Updated on 2021/05/20

写真a

 
YAGI, Tetsuya
 
Organization
Graduate School of Medicine Program in Integrated Medicine Development Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 1999.1   名古屋大学 ) 

Research Areas 1

  1. Others / Others  / Infectious Diseases

Current Research Project and SDGs 3

  1. 非結核性抗酸菌症の病態解明

  2. 院内肺炎の臨床的検討

  3. Molecular epidemiology of nosocomial infections

Education 1

  1. Nagoya University   Faculty of Medicine

    1982.4 - 1988.3

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    Country: Japan

Professional Memberships 7

  1. 日本内科学会

  2. 日本感染症学会   評議員、中日本地方会理事

    2010.4

  3. Japanese Society of Infection Prevention and Control

    2010.4

  4. 日本臨床微生物学会   評議員、理事

    2010.4

  5. 日本結核病学会   評議員、学会賞選考委員、用語委員

    2008.4

  6. 日本呼吸器学会

  7. 日本化学療法学会

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Committee Memberships 1

  1. 厚生科学審議会 感染症部会薬剤耐性(AMR)に関する小委員会   委員  

    2015   

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    Committee type:Government

 

Papers 50

  1. Molecular epidemiological analysis and risk factors for acquisition of carbapenemase-producing Enterobacter cloacae complex in a Japanese university hospital

    Tetsuka Nobuyuki, Hirabayashi Aki, Matsumoto Akane, Oka Keisuke, Hara Yuki, Morioka Hiroshi, Iguchi Mitsutaka, Tomita Yuka, Suzuki Masato, Shibayama Keigo, Yagi Tetsuya

    ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL   Vol. 8   page: 126   2019.7

  2. The first multi-centre point-prevalence survey in four Japanese university hospitals

    Morioka H., Nagao M., Yoshihara S., Ohge H., Kasahara K., Shigemoto N., Kajihara T., Mori M., Iguchi M., Tomita Y., Ichiyama S., Yagi T.

    JOURNAL OF HOSPITAL INFECTION   Vol. 99 ( 3 ) page: 325-331   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jhin.2018.03.005

    Web of Science

  3. Risk factors for 30-day mortality in patients with pneumonia who receive appropriate initial antibiotics: an observational cohort study Reviewed

    Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, Hasegawa Y; Central Japan Lung Study Group

    Lancet Infectious Diseases   Vol. 15 ( 9 ) page: 1055-65   2015.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  4. Genetic diversity of clinical Mycobacterium avium subsp. hominissuis and Mycobacterium intracellulare isolates causing pulmonary diseases recovered from different geographical regions. Reviewed

    Ichikawa K, van Ingen J, Koh WJ, Wagner D, Salfinger M, Inagaki T, Uchiya K, Nakagawa T, Ogawa K, Yamada K, Yagi T.

    Infection, Genetics and Evolution   Vol. 36 ( - ) page: 250-55   2015.9

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    Mycobacterium avium complex (MAC) infections are increasing annually in many countries. MAC strains are the most common nontuberculous mycobacterial pathogens isolated from respiratory samples and predominantly consist of two species, Mycobacterium avium and Mycobacterium intracellulare. The aim of this study was to analyze the molecular epidemiology and genetic backgrounds of clinical MAC isolates collected from The Netherlands, Germany, United States, Korea and Japan. Variable numbers of tandem repeats (VNTR) analysis was used to examine the genetic relatedness of clinical isolates of M. avium subsp. hominissuis (n=261) and M. intracellulare (n=116). Minimum spanning tree and unweighted pair group method using arithmetic averages analyses based on the VNTR data indicated that M. avium subsp. hominissuis isolates from Japan shared a high degree of genetic relatedness with Korean isolates, but not with isolates from Europe or the United States, whereas M. intracellulare isolates did not show any specific clustering by geographic origin. The findings from the present study indicate that strains of M. avium subsp. hominissuis, but not M. intracellulare, exhibit geographical differences in genetic diversity and imply that MAC strains may have different sources, routes of transmission and perhaps clinical manifestations.

