Updated on 2025/03/24

写真a

 
YAGI, Tetsuya
 
Organization
Graduate School of Medicine Program in Integrated Medicine Development Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 （ 1999.1   名古屋大学 ） 

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Research Interests 2

  1. Infectious Disease Epidemiology

  2. Drug resistant bacteria

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Research Areas 1

  1. Others / Others  / Infectious Diseases

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Current Research Project and SDGs 3

  1. 非結核性抗酸菌症の病態解明

  2. 院内肺炎の臨床的検討

  3. Molecular epidemiology of nosocomial infections

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Education 1

  1. Nagoya University   Faculty of Medicine

    1982.4 - 1988.3

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    Country： Japan

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Professional Memberships 7

  1. 日本内科学会

  2. 日本感染症学会   評議員、中日本地方会理事

    2010.4

  3. Japanese Society of Infection Prevention and Control

    2010.4

  4. 日本臨床微生物学会   評議員、編集委員長、理事

    2010.4

  5. 日本結核病学会   評議員

    2008.4

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Committee Memberships 2

  1. 厚生科学審議会 感染症部会薬剤耐性（ＡＭＲ）に関する小委員会   委員  

    2015   

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    Committee type：Government

  2. 日本病院会   感染対策委員会委員  

    2018.4   

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    Committee type：Other

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Papers 86

  1. Molecular epidemiological analysis and risk factors for acquisition of carbapenemase-producing <i>Enterobacter cloacae</i> complex in a Japanese university hospital

    Tetsuka, N; Hirabayashi, A; Matsumoto, A; Oka, K; Hara, Y; Morioka, H; Iguchi, M; Tomita, Y; Suzuki, M; Shibayama, K; Yagi, T

    ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL   Vol. 8   page： 126   2019.7

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  2. The first multi-centre point-prevalence survey in four Japanese university hospitals

    Morioka H., Nagao M., Yoshihara S., Ohge H., Kasahara K., Shigemoto N., Kajihara T., Mori M., Iguchi M., Tomita Y., Ichiyama S., Yagi T.

    JOURNAL OF HOSPITAL INFECTION   Vol. 99 ( 3 ) page： 325 - 331   2018.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jhin.2018.03.005

    Web of Science

    PubMed

  3. Risk factors for 30-day mortality in patients with pneumonia who receive appropriate initial antibiotics: an observational cohort study Reviewed

    Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, Hasegawa Y; Central Japan Lung Study Group

    Lancet Infectious Diseases   Vol. 15 ( 9 ) page： 1055-65   2015.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  4. Genetic diversity of clinical Mycobacterium avium subsp. hominissuis and Mycobacterium intracellulare isolates causing pulmonary diseases recovered from different geographical regions. Reviewed

    Ichikawa K, van Ingen J, Koh WJ, Wagner D, Salfinger M, Inagaki T, Uchiya K, Nakagawa T, Ogawa K, Yamada K, Yagi T.

    Infection, Genetics and Evolution   Vol. 36 ( - ) page： 250-55   2015.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Mycobacterium avium complex (MAC) infections are increasing annually in many countries. MAC strains are the most common nontuberculous mycobacterial pathogens isolated from respiratory samples and predominantly consist of two species, Mycobacterium avium and Mycobacterium intracellulare. The aim of this study was to analyze the molecular epidemiology and genetic backgrounds of clinical MAC isolates collected from The Netherlands, Germany, United States, Korea and Japan. Variable numbers of tandem repeats (VNTR) analysis was used to examine the genetic relatedness of clinical isolates of M. avium subsp. hominissuis (n=261) and M. intracellulare (n=116). Minimum spanning tree and unweighted pair group method using arithmetic averages analyses based on the VNTR data indicated that M. avium subsp. hominissuis isolates from Japan shared a high degree of genetic relatedness with Korean isolates, but not with isolates from Europe or the United States, whereas M. intracellulare isolates did not show any specific clustering by geographic origin. The findings from the present study indicate that strains of M. avium subsp. hominissuis, but not M. intracellulare, exhibit geographical differences in genetic diversity and imply that MAC strains may have different sources, routes of transmission and perhaps clinical manifestations.

