Updated on 2022/05/12
博士（医学） （ 2002.3 名古屋大学 ）
Natural history of transthyretinVal30Met familial amyloid polyneuropathy: analysis of late-onset cases from non-endemic areas Reviewed
Koike H, Tanaka F, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Fujitake J, Kawanami T, Kato T, Yamamoto M, Sobue G.
J Neurol Neurosurg Psychiatry Vol. 83 page： 152-158 2012.2
Clinicopathological features of acute autonomic and sensory neuropathy Reviewed
Koike H, Atsuta N, Adachi H, Iijima M, Katsuno M, Yasuda T, Fukada Y, Yasui K, Nakashima K, Horiuchi M, Shiomi K, Fukui K, Takashima S, Morita Y, Kuniyoshi K, Hasegawa Y, Toribe Y, Kajiura M, Takeshita S, Mukai E, Sobue G.
Brain Vol. 133 page： 2881-2896 2010
Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation.
Koike H, Kiuchi T, Iijima M, Ueda M, Ando Y, Morozumi S, Tomita M, Kawagashira Y, Watanabe H, Katsuno M, Shimoyama Y, Okazaki Y, Kamei H, Sobue G.
J Neurol Neurosurg Psychiatry Vol. 82 page： 1287-1290 2011
Expanding the concept of inflammatory neuropathies Invited
Koike H, Sobue G.
Brain Vol. 133 page： 2848-2851 2010
Diagnosis of sporadic transthyretin Val30Met familial amyloid polyneuropathy: a practical analysis.
Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Tanaka F, Sobue G.
Vol. 18 page： 53-62 2011
Slowly progressive autonomic neuropathy with antiganglionic acetylcholine receptor antibody Reviewed
Koike H, Koyano S, Morozumi S, Kawagashira Y, Iijima M, Katsuno M, Hattori N, Vernino S, Sobue G.
J Neurol Neurosurg Psychiatry Vol. 81 page： 586-587 2010
Paraneoplastic neuropathy: wide-ranging clinicopathological manifestations.
Koike H, Tanaka F, Sobue G.
Curr Opin Neurol Vol. 24 page： 504-510 2011
Diagnosis of familial amyloid polyneuropathy: wide-ranged clinicopaathological features Invited Reviewed
Koike H, Sobue G.
Expert Opin Med Diagn Vol. 4 page： 323-331 2010
The wide range of clinical manifestations in leprous neuropathy: two case reports.
Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Nagamatsu M, Sobue G.
Intern Med Vol. 50 page： 2223-2226 2011
Morphological progression of myelin abnormalities in IgM-monoclonal gammopathy of undetermined significance anti-myelin-associated glycoprotein neuropathy Reviewed
Kawagashira Y, Koike H, Tomita M, Morozumi S, Iijima M, Nakamura T, Katsuno M, Tanaka F, Sobue G.
J Neuropathol Exp Neurol Vol. 69 page： 1143-1157 2010
IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive muscle atrophy Reviewed
Kawagashira Y, Kondo N, Atsuta N, Iijima M, Koike H, Katsuno M, Tanaka F, Kusunoki S, Sobue G.
Muscle Nerve Vol. 42 page： 433-435 2010
Differential response to intravenous immunoglobulin (IVIg) therapy among multifocal and polyneuropathy types of painful diabetic neuropathy Reviewed
Vol. 17 page： 1003-1008 2010
Pyramidal tract involvement in Guillain-Barré syndrome associated with anti-GM1 antibody Reviewed
Tomita M, Watanabe H, Morozumi S, Kawagashira Y, Iijima M, Nakamura T, Katsuno M, Koike H, Hattori N, Hirayama M, Kusunoki S, Sobue G.
J Neurol Neurosurg Psychiatry Vol. 81 page： 583-585 2010
*Neuropathic pain correlates with myelinated fibre loss and cytokine profile in POEMS syndrome Reviewed
Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Watanabe H, Tanaka F, Doyu M, Sobue G
J Neurol Neurosurg Psychiatry Vol. 79 ( 10 ) page： 1171-1179 2008.10
*The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy Reviewed
Koike H, Morozumi S, Kawagashira Y, Iijima M, Yamamoto M, Hattori N, Tanaka F, Nakamura T, Hirayama M, Ando Y, Ikeda SI, Sobue G
Amyloid Vol. 15 page： 1-7 2009.7
*Distinct characteristics of amyloid deposits in early- and late-onset transthyretin Val30Met familial amyloid polyneuropathy Reviewed
Koike H, Ando Y, Ueda M, Kawagashira Y, Iijima M, Fujitake J, Hayashi M, Yamamoto M, Mukai E, Nakamura T, Katsuno M, Hattori N, Sobue
J Neurol Sci Vol. 287 ( 1-2 ) page： 178-184 2009.12
*Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP Reviewed
Iijima M, Tomita M, Morozumi S, Kawagashira Y, Nakamura T, Koike H, Katsuno M, Hattori N, Tanaka F, Yamamoto M, Sobue G
Neurology Vol. 73 ( 17 ) page： 1348-1352 2009.10
*Electrophysiological features of late-onset transthyretin Met30 familial amyloid polyneuropathy unrelated to endemic foci Reviewed
Koike H, Kawagashira Y, Iijima M, Yamamoto M, Hattori N, Tanaka F, Hirayama M, Ando Y, Ikeda S, Sobue G
J Neurol Vol. 255 ( 10 ) page： 1526-1533 2008.10
In vivo visualization of eosinophil secretion in eosinophilic granulomatosis with polyangiitis: An ultrastructural study.
Koike H, Nishi R, Furukawa S, Mouri N, Fukami Y, Iijima M, Katsuno M
Allergology international : official journal of the Japanese Society of Allergology 2022.4
Dosage effects of PMP22 on nonmyelinating Schwann cells in hereditary neuropathy with liability to pressure palsies.
Koike H, Furukawa S, Mouri N, Fukami Y, Iijima M, Katsuno M
Neuromuscular disorders : NMD 2022.4
ANCA-Associated Vasculitic Neuropathies: A Review
Koike Haruki, Nishi Ryoji, Ohyama Ken, Morozumi Saori, Kawagashira Yuichi, Furukawa Soma, Mouri Naohiro, Fukami Yuki, Iijima Masahiro, Sobue Gen, Katsuno Masahisa
NEUROLOGY AND THERAPY Vol. 11 ( 1 ) page： 21 - 38 2022.3
Severe and long-lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID-19: A case report.
Jozuka R, Kimura H, Uematsu T, Fujigaki H, Yamamoto Y, Kobayashi M, Kawabata K, Koike H, Inada T, Saito K, Katsuno M, Ozaki N
Neuropsychopharmacology reports Vol. 42 ( 1 ) page： 114 - 119 2022.3
Unique Phenotypes With Corresponding Pathology in Late-Onset Hereditary Transthyretin Amyloidosis of A97S vs. V30M
Hsueh Hsueh-Wen, Chao Chi-Chao, Chang Koping, Jeng Yung-Ming, Katsuno Masahisa, Koike Haruki, Hsieh Sung-Tsang
FRONTIERS IN AGING NEUROSCIENCE Vol. 13 page： 786322 2022.1
Emerging Infection, Vaccination, and Guillain-Barre Syndrome: A Review
Koike Haruki, Chiba Atsuro, Katsuno Masahisa
NEUROLOGY AND THERAPY Vol. 10 ( 2 ) page： 523 - 537 2021.12
Multidisciplinary Approaches for Transthyretin Amyloidosis
Koike Haruki, Okumura Takahiro, Murohara Toyoaki, Katsuno Masahisa
CARDIOLOGY AND THERAPY Vol. 10 ( 2 ) page： 289 - 311 2021.12
[Recommendations (Proposal) for promoting research for overcoming neurological diseases 2020].
