Updated on 2021/06/29

写真a

 
HASHIMOTO, Naozumi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Internal Medicine Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor

Degree 1

  1. PhD ( 2002.3   Nagoya University ) 

Research Interests 1

  1. Respiratory Disease, Tissue microenvironment, Fibroblasts, Heterogeneity, Cell Origins

Research Areas 1

  1. Others / Others  / Respiratory Organ Internal Medicine

Current Research Project and SDGs 3

  1. COPD/間質性肺炎の慢性呼吸器疾患がもたらす組織微小環境と肺癌

  2. 血管内皮間葉系細胞転換機序を標的とした肺線維症および肺高血圧症の治療戦略の構築

  3. Heterogeneity of Fibroblasts and its Origins in Pulmonary Fibrosis

Research History 4

  1. Nagoya Univrsity Graduate School of medicine, Department of Respiratory Medicine   Associate professor

    2018.5

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    Country:Japan

  2. 名古屋大学医学部附属病院 呼吸器内科 講師

    2015.5 - 2018.4

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    Country:Japan

  3. Lecturer, Department of Respiratory Medicine, Nagoya University Hospital

    2013.4 - 2015.4

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    Country:Japan

  4. Assistant Professor

    2007.9

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Medicine   Internal Medicine

    1998.4 - 2002.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1988.4 - 1994.3

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    Country: Japan

Professional Memberships 11

  1. 日本内科学会   専門医

    2005.4

  2. 日本呼吸器学会   指導医

    2012.12

  3. 日本アレルギー学会   指導医

    2009.4

  4. 日本呼吸器内視鏡学会   気管支鏡専門医

    2013.12

  5. 日本呼吸器内視鏡学会   気管支鏡指導医

    2019.12

  6. 日本癌学会

    2009.4

  7. 日本肺癌学会

    1997.6

  8. American Thoracic Society   Member

    2008.4

  9. 日本臨床腫瘍学会

    2011.9

  10. European Respiratory Society   Member

    2011.6

  11. 日本リウマチ学会

    2008.4

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Committee Memberships 13

  1. 日本呼吸器学会   理事  

    2020.4   

  2. 日本内科学会 評議員   評議員  

    2017.4 - 2021.4   

  3. 日本呼吸器学会 代議員   代議員  

    2014.2   

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    Committee type:Academic society

  4. 日本呼吸器学会 幹事   幹事  

    2018.4 - 2020.4   

  5. 日本肺癌学会 評議員   日本肺癌学会評議員  

    2018.12   

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    Committee type:Academic society

  6. 日本内科学会 第116回講演会 準備委員長   準備委員長  

    2017.4 - 2019.4   

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    Committee type:Academic society

  7. 日本呼吸器学会 学術講演会プログラム委員会   学術講演会プログラム委員  

    2018.4 - 2020.9   

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    Committee type:Academic society

  8. 第30回日本医学会総会2019中部 総務委員会   総務委員会 幹事  

    2014.4 - 2019.5   

  9. 日本呼吸器学会 財務委員会   委員  

    2016.4 - 2020.4   

  10. 日本呼吸器学会 国際委員会   委員  

    2016.4   

  11. 日本呼吸器学会 将来計画委員会   将来計画委員  

    2018.4   

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    Committee type:Academic society

  12. 日本呼吸器学会 細胞・分子生物学学術部会   プログラム委員  

    2012.6   

  13. 日本肺癌学会AI開発小委員会   日本肺癌学会AI開発小委員会委員  

    2018.12   

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    Committee type:Academic society

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Awards 4

  1. 第21回 Pneumo Forum 特別賞

    2012.11   第21回 Pneumo Forum  

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    Country:Japan

  2. 第14回マクロライド新作用研究会研究奨励賞

    2008.7   マクロライド新作用研究会  

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    Country:Japan

  3. 第12回ALI研究会研究奨励賞

    2008.2   Acute Lung Injury 研究会  

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    Country:Japan

  4. 21世紀COE研究奨励賞

    2007.6  

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    Country:Japan

 

Papers 107

  1. Fibroblasts positive for meflin have anti-fibrotic property in pulmonary fibrosis. Reviewed

    Nakahara Y(#), Hashimoto N (#), Sakamoto K(#), Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y.

    European Respiratory Journal     2021.5

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    Authorship:Lead author, Last author, Corresponding author  

    DOI: 10.1183/13993003.03397-2020

  2. Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages. Reviewed

    Inoue M, Sakamoto K, Suzuki A, Nakai S, Ando A, Shiraki Y, Nakahara Y, Omura M, Enomoto A, Nakase I, Sawada M, Hashimoto N.

    Part Fibre Toxicol     2021.4

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12989-021-00415-0

  3. The Importance of Appropriate Diagnosis in the Practical Management of Chronic Obstructive Pulmonary Disease Invited Reviewed

    Naozumi Hashimoto, Keiko Wakahara, Koji Sakamoto

    Diagnostics   Vol. 11 ( 4 ) page: 618   2021.3

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    Authorship:Lead author, Corresponding author   Language:English  

    DOI: 10.3390/diagnostics11040618

  4. Impact of post-capillary pulmonary hypertension on mortality in interstitial lung disease Reviewed

    Teramachi R, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Yokoyama T, Furukawa T, Yagi M, Sakamoto K, Hashimoto N, Hasegawa Y.

    Respiratory Investigation   Vol. 59 ( 3 ) page: 342 - 349   2021.5

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    Language:English  

    DOI: 10.1016/j.resinv.2020.12.010

  5. Intractable diffuse pulmonary diseases: Manual for diagnosis and treatment Reviewed

    Homma, Sakae; Ebina, Masahito; Kuwano, Kazuyoshi; Goto, Hisatsugu; Sakai, Fumikazu; Sakamoto, Susumu; Johkoh, Takeshi; Sugino, Keishi; Tachibana, Teruo; Terasaki, Yasahiro; Nishioka, Yasuhiko; Hagiwara, Koichi; Hashimoto, Naozumi; Hasegawa, Yoshinori; Hebisawa, Akira

    Respiratory Investigation   ( 59 ) page: 8 - 33   2021.1

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  6. Serum mitochondrial DNA predicts the risk of acute exacerbation and progression of idiopathic pulmonary fibrosis Reviewed

    Koji Sakamoto, Taiki Furukawa, Yasuhiko Yamano, Kensuke Kataoka, Ryo Teramachi, Anjali Walia, Atsushi Suzuki, Masahide Inoue, Yoshio Nakahara, Changwan Ryu, Naozumi Hashimoto, Yasuhiro Kondoh

    European Respiratory Journal   Vol. 57 ( 1 ) page: 2001346   2021.1

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    Language:English  

    DOI: 10.1183/13993003.01346-2020

  7. Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state Invited Reviewed

    Norihito Omote, Koji Sakamoto, Qin Li, Jonas C Schupp, Taylor Adams, Farida Ahangari, Maurizio Chioccioli, Giuseppe DeIuliis, Naozumi Hashimoto, Yoshinori Hasegawa, Naftali Kaminski

    Physiol Rep   Vol. 9 ( 3 ) page: e14727   2021.2

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    Language:English  

    DOI: 10.14814/phy2.14727

  8. Efficacies of programmed cell death 1 ligand 1 blockade in non-small cell lung cancer patients with acquired resistance to prior programmed cell death 1 inhibitor and development of diabetic ketoacidosis caused by two different etiologies: a retrospective case series. Reviewed

    Ishi A, Tanaka I, Iwama S, Sakakibara T, Mastui T, Kobayashi T, Hase T, Morise M, Sato M, Arima H, Hashimoto N

    Endocrine Journal   Vol. 68 ( 5 ) page: 613 - 620   2021.5

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1507/endocrj.EJ20-0769.

