aim of this study was to retrospectively clarify clinical and endoscopic characteristics of small bowel GISTs using double-balloon endoscopy (DBE). Methods: We reviewed 25 patients who underwent DBE and were diagnosed with GISTs. The risk of GISTs was stratified using the National Institute of Health (NIH) consensus criteria. We evaluated the available DBE route, the diagnostic yield of biopsy examination, and the relationship between endoscopic characteristics and recurrence-free survival (RFS). Results: Of all 25 patients, 23 had any endoscopic findings related to GIST. They were detected using the antegrade approach in 91.3%. GISTs were classified into high risk (n = 7), intermediate risk (n = 4), low risk (n = 10), and very low risk (n = 4) based on surgical specimens. The diagnostic result of biopsy was 46.7% (7/15), but it was difficult to predict the NIH risk group. Endoscopic characteristics were not associated with RFS. The NIH risk group was significantly associated with RFS. Conclusions: Antegrade DBE was preferable for exploring small bowel GIST, but the diagnostic ability of biopsy examination was limited. (C) 2017 S. Karger AG, Basel

    DOI: 10.1159/000454728

    Web of Science

    PubMed

  238. Dexmedetomidine provides less body motion and respiratory depression during sedation in double-balloon enteroscopy than midazolam

    Oshima Hiroshi, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    SAGE OPEN MEDICINE   Vol. 5   page: 2050312117729920   2017

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/2050312117729920

    Web of Science

    PubMed

  239. Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis. International journal

    Atsuo Yamada, Ryota Niikura, Koutarou Maki, Masanao Nakamura, Hirotsugu Watabe, Mitsuhiro Fujishiro, Shiro Oka, Shunji Fujimori, Atsushi Nakajima, Naoki Ohmiya, Takayuki Matsumoto, Shinji Tanaka, Kazuhiko Koike, Choitsu Sakamoto

    PloS one   Vol. 12 ( 8 ) page: e0182586   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association between PPI therapy and small-bowel lesions after adjustment for the differences in baseline characteristics between users and non-users of PPIs. METHODS: We retrospectively studied patients suspected to be suffering from small-bowel diseases, who underwent capsule endoscopy between 2010 and 2013. We used propensity matching to adjust for the differences in baseline characteristics between users and non-users of PPIs. The outcomes included the prevalence of small-bowel lesions: erosion, ulcer, angioectasia, varices, and tumor. RESULTS: We selected 327 patient pairs for analysis after propensity matching, and found no significant differences in the prevalence of small-bowel injuries, including erosions and ulcers, between users and non-users of PPIs. Two subgroup analyses of the effect of the type of PPI and the effect of PPI therapy in users and non-users of nonsteroidal anti-inflammatory drugs indicated no significant differences in the prevalence of small-bowel injuries in these two groups. CONCLUSION: PPI therapy did not increase the prevalence of small-bowel injury, regardless of the type of PPI used and the use of nonsteroidal anti-inflammatory drugs.

    DOI: 10.1371/journal.pone.0182586

    Web of Science

    PubMed

  240. Risk factors for rebleeding and risk-based follow-up of obscure gastrointestinal bleeding after its initial diagnosis

    UCHIDA Genta, NAKAMURA Masanao, WATANABE Osamu, YAMAMURA Takeshi, MATSUSHITA Masanobu, ISHIKAWA Takuya, FURUKAWA Kazuhiro, FUNASAKA Kohei, OHNO Eizaburo, KAWASHIMA Hiroki, MIYAHARA Ryoji, GOTO Hidemi, HIROOKA Yoshiki

    Nippon Shokakibyo Gakkai Zasshi   Vol. 114 ( 10 ) page: 1819 - 1829   2017

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Gastroenterology  

    <p>Capsule endoscopy (CE) and double-balloon endoscopy (DBE) have revolutionized the diagnosis and treatment of obscure gastrointestinal bleeding (OGIB). Although CE and DBE provide access to the small bowel and OGIB can be effectively treated by the identification of specific bleeding lesions, some patients experience rebleeding after small bowel investigation. There are no definite algorithms to determine the best follow-up period for patients with OGIB. The purpose of this study was to investigate the long-term outcomes and risk factors for rebleeding and to develop a follow-up strategy for patients with overt OGIB. Among 386 patients who underwent CE for OGIB at Nagoya University Hospital between June 2004 and December 2015, 318 patients with overt OGIB were enrolled in this retrospective study. The clinical characteristics and risk factors for rebleeding were analyzed, and a predictive model for the same was developed. Rebleeding occurred in 45 patients (14.2%) during a median follow-up period of 16.8 months. Multivariable regression analysis identified the following factors as significant independent predictors of rebleeding:vascular lesions seen during CE, transfusion requirement, and patients aged ≥60 years. The predictive model for rebleeding was developed using these factors to identify patients who had a high risk of rebleeding and to provide useful information to physicians in clinical practice. The C-statistic of the predictive model was 0.698. A risk-based approach to follow-up patients with OGIB can help clinicians determine a follow-up period for patients after small bowel investigation.</p>

    DOI: 10.11405/nisshoshi.114.1819

    PubMed

    CiNii Research

  241. Usefulness of flexible spectral imaging color enhancement (FICE) for the detection of angiodysplasia in the preview of capsule endoscopy. Reviewed

    Nakamura M, Ohmiya N, Miyahara R, Ando T, Watanabe O, Kawashima H, Itoh A, Hirooka Y, Goto H.

    Hepatogastroenterology   Vol. 59 ( 117 ) page: 1474-1477   2012.7

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  242. Are symptomatic changes in irritable bowel syndrome correlated with the capsule endoscopy transit time? A pilot study using the 5-HT4 receptor agonist mosapride.

    Nakamura M, Ohmiya N, Miyahara R, Ando T, Watanabe O, Kawashima H, Itoh A, Hirooka Y, Niwa Y, Goto H.

      Vol. 58 ( 106 ) page: 453-458   2011.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Books 116

  1. 上皮性変化が乏しく筋層肥厚を呈した好酸球性食道炎亜型の1例

    室井航一, 古川和宏, 鈴木智彦, 廣瀬崇, 伊藤信仁, 古根聡, 角嶋直美, 中村正直, 大林友彦, 藤城光弘. 

    日本消化器内視鏡学会雑誌 

  2. 【肝門部領域胆管癌:残された問題をどう解決すべきか?】経乳頭的胆管マッピングバイオプシーの必要性と信頼性

    川嶋啓揮, 廣岡芳樹, 大野栄三郎, 石川卓哉, 田中浩敬, 酒井大輔, 飯田忠, 西尾亮, 鈴木博貴, 植月康太, 八鹿潤, 山田健太, 芳川昌功, 宜保憲明, 青木聡典, 中村正直, 宮原良二, 石上雅敏, 藤城光弘. 

    胆と膵 

  3. 大腸カプセル内視鏡におけるヒマシ油を用いた腸管洗浄の多施設共同研究

    大宮直木, 堀田直樹, 光藤章二, 中村正直, 大森崇史, 前田晃平, 奥田孝太郎, 八谷寛, 田尻久雄.

    日本消化器内視鏡学会雑誌 

  4. ダブルバルーン小腸内視鏡を用いた硬化療法にて治療効果を得た小腸多発血管腫の1例

    山田啓策, 山村健史, 中村正直, 澤田つな騎, 水谷泰之, 前田啓子, 古川和宏, 宮原良二, 横井太紀雄, 廣岡芳樹. 

    日本消化器内視鏡学会雑誌 

  5.  クローン病小腸狭窄病変に対するバルーン拡張術(4)クローン病におけるバルーン拡張術のコツ a.ダブルバルーン内視鏡の立場から

    中村正直, 山村健史, 前田啓子, 澤田つな騎, 水谷泰之, 石川恵里, 古川和宏, 角嶋直美, 藤城光弘.

    INTESTINE 

  6. 血管性病変

    澤田つな騎, 中村正直, 藤城光弘. 

    診断と治療 

  7. 【自己免疫性膵炎の最前線】自己免疫性膵炎の長期予後

    石川卓哉, 川嶋啓揮, 大野栄三郎, 飯田忠, 鈴木博貴, 植月康太, 八鹿潤, 山田健太, 芳川昌功, 宜保憲明, 青木聡典, 片岡邦夫, 森裕, 山村健史, 古川和宏, 中村正直, 石上雅敏, 藤城光弘. 

    胆と膵 

  8. 胃がんの内視鏡検診

    古川和宏, 中村正直, 藤城光弘. 

    日本消化器病学会雑誌 

  9. 【ガイドラインには書いていない胃癌治療のCQ】消化器内科医はどのような場合に心から追加胃切除を勧めるか?

    伊藤信仁, 古川和宏, 角嶋直美, 柴田寛幸, 平井恵子, 飛田恵美子, 鈴木孝弘, 鈴木智, 室井航一, 廣瀨崇, 和田啓孝, 古根聡, 中村正直, 藤城光弘. 

    臨床外科 

  10. 【薬剤性消化器疾患の診療】その他の薬剤性消化器疾患 免疫チェックポイント阻害薬による消化器障害

    伊藤隆徳, 澤田つな騎, 中村正直, 本多隆, 石上雅敏, 藤城光弘. 

    臨床消化器内科 

  11. 【除菌後胃癌を巡る課題】(3)除菌後胃癌の診断を巡って e.除菌後胃癌-診断困難例を巡って ②除菌による側方進展への影響

    伊藤信仁, 舩坂好平, 古川和宏, 角嶋直美, 中村正直, 藤城光弘. 

    臨床消化器内科 

  12. 手技の解説 Sit-stand endoscopic workstation ―人間工学から考える内視鏡, 特集/消化器領域における免疫チェックポイント 阻害薬の現状・今後の展望

    松崎一平, 服部昌志, 山本孔次郎, 榎原毅, 中村正直, 藤城光弘. 

    臨牀消化器内科 

  13. IBD治療における寛解導入と寛解維持に関するトピック (5)UC関連腫瘍の早期診断と治療

    山村健史, 中村正直, 前田啓子, 澤田つな騎, 石川恵里, 喜田裕一, 古川和宏, 川嶋啓揮, 藤城光弘. 

    臨牀消化器内科 

  14. IBD治療における寛解導入と寛解維持に関するトピック (6)IBDセンターの構想と効果,社会的役割

    中村正直, 中山吾郎, 山村健史, 服部憲史, 澤田つな騎, 佐藤雄介, 藤城光弘. 

    臨牀消化器内科  

  15. 小腸EUS 

    中村正直, 藤城光弘. 

    胃と腸 

  16. 特集:潰瘍性大腸炎診療の診断から治療をマスターする「潰瘍性大腸炎の活動性はどのように評価するのか?―内視鏡検査と検査のタイミング―」

    中村正直, 山村健史, 前田啓子, 澤田つな騎, 石川恵里, 角嶋直美, 古川和宏, 藤城光弘. 

    消化器・肝臓内科 

  17. 過誤腫性ポリポーシスの診断と治療 

    大宮直木, 中村正直, 柴田知行. 

