Updated on 2021/03/22

写真a

 
GOTO, Maki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Medicine in Growth and Aging Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor
Contact information
メールアドレス
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Degree 1

  1. 医学博士 ( 2007.10   名古屋大学 ) 

Research Interests 1

  1. 不妊 生殖 卵胞発育 顆粒膜細胞 

Research Areas 1

  1. Others / Others  / Obstetrics and Gynecology

Research History 4

  1. 名古屋大学医学部附属病院    産婦人科   病院講師

    2013.4

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    Country:Japan

  2. 名古屋大学医学部附属病院周産母子センター 助教

    2011.4 - 2013.3

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    Country:Japan

  3. 大学院医学系研究科助教

    2009.4

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    Country:Japan

  4. 医学部附属病院助手

    2007.9

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2003.4 - 2007.3

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    Country: Japan

  2. Nippon Medical School   Faculty of Medicine

    1991.4 - 1997.3

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    Country: Japan

Professional Memberships 7

  1. Japan Society of Obstetrics And Gynecology

  2. Japan Society for Reproductive Medicine

  3. Japan Society od Fertilization and Implantation

  4. The Japan Society of Human Genetics

  5. Japan Society for Infertility Counseling

  6. Japan Society of Gynecologic and Obstetric Endoscopy

  7. The Japan Society for Oriental Medicine

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Papers 48

  1. *PTEN and Akt expression during growth of human ovarian follicles Reviewed

    Goto M, Iwase A, Ando H, Kurotsuchi S, Harata T, Kikkawa F

    J Assist Reprod Genet   Vol. 24 ( 11 ) page: 541-546   2007.11

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    PURPOSE: To assess the expression of PTEN and total and phosphorylated Akt in human ovarian follicles during follicular growth. METHODS: Immunohistochemistry of ovarian tissues and Western blotting and immunofluorescence of primary cultured luteinized granulosa cells for PTEN and Akt. RESULTS: Immunoreactivity of Akt was found in the oocytes, granulosa cells and theca cells in primordial follicles, follicles at each growing stage and luteal cells. As the follicles grew, staining for PTEN became intense in the granulosa cells, whereas the intensity of phospho-Akt became weak. Western blotting and immunofluorescence analysis using primary cultured granulosa-lutein cells showed Akt and PTEN expression, and phosphorylation of Akt in vitro. CONCLUSIONS: PTEN and Akt are present in the granulosa cells during folliculogenesis. An increase in PTEN may lead to changes in proliferation and/or differentiation of granulosa cells during follicular growth via regulation of Akt phosphorylation.

  2. *IGF1-induced AKT phosphorylation and cell proliferation are suppressed with the increase in PTEN during luteinization in human granulosa cells. Reviewed

      Vol. 137 ( 5 ) page: 835-842   2009.2

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    Granulosa cells proliferate and then undergo differentiation; an inverse relationship between these processes is observed during terminal follicular growth. During terminal follicular growth and initial luteinization, there is a necessary transition of granulosa cells to a less proliferative and highly steroidogenic form in response to LH. Although the expression of several molecules has been reported to be up-regulated by LH, proliferation/differentiation transition is not fully understood. Here, we show that the expression of a tumor suppressor, phosphatase and tensin homologue deleted on chromosome 10 (PTEN) was induced with human chorionic gonadotropin (hCG) treatment in human luteinized granulosa cells. Pretreatment with hCG attenuated insulin-like growth factor (IGF)-1-induced phosphorylation of AKT and cell proliferation, not phosphorylation of ERK1/2. Moreover, suppression of hCG-induced PTEN expression with siRNA increased AKT phosphorylation and cell proliferation in response to IGF1. We also demonstrate that a PI3K inhibitor, LY294002, not a MEK inhibitor, PD98059, inhibited IGF1-induced cell proliferation. In conclusion, PTEN induced to express by hCG in luteinized granulosa cells that inactivates AKT, not ERK, and attenuates IGF1-induced cell proliferation. PTEN expression may be a trigger for proliferation/differentiation transition in human granulosa cells.