  9. Clinical burden of immune checkpoint inhibitor-induced pneumonitis Invited Reviewed

    Sakamoto, Koji; Fukihara, Jun; Morise, Masahiro; Hashimoto, Naozumi

    Respiratory Investigation     2020.9

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    Authorship:Corresponding author  

    DOI: doi.org/10.1016/J.RESINV.2020.05.008

  10. Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study Reviewed

    Kobayashi, Tomoko; Iwama, Shintaro; Yasuda, Yoshinori; Okada, Norio; Okuji, Takayuki; Ito, Masaaki; Onoue, Takeshi; Goto, Motomitsu; Sugiyama, Mariko; Tsunekawa, Taku; Takagi, Hiroshi; Hagiwara, Daisuke; Ito, Yoshihiro; Suga, Hidetaka; Banno, Ryoichi; Yokota, Kenji; Hase, Tetsunari; Morise, Masahiro; Hashimoto, Naozumi; Ando, Masahiko; Fujimoto, Yasushi; Hibi, Hideharu; Sone, Michihiko; Ando, Yuichi; Akiyama, Masashi; Hasegawa, Yoshinori; Arima, Hiroshi

    Journal for ImmunoTherapy of Cancer     2020.7

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  11. Omalizumab for Aspirin Hypersensitivity and Leukotriene Overproduction in Aspirin-exacerbated Respiratory Disease A Randomized Controlled Trial Reviewed

    Hayashi, Hiroaki; Fukutomi, Yuma; Mitsui, Chihiro; Kajiwara, Keiichi; Watai, Kentaro; Kamide, Yosuke; Nakamura, Yuto; Hamada, Yuto; Tomita, Yasuhiro; Sekiya, Kiyoshi; Tsuburai, Takahiro; Izuhara, Kenji; Wakahara, Keiko; Hashimoto, Naozumi; Hasegawa, Yoshinori; Taniguchi, Masami

    American Journal of Respiratory and Critical Care Medicine     2020.6

  12. Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study Invited Reviewed

    Okada, Norio; Iwama, Shintaro; Okuji, Takayuki; Kobayashi, Tomoko; Yasuda, Yoshinori; Wada, Eri; Onoue, Takeshi; Goto, Motomitsu; Sugiyama, Mariko; Tsunekawa, Taku; Takagi, Hiroshi; Hagiwara, Daisuke; Ito, Yoshihiro; Suga, Hidetaka; Banno, Ryoichi; Hase, Tetsunari; Morise, Masahiro; Kanda, Mitsuro; Yokota, Kenji; Hashimoto, Naozumi; Ando, Masahiko; Fujimoto, Yasushi; Nagino, Masato; Kodera, Yasuhiro; Fujishiro, Mitsuhiro; Hibi, Hideharu; Sone, Michihiko; Kiyoi, Hitoshi; Gotoh, Momokazu; Ando, Yuichi; Akiyama, Masashi; Hasegawa, Yoshinori; Arima, Hiroshi

    British Journal of Cancer     2020.3

  13. Comparing incidences of infusion site reactions between brand-name and generic vinorelbine in patients with non-small cell lung cancer Reviewed

    Ozawa, Naoya; Hase, Tetsunari; Hatta, Takahiro; Sagara, Atsunobu; Ichikawa, Kazuya; Miyazaki, Masayuki; Yogo, Naoyuki; Ando, Masahiko; Hashimoto, Naozumi; Yamada, Kiyofumi; Hasegawa, Yoshinori

    British Journal of Clinical Pharmacology     2020.8

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  14. Involvement of heme oxygenase-1 in suppression of T cell activation by quercetin Reviewed

    Sugiyama, Tomoshi; Matsushima, Miyoko; Ohdachi, Tomoko; Hashimoto, Naozumi; Hasegawa, Yoshinori; Yokoi, Kohei; Kawabe, Tsutomu

    Immunopharmacology and Immunotoxicology     2020.7

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  15. Reply to "Prognostic Impact and Risk Factors of Immune-Related Pneumonitis in Patients With NoneSmall-Cell Lung Cancer Who Received Programmed Death-1 Inhibitors" Reviewed

    Fukihara, Jun; Sakamoto, Koji; Koyama, Junji; Ito, Takayasu; Iwano, Shingo; Morise, Masahiro; Ogawa, Masahiro; Kondoh, Yasuhiro; Kimura, Tomoki; Hashimoto, Naozumi; Hasegawa, Yoshinori

    Clinical Lung Cancer     2020.5

  16. Endobronchial ultrasound-guided transbronchial needle aspiration under non-invasive positive pressure for the diagnosis of lung metastasis due to renal cell carcinoma in a patient with respiratory failure Reviewed

    Ito, Takayasu; Okachi, Shotaro; Ikenouchi, Tadasuke; Ushijima, Futoshi; Ohashi, Takamasa; Ogawa, Masahiro; Nagahama, Masato; Wakahara, Keiko; Hashimoto, Naozumi

    Respiratory Medicine Case Reports     2020.1

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    Authorship:Last author  

    DOI: doi.org/10.1016/J.RMCR.2020.101028

  17. Unusual presentation of recurrent follicular lymphoma as diffuse granular shadow Reviewed

    Takayasu Ito Shotaro Okachi Yuichi Ishikawa Satoko Shimada Keiko Wakahara Naozumi Hashimoto

    Respirology Case Reports   Vol. 9 ( 3 ) page: e00710   2021.3

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    DOI: https://doi.org/10.1002/rcr2.710

  18. Bronchial wall thickening is associated with severity of chronic rhinosinusitis Reviewed

    Majima, Suguru; Wakahara, Keiko; Nishio, Tomoko; Nishio, Naoki; Teranishi, Masaaki; Iwano, Shingo; Hirakawa, Akihiro; Hashimoto, Naozumi; Sone, Michihiko; Hasegawa, Yoshinori

    Respiratory Medicine     2020.8

  19. Primary Prophylaxis Indication for Docetaxel Induced Febrile Neutropenia in Elderly Patients with Non-Small Cell Lung Cancer Invited Reviewed

    Matsui, Akira; Morise, Masahiro; Tanaka, Ichidai; Ozone, Sachiko; Matsuzawa, Reiko; Koyama, Junji; Hase, Tetsunari; Hashimoto, Naozumi; Sato, Mitsuo; Hasegawa, Yoshinori

    Cancer Investigation     2020.8

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  20. High-flow nasal cannula therapy for acute respiratory failure in patients with interstitial pneumonia: a retrospective observational study Invited Reviewed

    Omote, Norihito; Matsuda, Naoyuki; Hashimoto, Naozumi; Nishida, Kazuki; Sakamoto, Koji; Ando, Akira; Nakahara, Yoshio; Nishikimi, Mitsuaki; Higashi, Michiko; Matsu, Shigeyuki; Hasegawa, Yoshinori

    Nagoya Journal of Medical Science     2020.5

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  21. Thrombomodulin Alfa for Acute Exacerbation of Idiopathic Pulmonary Fibrosis A Randomized, Double-Blind Placebo-controlled Trial Reviewed

    Kondoh, Yasuhiro; Azuma, Arata; Inoue, Yoshikazu; Ogura, Takashi; Sakamoto, Susumu; Tsushima, Kenji; Johkoh, Takeshi; Fujimoto, Kiminori; Ichikado, Kazuya; Matsuzawa, Yasuo; Saito, Takefumi; Kishi, Kazuma; Tomii, Keisuke; Sakamoto, Noriho; Aoshima, Masahiro; Araya, Jun; Izumi, Shinyu; Arita, Machiko; Abe, Mitsuhiro; Yamauchi, Hiroyoshi; Shindoh, Joe; Suda, Takafumi; Okamoto, Masaki; Ebina, Masahito; Yamada, Yoshihito; Tohda, Yuji; Kawamura, Tetsuji; Taguchi, Yoshio; Ishii, Hiroshi; Hashimoto, Naozumi; Abe, Shinji; Taniguchi, Hiroyuki; Tagawa, Jun; Bessho, Koji; Yamamori, Natsuki; Homma, Sakae

    American Journal of Respiratory and Critical Care Medicine     2020.5

  22. Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer Reviewed

    Shimizu, Takahiro; Okachi, Shotaro; Imai, Naoyuki; Hase, Tetsunari; Morise, Masahiro; Hashimoto, Naozumi; Sato, Mitsuo; Hasegawa, Yoshinori