Mochizuki H, Aoki M, Ikenaka K, Inoue H, Iwatsubo T, Ugawa Y, Okazawa H, Ono K, Onodera O, Kitagawa K, Saito Y, Shimohata T, Takahashi R, Toda T, Nakahara J, Matsumoto R, Mizusawa H, Mitsui J, Murayama S, Katsuno M, Future Vision Committee of Japanese Society of Neurology., Aoki Y, Ishiura H, Izumi Y, Koike H, Shimada H, Takahashi Y, Tokuda T, Nakajima H, Hatano T, Misawa S, Watanabe H
Rinsho shinkeigaku = Clinical neurology Vol. 61 ( 11 ) page： 709 - 721 2021.11
Association between neurosarcoidosis with autonomic dysfunction and anti-ganglionic acetylcholine receptor antibodies
Oishi Makoto, Mukaino Akihiro, Kunii Misako, Saito Asami, Arita Yukimasa, Koike Haruki, Higuchi Osamu, Maeda Yasuhiro, Abiru Norio, Yamaguchi Naohiro, Kawano Hiroaki, Tsuiki Eiko, Tanaka Tomonori, Matsuo Hidenori, Katsuno Masahisa, Tanaka Fumiaki, Tsujino Akira, Nakane Shunya
JOURNAL OF NEUROLOGY Vol. 268 ( 11 ) page： 4265 - 4279 2021.11
Paraproteinemia and neuropathy
Koike Haruki, Katsuno Masahisa
NEUROLOGICAL SCIENCES Vol. 42 ( 11 ) page： 4489 - 4501 2021.11
Nerve biopsy in acquired neuropathies
Sommer Claudia, Carroll Antonia S., Koike Haruki, Katsuno Masahisa, Ort Nora, Sobue Gen, Vucic Steve, Spies Judith M., Doppler Kathrin, Kiernan Matthew C.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 26 page： S21 - S41 2021.11
Ratio of urinary N-terminal titin fragment to urinary creatinine is a novel biomarker for amyotrophic lateral sclerosis
Yamada Shinichiro, Hashizume Atsushi, Hijikata Yasuhiro, Ito Daisuke, Kishimoto Yoshiyuki, Iida Madoka, Koike Haruki, Hirakawa Akihiro, Katsuno Masahisa
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 92 ( 10 ) page： 1072 - 1079 2021.10
Association of serum neurofilament light chain levels with clinicopathology of chronic inflammatory demyelinating polyneuropathy, including NF155 reactive patients
Fukami Yuki, Iijima Masahiro, Koike Haruki, Yamada Shinichiro, Hashizume Atsushi, Katsuno Masahisa
JOURNAL OF NEUROLOGY Vol. 268 ( 10 ) page： 3835 - 3844 2021.10
The Ultrastructure of Tissue Damage by Amyloid Fibrils
Koike Haruki, Katsuno Masahisa
MOLECULES Vol. 26 ( 15 ) 2021.8
Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment
Koike Haruki, Iguchi Yohei, Sahashi Kentaro, Katsuno Masahisa
MOLECULES Vol. 26 ( 16 ) 2021.8
Emerging infectious diseases, vaccines and Guillain-Barré syndrome.
Koike H, Katsuno M
Clinical & experimental neuroimmunology 2021.5
The role of macrophages in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy
Koike Haruki, Katsuno Masahisa
NEUROLOGY AND CLINICAL NEUROSCIENCE Vol. 9 ( 3 ) page： 203 - 210 2021.5
ANCA-associated neuropathy in systemic sclerosis: A case report and review of literature
Takenaka Kayo, Takeichi Takuya, Nishi Ryoji, Suzuki Masashi, Koike Haruki, Katsuno Masahisa, Ogawa-Momohara Mariko, Muro Yoshinao, Akiyama Masashi
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY Vol. 4 ( 2 ) page： 34 - 36 2021.4
The wide-ranging clinical and genetic features in Japanese families with valosin-containing protein proteinopathy
Ando Takashi, Nakamura Ryoichi, Kuru Satoshi, Yokoi Daichi, Atsuta Naoki, Koike Haruki, Suzuki Masashi, Hara Kazuhiro, Iguchi Yohei, Harada Yumiko, Yoshida Yusuke, Hattori Makoto, Murakami Ayuka, Noda Seiya, Kimura Seigo, Sone Jun, Nakamura Tomohiko, Goto Yoji, Mano Kazuo, Okada Hisashi, Okuda Satoshi, Nishino Ichizo, Ogi Tomoo, Sobue Gen, Katsuno Masahisa
NEUROBIOLOGY OF AGING Vol. 100 page： 120.e1 - 120.e6 2021.4
Macrophages and Autoantibodies in Demyelinating Diseases
Koike Haruki, Katsuno Masahisa
CELLS Vol. 10 ( 4 ) 2021.4
Limitations and benefits of FDG-PET/CT in NF1 patients with nerve sheath tumors: A cross-sectional/longitudinal study
Nishida Yoshihiro, Ikuta Kunihiro, Ito Shinji, Urakawa Hiroshi, Sakai Tomohisa, Koike Hiroshi, Ito Kan, Imagama Shiro
CANCER SCIENCE Vol. 112 ( 3 ) page： 1114 - 1122 2021.3
Two distinct mechanisms of neuropathy in immunoglobulin light chain (AL) amyloidosis.