    PubMed

  5. Molecular Epidemiological Characteristics of Klebsiella pneumonia Associated with Bacteremia among Patients with Pneumonia Reviewed

    Ito R, Shindo Y, Kobayashi D, Ando M, Jin W, Wachino JI, Yamada K, Kimura K, Yagi T, Hasegawa Y, Arakawa Y

    Journal of Clinical Microbiology   Vol. 53 ( 3 ) page: 879-886   2015.3

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  6. Characterization of a Novel Plasmid,pMAH135,from Mycobacterium avium Subsp.hominissuis

    Kei-ichi Uchiya, Hiroyasu Takahashi, Taku Nakagawa, Tetsuya Yagi, Makoto Moriyama, Takayuki Inagaki, Kazuya Ichikawa, Toshiaki Nikai,Kenji Ogawa

    PLOS ONE   Vol. 10 ( 2 ) page: e0117797   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  7. Effect of incubation atmosphere on the production and composition of staphylococcal biofilms

    Asai K, Yamada K, Yagi T, Baba H, Kawamura I, Ohta M

    Journal of Infection and Chemotherapy   Vol. 21 ( 1 ) page: 55-61   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  8. Practical Agar-Based Disk Potentiation Test to Detect Fosfomycin-Non-Susceptible Escherichia coli Clinical Isolates Producing Glutathione S-Transferases

    Nakamura G, Wachino JI, Sato N, Kimura K, Yamada K, Jin W, Shibayama K, Yagi T, Kawamura K, Arakawa Y

    Journal of Clinical Microbiology   Vol. 52 ( 9 ) page: 3175-3179   2014.9

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  9. Streptococcus pneumoniae Invades Erythrocytes and Utilizes Them to Evade Human Innate Immunity. Reviewed

    Yamaguchi M, Terao Y, Mori-Yamaguchi, Domon H, Sakaue Y, Yagi T, Nishino K, Yamaguchi A, Nizet V, Kawabata S

    PLOS ONE   Vol. 8 ( 10 ) page: e77282   2013.10

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  10. Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia

    Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Shiraki A, Goto Y, Fukui Y, Iwaki M, Okamura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindou J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, Hasagawa Y

    American Journal of Respiratory and Critical Care Medicine   Vol. 188 ( 8 ) page: 985-995   2013.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  11. Comparative Genome Analysis of Mycobacterium avium Revealed Genetic Diversity in Strains that Cause Pulmonary and Disseminated Disease Reviewed

    Kei-ichi Uchiya, Hiroyasu Takahashi, Tetsuya Yagi, Makoto Moriyama, Takayuki Inagaki, Kazuya Ichikawa, Taku Nakagawa, Toshiaki Nikai, Kenji Ogawa

    PLOS ONE   Vol. 8 ( 8 ) page: e71831   2013.8

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  12. Cryptococcal cellulitis in a patient with bullous pemphigoid Reviewed

    Sugiura K, Sugiura N, Yagi T, Iguchi M, Ohno H, Miyazaki Y and Akiyama M

    Acta Derm Venereol   Vol. 93 ( 2 ) page: 187-188   2013.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  13. Antitubercular Activity of Disulfiram, an Antialcoholism Drug, against Multidrug-and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates Reviewed

    4) Horita Y, Takii T, Yagi T, Ogawa K, Fujiwara N, Inagaki E, Kremer L, Sato Y, Kuroishi R, Lee Y, Makino T, Mizukami H, Hasegawa T, Yamamoto R, and Onozaki K

    Antimicrobial Agents and Chemotherapy   Vol. 56 ( 8 ) page: 4140-4145   2012.8

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  14. Molecular Typing of Mycobacterium intracellulare using Multilocus Variable-Number of Tandem-Repeat Analysis: Identification of Loci and Analysis of Clinical Isolates. Reviewed

    Ichikawa K, Yagi T, Inagaki T, Moriyama M, Nakagawa T, Uchiya KI, Nikai T, Ogawa K