    NAGOYA JOURNAL OF MEDICAL SCIENCE     2020.2

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  23. Acute exacerbations of fibrotic interstitial lung diseases Reviewed

    Suzuki, Atsushi; Kondoh, Yasuhiro; Brown, Kevin K.; Johkoh, Takeshi; Kataoka, Kensuke; Fukuoka, Junya; Kimura, Tomoki; Matsuda, Toshiaki; Yokoyama, Toshiki; Fukihara, Jun; Ando, Masahiko; Tanaka, Tomonori; Hashimoto, Naozumi; Sakamoto, Koji; Hasegawa, Yoshinori

    Respirology     2020.5

  24. Repressive role of stabilized HIF1α expression on TGFβ-induced extracellular matrix production in lung cancer cells Reviewed

    Ando A, Hashimoto N, Sakamoto K, Omote N, Miyazaki S, Nakahara Y, Imaizumi K, Kawabe T, Hasegawa Y

    Cancer Sci     2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14027

  25. Probable usual interstitial pneumonia pattern on chest CT: is it sufficient for a diagnosis of idiopathic pulmonary fibrosis? Invited Reviewed

    Fukihara, Jun; Kondoh, Yasuhiro; Brown, Kevin K.; Kimura, Tomoki; Kataoka, Kensuke; Matsuda, Toshiaki; Yamano, Yasuhiko; Suzuki, Atsushi; Furukawa, Taiki; Sumikawa, Hiromitsu; Takahashi, Osamu; Johkoh, Takeshi; Tanaka, Tomonori; Fukuoka, Junya; Hashimoto, Naozumi; Hasegawa, Yoshinori

    European Respiratory Journal     2020.4

  26. Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation Reviewed

    Murakami, Yasushi; Sakamoto, Koji; Okumura, Yuki; Suzuki, Atsushi; Mii, Shinji; Sato, Mitsuo; Yokoi, Toyoharu; Hashimoto, Naozumi; Hasegawa, Yoshinori

    Internal Medicine     2020.11

  27. Performance of the COPD Assessment Test in patients with connective tissue disease-associated interstitial lung disease. Reviewed

    Suzuki A, Kondoh Y, Swigris JJ, Matsuda T, Kimura T, Kataoka K, Ando M, Hashimoto N, Sakamoto K, Hasegawa Y

    Respir Med   Vol. 150   page: 15-20   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.rmed.2019.01.017.

  28. Potential for afatinib as an optimal treatment for advanced non-small cell lung carcinoma in patients with uncommon EGFR mutations. Reviewed

    Tanaka I, Morise M, Kodama Y, Matsui A, Ozawa N, Ozone S, Goto D, Miyazawa A, Hase T, Hashimoto N, Sato M, Hasegawa Y

    Lung Cancer   Vol. 127   page: 169-171   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan.2018.11.018

  29. Exogenous induction of unphosphorylated PTEN reduces TGFβ-induced extracellular matrix expressions in lung fibroblasts. Reviewed

    Kimura M, Hashimoto N, Kusunose M, Aoyama D, Sakamoto K, Miyazaki S, Ando A, Omote N, Imaizumi K, Kawabe T, Hasegawa Y

    Wound Repair and Regeneration     2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/wrr.12506.

  30. Antineutrophil Cytoplasmic Antibody-associated Vasculitis Superimposed on Infection-related Glomerulonephritis Secondary to Pulmonary Mycobacterium avium Complex Infection. Reviewed

    Asano S, Mizuno S, Okachi S, Aso H, Wakahara K, Hashimoto N, Ito S, Kozaki Y, Katsuno T, Maruyama S, Hasegawa Y

    Intern Med   Vol. 55   page: 2439-2445   2016.8

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  31. Outcomes with newly proposed classification of acute respiratory deterioration in idiopathic pulmonary fibrosis. Reviewed

    Teramachi R, Kondoh Y, Kataoka K, Taniguchi H, Matsuda T, Kimura T, Yokoyama T, Yamano Y, Furukawa T, Sakamoto K, Hashimoto N, Hasegawa Y.

    Respir Med   Vol. 143   page: 147-152   2018.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  32. Factors Affecting the Diagnostic Yield of Transbronchial Biopsy Using Endobronchial Ultrasonography with a Guide Sheath in Peripheral Lung Cancer. Reviewed

    Okachi S, Imai N, Imaizumi K, Iwano S, Ando M, Hase T, Aso H, Morise M, Wakahara K, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y.

    Intern Med   Vol. 55   page: 1705-1712   2016.7

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  33. Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles Reviewed

    Sehsah, Radwa; Wu, Wenting; Ichihara, Sahoko; Hashimoto, Naozumi; Hasegawa, Yoshinori; Zong, Cai; Itoh, Ken; Yamamoto, Masayuki; Elsayed, Ahmed Ali; El-Bestar, Soheir; Kamel, Emily; Ichihara, Gaku

    Particle and Fibre Toxicology     2019.12

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  34. クリゾチニブの減感作療法により再投与が可能であった肺腺癌の1例 Reviewed

    佐野 将宏、橋本 直純、岡田 木綿、佐藤 光夫、宮崎 雅之、長谷川 好規

    肺癌   Vol. 56 ( 3 ) page: 215-218   2016.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  35. Impact of thin-section computed tomography-determined combined pulmonary fibrosis and emphysema on outcomes among patients with resected lung cancer Reviewed

    Hashimoto N, Iwano S, Kawaguchi K, Fukui T, Fukumoto K, Nakamura S, Mori S, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y

    Ann Thorac Surg   Vol. 102 ( 2 ) page: 440-447   2016.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.athoracsur.2016.03.014

  36. Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies Reviewed

    NAGOYA JOURNAL OF MEDICAL SCIENCE     2019.11

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  37. Prognostic Impact and Risk Factors of Immune-Related Pneumonitis in Patients With Non-Small-Cell Lung Cancer Who Received Programmed Death 1 Inhibitors Invited Reviewed

    Fukihara, Jun; Sakamoto, Koji; Koyama, Junji; Ito, Takayasu; Iwano, Shingo; Morise, Masahiro; Ogawa, Masahiro; Kondoh, Yasuhiro; Kimura, Tomoki; Hashimoto, Naozumi; Hasegawa, Yoshinori

    Clinical Lung Cancer     2019.11

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  38. Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers Reviewed

    Kohnoh T, Hashimoto N, Ando A, Sakamoto K, Miyazaki S, Aoyama D, Kusunose M, Kimura M, Omote N, Imaizumi K, Kawabe T, Hasegawa Y

    Cancer Cell International     2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12935-016-0308-3

  39. Renewed Japanese spirometric reference variables and risk stratification for postoperative outcomes in COPD patients with resected lung cancer Reviewed

    Okada, Yu; Hashimoto, Naozumi; Iwano, Shingo; Kawaguchi, Koji; Fukui, Takayuki; Sakamoto, Koji; Wakai, Kenji; Yokoi, Kohei; Hasegawa, Yoshinori

    NAGOYA JOURNAL OF MEDICAL SCIENCE     2019.8

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    Authorship:Corresponding author  

    DOI: doi.org/10.18999/NAGJMS.81.3.427

  40. 慢性閉塞性肺疾患(COPD)合併肺癌の術前評価と呼吸リハビリテーション Invited

    橋本 直純

    日本呼吸ケア・リハビリテーション学会誌   Vol. 25   page: 356-360   2015.12

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    Authorship:Lead author   Language:Japanese  

  41. Direct regulation of TGFβ-induced EMT by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells Reviewed

    Kusunose M, Hashimoto N, Kimura M, Ogata R, Aoyama D, Sakamoto K, Miyazaki S, Ando A, Omote N, Imaizumi K, Kawabe T, Hasegawa Y

    Cancer Science   Vol. 106   page: 1693-1704.   2015.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.12831

  42. Eosinophil Inflammation and Hyperresponsiveness in the Airways as Phenotypes of COPD, and Usefulness of Inhaled Glucocorticosteroids Invited Reviewed

    Hiroaki Kume; Masayuki Hojo; Naozumi Hashimoto

    FRONTIERS IN PHARMACOLOGY     2019.7

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  43. BK virus-associated viruria and viremia in a patient with lymphangioleiomyomatosis after lung re-transplantation: A case report and review of the literature on BK virus infection post-lung transplantation Invited Reviewed

    Okumura, Junya; Nakahara, Yoshio; Nakaguro, Masato; Shindo, Yuichiro; Hase, Tetsunari; Wakahara, Keiko; Hashimoto, Naozumi; Hasegawa, Yoshinori

    Journal of Infection and Chemotherapy     2019.10

  44. Clinical impact of the lower limit of normal of FEV1/FVC on survival in lung cancer patients undergoing thoracic surgery Reviewed

    Matsuzaki A, Hashimoto N, Okachi S, Taniguchi T, Kawaguchi K, Fukui T, Wakai K, Yokoi K, Hasegawa Y.