Koike H, Mouri N, Fukami Y, Iijima M, Matsuo K, Yagi N, Saito A, Nakamura H, Takahashi K, Nakae Y, Okada Y, Tanaka F, Sobue G, Katsuno M
Journal of the neurological sciences Vol. 421 page： 117305 2021.2
Association Between IL-5 Levels and the Clinicopathologic Features of Eosinophilic Granulomatosis With Polyangiitis
Nishi Ryoji, Koike Haruki, Ohyama Ken, Fukami Yuki, Iijima Masahiro, Sobue Gen, Katsuno Masahisa
NEUROLOGY Vol. 96 ( 5 ) page： 226 - 229 2021.2
A New Resonance Calculation Method Using Energy Expansion Based on a Reduced Order Model
Kondo Ryoichi, Endo Tomohiro, Yamamoto Akio, Takeda Satoshi, Koike Hiroki, Yamaji Kazuya, Sato Daisuke
NUCLEAR SCIENCE AND ENGINEERING 2021.1
Aberrant Expression of Nodal and Paranodal Molecules in Neuropathy Associated With IgM Monoclonal Gammopathy With Anti-Myelin-Associated Glycoprotein Antibodies
Kawagashira Yuichi, Koike Haruki, Takahashi Mie, Ohyama Ken, Iijima Masahiro, Katsuno Masahisa, Niwa Jun-Ichi, Doyu Manabu, Sobue Gen
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY Vol. 79 ( 12 ) page： 1303 - 1312 2020.12
Pathophysiology of Chronic Inflammatory Demyelinating Polyneuropathy: Insights into Classification and Therapeutic Strategy
Koike Haruki, Katsuno Masahisa
NEUROLOGY AND THERAPY Vol. 9 ( 2 ) page： 213 - 227 2020.12
Characteristics of primary and repeated recurrent retroperitoneal liposarcoma: outcomes after aggressive surgeries at a single institution
Ishii Kenta, Yokoyama Yukihiro, Nishida Yoshihiro, Koike Hiroshi, Yamada Suguru, Kodera Yasuhiro, Sassa Naoto, Gotoh Momokazu, Nagino Masato
JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 50 ( 12 ) page： 1412 - 1418 2020.12
Association of serum neurofilament light chain levels with clinicopathology and NF155 autoantibodies in patients with CIDP
Fukami Yuki, Iijima Masahiro, Koike Haruki, Nishi Ryoji, Hashizume Atsushi, Katsuno Masahisa
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 25 ( 4 ) page： 464 - 465 2020.12
Transthyretin Amyloidosis: Update on the Clinical Spectrum, Pathogenesis, and Disease-Modifying Therapies
Koike Haruki, Katsuno Masahisa
NEUROLOGY AND THERAPY Vol. 9 ( 2 ) page： 317 - 333 2020.12
[A case of post-surgical inflammatory neuropathy with lower-extremity weakness after surgery for anorectal malignant melanoma that showed the effectiveness of immunotherapy].
Asano R, Kitazaki Y, Ikawa M, Kurebayasi H, Koike H, Hamano T
Rinsho shinkeigaku = Clinical neurology Vol. 60 ( 11 ) page： 762 - 767 2020.11
Desmoid with biweekly methotrexate and vinblastine shows similar effects to weekly administration: A phase II clinical trial
Nishida Yoshihiro, Hamada Shunsuke, Urakawa Hiroshi, Ikuta Kunihiro, Sakai Tomohisa, Koike Hiroshi, Ito Kan, Emoto Ryo, Ando Yuichi, Matsui Shigeyuki
CANCER SCIENCE Vol. 111 ( 11 ) page： 4187 - 4194 2020.11
Forced expression of KIAA1199, a novel hyaluronidase, inhibits tumorigenicity of low-grade chondrosarcoma
Koike Hiroshi, Nishida Yoshihiro, Shinomura Tamayuki, Zhuo Lisheng, Hamada Shunsuke, Ikuta Kunihiro, Ito Kan, Kimata Koji, Ushida Takahiro, Ishiguro Naoki
JOURNAL OF ORTHOPAEDIC RESEARCH Vol. 38 ( 9 ) page： 1942 - 1951 2020.9
Patisiran, an RNAi therapeutic for patients with hereditary transthyretin-mediated amyloidosis: Sub-analysis in Japanese patients from the APOLLO study
Yamashita Taro, Ueda Mitsuharu, Koike Haruki, Sekijima Yoshiki, Yoshinaga Tsuneaki, Kodaira Minori, Katsuno Masahisa, Sobue Gen, Zhang Xiaoping, White Matthew T., Sweetser Marianne T., Wang Jing Jing, Ando Yukio
NEUROLOGY AND CLINICAL NEUROSCIENCE Vol. 8 ( 5 ) page： 251 - 260 2020.9
Is tumour location a prognostic factor for pharmacological treatment in patients with desmoid-type fibromatosis? a systematic review
Koike Hiroshi, Hamada Shunsuke, Sakai Tomohisa, Shimizu Koki, Yoshida Masahiro, Nishida Yoshihiro
JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 50 ( 9 ) page： 1032 - 1036 2020.9
Is mutation analysis of beta-catenin useful for the diagnosis of desmoid-type fibromatosis? A systematic review
Sakai Tomohisa, Hamada Shunsuke, Koike Hiroshi, Shimizu Koki, Yoshida Masahiro, Nishida Yoshihiro
JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 50 ( 9 ) page： 1037 - 1042 2020.9
Cardiac metastases from primary myxoid liposarcoma of the thigh: a case report
Ikuta Kunihiro, Sakai Tomohisa, Koike Hiroshi, Okada Tohru, Imagama Shiro, Nishida Yoshihiro
WORLD JOURNAL OF SURGICAL ONCOLOGY Vol. 18 ( 1 ) 2020.8
Risk factors of local recurrence after surgery in extraabdominal desmoid-type fibromatosis: A multicenter study in Japan
Nishida Yoshihiro, Hamada Shunsuke, Kawai Akira, Kunisada Toshiyuki, Ogose Akira, Matsumoto Yoshihiro, Ae Keisuke, Toguchida Junya, Ozaki Toshifumi, Hirakawa Akihiro, Motoi Toru, Sakai Tomohisa, Kobayashi Eisuke, Gokita Tabu, Okamoto Takeshi, Matsunobu Tomoya, Shimizu Koki, Koike Hiroshi
CANCER SCIENCE Vol. 111 ( 8 ) page： 2935 - 2942 2020.8
Monitoring of asymptomatic family members at risk of hereditary transthyretin amyloidosis for early intervention with disease-modifying therapies
Ueda Mitsuharu, Sekijima Yoshiki, Koike Haruki, Yamashita Taro, Yoshinaga Tsuneaki, Ishii Tomonori, Ando Yukio
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 414 page： 116813 2020.7
Ultrastructural mechanisms of macrophage-induced demyelination in Guillain-Barre syndrome
Koike Haruki, Fukami Yuki, Nishi Ryoji, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 91 ( 6 ) page： 650 - 659 2020.6
Differential clinicopathologic features of EGPA-associated neuropathy with and without ANCA
Nishi Ryoji, Koike Haruki, Ohyama Ken, Fukami Yuki, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
NEUROLOGY Vol. 94 ( 16 ) page： E1726 - E1737 2020.4
Efficacy and Safety of Rituximab in Refractory CIDP With or Without IgG4 Autoantibodies (RECIPE): Protocol for a Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Shimizu Shinobu, Iijima Masahiro, Fukami Yuki, Tamura Natsuko, Nakatochi Masahiro, Ando Masahiko, Nishi Ryoji, Koike Haruki, Kaida Kenichi, Koga Michiaki, Kanda Takashi, Ogata Hidenori, Kira Jun-Ichi, Mori Masahiro, Kuwabara Satoshi, Katsuno Masahisa
JMIR RESEARCH PROTOCOLS Vol. 9 ( 4 ) page： e17117 2020.4
Efficacy of low-dose chemotherapy with methotrexate and vinblastine for patients with extra-abdominal desmoid-type fibromatosis: a systematic review
Shimizu Koki, Hamada Shunsuke, Sakai Tomohisa, Koike Hiroshi, Yoshida Masahiro, Nishida Yoshihiro
JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 50 ( 4 ) page： 419 - 424 2020.4
Red-shifted chlorophyll a bands allow uphill energy transfer to photosystem II reaction centers in an aerial green alga, Prasiola crispa, harvested in Antarctica
Kosugi Makiko, Ozawa Shin-Ichiro, Takahashi Yuichiro, Kamei Yasuhiro, Itoh Shigeru, Kudoh Sakae, Kashino Yasuhiro, Koike Hiroyuki
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS Vol. 1861 ( 2 ) 2020.2
Complement deposition and macrophage-induced demyelination in CIDP with anti-LM1 antibodies
Koike Haruki, Ikeda Shohei, Fukami Yuki, Nishi Ryoji, Kawagashira Yuichi, Iijima Masahiro, Nakamura Tomohiko, Kuwahara Motoi, Kusunoki Susumu, Katsuno Masahisa, Sobue Gen
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 408 page： 116509 2020.1
Expanding the spectrum of transthyretin amyloidosis
Koike Haruki, Katsuno Masahisa
MUSCLE & NERVE Vol. 61 ( 1 ) page： 3 - 4 2020.1
Expanding the spectrum of transthyretin amyloidosis.