    日本消化器内視鏡学会雑誌 

  18. 【膵管intervention】膵管カニュレーションの基本と困難例への対応

    川嶋啓揮, 大野栄三郎, 石川卓哉, 田中浩敬, 酒井大輔, 飯田忠, 西尾亮, 鈴木博貴, 植月康太, 八鹿潤, 山田健太, 芳川昌功, 中村正直, 宮原良二, 石上雅敏, 廣岡芳樹. 

    消化器・肝臓内科 

  19. 特集:消化管手術後の内視鏡(通常観察と合併症診断) 消化管手術後の小腸内視鏡

    中村正直, 大宮直木, 丹羽康正, 後藤秀実. 

    Modern Physician 

  20. カプセル内視鏡検査の診断能改善の工夫

    中村正直, 丹羽康正, 大宮直木, 本田亘, 児玉佳子, 白井修, 伊藤彰浩, 廣岡芳樹, 後藤秀実. 

    消化器科 

  21.  特集Ⅰ ダブルバルーン内視鏡の手技の工夫と応用 ダブルバルーン内視鏡の診断・治療手技の工夫

    本田亘, 大宮直木, 中村正直, 白井修, 丹羽康正, 前田修, 安藤貴文, 後藤秀実.

    消化器科 

  22. 何を?いつ?がひとめでわかる 術後72時間の要観察ポイント8 下部消化管EMR後72時間

    白井修, 大宮直木, 中村正直, 本田亘, 前田修, 安藤貴文, 後藤秀実. 

    消化器外科NURSING 

  23. 特集:消化管手術後の内視鏡(通常観察と合併症診断) 消化管手術後の小腸内視鏡

    中村正直, 丹羽康正, 大宮直木, 宮原良二, 松浦哲生, 荒川大吾, 井口洋一, 本田亘, 児玉佳子, 白井修, 舩坂好平, 安藤貴文, 前田修, 伊藤彰浩, 大宮直木, 廣岡芳樹, 後藤秀実. 

    消化器内視鏡 

  24. 特集:ダブルバルーン内視鏡が変えた治療学 小腸ポリープのポリペクトミーのコツ

    本田亘, 大宮直木, 中村正直, 白井修, 丹羽康正, 前田修, 安藤貴文, 後藤秀実. 

    消化器内視鏡 

  25. 2.小腸炎症疾患 2)腸結核

    中村正直, 大宮直木, 本多亘, 白井修, 竹中宏之, 丹羽康正, 大宮直木, 後藤秀実. 

    胃と腸 

  26. 3.小腸出血診断のアルゴリズム

    大宮直木, 中村正直, 本多亘, 白井修, 竹中宏之, 倉橋正明, 伊藤彰浩, 廣岡芳樹, 丹羽康正, 前田修, 安藤貴文, 後藤秀実. 

    胃と腸 

  27. カプセル内視鏡の有用性

    中村正直, 丹羽康正, 大宮直木, 後藤秀実. 

    癌と科学療法 

  28. 症例 クローン病の腸管狭窄に対する内視鏡的拡張術

    竹中宏之, 大宮直木, 中村正直, 白井修, 森島賢治, 宮原良二, 渡辺修, 安藤貴文, 丹羽康正, 後藤秀実. 

    治療学 Biomedicine&therapeutics 

  29. 特集:今や常識 小腸内視鏡-カプセルとバルーン内視鏡の最新知識- カプセル内視鏡とバルーン内視鏡の使い分け

    大宮直木, 中村正直, 本田亘, 白井修, 竹中宏之, 森島賢治, 宮原良二, 丹羽康正, 渡辺修, 安藤貴文, 後藤秀実. 

    消化器内視鏡 

  30. Meckel憩室と消化管重複症.

    白井修, 大宮直木, 中村正直

    日本臨牀 

  31. 小腸の内視鏡所見 第9回 NSAIDs潰瘍

    山村健史, 大宮直木, 中村正直, 白井修, 竹中宏之, 森島賢治, 宮原良二, 渡辺修, 安藤貴文,後藤秀実. 

    Frontiers in Gastroenterology 

  32. 特集 小腸疾患に対する最新のアプローチ Ⅳ [各論-疾患ごとのアプローチを考える] 小腸潰瘍性病変 (3)NSAIDs起因性潰瘍 a.ダブルバルーン内視鏡を中心に

    山村健史, 大宮直木, 中村正直, 白井修, 竹中宏之, 森島賢治, 宮原良二, 安藤貴文, 後藤秀実. 

    INTESTINE 

  33. 主題研究 小さな小腸病変に対するカプセル内視鏡, ダブルバルーン内視鏡, 小腸X線の診断能の比較

    大宮直木, 中村正直, 白井修, 竹中宏之, 森島賢治, 山村健史, 宮原良二, 渡辺修, 安藤貴文, 丹羽康正, 後藤秀実. 

    胃と腸 

  34. 主題 小腸の小病変の診断機器の進歩とアルゴリズム

    後藤秀実, 中村正直. 

    胃と腸 

  35. 特集Ⅰ カプセル内視鏡の進歩と有用性 小腸用カプセル内視鏡による大腸観察の試み

    中村正直, 丹羽康正, 大宮直木, 宮原良二, 安藤貴文, 渡辺修,川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 後藤秀実. 

    消化器・肝臓内科 

  36. 特集・薬剤による消化管出血 薬剤による消化管出血患者の管理・フォローアップ実際

    中村正直, 大宮直木, 白井修, 竹中宏之, 森島賢治, 宮原良二, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 渡辺修, 安藤貴文, 後藤秀実. 

    消化器の臨床 

  37. 主題1 小腸の内視鏡診断と治療-カプセル内視鏡を含めて- カプセル内視鏡を用いた大腸蠕動運動の定量化の試み -過敏性腸症候群の客観的評価に向けて-

    中村正直, 丹羽康正, 大宮直木, 宮原良二, 白井修, 竹中宏之, 森島賢治, 渡辺修, 安藤貴文,川嶋啓揮, 伊藤彰浩, 廣岡芳樹, (藤本英雄, 八木橋信,)後藤秀実. 

    消化器医学 

  38. ●癌や炎症と識別が困難な消化管悪性リンパ腫● 癌や炎症と識別困難な十二指腸・小腸悪性リンパ腫 内視鏡診断を中心に

    丹羽康正, 中村正直, 大宮直木, 森島賢治, 白井修, 宮原良二, 安藤貴文, 後藤秀実. 

    消化器外科NURSING  

  39. 特集 2部 手術以外の主な治療 7.下部消化管の内視鏡的粘膜切除術(EMR)・内視鏡的粘膜下層剥離術(ESD)

    白井修, 大宮直木, 中村正直, 竹中宏之, 森島賢治, 山村健史, 渡辺修, 安藤貴文, 後藤秀実. 

    消化器外科NURSING  

  40. 小腸腫瘍の診断と内視鏡ポリペクトミーのコツ

    大宮直木, 中村正直, 白井修, 竹中宏之, 森島賢治, 山村健史, 宮原良二,川嶋啓揮、伊藤彰浩、廣岡芳樹、 渡辺修、安藤貴文、丹羽康正、後藤秀実

    日本消化器内視鏡学会雑誌 

  41. 特集/小腸・大腸疾患-診断のめざましい進歩 小腸-小腸疾患診断のコツ 炎症性疾患-Crohn病, 腸結核

    中村正直, 大宮直木, 白井修, 竹中宏之, 森島賢治, 宮原良二, 安藤貴文, 渡辺修,川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 後藤秀実. 

    臨牀と研究 

  42. 特集 見えてきた小腸病変 血管病変

    中村正直, 大宮直木, 後藤秀実. 

    Jounal of Gastrointestinal Reseach(G.I.Reseach)12 

  43. 特集:実践的カプセル内視鏡 小腸用カプセル内視鏡の検査法と読影法の工夫

    山村健史, 大宮直木, 中村正直, 竹中宏之, 森島賢治, 石原誠, 宮原良二, 渡辺修, 安藤貴文,川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 後藤秀実. 

    胃と腸 

  44. 主題 過誤腫性ポリポーシス Puetz-Jeghers症候群の長期経過

    大宮直木, 中村正直, 竹中宏之, 森島賢治, 石原誠, 小原圭, 水谷太郎, 山村健史, 宮原良二, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 渡辺修, 安藤貴文, 後藤秀実. 

    胃と腸 

  45.  |特集|抗血栓療法と消化管障害 8.アスピリンと小腸粘膜傷害

    石原誠, 大宮直木, 中村正直, 後藤秀実.

    血栓と循環 THROMBOSIS and Circulation 

  46. NSAIDs・アスピリンによる粘膜傷害のマネージメント-[小腸] [トピックス]予防・治療薬研究の現状と展開 レバミピド

    中村正直, 大宮直木, 竹中宏之, 森島賢治, 石原誠, 宮原良二, 渡辺修,前田修, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 安藤貴文, 丹羽康正, 後藤秀実.

    消化器の臨床 

  47. 特集5 消化器外科ナースのための疾患別ケア 胃潰瘍

    鶴留一誠, 宮原良二, 舩坂好平, 坂野閣紀, 中村正直, 川嶋啓揮, 伊藤彰浩, 大宮直木, 廣岡芳樹, 後藤秀実. 

    消化器外科NURSING2010 

  48. 特集3 消化器外科ナースのための疾患別ケア 逆流性食道炎

    鶴留一誠, 宮原良二, 舩坂好平, 坂野閣紀, 中村正直, 川嶋啓揮, 伊藤彰浩, 大宮直木, 廣岡芳樹, 後藤秀実. 

    消化器外科NURSING2010 

  49. 特集:実践的カプセル内視鏡 小腸用カプセル内視鏡の検査法と読影法の工夫

    中村正直, 大宮直木, 竹中宏之, 森島賢治, 石原誠, 宮原良二, 前田修, 渡辺修,川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 安藤貴文, 後藤秀実. 

    消化器内視鏡 

  50. 特集◆やっぱり大切, 基本手技 カプセル内視鏡読影の基本-PillCam

    中村正直, 大宮直木, 後藤秀実. 

    消化器内視鏡 

  51. やっぱり大切, 基本手技 Ⅱ.小腸[診断・治療]カプセル内視鏡読影の基本-PillCam

    中村正直, 大宮直木, 後藤秀実.

    消化器内視鏡 

  52. NSAID起因性小腸病変のカプセル内視鏡による前向き評価

    石原誠, 大宮直木, 中村正直, 竹中宏之, 森島賢治, 小原圭, 水谷太郎, 山村健史, 宮原良二, 渡辺修, 安藤貴文, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 後藤秀実. 

    胃と腸 

  53. カプセル内視鏡における読影法

    中村正直,後藤秀実. 

    日本消化器内視鏡学会雑誌 

  54. 特集:NSAIDs潰瘍 NSAIDs 小腸粘膜傷害の診断と臨床的特徴

    中村正直, 大宮直木, 後藤秀実. 

    日本臨牀 

  55. 特集:トラブルを防ぐ!下部消化管内視鏡 挿入法のコツ・検査のポイント 【小腸内視鏡】カプセル内視鏡検査の方法と読影のポイント

    中村正直, 大宮直木, 山村健史, 水谷太郎, 石原誠, 山田弘志, 名倉明日香, 吉村透, 舩坂好平, 宮原良二, 安藤貴文, 前田修, 渡辺修, 大野栄三郎, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 後藤秀実. 