    Respir Investig     2015.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1016/j.resinv.2015.11.006.

  45. Prognosis of pulmonary fibrosis presenting with a usual interstitial pneumonia pattern on computed tomography in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis: a retrospective single-center study Invited Reviewed

    Watanabe, Toshikazu; Minezawa, Tomoyuki; Hasegawa, Midori; Goto, Yasuhiro; Okamura, Takuya; Sakakibara, Yosuke; Niwa, Yoshikazu; Kato, Atsushi; Hayashi, Masamichi; Isogai, Sumito; Kondo, Masashi; Yamamoto, Naoki; Hashimoto, Naozumi; Imaizumi, Kazuyoshi

    BMC Pulmonary Medicine     2019

  46. Risk stratification by the lower limit of normal of FEV1/FVC for postoperative outcomes in patients with COPD undergoing thoracic surgery. Reviewed

    Hashimoto N, Osuka S, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y

    Respir Investig   Vol. 53 ( 3 ) page: 117-23   2015.10

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    DOI: 10.1016/j.resinv.2015.01.005.

  47. Sublingual Swelling due to Sublingual Immunotherapy Reviewed

    Okumura J, Hashimoto N, Hasegawa Y

    J Allergy Clin Immunol Prac     2018.10

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    DOI: 10.1016/j.jaip.2018.09.010

  48. Bronchus sign on thin-section computed tomography is a powerful predictive factor for successful transbronchial biopsy using endobronchial ultrasound with a guide sheath for small peripheral lung lesions: a retrospective observational study Reviewed

    Minezawa T, Okamura T, Yatsuya H, Yamamoto N, Morikawa S, Yamaguchi T, Morishita M, Niwa Y, Takeyama T, Mieno Y, Hoshino T, Uozu S, Goto Y, Hayashi M, Isogai S, Matsuo M, Nakanishi T, Hashimoto N, Okazawa M, Imaizumi K

    BMC Medical Imaging     2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12880-015-0060-5

  49. Safety and efficacy of diagnostic flexible bronchoscopy in very old patients with lung cancer Reviewed

    Okachi S, Imaizumi K, Imai N, Shimizu T, Hase T, Morise M, Hashimoto N, Sato M, Hasegawa Y

    European Geriatric Medicine   Vol. 9 ( 2 ) page: 255-262   2018.4

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    DOI: https://doi.org/10.1007/s41999-018-0033-7

  50. Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute respiratory distress syndrome in mice. Reviewed

    Wakayama H, Hashimoto N, Matsushita Y, Matsubara K, Yamamoto N, Hasegawa Y, Ueda M, Yamamoto A.

    Cytotherapy     2015.5

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    DOI: 10.1016/j.jcyt.2015.04.009.

  51. Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study. Reviewed

    Kobayashi T, Iwama S,Yasuda Y, Okada N, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Morishita Y, Goto M, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H.

    Journal of the Endocrine Society   Vol. 2 ( 3 ) page: 241-251   2018.2

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  52. A scoring system to predict the elevation of mean pulmonary arterial pressure in idiopathic pulmonary fibrosis. Reviewed

    Furukawa T, Kondoh Y, Taniguchi1 H, Yagi M, Matsuda T, Kimura T, Kataoka K, Johkoh T, Ando M, Hashimoto N, Sakamoto K, Hasegawa Y

    Eur Respir J   Vol. 51   page: 1701311   2018.1

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  53. Evaluation of emphysema using three-dimensional computed tomography: association with postoperative complications in lung cancer patients Reviewed

    Kawakami K, Iwano S, Hashimoto N, Hasegawa Y, Naganawa S

    Nagoya J Med   Vol. 77 ( 1-2 ) page: 113-122   2015.2

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  54. Thin-section computed tomography-determined usual interstitial pneumonia pattern affects the decision-making process for resection in newly diagnosed lung cancer patients: a retrospective study. Reviewed

    Hashimoto N, Ando A, Iwano S, Sakamoto K, Okachi S, Matsuzaki A, Okada Y, Wakai K, Yokoi K, Hasegawa Y.

    BMC Pulm Med   Vol. 18 ( 1 ) page: 2   2018.1

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    DOI: 10.1186/s12890-017-0565-5. 2018.

  55. Synergistic Effect of Bolus Exposure to Zinc Oxide Nanoparticles on Bleomycin-Induced Secretion of Pro-Fibrotic Cytokines without Lasting Fibrotic Changes in Murine Lungs. Reviewed

    Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada-Oikawa S, Suzuki Y, Chang J, Kato M, D'Alessandro-Gabazza CN, Gabazza EC, Ichihara S

    Int J Mol Sci   Vol. 16 ( 1 ) page: 660-676   2015.1

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  56. Pseudomembranous Invasive Tracheobronchial Aspergillosis with Fulminant Hepatitis and Hemophagocytic Syndrome Reviewed

    Majima S, Okachi S, Asano M, Wakahara K, Hashimoto N, Sato M, Ishigami M, Hasegawa Y.

    Intern Med     2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.9673-17.

  57. Impact of mild to moderate COPD on feasibility and prognosis in non-small cell lung cancer patients who received chemotherapy. Reviewed

    Omote N, Hashimoto N, Morise M, Sakamoto K, Miyazaki S, Ando A, Nakahara Y, Hasegawa Y.

    Int J Chron Obstruct Pulmon Dis   Vol. 12   page: 3541-3547   2017.12

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    DOI: 10.2147/COPD.S149456.

  58. Lobar analysis of collapsibility indices to assess functional lung volumes in COPD patients. Reviewed

    Kitano M, Iwano S, Hashimoto N, Matsuo K, Hasegawa Y, Naganawa S

    Int J Chron Obstruct Pulmon Dis   Vol. 9   page: 1347-1356   2014.12

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  59. Feasibility of tissue re-biopsy in non-small cell lung cancers resistant to previous epidermal growth factor receptor tyrosine kinase inhibitor therapies. Reviewed

    Uozu S, Imaizumi K, Yamaguchi T, Goto Y, Kawada K, Minezawa T, Okamura T, Akao K, Hayashi M, Isogai S, Okazawa M, Hashimoto N, Hasegawa Y

    BMC Pulm Med   Vol. 17 ( 1 ) page: 175   2017.12

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    DOI: 10.1186/s12890-017-0514-3.