    Micrbiology   Vol. 156 ( 2 ) page: 496-504   2010.2

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  15. *Usefulness of Phage Open-Reading Frame Typing Method in an Epidemiological Study of an Outbreak of Methicillin-Resistant Staphylococcus aureus Infections. Reviewed

    Nada T, Yagi T, Ohkura T, Morishita Y, Baba H, Ohta M, Suzuki M

    Japanese Journal of Infectious Diseases   Vol. 62 ( 5 ) page: 386-389   2009.5

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  16. *Screening for methicillin-resistant Staphylococcus aureus (MRSA) carriage on admission to a geriatric hospital. Reviewed

    Nishikawa M, Tanaka T, Nakashima K, Senda K, Shibasaki M, Miura H, Tamakoshi A, Ohta T, Yagi T

    Archives Gerontology and Geriatrics   Vol. 49 ( 2 ) page: 242-245   2009

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  17. *Characterization of Mycobacterium avium clinical isolates in Japan using subspecies-specific insertion sequences, and identification of a new insertion sequence, ISMav6. Reviewed

    Ichikawa K, Yagi T, Moriyama M, Inagaki T, Nakagawa T, Uchiya KI, Nikai T, Ogawa K

    Journal of Medical Microbiology   Vol. 58 ( 7 ) page: 945-950   2009.7

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  18. Evaluation of a rapid detection method of clarithromycin-resistance genes in Mycobacterium avium complex isolates Reviewed

    Inagaki T, Yagi T, Ichikawa K, Nakagawa T, Moriyama M, Uchiya K, Nikai T, Ogawa K

    Journal of Antimicrobial Chemotherapy   Vol. 66 ( 4 ) page: 722-729   2011.4

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  19. *Polymerization of Mycobacterial Arabinogalactan and Ligation to Peptidoglycan Reviewed

    Yagi T, Mahapatra S, Mikusova K, Crick DC, and Brennan PJ

    Journal of Biological Chemistry   Vol. 278   page: 26497-26504   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  20. *Practical Methods for Identification of Class C β-Lactamase-Producing Klebsiella pneumoniae and Escherichia coli Using Boronic Acid Compounds Reviewed

    Yagi, T, Wachino, J, Kurokawa, H, Yamane, K, Doi, Y, Shibata, N, Kato, H, Shibayama, K, and Arakawa, Y

    Journal of Clinical Microbiology   Vol. 43 ( 6 ) page: 2551-2558   2005.6

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  21. A Case Report of Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. massiliense.

    Oka K, Morioka H, Eguchi M, Sato Y, Tetsuka N, Iguchi M, Kanematsu T, Fukano H, Hoshino Y, Kiyoi H, Yagi T

    Internal medicine (Tokyo, Japan)     2021.3

  22. Efficacy of favipiravir for an end stage renal disease patient on maintenance hemodialysis infected with novel coronavirus disease 2019

    Koshi Eri, Saito Shoji, Okazaki Masaki, Toyama Yuki, Ishimoto Takuji, Kosugi Tomoki, Hiraiwa Hiroaki, Jingushi Naruhiro, Yamamoto Takanori, Ozaki Masayuki, Goto Yukari, Numaguchi Atsushi, Miyagawa Yasuhiro, Kato Io, Tetsuka Nobuyuki, Yagi Tetsuya, Maruyama Shoichi

    CEN CASE REPORTS   Vol. 10 ( 1 ) page: 126 - 131   2021.2

  23. Trends of the Use of Anti-methicillin-Resistant Staphylococcus aureus Agents in Japan Based on Sales Data from 2006 to 2015

    Goto Ryota, Inose Ryo, Kusama Yoshiki, Kawabe Ayako, Ishii Saki, Ebisui Ai, Ishikane Masahiro, Yagi Tetsuya, Ohmagari Norio, Muraki Yuichi

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 43 ( 12 ) page: 1906 - 1910   2020.12

  24. Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days

    Sato Yoshitaka, Iguchi Mitsutaka, Kato Yoshiaki, Morioka Hiroshi, Hirabayashi Aki, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yamada Kiyofumi, Kimura Hiroshi, Yagi Tetsuya