    消化器の臨床 

  56. 特集:バルーン内視鏡のすべて バブルバルーン小腸内視鏡〔バルーン内視鏡の挿入法〕

    大宮直木, 中村正直, 山村健史, 水谷太郎, 石原誠, 山田弘志, 名倉明日香, 舩坂好平, 大野栄三郎, 宮原良二, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 渡辺修, 安藤貴文, 後藤秀実. 

    消化器内視鏡 

  57. 特集 内視鏡検査・治療時の管理は? 2.小腸内視鏡  (1)小腸内視鏡検査時の前処置と前投薬

    山田弘志, 大宮直木, 中村正直, 後藤秀実. 

    臨牀消化器内科 

  58. 特集 カプセル・バルーン内視鏡の新展開 [カプセル内視鏡編] (2) パテンシーカプセルの有用性とクローン病への応用

    吉村透, 大宮直木, 中村正直, 山村健史, 山田弘志, 名倉明日香, 中野有泰, 大島啓嗣, 後藤秀実. 

    INTESTINE 

  59. カプセル内視鏡を用いたクローン病小腸病変の評価

    中村正直, 大宮直木, 後藤秀実.

    クリニシアン 

  60.  ●カプセル内視鏡の現状と展望● 主題 カプセル内視鏡が診断に有用な疾患

    中村正直, 大宮直木, 廣岡芳樹, 山村健史, 水谷太郎, 石原誠, 山田弘志, 名倉明日香, 宮原良二, 舩坂好平, 伊藤彰浩, 川嶋啓揮, 大野栄三郎, 安藤貴文, 渡辺修, 後藤秀実.

    胃と腸 

  61. Crohn病診断におけるカプセル内視鏡

    大宮直木, 中村正直, 山村健史, 水谷太郎, 石原誠, 山田弘志, 名倉明日香, 吉村透, 舩坂好平, 宮原良二, 大野栄三郎, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 渡辺修, 安藤貴文, 後藤秀実. 

    胃と腸 

  62. 非腫瘍性大腸ポリポーシス

    名倉明日香, 大宮直木, 中村正直, 山村健史, 水谷太郎, 石原誠, 山田弘志, 吉村透, 舩坂好平, 宮原良二, 大野栄三郎, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 安藤貴文, 後藤秀実. 

    胃と腸 

  63. 原因不明消化管出血におけるカプセル内視鏡とバルーン内視鏡の有用性

    吉村透, 大宮直木, 中村正直, 水谷太郎, 山村健史, 石原誠, 山田弘志, 名倉明日香, 舩坂好平, 大野栄三郎, 宮原良二, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 渡辺修, 安藤貴文, 後藤秀実. 

    消化器内科 

  64. 特集:症例に学ぶ類似病変 Peutz-Jeghers病候群

    中村正直, 山村健史, 後藤秀実. 

    消化器内視鏡 

  65. 小腸疾患の臨床 Ⅲ各論 3, 炎症性疾患 2. 腸結核

    中村正直, 大宮直木, 廣岡芳樹, 山村健史, 山田弘志, 名倉明日香, 吉村透, 宮原良二, 舩坂好平, 後藤秀実. 

    臨牀消化器内科 

  66. 消化管原発 aggressive lymphoma-diffuse large B-cell lymphoma 小腸・大腸DLBCLの診断と治療

    中村正直, 大宮直木, 山村健史, 名倉明日香, 吉村透, 中野有泰, 大島啓嗣, 古川和宏, 舩坂好平, 宮原良二, 大野栄三郎, 川嶋啓揮, 廣岡芳樹, 渡辺修, 安藤貴文, 後藤秀実. 

    胃と腸 

  67. 特集:小腸の炎症 Ⅱ.各論 (2)感染性炎症性疾患 c.腸結核

    山村健史, 中村正直, 渡辺修, 古川和宏, 舩坂好平, 宮原良二, 安藤貴文, 廣岡芳樹, 後藤秀実. 

    INTESTINE 

  68. 当院でダブルバルーン内視鏡検査を施行した虚血性小腸炎の検討

    佐藤淳一, 中村正直, 渡辺修, 後藤秀実. 

    消化と吸収 

  69. 特集/カプセル内視鏡の現況と最新動向 3.パテンシーカプセル (1)消化管開通性評価に影響する因子

    山村健史, 中村正直, 渡辺修, 澤田つな騎, 廣岡芳樹, 後藤秀実. 

    臨牀 消化器内科 

  70. 転移性消化管腫瘍―肺癌の小腸転移

    中村正直, 大宮直木, 後藤秀実.

    消化器内視鏡 

  71. 抗結核薬による診断的治療が奏功した小腸多発潰瘍の1例

    齋藤雅之, 中村正直, 渡辺修,山村健史,松下正伸,中野有泰,大島啓嗣, 佐藤淳一, 松浦倫三郎,舩坂好平, 大野栄三郎, 川嶋啓揮, 宮原良二, 廣岡芳樹, 後藤秀実.

    胃と腸 

  72. 小腸出血, 内視鏡データリファレンスブック

    中村正直, 廣岡芳樹, 渡辺修, 山村健史, 後藤秀実. 

    消化器内視鏡 

  73. 枠組みとケースから考えられる消化器薬の選び方・使い方(腹痛・体重減少-Crohn病)

    山村健史, 中村正直, 廣岡芳樹. 

    medicina 

  74. 知っておこう! 遺伝性消化器疾患 Peutz-Jeghers症候群

    中村正直, 大宮直木, 廣岡芳樹, 後藤秀実.

    消化器内視鏡 

  75. 薬剤と小腸粘膜障害,小腸出血との関連:多施設カプセル内視鏡研究

    新倉量太, 山田篤生, 馬來康太郎, 中村正直, 渡部宏嗣, 藤城光弘, 岡志郎, 江崎幹宏, 藤森俊二, 中島淳, 大宮直木, 松本主之, 田中信治, 小池和彦, 坂本長逸

    日本消化器内視鏡学会雑誌 

  76. 炎症性腸疾患増刊号 小腸カプセル内視鏡

    中村正直, 大宮直木, 廣岡芳樹, 後藤秀実.

    日本臨牀  

  77. 緊急カプセル内視鏡・バルーン内視鏡を可能にする体制作りと実際の運用

    山村健史、中村正直、前田啓子、澤田つな騎, 古川和宏, 宮原良二, 川嶋啓揮, 藤城光弘.

    INTESTINE  

  78. カプセル内視鏡診断におけるAIへの期待

    中村正直. 

    Precision Medicine  

  79. 消化器疾患における緊急内視鏡の果たす役割

    古根聡, 古川和宏, 宮原良二, 伊藤隆徳, 澤田つな騎, 前田啓子, 山村健史, 石川卓哉, 石津洋二, 大野栄三郎, 中村正直, 本多隆, 石上雅敏, 川嶋啓揮, 藤城光弘.

    消化管・肝臓内科 

  80. クリニカルトピックス「小腸内視鏡(カプセル内視鏡)」

    丹羽康正, 中村正直, 後藤秀実. 

    BIO Clinica 

  81. Ⅱ.各論「5.小腸病変-4ポリープ・ポリポーシス」Case28 カプセル内視鏡診療ガイド, 寺野彰他(編集), p92-93

    丹羽康正, 中村正直, 後藤秀実. 

    南江堂 

  82. symposium:カプセル内視鏡を用いた過敏性腸症候群診断の可能性 THERAPEUTIC RESEACH 2007.4.20発行 Vol.28 別刷,p636-637

    中村正直, 丹羽康正, 宮原良二, 松浦哲生, 荒川大吾, 井口洋一, 本田亘, 児玉佳子, 伊藤彰浩, 大宮直木, 廣岡芳樹, 後藤秀実. 

    THERAPEUTIC RESEACH 

  83. 特集:小腸疾患 Meckel憩室と消化管重複症 日本臨床 第66巻・第7号 別刷, p1343-1349

    白井修, 大宮直木, 中村正直, 本田亘, 竹中宏之, 浜島英司, 井本正巳, 後藤秀実. 

    日本臨床社 

  84.  特集:小腸疾患 内視鏡検査 -カプセル内視鏡とダブルバルーン小腸内視鏡- 日本臨床 第66巻・第7号 別刷, p1253-1258

    中村正直, 大宮直木, 丹羽康正, 後藤秀実.

    日本臨床社 

  85.  プラクティス編 X 5. NSAIDs, アスピリンの下部消化管病変をどう予防する? 薬剤性消化管傷害 NSAIDs・アスピリンをめぐるエビデンスとプラクティス, 坂本 長逸(編集), p156-160

    中村正直, 後藤秀実.

    南江堂 

  86. 第Ⅱ部 画像読影法の基本とレーニング ②画像読影の基本 a.読影の進め方 カプセル内視鏡スタンダードテキスト 初心者,コメディカルにも役立つ, 寺尾彰(監修), p23-25

    中村正直, 後藤秀実. 

    南江堂 

  87. 基本編・応用編04 小腸結核 これで納得!画像で見ぬく消化器疾患 vol.3 小腸, 大塚和朗(編集), p68-72

    名倉明日香, 中村正直, 後藤秀実. 

    医学出版 

  88. 基礎編03 転移性小腸癌 これで納得!画像で見ぬく消化器疾患 vol.3 小腸, 大塚和朗(編集), p108-111

    名倉明日香, 中村正直, 後藤秀実. 

    医学出版 

  89. 3.読影の基本とポイント 1)カプセル内視鏡に関連する消化管の解剖 動画でわかるカプセル内視鏡テキスト, 日本カプセル内視鏡学会(JACE)アトラス作成委員会 (監修・編集), p34-38

    中村正直, 後藤秀実. 

    コンパス出版局 

  90. 3.読影の基本とポイント 3)食道, 胃の所見 動画でわかるカプセル内視鏡テキスト, 日本カプセル内視鏡学会(JACE)アトラス作成委員会 (監修・編集), p50-53

    中村正直, 後藤秀実. 

    コンパス出版局 

  91. I.症候 吐血・下血 消化器病診療 第2版, 一般財団法人 日本消化器病学会(監修), 「消化器病診療(第2版)」 編集委員会(編集),  p7-10

    宮原良二, 中村正直, 後藤秀美. 

    医学書院 

  92. 第2章治療薬の使い方 コツと落とし穴 §1薬物治療 11抗菌薬 チェックリストでわかる!IBD治療薬の選び方・使い方 重症度と患者背景から導く炎症性腸疾患の処方, 日比紀文(監修), 小林拓, 新崎信一郎(編集), p106-110

    渡辺修, 中村正直, 後藤秀実. 

    羊土社 

  93. 第8章IBDカプセル内視鏡 2 カプセル内視鏡前の消化管開通性評価 実臨床に役立つIBD内視鏡-判断・モニタリング・サーベイランス-,日比 紀文 , 山本 博徳 (監修) ,久松 理一 ,矢野 智則(編集)

    中村正直, 大宮直木, 後藤秀実. 

    日本メディカルセンター 

  94. 4章クローン病のImaging Atlas 2 クローン病典型例 小腸病変(内視鏡・カプセル) 炎症性腸疾患Imaging Atlas -診断の極意と鑑別のポイント- p110-113

    中村正直, 渡辺修, 後藤秀実. 