  60. A 63-Year-Old Woman With Progressive Dyspnea After Remission Of Lymphoma Reviewed

    Nishihara T, Nakano H, Nogami H, Katahira K, Ishimatsu A, Hashimoto N, Yokoi T, Iwanaga T

    Chest   Vol. 151 ( 3 ) page: e57-e62   2017.3

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    DOI: 10.1016/j.chest.2017.01.023

  61. Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury Reviewed

    Takashima K, Matsushima M, Hashimoto K, Nose H, Sato M, Hashimoto N, Hasegawa Y, Kawabe T

    Respiratory Research   Vol. 15 ( 1 ) page: 150   2014.11

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  62. 悪性リンパ腫の化学療法後に呼吸不全が進行し,閉塞性細気管支炎と診断された1 例 Reviewed

    西原 智恵、片平 雄之、野上 裕子、橋本 直純、岩永 知秋

    日呼吸誌   Vol. 3 ( 2 ) page: 281-286   2014.4

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  63. Clinical impact of prevalence and severity of COPD on the decision-making process for therapeutic management of lung cancer patients Reviewed

    Hashimoto N, Matsuzaki A, Okada Yu, Imai N, Iwano S, Wakai K, Imaizumi K, Yokoi K and Hasegawa Y

    BMC Pulmonary Medicine     2014.2

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    DOI: doi:10.1186/1471-2466-14-14

  64. Pirfenidone as salvage treatment for refractory bleomycin-induced lung injury: a case report of seminoma Reviewed

    Sakamoto K, Ito S, Hashimoto N, Hasegawa Y

    BMC Cancer   Vol. 17 ( 1 ) page: 526   2017.8

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    DOI: 10.1186/s12885-017-3521-0

  65. Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice. Reviewed

    Ohno T, Okamoto M, Hara T, Hashimoto N, Imaizumi K, Matsushima M, Nishimura M, Shimokata K, Hasegawa Y, Kawabe T.

    Immunogenetics   Vol. 65 ( 1 ) page: 17-24   2013

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  66. Modulation of immunological activity on macrophages induced by diazinon. Reviewed

    Ogasawara N, Matsushima M, Kawamura N, Atsumi K, Yamaguchi T, Ochi H, Kusatsugu Y, Oyabu S, Hashimoto N, Hasegawa Y, Ueyama J, Kawabe T.

    Toxicology     2017.1

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    DOI: 10.1016/j.tox.2017.01.014

  67. Selective IgA deficiency mimicking Churg-Strauss syndrome and hypereosinophilic syndrome: a case report. Reviewed

    Takahashi N, Kondo T, Fukuta M, Takemoto A, Takami Y, Sato M, Ando T, Hashimoto N, Suzuki T, Sato J, Yamamura M, Ban N.

    Nagoya J Med Sci   Vol. 75 ( 1-2 ) page: 139-146   2013

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  68. Endobronchial ultrasound transbronchial needle aspiration in older people. Reviewed

    Okachi S, Imai N, Imaizumi K, Hase T, Shindo Y, Sakamoto K, Aso H, Wakahara K, Hashimoto I, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y.

    Geriatr Gerontol Int     2013

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    DOI: doi: 10.1111/ggi.12043.

  69. Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells Reviewed

    Naozumi N, Aoyama D, Sakamoto K, Kohnoh T, Kusunose M, Kimura M, Ogata R, Imaizumi K, Kawabe T, Hasegawa Y

    PLOS ONE     2013

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    DOI: 10.1371/journal.pone.0081133

  70. Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury. Reviewed

    Hashimoto N, Sakamoto K, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y

    Am J Physiol Lung Cell Mol Physiol.     page: Epub ahead of print   2012.6

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    DOI: 10.1152/ajplung.00061.2012

  71. Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells. Reviewed

    Hashimoto N, Nakashima H, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.

    Mol Carcinog   Vol. 51   page: 400-410   2012.5

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    Nakashima H and Hashimoto N were contributed
    equally to this work.

    DOI: 10.1002/mc.20802.

  72. Inspiratory capacity as a preoperative assessment of patients undergoing thoracic surgery Reviewed

    Hashimoto N, Matsuo M, Usami N, Imaizumi K, Wakai K, Kawabe T, Yokoi K, Hasegawa Y

    Interact Cardiovasc Thorac Surg   Vol. 14 ( 5 ) page: 560-564   2012.2

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    DOI: 10.1093/icvts/ivr090

  73. Acute exacerbation of IPF following diagnostic bronchoalveolar lavage procedures Reviewed

    Sakamoto K, Taniguchi H, Kondoh Y, Wakai K, Kimura T, Kataoka K, Hashimoto N, Nishiyama O, Hasegawa Y

    Respir Med   Vol. 106 ( 3 ) page: 436-442   2012.3

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  74. Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells. Reviewed

    Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, Kawabe T

    Biochem Biophys Res Commun   Vol. 417 ( 1 ) page: 169-174   2012.1

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  75. Nongenomic effects of fluticasone propionate and budesonide on human airway anion secretion. Reviewed

    Mizutani T, Morise M, Ito Y, Hibino Y, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, Hasegawa Y.

    Am J Respir Cell Mol Biol   Vol. 47 ( 5 ) page: 645-651   2012

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  76. An aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans Reviewed

    Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y.

    Respirology     page: doi: 10.1111/j.1440-1843.2012.02286.x.   2012

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    DOI: doi: 10.1111/j.1440-1843.2012.02286.x.

  77. Mesenchymal Stem Cells Stably Transduced with a Dominant-Negative Inhibitor of CCL2 Greatly Attenuate Bleomycin-Induced Lung Damage. Reviewed

    Saito S, Nakayama T, Hashimoto N, Miyata Y, Egashira K, Nakao N, Nishiwaki S, Hasegawa M, Hasegawa Y, Naoe T

    Am J Pathol   Vol. 179 ( 3 ) page: 1088-1094   2011.9

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  78. CD40/CD40 ligand interactions in immune responses and pulmonary immunity Invited

    Kawabe T, Matsushima M, Hashimoto N, Imaizumi K, Hasegawa Y

    Nagoya J Med Sci   Vol. 73 ( 3-4 ) page: 69-78   2011.8

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  79. Identification of Autoantibodies against TRPM1 in Patients with Paraneoplastic Retinopathy Associated with ON Bipolar Cell Dysfunction. Reviewed

    Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T

    PLoS One   Vol. 6 ( 5 ) page: e19911   2011.5

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  80. Attenuation of TGF-ss-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-1. Reviewed

    Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T

    Am J Respir Cell Mol Biol   Vol. 44 ( 5 ) page: 614-620   2011.5

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  81. Capsaicinoids regulate airway anion transporters through Rho kinase- and cAMP-dependent mechanisms Reviewed

    Yoshitaka Hibino, Masahiro Morise, Yasushi Ito, Takefumi Mizutani, Tadakatsu Matsuno, Satoru Ito, Naozumi Hashimoto, Mitsuo Sato, Masashi Kondo, Kazuyoshi Imaizumi, and Yoshinori Hasegawa

    Am. J. Respir. Cell Mol. Biol.     2011

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    DOI: 10.1165/rcmb.2010-0332OC

  82. Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis Reviewed

    Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T, Shimokata K, Hasegawa Y

    Am J Respir Cell Mol Biol   Vol. 143   page: 161-172   2010.7

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  83. Differential Th1/Th2 chemokine expression in interstitial pneumonia. Reviewed

    Honda T., K. Imaizumi, T. Yokoi, N. Hashimoto, I. Hashimoto, T. Kawabe, M. Matsuo, S. Iwano, K. Shimokata, and Y. Hasegawa.

    Am J Med Sci.   Vol. 339   page: 41-48   2010.1

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  84. Heterologous regulation of anion transporters by menthol in human airway epithelial cells. Reviewed

    Morise M , Y. Ito, T. Matsuno, Y. Hibino, T. Mizutani, S. Ito, N. Hashimoto, M. Kondo, K. Imaizumi, and Y. Hasegawa.