Koike H, Katsuno M
Muscle & nerve Vol. 61 ( 1 ) page： 3 - 4 2020.1
Demyelinating Neuropathy Due to Intravascular Large B-cell Lymphoma
Fukami Yuki, Koike Haruki, Iijima Masahiro, Hagita Junichirou, Niwa Hisayoshi, Nishi Ryoji, Kawagashira Yuichi, Katsuno Masahisa
INTERNAL MEDICINE Vol. 59 ( 3 ) page： 435 - 438 2020
Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin
Kusama Kaori, Nakae Yoshiharu, Tada Mikiko, Higashiyama Yuichi, Miyaji Yosuke, Yamaura Genpei, Kunii Misako, Tanaka Kenichi, Ohyama Ken, Koike Haruki, Joki Hideto, Doi Hiroshi, Koyano Shigeru, Tanaka Fumiaki
INTERNAL MEDICINE Vol. 59 ( 23 ) page： 3075 - 3078 2020
MRI characteristics predict the efficacy of meloxicam treatment in patients with desmoid-type fibromatosis
Shimizu Koki, Hamada Shunsuke, Sakai Tomohisa, Ito Shinji, Urakawa Hiroshi, Arai Eisuke, Ikuta Kunihiro, Koike Hiroshi, Ishiguro Naoki, Nishida Yoshihiro
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY Vol. 63 ( 6 ) page： 751 - 757 2019.12
Expanding the spectrum of transthyretin amyloidosis
Koike Haruki, Katsuno Masahisa
MUSCLE & NERVE 2019.11
Intractable axonal neuropathy with multifocal peripheral nerve swelling in neuromyelitis optica spectrum disorders: A case report
Mizuno Yuri, Shinoda Koji, Watanabe Mitsuru, Ogata Hidenori, Isobe Noriko, Matsushita Takuya, Yamasaki Ryo, Tanaka Kimihiro, Koike Haruki, Katsuno Masahisa, Kira Jun-ichi
MULTIPLE SCLEROSIS AND RELATED DISORDERS Vol. 35 page： 16 - 18 2019.10
Pazopanib for progressive desmoid tumours: children, persistant effects, and cost
Nishida Yoshihiro, Sakai Tomohisa, Koike Hiroshi, Ito Kan
LANCET ONCOLOGY Vol. 20 ( 10 ) page： E555 - E555 2019.10
[Multiple mononeuropathy associated with systemic sclerosis with vasculitis confirmed by nerve biopsy: a case report].
Kano Y, Kato H, Koike H, Katsuno M, Oguri T, Yuasa H
Rinsho shinkeigaku = Clinical neurology Vol. 59 ( 9 ) page： 604 - 606 2019.9
Clinicopathological characteristics of subtypes of chronic inflammatory demyelinating polyradiculoneuropathy
Ikeda Shohei, Koike Haruki, Nishi Ryoji, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 90 ( 9 ) page： 988 - 996 2019.9
Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease
Sone Jun, Mitsuhashi Satomi, Fujita Atsushi, Mizuguchi Takeshi, Hamanaka Kohei, Mori Keiko, Koike Haruki, Hashiguchi Akihiro, Takashima Hiroshi, Sugiyama Hiroshi, Kohno Yutaka, Takiyama Yoshihisa, Maeda Kengo, Doi Hiroshi, Koyano Shigeru, Takeuchi Hideyuki, Kawamoto Michi, Kohara Nobuo, Ando Tetsuo, Ieda Toshiaki, Kita Yasushi, Kokubun Norito, Tsuboi Yoshio, Katoh Kazutaka, Kino Yoshihiro, Katsuno Masahisa, Iwasaki Yasushi, Yoshida Mari, Tanaka Fumiaki, Suzuki Ikuo K., Frith Martin C., Matsumoto Naomichi, Sobue Gen
NATURE GENETICS Vol. 51 ( 8 ) page： 1215 - + 2019.8
Clinicopathological spectrum and recent advances in the treatment of hereditary transthyretin amyloidosis
Koike Haruki, Fukami Yuki, Nishi Ryoji, Kawagashira Yuichi, Iijima Masahiro, Sobue Gen, Katsuno Masahisa
NEUROLOGY AND CLINICAL NEUROSCIENCE Vol. 7 ( 4 ) page： 166 - 173 2019.7
Hereditary transthyretin amyloidosis: a model of medical progress for a fatal disease
Adams David, Koike Haruki, Slama Michel, Coelho Teresa
NATURE REVIEWS NEUROLOGY Vol. 15 ( 7 ) page： 387 - 404 2019.7
Vasculitic neuropathy with anti-phosphatidylserine/prothrombin complex antibody
Ando Takashi, Iijima Masahiro, Fukami Yuki, Nishi Ryoji, Ikeda Shohei, Yokoi Satoshi, Kawagashira Yuichi, Koike Haruki, Muro Yoshinao, Katsuno Masahisa
MUSCLE & NERVE Vol. 59 ( 6 ) page： E44 - E46 2019.6
Diagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithm (vol 13, pg 6, 2018)
Sekijima Yoshiki, Ueda Mitsuharu, Koike Haruki, Misawa Sonoko, Ishii Tomonori, Ando Yukio
ORPHANET JOURNAL OF RARE DISEASES Vol. 14 ( 1 ) page： 111 2019.5
DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5
Kondo Naohide, Tohnai Genki, Sahashi Kentaro, Iida Madoka, Kataoka Mayumi, Nakatsuji Hideaki, Tsutsumi Yutaka, Hashizume Atsushi, Adachi Hiroaki, Koike Haruki, Shinjo Keiko, Kondo Yutaka, Sobue Gen, Katsuno Masahisa
EMBO MOLECULAR MEDICINE Vol. 11 ( 5 ) 2019.5
Cardiac and peripheral vasomotor autonomic functions in hereditary transthyretin amyloidosis with non-Val30Met mutation
Koike Haruki, Nakamura Tomohiko, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS Vol. 26 ( sup1 ) page： 13 - 14 2019.3
Evolution of amyloid fibrils in hereditary transthyretin amyloidosis: an ultrastructural study
Koike Haruki, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS Vol. 26 ( sup1 ) page： 26 - 26 2019.3
Common clinicopathological features in late-onset hereditary transthyretin amyloidosis (Ala97Gly, Val94Gly and Val30Met)
Koike Haruki, Nakamura Tomohiko, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Yasuda Takeshi, Mukai Eiichiro, Date Yukari, Shiomi Kazutaka, Nakazato Masamitsu, Katsuno Masahisa, Sobue Gen
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS Vol. 26 ( sup1 ) page： 24 - 25 2019.3
Cardiovascular autonomic functions in late-onset hereditary transthyretin amyloidosis with Val30Met mutation
Nakamura Tomohiko, Koike Haruki, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS Vol. 26 ( sup1 ) page： 6 - 6 2019.3
Ultrastructure in Transthyretin Amyloidosis: From Pathophysiology to Therapeutic Insights.