    日本メディカルセンター 

  95.  消化管疾患 【C.腸】12.mid-Gl bleeding 消化器疾患 最新の治療 2019-2020, 小池和彦,

    中村正直, 廣岡芳樹.

    南江堂 

  96. 第4章 消化管疾患 腸疾患 小腸癌 医学書院「新臨床内科学 第10版」,矢﨑 義雄 (監修), p560-561

    中村正直. 

    医学書院 

  97. 第4章 消化管疾患 腸疾患 小腸・大腸良性腫瘍 医学書院「新臨床内科学 第10版」,矢﨑 義雄 (監修), p561-562

    中村正直.

    医学書院 

  98.  Ⅵ空腸,回腸,盲腸,結腸,直腸(上) 4.吸収不良・蛋白漏出 腸リンパ管拡張症 別冊 日本臨牀 領域別症候群シリーズNo.11 消化管症候群(第3版)(Ⅲ)―その他の消化管疾患を含めて― 序文 空腸,回腸,盲腸,結腸,直腸(上), p290 

    中村正直, 山村健史, 藤城光弘.

    日本臨床社 

  99. 十二指腸 脈管性病変 リンパ管拡張症 医学書院 上部消化管 内視鏡診断アトラス, 長浜隆司, 竹内学(編集), p208-209

    中村正直. 

    医学書院 

  100. 小腸 脈管性病変 リンパ管拡張症 医学書院 下部消化管 内視鏡診断アトラス, 松本主之(編集), p30-31

    中村正直. 

    医学書院 

  101.  各論V消化器関連 Q28炎症性腸疾患 救急・集中治療 Vol.32 No.3, 特集 ER・ICUでの薬の使い方・考え方~エキスパートが実践する秘訣(コツ)~2021-22, 松田直之(編集), p795-800

    松下正伸, 中村正直, 藤城光弘.

    総合医学社 

  102. Ⅲ消化管疾患 C.腸 8.腸結核 消化器疾患 最新の治療 2021-2022, 小池和彦,山本博徳,瀬戸泰之(編集)

    中村正直, 藤城光弘. 

    南江堂 

  103. IL-12/IL-23阻害薬 クローン病 クリニコ出版 生物学的製剤適正使用ガイド 病態理解に沿った治療選択2021, 藤尾圭志(編集), p158-165

    村手健太郎, 中村正直, 藤城光弘. 

    クリニコ出版 

  104. 光学的干渉断層法を用いたダブルバルーン小腸内視鏡検査の有用性

    大宮直木, 荒川大吾, 中村正直, 本田亘, 金沢宏信, 田口歩, 馬渕信行, 尾関雅靖, 長谷川太作, 小林拓, 倉橋正明, 廣岡芳樹, 丹羽康正, 後藤秀実. 

    胃と腸 

  105. 特集:消化管疾患の診断と治療-最新の進歩- 内視鏡診断の進歩 カプセル内視鏡

    中村正直, 丹羽康正, 大宮直木, 後藤秀実. 

    最新医学 

  106. ダブルバルーン内視鏡による小腸疾患の診断

    大宮直木, 田口歩, 荒川大吾, 山田雅弘, 中村正直, 尾関雅靖, 馬渕信行, 金沢宏信, 長谷川太作, 小林拓, 倉橋正明, 伊藤彰浩, 廣岡芳樹, 丹羽康正, 後藤秀実. 

    消化器内視鏡 

  107.  特集:緊急内視鏡検査と治療 緊急内視鏡検査と小腸疾患

    中村正直, 丹羽康正, 大宮直木, 後藤秀実.

    臨牀消化器内科 

  108. 2. 良性腫瘍に対する内視鏡治療 2)小腸

    大宮直木, 荒川大吾, 本田亘, 中村正直, 田口歩, 馬渕信行, 尾関雅靖, 金沢宏信, 長谷川太作, 小林拓, 倉橋正明, 松山泰士, 多々内暁光, 山本英子, 丹羽康正, 後藤秀実. 

    胃と腸 

  109. 小腸疾患診療の新たな展開 主題 「Crohn病に対する小腸内視鏡の有用性」

    大宮直木, 荒川大吾, 中村正直, 本田亘, 田口歩, 金沢宏信, 長谷川太作, 小林拓, 倉橋正明, 多々内暁光, 山本英子, 松山恭士, 伊藤彰浩, 廣岡芳樹, 丹羽康正, 後藤秀実. 

    胃と腸 

  110. 小腸疾患の診断・治療におけるダブルバルーン小腸内視鏡の有用性

    中村正直, 後藤秀実. 

    消化器医学 

  111. ダブルバルーン内視鏡

    大宮直木, 荒川大吾, 中村正直, 本田亘, 後藤秀実. 

    消化器内視鏡 

  112. 特集:今できる小腸疾患へのアプローチ 「小腸疾患の診断および治療におけるカプセル内視鏡とダブルバルーン内視鏡」

    大宮直木, 荒川大吾, 中村正直, 本田亘, 白井修, 田口歩, 伊藤彰浩, 廣岡芳樹, 丹羽康正, 後藤秀実. 

    消化器内視鏡 

  113. カプセル内視鏡

    丹羽康正, 中村正直, 大宮直木, 後藤秀実. 

    明日の臨床 

  114. 特集:神経内分泌細胞腫瘍 6.小腸カルチノイドの病態・診断・治療

    中村正直, 大宮直木, 荒川大吾, 本田亘, 丹羽康正, 後藤秀実. 

    臨床消化器内科 

  115. 内視鏡の新しい展開-照明光の特性と内視鏡

    丹羽康正, 中村正直, 大宮直木, 後藤秀実. 

    臨牀消化器内科 

  116. 特集 神経内分泌細胞腫瘍 6.小腸カルチノイドの病態・診断・治療

    中村正直, 大宮直木, 荒川大吾, 本田亘, 丹羽康正, 後藤秀実. 

    臨牀消化器内科 

▼display all

MISC 10

  1. Clinical Factors Related to False Positive Rates of Patency Capsule Examination

    Tsunaki Sawada, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Masanobu Matsushita, Hiroshi Oshima, Junichi Sato, Masashi Saito, Rinzaburo Matsuura, Yasuyuki Mizutani, Yoshiki Niwa, Eri Ishikawa, Genta Uchida, Hiroyuki Otsuka, Hiroto Suzuki, Takahiro Nishikawa, Tetsuya Ishida, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Ryoji Miyahara, Hiroki Kawashima, Hidemi Goto, Yoshiki Hirooka

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB305 - AB305   2017.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:MOSBY-ELSEVIER  

    Web of Science

  2. The Study of Diagnostic Ability for the Colorectal Neoplasms by Imaged Enhanced Endoscopy Using by JNET (Japan NBI Expert Team) Classification

    Takeshi Yamamura, Osamu Watanabe, Masanao Nakamura, Masanobu Matsushita, Hiroshi Oshima, Junichi Sato, Rinzaburo Matsuura, Masashi Saito, Yasuyuki Mizutani, Tsunaki Sawada, Yoshiki Niwa, Eri Ishikawa, Genta Uchida, Hiroyuki Otsuka, Hiroto Suzuki, Takahiro Nishikawa, Tetsuya Ishida, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB402 - AB402   2017.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:MOSBY-ELSEVIER  

    Web of Science

  3. The Outcome of Treatment in Hypopharyngeal and Cervical Esophageal Carcinoma

    Toshihisa Fujiyoshi, Ryoji Miyahara, Kohei Funasaka, Kazuhiro Furukawa, Masanobu Matsushita, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Osamu Watanabe, Yoshiki Hirooka, Hidemi Goto

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB597 - AB598   2017.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:MOSBY-ELSEVIER  

    Web of Science

  4. Predicting the Depth of Invasion of Esophageal Squamous Cell Carcinoma: Under Experience of Linked Colored Imaging With LED Light Source

    Kenichi Kobayashi, Ryoji Miyahara, Kohei Funasaka, Kazuhiro Furukawa, Masanobu Matsushita, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Osamu Watanabe, Yoshiki Hirooka, Hidemi Goto

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB527 - AB527   2017.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:MOSBY-ELSEVIER  

    Web of Science

  5. One Year Follow-Up After Cold Polypectomy Compared With Hot Polypectomy for Small Colorectal Polyps - a Prospective Randomized Controlled Trial

    Masashi Saito, Takeshi Yamamura, Osamu Watanabe, Masanao Nakamura, Masanobu Matsushita, Hiroshi Oshima, Junichi Sato, Rinzaburo Matsuura, Yasuyuki Mizutani, Tsunaki Sawada, Yoshiki Niwa, Eri Ishikawa, Genta Uchida, Hiroyuki Otsuka, Hiroto Suzuki, Takahiro Nishikawa, Tetsuya Ishida, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto, Yoshiki Hirooka

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB365 - AB366   2017.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:MOSBY-ELSEVIER  

    Web of Science

  6. Objective Assessment of Jejunal Villous Blood Flow for Evaluating Pancreas-Jejunum Functional Correlation Using a Novel Image Analyzing System

    Tomoaki Takeyama, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Manabu Kawai, Hiroki Suhara, Kiyotaka Hashizume, Toshinari Koya, Hiroyuki Tanaka, Daisuke Sakai, Masanobu Matsushita, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Hidemi Goto

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB319 - AB320   2017.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:MOSBY-ELSEVIER  

    Web of Science

  7. Novel EMR Technique for Preoperative Diagnosis and Treatment of Submucosal Tumor in the Small Bowel at Double-Balloon Endoscopy

    Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Masanobu Matsushita, Hiroshi Oshima, Junichi Sato, Masashi Saito, Rinzaburo Matsuura, Yasuyuki Mizutani, Tsunaki Sawada, Yoshiki Niwa, Eri Ishikawa, Genta Uchida, Hiroyuki Otsuka, Hiroto Suzuki, Takahiro Nishikawa, Tetsuya Ishida, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto, Yoshiki Hirooka

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB300 - AB300   2017.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:MOSBY-ELSEVIER  

    Web of Science

  8. New Comorbidity Index Associated With Vascular Disease and Rebleeding in Small Bowel Bleeding

    Naoki Ohmiya, Masanao Nakamura, Tomomitsu Tahara, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Hidemi Goto

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB427 - AB428   2017.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:MOSBY-ELSEVIER  

    Web of Science

  9. Establishment of a New Scoring System for Predicting the Necessity of Double-Balloon Endoscopy in Obscure Gastrointestinal Bleeding

    Genta Uchida, Osamu Watanabe, Masanao Nakamura, Takeshi Yamamura, Masanobu Matsushita, Hiroshi Oshima, Junichi Sato, Masashi Saito, Rinzaburo Matsuura, Yasuyuki Mizutani, Tsunaki Sawada, Yoshiki Niwa, Eri Ishikawa, Hiroyuki Otsuka, Hiroto Suzuki, Takahiro Nishikawa, Tetsuya Ishida, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto, Yoshiki Hirooka

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB300 - AB300   2017.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:MOSBY-ELSEVIER  