    Eur J Pharmacol.   Vol. 635   page: 204-211   2010.1

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  85. Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lungcancer cells Reviewed

    Yoshihiro Takeyama, Mitsuo Sato, Mihoko Horio, Tetsunari Hase, Kenya Yoshida,Toshihiko Yokoyama, Harunori Nakashima, Naozumi Hashimoto, Yoshitaka Sekido,Adi F. Gazdar, John D. Minna, Masashi Kondo, Yoshinori Hasegawa

    Cancer Letters   Vol. 296   page: 216-224   2010

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  86. Health-care-associated pneumonia among hospitalized patients in a Japanese community hospital Reviewed

    Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Hashimoto N, Imaizumi K, Sato T, Hasegawa Y

    Chest   Vol. 135 ( 3 ) page: 633-640   2009

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    BACKGROUND: Health-care-associated pneumonia (HCAP) is a relatively new concept. Epidemiologic studies are limited, and initial empirical antibiotic treatment is still under discussion. This study aimed to reveal the differences in mortality and pathogens between HCAP and community-acquired pneumonia (CAP) in each severity class, and to clarify the strategy for the treatment of HCAP. METHODS: We conducted a retrospective observational study of patients with HCAP and CAP who were hospitalized between November 2005 and January 2007, and compared baseline characteristics, severity, pathogen distribution, antibiotic regimens, and outcomes. In each severity class (mild, moderate, and severe) assessed using the A-DROP scoring system (ie, age, dehydration, respiratory failure, orientation disturbance, and low BP), we investigated the in-hospital mortality and occurrence of potentially drug-resistant (PDR) pathogens. RESULTS: A total of 371 patients (141 HCAP patients, 230 CAP patients) were evaluated. The proportion of patients in the severe class was higher in the HCAP patients than in CAP patients. In the moderate class, the in-hospital mortality proportion of HCAP patients was significantly higher than that of CAP patients (11.1% vs 1.9%, respectively; p = 0.008). In moderate-class patients in whom pathogens were identified, PDR pathogens were isolated more frequently from HCAP patients than from CAP patients (22.2% vs 1.9%, respectively; p = 0.002). The occurrence of PDR pathogens was associated with initial treatment failure and inappropriate initial antibiotic treatment. CONCLUSIONS: The present study provides additional evidence that HCAP should be distinguished from CAP, and suggests that the therapeutic strategy for HCAP in the moderate class holds the key to improving mortality. Physicians may need to consider PDR pathogens in selecting the initial empirical antibiotic treatment of HCAP.

  87. An influence of Interferon-gamma gene polymorphisms on treatment response to tuberculosis in Japanese population Reviewed

    Shibasaki M, Yagi T, Yatsuya H, Okamoto M, Nishikawa M, Baba H, Hashimoto N, Senda K, Kawabe T, Nakashima K, Imaizumi K, Shimokata K, Hasegawa Y

    J Infect   Vol. 58 ( 6 ) page: 467-469   2009

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  88. Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis. Reviewed

    Shibasaki M, Hashimoto K, Okamoto M, Hayashi Y, Imaizumi K, Hashimoto N, Ozaki N, Yokoi T, Takagi K, Hasegawa Y, Shimokata K, Kawabe T

    Am J Respir Cell Mol Biol   Vol. 40 ( 5 ) page: 536-542   2009

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    Although Pneumocystis infection might be one of the causes of secondary pulmonary alveolar proteinosis (PAP), the mechanism of its pathogenesis is uncertain. We analyzed a mouse model of secondary PAP resulting from Pneumocystis infection using mice deficient in CD40 (CD40KO), and evaluated the mechanism of the pathogenesis of secondary PAP from the viewpoint of surfactant-associated protein (SP) homeostasis, the overproduction of SP by type II alveolar epithelial cells, and the phagocytic function of alveolar macrophages (AMs). The effect of CD40 on SP production was also investigated in vitro using the H441 cell line, which has a phenotype similar to type II alveolar epithelial cells and primary alveolar epithelial cells. After long-term exposure to ovalbumin, CD40KO mice showed Pneumocystis infection and accumulation of surfactants in the alveoli (ApCD40KO). The amounts of SP production were up-regulated in ApCD40KO mice compared with wild-type mice treated using the same procedure. On the other hand, AMs from ApCD40KO mice did not show either phagocytic dysfunction or down-regulation of PU.1 expression. Furthermore, the stimulation of CD40-CD40 ligand (CD154) pathway regulated the production of SPs in H441 cells or primary alveolar epithelial cells. These results suggested that CD40KO mice could be one of the models useful for developing secondary PAP resulting from Pneumocystis infection. Surfactant accumulation was due to the overproduction in our model of secondary PAP. The CD40-CD154 interaction plays an important role in the regulation of surfactant-associated protein production.

  89. Involvement of heme oxygenase-1 in kaempferol-induced anti-allergic actions in RBL-2H3 cells Reviewed

    Hirose E, Matsushima M, Takagi K, Ota Y, Ishigami K, Hirayama T, Hayashi Y, Nakamura T, Hashimoto N, Imaizumi K, Baba K, Hasegawa Y, Kawabe T

    Inflammation   Vol. 32 ( 2 ) page: 99-108   2009

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  90. *Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model. Reviewed

    Hashimoto N, Fujibayashi T, Jijiwa M, Hasegawa Y, Kojima T, Ishiguro N

    BMC Pulm Med   Vol. 9   page: 45   2009

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  91. *Erythromycin-induced CXCR4 expression on microvascular endothelial cell Reviewed

    Hashimoto N,Takagi Y, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Hashimoto I, Hayashi Y, Kawabe T, Shimokata K, Hasegawa Y

    Am J Physiol Lung Cell Mol Physiol   Vol. 297 ( 3 ) page: L420-L431   2009

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  92. TH1/TH2 immune response in lung fibroblasts in interstitial lung disease. Reviewed

    Sumida A, Hasegawa Y, Okamoto M, Hashimoto N, Imaizumi K, Yatsuya H, Yokoi T, Takagi K, Shimokata K, Kawabe T

    Arch Med Res   Vol. 39 ( 5 ) page: 503-510   2008

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    BACKGROUND: Inflammatory response in pulmonary fibrosis closely resembles a T-helper (Th) 2 immune response. For recruitment to an inflammatory lesion, the majority of Th1 cells express CXC chemokine receptor 3, recognizing monokine induced by interferon-gamma (Mig), interferon gamma-inducible protein of 10 kD (IP-10), and interferon-inducible T-cell alpha chemoattractant (I-TAC). Th2 cells express CC chemokine receptor 4, recognizing thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC). We investigated the Th1/Th2 chemokine production patterns by lung fibroblasts and their evaluation in bronchoalveolar lavage (BAL) fluid of interstitial lung disease. METHODS: The production pattern of Th1/Th2 chemokines by lung fibroblasts was examined in ELISA and quantitative reverse transcriptase polymerase chain reactions. Th1/Th2 chemokine levels in BAL fluid of idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) were examined to evaluate the clinical relevance of Th1/Th2 chemokines. RESULTS: The lung fibroblasts were polarized to produce Th1-type chemokines by the pro-inflammatory cytokine, tumor necrosis factor (TNF)-alpha and the anti-fibrotic cytokine, interferon (IFN)-gamma. However, the induction patterns of chemokines by these two cytokines were different, i.e., involving predominant induction of IP-10 and I-TAC by TNF-alpha and induction of Mig by IFN-gamma. Although Mig, IP-10, and I-TAC were produced within the BAL fluid of patients, TARC and MDC were at significantly low levels. CONCLUSIONS: Our results suggest that lung fibroblasts tend to induce a Th1-type immune response under normal conditions, and that a Th2-type immune response does not play a significant role in smoldering inflammation around the established lesions in IPF and NSIP.

  93. Pharmacogenetic approach for cancer treatment-tailored medicine in practice Reviewed

    Hasegawa, Y., Ando, Y., Ando, M., Hashimoto, N., Imaizumi, K., Shimokata, K.