Koike H, Katsuno M
Biomedicines Vol. 7 ( 1 ) 2019.2
New teased-fibre definitions represent specific mechanisms of neuropathy.
Koike H, Katsuno M, Sobue G
Journal of neurology, neurosurgery, and psychiatry Vol. 90 ( 2 ) page： 124 - 124 2019.2
Is immunohistochemical staining for beta-catenin the definitive pathological diagnostic tool for desmoid-type fibromatosis? A multi-institutional study
Koike Hiroshi, Nishida Yoshihiro, Kohno Kei, Shimoyama Yoshie, Motoi Toru, Hamada Shunsuke, Kawai Akira, Ogose Akira, Ozaki Toshifumi, Kunisada Toshiyuki, Matsumoto Yoshihiro, Matsunobu Tomoya, Ae Keisuke, Gokita Tabu, Sakai Tomohisa, Shimizu Koki, Ishiguro Naoki
HUMAN PATHOLOGY Vol. 84 page： 155 - 163 2019.2
Pathology of familial amyloid polyneuropathy
Koike Haruki
BRAIN PATHOLOGY Vol. 29 page： 61 - 61 2019.2
Ultrastructural mechanisms of macrophage-induced demyelination in chronic inflammatory demyelinating polyneuropathy: an observation on longitudinal sections
Koike Haruki, Fukami Yuki, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
BRAIN PATHOLOGY Vol. 29 page： 53 - 54 2019.2
Vasculopathy in hereditary transthyretin amyloidosis: an electron microscopic study
Koike Haruki, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Misumi Yohei, Ando Yukio, Ikeda Shu-ichi, Katsuno Masahisa, Sobue Gen
BRAIN PATHOLOGY Vol. 29 page： 29 - 29 2019.2
Nerve Ultrasound, Electrophysiological, and Clinical Changes in Treatment-Naive Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report.
Sato T, Terasawa Y, Higa H, Matsuno H, Arai A, Omoto S, Mitsumura H, Toyoda C, Koike H, Iguchi Y
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society Vol. 36 ( 1 ) page： 82 - 84 2019.1
Myelopathy and Neuropathy Associated With Alcoholism
Koike Haruki
NEUROSCIENCE OF ALCOHOL: MECHANISMS AND TREATMENT page： 195 - 205 2019
Ultrastructural mechanisms of macrophage-induced demyelination in CIDP
Koike Haruki, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
NEUROLOGY Vol. 91 ( 23 ) page： 1051-1060 2018.12
Clinicopathological features of eosinophilic granulomatosis with polyangiitis with and without anti-neutrophil cytoplasmic antibodies
Nishi Ryoji, Koike Haruki, Ikeda Shohei, Ohyama Ken, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 23 ( 4 ) page： 348-348 2018.12
Ultrastructural mechanisms of macrophage-induced demyelination in chronic inflammatory demyelinating polyneuropathy
Koike Haruki, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 23 ( 4 ) page： 364-365 2018.12
Evolution of amyloid fibrils in transthyretin familial amyloid polyneuropathy: An ultrastructural study
Koike Haruki, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 23 ( 4 ) page： 321-321 2018.12
The morphology of amyloid fibrils and their impact on tissue damage in hereditary transthyretin amyloidosis: An ultrastructural study
Koike Haruki, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Sakurai Takeo, Shimohata Takayoshi, Katsuno Masahisa, Sobue Gen
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 394 page： 99-106 2018.11
Recurrent autonomic and sensory neuropathy in a patient with anti-ganglionic acetylcholine receptor antibodies.
Watanabe E, Fujita T, Shimono M, Koike H, Yasumoto S, Hirose S
eNeurologicalSci Vol. 12 page： 36 - 38 2018.9
Safety and efficacy of eculizumab in Guillain-Barre syndrome: a multicentre, double-blind, randomised phase 2 trial
Misawa Sonoko, Kuwabara Satoshi, Sato Yasunori, Yamaguchi Nobuko, Nagashima Kengo, Katayama Kanako, Sekiguchi Yukari, Iwai Yuta, Amino Hiroshi, Suichi Tomoki, Yokota Takanori, Nishida Yoichiro, Kanouchi Tadashi, Kohara Nobuo, Kawamoto Michi, Ishii Junko, Kuwahara Motoi, Suzuki Hidekazu, Hirata Koichi, Kokubun Norito, Masuda Ray, Kaneko Juntaro, Yabe Ichiro, Sasaki Hidenao, Kaida Ken-ichi, Takazaki Hiroshi, Suzuki Norihiro, Suzuki Shigeaki, Nodera Hiroyuki, Matsui Naoko, Tsuji Shoji, Koike Haruki, Yamasaki Ryo, Kusunoki Susumu
LANCET NEUROLOGY Vol. 17 ( 6 ) page： 519 - 529 2018.6
Suppression of hyaluronan synthesis attenuates the tumorigenicity of low-grade chondrosarcoma
Hamada Shunsuke, Nishida Yoshihiro, Zhuo Lisheng, Shinomura Tamayuki, Ikuta Kunihiro, Arai Eisuke, Koike Hiroshi, Kimata Koji, Ushida Takahiro, Ishiguro Naoki
JOURNAL OF ORTHOPAEDIC RESEARCH Vol. 36 ( 6 ) page： 1573-1580 2018.6
Long-standing overt ventriculomegaly without aqueductal stenosis: A case report
Ikumi Kazuhiro, Tsuboi Takashi, Atsuta Naoki, Takeuchi Kazuhito, Koike Haruki, Katsuno Masahisa
NEUROLOGY AND CLINICAL NEUROSCIENCE Vol. 6 ( 2 ) page： 42-44 2018.3
[Zika Virus and Guillain-Barré Syndrome].