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page: 407 - 414   2020.8

  25. Impact of antimicrobial stewardship fee on prescribing for Japanese pediatric patients with upper respiratory infections

    Muraki Yuichi, Kusama Yoshiki, Tanabe Masaki, Hayakawa Kayoko, Gu Yoshiaki, Ishikane Masahiro, Yamasaki Daisuke, Yagi Tetsuya, Ohmagari Norio

    BMC HEALTH SERVICES RESEARCH   Vol. 20 ( 1 ) page: 399   2020.5

  26. The Trend for Antibiotic Use for Clostridioides (Clostridium) difficile Infection in Japan

    Ishii Saki, Muraki Yuichi, Kusama Yoshiki, Yagi Tetsuya, Goto Ryota, Ebisui Ai, Kawabe Ayako, Inose Ryo, Ohmagari Norio

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 43 ( 4 ) page: 693 - 696   2020.4

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  27. Detection of bacteria in blood circulation in patients receiving cancer chemotherapy

    Ota Akiko, Morita Sachi, Matsuoka Ayumu, Shimokata Tomoya, Maeda Osamu, Mitsuma Ayako, Yagi Tetsuya, Asahara Takashi, Ando Yuichi

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 210 - 215   2020.1

  28. The Trend for Antibiotic Use for Clostridioides (Clostridium) difficile Infection in Japan.

    Ishii S, Muraki Y, Kusama Y, Yagi T, Goto R, Ebisui A, Kawabe A, Inose R, Ohmagari N

    Biological & pharmaceutical bulletin   Vol. 43 ( 4 ) page: 693 - 696   2020

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  29. Automated detection of outbreaks of antimicrobial-resistant bacteria in Japan.

    Tsutsui A, Yahara K, Clark A, Fujimoto K, Kawakami S, Chikumi H, Iguchi M, Yagi T, Baker MA, O'Brien T, Stelling J

    The Journal of hospital infection   Vol. 102 ( 2 ) page: 226 - 233   2019.6

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    DOI: 10.1016/j.jhin.2018.10.005

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    PubMed

  30. Fungal endocarditis after transcatheter aortic valve replacement (TAVR): Case report and review of literature

    Morioka Hiroshi, Tokuda Yoshiyuki, Oshima Hideki, Iguchi Mitsutaka, Tomita Yuka, Usui Akihiko, Yagi Tetsuya

    JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 25 ( 3 ) page: 215 - 217   2019.3

  31. A New Scoring System for Predicting Adverse Events in Hospitalized Patients with Community-Onset Pneumonia

    Sakakibara T., Shindo Y., Takahashi K., Kobayashi D., Okumura J., Sano M., Murakami Y., Thabet N., Kobayashi H., Yagi T., Matsui S., Saka H., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 199   2019

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  32. [Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient].

    Harada Y, Murata M, Matsumoto A, Kato D, Yagi T, Yaguchi T, Yoshikawa T, Takeichi T, Akiyama M, Yamaguchi Y, Koyama D, Terakura S, Nishida T, Kiyoi H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 60 ( 12 ) page: 1641 - 1646   2019

  33. Severe and Prolonged Lymphopenia Are Associated with Poor Outcome in Patients with Postoperative Pneumonia

    Murakami Y., Shindo Y., Sano M., Okumura J., Sakakibara T., Kobayashi H., Thabet N., Yagi T., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 199   2019

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  34. Active surveillance in response to the identification of a single carbapenemase-producing Escherichia coli at a Japanese university hospital.