    Annals of the New York Academy of Sciences   Vol. 1086   page: 223-232   2007

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  94. Macrophage-derived chemokine in malignant and tuberculous pleural effusions Reviewed

    OKAMOTO M, IMAIZUMI K, HASEGAWA Y, HASHIMOTO N, SUMIDA A, SHIBAZAKI M, TAKAGI K, SHIMOKATA K, KAWABE T

    Respirology   Vol. 12   page: 581-584   2007

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  95. Successful re-treatment with gefitinib for carcinomatous meningitis as disease recurrence of non-small-cell lung cancer. Reviewed

    Hashimoto N, Imaizumi K, Honda T, Kawabe T, Nagasaka T, Shimokata K, Hasegawa Y

    Lung Cancer   Vol. 53   page: 387-390   2006

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  96. Expression of macrophage-derived chemokine (MDC)/CCL22 in human lung cancer. Reviewed

    Nakanishi T, Imaizumi K, Hasegawa Y, Kawabe T, Hashimoto N, Okamoto M, Shimokata K

    Cancer Immunol Immunother   Vol. 55   page: 1320-1329   2006

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  97. Pulmonary infectious complications associated with anti-TNFalpha therapy (infliximab) for rheumatoid arthritis. Reviewed

    Imaizumi K, Sugishita M, Usui M, Kawabe T, Hashimoto N, Hasegawa Y

    Intern Med   Vol. 45   page: 685-688   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  98. T-helper type 1/T-helper type 2 balance in malignant pleural effusions compared to tuberculous pleural effusions. Reviewed

    Okamoto M, Hasegawa Y, Hara T, Hashimoto N, Imaizumi K, Shimokata K, Kawabe T

    Chest   Vol. 128   page: 4030-4035   2005

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  99. Evaluation of interferon-gamma, interferon-gamma-inducing cytokines, and interferon- gamma- inducible chemokines in tuberculous pleural effusions. Reviewed

    Okamoto M, Kawabe T, Iwasaki Y, Hara T, Hashimoto N, Imaizumi K, Hasegawa Y, Shimokata K

    J Lab Clin Med   Vol. 145   page: 88-93   2005

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    Language:English   Publishing type:Research paper (scientific journal)  

  100. Bone marrow-derived progenitor cells in pulmonary fibrosis. Reviewed

    Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH

    J Clin Invest   Vol. 113   page: 243-252   2004

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  101. CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury. Reviewed

    Hashimoto N, Kawabe T, Imaizumi K, Hara T, Okamoto M, Kojima K, Shimokata K, Hasegawa Y

    Am J Respir Cell Mol Biol   Vol. 30   page: 808-815   2004

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  102. CCAAT/Enhancer-Binding Protein b Isoforms and the Regulation of a-Smooth Muscle Actin Gene Expression by IL-1b. Reviewed

    Hu B, Wu Z, Jin H, Hashimoto N, Liu T, Phan SH

    J Immunol   Vol. 173   page: 4661-4668   2004

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    Language:English   Publishing type:Research paper (scientific journal)  

  103. Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6. Reviewed

    Liu T, Jin H, Ullenbruch M, Hu B, Hashimoto N, Moore B, McKenzie S, Lukacs NW, Phan SH

    J Immunol   Vol. 173   page: 3425-3431   2004

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    Language:English   Publishing type:Research paper (scientific journal)  

  104. Critical involvement of CD40 in protection against herpes simplex virus infection in murine model of genital herpes. Reviewed

    Inagaki-Ohara K, Kawabe T, Hasegawa Y, Hashimoto N, and Nishiyama

    Archves of Virology   Vol. 147   page: 187-194   2002

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    Language:English   Publishing type:Research paper (scientific journal)  

  105. Perfusion and ventilation isotope lung scans in constructive bronchiolitis: A series of three cases. Reviewed

    Hasegawa Y, Imaizumi K, Sekido Y, Iinuma Y, Kawabe T, Hashimoto N, Shimokata K

    Respiration   Vol. 69   page: 550-555   2002

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    Language:English   Publishing type:Research paper (scientific journal)  

  106. Effect of erythromycin on matrix metalloproteinase-9 and cell migration. Reviewed

    metalloproteinase-9 and cell migration.Hashimoto N, Kawabe T, Imaizumi K, Hara T, Okamoto M, Kojima K, Shimokata K, Hasegawa Y

    J Lab Clin Med   Vol. 137   page: 176-183   2001

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  107. Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-g gene into lung cancer. Reviewed

    Noguchi M, Imaizumi K, Kawabe T, Wakayama H, Horio Y, Sekido Y, Hara T, Hashimoto N, Takahashi M, Shimokata K, and Hasegawa Y

    Cancer Gene Therapy   Vol. 8   page: 421-429   2001

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    Language:English   Publishing type:Research paper (scientific journal)  

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Books 7

  1. Pulmonary Malignancies (1): Lung Cancer-What Are the Roles of Genetic Factors in Lung Cancer Pathogenesis?

    Hashimoto N., Sato M., Hasegawa Y( Role: Joint author)

    Springer, Singapore  2018  ( ISBN:978-981-10-8143-9

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    Language:English Book type:Scholarly book

  2. 血液疾患および臓器移植後の肺病変、間質性肺炎を究める

    橋本 直純、長谷川 好規( Role: Joint author)

    メジカルビュー  2012 

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    Language:Japanese

  3. 【上肺疾患、感染症、免疫】

    橋本 直純( Role: Joint author)

    【コリンズスターン 胸部画像診断エッセンシャル】、第1版  2011  ( ISBN:9784890134083

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    Language:Japanese Book type:Scholarly book

  4. Endothelial-Mesenchymal Transitionと肺線維症

    橋本 直純( Role: Sole author)

    先端医学社  2011 

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    Language:Japanese

  5. 治療学 間質性肺炎と肺線維症 パラダイムシフト後の臨床『間質性肺炎と発がん』

    橋本 直純、長谷川 好規( Role: Joint author)

    ライフサイエンス出版  2010.5 

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    Language:Japanese

    特発性肺線維症が肺癌の発生母地になりうることを示した基礎的研究について検証して、特発性肺線維症と発がんについて考察されたreviewである。

  6. 呼吸器症候群(第2版) III-その他の呼吸器疾患を含めて-『 白血病の肺病変 』

    橋本 直純( Role: Joint author)

    日本臨床社  2009.9 

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    Language:Japanese

  7. THE LUNG perspectives・肺線維症と骨髄由来前駆細胞

    橋本 直純( Role: Sole author)

    メディカルレビュー社  2007.11 

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    Language:Japanese

    肺線維症における骨髄由来前駆細胞の関与に関する知見を明快に解説

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Presentations 11

  1. 慢性炎症・線維症がもたらす組織微小環境と肺癌耐性獲得

    橋本 直純

    第59回日本呼吸器学会学術講演会 教育講演  2019.4.14 

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    Event date: 2019.4

    Presentation type:Oral presentation (invited, special)  

    Venue:東京  

  2. The pathogenesis and unresolved issues of idiopathic pulmonary fibrosis Invited International conference

    Hashimoto N

    23rd Congress of the Asian Pacific Society of Respirology 

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    Event date: 2018.11 - 2018.12

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Taipei, Taiwan   Country:Taiwan, Province of China  

  3. 間質性肺炎の診断と治療の新展開 Invited

    橋本 直純

    第80 回日本内科学会東海⽀部主催⽣涯教育講演会 教育講演  2021.6.27  日本呼吸器学会東海支部

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    Event date: 2021.6

    Presentation type:Oral presentation (invited, special)  

    Venue:名古屋  

  4. Primary ciliary dyskinesia in Japan International conference

    Hashimoto N, Hasegawa Y, Keicho N, Takeuchi K, Takase M, Hijikata M, Homma S, Inase N

    23rd Congress of the Asian Pacific Society of Respirology 

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    Event date: 2018.11 - 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Taipei, Taiwan   Country:Taiwan, Province of China  

  5. 喫煙による慢性閉塞性肺疾患(COPD)・気腫がもたらす健康増進への影響について Invited

    橋本 直純

    第13回日本禁煙科学会学術総会in愛知 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  6. COPD合併例の周術期管理 Invited

    橋本 直純

    第58回日本呼吸器学会学術講演会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  7. 肺癌検診とCOPD Invited

    橋本 直純

    第46回日本総合検診医学会 

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    Event date: 2018.1

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  8. 骨髄移植後肺合併症 骨髄移植後びまん性細気管支炎(BO) Invited