    Web of Science

  10. NATURAL HISTORY OF PANCREATIC CYSTIC LESIONS: MID-TERM ANALYSIS OF A MULTICENTER PROSPECTIVE OBSERVATORY STUDY FOCUSING THE RISK OF PANCREATIC CANCER

    Eizaburo Ohno, Yoshiki Hirooka, Hiroki Kawashima, Manabu Kawai, Hiroki Suhara, Tomoaki Takeyama, Takuya Ishikawa, Kiyotaka Hashizume, Toshinari Koya, Daisuke Sakai, Hiroyuki Tanaka, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Hidemi Goto

    GASTROENTEROLOGY   Vol. 152 ( 5 ) page: S147 - S147   2017.4

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:W B SAUNDERS CO-ELSEVIER INC  

    Web of Science

▼display all

Presentations 107

  1. 分子標的時代における炎症性腸疾患診療について

    中村正直

    日本消化器病学会東海支部第44回教育講演会  2020.11.28 

     More details

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  2. 小腸疾患の内視鏡診断と治療

    中村正直

    第32回 日本消化器内視鏡学会東海セミナー  2021.1.17 

     More details

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  3. 小腸内視鏡を用いた小腸疾患の診断と治療 ―現在のトレンド―

    中村正直

    日本消化器内視鏡学会東海支部ガイドライン研修会  2019.7.7 

     More details

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  4. 大腸カプセル内視鏡の普及に向けた工夫 「大腸カプセル内視鏡によるクローン病診断への応用に向けて」

    中村正直, 山村健史, 前田啓子, 澤田つな騎, 水谷泰之, 石川恵里, 角嶋直美, 古川和宏, 藤城光弘

    第14回日本カプセル内視鏡学会学術集会  2021.2.22 

  5. 消化管原発diffuse large B-cell lymphomaにおけるdouble-expressor lymphomaの臨床病理学的検討

    石川恵里, 中村正直, 藤城光弘

    第101回日本消化器内視鏡学会総会  2021.5.14 

  6. ダブルバルーン内視鏡で診断された虚血性小腸炎の臨床的特徴

    中村正直, 山村健史, 藤城光弘

    第101回日本消化器内視鏡学会総会  2021.5.14 

     More details

    Presentation type:Symposium, workshop panel (public)  

  7. クローン病の小腸狭窄に対するバルーン内視鏡下バルーン拡張術の治療成績

    池上脩二, 中村正直, 藤城光弘

    第101回日本消化器内視鏡学会総会  2021.5.16 

     More details

    Presentation type:Symposium, workshop panel (public)  

  8. ビデオワークショップ1「術後消化管に対する内視鏡診断と治療」術後小腸に対するカプセル内視鏡とダブルバルーン内視鏡のコンビネーションアプローチ

    中村正直, 丹羽康正, 大宮直木

    第71回日本消化器内視鏡学会総会  2006.5.16 

     More details

    Presentation type:Symposium, workshop panel (public)  

  9. ワークショップⅡ「新しい画像診断による消化器がん検診(PET、 CTなど)」カプセル内視鏡を用いた大腸癌検診の試み

    中村正直, 丹羽康正, 後藤秀実

    第45回日本消化器がん検診学会  2006.5.6 

     More details

    Presentation type:Symposium, workshop panel (public)  

  10. ビデオワークショップ1 (消化器内視鏡学会・消化器病学会・消化器がん検診学会合同) カプセル内視鏡における診断能改善の工夫「カプセル内視鏡における診断能改善の工夫」

    中村正直, 丹羽康正, 後藤秀実

    第72回日本消化器内視鏡学会総会(DDW-Japan2006)  2006.10.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

  11. 内W19-7 小腸用カプセル内視鏡による大腸観察の試み

    中村正直, 丹羽康正, 後藤秀実

    JDDW2007  2007.10.21 

  12. SP-WS-6 原因不明の消化管出血におけるカプセル内視鏡の診断能

    中村正直, 大宮直木, 白井修, 竹中宏之, 森島賢治, 宮原良二, 安藤貴文, 渡辺修, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 丹羽康正, 後藤秀実

    第5回日本消化管学会総会学術集会  2009.2.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

  13. W10-3 消化管ポリポーシスの診断とフォローアップにおけるカプセル内視鏡の有用性

    中村正直, 大宮直木, 後藤秀実

    第77回日本消化器内視鏡学会総会  2009.5.22 

     More details

    Presentation type:Symposium, workshop panel (public)  

  14. 内W9-1 カプセル内視鏡全陽性所見の検討―層別化による臨床効果―

    中村正直, 大宮直木, 後藤秀実

    JDDW2009  2009.10.15 

  15. WS-1-7 濾胞性リンパ腫小腸病変の診断とフォローアップにおけるカプセル内視鏡、ダブルバルーン内視鏡の有用性

    中村正直, 大宮直木, (白井修), 竹中宏之, 森島賢治, 宮原良二, 安藤貴文, 渡辺修, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 後藤秀実

    第6回日本消化管学会総会学術集会  2010.2.20 

     More details

    Presentation type:Symposium, workshop panel (public)  

  16. Peutz-Jeghers症候群(PJS)の小腸ポリポーシスに対する小腸X線、ダブルバルーン内視鏡(VCE)を用いた診療策略

    大宮直木, 中村正直, 後藤秀美

    第80回日本消化器内視鏡学会総会  2010.10.16 

     More details

    Presentation type:Symposium, workshop panel (public)  

  17. W4-10 カプセル内視鏡至適読影モードに関する検討

    中村正直, Chris Fraser

    第83回日本消化器内視鏡学会総会  2012.5.13 

  18. 85-WS-消03 通常型膵癌と膵神経内分泌腫瘍のEUSによる鑑別

    伊藤裕也, 廣岡芳樹, 伊藤彰浩, 川嶋啓揮, 大野栄三郎, 中村陽介, 中村正直, 宮原良二, 大宮直木, 後藤秀実

    日本超音波医学会 第85回学術集会  2012.5.25 

  19. WS6-8 小腸狭窄が疑われた患者に対するPillCam Patency Capsuleの使用経験

    中村正直, 大宮直木, 廣岡芳樹, 山村健史, 水谷太郎, 石原誠, 山田弘志, 名倉明日香, 宮原良二, 安藤貴文, 渡辺修, 後藤秀実

    第9回日本消化管学会総会  2013.1.26 

  20. WS10-7 クローン病小腸狭窄に対するバルーン拡張術の予後と手術回避に関わる因子

    山田弘志, 大宮直木, 中村正直, 後藤秀実

    第10回日本消化管学会総会学術集会  2014.2.15 

  21. W7-4 クローン病小腸狭窄に対するバルーン拡張術の予後とその合併症

    山田弘志, 中村正直, 後藤秀実

    第100回日本消化器病学会総会  2014.4.24 

     More details

    Presentation type:Symposium, workshop panel (public)  

  22. W09-05 小腸内視鏡を用いた小腸濾胞性リンパ腫診断の現状とStage I症例のリツキシマブ単剤治療成績

    中村正直, 山村健史, 後藤秀実

    第87回日本消化器内視鏡学会総会  2014.5.16 

     More details

    Presentation type:Symposium, workshop panel (public)  

  23. W13-02 バブルバルーン内視鏡(DBE)を用いたクローン病の小腸狭窄に対するバルーン拡張術と小腸病変の評価の有用性

    吉村透, 中村正直, 後藤秀実

    第87回日本消化器内視鏡学会総会  2014.5.17 

     More details

    Presentation type:Symposium, workshop panel (public)  

  24. 消W23-11 クローン病小腸病変の診断治療におけるカプセル内視鏡とダブルバルーン内視鏡の役割

    中村正直, 山村健史, 後藤秀実

    JDDW2014  2014.10.26 

     More details

    Presentation type:Symposium, workshop panel (public)  

  25. WS2-2 カプセル内視鏡はクローン病小腸粘膜病変の早期発見に有効である

    吉村透, 中村正直, 山村健史, 森瀬和宏, 名倉明日香, 松下正伸, 中野有泰, 大島啓嗣, 佐藤淳一, 水谷泰之, 上野泰明, 斎藤雅之, 松浦倫三郎, 渡辺修, 廣岡芳樹, 安藤貴文, 後藤秀実

    第11回日本消化管学会総会学術集会  2015.2.13 

     More details

    Presentation type:Symposium, workshop panel (public)  

  26. ワークショップ4 小腸疾患における小腸粘膜内栄養関連生物学的マーカーmRNA発現の検討

    中村正直, 渡辺修, 後藤秀実

    第101回日本消化器病学会総会  2015.5.15 

  27. [W07-09] 非特異性多発性小腸潰瘍症のマネージメントにおける小腸内視鏡の役割

    上野泰明, 中村正直, 後藤秀実

    第89回日本消化器内視鏡学会総会  2015.5.28 

     More details

    Presentation type:Symposium, workshop panel (public)  

  28. [W10-04] 小腸腫瘍に対するダブルバルーン内視鏡下EUSの診断能に関する検討

    水谷泰之, 中村正直, 後藤秀実

    第89回日本消化器内視鏡学会総会  2015.5.28 

     More details

    Presentation type:Symposium, workshop panel (public)  

  29. [W11-12] クローン病患者における臨床的寛解から粘膜治癒を目指す上でのカプセル内視鏡の有用性

    吉村透, 中村正直, 後藤秀実

    第89回日本消化器内視鏡学会総会  2015.5.28 

     More details

    Presentation type:Symposium, workshop panel (public)  

  30. [内W19-1] パテンシーカプセル不通過の新たな解釈

    澤田つな騎, 中村正直, 後藤秀実

    JDDW2015  2015.10.20 

     More details

    Presentation type:Symposium, workshop panel (public)  

  31. [WS3-10] 内視鏡的切除を試みた小腸粘膜下腫瘍の検討

    中村正直, 渡辺修, 山村健史, (名倉明日香), 松下正伸, (吉村透), 中野有泰, 大島啓嗣, 佐藤淳一, (上野泰明), 齋藤雅史, 松浦倫三郎, 澤田つな騎, 舩坂好平, 大野栄三郎, 宮原良二, 川嶋啓揮, 廣岡芳樹, 後藤秀実

    第12回日本消化管学会総会学術集会  2016.3.2 

     More details

    Presentation type:Symposium, workshop panel (public)  

  32. [WS9-9] 大腸カプセル内視鏡における全大腸観察を達成するために重要な臨床因子の検討

    佐藤淳一, 廣岡芳樹, 渡辺修, 中村正直, 山村健史, 後藤秀実

    第12回日本消化管学会総会学術集会  2016.3.2 

  33. [WS8-12] 虚血性小腸炎の特徴的な内視鏡所見についての検討

    佐藤淳一, 中村正直, 後藤秀実

    第102回日本消化器病学会総会  2016.4.27 

     More details

    Presentation type:Symposium, workshop panel (public)  

  34. [W05-7]大腸カプセル内視鏡検査における小ポリープの診断についての検討

    佐藤淳一, 中村正直, 後藤秀実

    第91回日本消化器内視鏡学会総会  2016.5.9 

     More details

    Presentation type:Symposium, workshop panel (public)  

  35. 原因不明消化管出血 (OGIB) における小腸カプセル内視鏡 (CE) 陰性例の長期予後とダブルバルーン内視鏡 (DBE) の有効性 : 予測スコアを用いた診断戦略

    内田元太, 中村正直, 後藤秀実

    第104回日本消化器病学会総会  2018.4.25 

     More details

    Presentation type:Symposium, workshop panel (public)  

  36. ワークショップ4:カプセル内視鏡診療の現況と将来大腸カプセル内視鏡における大腸ポリープ形態別診断精度の検討

    山田啓策, 中村正直, 後藤秀実

    第95回日本消化器内視鏡学会総会  2018.5.15 

     More details

    Presentation type:Symposium, workshop panel (public)  

  37. The study on the diagnostic accuracy of JNET classification for colorectal polyps

    Yamamura T, Nakamura M, Hirooka Y.