    Kato D, Morioka H, Tomita Y, Iguchi M, Hirabayashi A, Tetsuka N, Sadomoto T, Hyodo M, Mochizuki M, Osada Y, Yamamoto M, Kato Y, Inagaki T, Ichikawa K, Yagi T

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   Vol. 24 ( 12 ) page: 1013 - 1015   2018.12

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    DOI: 10.1016/j.jiac.2018.05.013

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  35. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of -lactam plus macrolide combination therapy

    Okumura Junya, Shindo Yuichiro, Takahashi Kunihiko, Sano Masahiro, Sugino Yasuteru, Yagi Tetsuya, Taniguchi Hiroyuki, Saka Hideo, Matsui Shigeyuki, Hasegawa Yoshinori

    RESPIROLOGY   Vol. 23 ( 5 ) page: 526 - 534   2018.5

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    DOI: 10.1111/resp.13232

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  36. Preoperative biliary colonization/infection caused by multidrug-resistant (MDR) pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection

    Sugawara Gen, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Yamaguchi Junpei, Mizuno Takashi, Yagi Tetsuya, Nagino Masato

    SURGERY   Vol. 163 ( 5 ) page: 1106 - 1113   2018.5

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    DOI: 10.1016/j.surg.2017.12.031

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  37. The first report of Japanese antimicrobial use measured by national database based on health insurance claims data (2011-2013): comparison with sales data, and trend analysis stratified by antimicrobial category and age group

    Yamasaki Daisuke, Tanabe Masaki, Muraki Yuichi, Kato Genta, Ohmagari Norio, Yagi Tetsuya

    INFECTION   Vol. 46 ( 2 ) page: 207 - 214   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s15010-017-1097-x

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  38. Evaluation of treatment outcomes of patients with MRSA bacteremia following antimicrobial stewardship programs with pharmacist intervention

    Ohashi Kengo, Matsuoka Tomoko, Shinoda Yasutaka, Fukami Yasuyuki, Shindoh Joe, Yagi Tetsuya, Yoshimura Tomoaki, Sugiyama Tadashi

    INTERNATIONAL JOURNAL OF CLINICAL PRACTICE   Vol. 72 ( 3 ) page: e13065   2018.3

  39. Comprehensive detection of pathogens in immunocompromised children with bloodstream infections by next-generation sequencing

    Horiba Kazuhiro, Kawada Jun-ichi, Okuno Yusuke, Tetsuka Nobuyuki, Suzuki Takako, Ando Shotaro, Kamiya Yasuko, Torii Yuka, Yagi Tetsuya, Takahashi Yoshiyuki, Ito Yoshinori

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 3784   2018.2

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    DOI: 10.1038/s41598-018-22133-y

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  40. Duration of Antimicrobial Prophylaxis in Patients Undergoing Major Hepatectomy With Extrahepatic Bile Duct Resection: A Randomized Controlled Trial

    Sugawara Gen, Yokoyama Yukihiro, Ebata Tomoki, Mizuno Takashi, Yagi Tetsuya, Ando Masahiko, Nagino Masato

    ANNALS OF SURGERY   Vol. 267 ( 1 ) page: 142 - 148   2018.1

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    DOI: 10.1097/SLA.0000000000002049

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  41. Validation of the prediction rules identifying drug-resistant pathogens in community-onset pneumonia

    Kobayashi Daisuke, Shindo Yuichiro, Ito Ryota, Iwaki Mai, Okumura Junya, Sakakibara Toshihiro, Yamaguchi Ikuo, Yagi Tetsuya, Ogasawara Tomohiko, Sugino Yasuteru, Taniguchi Hiroyuki, Saito Hiroshi, Saka Hideo, Kawamura Takashi, Hasegawa Yoshinori

    INFECTION AND DRUG RESISTANCE   Vol. 11   page: 1703 - 1713   2018

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    DOI: 10.2147/IDR.S165669

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  42. Appropriateness of surgical prophylaxis contributed to significant reduction of oral cephalosporins in a Japanese university hospital

    Morioka Hiroshi, Kato Yoshiaki, Inagaki Takayuki, Tetsuka Nobuyuki, Iguchi Mitsutaka, Tomita Yuka, Yagi Tetsuya

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 50   page: S42-S43   2017.11

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  43. Risk factors for and role of OprD protein in increasing minimal inhibitory concentrations of carbapenems in clinical isolates of Pseudomonas aeruginosa