    橋本 直純

    第57回日本呼吸器学会学術講演会 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  9. Endothelial-MTと肺線維症

    橋本 直純

    第48回日本呼吸器学会学術講演会シンポジウム「社会のニーズに応える呼吸器学の展開-肺損傷から線維化へのパラダイムとその制御-」 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  10. 肺線維症と骨髄由来前駆細胞

    橋本 直純

    第46回日本呼吸器学会学術講演会 シンポジウム「Stem cellを用いた呼吸器細胞への分化と機能」 

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    Event date: 2006.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  11. 線維化機序の解明における新展開

    橋本 直純

    第87回日本呼吸器学会東海地方学会シンポジウム「」特発性間質性肺炎の理解をめぐって 

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    Event date: 2005.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 11

  1. 間質性肺炎に対する多施設共同前向き観察研究

    2020.4

    企業からの受託研究 

  2. シグナルペプチド:細胞外微粒 子機能の新規マーカー

    2017.11

    CREST 

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    Grant type:Competitive

  3. 肺上皮細胞特異的細胞間接着分子欠損マウスにおける発癌機序の解明

    2015.4 - 2016.3

    学内共同研究 

  4. 慢性閉塞性肺疾患(COPD)の早期発見と禁煙指導の取り組み~COPDの病態解明を目指して~

    2011.4 - 2012.3

  5. 慢性閉塞性肺疾患(COPD)の早期発見と禁煙指導の取り組み~COPDの病態解明を目指して~

    2011.4 - 2012.3

    学内共同研究 

  6. 14印環マクロライドによる微小血管内皮細胞上のCXCR4発現誘導

    2008.4 - 2008.5

    学内共同研究 

  7. 幹細胞誘導遺伝子導入線維芽細胞を用いた肺再生治療

    2007.4 - 2008.3

    学内共同研究 

  8. 線維芽細胞の起源再考からの肺線維症の病態解明と治療法の開発

    2005.4 - 2006.3

    学内共同研究 

  9. 特発性間質性肺炎病態形成における骨髄由来細胞の関与と治療法の開発

    2004.7 - 2005.3

    学内共同研究 

  10. 固形癌転移機序、特に細胞の形質転換に伴う細胞可動性・遊走性に関する検討

    2004.7 - 2005.3

    学内共同研究 

  11. ヒトゲノム情報に基づいた肺線維化に関わる標的分子の同定と機能解析

    2002.4 - 2003.3

    学内共同研究 

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KAKENHI (Grants-in-Aid for Scientific Research) 11

  1. Immune-pathological diagnostic artificial intelligence development research for pulmonary fibrosis using fibrotic foci-specific enhanced micro-CT

    2020.4 - 2022.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for challenging Exploratory Research

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    Authorship:Principal investigator 

  2. 生体応答を模倣した細胞内導入デリバリーシステムを用いた肺線維症の新規治療法の開発

    2015.4 - 2017.3

    科学研究費補助金 

    橋本 直純

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    Authorship:Principal investigator 

  3. 肺構成細胞間葉系形質転換に対するPTENC末端リン酸化を標的とした新規治療戦略

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  4. 血管内皮間葉系細胞転換機序を標的とした肺線維症および肺高血圧症の治療戦略の構築

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(C)(一般)・21590987

    橋本 直純

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    Authorship:Principal investigator 

  5. 幹細胞誘導遺伝子導入による線維芽細胞由来幹細胞を用いた肺再生医療の構築

    2007.4

    科学研究費補助金  日本学術振興会科学研究費補助金 基盤研究(C); 課題番号19590890

    橋本 直純

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    Authorship:Principal investigator 

  6. 線維芽細胞の起源再考からの肺線維症の病態解明

    2005.4 - 2007.3

    科学研究費補助金  文部科学省科学研究補助金若手研究 (B);課題番号17790530

    橋本 直純

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    Authorship:Principal investigator 

  7. 慢性閉塞性肺疾患に対する肺再生治療の基盤構築

    2011.4 - 2013.3

    科学研究費補助金 

    長谷川 好規

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    Authorship:Coinvestigator(s) 

  8. リンパ管新生関連遺伝子発現に基づく肺癌リンパ節転移の機序解析と診断、治療法の開発

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(C)

    今泉 和良

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    Authorship:Coinvestigator(s) 

  9. マイクロフルイディクスによる循環血液癌細胞検出法の開発と癌転移機構の解析

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(B)(一般)

    長谷川 好規

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    Authorship:Coinvestigator(s) 

  10. 上皮間葉系細胞転換(EMT)分子(NOTCH)を標的にした固形癌制御の研究

    2007.4 - 2008.4

    科学研究費補助金  日本学術振興会科学研究費補助金 萌芽研究; 課題番号19659211

    長谷川 好規

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    Authorship:Coinvestigator(s) 

  11. Immune-pathological diagnostic artificial intelligence development research for pulmonary fibrosis using fibrotic foci-specific enhanced micro-CT

    Grant number:20K21599  2020.7 - 2022.3

    Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Principal investigator 

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

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Teaching Experience (On-campus) 30

  1. 医学入門 Human Biology : Respuratory System

    2018

  2. 生涯健康と医学

    2018

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    全学2年生後期授業の「生涯健康と医学」の中で、「喫煙と呼吸器疾患」の講義を実施

  3. 呼吸器系統学的講義「拘束性肺疾患・肉芽腫性肺疾患」

    2018

  4. 基本的臨床技能実習

    2018

  5. 医学入門 Human Biology : Respuratory System

    2017

  6. 呼吸器系統学的講義「拘束性肺疾患・肉芽腫性肺疾患」

    2017

  7. 基本的臨床技能実習

    2017

  8. 医学入門 Human Biology : Respuratory System

    2016

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    1年生を対象とした医学入門講義

  9. 呼吸器系統学的講義「拘束性肺疾患・肉芽腫性肺疾患」

    2016

  10. 基本的臨床技能実習

    2016

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    胸部X-P読影

  11. 医学入門 Human Biology : Respuratory System

    2015

  12. 呼吸器系統学的講義「拘束性肺疾患・肉芽腫性肺疾患」

    2015

  13. 基本的臨床技能実習

    2015

  14. 医学入門 Human Biology : Respuratory System

    2014

  15. 呼吸器系統学的講義「拘束性肺疾患・肉芽腫性肺疾患」

    2014

  16. 基本的臨床技能実習

    2014

  17. 医学入門 Human Biology : Respuratory System

    2013

  18. 呼吸器系統学的講義「全身性疾患の肺病変」

    2013

  19. 基本的臨床技能実習

    2013

  20. 医学入門 Human Biology : Respuratory System

    2012

  21. 呼吸器系統学的講義「全身性疾患の肺病変」

    2012

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    呼吸器系統学的講義「全身性疾患の肺病変」

  22. 基本的臨床技能実習

    2012

  23. 医学入門 Human Biology : Respuratory System

    2011

  24. 呼吸器系統学的講義「全身性疾患の肺病変」

    2011

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    呼吸器系統学的講義

  25. 基本的臨床技能実習

    2011

  26. 呼吸器系統学的講義「全身性疾患の肺病変」

    2010

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    呼吸器内科系統的講義

  27. 基本的臨床技能実習

    2010

  28. 呼吸器系統学的講義「全身性疾患の肺病変」

    2009

  29. 基本的臨床技能実習

    2009

  30. 基本的臨床技能実習

    2008

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Social Contribution 5

  1. 講演「肺の生活習慣病!COPDってなに?」

    Role(s):Lecturer

    愛知県健康福祉部保健医療局健康対策課  平成30年度COPD講演会 みて・きいて・体験しよう!肺のお話  2019.1

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    Audience: General, Governmental agency

    Type:Lecture

    講演

  2. 平成26年度 難病講演会 サルコイドーシス講演会

    2014.10

  3. 平成25年度 呼吸器系難病患者・家族の集い

    2013.12

  4. 平成25年度 結核対策講演会

    2013.11

  5. 第42回大気汚染公害認定研究会 研究会Ⅲ

    2013.2