Vol. 70 ( 2 ) page： 113-120 2018.2
Diagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithm
Sekijima Yoshiki, Ueda Mitsuharu, Koike Haruki, Misawa Sonoko, Ishii Tomonori, Ando Yukio
ORPHANET JOURNAL OF RARE DISEASES Vol. 13 ( 1 ) page： 6 2018.1
First nationwide survey on systemic wild-type ATTR amyloidosis in Japan
Sekijima Yoshiki, Yazaki Masahide, Ueda Mitsuharu, Koike Haruki, Yamada Masahito, Ando Yukio
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS Vol. 25 ( 1 ) page： 8-10 2018
Widespread Cardiac and Vasomotor Autonomic Dysfunction in Non-Val30Met Hereditary Transthyretin Amyloidosis
Koike Haruki, Nakamura Tomohiko, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
INTERNAL MEDICINE Vol. 57 ( 23 ) page： 3365-3370 2018
Systemic angiopathy and axonopathy in hereditary transthyretin amyloidosis with Ala97Gly (p. Ala117Gly) mutation: a post-mortem analysis
Koike Haruki, Yasuda Takeshi, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Sobue Gen, Katsuno Masahisa
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS Vol. 25 ( 2 ) page： 141-142 2018
Restoration of a Conduction Block after the Long-term Treatment of CIDP with Anti-neurofascin 155 Antibodies: Follow-up of a Case over 23 Years
Koike Haruki, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Atsuta Naoki, Nakamura Tomohiko, Hirayama Masaaki, Ogata Hidenori, Yamasaki Ryo, Kira Jun-ichi, Katsuno Masahisa, Sobue Gen
INTERNAL MEDICINE Vol. 57 ( 14 ) page： 2061-2066 2018
Radially and azimuthally dependent resonance self-shielding treatment for general multi-region geometry based on a unified theory
Koike Hiroki, Kirimura Kazuki, Yamaji Kazuya, Kosaka Shinya, Yamamoto Akio
JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Vol. 55 ( 1 ) page： 41-65 2018
Cardiac and peripheral vasomotor autonomic functions in late-onset transthyretin Val30Met familial amyloid polyneuropathy
Koike Haruki, Nakamura Tomohiko, Hashizume Atsushi, Nishi Ryoji, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
JOURNAL OF NEUROLOGY Vol. 264 ( 11 ) page： 2293-2302 2017.11
Distinct pathogenesis in nonsystemic vasculitic neuropathy and microscopic polyangiitis
Takahashi Mie, Koike Haruki, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Hashizume Atsushi, Katsuno Masahisa, Sobue Gen
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION Vol. 4 ( 6 ) page： e407 2017.11
Clinicopathological features of CIDP subtypes
Ikeda S., Nishi R., Kawagashira Y., Iijima M., Koike H., Katsuno M., Sobue G.
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 465-466 2017.10
Vasculopathy in familial amyloid polyneuropathy
Koike H., Nishi R., Ikeda S., Kawagashira Y., Iijima M., Misumi Y., Ando Y., Ikeda S. I., Katsuno M., Sobue G.
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 475-476 2017.10
Reinnervation after denervation in inclusion body myositis
Noda S., Koike H., Nakanishi H., Kimura S., Katsuno M.
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 825-826 2017.10
Paranodal axo-glial detachment in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies
Koike H., Kadoya M., Kaida K. I., Nishi R., Ikeda S., Kawagashira Y., Lijima M., Kato D., Ogata H., Yamasaki R., Matsukawa N., Kira J. I., Katsuno M., Sobue G.
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 59 - 60 2017.10
Mediterranean fever gene mutations in patients with central nervous inflammation diagnosed with possible neuro-sweet disease
Iijima M., Nishi R., Ikeda S., Kawagashira Y., Koike H., Katsuno M., Sobue G.
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 541-541 2017.10
Diagnostic value of muscle biopsy for neuromuscular diseases
Kimura S., Nakanishi H., Noda S., Murakami A., Iijima M., Koike H., Katsuno M.
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 473-474 2017.10
Diagnostic utility of ELBA for anti-neurofascin 155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy
Kaida K., Kadoya M., Koike H., Iijima M., Takazaki H., Ogata H., Moriguchi K., Shimizu J., Nagata E., Takizawa S., Chiba A., Yamasaki R., Kira J., Sobue G., Ikewaki K.
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 470-471 2017.10
Clinicopathological features of eosinophilic granulomatosis with polyangiitis with and without antineutrophil cytoplasmic antibodies
Nishi R., Koike H., Ikeda S., Ohyama K., Kawagashira Y., Iijima M., Katsuno M., Sobue G.
JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 825-825 2017.10
ANTIBODIES TO NEUROFASCIN155 IN CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY: DIAGNOSTIC UTILITY OF A CONVENTIONAL ASSAY
Kaida K., Kadoya M., Koike H., Iijima M., Takazaki H., Ogata H., Moriguchi K., Shimizu J., Nagata E., Takizawa S., Chiba A., Yamasaki R., Kira J- I, Sobue G., Ikewaki K.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 22 ( 3 ) page： 311-311 2017.9
SCHWANN CELL AND ENDOTHELIAL CELL DAMAGE IN TRANSTHYRETIN FAMILIAL AMYLOID POLYNEUROPATHY
Koike H., Ikeda S., Takahashi M., Kawagashira Y., Iijima M., Misumi Y., Ando Y., Ikeda S. I., Katsuno M., Sobue G.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 22 ( 3 ) page： 318-318 2017.9
PARANODAL DISSECTION IN CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY WITH ANTI-NEUROFASCIN 155 AND ANTI-CONTACTIN 1 ANTIBODIES
Koike H., Kadoya M., Kaida K., Ikeda S., Kawagashira Y., Iijima M., Kato D., Ogata H., Yamasaki R., Matsukawa N., Kira J. I, Katsuno M., Sobue G.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 22 ( 3 ) page： 318-318 2017.9
EFFICACY OF IMMUNOGLOBULINS FOR NOD B7-2 KO MICE
Iijima M., Nishi R., Ikeda S., Kawagashira Y., Koike H., Sobue G., Katsuno M.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 22 ( 3 ) page： 303-303 2017.9
CLINICOPATHOLOGICAL FEATURES AMONG CIDP SUBTYPES
Ikeda S., Nishi R., Kawagashira Y., Iijima M., Koike H., Katsuno M., Sobue G.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM Vol. 22 ( 3 ) page： 303-304 2017.9
Immunohistochemical staining with non-phospho beta-catenin as a diagnostic and prognostic tool of COX-2 inhibitor therapy for patients with extra-peritoneal desmoid-type fibromatosis
Sakai Tomohisa, Nishida Yoshihiro, Hamada Shunsuke, Koike Hiroshi, Ikuta Kunihiro, Ota Takehiro, Ishiguro Naoki
DIAGNOSTIC PATHOLOGY Vol. 12 2017.8
Reply: Neuronal intranuclear (hyaline) inclusion disease and fragile X-associated tremor/ataxia syndrome: a morphological and molecular dilemma
Sone Jun, Nakamura Tomohiko, Koike Haruki, Katsuno Masahisa, Tanaka Fumiaki, Iwasaki Yasushi, Yoshida Mari, Sobue Gen
BRAIN Vol. 140 ( 8 ) page： E52 - + 2017.8
Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies
Koike Haruki, Kadoya Masato, Kaida Ken-ichi, Ikeda Shohei, Kawagashira Yuichi, Iijima Masahiro, Kato Daisuke, Ogata Hidenori, Yamasaki Ryo, Matsukawa Noriyuki, Kira Jun-ichi, Katsuno Masahisa, Sobue Gen
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 88 ( 6 ) page： 465-473 2017.6
TRANSFORMING GROWTH FACTOR-beta SIGNALING IS UPREGULATED IN SPORADIC INCLUSION BODY MYOSITIS
Noda Seiya, Koike Haruki, Maeshima Shinya, Nakanishi Hirotaka, Iijima Masahiro, Matsuo Koji, Kimura Seigo, Katsuno Masahisa, Sobue Gen
MUSCLE & NERVE Vol. 55 ( 5 ) page： 741-747 2017.5
Diagnostic flowchart of adult-onset neuronal intranuclear inclusion disease
Sone Jun, Mori Keiko, Koike Haruki, Nakamura Tomohiko, Masuda Michihito, Yoshida Mari, Iwasaki Yasushi, Tanaka Fumiaki, Katsuno Masahisa, Sobue Gen
NEUROLOGY Vol. 88 2017.4
Disruption of blood-nerve barriers in hereditary transthyretin (ATTR) amyloidosis
Koike Haruki, Ikeda Shohei, Takahashi Mie, Kawagashira Yuichi, Iijima Masahiro, Misumi Yohei, Ando Yukio, Ikeda Shu-ichi, Katsuno Masahisa, Sobue Gen
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS Vol. 24 ( sup1 ) page： 89-90 2017.3
Alcoholic Myelopathy and Nutritional Deficiency
Koike Haruki, Nakamura Tomohiko, Ikeda Shohei, Takahashi Mie, Kawagashira Yuichi, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
INTERNAL MEDICINE Vol. 56 ( 1 ) page： 105-108 2017
Vasculitic Neuropathy Following Exposure to a Glyphosate-based Herbicide
Kawagashira Yuichi, Koike Haruki, Kawabata Kazuya, Takahashi Mie, Ohyama Ken, Hashimoto Rina, Iijima Masahiro, Katsuno Masahisa, Sobue Gen
INTERNAL MEDICINE Vol. 56 ( 11 ) page： 1431-1434 2017
Wide range of clinicopathological features in immune-mediated autonomic neuropathies.