    Hirabayashi Aki, Kato Daizo, Tomita Yuka, Iguchi Mitsutaka, Yamada Keiko, Kouyama Yuichi, Morioka Hiroshi, Tetsuka Nobuyuki, Yagi Tetsuya

    JOURNAL OF MEDICAL MICROBIOLOGY   Vol. 66 ( 11 ) page: 1562 - 1572   2017.11

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    DOI: 10.1099/jmm.0.000601

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  44. Recurrent bacteremia and liver abscess caused by Clostridium difficile A case report

    Morioka Hiroshi, Iguchi Mitsutaka, Kuzuya Teiji, Mikamo Hiroshige, Yagi Tetsuya

    MEDICINE   Vol. 96 ( 35 ) page: e7969   2017.9

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    DOI: 10.1097/MD.0000000000007969

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  45. Collaboration with an infection control team for patients with infection after spine surgery

    Kobayashi Kazuyoshi, Imagama Shiro, Kato Daizo, Ando Kei, Hida Tetsuro, Ito Kenyu, Tsushima Mikito, Matsumoto Akiyuki, Morozumi Masayoshi, Tanaka Satoshi, Yagi Tetsuya, Nishida Yoshihiro, Ishiguro Naoki

    AMERICAN JOURNAL OF INFECTION CONTROL   Vol. 45 ( 7 ) page: 767 - 770   2017.7

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    DOI: 10.1016/j.ajic.2017.01.013

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  46. Pneumococcal biliary tract infections - How rare are they?

    Morioka Hiroshi, Iguchi Mitsutaka, Oodate Mitsuru, Yoneda Masaki, Ushijima Futoshi, Hirabayashi Aid, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yagi Tetsuya

    JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 23 ( 5-6 ) page: 415 - 418   2017

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    DOI: 10.1016/j.jiac.2016.11.008

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  47. Risk Factors For Severe Adverse Outcomes In Patients With Hospital-Acquired Pneumonia

    Sano M., Shindo Y., Okumura J., Sakakibara T., Matsuda T., Yagi T., Matsui K., Takahashi K., Matsui S., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 195   page: .   2017

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  48. The first point prevalence survey of health care-associated infection and antimicrobial use in a Japanese university hospital: A pilot study. Reviewed

    Morioka H, Hirabayashi A, Iguchi M, Tomita Y, Kato D, Sato N, Hyodo M, Kawamura N, Sadomoto T, Ichikawa K, Inagaki T, Kato Y, Kouyama Y, Ito Y, Yagi T.

    American journal of infection control   Vol. 44 ( 7 ) page: e119-e123   2016.6

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    BACKGROUND:

    Point prevalence surveys (PPSs) in Japanese hospitals have not yet been reported. The purpose of this pilot PPS study was to evaluate the epidemiology of health care-associated infections (HAIs) and antimicrobial use in a Japanese tertiary university hospital.

    METHODS:

    A 1-day, cross-sectional PPS was performed at a Japanese university hospital. Data on demographics, active HAIs, and antimicrobial use of all inpatients were collected using a data collection form.

    RESULTS:

    Of 841 patients, 85 (10.1%) had 90 active HAIs, and 308 patients (36.6%) were administered 494 antimicrobials. Among the 90 HAIs and 58 pathogens, the most frequent infection and isolated pathogen were pneumonia (20.0%) and Enterobacteriaceae (27.6%), respectively. Of the 118 antimicrobials used for treatment of HAIs, carbapenems were the most frequently administered category of antimicrobials (22.9%). In regard to antimicrobials for surgical prophylaxis, 37 of 119 (31.1%) were administered to patients on postoperative day 3 or later, and 48 of 119 (40.3%) were administered orally.

    CONCLUSIONS:

    The incidence of HAIs is higher than in other developed countries. The social and medical situation in Japan may affect patient demographics, active HAIs, and antimicrobial use. Multicenter PPSs are necessary to uncover the real epidemiology of HAIs and antimicrobial use in Japan.