  3. Psychological stress during in vitro fertilization and embryo transfer is influenced by the patients' background and gender Reviewed

    T. Harata, M. Goto, A. Iwase, S. Kurotsuchi, H. Ando, M. Osawa, A. Sugita, M. Kondo, T. Nakamura, T. Nakahara, S. Takikawa, S. Manabe, F. Kikkawa

      Vol. 11 ( 3 ) page: 143-148   2012.7

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  4. 体外受精-胚移植における禁煙指導の影響に関する検討 Reviewed

    後藤真紀, 岩瀬明, 中村智子, 廣川和加奈, 中原辰夫, 小林浩治, 滝川幸子, 眞鍋修一, 永友良成, 黒土升蔵, 原田統子, 吉川史隆

    日本受精着床学会雑誌   Vol. 28 ( 1 ) page: 243-247   2011.2

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  5. Focal Adhesion Kinase-Mediated Sequences, Including Cell Adhesion, Inflammatory Response, and Fibrosis, as a Therapeutic Target in Endometriosis

    Nagai Takashi, Ishida Chiharu, Nakamura Tomoko, Iwase Akira, Mori Masahiko, Murase Tomohiko, Bayasula, Osuka Satoko, Takikawa Sachiko, Goto Maki, Kotani Tomomi, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( 7 ) page: 1400 - 1410   2020.7

  6. Discovery and Quantification of Novel Markers of Primary Ovarian Insufficiency.

    Osuka Satoko, Kasahara Yukiyo, Takasaki Nobuyoshi, Sula Baya, Yoshita Sayako, Nakanishi Natsuki, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 358A - 358A   2020.3

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  7. Primary Follicles Suppress the Growth of Primordial Follicles.

    Wei Wei, Komatsu Kouji, Murase Tomohiko, Sonehara Reina, Miyake Natsuki, Murakami Mayuko, Ganieva Umida, Bayasula Bayasula, Yoshita Sayako, Muraoka Ayako, Hayashi Shotaro, Nakanishi Natsuki, Kasahara Yukiyo, Takasaki Nobuyoshi, Nakamura Tomoko, Osuka Satoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 283A - 283A   2020.3

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  8. Expressions and Effects of Phoenixin and Its Receptor GPR173 During the Human Menstrual Cycle.

    Xuan Phuoc Nguyen, Nakamura Tomoko, Osuka Satoko, Bayasula Bayasula, Muraoka Ayako, Hayashi Shotaro, Nakanishi Natsuki, Kasahara Yukiyo, Murase Tomohiko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 281A - 281A   2020.3

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  9. Exogenous Anti-AMHRII Antibody Treatment Induces Follicular Development in Sliced Ovarian Tissue Cultures.

    Murase Tomohiko, Komatsu Kouji, Wei Wei, Sonehara Reina, Miyake Natsuki, Murakami Mayuko, Umida Ganieva, Bayasula Bayasula, Yoshita Sayako, Muraoka Ayako, Hayashi Shotaro, Nakanishi Natsuki, Kasahara Yukiyo, Nguyen Phuoc X., Takasaki Nobuyoshi, Nakamura Tomoko, Osuka Satoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 367A - 367A   2020.3

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  10. Effect of Unkeito, a Traditional Herbal Medicine, on a Rat Model of Polycystic Ovary Syndrome.

    Yoshita Sayako, Osuka Satoko, Sonehara Reina, Miyake Natsuki, Murakami Mayuko, Wei Wei, Hayashi Shotaro, Muraoka Ayako, Ganieva Umida, Nakanishi Natsuki, Kasahara Yukiyo, Bayasula Bayasula, Takasaki Nobuyoshi, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 191A - 192A   2020.3

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  11. Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis

    Ganieva Umida, Nakamura Tomoko, Osuka Satoko, Bayasula, Nakanishi Natsuki, Kasahara Yukiyo, Takasaki Nobuyoshi, Muraoka Ayako, Hayashi Shotaro, Nagai Takashi, Murase Tomohiko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    AMERICAN JOURNAL OF PATHOLOGY   Vol. 190 ( 1 ) page: 145 - 157   2020.1