    2018.11.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

  38. 腸リンパ管拡張症の臨床的特徴と治療の工夫

    中村正直, 山村健史, 廣岡芳樹

    第105回日本消化器病学会総会  2019.5.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

  39. クローン病における粘膜治癒を予測する腸内細菌叢の探索

    服部峻, 中村正直, 廣岡芳樹

    第105回日本消化器病学会総会  2019.5.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

  40. 大腸カプセル内視鏡によるクローン病消化管病変の診断精度の検討

    山田啓策, 中村正直, 藤城光弘

    JDDW2019   2019.11.22 

     More details

    Presentation type:Symposium, workshop panel (public)  

  41. 当院におけるEUS-Elastographyを用いた大腸腫瘍深達度診断の検討

    江崎正哉,中村正直,山村健史,藤城光弘

    第16回日本消化管学会総会学術集会  2020.2.8 

     More details

    Presentation type:Symposium, workshop panel (public)  

  42. クローン病における小腸大腸粘膜関連細菌叢の検討

    服部峻, 中村正直, 藤城光弘

    第106回日本消化器病学会総会  2020.8.14 

     More details

    Presentation type:Symposium, workshop panel (public)  

  43. 消化管内視鏡治療における抗血栓薬の取り扱い「十二指腸ESD における抗血栓薬内服の影響」

    河村達哉, 廣瀨崇, 角嶋直美, 古川和宏, 石川恵里, 澤田つな騎, 前田啓子, 山村健史, 中村正直, 川嶋啓揮, 藤城光弘

    第17回日本消化管学会総会学術集会  2021.2.22 

     More details

    Presentation type:Symposium, workshop panel (public)  

  44. 高齢者潰瘍性大腸炎治療指針の検証「当院における高齢発症潰瘍性大腸炎の臨床的特徴」

    澤田つな騎, 中村正直, 山村健史, 前田啓子, 水谷泰之, 石川恵里, 藤城光弘

    第17回日本消化管学会総会学術集会  2021.2.22 

     More details

    Presentation type:Symposium, workshop panel (public)  

  45. 当院における免疫チェックポイント阻害剤による消化管免疫関連有害事象の有無での全生存期間についての検討

    山田健太朗,澤田つな騎,中村正直,山村健史,前田啓子,水谷泰之,石川恵里,藤城光弘

    第17回日本消化管学会総会学術集会  2021.2.22 

     More details

    Presentation type:Symposium, workshop panel (public)  

  46. ワークショップ:IBD診療におけるカプセル内視鏡「クローン病の予後予測因子とカプセル内視鏡Lewis scoreの臨床的意義の検討」

    梶川豪, 中村正直, 山村健史, 前田啓子, 澤田つ騎, 水谷泰之, 石川恵里, 橋口裕樹, 村手健太郎, 喜田裕一, 濵崎元伸, 江﨑正哉, 山田健太朗, 長谷川一成, 鳥山和浩, 池上脩二, 藤城光弘

    第14回日本カプセル内視鏡学会学術集会  2021.2.22 

     More details

    Presentation type:Symposium, workshop panel (public)  

  47. 大腸cT1b癌に対するESDの成績とPAE M(peranalendoscopicmyectomy)の可能性

    山村健史, 中村正直, 前田啓子

    101回日本消化器内視鏡学会総会  2021.5.14 

     More details

    Presentation type:Symposium, workshop panel (public)  

  48. 進化し続ける小腸内視鏡モダリティ

    中村正直

    第101回日本消化器病学会総会 シンポジウム8       2016.4.22 

     More details

    Presentation type:Oral presentation (invited, special)  

  49. 小腸内視鏡を用いた小腸疾患診療・アルゴニズム

    中村正直

    第21回 日本消化器内視鏡学会東海セミナ―  2011.1.22 

     More details

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  50. 内視鏡のUpdate ―小腸内視鏡、大腸用カプセル内視鏡―

    中村正直

    日本消化器病学会 東海支部第32回教育講演会  2014.12.6 

     More details

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  51. 大腸カプセル内視鏡の活用法と問題点

    中村正直

    第26回日本消化器内視鏡学会東海セミナー  2016.1.17 

     More details

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  52. 小腸内視鏡を活用した小腸疾患マネージメント

    中村正直

    第27回日本消化器内視鏡学会東海セミナー  2017.1.15 

     More details

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  53. 当院での潰瘍性大腸炎における生物学的製剤の治療

    澤田つな騎, 中村正直, 山村健史, 前田啓子, 水谷泰之, 石川恵里, 西川貴広, 服部峻, 山田啓策, 久野剛史, 梶川豪, 橋口裕樹, 江崎正哉, 喜田裕一, 濱崎元伸, 村手健太郎, 藤城光弘

    第16回 日本消化管学会総会学術集会  2020.2.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

  54. 小腸カプセル内視鏡(VCE)の原因不明消化管出血以外への適応拡大およびFICE診断の有用性

    大宮直木, 中村正直, 後藤秀実

    第81回日本消化器内視鏡学会総会  2011.8.17 

     More details

    Presentation type:Symposium, workshop panel (public)  

  55. 小腸カプセル内視鏡(VCE)の適応拡大に向けて:Agile-Jpatency capsule(AJP) の有用性と安全性

    大宮直木, 中村正直, 後藤秀美

    第82回日本消化器内視鏡学会総会  2011.10.22 

     More details

    Presentation type:Symposium, workshop panel (public)  

  56. ダブルバルーン小腸内視鏡(DBE)の偶発性とその対策

    大宮直木, 中村正直, 後藤秀美

    第83回日本消化器内視鏡学会総会  2012.5.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

  57. 当院におけるPillCam®パテンシーカプセル検査の現状と今後の課題

    中村正直, 大宮直木, 山村健史, 水谷太郎, 石原誠, 山田弘志, 名倉明日香, 吉村透, 宮原良二, 舩坂好平, 廣岡芳樹, 伊藤彰浩, 川嶋啓揮, 大野栄三郎, 安藤貴文, 渡辺修, 後藤秀実

    第6回日本カプセル内視鏡学会学術集会  2013.7.28 

     More details

    Presentation type:Symposium, workshop panel (public)  

  58. クローン病に対するPillCam Patency Capsule(PPC)の開通性評価とカプセル内視鏡の有用性についての検討

    吉村透, 大宮直木, 中村正直, 水谷太郎, 山村健史, 石原誠, 山田弘志, 名倉明日香, 舩坂好平, 大野栄三郎, 宮原良二, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 安藤貴文, 渡辺修, 後藤秀実

    第6回日本カプセル内視鏡学会学術集会  2013.7.28 

     More details

    Presentation type:Symposium, workshop panel (public)  

  59. NSAIDs起因性小腸傷害および膜様狭窄の発生リスクと予防・治療、予後

    大宮直木, 中村正直, 後藤秀美

    第86回日本消化器内視鏡学会総会  2013.10.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

  60. Diagnosis and Therapeutic Assessment of Early-Stage Follicular Lymphoma with Small-bowel Involvement Using Videocapsule Endoscopy and Double-Balloon Endoscopy

    Nakamura M, Ohmiya N, Goto H.

    JDDW2013  2013.10.2 

  61. クローン病術後症例に対するパテンシーカプセルの適応

    吉村透, 中村正直, 山村健史, 山田弘志, 名倉明日香, 中野有泰, 舩坂好平, 大野栄三郎, 宮原良二, 川嶋啓揮, 伊藤彰浩, 廣岡芳樹, 安藤貴文, 渡辺修, 後藤秀実

    第7回日本カプセル内視鏡学会学術集会  2014.7.27 

     More details

    Presentation type:Symposium, workshop panel (public)  

  62. カプセル内視鏡読影センターにおける読影支援技師の役割

    (本田亘), 中村正直, 後藤秀実

    第7回日本カプセル内視鏡学会学術集会  2014.7.27 

     More details

    Presentation type:Symposium, workshop panel (public)  

  63. Blue LASER Imaging(BLI)拡大診断とpit pattern診断の大腸腫瘍に対する診断能の比較検討

    中野有泰, 中村正直, 後藤秀実

    JDDW2014  2014.10.2 

  64. Usefulness of Evaluating Small-intestinal Mucosa in Mild Crohn's Disease (CD) Using Capsule Endoscopy (CE)

    Yoshimura T, Nakamura M, Goto H.

    JDDW2014  2014.10.2 

     More details

    Presentation type:Symposium, workshop panel (public)  

  65. 当院における大腸カプセル内視鏡の使用経験について

    佐藤淳一, 中村正直, 渡辺修, 山村健史, (森瀬和宏), 名倉明日香, 前田啓子, 松下正伸, 吉村透, 中野有泰, 大島啓嗣, 廣岡芳樹, 安藤貴文, 後藤秀実

    第8回日本カプセル内視鏡学会学術集会  2015.2.15 

     More details

    Presentation type:Symposium, workshop panel (public)  

  66. [S01-05] 当院における小腸結核の内視鏡像の検討

    齋藤雅之, 中村正直, 後藤秀実

    第89回日本消化器内視鏡学会総会  2015.5.28 

  67. [S02-12] PPI内服と小腸粘膜障害の関係 ―カプセル内視鏡を用いた検討―

    松浦倫三郎, 中村正直, 後藤秀実

    第89回日本消化器内視鏡学会総会  2015.5.28 

     More details

    Presentation type:Symposium, workshop panel (public)  

  68. [CS4-7] クローン病の小腸病変の内視鏡評価におけるmodality選択の検討

    澤田つな騎, 廣岡芳樹, 渡辺修, 中村正直, 山村健史, 後藤秀実

    第12回日本消化管学会総会学術集会  2016.3.2 

     More details

    Presentation type:Symposium, workshop panel (public)  

  69. [S8‒4]小腸腫瘍様病変に対するダブルバルーン内視鏡診断の検討

    山村健史, 中村正直, 後藤秀実

    第102回日本消化器病学会総会  2016.4.27 

     More details

    Presentation type:Symposium, workshop panel (public)  

  70. [S1‒9]ダブルバルーン小腸内視鏡検査によりinfliximab治療を決定した小腸切除後のクローン病患者の長期経過

    渡辺修, 中村正直, 後藤秀実

    第102回日本消化器病学会総会  2016.4.27 

     More details

    Presentation type:Symposium, workshop panel (public)  

  71. シンポジウム Fusion機能によるRFAの治療支援〜RFA、TACE後の追加焼灼における有用性

    石津洋二, 葛谷貞二, 大野栄三郎, 中村正直, 本多隆, 川嶋啓揮, 廣岡芳樹, 後藤秀実

    Ultrasonic Week 2016  2016.5.29 

     More details

    Presentation type:Symposium, workshop panel (public)  

  72. 消化器3 通常型膵菅癌における造影CTと造影EUSの血行動態の相違点について"

    須原寛樹, 廣岡芳樹, 川嶋啓揮, 大野栄三郎, 林大樹朗, 石津洋二, 葛谷貞二, 本多隆, 中村正直, 後藤秀実

    Ultrasonic Week 2016  2016.5.29 

     More details

    Presentation type:Symposium, workshop panel (public)  

  73. Prospective study of capsule endoscopy for evaluating the therapeutic effects in patients with Crohn’s disease

    Nakamura M,Yamamura T, Hirooka Y.