Koike H, Sobue G
Vol. 4 ( 1 ) page： 46-59 2013
What is the prototype of familial amyloid polyneuropathy?
5) Koike H, Sobue G
J Neurol Neurosurg Psychiatry Vol. 85 ( 7 ) page： 713 2013
Demyelinating neuropathy and autoimmune hemolytic anemia in a patient with pancreatic cancer.
Koike H, Yoshida H, Ito T, Ohyama K, Hashimoto R, Kawagashira Y, Iijima M, Sobue G
Intern Med Vol. 52 ( 15 ) page： 1737-40 2013
The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features.
Koike H, Watanabe H, Sobue G
J Neurol Neurosurg Psychiatry Vol. 84 ( 1 ) page： 98-106 2013
The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features
Koike H, Watanabe H, Sobue G
J Neurol Neurosurg Psychiatry Vol. 84 ( 1 ) page： 98-106 2012.8
Grant number：20K07882 2020.4 - 2023.3
科学研究費助成事業 基盤研究(C)
小池 春樹, 勝野 雅央, 飯島 正博
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
本研究ではNSVNの臨床病理像を明らかにするとともに、疾患マーカーとなる抗体の探索や治療反応性の検討などを行う。はじめに、患者レジストリを構築してNSVNの臨床病理像の検討を行う。抗体の探索ではマウスの神経組織と患者血清で特異的に反応する蛋白質の同定を行い、自己抗体が認識する抗原を同定した後、自己抗原の組織内分布を解析する。抗原候補蛋白をマウスに投与することによってNSVNモデルマウスを作成し、病態解析を行う。さらに、NSVNにおけるエクリズマブのにおける有効性と安全性についても検討する。
血管炎は様々な原因で発症し、神経障害、特に末梢神経障害（ニューロパチー）を高頻度にきたすことが知られている。急性または亜急性に進行する場合が多く、治療により原疾患を寛解に導いても神経障害が残存することも多いことから、早期からの治療介入が必要な疾患である。末梢神経系のみが障害される非全身性血管炎性ニューロパチー（non-systemic vasculitic neuropathy; NSVN）は1987年にDyckらによって初めて報告された概念であり、顕微鏡的多発血管炎と並んで血管炎によるニューロパチーの主要な原因と考えられるようになっている。しかし、NSVNは非特異的なニューロパチーの病像を呈し、血液検査でもCRP値や血沈も含めて異常所見に乏しいことから診断に難渋する場合が多い。さらに治療反応性を示すマーカーもないことから、治療方針の確立も困難である。このことから、NSVNの早期診断、早期治療につなげることのできるバイオマーカーを明らかにする必要がある。
本研究ではNSVNの臨床病理像を、日常診療の場で鑑別が問題となる顕微鏡的多発血管炎と比較することにより全身性血管炎との連続性を明らかにするとともに、疾患マーカーとなる抗体の探索や前向きの治療反応性の検討などを行う。はじめに、患者レジストリを構築してNSVNの長期予後も含めた臨床像・病理像の検討を行う。特に、顕微鏡的多発血管炎による末梢神経障害と比較することによって全身性血管炎との連続性を明らかにする。抗体の探索ではマウスの神経組織と患者血清で特異的に反応する蛋白質の同定を行い、自己抗体が認識する抗原エピトープを同定した後、自己抗原の組織内分布を解析する。抗原候補蛋白をマウスに投与することによってNSVNモデルマウスを作成し、病態解析を行う。さらに、NSVNにおけるエクリズマブのにおける有効性と安全性についても検討する。
名古屋大学神経内科にコンサルテーションのあった症例も含めて発症年齢、初発症状、進行期間、障害の進展様式、重症度などの臨床像、および治療反応性も含めた長期予後を検討し、顕微鏡的多発血管炎に伴うニューロパチー、特にANCA陰性例と比較した。NSVNに関しては今後も新規の症例のconsultationが年間10例程度はあると予想され、最終的には50例程度での長期予後の検討を行う方針である。具体的には当院で診断したNSVN症例の既存例も含めた登録システムを構築して、臨床症候・電気生理学的検査所見・血液検査所見などの前向きの情報収集と生体試料のサンプリングを定期的に行う。さらに、腓腹神経生検の検体を用いて有髄線維密度と無髄線維密度の測定を含めた形態学的検討を行うとともに、ホルマリン固定および凍結の検体を用いて免疫組織化学的検討を行った。具体的には、顕微鏡的多発血管炎の初期病変といわれているANCA陽性好中球の小血管内皮への接着に伴う内皮細胞の障害の有無を光顕レベルでの検討、および電顕を用いた超微形態学的な検討にて確認した。NSVNと顕微鏡的多発血管炎では両者ともに壊死性血管炎の所見が見られるものの、血管内皮に接着した好中球はNSVNではほとんど認めないのに対し、顕微鏡的多発血管炎では多く見られ、後者では抗好中球細胞質抗体が病態に重要な役割を果たしていることが推測された。一方、補体の沈着をC3、C4、C5、MACなどに対する抗体を用いて検討したところ、顕微鏡的多発血管炎と比較してNSVNで補体沈着が多く見られたことからNSVNにおける補体を介した病態の重要性が示唆された。さらに末梢神経系における血管炎は神経上膜の細血管で生じることから、画像解析ソフトを用いて神経上膜の面積を測定し、好中球の接着や補体が沈着血管の数を定量化して顕微鏡的多発血管炎に伴うニューロパチーと比較した。
NSVNの長期予後も含めた臨床像・病理像の検討に関しては今後も継続していく。症例のリクルートに関しては、名古屋大学大学院医学系研究科には、NSVNのみならず血管炎関連疾患全般に関して多数の生検および剖検例の蓄積がある。また、NSVNの認知度の高まりにつれて、今後も新規の症例が多数加わることが予想され、多数例での臨床病理学的なアプローチのみならず、治療反応性も含めた前向きの臨床研究も可能となる。免疫組織化学的検討や免疫電顕に必要な光学および電子顕微鏡をはじめとする機器は神経内科学教室および分析機器部門に設置されており、今後も本研究のために積極的に活用していく。これらの研究から得られた知見をもとに、NSVNを発症させる標的抗原の確定とモデルマウスの解析、治療への展開を目指す。本研究の研究分担者および研究協力者は研究代表者と同一の施設に在籍し、定期的に連絡調整を行っている。研究分担者の飯島正博は他の研究協力者とともに末梢神経疾患の生検/剖検検体を用いた病態解析とモデルマウスの解析を行っている。モデルマウスの解析手法は研究分担者である勝野雅央らによって確立されており、この手法を活用する。また、研究成果は国内および海外での学会で積極的に発表するとともに、名古屋大学神経内科ホームページ、機会があれば報道機関などを通して研究成果を社会・国民に発信していく。
以上のような計画遂行で、NSVNの病態を究明し新規治療法の開発へつなげることができると考える。
免疫介在性ニューロパチーの疾患活動性を反映する新規バイオマーカーの開発
Grant number：20K07864 2020.4 - 2023.3
科学研究費助成事業 基盤研究(C)
飯島 正博, 小池 春樹, 勝野 雅央
Authorship：Coinvestigator(s)
本研究の狙いは免疫介在性ニューロパチーの治療適正化である。CIDP患者の病極期における生検神経から遺伝子発現プロファイルを作成する。また軸索障害を反映するニューロフィラメント-lightによる病態活動性マーカーの有用性を検証する。さらに動物モデルの免疫担当細胞のpopulation解析から病態最上流のpopulationを特定し、これらの免疫学的ネットワークの解明を目指す。