  12. Effect of the neuropeptide phoenixin and its receptor GPR173 during folliculogenesis

    Xuan Phuoc Nguyen, Nakamura Tomoko, Osuka Satoko, Bayasula Bayasula, Nakanishi Natsuki, Kasahara Yukiyo, Muraoka Ayako, Hayashi Shotaro, Nagai Takashi, Murase Tomohiko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    REPRODUCTION   Vol. 158 ( 1 ) page: 25 - 34   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1530/REP-19-0025

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  13. Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells

    Shimizu Ken, Nakamura Tomoko, Bayasula, Nakanishi Natsuki, Kasahara Yukiyo, Nagai Takashi, Murase Tomohiko, Osuka Satoko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS   Vol. 36 ( 6 ) page: 1185 - 1194   2019.6

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    DOI: 10.1007/s10815-019-01469-y

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  14. Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides.

    Osuka S, Nakanishi N, Murase T, Nakamura T, Goto M, Iwase A, Kikkawa F

    Reproductive medicine and biology   Vol. 18 ( 2 ) page: 151 - 160   2019.4

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    DOI: 10.1002/rmb2.12262

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  15. Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice

    Qin Ying, Iwase Akira, Murase Tomohiko, Bayasula, Ishida Chiharu, Kato Nao, Nakamura Tomoko, Osuka Satoko, Takikawa Sachiko, Goto Maki, Kotani Tomomi, Kikkawa Fumitaka

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 16 ( 1 ) page: 106   2018.10

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    DOI: 10.1186/s12958-018-0426-y

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  16. TCF21 REGULATION OF PERIOSTIN IN THE PROGRESSION OF ENDOMETRIOTIC FIBROSIS.

    Ganieva U., Nakamura T., Nguyen P. X., Wei W., Murakami M., Miyake N., Nakanishi N., Kasahara Y., Takasaki N., Muraoka A., Hayashi S., Nagai T., Murase T., Osuka S., Goto M., Iwase A.

    FERTILITY AND STERILITY   Vol. 110 ( 4 ) page: E393-E393   2018.9

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  17. Neuropeptide phoenixin (PNX) and its novel receptor GPR173 induce COX-1/COX-2 expression and PGE2 production through the CREB signaling pathway

    Nguyen X. P., Iwase A., Murase T., Ganieva U., Qin Y., Bayasula B., Shimizu K., Osuka S., Nakamura T., Goto M., Kikkawa F.

    HUMAN REPRODUCTION   Vol. 33   page: 287-287   2018.7

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  18. Thyroid Autoantibodies do not Impair the Ovarian Reserve in Euthyroid Infertile Women: A Cross-Sectional Study

    Osuka Satoko, Iwase Akira, Goto Maki, Takikawa Sachiko, Nakamura Tomoko, Murase Tomohiko, Kato Nao, Bayasula, Kotani Tomomi, Kikkawa Fumitaka

    HORMONE AND METABOLIC RESEARCH   Vol. 50 ( 7 ) page: 537 - 542   2018.7

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    DOI: 10.1055/a-0637-9430

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  19. Clinical application of serum anti-Mullerian hormone as an ovarian reserve marker: A review of recent studies

    Iwase Akira, Osuka Satoko, Goto Maki, Murase Tomohiko, Nakamura Tomoko, Takikawa Sachiko, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 44 ( 6 ) page: 998 - 1006   2018.6

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    DOI: 10.1111/jog.13633

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  20. Exogenous GDF-9 Treatment Induces Follicular Development through Downregulation of Anti-Mullerian Hormone Receptor as Visualized in the Sliced Ovarian Tissue Culture System.