    JDDW2018 KOBE  2018.11.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

  74. ダブルバルーン内視鏡にて診断を行った小腸粘膜下腫瘍(SMT)の検討と小さなSMTに対する内視鏡的切除の試み

    中村正直, 山村健史, 廣岡芳樹

    JDDW2018 KOBE  2018.11.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

  75. 大腸カプセル内視鏡を用いたクローン病全消化管観察の試み

    山田啓策, 中村正直, 山村健史, 前田啓子, 澤田つな騎, 水谷泰之, 丹羽慶樹, 石川恵里, 大塚裕之, 鈴木悠土, 西川貴広, 石田哲也, 久野剛史, 服部崚,梶川豪, 橋口裕樹, 村手健太郎, 喜田裕一, 濵崎元伸, 江﨑正哉, 廣岡芳樹

    第12回日本カプセル内視鏡学会学術集会  2019.2.4 

  76. PARD6Bによる腸管上皮細胞の新たな防御機構の同定

    前田啓子, 中村正直, 廣岡芳樹

    第105回日本消化器病学会総会  2019.5.11 

     More details

    Presentation type:Symposium, workshop panel (public)  

  77. 潰瘍性大腸炎において免疫調整剤を中止する際の粘膜治癒の意義

    澤田つな騎, 中村正直, 廣岡芳樹

    第97回日本消化器内視鏡学会総会  2019.6.3 

     More details

    Presentation type:Symposium, workshop panel (public)  

  78. 腸リンパ管拡張症の診断と治療

    中村正直, 山村健史, 前田啓子, 澤田つな騎, 水谷泰之, 藤城光弘

    第57回日本小腸学会学術集会  2019.1.19 

     More details

    Presentation type:Symposium, workshop panel (public)  

  79. Objective evaluation of the therapeutic effect of Ustekinumab in patients with Crohn disease

    Murate K,Nakamura M,Fujishiro M.

    JDDW2019 KOBE  2019.11.21 

     More details

    Presentation type:Symposium, workshop panel (public)  

  80. 単発性小腸Peutz-Jeghers型ポリープに関する臨床的検討

    鳥山和浩, 中村正直, 山村健史, 前田啓子, 澤田つな騎, 水谷泰之, 石川恵里, 梶川豪, 村手健太郎, 喜田裕一, 江﨑正哉, 濱崎元伸, 角嶋直美, 古川和宏, 藤城光弘

    第58回日本小腸学会学術集会  2020.10.24 

     More details

    Presentation type:Symposium, workshop panel (public)  

  81. 小腸疾患の診断と治療の最前線「虚血性小腸炎の臨床的特徴についての検討」

    中村正直, 山村健史, 前田啓子, 澤田つな騎, 水谷泰之, 石川恵里, 角嶋直美, 古川和宏, 藤城光弘

    第17回日本消化管学会総会学術集会  2021.2.22 

  82. 大腸カプセル内視鏡を用いたクローン病全消化管観察の試み

    中村正直, 山村健史, 藤城光弘

    第101回日本消化器内視鏡学会総会  2021.5.14 

     More details

    Presentation type:Symposium, workshop panel (public)  

  83. カプセル内視鏡による大腸癌検診の試み

    中村正直, 丹羽康正, 後藤秀実

    (DDW-Japan2005)第43回日本消化器集団検診学会大会  2005.10.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

  84. カプセル内視鏡を用いた大腸がん検診の試み―問題と対策―

    中村正直, 丹羽康正, 後藤秀実

    第48回日本消化器病学会大会(DDW-Japan2006)  2006.10.14 

     More details

    Presentation type:Symposium, workshop panel (public)  

  85. PD3-7 NSAID起因性小腸障害に対するレバミピドの予防効果

    中村正直, 丹羽康正, 後藤秀実

    第73回日本消化器内視鏡学会総会  2007.5.9 

     More details

    Presentation type:Symposium, workshop panel (public)  

  86. PD13-8 過敏性腸症候群に対するカプセル内視鏡を用いた客観的診断の試み ―大腸蠕動運動頻度・様式の定量化―

    中村正直, 丹羽康正, 藤本英雄

    第73回日本消化器内視鏡学会総会  2007.5.11 

     More details

    Presentation type:Symposium, workshop panel (public)  

  87. 内PD2-5 ダブルバルーン内視鏡(DBE)の現状、放射線被曝と今後の展開

    大宮直木, 中村正直, 後藤秀実

    JDDW2009  2009.10.14 

     More details

    Presentation type:Symposium, workshop panel (public)  

  88. PD8-1 ダブルバルーン内視鏡(DBE)を用いた小腸疾患の診断と治療

    大宮直木, 中村正直, 後藤秀実

    第96回日本消化器病学会総会  2010.4.23 

     More details

    Presentation type:Symposium, workshop panel (public)  

  89. 内PD9-14 原因不明消化管出血(OGIB)の診断におけるカプセル内視鏡、ダブルバルーン内視鏡の有用性

    大宮直木, 中村正直, 後藤秀実

    JDDW2012  2012.10.11 

     More details

    Presentation type:Symposium, workshop panel (public)  

  90. 消PD18-10 ダブルバルーン内視鏡深部挿入困難に関わる因子の検討

    中村正直, 後藤秀実, C.Fraser

    JDDW2012  2012.10.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

  91. PD6-11 蛋白漏出性腸症を来す腸リンパ管拡張症の病態分類の有用性

    大宮直木, 中村正直, 後藤秀実

    第99回日本消化器病学会総会  2013.3.23 

     More details

    Presentation type:Symposium, workshop panel (public)  

  92. PD5-8 PillCam®パテンシーカプセルの開通性に関わる因子の検討

    中村正直, 大宮直木, 後藤秀実

    第85回日本消化器内視鏡学会総会  2013.5.11 

     More details

    Presentation type:Symposium, workshop panel (public)  

  93. PD7-5 PillCam®パテンシーカプセルによる消化管開通性評価に影響する因子の検討

    山村健史, 中村正直, 後藤秀実

    第100回日本消化器病学会総会  2014.4.23 

     More details

    Presentation type:Symposium, workshop panel (public)  

  94. パネルディスカッション 消化器3 ポジションセンサーとCT-fusion画像を使用した体外式超音波検査の膵尾部描出能の検討

    鷲見肇, 廣岡芳樹, 川嶋啓揮, 大野栄三郎, 石津洋二, 葛谷貞二, 本多隆, 中村正直, 春田純一, 後藤秀実

    Ultrasonic Week 2016  2016.5.29 

     More details

    Presentation type:Symposium, workshop panel (public)  

  95. 狭窄を有するクローン病患者のダブルバルーン内視鏡を用いた小腸病変モニタリングの意義

    澤田つな騎, 中村正直, 後藤秀実

    JDDW2016  2016.11.4 

     More details

    Presentation type:Symposium, workshop panel (public)  

  96. パネルディスカッションPD03-3原因不明消化管出血(0GIB)の長期予後とマネージメント

    内田元太, 中村正直, 後藤秀実

    第93回日本消化器内視鏡学会  2017.7.13 

     More details

    Presentation type:Symposium, workshop panel (public)  

  97. パネルディスカッション4 小腸狭窄を有する臨床的寛解のクローン病患者に対するダブルバルーン内視鏡の役割

    澤田つな騎, 中村正直, 後藤秀実

    第95回日本消化器内視鏡学会総会  2018.5.16 

     More details

    Presentation type:Symposium, workshop panel (public)  

  98. 脂肪由来間葉系幹細胞濾液(FSCL)の成分および急性腸炎モデルマウスに対する有効性の検討

    西川貴広, 中村正直, 廣岡芳樹

    第105回日本消化器病学会総会  2019.5.9 

     More details

    Presentation type:Symposium, workshop panel (public)  

  99. 当院におけるUstekinumabの治療成績の検討

    村手健太郎, 中村正直, 廣岡芳樹

    第105回日本消化器病学会総会  2019.5.9 

  100. Cold polypectomyの遺残再発に関する前向き検討とそこから分かる現状

    山村健史, 中村正直, 廣岡芳樹

    第97回日本消化器内視鏡学会総会  2019.6.1 

     More details

    Presentation type:Symposium, workshop panel (public)  

  101. Endoscopic intervention for submucosal tumor in the small bowel at double-balloon endoscopy

    Nakamura M, Yamamura T, Hirooka Y.

    第97回日本消化器内視鏡学会総会  2019.6.3 

     More details

    Presentation type:Symposium, workshop panel (public)  

  102. 大腸カプセル内視鏡を用いたクローン病全消化管観察の有用性について

    山田啓策, 中村正直, 廣岡芳樹

    第97回日本消化器内視鏡学会総会  2019.6.3 

     More details

    Presentation type:Symposium, workshop panel (public)  

  103. ダブルバルーン内視鏡(DBE)を用いた小腸疾患の診断と治療の有効性

    大宮直木, 中村正直, 後藤秀実

    第81回日本消化器内視鏡学会総会  2011.8.17 

     More details

    Presentation type:Symposium, workshop panel (public)  

  104. 小腸疾患における各種検査法の有用性

    大宮直木, 中村正直, 後藤秀実

    第75回日本消化器内視鏡学会総会  2008.5.26 

     More details

    Presentation type:Symposium, workshop panel (public)  

  105. 小腸出血の診断における各種検査の有用性

    大宮直木, 中村正直, 後藤秀実

    JDDW2008  2008.10.2 

     More details

    Presentation type:Symposium, workshop panel (public)  

  106. 小腸の小病変に対するダブルバルーン内視鏡(DBE)、カプセル内視鏡(VCE)、小腸X線検査の診断能の比較

    大宮直木, 中村正直, 後藤秀実

    第77回日本消化器内視鏡学会総会  2009.5.21 

     More details

    Presentation type:Symposium, workshop panel (public)  

  107. カプセル内視鏡による小腸腫瘍診断

    中村正直, 大宮直木, 後藤秀実

    第79回日本消化器内視鏡学会総会  2010.2.13 

     More details

    Presentation type:Symposium, workshop panel (public)  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 4

  1. Clinical research of Crohn's disease using new small-bowel endoscopy

    2011.4 - 2012.3

      More details

    Grant type:Competitive

  2. 小腸濾胞性リンパ腫診断

    2010.10 - 2011.3

    北村記念血液疾患研究基金 

      More details

    Grant type:Competitive

    小腸濾胞性リンパ腫に対する内視鏡診断の有用性を検討する。

  3. カプセル内視鏡を用いた大腸の運動機能解析  ―過敏性腸症候群の客観的評価と他大腸疾患への応用―

    2007.4 - 2008.10

      More details

    Grant type:Competitive

    堀情報科学振興財団助成

  4. カプセル内視鏡を用いた大腸の運動機能解析―過敏性腸症候群の客観的評価と他大腸疾患への応用―

    2006.4 - 2007.3

    堀情報科学振興財団助成金 

      More details

    Authorship:Principal investigator  Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. カプセル内視鏡を用いた過敏性腸症候群の客観的評価

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

      More details

    Authorship:Principal investigator 

  2. Evaluation of biomarkers related to intestinal epithelial disorder using endoscopic biopsy specimen

    Grant number:16K09406  2016.4 - 2020.3

    Nakamura Masanao

      More details

    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Intestinal biopsy specimen in endoscopy revealed the distribution of mRNA expression of biological marker in human small intestinal mucosa, and showed that nutrient absorption structure could be maintained in intestinal mucosa of patients with small bowel disease. Factors related to intestinal epithelial damage in acute enteritis model mice were examined, and we considered the potential of regenerative medicine in the treatment. Focusing on some components of stem cells, we showed their anti-inflammatory and healing effects for acute colitis. Considering the relationship between the intestinal epithelium and the mucosa-associated bacterial flora, the sample of intestinal mucosa was collected with a brush forceps during endoscopy and we showed a strong relationship between the mucosa-associated bacterial flora and colitis.