本研究の狙いは免疫介在性ニューロパチーの治療適正化である。神経領域疾患におけるニューロフィラメント-light（NF-L）は軸索障害を反映するマーカーとして期待されるが、本研究では代表的な免疫介在性ニューロパチーであるCIDPにおいて微量なNF-Lを血清から測定することで、侵襲の少ない病態活動性マーカーとしての有用性を検証する。これまでに58例のCIDP患者の病極期ならびに治療後における血清NF-Lを測定し、CIDPの各亜型と正常コントロール例、臨床スコア、神経伝導検査所見、神経生検の病理所見との関連性を解析した。その結果、NF-Lは正常コントロールより有意な増加を示すとともに、mRSスコアと髄液蛋白と正の相関を認めた。またIgG4自己抗体（抗NF155抗体）陽性例は陰性例より高値を示した。神経伝導検査所見では、NF-Lは脛骨神経の複合筋活動電位振幅と負の相関を示し、神経生検の病理所見からは軸索変性に強い相関を示した。
また、本研究のもう一つの課題として、CIDPマウスモデルの免疫担当細胞のpo pulation解析から病態最上流のpopulationを特定し、これらの免疫学的ネットワークの解明を目指している。これまでに発症前より病変部坐骨神経においてCD4陽性T細胞とCD68陽性細胞の出現が確認され、これらは相互にmergeする傾向を示した。その後の病極期付近でCD19陽性B細胞が出現するが、FCM解析からこれらはBregに分類されるpopulationが含まれる可能性が示されている。またCD8陽性T細胞はCD4, CD68陽性細胞とは独立して中期より病変部への浸潤が認められた。これより、病態の初期にはマクロファージもしくはAPCとCD4陽性T細胞が病態の主座を担う可能性が示唆され、その後は他のpopulationによる病勢修飾や病態の移行の可能性が示唆された。
本研究は2つのアプローチにより、CIDPをはじめとする免疫介在性ニューロパチーの病態解明と新規バイオマーカー候補を探索する。１つはCIDP患者血清を用いた超精密ELISA（Simoa system）によりCIDPにおけるNF-Lの変動を鑑別疾患ならびに各亜型間で重症度、神経伝導検査、生検病理所見との相関解析により評価し、疾患活動性・病勢評価としての有用性を検証した。これらはすでに論文（J Neurol. 2021. doi: 10.1007/s00415-021-10537-2., online ahead of print）されたことから、本研究は当初の計画以上に進展している。
また、CIDPモデルマウスを用いた評価についても、当初計画した各病期における病態を構成する免疫populationの解析は完了し、治療的介入試験として生理食塩水をコントロールとして、完全型免疫グロブリン腹腔内投与時における臨床症状や坐骨神経における病理解析、さらに同部位における浸潤免疫細胞のpopulation解析を行いつつあり、こちらも当初の計画以上の進展を得ている。
CIDPにおいて多くの患者血清を有することから、今回の対象であるNF-L以外にCIDPの病勢や臨床像を反映するバイオマーカー探索を行う予定である。人ならびにマウスサンプルにCIDP患者血清を反応させた候補バンドを切り出し、質量解析により候補分子を特定する。すでに複数の候補分子が特定されつつあり、なかでも候補分子XについてはELISAならびにウェスタンブロット法による患者血清との反応性も確認しており、CIDPの特定の亜型におけるあらたな診断的バイオマーカーの可能性と病因としての検証を今後試みる予定である。
CIDPマウスモデルに関しては、完全型グロブリンによる免疫修飾を確認したことから、今後はFcやF(ab')2といった断片化グロブリンを人為的に作製して投与することで、どの断片が免疫修飾能を有するかの検証を試みる予定である。
Deciphering the mechanism of neuropathy and development of novel therapies in familial amyloid polyneuropathy
Grant number：17K09777 2017.4 - 2020.3
Koike Haruki
Authorship：Principal investigator
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
Transthyretin (TTR) Val30Met familial amyloid polyneuropathy (FAP) (FAP ATTR Val30Met) is the most common type of FAP. Long amyloid fibers were abundant in the conventional early-onset Val30Met cases from endemic foci, whereas the amyloid fibrils were generally short in the late-onset Val30Met and non-Val30Met cases from non-endemic areas. The distortion of Schwann cells close to amyloid fibril masses was conspicuous, particularly in cases with long amyloid fibrils. Findings suggestive of the disruption of blood-nerve barriers, such as the loss of tight junctions and the fenestration of endothelial cells, were frequently found particularly in late-onset FAP cases. These findings suggest that direct insult of amyloid fibrils causes Schwann cell damage resulting in the predominant loss of small-fiber axons characteristic of early onset cases. In addition, vasculopathy may also participate in the pathogenesis of neuropathy, particularly in late onset cases.
Elucidation of the axonal degenerative mechanism focusing on the paranodal molecules in immune-mediated neuropathy
Grant number：16K09693 2016.4 - 2019.3
Iijima Masahiro
Authorship：Coinvestigator(s)
We have conducted a consortium called “CIDP-J” at 16 domestic universities for research of CIDP. More than 200 cases retrospectively and prospectively collected were registered during the research period. Clinical information such as age at onset, sex, progression type, INCAT score, R-ODS, grasp power, MRC score, responsiveness to each therapeutics have been collected. The breakdown of IgG4-subclass autoantibodies (NF155, CNTN1) that target paranode is newly clarified in this study, and it can be useful for future criteria and guideline as well as severity classification.
About NOD B7-2 knockout mice, which are expected as an inflammatory demyelinating model for CIDP, are characterized by progressive posterior weakness with severe infiltration of macrophages as well as lymphocytes in PNS. We analyzed the natural history and fluctuation of the infiltration over time, it leads to the elucidation of pathogenesis reflecting disease activity and irreversible axonal degeneration.