    Murase Tomohiko, Iwase Akira, Komatsu Kouji, Wei Wei, Ganieva Umida, Bayasula Bayasula, Nguyen Phuoc X., Yoshita Sayako, Qin Ying, Muraoka Ayako, Hayashi Shotaro, Kasahara Yukiyo, Nakanishi Natsuki, Nagai Takashi, Shimizu Ken, Ishida Chiharu, Nakamura Tomoko, Osuka Satoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 25   page: 177A-177A   2018.3

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  21. Directive Action of Neuropeptide Phoenixin and Its Receptor GPR173 during Folliculogenesis.

    Nguyen Phuoc X., Iwase Akira, Murase Tomohiko, Ganieva Umida, Qin Ying, Bayasula Bayasula, Shimizu Ken, Osuka Satoko, Nakamura Tomoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 25   page: 321A-322A   2018.3

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  22. Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture

    Murase Tomohiko, Iwase Akira, Komatsu Kouji, Bayasula, Nakamura Tomoko, Osuka Satoko, Takikawa Sachiko, Goto Maki, Kotani Tomomi, Kikkawa Fumitaka

    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS   Vol. 35 ( 2 ) page: 339 - 343   2018.2

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    DOI: 10.1007/s10815-017-1073-5

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  23. Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture. Reviewed

    Murase T, Iwase A, Komatsu K, Bayasula, Nakamura T, Osuka S, Takikawa S, Goto M, Kotani T, Kikkawa F.

    J Assist Reprod Genet.     2017.10

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    DOI: 10.1007/s10815-017-1073-5.

  24. Retrospective analysis of magnetic resonance imaging for differentiating intraligamentous leiomyomas from subserosal leiomyomas

    Shimizu Ken, Iwase Akira, Sakurai Yusuke, Nakamura Tomoko, Osuka Satoko, Takikawa Sachiko, Goto Maki, Kikkawa Fumitaka

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 215   page: 256 - 257   2017.8

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    DOI: 10.1016/j.ejogrb.2017.06.046

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  25. Analysis of Follicular Growth and Oocyte Maturation in Cultured Murine Ovarian Tissue.

    Murase Tomohiko, Iwase Akira, Nguyen Phuoc Xuan, Ganieva Umida, Qin Ying, Nakanishi Natsuki, Kasahara Yukiyo, Nagai Takashi, Shimizu Ken, Ishida Chiharu, Kato Nao, Osuka Satoko, Nakamura Tomoko, Takikawa Sachiko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 24   page: 292A-292A   2017.3

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  26. Growth Differentiation Factor 9 Induces Granulosa Cell Proliferation via Inhibition of the Expression of AMH Type II Receptor.

    Iwase Akira, Osuka Satoko, Bayasula Bayasula, Takikawa Sachiko, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 24   page: 163A-163A   2017.3

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  27. Kisspeptin in the Hypothalamus of 2 Rat Models of Polycystic Ovary Syndrome

    Osuka Satoko, Iwase Akira, Nakahara Tatsuo, Kondo Mika, Saito Ai, Bayasula, Nakamura Tomoko, Takikawa Sachiko, Goto Maki, Kotani Tomomi, Kikkawa Fumitaka

    ENDOCRINOLOGY   Vol. 158 ( 2 ) page: 367 - 377   2017.2

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    DOI: 10.1210/en.2016-1333

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  28. A proteomic analysis of human follicular fluid: comparison between fertilized oocytes and non-fertilized oocytes in the same patient. Reviewed

    Bayasula, Iwase A, Kobayashi H, Goto M, Nakahara T, Nakamura T, Kondo M, Nagatomo Y, Kotani T, Kikkawa F.

    J Assist Reprod Genet.   Vol. 30 ( 9 ) page: 1231-8   2013.7

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    DOI: 10.1007/s10815-013-0004-3

  29. Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status. Reviewed

    Bayasula, Iwase A, Kiyono T, Takikawa S, Goto M, Nakamura T, Nagatomo Y, Nakahara T, Kotani T, Kobayashi H, Kondo M, Manabe S, Kikkawa F.