    PubMed

  49. Massive mediastinal cryptococcosis in a young immunocompetent patient. Reviewed

    Okachi S, Wakahara K, Kato D, Umeyama T, Yagi T, Hasegawa Y.

    Respirology Case Reports   Vol. 3 ( 3 ) page: 95-98   2015.9

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  50. Molecular and clinical characterization of plasmid-mediated AmpC β-lactamase-producing Escherichia coli bacteraemia: a comparison with extended-spectrum β-lactamase-producing and non-resistant E. coli bacteraemia. Reviewed

    Matsumura Y, Nagao M, Iguchi M, Yagi T, Komori T, Fujita N, Yamamoto M, Matsushima A, Takakura S, Ichiyama S

    Clincal Microbiology Infection   Vol. 19 ( 2 ) page: 161-168   2013.2

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Books 2

  1. 抗菌薬・抗微生物薬の選び方・使い方Q&A 1. まず押さえておくべき基本中の基本 1) 適切な抗微生物薬治療とは

    八木哲也( Role: Sole author)

    文光堂  2014.8 

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    Language:Japanese

  2. 感染症診療の基礎と臨床~耐性菌の制御に向けて~

    ( Role: Joint author)

    医薬ジャーナル社  2010.4 

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    Language:Japanese

Research Project for Joint Research, Competitive Funding, etc. 2

  1. 地域連携に基づいた医療機関等における薬剤耐性菌の感染制御に関する研究

    2016.4 - 2017.3

    科学技術振興調整費 

    八木 哲也

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    Grant type:Competitive

  2. 医療機関における感染制御に関する研究

    2013.4 - 2016.3

    科学技術振興調整費 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. 感染症診断と感染制御支援のための新規高病原性肺炎桿菌解析法の構築とその臨床的評価

    Grant number:20K08819  2020.4 - 2023.3

    川村 久美子

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    Authorship:Coinvestigator(s) 

    高病原性肺炎桿菌(hvKp)の出現と増加、さらにはカルバペネマーゼを産生するhvKp株(CPE-hvKp)の出現も報告され、肺炎桿菌感染症の現状は深刻になりつつある。hvKpおよびCPE-hvKp感染症は市中および医療環境の両方でみられることから、本感染症の診断と感染制御の両方に貢献できる分子疫学解析法が必要である。
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    本研究では、CPEの世界的流行クローンや病原性と関連するシークエンスタイプの特定、hvKp株に特異的な病原遺伝子群の保有や莢膜型別ならびにカルバペネマーゼ産生遺伝子の保有をOne-stepで検出する "multiplex PCR typing method" を構築する。

  2. Molecular epidemiology and resistance mechanism of carbapenem-resistant Enterobacter cloacae

    Grant number:16K09931  2016.4 - 2019.3

    Yagi Tetsuya

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    Authorship:Principal investigator 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    Thirty-nine carbapenem-resistant Enterobacter cloacae complex (CRECC) isolates recovered in Nagoya University Hospital from 2012 to 2016. Twenty out of 39 CRECC were carbapenemase-producing (CP) ECC. Molecular epidemiologic analysis with MLST and Rep-PCR showed ST53 (6 strains), ST113 (7 strains), ST513 (2 strains) among CPE strains were genetically closely-related. Whole genome sequencing analysis of plasmids from seven representative CPE strains revealed that they all had similar structure of plasmid with class I integron containing IMP-1 gene and IncHI2A replicon type.
    Eighty-two ECC isolates, which were suspected to produce carbapenemase, were collected from 24 hospitals participated in an regional network in Aichi prefecture from 2014 to 2016. Eighteen out of 82 isolates, which were recovered from 4 hospitals, were shown to be IMP-1 producers. MLST analysis revealed that CPECC isolates with same ST were identified in the specific hospitals, and rarely seen beyond one hospital.

Industrial property rights 1

  1. クラスC型β−ラクタマーゼ産生菌の簡易検出法

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    Applicant:八木哲也、和知野純一、荒川宜親

    Application no:2003-416165  Date applied:2003

    Country of applicant:Domestic