    PubMed

  5. Molecular Epidemiological Characteristics of Klebsiella pneumonia Associated with Bacteremia among Patients with Pneumonia Reviewed

    Ito R, Shindo Y, Kobayashi D, Ando M, Jin W, Wachino JI, Yamada K, Kimura K, Yagi T, Hasegawa Y, Arakawa Y

    Journal of Clinical Microbiology   Vol. 53 ( 3 ) page： 879-886   2015.3

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    Language：English   Publishing type：Research paper (scientific journal)  

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Books 2

  1. 抗菌薬・抗微生物薬の選び方・使い方Ｑ＆Ａ　1. まず押さえておくべき基本中の基本　1) 適切な抗微生物薬治療とは

    八木哲也（ Role： Sole author）

    文光堂  2014.8 

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    Language：Japanese

  2. 感染症診療の基礎と臨床～耐性菌の制御に向けて～

    （ Role： Joint author）

    医薬ジャーナル社  2010.4 

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    Language：Japanese

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. 地域連携に基づいた医療機関等における薬剤耐性菌の感染制御に関する研究

    2016.4 - 2017.3

    科学技術振興調整費 

    八木　哲也

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    Grant type：Competitive

  2. 医療機関における感染制御に関する研究

    2013.4 - 2016.3

    科学技術振興調整費 

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    Grant type：Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. Development of a rapid and easy genotyping method for identification and monitoring transmission events by hypervirulent Klebsiella pneumoniae

    Grant number：20K08819  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kawamura Kumiko

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    Authorship：Coinvestigator(s) 

    We aimed to develop the multiplex PCR typing method for K. pneumoniae that would be useful in hospital epidemiology and outbreak investigation. This typing method consists of two multiplex PCR reactions that were designed to detect 25 ORFs specific to bacterial genetic lineages, species, antimicrobial-resistant genes (blaCTX-M, blaIMP and blaKPC), a capsular K1-specific gene and a virulence factor gene (rmpA/A2). The distribution patterns of ORFs among K. pneumoniae correlated well with multilocus sequence typing, and closely related species could be distinguished and antimicrobial resistance and hypervirulence genes were identified. This typing method is a rapid and easy genotyping method for monitoring transmission events by K. pneumoniae in clinical microbiology laboratories, and supplies clear and informative molecular typing results for the isolates. In addition, this would facilitate molecular epidemiological analysis in infection control and hospital epidemiology investigations.

  2. Molecular epidemiology and resistance mechanism of carbapenem-resistant Enterobacter cloacae

    Grant number：16K09931  2016.4 - 2019.3

    Yagi Tetsuya

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    Authorship：Principal investigator 

    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    Thirty-nine carbapenem-resistant Enterobacter cloacae complex (CRECC) isolates recovered in Nagoya University Hospital from 2012 to 2016. Twenty out of 39 CRECC were carbapenemase-producing (CP) ECC. Molecular epidemiologic analysis with MLST and Rep-PCR showed ST53 (6 strains), ST113 (7 strains), ST513 (2 strains) among CPE strains were genetically closely-related. Whole genome sequencing analysis of plasmids from seven representative CPE strains revealed that they all had similar structure of plasmid with class I integron containing IMP-1 gene and IncHI2A replicon type.
    Eighty-two ECC isolates, which were suspected to produce carbapenemase, were collected from 24 hospitals participated in an regional network in Aichi prefecture from 2014 to 2016. Eighteen out of 82 isolates, which were recovered from 4 hospitals, were shown to be IMP-1 producers. MLST analysis revealed that CPECC isolates with same ST were identified in the specific hospitals, and rarely seen beyond one hospital.

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Industrial property rights 1

  1. クラスC型β−ラクタマーゼ産生菌の簡易検出法

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    Applicant：八木哲也、和知野純一、荒川宜親

    Application no：2003-416165  Date applied：2003

    Country of applicant：Domestic  

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