    Endocrinology   Vol. 153 ( 6 ) page: 2851-60   2012.10

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  30. Sphingosine-1-phosphate inhibits H(2)O(2)-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. Reviewed

    Nakahara T, Iwase A, Nakamura T, Kondo M, Bayasula, Kobayashi H, Takikawa S, Manabe S, Goto M, Kotani T, Kikkawa F.

    Fertility and Sterility   Vol. 98 ( 4 ) page: 1001-1008   2012.10

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  31. Successful surgical management of a septate uterus constricted with leiomyomas: hysteroscopic metroplasty using a Foley catheter. Reviewed

    Iwase A, Goto M, Manabe S, Kobayashi H, Kondo M, Kikkawa F.

    Archives of gynecology and obstetrics     page: 1   2012.9

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  32. Expression and localization of CXCL16 and CXCR6 in ovarian endometriotic tissues. Reviewed

    Manabe S, Iwase A, Goto M, Kobayashi H, Takikawa S, Nagatomo Y, Nakahara T, Bayasula, Nakamura T, Hirokawa W, Kikkawa F.

    Arch Gynecol Obstet.   Vol. 284 ( 6 ) page: 1567-1572   2011.12

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  33. 子宮内膜症の成因に関する基礎的研究 プロゲステロン依存性CD10発現の変化がCD44依存性細胞接着に影響を及ぼす Reviewed

    岩瀬 明, 永友 良成, 巴雅蘇拉 , 中村 智子, 廣川 和加奈, 中原 辰夫, 滝川 幸子, 小林 浩治, 真鍋 修一, 後藤 真紀, 吉川 史隆

    日本エンドメトリオーシス学会会誌   Vol. 32   page: 84-87   2011.7

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  34. Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment. Reviewed

    Iwase A, Goto M, Manabe S, Hirokawa W, Kobayashi H, Nakahara T, Takikawa S, Kotani T, Sumigama S, Tsuda H, Nakayama T, Suzuki N, Matsushita T, Kikkawa F.

    Fertil Steril.   Vol. 95 ( 6 ) page: 2124.e5-7.   2011.5

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  35. The post-operative decline in serum anti-Mullerian hormone correlates with the bilaterality and severity of endometriosis. Reviewed

    Hirokawa W, Iwase A, Goto M, Takikawa S, Nagatomo Y, Nakahara T, Bayasula B, Nakamura T, Manabe S, Kikkawa F.

    Hum Reprod.   Vol. 26 ( 4 ) page: 904-910   2011.4

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  36. Serum anti-Müllerian hormone level is a useful marker for evaluating the impact of laparoscopic cystectomy on ovarian reserve. Reviewed

    Iwase A, Hirokawa W, Goto M, Takikawa S, Nagatomo Y, Nakahara T, Manabe S, Kikkawa F.

    Fertil Steril   Vol. 94 ( 7 ) page: 2846-2849   2010.10

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  37. Assessment of the predictive value of follicular fluid insulin, leptin and adiponectin in assisted reproductive cycles. Reviewed

    Takikawa S, Iwase A, Goto M, Harata T, Umezu T, Nakahara T, Kobayashi H, Suzuki K, Manabe S, Kikkawa F.

    Gynecol Endocrinol.   Vol. 26 ( 7 )   2010.7

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  38. Three-dimensional CT angiography is useful for diagnosis of postabortion uterine hemorrhage: 3 case reports and review of the literature. Reviewed

      Vol. 17 ( 2 ) page: 246-51   2010.3

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  39. Evaluation of the safety of time-lapse observations for human embryos. Reviewed

    Nakahara T, Iwase A, Goto M, Harata T, Suzuki M, Ienaga M, Kobayashi H, Takikawa S, Manabe S, Kikkawa F, Ando H.

    J Assist Reprod Genet.   Vol. 27 ( 2-3 ) page: 93-6   2010.2

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  40. Serum anti-Müllerian hormone level is a useful marker for evaluating the impact of laparoscopic cystectomy on ovarian reserve.

    Iwase A, Hirokawa W, Goto M, Takikawa S, Nagatomo Y, Nakahara T, Manabe S, Kikkawa F.