  3. 炎症性腸疾患における新規粘膜関連細菌叢検出法を用いた腸粘膜炎症プロファイルの作成

    Grant number:20K07801  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    中村 正直, 本多 隆, 山村 健史, 川嶋 啓揮, 藤城 光弘

      More details

    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    炎症性腸疾患の腸表面の粘膜関連細菌叢から粘膜固有層までの免疫増幅経路は同時に同部位で評価すべき事象である。同じ部位の内視鏡生検検体を用いて、A)粘膜関連細菌叢の最適検出法を見出したうえで採取、細菌16SrRNA次世代シークエンス解析を行う。B)生検組織のフローサイトメトリーによる免疫担当細胞とT細胞の分布解析、細胞内炎症性サイトカインの定量を行い、免疫応答をカテゴリー化する。C)粘膜内蛋白質量解析により、炎症反応のKeyとなる分子の量と種類につき網羅的に解析する。A)B)C)から得た結果を疾患活動性とリンクさせ、腸粘膜炎症プロファイルを作成する。
    研究内容について、潰瘍性大腸炎患者の直腸腸粘液について、腸管前処置有りと無しの2群で採取を試みた。共に腸粘液の採取が可能であった。前処置を行っていても粘液量は解析課可能量が確保された。
    内視鏡下にネットまたはブラシによる腸表面擦過と研究用生検を行い、ネットとブラシによる粘膜関連細菌叢採取量と菌種の頻度につき比較を行った。採取中に嫌気性菌量を保持できるよう、内視鏡は二酸化炭素送気で行い、内視鏡から検体を取り出す際にも酸素に触れにくいチューブを使用した。採取された粘液についてたんぱく質の質量分析と16SrRNA次世代シークエンスによる細菌叢解析を行った。質量分析においては目標のタンパク質であるS-100, ムチンなど多種類の要素を認め、組織の炎症の程度と相関傾向を検討することができた。細菌叢解析では個体差はあるが粘液関連細菌叢の評価が可能であることが確認できた。続けて10例において回腸末端、盲腸、直腸の同部位において腸粘液、生検組織の採取ができた。
    本成果の意義は、粘液の質量分析を行うことで、腸粘膜炎症プロファイルの作成において追加情報を得てさらに詳細なネットワークを証明できる可能性がみえたことである。1点の部位について腸表面の管腔側と生体側を同時に検体を採取したうえでの解析を連続して行い、更には腸粘液の内容の変化や含有因子を調べることは、潰瘍性大腸炎の発症に関する物質を見いだす手がかりになる点が重要と考えた。
    2020年度に計画していた内視鏡による大腸粘膜と生検組織採取が同部位で可能であることが確認できた。
    最適な腸粘液採取方法を検討することを継続し、回腸末端、盲腸、直腸で最終した検体(粘液と生検組織)について評価方法を検討する。腸粘液については内部に含まれる質量分析を進め、生検組織の内容との相関を検討する。同検体について細菌叢解析、メタボローム解析を試みる。

  4. 胆膵疾患の十二指腸主乳頭擦過採取による表在細菌叢プロファイル作成と臨床応用の探索

    Grant number:21K19897  2021.7 - 2024.3

    科学研究費助成事業  挑戦的研究(萌芽)

    川嶋 啓揮, 大野 栄三郎, 石川 卓哉, 飯田 忠, 中村 正直

      More details

    Authorship:Coinvestigator(s) 

    本研究の目的は、胆膵疾患の十二指腸主乳頭(PV)のブラシ擦過採取による表層細菌叢プロファイル作成と将来の基礎研究・臨床応用の可能性を探索することである。Fusobacterium nucleatumと大腸癌の関連が報告され、膵癌についても腫瘍内細菌の存在が明らかとなり注目されている。しかし、膵癌以外の胆膵疾患に関する報告は乏しい。PVは胆管・膵管が開口し、病変を通過した胆汁・膵液にさらされており、直視下に低侵襲でサンプル採取出来る特徴をもつ。本研究はPV擦過採取による細菌叢解析を行い今後の胆膵疾患の表層細菌叢、手術検体による病変内細菌叢、PV表層細菌叢と臨床所見を比較検討できるかを探索する。

  5. Enteric Bacteria Collect Magnetically Driven Capsule Robot for Intestinal Flora Analysis

    Grant number:19K04316  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Coinvestigator(s) 

  6. 超音波内視鏡下エラストグラフィによる組織硬度測定による膵癌の臨床病理学的病態解析

    Grant number:18K12054  2018.4 - 2021.3

    大野 栄三郎

      More details

    Authorship:Coinvestigator(s) 

    膵癌は豊富な線維性間質(がん関連線維芽細胞:cancer-associated fibroblast:CAF)を有し、「硬い」腫瘍と認識され、一方で癌細胞は硬い組織環境下において更に悪性度を増すとの報告も認め、膵癌およびその周囲組織の硬度と膵癌細胞の悪性度及び進行度に密接に関連している可能性がある。膵癌組織においてCAFは単なるbystanderではなく膵癌の進展など病態に強く関わっていることも報告されている。我々は臨床的に膵癌の硬度を測定し(超音波内視鏡下エラストグラフィ及び組織に対する原子間力顕微鏡(AFM))、硬度と膵癌の病理像(癌促進性、癌抑制性CAFの比率、分布)と臨床像(予後、化学療法の奏功率)との関連性を明らかにすることを目的としている。
    1)EUS-SWE(EUS-guided shear wave elastography)による膵癌を含む膵病変組織硬度測定
    超音波エラストグラフィは非侵襲的に組織弾性を測定し画像化、数値化する技術である。本年はEUS-SWEの膵癌をはじめとする膵病変の組織硬度測定精度の検証を行うため、もう一つの超音波エラストグラフィシステムであるStrain elastography法と対比して、硬度測定を行い(学会報告、論文報告JMU2019)、膵癌組織硬度測定における超音波エラストグラフィの使用方法に関する最適な測定条件を見いだす。
    2)膵癌、膵腫瘍患者の進行度と治療効果と組織硬度との関連性の検討
    EUS-SWE、超音波エラストグラフィにて得られた組織硬度は膵癌や自己免疫性膵炎(ステロイド治療前)にて他膵腫瘤性病変や正常膵に比して高硬度を示した。切除病理標本の免疫組織染色(AZAN,αSMA, CD31)による検討では、高硬度を示す膵癌においては膵癌組織中の線維芽細胞の比率が高い傾向を認めた。(未発表)
    EUS-SWを用いた膵癌、膵腫瘍測定における精度評価、問題点を抽出し、学会報告を行った。また現在論文投稿中である。硬度測定においてはStrain elastography法をヒストグラム解析にて半定量化する結果を用いることで診断精度の向上を認めた。
    現在、実際の膵癌の組織硬度測定結果と病理組織の免疫組織学的検討との対比を行うと同時に、組織硬度に関連するタンパク、CAFの発現を病理組織FFPE標本を用い検討する準備を行っている。臨床面においては膵癌組織硬度の差異をEUS-FNAによる針生検の病理組織所見との対比を行う前向き研究、膵癌化学療法前後における組織硬度変化の前向き研究を現在on goingにて進行中である。
    1)膵癌切除症例の病理組織所見と術前画像所見の対比:膵癌切除病理標本の間質組織の組成、成分解析を行うための免疫染色を行う。昨年度施行した免疫染色に加え、ミオシン軽鎖染色、Yap染色を追加する予定。さらに、線維芽細胞の組織硬度に関連すると考えられるlysyl oxidase(Lox)発現量を免疫染色にて評価を行う。(継続課題)
    2)膵癌組織硬度と発現遺伝子異常の相関の検討:膵癌組織を間質のCAFの発現、硬度により分類し、硬度の異なる膵癌組織における遺伝子異常の発現プロファイルを探索するため、EUS-FNAにて採取された膵癌検体もしくは切除例の病理組織標本よりlaser microdissection法にて癌組織を切り出し、癌組織よりDNAを抽出し、膵癌に代表的に認められる遺伝子変異をマイクロアレイにて解析し、硬度の異なる膵癌の遺伝子プロファイルの差異を検討する。(継続課題)
    3)物理的な膵癌をはじめとした臓器、組織の硬度測定法の開発を目指す。
    臓器の組織組成、物理学的な生体組織の特性を評価し、既存の診断機器、治療機器、デバイスの機能的特性を新たな研究領域として体系化する。具体的には細胞硬度、細胞集塊硬度、組織硬度、臓器硬度にスケール分類した場合、各スケールに併せた適切な硬度測定方法を確立する。当面、臨床的に最優先の課題としては生検にて採取された細胞集塊の硬度測定の定量化と実際の疾患、病態、既存の硬度測定(エラストデータ)との相関を示すベースとなるデータの集積を行う。
    1)2)に関しては既存の膵癌組織を用いた遺伝子プロファイル、タンパク発現解析を目的としたゲノム解析研究専門審査委員会の承認を得て研究を開始している。

  7. Development of new diagnostic method for duodenal ampullary carcinoma amenable to local excision

    Grant number:18K08614  2018.4 - 2021.3

      More details

    Authorship:Coinvestigator(s) 

▼display all

 

Teaching Experience (On-campus) 3

  1. 臨床実習1

    2020

  2. 臨床実習2

    2020

  3. 臨床系講義

    2020

     詳細を見る

    下部消化管疾患について

 

Social Contribution 3

  1. 愛知県健康づくり推進協議会がん対策部会胃がん・大腸癌検診制度管理委員会委員長

    Role(s):Chief editor

    2019.11

  2. 愛知県消化器集検調査研究会  委員

    Role(s):Investigater

    2019.11

  3. 厚生労働省DPCワーキンググループ 

    Role(s):Investigater

    2019.2