    Fertil Steril.   Vol. in press   2010

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  41. Insulin attenuates the insulin-like growth factor-I (IGF-I)-Akt pathway, not IGF-I-extracellularly regulated kinase pathway, in luteinized granulosa cells with an increase in PTEN. Reviewed

    Iwase A, Goto M, Harata T, Takigawa S, Nakahara T, Suzuki K, Manabe S, Kikkawa F.

    J Clin Endocrinol Metab   Vol. 94 ( 6 ) page: 2184-2191   2009.3

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  42. 帝王切開術後の切開部菲薄化筋層に対し外科的治療を施した3例

    岩瀬 明, 鈴木 恭輔, 中原 辰夫, 小林 浩治, 滝川 幸子, 真鍋 修一, 梅津 朋和, 後藤 真紀, 吉川 史隆

    産婦人科の実際   Vol. 58 ( 3 ) page: 495-499   2009.3

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  43. Scar endometriosis after a laparotomy for uterine perforation as a complication of dilatation and curettage. Reviewed

    Kurotsuchi S, Iwase A, Goto M, Hariyama Y, Kikkawa F.

    Arch Gynecol Obstet.   Vol. 279 ( 6 ) page: 941-943   2009.2

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  44. Oral progestogen versus intramuscular progesterone for luteal support after ART treatment: A prospective randomized study Reviewed

    Akira Iwase, Hisao Ando, Shigeru Toda, Shino Ishimatsu, Toko Harata, Shozo Kurotsuchi, Yuji Shimomura, Maki Goto, Fumitaka Kikkawa

    Arch Gynecol Obstet   Vol. 277 ( 4 ) page: 319-324   2008.4

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  45. Successful management of a massive hemorrhage due to rupture of cystic cervical endometriosis by a loop electrosurgical excision procedure Reviewed

    Iwase A, Goto M, Kurotsuchi S, Harata T, Kaseki S, Kikkawa F

    Fertil Steril   Vol. 89 ( 4 ) page: e13-15   2008.4

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  46. Distribution of endothelin-converting enzyme-1 and neutral endopeptidase in human endometrium Reviewed

    Akira Iwase, Hisao Ando, Tetsuro Nagasaka, Maki Goto, Toko Harata, and Fumitaka Kikkawa

    J Histochem Cytochem   Vol. 55 ( 12 ) page: 1229-1235   2007.12

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  47. Neutral endopeptidase expressed by decidualized stromal cells suppresses akt phosphorylation and deoxyribonucleic acid synthesis induced by endothelin-1 in human endometrium. Reviewed

    Iwase A, Ando H, Nagasaka T, Shibata D, Harata T, Shimomura Y, Goto M, Kikkawa F

    Endocrinology   Vol. 147   page: 5153-5159   2006.11

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  48. 大量腹腔内出血を呈し,卵巣癌との鑑別を要したGISTの1例

    後藤 真紀, 梶山 広明, 小谷 友美, 柴田 清住, 井箟 一彦, 野村 誠二, 吉川 史隆

    産科と婦人科   Vol. 73 ( 2 ) page: 269-273   2006.2

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Presentations 13

  1. 酸性タイロード処理によりハッチングに要する時間は短縮する −タイムラプスシネマトグラフィーを用いたマウス胚の経時的観察による検討−

    後藤真紀 小林晴美 古澤直美 巴雅蘇拉 杉田敦子 近藤美佳  中原辰夫 小林浩治 滝川幸子 眞鍋修一 岩瀬 明 吉川史隆

    第56回日本生殖医学会学術講演会 

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    Event date: 2011.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神奈川県横浜市   Country:Japan  

  2. The analysis for effects of hatching with the time-lapse observations International conference

    M. GOTO, H. KOBAYASHI, N. FURUSAWA, A. SUGITA, M. KONDO, T. NAKAMURA, H. KOBAYASHI,  T. NAKAHARA, S. TAKIKAWA, S. MANABE, A. IWASE, F. KIKKAWA

    World Congress on Reproductive Biology 

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    Event date: 2011.10

    Language:English   Presentation type:Poster presentation  

    Venue:Cairns, Australia   Country:Australia  

  3. 卵胞液プロテオーム解析を用いた卵胞発育および卵成熟機構に関与する因子についての検討

    後藤真紀, 岩瀬明, 中村智子, 廣川和加奈, 中原辰夫, 小林浩治, 滝川幸子, 眞鍋修一, 吉川史隆

    第63回日本産科婦人科学会学術講演会 

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    Event date: 2011.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪府大阪市   Country:Japan  

  4. 体外受精-胚移植周期での不安ストレスの周期的変動および、患者背景や性差に伴う変動の比較検討

    後藤真紀, 原田統子, 吉川典子, 中村智子, 廣川和加奈, 中原辰夫, 滝川幸子, 小林浩治, 眞鍋修一, 岩瀬明, 吉川史隆

    第55回日本生殖医学会学術講演会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島県徳島市   Country:Japan  

  5. 体外受精一胚移植後に発生し、診断に苦慮した虫垂炎の1例

    後藤真紀, 眞鍋修一, 中村智子, 広川和加奈, 中原辰夫, 杉山知里, 小林浩治, 滝川幸子, 岩瀬明, 吉川史隆

    平成22年度日本生殖医学会中部支部学術集会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知県名古屋市   Country:Japan  

  6. 体外受精-胚移植周期における心理ストレスの周期的変動や患者背景についての検討

    後藤真紀, 原田統子, 廣川和加奈, 中原辰夫, 小林浩治, 滝川幸子, 眞鍋修一, 黒土升蔵, 岩瀬明, 吉川史隆

    第9回日本不妊カウンセリング学会学術集会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京都港区   Country:Japan  

  7. 体外受精-胚移植における禁煙指導の有用性についての検討

    後藤真紀, 岩瀬明, 廣川和加奈, 中原辰夫, 小林浩治, 滝川幸子, 眞鍋修一, 吉川史隆

    第62回日本産科婦人科学会学術講演会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京都中央区   Country:Japan  

  8. 行政による不妊相談に男性は何を求めているか

    第60回日本産科婦人科学会学術講演会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  9. インスリン投与によるヒト黄体化顆粒膜細胞でのPTENの発現変化

    第52回日本生殖医学会学術講演会 

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    Event date: 2007.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  10. ヒト顆粒膜細胞のインスリン投与によるIGF-1に対する反応性の変化およびPTENの発現の変化について

    第25回日本受精着床学会学術講演会 

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    Event date: 2007.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  11. 公的相談センターでの医師面接に求められているものとは?

    第6回日本不妊カウンセリング学会学術集会 

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    Event date: 2007.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  12. ラットPCOモデルにおけるPTENおよびAktの発現について

    第59回日本産科婦人科学会学術講演会 

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    Event date: 2007.4

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  13. ヒト顆粒膜細胞の黄体化周辺におけるIGF-1に対する反応性の変化

    第24回日本受精着床学会学術講演会 

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    Event date: 2006.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. リプロダクティブヘルスケア/ライツ啓発を組み入れた新規早発卵巣不全予測法の検証

    Grant number:20K11508  2020.4 - 2023.3

    後藤 真紀

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    若い世代への加齢による卵の質の低下や卵巣予備能の啓発は重要である。また早発卵巣不全という疾患は40 歳未満で 1-2/100の発症率と稀な疾患ではないが、原因不明であり発症後の治療や自己卵子での妊娠が非常に困難となる疾患である。本研究では講義形式のみの受動的な啓発手法に加えて、能動的に卵巣予備能を測定し自身の卵巣予備能について認識してもらう啓発プログラムの有効性を検証し、早発卵巣不全ハイリスク患者の抽出とリスク因子を解析することで、早発卵巣不全の早期発見を可能にするスクリーニング法の開発と検証を同時に行う。

  2. 顆粒膜細胞障害に着目した子宮内膜症における卵胞発育障害の解明

    Grant number:20K09615  2020.4 - 2023.3

    中村 智子

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    Authorship:Coinvestigator(s) 

    内膜症による卵胞発育障害の機序を、炎症と線維化による顆粒膜細胞障害から解明し、排卵を抑制しない新規内膜症治療薬の開発を目的とする。機序の解明に際し、効果的な阻害剤や補充療法を選定し、マウスモデルを用いて新規治療薬としての効果判定を行う。他疾患と共通する機序が見出されれば、既存の臨床治療薬が内膜症治療に応用可能か調べる。さらに内膜症に限らず、同じく線維化が主病態である卵巣の加齢・早発機能不全(POF)・がん生殖においても卵胞機能保全の方策の一助とする。

  3. 多嚢胞性卵巣症候群に関与するゲノムインプリンティング解析と発症予測マーカー考案

    Grant number:17K11228  2017.4 - 2018.3

    滝川 幸子

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    Authorship:Coinvestigator(s) 

    多嚢胞性卵巣症候群 (polycystic ovarian syndrome; PCOS)の病態には内分泌異常と糖代謝異常が複雑に関与しており、その発症には遺伝的要素と胎内環境が影響していると考えられているがはっきりとした原因は解明されていない。成人期慢性疾患の発症基盤には胎児期の環境が関連するという胎児プログラミング仮説が提唱されており、ゲノムインプリンティングの関与が示唆されている。肥満や耐糖能異常などの原因遺伝子として注目されているInsulin like Growth Factor 2(IGF2)遺伝子の発現がPCOS発症の予測遺伝子となりうるか検討した。
    PCOS症例と非PCOS症例におけるIGF2の発現を比較するため、体外受精時に採取した顆粒膜細胞からRNAを分離し半定量PCRにて測定したところ、明らかな優位差は認められなかった。
    次にゲノムインプリンティングによるIGF2遺伝子発現調整を評価するため、differentially methylated region(DMR)領域のメチル化比率を定量解析を行うこととした。非POCS症例4例の全血からDNAを分離しパイロシークエンス法を用いて解析を行ったが、うち1例は検体不良であった。IGF2-DMR0領域にはCpGサイトが3か所含まれており、既報のメチル化比率と一致を確認した。PCOS症例のDNAメチル化比率を測定していないため十分な検討はできなかった。
    クローニングが不要なパイロシークエンス法は簡便であるが、ターゲットとなるDMR領域の選定が重要であると考えられた。IGF2遺伝子以外のインプリンティング遺伝子もPCOS発症に関与している候補と考えれるため検討課題と考えられた。

  4. Elucidation of folliculogenesis by spatio-temporal investigation

    Grant number:15H04984  2015.4 - 2018.3

    Iwase Akira

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    The purpose of our project was to analyze the mechanism of early follicle development and consequently develop new drugs for ovarian stimulation and ex vivo ovarian tissue culture system.
    We established visualized murine ovarian tissue culture system and identified GDF-9, bFGF and IGF-1 as a stimulating factor and AMH as an inhibiting factor for follicle development. We also identified kisspeptin and phonexin as a novel peptide factor inducing follicle development.
    We demonstrated that the factors mentioned above induced follicle development in ex vivo murine ovarian tissue culture and efficiently produced matured oocytes. However, the investigation using human ovarian tissues revealed that ex vivo-induction of follicle development was not feasible because of the differences in ovarian sizes and follicle growth cycles.

  5. 経時的連続観察を利用した卵巣体外培養系の確立と応用

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  6. プロテオーム解析を用いた良好胚獲得のための基礎的検討および新規排卵誘発法法の開発

    2011.4 - 2013.3

    科学研究費補助金  若手研究(B)

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  7. ヒト顆粒膜細胞発育とPTEN誘導に関連した新規排卵誘発剤の開発

    2009 - 2010

    科学研究費補助金  科研費:若手研究(B),課題番号:21791549

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Social Contribution 1

  1. 愛知県不妊・不育専門相談センター

    2010

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    不妊・不育についてのカウンセリング・医師面接相談
    不妊・不育公開講座